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Are vitamins helpful?
According to a report on Adelaide Channel 9, vitamins do nothing, are a waste of money, and some herbal supplements cause liver damage. As usual, Channel 9 neglected to get the real story, did not read the thousands of studies proving the benefits of vitamins, or allow the alternative health industry to respond. Just one example: Vitamin D3 at a healthy dose of 5000 IU (5 times the normal dose) can reduce risk of cancer between 50% and 90% and high-dose vitamin C can also help significantly. If a drug company developed a drug to perform as well, they would charge a fortune and want a Nobel Prize for inventing it!
LeanMachine has not had a cold or flu or even a headache since adopting a Paleo-style diet and a host of vitamin and mineral supplements in the year 2010 at age 63. Now at age 70, LeanMachine is healthier, stronger with more energy than at any time in his life, all allergies gone and never gets sick!
Back to Channel 9 and liver damage - they neglected to mention that most people on the liver transplant waiting list are there because of Paracetamol overdose, and many cancer patients suffer because of Paracetamol, causing destruction of natural L-Glutathione (the "Master Antioxidant"), our main defense mechanism against cancer and most other diseases. Obviously another fake story by Big Pharma to retain their profits and keep people sick, and shame on Channel 9 to be a part of this!
Almost every one of our 60 to 100 trillion body cells has Vitamin D3 receptors, and D3 is essential for mineral absorption, bone building, and disease prevention.
One year supply at 5x normal strength, only AU$17. Vitamin D3 article.

Alzheimer's Cure

Doctors say there is no cure for Alzheimer's Disease, in spite of over 80 billion dollars in research over the last few decades.
This is partly true, as there is no drug, no "magic bullet" to slow or stop this dreadful condition.
Hundreds of studies with new drugs have shown most of the time that those on a placebo did BETTER than those on the drug!
In rare cases, those on the drug did very slightly better, but any improvement was not enough to justify bringing the drug to market.
However, we CAN identify risk factors, and we CAN in most cases prevent the onset of Alzheimer's, and we CAN in most cases reverse the disease, or at least ease the symptoms to give the patient and the carers a better quality of life.
If the intervention is soon enough, it CAN be CURED in some, but not all cases.
There is no miracle one-shot treatment, but a combination of many factors. The time to start treatment is not when we are 60 and forget where the keys are, but from birth!
The lifetime changes we need to prevent Alzheimer's will also prevent heart disease, diabetes, cancer and many other diseases, and give our lives vitality.

How many people are at risk?

IN the USA, over 5 million Americans have Alzheimer’s disease, and around 14% of the population will eventually get Alzheimer's, or around 45 million people.
Results in Australia are similar. Over 10% of the population over 65 have Alzheimer's, and 30% of those over 85 have Alzheimer's.
Most are too young to know that it's coming, although many are now showing signs as young as 30.
In the USA, it is now the third leading cause of death, but these figures could be understated. People do not actually die from Alzheimer's - they die because the parts of the brain that control bodily functions shut down, so they die when their organs shut down. The patient may die fron pneumonia because the lungs now cannot function or some other organ fails to work and the Doctor or Coroner has to determine which organ failed.

This is a problem in every country, but some countries have very much reduced rates of Alzheimer's.

Diagnosis

Originally, there was no firm diagnosis without examining the brains of patients after death. Researchers found that most patients had Amyloid Plaques in the brain, and also high levels of aluminium.
PET scans (Positron Emission Tomography) are used with a radioactive tracer (which binds to amyloid plaques) to determine the amount and location of amyloid plaques in the brain.
However, this diagnosis is still not conclusive, as many people have amyloid plaques, but no sign of any dementia even into old age, although these people have a higher risk. Often symptoms do not appear for decades after the start of amyloid plaque deposits.
Standard blood tests for glucose levet, triglycerides, kidney and liver function can help determine the risk.
So the PET scan is used with other tests for cognitive performance to arrive at a diagnosis.

Who is at risk?

