LeanMachine Notes on Nattokinase
Nattokinase is an enzyme (most names ending with "ase" refer to an enzyme), and is usually made by isolating from Natto, boiled soybeans fermented with bacteria Bacillus subtilis, a vegetable cheese popular in the Japan.
It has been used in Japan for over 1000 years for its popular taste and as a medicinal folk remedy.
Discovered by research scientist Dr. Hiroyuki Sumi while looking for a natural remedy for dissolving blood clots related to heart attack and stroke.
Nattokinase was found to have blood clot dissolving abilities, and also helps prevent the aggregation of red blood cells, improving blood flow.
Another enzyme becoming more popular is Serrapeptase.
Serrapeptase is found in the silk worm, but that is another story for later.
LeanMachine advises that both Nattokinase and Serrapeptase should be used under the advice of your medical specialist, as the combination of blood-thinning medications such as Warfarin, Coudamin or Aspirin, or even blood-thinning herbs such as Ginko Biloba and others may increase risk of internal bleeding in some patients, and dosage may require adjusting.
Mechanisms of ActionNattokinase inactivates plasminogen activator inhibitor type 1 and potentiates fibrinolytic activity. In plain English, this means it helps dissolve fibrin.
Fibrin is a blood-clotting protein that polymerises to form a mesh over a haemostatic clot or plug, in conjunction with platelets.
Fibrin is made from fibrinogen, which is a plasma glycoprotein synthesized by the liver.
Nattokinase helps prevent aggregation (clumping together) of red blood cells, reducing a problem known as "sticky blood".
Side effectsNo significant side effects have been reported when used without other blood-thinning medications, but there have not been enough human studies to prove benefits and risks.
Any person with a history or risk of haemorrhage or with any blood-clotting disorders should not take Nattokinase, but those with a history or risk of artery plaque build-up would be well advised to take Nattokinase, obviously under the doctor's supervision.
Those with blood-clotting disorders should be ensuring they get enough Vitamin K2 Mk 7 to help keep arteries clear by pushing calcium out of blood vessels and back into bones and teeth where it belongs.
Alzheimer's DiseaseNattokinase appears to pass through the blood-brain barrier, so may benefit those with early onset Alzheimer's or other brain problems.
A Taiwan study has found that Nattokinase may also help prevent Alzheimer's disease by dissolving amyloid fibrils, which form plaque in the brain, leading to brain cell damage, cognitive impairment and eventually Alzheimer's disease. Researchers also found that Nattokinase enzyme can dissolve fibrils that contribute to diabetes and CNS (central nervous system) degeneration.
Warfarin InteractionCan Nattokinase be taken with or as a substitute for Warfarin?
Many patients suffer from serious side-effects from Warfarin/Coudamin and would like to take less or none.
In a US study, about a third of all Emergency Room visits for those over 65 are for adverse events associated with warfarin (17.3%), insulin (13.0%) and digoxin (3.2%). These are three drugs commonly prescribed to seniors.
No studies have been undertaken to see how they interact, but LeanMachine suggests the following:
Monitoring of blood is required anyway if Warfarin/Coumadin is being taken, so the Warfarin dose could be reduced slightly while the Nattokinase is started in small doses.
If the INR and Prothrombin blood tests stay within the range determined by the doctor, the transition could continue, gradually swapping the doses every 2 weeks or so until only Nattokinase is required, but for some people this may not be achieved.
Again, this must be done under strict medical supervision.
Doctors must be advised if other natural blood thinners such as Gingko Biloba are also taken.
Effects of Nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity.
Clin Hemorheol Microcirc. 2006. Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
A fibrinolytic enzyme, termed nattokinase, can be extracted from natto; the enzyme is a subtilisin-like serine protease composed of 275 amino acid residues and has a molecular weight of 27.7 kDa.
In vitro and in vivo studies have consistently demonstrated the potent pro-fibrinolytic effect of the enzyme.
Blood samples were incubated with nattokinase for 30 minutes at 37 degrees C.
Our in vitro results showed a significant, dose-dependent decrease of RBC aggregation and low-shear viscosity, with these beneficial effects evident at concentrations similar to those achieved in previous in vivo animal trials.
Our preliminary data thus indicate positive in vitro haemorheological (flow properties) effect of nattokinase, and suggest its potential value as a therapeutic agent and the need for additional studies and clinical trials.
Blood PressureEffects of nattokinase on blood pressure: a randomized, controlled trial.
