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Iron Overload Destroys Mitochondria and Sabotages Health


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2020/01/15/iron-overload-destroys-mitochondria.aspx

Analysis by Dr. Joseph Mercola Fact Checked image
January 15, 2020
iron overload destroys mitochondria

STORY AT-A-GLANCE

  • Iron is essential for life as it transfers oxygen to your tissues. Hemoglobin, the protein in your red blood cells, contains iron at its core, which reversibly binds to oxygen and supplies your tissues with it
  • Without proper oxygenation, your cells quickly start dying. However, excess iron can also cause severe problems by encouraging oxidation and tissue damage
  • Common health problems associated with elevated iron levels include cirrhosis, cancer, hepatitis C, gouty arthritis, arrhythmia, cardiovascular disease, Type 2 diabetes, Alzheimer’s and more
  • Recent research shows excessive iron damages mitochondrial function and impairs your heart function by inducing the death of muscle cells in your heart
  • Your iron level can be easily determined with a serum ferritin test. I believe this is one of the most important tests that everyone should have done on a regular basis as part of a preventive, proactive health screen

Iron is necessary for life as it essential to transfer oxygen into your tissues. Hemoglobin, the protein in your red blood cells that contains iron at its core, reversibly binds to oxygen and supplies your tissues with it. Without proper oxygenation, your cells quickly start dying.

Iron is also a key component of various proteins and enzymes, and is involved in energy production, immune function, metabolism and endocrine function. For these reasons, low iron (anemia) can cause significant health problems.

However, what many don’t realize is that excess iron is actually more common than too little, and iron overload can be even more problematic, as detailed in “Why Managing Your Iron Level Is Crucial to Your Health,” which features my interview with Gerry Koenig, former chairman of the Iron Disorders Institute and the Hemochromatosis Foundation.

Because your body has a limited capacity to excrete iron, it can easily build up in organs like your liver, heart and pancreas. This is dangerous because iron is a potent oxidizer that can damage your tissues and contribute to a variety of health problems, including but not limited to:

Cirrhosis1 Cancer, including bowel,2 liver3 and lung cancer4 — Elevated ferritin is associated with a 2.9 times higher risk of death from cancer5 and blood donors have been shown to have a lower likelihood of developing certain cancers than nondonors6,7
Hepatitis C8 — As noted in a 2007 paper,9 even “mild or moderate increase of iron stores appears to have significant clinical relevance” in this and other conditions Gouty arthritis10
Cardiac arrhythmia11 Cardiovascular disease12
Type 2 diabetes13 and metabolic syndrome — Elevated ferritin has been linked to dysfunctional glucose metabolism,14 raising the risk of diabetes fivefold in men and fourfold in women, a magnitude of correlation similar to that of obesity.15

High ferritin also doubles your risk of metabolic syndrome,16 a condition associated with an increased risk of high blood pressure, liver disease and heart disease

Alzheimer’s disease17

Iron Overload Impairs Mitochondrial Function

Iron causes significant harm primarily by catalyzing a reaction within the inner mitochondrial membrane. When iron reacts with hydrogen peroxide, hydroxyl free radicals are formed.

These are among the most damaging free radicals known, causing severe mitochondrial dysfunction, which in turn is at the heart of most chronic degenerative diseases. The hydroxyl free radicals are an oxidative stress that will also damage your cell membranes, stem cells, protein and DNA.

In addition to all this damage, recent research18 shows excessive iron also promotes apoptosis and ferroptosis in cardiomyocytes. Apoptosis is the programmed cell death of diseased and worn-out cells, and as the name implies, ferroptosis refers to cell death that is dependent on and regulated by iron specifically.19

Cardiomyocytes are muscle cells in your heart that generate and control the rhythmic contractions in your heart, thus allowing it to maintain a healthy rhythm.20 In short, this tells us that excess iron has the ability to impair your heart function by inducing mitochondrial abnormalities and the death of muscle cells in your heart.

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How Iron Overload Affects Your Risk of Alzheimer’s Disease

Aside from raising your risk of heart-related problems, iron overload is also of particular concern in Alzheimer’s disease,21,22,23 the prevalence of which has dramatically risen in recent decades.

According to research24,25 published in 2018, buildup of iron — which increases oxidative stress and has a type of “rusting effect” in your brain — is common in most Alzheimer’s patients. As noted by the authors:26

“In the presence of the pathological hallmarks of [Alzheimer’s disease], iron is accumulated within and around the amyloid-beta plaques and neurofibrillary tangles, mostly as ferrihydrite inside ferritin, hemosiderin and magnetite.

The co-localization of iron with amyloid-beta has been proposed to constitute a major source of toxicity. Indeed, in vitro, amyloid-beta has been shown to convert ferric iron to ferrous iron, which can act as a catalyst for the Fenton reaction to generate toxic free radicals, which in turn result in oxidative stress.”

Other research 27 suggests elevated cerebrospinal fluid iron levels are strongly correlated with the presence of the Alzheimer’s risk allele APOE-e4, and that elevated levels of iron in your brain may actually be the mechanism that makes APOE-e4 a major genetic risk factor for the disease.

A primary focus of conventional treatment so far has been to clear amyloid proteins, but while that approach seems logical, such attempts have met with limited success.

Researchers now suggest clearing out excess iron may be a more effective way to reduce damage and slow or prevent the Alzheimer’s disease process. You can learn more about this in “How Excess Iron Raises Your Risk for Alzheimer’s.”

Iron Dysregulation Is Surprisingly Common

It’s easy to get too much iron as it’s commonly added to most multivitamins. Many processed foods are also fortified with iron. Two servings of fortified breakfast cereal may provide as much as 44 milligrams (mg) of iron in some cases,28 bringing you dangerously close to the upper tolerance limit of 45 mg for adults, and well over the recommended daily allowance, which is a mere 8 mg for men and 18 mg for premenopausal women (i.e., women who still get their monthly period).29

Unfortunately, many doctors don’t understand or appreciate the importance of checking for iron overload. One of the greatest risk factors for iron overload is having a condition called hemochromatosis30 — one of the most prevalent genetic diseases in the U.S. — which impairs your body’s iron regulation, causing you to absorb higher than normal amounts.

The C282Y gene mutation is thought to be responsible for the majority of hemochromatosis cases. It takes two inherited copies of the mutation (one from your mother and one from your father) to cause the disease (and even then, only some people will actually get sick).

More than 30% of Americans are thought to have two copies of this defective gene31 and, according to one study,32 an estimated 40% to 70% of those with two defective C282Y genes will develop clinical evidence of iron overload.

If you have just one copy, you won’t become ill but you will still absorb slightly more iron than the rest of the population,33,34 thus placing you at increased risk for overload and the complications associated with it.

Common Factors That Increase Your Risk of Iron Overload

Virtually all adult men and postmenopausal women are also at risk for iron overload since they do not lose blood on a regular basis. Blood loss is the primary way to lower excess iron, as the body has no active excretion mechanisms. Other potential contributors to high iron levels include:

  • Cooking in iron pots or pans — Cooking acidic foods in these types of pots or pans will elevate iron absorption.
  • Eating processed food products like cereals and white breads fortified with iron — The iron used in these products is inorganic iron, not much different from rust, and it is far more dangerous than the iron in meat.
  • Drinking well water that is high in iron — The key here is to make sure you have some type of iron precipitator and/or a reverse osmosis water filter.
  • Taking multiple vitamins and mineral supplements, as both of these frequently have iron in them.
  • Regularly consuming alcohol, as this will increase the absorption of iron in your diet.

How to Check for and Address Iron Overload

Checking your iron levels is easy and can be done with a simple blood test called a serum ferritin test. I believe this is one of the most important tests that everyone should have done on a regular basis as part of a preventive, proactive health screen. The test measures the carrier molecule of iron, a protein found inside cells called ferritin, which stores the iron. If your ferritin levels are low, it means your iron levels are also low.

The healthy range of serum ferritin lies between 20 and 80 nanograms per milliliter (ng/ml). Below 20 ng/ml is a strong indicator that you are iron deficient, and above 80 ng/ml suggests you have an iron surplus. An ideal range is between 40 and 60 ng/ml.

Please note that many health sites will tell you that “normal” can be much higher than that, but as I discuss with Koenig in the earlier referenced article, levels over 300 ng/ml are particularly toxic and will eventually cause serious damage.