Genetics plays an important part, and so does diet, exercise, lifestyle and supplements.
Here are some risk factors, in no particular order:
Overcoming risk factors:

Genetics

There is a strong genetic predisposition to Alzheimer’s, but also there is a strong contribution of environment, diet and lifestyle.
Rates of Alzheimer’s disease have increased much faster than any genetic changes could have occurred. This means that much is under our control, because even with a genetic predisposition, we can reduce risk with epigenetic (non-genetic influences on gene expression) changes.
Example: The most important genetic risk factor is the ApoE epsilon 4 allele (ApoE4), and 14% to 18% of the population has this gene.
Everyone carries two copies of the APOE gene, which makes the protein ApoE (apolipoprotein E).
There are three different types (alleles) of the APOE gene: E2, E3 and E4, and because we all have two copies of the gene, the combination determines our APOE "genotype" which can be any combination of the 2 copies: E2/E2, E2/E3, E2/E4, E3/E3, E3/E4, or E4/E4.
The majority of people have two E3 alleles (E3/E3) so this is defined as the "average risk".
The E2 allele is the least common form, and if we have two E2 alleles (E2/E2) or one E2 and one E3 (E2/E3) we have about 40% REDUCED risk of Alzheimer’s.
The E4 allele, present in 14% to 20% of the population, increases the risk for Alzheimer’s, especially late-onset Alzheimer’s, but this does NOT mean that we will get Alzheimer’s disease if we have one or two copies of E4, as about one third of Alzheimer’s patients do not have even a single E4.
All it means is that our risk is increased, also increased is the risk of potential Alzheimer's at a younger age.
To quantify the risk:
If we have no copies of E4, we still have around 9% risk of Alzheimer’s.
If we have a single copy of E4, our risk increases to around 30%.
If we have two copies of E4, risk is between 50% to 90% but in all cases, we CAN REDUCE the risk.
Many people are horrified to learn that they have up to a 90% risk of Alzheimer's, but they need not be. With some dietary, lifestyle and supplement changes, those at greatest risk can easily fall into the 10% who do NOT get Alzheimer's.

SAD (Standard American Diet)

Genetic statistics above apply only to average people, typically Caucasians living in the Western World and consuming a typical Western diet of processed food, sugar, MSG, hydrogenated oils, chemicals, heavy metals, pesticides, insecticides and other toxic substances.
These statistics do NOT apply to those with a healthy diet of natural, organic food living in a low-toxin environment. In fact, many people already down the cognitive decline have recovered on a healthy diet and sustained the improvement for several years, according to Dr Dale Bredesen who has been running a program for years now.
Dr Bredesen does not know how many more years it will be, but does know that patients on the program have removed the biochemical drivers which can be measured in blood tests, so so is very optimistic about their future health for many years to come.

Should we get genetic testing?

This is up to the individual. Some people would prefer not to know. Others want to know. My father died from Alzheimer's at about the age I am now as I write this article (nearly 70), and so did my Grandmother on my Mother's side, so I assume I may well have inherited a high genetic risk. For me, testing is irrelevant, because I changed to a Paleo-style diet at age 63, which turned my life around. Frome obese to lean, from grey hair to brown, from allergies to everything to allergies to nothing, from high blood pressure and triglycerides to normal, from poor physical strength to strong, fit and full of energy, from frequent headaches to none, from always getting sick to never getting sick.
If I had the genetic test and it was the worst result, I would only continue to do what I am doing now, using dietary and lifestyle modifications.
Have I halted Alzheimers? I think so. Come back here in thirty years as I approach 100 and I will let you know how I have done.

Amyloid Plaques

Amyloid is a protein, normally found throughout the body. In Alzheimer's, this protein divides improperly, creating beta amyloid which is toxic to brain neurons. Amyloid is actually antimicrobial and has benefits for the body, but some people, especially those with the E4/E4 anneles cannot naturally break down these plaques, but there are dietary methods which can.
Not all Alzheimer's patients have beta Amyloid plaques. About 10% of patients have neurofibrillary tangles which case similar symptoms, but are also inclined to have aggressive behaviour.