Hypertension Res. 2008: Yonsei University Research Institute of Science for Aging, Department of Food and Nutrition, Yonsei University, and Department of Family Medicine, Mizmedi Hospital, Seoul, Korea.
In a randomized, double-blind, placebo-controlled trial, 86 participants ranging from 20 to 80 years of age with an initial untreated systolic blood pressure of 130 to 159 mmHg received nattokinase (2,000 FU/capsule) or a placebo capsule for 8 weeks.
Seventy-three subjects completed the protocol.
Compared with the control group, the net changes in systolic blood pressure and diastolic blood pressure were -5 mmHg and -3 mmHg, respectively, after the 8-week intervention.
The corresponding net change in renin activity was -1.1 ng/mL/h for the nattokinase group compared with the control group.
In conclusion, nattokinase supplementation resulted in a reduction in systolic blood pressure and diastolic blood pressure.
These findings suggest that increased intake of nattokinase may play an important role in preventing and treating hypertension.
Nattokinase acts as a natural ACE (angiotensin converting enzyme) inhibitor to reduce blood pressure, without the side-effects of prescription ACE inhibitors such as persistent dry cough.
Proteolytic EnzymeNattokinase is primarily used as a proteolytic enzyme, or systemic enzyme, which works best taken on an empty stomach where it is quickly absorbed into the bloodstream.
Nattokinase then starts breaking down protein molecules in the blood into more benign forms, and enhances the body's natural ability to fight blood clots.
Because Nattokinase closely resembles plasmin, it dissolves fibrin directly, and also enhances production of both plasmin and other clot-dissolving agents, including urokinase (endogenous). 17 clinical studies have verified that Nattokinase dissolves existing clots and prevents new ones from forming.
According to Dr. Martin Milner of the Center for Natural Medicine in Portland, Oregon, "In some ways, nattokinase is actually superior to conventional clot-dissolving drugs. T-PAs (tissue plasminogen activators) like urokinase (the drug), are only effective when taken intravenously and often fail simply because a stroke or heart attack victim's arteries have hardened beyond the point where they can be treated by any other clot-dissolving agent. Nattokinase, however, can help prevent that hardening with an oral dose of as little as 100 mg a day."
It doesn't just help with clotting either. Studies have shown that nattokinase can work to help lower blood pressure by -- a key factor in hypertension -- from narrowing blood vessels. In human trials, nattokinase has been shown to lead to a ten percent drop in overall blood pressure readings.
Other Nattokinase BenefitsAthsma, Chronic Rhinosinusitis, Nasal Polyps, COPD and other respiratory conditions can be improved with Nattokinase.
By breaking down fibrin in mucosal fluids, better flow is established, reducing risk for many respiratory issues.
Read more at Dr. Murry's Nattokinase article.
Even more benefits:
- Joint and muscle pain
- Inhibiting hardening of arteries
- Breaking down unwanted wastes in the blood
- Breaking down undigested proteins in the gut
- Increasing natural plasmin production
- May help prevent varicose veins, muscle spasms and pain
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Open2Study, Australia - Food, Nutrition and Your Health
RMIT University, Australia - Foundations of Psychology
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University of Washington, USA - Energy, Diet and Weight
Johns Hopkins Bloomberg School of Public Health, USA - Health Issues for Aging Populations
Johns Hopkins Bloomberg School of Public Health, USA - International Nutrition
Johns Hopkins Bloomberg School of Public Health, USA - Methods in Biostatistics I
Johns Hopkins Bloomberg School of Public Health, USA - Methods in Biostatistics II
Johns Hopkins Bloomberg School of Public Health, USA - Principles of Human Nutrition
TUFTS University, USA - Nutrition and Medicine
TUFTS University, USA - Lipids/Cardiovascular Disease I and Lipids/Cardiovascular Disease II
Technical Learning College, USA - Western Herbology, Identification, Formulas
Bath University, England - Inside Cancer
WebMD Education - The Link Between Stroke and Atrial Fibrillation
WebMD Education - High Potassium: Causes and Reasons to Treat
Leiden University Medical Center, Netherlands - Anatomy of the Abdomen and Pelvis
MIT (Massachusetts Institute of Technology) - A Clinical Approach to the Human Brain
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Updated 12th August 2018, Copyright © 1999-2019 Brenton Wight and BJ & HJ Wight trading as Lean Machine abn 55293601285