If you have hemochromatosis, or if a serum ferritin blood test reveals elevated iron levels, donating your blood two or three times a year is the safest, most effective and inexpensive remedy. If you have severe overload you may need to do more regular phlebotomies.

If, for some reason, a blood donor center is unable to accept your blood for donation, you can obtain a prescription for therapeutic phlebotomy. At the same time, you’ll also want to avoid consuming excess iron in the form of supplements, in your drinking water (well water), from iron cookware or fortified processed foods.

You can also limit iron absorption by not eating iron-rich foods in combination with vitamin C-rich foods or beverages, as the vitamin C boosts iron absorption. If needed, you could also take a curcumin supplement. Curcumin acts as a potent chelator of iron and can be a useful supplement if your iron is elevated.

GGT Test Is Also Advisable to Rule Out Iron Toxicity

Aside from a serum ferritin test, a gamma-glutamyl transpeptidase (GGT) test can also be used as a screening marker for excess free iron and is a great indicator of your risk for sudden cardiac death, insulin resistance, cardiometabolic disease35 and chronic kidney disease36 as well.

In recent years, scientists have discovered GGT is highly interactive with iron. Low GGT tends to be protective against higher ferritin, so if your GGT is low, you’re largely protected even if your ferritin is a bit higher than ideal.

When both your serum ferritin and GGT are high, you are at significantly increased risk of chronic health problems and early death,37,38 because then you have a combination of free iron (which is highly toxic), and the iron storage to keep that toxicity going.39 That said, even if your ferritin is low, having elevated GGT levels is cause for concern and needs to be addressed.

For this reason, getting a GGT test in addition to a serum ferritin test is advisable to rule out iron toxicity. The ideal level of GGT is below 16 units per liter (U/L) for men and below 9 U/L for women. Above 25 U/L for men and 18 U/L for women, your risk of chronic disease increases significantly.

To lower your GGT level you’ll need to implement strategies that boost glutathione, a potent antioxidant produced in your body, as GGT is inversely related to glutathione. As your GGT level rises, your glutathione goes down. This is in fact part of the equation explaining how elevated GGT harms your health. By elevating your glutathione level, you will lower your GGT.

The amino acid cysteine, found in whey protein, poultry and eggs, plays an important role in your body’s production of glutathione. Red meat, which does not contain cysteine, will tend to raise GGT, as will alcohol, so both should be avoided.40

Certain medications can also raise your GGT. If this is the case, please confer with your doctor to determine whether you might be able to stop the medication or switch to something else. General detoxification is another important component if your GGT is high, as your liver’s job is to remove toxins from your body. The fact that your GGT is elevated means your liver is under stress.

Annual Ferritin Test Is an Important Health Screen

For adults, I strongly recommend getting an annual serum ferritin test to confirm you’re neither too high nor too low. When it comes to iron overload, I believe it can be every bit as dangerous to your health as vitamin D deficiency, and checking your iron status is far more important than your cholesterol.

While a full iron panel that checks serum iron, iron-binding capacity and ferritin can be helpful, you really only need the serum ferritin test, plus the GGT test. Your doctor can write you a prescription for these tests, or you can order them from HealtheIron.com.

Again, if your ferritin is high, the easiest way to lower it is to donate blood two or three times a year. U.S. legislation allows all blood banks to perform therapeutic phlebotomy for hemochromatosis or iron overload. All you need is a doctor’s order.

Also, unless you have a lab-documented iron deficiency, avoid iron-containing multivitamins, iron supplements and mineral supplements that contain iron if your levels are already high.

– Sources and References

Addressing EMF Pollution — A 21st Century Health Imperative


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2020/01/22/emf-pollution.aspx

Analysis by Dr. Joseph Mercola Fact Checked image
January 22, 2020

STORY AT-A-GLANCE

  • The primary danger of electromagnetic fields (EMFs) — and what drives the processes of chronic disease — is the mitochondrial damage triggered by peroxynitrites
  • Peroxynitrites are potent reactive nitrogen species associated with systemic inflammation and mitochondrial dysfunction, and are thought to be a root cause for many of today’s chronic diseases
  • You cannot see, hear or smell EMF, and most do not feel it. Still, biological effects are taking place whether you’re able to sense it or not
  • The number of people reporting pathological hypersensitivity to EMFs is rising. Between 1994 and 2008, prevalence of electromagnetic hypersensitivity syndrome in Austria rose from 2% to 3.5%. In 2011, Taiwan reported an incidence rate of 13.3%
  • The possibility of large portions of the population being unable to work or live as free individuals due to incessant, elevated exposure to EMF is a very real threat to society as we know it. There are very few EMF-free zones left on the planet, and such zones will further shrink with the global implementation of 5G

Over the past decade, I’ve written many articles discussing the evidence of biological harm from nonionizing electromagnetic field (EMF) radiation.

While the wireless industry is built on the premise that the only type of radiation capable of causing harm is ionizing — X-rays being one example — researchers have for a long time warned that even nonionizing and non-heating radiation can jeopardize your health. This includes not only human health, but also that of plants and animals.

Over time, I became so convinced of the deleterious effects of EMF, I took three years to write “EMF*D,” which is slated to be released in February 2020. In it, I review the now overwhelming evidence showing EMFs are a hidden health hazard that simply cannot be ignored any longer, especially seeing how the rollout of 5G will exponentially increase exposures.

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Scientists Now Understand How EMFs Impact Your Health

Over the years, I’ve interviewed several experts who have shared their in-depth knowledge about the poorly understood mechanisms behind EMF harm. Among them:

Martin Pall, Ph.D., Professor Emeritus of biochemistry and basic medical sciences at Washington State University, has published research1,2,3,4 showing that the primary danger of EMFs — and what drives the processes of chronic disease — is the mitochondrial damage triggered by peroxynitrites, one of the most damaging types of reactive nitrogen species.

Low-frequency microwave radiation activates the voltage-gated calcium channels (VGCCs) in the outer membrane of your cells, causing them to open, thus allowing an abnormal influx of calcium ions. This activates nitric oxide, which is a precursor for peroxynitrite.5

These potent reactive nitrogen species are associated with an increased level of systemic inflammation and mitochondrial dysfunction, and are thought to be a root cause for many of today’s chronic diseases.

For an in-depth understanding of peroxynitrites and the harm they inflict, see “Nitric Oxide and Peroxynitrite in Health and Disease”6 by Dr. Pal Pacher, Joseph Beckman and Dr. Lucas Liaudet. It’s one of the best reviews I’ve ever read and free to download.

One of its most significant downsides of peroxynitrite is that it damages DNA. While your body has the capacity to repair that damage through a family of enzymes collectively known as poly ADP ribose polymerases (PARP), PARP require NAD+ for fuel, and when they run out of NAD+ they stop repairing your DNA, which can lead to premature cell death.

Dr. Sam Milham, a physician and epidemiologist, wrote the book, “Dirty Electricity: Electrification and the Diseases of Civilization.” In his interview, he explains the biological mechanisms of high-frequency electric transients (electromagnetic interference patterns), and details some of the lesser-known household sources of this “dirty electricity.”

Magda Havas, Ph.D., associate professor at Trent University in Canada, has written research including the effects dirty electricity can have on children’s behavior, and helpful remediation techniques.

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EMF Pollution Is Likely Taking a Hidden Toll on Your Health

The problem with EMF radiation is that you cannot see it, hear it or smell it, and most do not feel it. Still, researchers assure us that biological effects are taking place whether you’re able to sense it or not. For most, it’s simply a matter of time and overall exposure load.

Here, it’s important to realize that we’re not just talking about radiation from your cellphone. The electromagnetic frequencies emitted from your Wi-Fi router, computer, home appliances, all manner of wireless “smart” technology, and even the wiring inside your walls are all capable of inflicting serious biological harm to your body and mind. And with 5G, it’s bound to get far worse.

Electromagnetic Hypersensitivity Syndrome Is on the Rise

For some, the effects of EMFs are unmistakable and undeniable, and the number of people reporting pathological hypersensitivity to EMFs is rising. In 2008, an Austrian study7 noted that actual prevalence of electromagnetic hypersensitivity syndrome in Austria had risen by 1.5% since 1994, from 2% to 3.5%.

In 2006, Germany had an electrosensitivity incidence rate of 9%, and Taiwan reported an incidence rate of 13.3% in 2011.8 The RT documentary “Wi-Fi Refugees,” featured in “Documentary Explore Electromagnetic Hypersensitivity Syndrome,” investigates the struggles reported by these “canaries in the coal mine.”