Three Kinds of Alzheimer's

Humans liberate amyloid as a protective response in the body to three different fundamental metabolic and toxic perturbations:
Some patients have "Alzheimer's type 1.5" where a combination of symptoms of both type 1 and 2 Alzheiner's occurs.
Glycotoxicity (too much sugar in the brain) causes an insulin resistant brain. Combine this with AGEs (Advanced Glycation End products), and we have both inflammation from AGEs, plus atrophic withdrawal response because we are now resistant to insulin. So we have a double condition of type 1 and type 2.

Type 3 patients often have MARCoNS (Multiple Antibiotic-Resistant Coagulase-Negative Staph), a colonisation of antibiotic-resistant staphylococcus in the nasal cavity.
Also high blood levels of TGF-beta-1 (Transforming Growth Factor beta-1), high C4A (a protein that in humans is encoded by the C4A gene), and low MSH (Melanocyte-Stimulating Hormone) is very common, typically with HLA-DR/DQ haplotypes shown by Dr Ritchie Shoemaker to be associated with CIRS.

Alzheimer's from nose infections?

We have known for years that our healthy gut bacteria is essential to prevent almost every disease, and now research is looking at the rhinosinal microbiome, the healthy bacteria in our nose.
This is now becoming known as Inhalational Alzheimer's.
The nose is the most direct route to the brain, and bad bacteria in the mucous lining of the airways can damage the brain. Pathologists now believe there are unknown pathogens in the rhinencephalon, the "nose-smell" (olfacation) system. Many Alzheimer's patients start losing their sense of smell as one of the early signs of the disease, and this is probably why. I am confident that my nasal bacteria is back to normal after having very bad allergies and taking antihistamines from when I was about 16 to when I was 63. Allergies stopped when the bad diet stopped.

Dr. Susan Lynch at UCSF has found that the nose problem is not so much an unknown pathogen, but a lack of microbial diversity. Beneficial microorganisms in the nose protect against many pathogens, and one of the best seems to be Lactobacillus sakei, used to make sake and kimchi. This could explain why Japanese people have comparatively low rates of Alzheimer's, although rates are rising in Japan because of the Western influence, with meat and dairy replacing rice as a staple food.
When Japanese people migrate to Western countries and adopt a Western diet, they have the same risk as anyone else. So for the Japanese, it is not a genetic problem, but a diet problem, and this applies to everyone.

AGEs - Advanced Glycation End products

AGEs are formed when food cooked at high temperatures (over 120 degrees C) combines with sugar. AGEs are very damaging to the body, accelerating the ageing process and chronic disease. AGEs worsen diabetes, kidney disease, Alzheimer's, inflammation, atherosclerosis (stiffening of the arteries), cardiovascular disease and stroke.
AGEs cause glycation of LDL cholesterol, promoting oxidation, and oxidized LDL is a major factor in atherosclerosis. AGEs form photosensitizers in the eye lens, leading to cataract development.

To reduce AGEs, never cook at high temperatures (steaming is best, always at 100 degrees C), eat plenty of raw food (salads, and small amounts of fruit), and eliminate all sugar and processed foods.

Conventional Drugs

Drug companies have been trying for years to get rid of Amyloid plaques, thinking they are the cause of Alzheimer's.
However, the body needs amyloid to protect the brain, so we need to look at what is causing the plaques instead of trying to get rid of them.
Latest research shows that Amyloid plaques are antimicrobial, so can be both damaging and protecting!

The Cholesterol Fraud

Previous research indicated that high cholesterol was a risk factor for Alzheimer's.
Again, this was wrong. Doctors started prescribing statin drugs for those people with high cholesterol, or those with signs of dementia with normal cholesterol. What happened was that they got Alzheimer's worse and got it faster than patients who did not take statins. Researchers only looked at total cholesterol which is a complete waste of time.
Cholesterol is NOT the enemy.
We NEED cholesterol, especially HDL (High Density Lipoprotein) cholesterol which reduces inflammation, and helps clean up the body (like a garbage collector). If we lose the ability to clean up our waste, we die within 24 hours. I tried telling this to my teenage daughter many years ago, but it made no impact on her bedroom...
We also need LDL (Low Density Lipoprotein), still incorrectly called "bad" cholesterol.
LDL has antimicrobial effects, so the idea that we should drive it down to zero is ludicrous. LDL is essential to transport nutrients around the body (and into the brain).
LDL was essential for our evolutionary ancestors millions of years ago, and we still need it.
The brain is mostly fat, and 40% of the brain is CHOLESTEROL.
Many things that were protective in our native environment are problems in our modern environment, but if we go back to our ancestral diet, problems are resolved.
Studies show time after time that people with low cholesterol die young, while people with normal to high cholesterol live longest.
These studies are ignored by the big drug comanies. Because statin sales make them billions of dollars, of course they continue the Big Cholesterol Lie, one of the biggest frauds in medical history.
The dangerous cholesterol is VLDL (Very Low Density Lipoprotein) which cannot easily be tested. Because triglycerides contain some VLDL, labs estimate VLDL value by simply taking a percentage of triglycerides. High triglycerides are much more of a danger signal than high cholesterol, and are almost always related to obesity, poor diet of processed foods, especially dangerous fats.
Alzheimer's Type 2 in particular can be CAUSED by low cholesterol, resulting in atrophy (brain shrinkage), reduced hormone production, poor health and eventually Alzheimer's.
All because we are taking statins.
We prevent our cells from doing wehat they are supposed to do, so we end up with a shrunken brain without the lipid (fat) content we need.
A fat-free diet means atrophy of the brain.

Alzheimer's - "Diabetes Type 3"

Some researchers are now labelling Alzheimer's as "Diabetes Type 3" because sugar causes Alzheimer's.
Sugar also causes diabetes, cardiovascular disease, obesity and many more diseases, mainly due to processed foods.
As with diabetes, where sugar causes insulin resistance, we have insulin resistance in the brain, causing degeneration.
When the brain becomes insulin resistant, it means that glucose cannot enter the brain cells, so those cells die.
However, all is not lost. If we switch to a Ketonegic diet, we can feed our brain with fat instead of sugar. More on this diet below.

Diagnosing the type of Alzheimer's

Unlike cancer, where we can biopsy a tumour, we must look at historical, biochemical, genetic, imaging, and function information to determine the type of Alzheimer's.
Of course this rarely happens except in reaseach applications. The doctor simply says the patient has Alzheimer's and may give a drug which in the long term will not make much difference.
This is a shame, because about half of all cases can be halted, and in some cases substantially improved, by reverting to the correct diet.
Even better would be to eat a correct diet from birth, reducing the risk of Alzheimer's to near zero, as well as preventing cancer, heart disease, diabetes and other modern diseases.

Exercise

Physical exercise is extremely important to keep the brain healthy. Researchers are not sure why, but LeanMachine says it is obvious: Exercise burns off the high glucose levels that cause "Diabetes of the Brain" and exercise boosts oxygen levels and circulation in the brain.
Any type of exercise is beneficial, such as:
Exercises have the added benefit of socialisation in a group, such as:

Exercising the Brain

The body has a disturbing property: Anything not used for a while gets broken down to be used somewhere else.
If we do not use a muscle for a week, the body starts breaking it down.
But if we exercise regularly, we stop muscles wasting, and we actually build up our muscles.
If we do not use parts of the brain, the body starts breaking it down.
But if we exercise our brain, we can hang on to the parts we use, and develop new pathways to replace parts we have lost. Exercises such as:

Meditation

Meditation is not normally seen as exercise for the brain, but sitting in a quiet, dark room away from all daily distractions not only promotes a calming effect, but increases various brain-saving hormones.
Meditation, like dreaming, helps the brain sort out the junk memories and recent problems by concentrating on things that have made us feel good in the past. We may have pleasant memories like sitting on a sandy beach listening to the waves rolling in on a beatiful sunny day. By concentrating on peaceful and pleasant memories, we forget problems with out hectic daily life.