While symptoms may vary from one individual to another, commonly reported symptoms of electromagnetic hypersensitivity syndrome include:

  1. Skin itch/rash/flushing/burning and/or tingling — Many describe a “burning pins and needles” kind of pain, especially in the head and chest area
  2. Confusion/poor concentration and/or memory loss
  3. Fatigue and muscle weakness
  4. Headache
  5. Chest pain and heart problems

Other reported symptoms include:

Ear pain Panic attacks
Insomnia Seizures
Tinnitus (ringing in the ears) Feeling a vibration in the body
Paralysis Unrelenting dizziness

One 2015 study9 pointed out that electromagnetic hypersensitivity is becoming an increasing challenge to the medical profession, which has yet to fully understand its implications, let alone its remedies.

Still, the complaints of modern-day hypersensitivities match those reported in the 1970s and ’80s by those working with radio and radar equipment and cathode ray tube monitors, which tells us that this is not a brand-new phenomenon. According to the authors:10

“In population-based surveys, the prevalence of EHS has ranged from 1.5% in Sweden to 13.3% in Taiwan. Provocation studies on EMF have yielded different results, ranging from where people with EHS cannot discriminate between an active RF signal and placebo, to objectively observed changes following exposure in reactions of the pupil, changes in heart rhythm, damage to erythrocytes, and disturbed glucose metabolism in the brain.”

As early as 2005, the World Health Organization warned that people have “for some time” reported health problems attributed to EMF exposure, and that some are “so severely affected that they cease work and change their entire lifestyle.”11

The possibility of large portions of the population being unable to work or live as free individuals due to incessant, elevated exposure to EMF is a very real threat to society as we know it. The reality is that there are very few EMF-free zones left on the planet, and such zones will further shrink with the global implementation of 5G.

‘EMF*D’

I believe EMF exposure is one of the greatest challenges to public health facing us today. If we go back in time to the end of World War I, around 1918 or so, and use that timeframe as a baseline of EMF exposure among the general public, you come to the astonishing conclusion that EMF exposure has increased about 1 quintillion times over the past 100 years.

Knowing the impact EMFs can have, it’s completely irrational to assume that this radical increase won’t have adverse effects. My new book, “EMF*D,” is an attempt to inform you about the hidden harms of EMF and what you need to do to protect yourself and those you love. In it, you’ll learn:

  • How EMFs are impacting your body and mind
  • Where you can find them in your daily life
  • How they can cause disease and speed up aging
  • How to repair the damage done by EMFs at the cellular level
  • Practical strategies to protect yourself and your loved ones from EMFs

In my book, I also reveal the reasons why you’ve been left in the dark about this serious health threat. “EMF*D” comes out February 18, 2020, but you don’t need to wait. Preorder your copy today and receive these five bonus gifts immediately:

  • Early access to a chapter from the book
  • $10 discount on a Mercola order
  • 30-page Sneak Peak PDF Book
  • 7 strategies to help reduce EMF exposure
  • 5 tips to minimize your cellphone risk (SMS exclusive bonus)
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Brain Cancer Is Not the Only, Nor the Major, Concern

While a number of studies have shown that cellphone radiation can trigger brain cancer this is not the greatest cause for concern. Your brain does have a far greater density of VGCCs than other organs, but so does your nervous system and heart, as well as male testes.

As a result of the elevated density of VGCCs in these areas, EMFs are likely to contribute to neurological and neuropsychiatric problems,12 as well as heart and reproductive problems, including but not limited to cardiac arrhythmias, anxietydepressionautismAlzheimer’s and infertility13,14 and miscarriage15,16,17,18 — and these conditions are far more prevalent than brain cancer.

That said, studies have also linked radiofrequency radiation equivalent to that emitted by 2G and 3G cellphones to other forms of cancer, including heart tumors. This includes U.S. government-funded animal studies19 published in 2018 that were further corroborated by the Ramazzini Institute that same year.20

As early as 2011, the evidence was strong enough for the International Agency for Research on Cancer, the cancer research arm of the WHO, to declare cellphones a Group 2B “possible carcinogen.”21

I’ve already mentioned one of the primary mechanisms by which EMFs harm your biology — i.e., the creation of peroxynitrites, which are potent oxidant stressors — but EMFs also damage your health in other ways.

For example, the enzyme ATP synthase — which passes currents of protons into the mitochondrial intermembrane space, similar to current passing through a wire — powers the generation energy of the creation of ATP from ADP, using this flow of protons.

Magnetic fields can change the transparency of the flow of protons to the mitochondrial intermembrane space, thereby reducing the current. As a result, you get less ATP, which can have system wide consequences, from promoting chronic disease and infertility to lowering intelligence.

EMFs may also alter your microbiome, turning what might otherwise be beneficial microbes pathogenic or toxic. This too can have far-ranging health effects, since we now know your microbiome plays an important role in health.

5G Rollout Will Significantly Magnify Health Risks

Any and all health ramifications attributed to previous generations of wireless technologies will be exponentially magnified with the rollout of 5G, which is simply being added on top of the already existing wireless infrastructure. This 5th generation technology may also present additional health risks.

A main concern with 5G is that it relies primarily on the bandwidth of the millimeter wave (MMW), which is known to penetrate 1 to 2 millimeters of human skin tissue.22 There’s also evidence suggesting sweat ducts in human skin act as antennae when they come in contact with MMWs.23

Many can feel the impact of MMWs as a burning sensation and/or pain, which is precisely why it’s used in nonlethal crowd control weapons.24 MMW has also been linked to eye problems, suppressed immune function and altered heart rate variability (an indicator of stress) and arrhythmias.25

In 2015, more than 230 scientists engaged in the study of biological and health effects of nonionizing EMFs in 41 nations signed an international appeal to the United Nations, calling for protection from nonionizing EMF exposure due to evidence of health effects even at low levels.26

Two years later, more than 180 doctors and scientists from 35 countries signed a petition27 to enact a moratorium on the rollout of 5G due to the potential risks to wildlife and human health.

Dr. Mercola Answers Your EMF Questions

Dr. Mercola Answers Your EMF Questions

I believe that the risk of EMFs is so important that I’ve decided to answer your questions on this topic in an upcoming video. Please submit any EMF questions you may have by clicking on the button below.

preorder emfd

The earlier I get the questions, the greater the likelihood I will have a chance to include them in my response. Looking forward to answering your questions!

Protect Yourself From Excessive EMF

There’s no doubt in my mind that EMF exposure is an important lifestyle component that needs to be addressed if you’re concerned about your health, which is why I spent three years writing “EMF*D.”

My aim was to create a comprehensive and informative guide, detailing not only the risks, but also what you can do to mitigate unavoidable exposures. To get you started, see the tips listed in my previous article, “Top 19 Tips to Reduce Your EMF Exposure.”

If you know or suspect you might already be developing a sensitivity to EMFs (full-blown hypersensitivity can often strike seemingly overnight), mitigating your exposures will be particularly paramount. Many sufferers become obsessed with finding solutions, as the effects can be severely crippling. My book can be a valuable resource in your quest for relief.

The EMF Experts website28 also lists EMF groups worldwide, to which you can turn with questions, concerns and support, and EMFsafehome.com29 lists a number of publications where you can learn more about the dangers of EMFs.

Should you need help remediating your home, consider hiring a trained building biologist to get it done right. A listing can be found on the International Institute for Building-Biology & Ecology’s website.30

– Sources and References

Alzheimer’s Prevention

Written by Brenton Wight, researcher and LeanMachine

Copyright © Brenton Wight, LeanMachine

Doctors say there is no cure for Alzheimer’s Disease, in spite of over 80 billion dollars in research over the last few decades.
This is partly true, as there is no drug, no “magic bullet” to slow or stop this dreadful condition.
Hundreds of studies with new drugs have shown most of the time that those on a placebo did BETTER than those on the drug!
In rare cases, those on the drug did very slightly better, but any improvement was not enough to justify bringing the drug to market.
However, we CAN identify risk factors, and we CAN in most cases prevent the onset of Alzheimer’s, and we CAN in most cases reverse the disease, or at least ease the symptoms to give the patient and the carers a better quality of life.
If the intervention is soon enough, it CAN be CURED in some, but not all cases.
There is no miracle one-shot treatment, but a combination of many factors.
The time to start treatment is not when we are 60 and forget where the keys are, but from birth!
The lifetime changes we need to prevent Alzheimer’s will also prevent heart disease, diabetes, cancer and many other diseases, and give our lives vitality.