Supplements

The modern diet is lacking in vitamins, minerals, amino acids and other nutrients, mainly because of:
The supplements everyone over 50 should take are:
- Organic Coconut Oil taken several times a day, a tablespoon at a time. LeanMachine considers this one of the best prevention and treatment methods available for Alzheimer's. This encourages the body to burn healthy fats instead of sugar, called the Ketogenic Diet which burns ketones, which is what our ancestors did in their low-carb diets. See the Ketogenic Diet below.
Coconut oil helps to break down the amyloid plaque buildup in the brain.
Coconut oil is also the absolute best for cooking, replacing any other fat, because coconut oil remains stable at high temperatures, and is full of MCT (Medium Chain Triglycerides) which go straight to the liver to be burned as fuel, and cannot be stored as fat in the body. Coconut oil also contains Lauric Acid, which keeps our skin wrinkle-free and healthy.

- Phosphatidylserene is a component of the cerebral cortex’s neuronal membrane, and can improve memory and mood, reduce stress, improve learning and more. It does this by controlling input and production of choline, acetylcholine, norepinephrine, dopamine and glucose.

- NAC (N-Acetyl Cysteine) which helps the body make L-Glutathione the "Master Antioxidant" which fights cancer Alzheimer's and many other conditions.

- Curcumin is the active ingredient in Turmeric which has ben used for thousands of years for dementia, cancer and many other conditions.

- Vitamin B-12 because as we age, our stomach acid levels drop, preventing the high-acid conditions required for B-12 absoption from food. Even more essential for vegans and vegetarians as B-12 only comes from animal products.

- B-group vitamins because these are vitally important for brain health.

- ALA (Alpha Lipoic Acid) as an antioxidant to help remove heavy metals from the brain, reduce inflammation, and improve the effectiveness of votamins C and E.

- Vitamin D3 because over half the ageing population are taking statin medication (which they should NOT) and statins halt production of 7-dehydrocholesterol, the first step in the manufacture of vitamin D3. Worse, many of these seniors are in Aged Care facilities and never see the light of day, so cannot make vitamin D3 from sunlight. If they are ever taken outside, it is only early morning or late afternoon when they cannot get vitamin D3 anyway.
More info in my Vitamin D3 article.

- Ginkgo Biloba is highly recommended to improve blood flow in the brain.

- TMG (Trimethylglycine) is an effective methyl donor for the facilitation of methylation processes. Supports a healthy homocysteine level, which in turn supports healthy cardiovascular function and helps prevent Alzheimer's.
Homocysteine, a damaging amino acid, with the aid of TMG, is turned into methionine, a safe and beneficial amino acid.
Methylation is essential for DNA repair and production of SAMe, which helps joints, lifts mood, fights depression and protects brain cells from amyloid plaques.

- SAMe (S-Adenosyl Methionine) can help protect the brain and also help treat depression, anger, anxiety which are common symptoms in some Alzheimer's patients.

- Vinpocetine has shown mixed results but mostly beneficial in limited human trials using 10mg 3 times daily.

- Huperzine A like Vinpocetine, helps protect the brain.

- Vitamin E is recommended to improve the healthy fats in the brain and increase antioxidants.

- Benfotiamine can help remove glucose and improve insulin resistance.

- Myelin Sheath Support contains 14 vitamins and minerals shown to help prevent Alzheimer's, as well as 27 beneficial nutritional products.

Many other supplements can help, including:
In addition, many supplements primarily used to treat diabetes will also help prevent Alzheimer's.

The Big Cholesterol Lie and the Big Fat Lie

The Big Cholesterol Lie

Around 60% of our brain is fat. Starve the brain of healthy fat, and we get Alzheimer's. Almost guaranteed.
25% of the cholesterol in the body is in the brain, mainly in the myelin sheath (oligodendroglia) that surrounds and protects the nerve cells. Myelin sheaths are 70% lipids (cholesterol) and 30% protein.
Reduce cholesterol and what happens? The protective myelin sheaths break down as they are starved of cholesterol, allowing the brain cells to be damaged. Damage them enough, and they die. Then we have dementia. Damage enough cells, and the brain can no longer support our basic functions, like breathing. Then we die.
This is why statin drugs are BAD. Sure, in some cases, they can slightly reduce risk of heart attacks, but they INCREASE death from all other causes, including Alzheimer's. The net result is that we will not live a day longer on statin medication. Statins will give us lousy final years with muscle breakdown, osteoporosis, more sickness and dementia.
We need plenty of healthy fats like coconut oil, walnuts, avocados, fish, eggs, butter from grass-fed cows, olive oil (unheated only), etc.
We must NOT consume bad fats: Canola oil, margarine, anything hydrogenated, anything overheated.