How many people are at risk?

In the USA, over 5 million Americans have Alzheimer’s disease, and around 14% of the population will eventually get Alzheimer’s, or around 45 million people.
Results in Australia are similar. Over 10% of the population over 65 have Alzheimer’s, and 30% of those over 85 have Alzheimer’s. In the decade from 2010 to 2020, deaths from Alzheimer’s has risen 20% and looks set to replace Cardiovascular disease as the Number 1 cause of death.
Many people now suffer from Early Onset Alzheimer’s, showing signs as young as 30 years of age.
In the USA, it is now the third leading cause of death, but these figures are understated. People do not actually die from Alzheimer’s – they die because the parts of the brain that control bodily functions shut down, so they die when their organs shut down.
The patient may die from pneumonia because the lungs now cannot function or some other organ fails to work and the Doctor or Coroner has to determine which organ failed.
This is a problem in every country, but some countries have very much reduced rates of Alzheimer’s, mainly due to better diets and reduced toxins.

Diagnosis

Originally, there was no firm diagnosis without examining the brains of patients after death.
Researchers found that most patients had Amyloid Plaques in the brain, and also high levels of aluminium.
PET scans (Positron Emission Tomography) are used with a radioactive tracer (which binds to amyloid plaques) to determine the amount and location of amyloid plaques in the brain.
However, this diagnosis is still not conclusive, as many people have amyloid plaques, but no sign of any dementia even into old age, although these people have a higher risk. Often symptoms do not appear for decades after the start of amyloid plaque deposits. Other patients have no sign of Amyloid plaques but still have Alzheimer’s, so drugs developed to reduce Amyloid plaques have proven unsuccessful in prevention and treatment.
Standard blood tests for glucose level, triglycerides, kidney and liver function can help determine the risk. However, those with less than optimum blood results may die of Cardiovascular, Cancer or some other disease before Alzheimer’s sets in.
So the PET scan is used with other tests for cognitive performance to arrive at a diagnosis.

Who is at risk?

Genetics plays an important part, and so does diet, exercise, lifestyle and supplements.
Here are some risk factors, in no particular order:

  • Age is the greatest risk factor. Dementia can affect about 10% of those over the age of 65, but 33% of those over 80
  • Gender – Women represent over 60% of Alzheimer’s patients, but part of this may be due to their longer lifespans
  • Gluten – Celiacs often have “Wheat Brain” causing disturbances, anxiety, depression and Alzheimer’s. Many dementia patients recover fully on a gluten free diet
  • Prescription medications such as many sedatives, hypnotics, blood pressure, hay fever, insomnia, depression and arthritis medications are linked to higher risk of Alzheimer’s
  • Anaesthetics are linked to Alzheimer’s. The more operations people have, the higher the risk
  • High Blood Pressure (systolic over 140 in mid-life) doubles the risk of Alzheimer’s and increases vascular dementia by 600%, but blood pressure medications can be just as bad, so reduce it naturally without medication
  • Sleep Apnea starves the brain of vital oxygen and increases risk of Alzheimer’s
  • B-12 deficiency increases Alzheimer’s risk. Gastric Bypass Surgery, Celiac disease, vegan/vegetarian diets, antacids (like Nexium) and many medications all reduce availability and/or absorption of B-12
  • Diabetes doubles the risk of Alzheimer’s (often called “Diabetes of the Brain” or “Type 3 Diabetes”)
  • Vision problems increase Alzheimer’s risk. Opthalmologists can detect abnormal widths of blood vessels in the retina which can indicate early Alzheimer’s
  • Tobacco – Smokers have double the risk for Alzheimer’s. Family and others breathing second-hand smoke also have higher risk
  • Living alone after a partner’s death means we have six times the risk of Alzheimer’s, and those who divorce and live alone have three times the risk.
  • Isolation is a significant risk factor for depression and dementia. Find a friend!
  • Obesity is a risk. The lower the BMI (Body Mass Index) the lower the risk. Obesity raises risk by around 75%
  • Family history increases the risk. See the Genetics section below, but environmental factors, diet and lifestyle choices can be passed on to children
  • Education improves outcome, and lack of education increases Alzheimer’s risk. Studies suggest higher education increases “cognitive reserve” which may offset dementia symptoms
  • Concussion or head trauma increases Alzheimer’s risk exponentially with the number and severity of head injuries
  • Quality sleep is essential for the ability of the body to repair itself by flushing toxins from the brain
  • Excessive alcohol consumption can lead to alcoholic dementia and higher risk of Alzheimer’s as well as many other health risks
  • Mental activities improves the brain, physically and psychologically. Learn new things strengthens and develops new nerve cells
  • Sedentary lifestyles are a large risk for the brain as well as the body. Exercise is a must for the brain and the body
  • Chronic bladder disease increases risk
  • Chronic Candida infections increase risk

Overcoming risk factors:

  • Change the diet – see below
  • Get regular, uninterrupted sleep
  • Socialising, visiting friends, joining a group
  • Crosswords, puzzles, new experiences, learning a musical instrument or another language
  • Exercise helps control blood glucose levels, keeps excess weight down, increases oxygen and circulation, and joining a gym can also help with socialisation
  • Use the many supplements available

Genetics

There is a strong genetic predisposition to Alzheimer’s, but also there is a strong contribution of environment, diet and lifestyle.
Rates of Alzheimer’s disease have increased much faster than any genetic changes could have occurred.
This means that much is under our control, because even with a genetic predisposition, we can reduce risk with epigenetic (non-genetic influences on gene expression) changes.
Example: The most important genetic risk factor is the ApoE epsilon 4 allele (ApoE4), and 14% to 18% of the population has this gene.
Everyone carries two copies of the APOE gene, which makes the protein ApoE (apolipoprotein E).
There are three different types (alleles) of the APOE gene: E2, E3 and E4, and because we all have two copies of the gene, the combination determines our APOE “genotype” which can be any combination of the 2 copies: E2/E2, E2/E3, E2/E4, E3/E3, E3/E4, or E4/E4.
The majority of people have two E3 alleles (E3/E3) so this is defined as the “average risk”.
The E2 allele is the least common form, and if we have two E2 alleles (E2/E2) or one E2 and one E3 (E2/E3) we have about 40% REDUCED risk of Alzheimer’s.
The E4 allele, present in 14% to 20% of the population, increases the risk for Alzheimer’s, especially late-onset Alzheimer’s, but this does NOT mean that we will get Alzheimer’s disease if we have one or two copies of E4, as about one third of Alzheimer’s patients do not have even a single E4.
All it means is that our risk is increased, also increased is the risk of potential Alzheimer’s at a younger age.
To quantify the risk:
If we have no copies of E4, we still have around 9% risk of Alzheimer’s.
If we have a single copy of E4, our risk increases to around 30%.
If we have two copies of E4, risk is between 50% to 90% but in all cases, we CAN REDUCE the risk.
Many people are horrified to learn that they have up to a 90% risk of Alzheimer’s, but they need not be.
With some dietary, lifestyle and supplement changes, those at greatest risk can easily fall into the 10% who do NOT get Alzheimer’s.

SAD (Standard American Diet)

Genetic statistics above apply only to average people, typically Caucasians living in the Western World and consuming a typical Western diet of processed food, sugar, MSG, hydrogenated oils, chemicals, heavy metals, pesticides, insecticides and other toxic substances.
These statistics do NOT apply to those with a healthy diet of natural, organic food living in a low-toxin environment.
In fact, many people already down the cognitive decline have recovered on a healthy diet and sustained the improvement for several years, according to Dr Dale Bredesen who has been running a program for years now.
Dr Bredesen does not know how many more years it will be, but does know that patients on the program have removed the biochemical drivers which can be measured in blood tests, so so is very optimistic about their future health for many years to come.

Should we get genetic testing?

This is up to the individual. Some people would prefer not to know. Others want to know.
My father died from Alzheimer’s at about age 72 after many years in a Nursing Home, existing but without knowing who his family members were. So did my Grandmother on my Mother’s side, so I assume I may well have inherited a high genetic risk. I am now 73 as I revise this article. For me, testing is irrelevant, because I changed to a Paleo-style diet at age 63, which turned my life around.
From obese to lean, from grey hair to brown, from allergies to everything to allergies to nothing, from high blood pressure and triglycerides to normal, from poor physical strength to strong, fit and full of energy, from frequent headaches to none, from always getting sick to never getting sick.
If I had the genetic test and it was the worst result, I would only continue to do what I am doing now, using dietary and lifestyle modifications.
Have I halted Alzheimers? I hope so, but I often cannot remember some of the thousands of medical terms I have come across in my 10 years of research.  Come back here in 27 years as I approach 100 and I will let you know how I have done.

Amyloid Plaques vs Tangles

Amyloid is a protein, normally found throughout the body. In Alzheimer’s, this protein divides improperly, creating beta amyloid which is toxic to brain neurons.
Amyloid is actually antimicrobial and has benefits for the body, but some people, especially those with the E4/E4 alleles cannot naturally break down these plaques, but there are dietary methods which can.
Not all Alzheimer’s patients have beta Amyloid plaques. About 10% of patients have neurofibrillary tangles which cause similar symptoms, but are also inclined to have more aggressive behavior.

Three Kinds of Alzheimer’s

Humans liberate amyloid as a protective response in the body to three different fundamental metabolic and toxic perturbations:

  • Type 1: Characterized by systemic inflammation. Blood tests typically reveal high hs-CRP (high-sensitivity C-reactive protein), low albumin:globulin ratio,
    and high cytokine levels such as interleukin-1 and interleukin-6. Imaging reveals temporoparietal reductions in glucose utilization.
    Those at risk include people with chronic infections or inflammation from other causes, and the normal antimicrobial protective response liberates amyloids
  • Type 2: Characterized by normal inflammation, but an atrophic (wasting away) profile, with reduced support from estradiol, progesterone, testosterone, insulin, and vitamin D, often with high homocysteine and insulin resistance. Imaging reveals temporoparietal reductions in glucose utilization. As NGF (Nerve Growth Factor) diminishes, amyloid production increases.
    Type 2 in particular can be CAUSED by LOW cholesterol, resulting in atrophy (brain shrinkage), reduced hormone production, poor health and eventually Alzheimer’s.
    All because we are taking statins that lower cholesterol, or we are not eating enough healthy fats.
    We prevent our cells from doing what they are supposed to do, so we end up with a shrunken brain without the lipid (fat) content we need. A fat-free diet means atrophy of the brain.
    See the Cholesterol Fraud and the Big Fat Lie sections below.
  • Type 3: Different from types 1 and 2. Still β-amyloid positive and phospho-tau positive), but a younger onset (late 40s to early 60s).
    Genotype ApoE is usually E3/E3 instead of E4/E4 or E3/E4 with little or no family history.
    Onset usually follows a period of stress, depression, sleep loss, anesthesia, or menopause/andropause.
    Memory loss is not a main symptom, instead there are cortical issues: dyscalculia (trouble with arithmetic), aphasia (trouble speaking or understanding speech – damage to the left side of the brain),
    executive dysfunction (emotional or behavioural problems from frontal lobe issues).
    Imaging studies often reveal extra-hippocampal disease, greater general cerebral atrophy and frontal-temporal-parietal abnormalities.
    Lab results often reveal hypozincemia (low zinc) and/or a high copper:zinc ratio, and can indictate adrenal fatigue
    (low pregnenolone, DHEA-S (dehydroepiandrosterone sulfate), and/or AM cortisol. Chronic infections like mycotoxins, Lyme, viral infections, HSV-1 (a herpes simplex virus) are all risk factors


Some patients have “Alzheimer’s type 1.5” where a combination of symptoms of both type 1 and 2 Alzheimer’s occurs.
Glycotoxicity (too much sugar in the brain) causes an insulin resistant brain. Combine this with AGEs (Advanced Glycation End products), and we have both inflammation from AGEs, plus atrophic withdrawal response because we are now resistant to insulin.
So we have a double condition of type 1 and type 2.

Type 3 patients often have MARCoNS (Multiple Antibiotic-Resistant Coagulase-Negative Staph), a colonisation of antibiotic-resistant staphylococcus in the nasal cavity.
Also high blood levels of TGF-beta-1 (Transforming Growth Factor beta-1), high C4A (a protein that in humans is encoded by the C4A gene), and low MSH (Melanocyte-Stimulating Hormone) is very common, typically with HLA-DR/DQ haplotypes shown by Dr Ritchie Shoemaker to be associated with CIRS.

Alzheimer’s from nose infections?

We have known for years that our healthy gut bacteria is essential to prevent almost every disease, and now research is looking at the rhinosinal microbiome, the healthy bacteria in our nose.
This is now becoming known as Inhalational Alzheimer’s.
The nose is the most direct route to the brain, and bad bacteria in the mucous lining of the airways can damage the brain.
Pathologists now believe there are unknown pathogens in the rhinencephalon, the “nose-smell” (olfacation) system.
Many Alzheimer’s patients start losing their sense of smell as one of the early signs of the disease, and this is probably why.
I am confident that my nasal bacteria is back to normal after having very bad allergies and taking antihistamines from when I was about 16 to when I was 63.
Allergies stopped when the bad diet stopped.

Dr. Susan Lynch at UCSF has found that the nose problem is not so much an unknown pathogen, but a lack of microbial diversity.
Beneficial microorganisms in the nose protect against many pathogens, and one of the best seems to be Lactobacillus sakei, used to make sake and kimchi.
This could explain why Japanese people have comparatively low rates of Alzheimer’s, although rates are rising in Japan because of the Western influence, with meat and dairy replacing rice as a staple food.
When Japanese people migrate to Western countries and adopt a Western diet, they have the same risk as anyone else.
So for the Japanese, it is not a genetic problem, but a diet problem, and this applies to everyone.

AGEs – Advanced Glycation End products

AGEs are formed when food cooked at high temperatures (over 120 degrees C) combines with sugar. AGEs are very damaging to the body, accelerating the ageing process and chronic disease.
AGEs worsen diabetes, kidney disease, Alzheimer’s, inflammation, atherosclerosis (stiffening of the arteries), cardiovascular disease and stroke.
AGEs cause glycation of LDL cholesterol, promoting oxidation, and oxidized LDL is a major factor in atherosclerosis.
AGEs form photosensitizers in the eye lens, leading to cataract development.

To reduce AGEs, never cook at high temperatures (steaming is best, always at 100 degrees C), eat plenty of raw food (salads, and small amounts of fruit), and eliminate all sugar and processed foods.

Conventional Drugs

Drug companies have been trying for years to get rid of Amyloid plaques, thinking they are the cause of Alzheimer’s.
However, the body needs amyloid to protect the brain, so we need to look at what is causing the plaques instead of trying to get rid of them. Latest research shows that Amyloid plaques are antimicrobial, so can be both damaging and protecting!

 

Alzheimer’s – “Diabetes Type 3”

Some researchers are now labeling Alzheimer’s as “Diabetes Type 3” because sugar causes Alzheimer’s.
Sugar also causes diabetes, cardiovascular disease, obesity and many more diseases, mainly due to processed foods.
As with diabetes, where sugar causes insulin resistance, we have insulin resistance in the brain, causing degeneration.
When the brain becomes insulin resistant, it means that glucose cannot enter the brain cells, so those cells die.
However, all is not lost. If we switch to a Ketonegic diet, we can feed our brain with fat instead of sugar. More on this diet below.

Diagnosing the type of Alzheimer’s

Unlike cancer, where we can biopsy a tumour, we must look at historical, biochemical, genetic, imaging, and function information to determine the type of Alzheimer’s.
Of course this rarely happens except in research applications. The doctor simply says the patient has Alzheimer’s and may give a drug which in the long term will not make much difference.
This is a shame, because about half of all cases can be halted, and in some cases substantially improved, by reverting to the correct diet.
Even better would be to eat a correct diet from birth, reducing the risk of Alzheimer’s to near zero, as well as preventing cancer, heart disease, diabetes and other modern diseases.