The Big Fat Lie

We have been told for decades that fat is bad for us. First, forget about "low fat" or "fat free" diets.
Another big fat lie, coming from a scientist who plucked figures out of a study to suit an argument he was proposing. When the data was analysed completely, many decades later, it showed the complete opposite.
The largest study in the world was the Framingham study which showed that those who ate the most fat lived longer than those who ate the least.
Fat is not unhealthy in general, in fact it is essential for health.
The UNHEALTHY fats are man-made artificial fats (margarine, Canola oil) and other processed fats that are hydrogenated to improve shelf life and heated to extremes during manufacture, often going rancid in the process, causing oxidised VLDL (Very Low Density Lipoprotein), the REAL dangerous "food".
What is REALLY bad is carbohydrates, and when manufacturers remove fats from food, they replace them with carbohydrates, causing most "modern" diseases including Alzheimer's and Diabetes.

The Ketogenic Diet

For the first two million years of human life on Earth, carbohydrate consumption was very low. Carbohydrates were uncommon, with the majority of food being nuts, seeds, eggs, fish, fruit and vegetables. Meat was eaten very rarely when an animal was killed. These people did not burn carbohydrates for energy, they burned FAT. In particular, ketones, the basis of the ketogenic diet.

A ketogenic diet means maintaining a fasting state of ketosis. Ketones are produced when the body is in a state of ketosis.
Ketones fuel cells using a different pathway from glucose. Glucose has to have insulin to allow glucose into cells, but as we all should know, our trypical modern diet is loaded with carbohydrates, forcing the pancreas into overdrive making enough insulin. Eventually our cells become insulin resistant, so the pancreas produces even more insulin to force glucose into the cells, creating even more insulin resistance. We are now a full-blown diabetic, and when the pancreas starts shutting down, we need insulin injections for the rest of our life.
However, when we feed the cells with ketones, they simply enter the cell naturally, and do NOT require insulin or anything else to do so.
This is critically important for five of our modern diseases: Obesity, Cancer, Diabetes, Cardiovascular and Alzheimer's, all caused or aggravated by high blood glucose and inflammation.

Ketones are also signaling molecules as well.

Benefits of the ketogenic diet include:

The Anti-Alzheimer's diet

Spices

Add these spices to every meal possible. Of course they will spice up any meal, but also help clear the brain of problems and reduce risk of cardiovascular disease, cancer, diabetes and many more modern illnesses.

This section is still under construction and will be updated soon.
Please come back soon (if you remember!)


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Disclaimer

LeanMachine is not a doctor, and everyone should consult with their own health professional before taking any product to ensure there is no conflict with existing prescription medication.
LeanMachine has been studying nutrition and health since 2011 and has completed many relevant studies including:
Open2Study, Australia - Food, Nutrition and Your Health
RMIT University, Australia - Foundations of Psychology
Swinburne University of Technology, Australia - Chemistry - Building Blocks of the World
University of Washington, USA - Energy, Diet and Weight
Johns Hopkins Bloomberg School of Public Health, USA - Health Issues for Aging Populations
Johns Hopkins Bloomberg School of Public Health, USA - International Nutrition
Johns Hopkins Bloomberg School of Public Health, USA - Methods in Biostatistics I
Johns Hopkins Bloomberg School of Public Health, USA - Methods in Biostatistics II
Johns Hopkins Bloomberg School of Public Health, USA - Principles of Human Nutrition
TUFTS University, USA - Nutrition and Medicine
TUFTS University, USA - Lipids/Cardiovascular Disease I and Lipids/Cardiovascular Disease II
Technical Learning College, USA - Western Herbology, Identification, Formulas
Bath University, England - Inside Cancer
WebMD - The Link Between Stroke and Atrial Fibrillation
LeanMachine has now read thousands of studies, journals and reports related to health and nutrition and this research is ongoing.



Updated 22nd December 2016, Copyright © 1999-2017 Brenton Wight and BJ & HJ Wight trading as Lean Machine abn 55293601285