Exercise

Physical exercise is extremely important to keep the brain and body healthy.
Researchers are not sure why, but LeanMachine says it is obvious:
Exercise burns off the high glucose levels that cause “Diabetes of the Brain” and exercise boosts oxygen levels and circulation in the brain.
Any type of exercise is beneficial, such as:

  • Walking, jogging or running
  • Calisthenics
  • Squats
  • Push-ups, chin-ups
  • Skipping
  • Gardening

Exercises have the added benefit of socialisation in a group, such as:

  • Join a gym
  • Tai-Chi or Yoga classes
  • Athletics clubs
  • Dancing classes

Exercising the Brain

The body has a disturbing property: Anything not used for a while gets broken down to be used somewhere else.
If we do not use a muscle for a week, the body starts breaking it down.
But if we exercise regularly, we stop muscles wasting, and we actually build up our muscles.
If we do not use parts of the brain, the body starts breaking it down.
But if we exercise our brain, we can hang on to the parts we use, and develop new pathways to replace parts we have lost. Exercises such as:

  • Learning a new language
  • Playing a musical instrument
  • Crossword or other puzzles
  • Socialising in groups or clubs

Meditation

Meditation is not normally seen as exercise for the brain, but sitting in a quiet, dark room away from all daily distractions not only promotes a calming effect, but increases various brain-saving hormones.
Meditation, like dreaming, helps the brain sort out the junk memories and recent problems by concentrating on things that have made us feel good in the past.
We may have pleasant memories like sitting on a sandy beach listening to the waves rolling in on a beautiful sunny day. By concentrating on peaceful and pleasant memories, we forget problems with out hectic daily life.

Supplements

The modern diet is lacking in vitamins, minerals, amino acids and other nutrients, mainly because of:

  • Over-farming – growing the same food in the same ground year after year, depleting these vital elements
  • Over-processing – hydrogenation, adding sugar, adding chemicals, overheating
  • Toxins from farming chemicals contaminates the environment
  • Water is contaminated by fluoride and chlorine

The supplements everyone over 50 should take are:
Organic Coconut Oil, taken several times a day, a tablespoon at a time.
LeanMachine considers this one of the best prevention and treatment methods available for Alzheimer’s.
This encourages the body to burn healthy fats instead of sugar, called the Ketogenic Diet which burns ketones, which is what our ancestors did in their natural low-carb diets. See the Ketogenic Diet below.
Coconut oil appears to break down the amyloid plaque buildup in the brain. Perhaps the plaques are no longer required when the brain is fed by healthy fats instead of glucose.
Coconut oil is also the absolute best for cooking, replacing any other fat, because coconut oil remains stable at high temperatures, and is full of MCT (Medium Chain Triglycerides) which go straight to the liver to be burned as fuel, and cannot be stored as fat in the body.
Coconut oil also contains Lauric Acid, which keeps our skin wrinkle-free and healthy.

PS (Phosphatidylserene) is a component of the cerebral cortex’s neuronal membrane, and can improve memory and mood, reduce stress, improve learning and more.
It does this by controlling input and production of choline, acetylcholine, norepinephrine, dopamine and glucose.

NAC (N-Acetyl Cysteine) which helps the body make Glutathione, the body’s natural “Master Antioxidant” that fights cancer, Alzheimer’s and many other conditions.

Curcumin is the active ingredient in Turmeric which has been used for thousands of years for dementia, cancer and many other conditions.

Vitamin B-12 because as we age, our stomach acid levels drop, preventing the high-acid conditions required for B-12 absorption from food. Even more essential for vegans and vegetarians as B-12 mainly comes from animal products.

B-group vitamins because these are vitally important for nerves and brain health.

ALA (Alpha Lipoic Acid) as an antioxidant to help remove heavy metals from the brain, reduce inflammation, and improve the effectiveness of votamins C and E.

Vitamin D3 because over half the ageing population are taking statin medication (which they should NOT) and statins halt production of 7-dehydrocholesterol, the first step in the manufacture of vitamin D3. Worse, many of these seniors are in Aged Care facilities and never see the light of day, so cannot make vitamin D3 from sunlight. If they are ever taken outside, it is only early morning or late afternoon when they cannot get vitamin D3 anyway. More info in my Vitamin D3 article.

Ginkgo Biloba is highly recommended to improve blood flow in the brain. Should not be used in conjunction with prescription blood thinners.

TMG (Trimethylglycine) is an effective methyl donor for the facilitation of methylation processes. Supports a healthy homocysteine level, which in turn supports healthy cardiovascular function and helps prevent Alzheimer’s. Homocysteine, a damaging amino acid, with the aid of TMG, is turned into methionine, a safe and beneficial amino acid. Methylation is essential for DNA repair and production of SAMe, which helps joints, lifts mood, fights depression and protects brain cells from amyloid plaques. Read more in my TMG article.

SAMe (S-Adenosyl Methionine) can help protect the brain and also help treat depression, anger, anxiety which are common symptoms in some Alzheimer’s patients.

Vinpocetine has shown mixed results but mostly beneficial in limited human trials using 10mg 3 times daily.

Vitamin E is recommended to improve the healthy fats in the brain and increase antioxidants.

Benfotiamine with Leucine can help remove glucose and improve insulin resistance.

Many other supplements can help, including:

In addition, many supplements primarily used to treat diabetes will also help prevent Alzheimer’s.

The Cholesterol Fraud

Previous research indicated that high cholesterol was a risk factor for Alzheimer’s.
Again, this was wrong. Doctors started prescribing statin drugs for those people with high cholesterol, or those with signs of dementia with normal cholesterol.
What happened? They got Alzheimer’s WORSE and got it FASTER than patients who did NOT take statins.
Researchers only looked at total cholesterol which is a complete waste of time.

25% of the cholesterol in the body is in the brain, mainly in the myelin sheath.
Around 60% of our brain is fat, mainly in the form of cholesterol.
The myelin sheath (oligodendroglia) that surrounds and protects our neurons are 70% cholesterol, 30% protein.
Starve the brain of healthy fat, and we get Alzheimer’s. Almost guaranteed.
Reduce cholesterol and what happens? The protective myelin sheaths break down as they are starved of cholesterol, allowing the brain cells to be damaged. Damage them enough, and they die. Then we have dementia. Damage enough cells, and the brain can no longer support our basic functions, like breathing. Then we die.
This is why statin drugs are BAD.
Sure, in some cases, they can slightly reduce risk of heart attacks, but they INCREASE death from all other causes, including Alzheimer’s.
The net result is that on average, we will not live a day longer on statin medication.
Statins will give us lousy final years with muscle breakdown, osteoporosis, more sickness and dementia.
We need plenty of healthy fats like coconut oil, walnuts, avocados, fish, eggs, butter from grass-fed cows, unheated olive oil.
We must NOT consume bad fats: Canola oil, margarine, anything hydrogenated, anything heated over 120 degrees C.
Cholesterol is NOT the enemy.
We NEED cholesterol, especially HDL (High Density Lipoprotein) cholesterol which reduces inflammation, and helps clean up the body (like a garbage collector). Without HDL Cholesterol, we die within 24 hours.
We also need LDL (Low Density Lipoprotein), still incorrectly called “bad” cholesterol, as we die without it.
LDL has antimicrobial effects, so the idea that we should drive it down to zero is ludicrous. LDL is essential to transport nutrients around the body (and into the brain) as well as helping the body manufacture hormones and other important products. LDL was essential for our evolutionary ancestors millions of years ago, and we still need it.
The brain is mostly fat, and 40% of the brain is CHOLESTEROL.
Many things that were protective in our native environment are problems in our modern environment, but if we go back to our ancestral diet, problems are resolved.
Studies show time after time that people with low cholesterol die young, while people with normal to high cholesterol live longest.
These studies are ignored by the big drug companies. Because statin sales make them billions of dollars, of course they continue the Big Cholesterol Lie, one of the biggest frauds in medical history. Their own study showed increased deaths and terrible side effects so they stopped the study short at that time, supposedly to “save patient’s lives” when the opposite was true.

The dangerous cholesterol is VLDL (Very Low Density Lipoprotein) which cannot easily be tested.
Because triglycerides contain some VLDL, labs estimate VLDL value by simply taking a percentage of triglycerides.
High triglycerides are much more of a danger signal than high cholesterol, and are almost always related to obesity, poor diet of processed foods, especially dangerous fats.

The Big Fat Lie

We have been told for decades that fat is bad for us.
Forget about “low fat” or “fat free” diets.
Another big fat lie, coming from a scientist who plucked figures out of a study to suit an argument he was proposing.
When the data was analysed completely, many decades later, it showed the complete opposite.
The largest and longest study in the world was the Framingham study which showed that those who ate the most fat lived longer than those who ate the least.
Fat is not unhealthy in general, in fact it is essential for health.
The UNHEALTHY fats are man-made artificial fats (margarine, Canola oil) and other processed fats that are hydrogenated to improve shelf life and heated to extremes during manufacture, often going rancid in the process, causing oxidised VLDL (Very Low Density Lipoprotein), the REAL dangerous “food”.
What is REALLY bad is carbohydrates, and when manufacturers remove fats from food, they replace them with carbohydrates, causing most “modern” diseases including Alzheimer’s and Diabetes.

The Ketogenic Diet

For the first two million years of human life on Earth, carbohydrate consumption was very low.
Carbohydrates were uncommon, with the majority of food being nuts, seeds, eggs, fish, fruit and vegetables. Meat was eaten very rarely when an animal was killed.
These people did not burn carbohydrates for energy, they burned FAT. In particular, ketones, the basis of the ketogenic diet.
A ketogenic diet means maintaining a fasting state of ketosis. Ketones are produced when the body is in a state of ketosis.
Ketones fuel cells using a different pathway from glucose.
Glucose has to have insulin to allow glucose into cells, but as we all should know, our typical modern diet is loaded with carbohydrates, forcing the pancreas into overdrive making enough insulin.
Eventually our cells become insulin resistant, so the pancreas produces even more insulin to force glucose into the cells, creating even more insulin resistance.
We are now a full-blown diabetic, and when the pancreas starts shutting down, we need insulin injections for the rest of our life.
However, when we feed the cells with ketones, they simply enter the cell naturally, and do NOT require insulin or anything else to do so.
This is critically important for five of our modern diseases: Obesity, Cancer, Diabetes, Cardiovascular and Alzheimer’s, all caused or aggravated by high blood glucose, bad fats and inflammation.
Ketones are also signaling molecules as well.

Benefits of the ketogenic diet include:

  • Helps the body express new restorative and healing genes
  • Reduces inflammation (underlying cause of nearly every disease)
  • Stimulates the immune system
  • Aids weight loss
  • Stops or slows degenerative disease
  • Reduces risk of Alzheimer’s, Cancer, Cardiovascular, Diabetes and Obesity

The Anti-Alzheimer’s diet

Spices

Add these spices to every meal possible.
Of course they will spice up any meal, but also help clear the brain of problems and reduce risk of cardiovascular disease, cancer, diabetes and many more modern illnesses.

  • Sage – one of the best brain-saving spices
  • Cloves – one of the most potent antioxidants
  • Curry – a blend of other great spices
  • Ginger – reduces inflammation and improves immunity
  • Turmeric – for colour, flavour and Curcumin
  • Ceylon Cinnamon – Better and safer than regular cinnamon

Ketogenic Diet – Healthy fats, intermittent fasting.
Read How Cyclical Ketosis can help combat Chronic Fatigue

Avoid Trans Fats
Read Trans Fats Linked to Increased Risk for Alzheimers

Avoid Processed Foods
Only shop in the greengrocer department at the Supermarket, preferably the organic section. Buy or grow your own real food. Nothing in a bag, box, tin because toxic ingredients are sure to be added.

Avoid AGEs
Forget fried foods. Steaming is the best way to cook. Never Microwave. Eat raw salads daily.


This section often updated. Please come back soon (if you remember!)

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Updated 20th January 2020, Copyright © 1999-2020 Brenton Wight and BJ&HJ Wight trading as Lean Machine abn 55293601285

Vigorous Exercise Leads to Lower Mortality for Women


Reproduced from original article:
https://fitness.mercola.com/sites/fitness/archive/2020/01/10/vigorous-exercise-benefits.aspx
Analysis by Dr. Joseph Mercola Fact Checked image
January 10, 2020

health benefits of vigorous exercise

STORY AT-A-GLANCE

  • Heart disease and cancer are the two top reasons people die in the U.S.; data show women who can exercise vigorously have a reduced risk of mortality from heart disease, cancer and other causes
  • Women who have high cardiovascular fitness also enjoy a reduced risk of dementia, which may be related to higher levels of a protein responsible for improving mitochondrial biogenesis
  • Combining intermittent fasting with the ketogenic diet plan may boost the health benefits and improve mitochondrial health. This includes not eating within three hours of going to bed to reduce free radical damage
  • Lack of exercise is globally responsible for nearly 5 million deaths each year; the more you move and exercise the lower the potential rate of death. Aim to sit as little as possible during the day

Heart disease and cancer are the top two reasons people die in the U.S. The term heart disease is used to identify several types of conditions, including cardiovascular disease, coronary artery disease and heart attack. While many think of this as a man’s disease, the CDC1 reports almost as many women will die each year from it.

The most common type, coronary heart disease, affects 6.2% of women 20 and older. Many women report having no symptoms before experiencing a heart attack, but others may have symptoms of angina, nausea or fatigue. Diabetesobesity, an unhealthy diet and lack of physical activity are all lifestyle choices that increase your risk for heart disease.

Each of these same factors increase your risk of cancer. Some of the types of cancer that more frequently affect women include breast, cervical, lung, colorectal and skin.2 Most cancers strike women after menopause, but gynecological cancers may happen at any time.

Every year 90,000 women are diagnosed with one form of gynecological cancer and 242,000 with breast cancer. The signs of gynecological cancers may be vague and mimic symptoms of other conditions, such as unexplained weight loss, constant fatigue, loss of appetite or feeling full, pain in the pelvis or a change in bowel habits.

Fitness Protects Women Against Risk of Premature Death

New data recently presented at the European Society of Cardiology3 strongly suggest that women who can exercise vigorously experience a significantly lower risk of mortality from heart disease, cancer and other causes. Although there have been multiple studies using male participants or mixed groups, the researchers proposed that information specific to women was scarce.

The study used data from 4,714 adult females who had undergone echocardiograms for known or suspected coronary artery disease. Treadmill stress tests were used with increasing intensity to measure fitness, which the researchers defined as a maximum workload of 10 metabolic equivalents (METs).

Women who were able to achieve 10 METs or more were compared to those who achieved less. A measurement of 10 METs is equivalent to walking up four flights of stairs fast without stopping or going up three flights quickly.

The researchers followed the participants for a median 4.6 years and found there were 345 deaths from cardiovascular disease, 164 from cancer and 203 from other causes. After adjusting for influencing factors, the findings revealed that women in the higher MET group had a lower risk of death from all measured causes.

By comparison, women in the lower fitness group experienced an annual rate of death nearly four times higher and the annual cancer death rate doubled. One researcher, Dr. Jesus Peteiro, noted the average age of participants was 64 years and 80% were from 50 to 75 years. He went on to comment:4

“Good exercise capacity predicted lower risk of death from cardiovascular disease, cancer, and other causes. Looking at both examinations together, women whose heart works normally during exercise are unlikely to have a cardiovascular event.

But if their exercise capacity is poor, they are still at risk of death from cancer or other causes. The best situation is to have normal heart performance during exercise and good exercise capacity.”

The women underwent imaging of their heart during the treadmill test to assess function. Those with poor function during the test were more likely to succumb to cardiovascular disease during the follow-up period, but it was not predictive of death from other causes.5 Peteiro said: “The results were the same for women over 60 and less than 60, although the group under 50 was small.”

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Cardiovascular Fitness Also Reduces Risk of Dementia

Staying fit is key to reducing your potential risk for many chronic diseases, including those affecting the central nervous system. Across the world there are 47 million who are living with dementia, and this is expected to increase to 75 million by 2030. You may be able to significantly slash this risk by taking simple steps to improve your cardiovascular fitness.

A study from the University of Gothenburg in Sweden showed women with the highest cardiovascular fitness had an 88% reduced risk of dementia as compared to those with moderate fitness. Even maintaining some fitness proved to have benefit as those with the lowest level experienced a 41% greater risk of dementia than those with average fitness.

The researchers did not assess how much exercise the participants engaged in but used an ergometer cycling test during which additional resistance was added as the women continued to cycle until they were exhausted. The authors wrote:

“These results suggest that cardiovascular fitness is associated with the sparing of brain tissue in aging humans. Furthermore, these results suggest a strong biological basis for the role of aerobic fitness in maintaining and enhancing central nervous system health and cognitive functioning in older adults.”

A second way fitness may protect neurological health is by increasing levels of PGC-1alpha responsible for improving mitochondrial biogenesis. Data reveal that those with Alzheimer’s have less PGC-1alpha in their brain. Cells containing more produce less of the toxic amyloid protein associated with the development of Alzheimer’s disease.

Participants diagnosed with mild to moderate Alzheimer’s were enrolled in a four-month supervised exercise program. The results demonstrated they had fewer neuropsychiatric symptoms from the disease than the control group who did not exercise.

A progressive walking program in those with early Alzheimer’s disease led to improvements in cardiovascular fitness and functional ability. This in turn led to improved memory and increases in the size of the brain’s hippocampus.

Mitochondrial Function Linked to Reducing Risk of Disease

Your mitochondria are minute powerhouses in your cells producing a majority of the energy your body generates, as well as coordinating apoptosis, or programmed cell death, important in the prevention of malfunctioning cells that may turn into cancer.

Your brain is the most energy-dependent organ and therefore is particularly susceptible to impaired energy production. This process may then make the brain more susceptible to age-related disease.

As you age, the genes controlling mitochondrial energy generation may be turned down, and mitochondria are noted to be less dense and more fragmented. With insufficient energy and dysfunctional mitochondria, defective cells can survive and multiply.

There are several ways your mitochondria may be damaged, but much of it may result from superoxide free radicals. Although the production of superoxide is part of a normal process, when produced at higher than normal levels it damages the DNA in your mitochondria. This damage increases when you are not metabolically flexible.

That means you burn a higher percentage of carbohydrates for fuel than you do fat. The process of burning carbs leaks more electrons that combine with oxygen to form superoxide. High-carbohydrate processed foods prevent you from burning fat efficiently, which produces less oxidative stress than carbs. Your nutrition is also foundational to protecting your mitochondrial health.

Combining Nutritional Plan With Fitness Boosts Benefits

When you combine a strong nutritional plan to boost metabolic flexibility with cardiovascular fitness you build on the health benefits of both. For many years the standard dietary recommendations were three square meals a day with small snacks in between.

The most obvious risk of this eating plan is the potential of overeating. But, the less obvious risk is metabolic dysfunction, raising your risk of cancer, heart disease and dementia.

For a number of years, I have strongly advised against eating within three hours of going to bed. The authors of one study found that eating an early dinner, or skipping it entirely, changes the way the body metabolizes fat and carbohydrates. This improves fat burning and reduces hunger. The key in the study was eating the last meal of the day by the middle of the afternoon.

The only changes made to the participants’ meals was timing. The total number and types of calories remained the same. Results showed the participants were less hungry and experienced increased fat burning during the evening hours, along with improved metabolic flexibility. It appears that late night eating will boost free radical damage, negatively impacting mitochondrial function.

By taking advantage of your circadian rhythm you optimize your metabolism. During sleep your body requires less energy. Thus, if you eat right before bed, mitochondria produce excessive amounts of free radicals. In one study of 1,800 people with prostate and breast cancer, researchers found that meal timing reduced the risk of cancer.

They also found that those who awakened early had a higher risk of cancer when they ate dinner late in the evening compared to those who were more energetic at night. A very effective option is to combine intermittent fasting, extend the amount of time you go without food and follow a ketogenic diet.

Fasting upregulates autophagy and mitochondrial health, activating stem cells and stimulating mitochondrial biosynthesis. What many don’t realize is that many of these benefits happen during the refeeding phase, making what you eat foods that are essential to your optimal health.

In one study participants lost 3% of their body weight while practicing time restricted eating even though they didn’t change their nutritional choices. While they lost weight, they did not improve important disease parameters, including visceral fat, diastolic blood pressure, triglycerides, fasting glucose or fasting insulin.

When intermittent fasting is combined with a ketogenic diet it provides many of the same benefits of fasting, in addition to improvements in health such as increased muscle mass, improved insulin sensitivity, reduced inflammation, reduced risk of cancer and increased longevity.

Lack of Exercise May Be Worse Than Smoking

Exercise and nutrition are two of the best preventive strategies against many common health conditions. In one study scientists found that the lack of physical activity came with a global price tag of $67.5 billion in 2013 and that it causes more than 5 million deaths each year, while smoking kills 6 million.

Another group of researchers analyzed data on more than 120,000 people and found that cardiovascular fitness had a greater impact on risk of death than smoking, diabetes or heart disease. However, as important as cardiovascular fitness is, you’ll find you can’t out-exercise the number of hours you sit down.

The average U.S. adult will sit nine to 12 hours each day. While sitting is not inherently dangerous, the cumulative effects on your cardiovascular and musculoskeletal system can seriously impact your health and shorten your life.

In a four-year evaluation of 8,000 Americans over the age of 45, researchers found that those who moved more were healthier. There was also a correlation between death rate and the number of hours the participants spent sitting each day. The bare minimum of movement is 10 minutes for every hour of sitting. However, it is wiser to strive to sit as little as possible.

Sitting correctly requires greater muscle activation and will reduce your potential risk of lower back pain and strain. For specific instructions on how to sit right and for a list of some of the negative side effects of sitting for long periods, see “The Importance of Standing More, Sitting Less.”

Sources and References

Excess Body Fat Can Age Your Brain Faster Than Muscle


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2020/01/09/obesity-and-brain-health.aspx
Analysis by Dr. Joseph Mercola Fact Checked image
January 09, 2020

excess body fat and brain health

STORY AT-A-GLANCE

  • Increasing research shows that maintaining healthy levels of body fat and greater muscle mass has an effect on your brain health and may slow your rate of cognitive aging
  • People with higher amounts of abdominal fat had worse fluid intelligence with age, while those with greater muscle mass were more protected against such declines
  • Women who had greater muscle mass tended to have better scores in fluid intelligence during the study period
  • Past research has linked midlife obesity with an increased risk of mild cognitive impairment, changes in short-term memory and executive functioning and dementia
  • In addition to regular exercise to increase muscle mass, eating a ketogenic diet to maintain a healthy body weight and avoid obesity may support your brain health as you age

Staying fit as you age is about far more than aesthetics. Increasing research shows that maintaining healthy levels of body fat and greater muscle mass has an effect on your brain health and even your rate of cognitive aging. It’s known, for instance, that being obese in midlife and early late-life is associated with worse cognitive aging.1

What’s more, the amount of muscle and fat you have may be a more important factor in how your level of fluid intelligence decreases over time than your chronological age. Your chronological age, i.e., your age in years, is just a numerical measurement, but your real age is your biological age as dictated by your choices and habits, as well as your modifiable risk factors like levels of muscle and fat.

While many people tend to gain fat and lose muscle mass as they age, this can be largely combated by staying active and eating right — lifestyle choices that will influence your cognitive function significantly.

More Muscle, Less Fat Protects Your Brain

In a study by Iowa State researchers, data from 4,431 adults were examined to compare levels of lean muscle mass, abdominal fat and subcutaneous fat with changes in fluid intelligence — the ability to solve problems in new situations — over a six-year period.2,3

Those with higher amounts of abdominal fat had worse fluid intelligence with age, while those with greater muscle mass were more protected against such declines. In fact, women who had greater muscle mass tended to have better scores in fluid intelligence during the study period.

Study co-author Auriel Willette, assistant professor of food science and human nutrition at Iowa State University, said in a news release, “Chronological age doesn’t seem to be a factor in fluid intelligence decreasing over time. It appears to be biological age, which here is the amount of fat and muscle.”4

What’s more, the study revealed a link between the immune system and how changes in fat levels affect cognition. Previous research suggests a higher body mass index (BMI) leads to greater immune system activity in the blood, which in turn activates the immune system in the brain, with a negative outcome on cognitive function.5

The featured study also found that changes in white blood cells called lymphocytes and eosinophils explained the link between abdominal fat and worsening fluid intelligence in women. In men, basophils, another type of white blood cell, were linked to about half of the link between fat levels and fluid intelligence, the study found.6

“Lymphocytes, eosinophils, and basophils may link adiposity to cognitive outcomes,” the researchers explained.7 Similar research has revealed that overweight and obese individual have greater brain atrophy in middle-age, corresponding with an increase in brain age of 10 years.8

How Obesity Affects Your Brain

Obesity has multiple effects on the brain, including anatomically speaking. Obese individuals may have reduced gray matter in brain regions such as the hippocampus, prefrontal cortex and other subcortical regions. Atrophy in the hippocampus, in turn, has been linked to Alzheimer’s disease.9

Gray matter is the outer layer of the brain associated with high-level brain functions such as problem-solving, language, memory, personality, planning and judgment. Even in elderly people who are otherwise cognitively normal, obesity is associated with measureable deficits in brain volume in the frontal lobes, anterior cingulate gyrus, hippocampus, and thalamus compared to individuals with a normal weight.10

Further research published in Radiology found that obesity may lead to alterations in brain structure, shrinking certain regions.11 Among men, higher total body fat percentage was linked to lower brain gray matter volume. Specifically, 5.5% greater total body fat percentage was associated with 3,162 mm3 lower gray matter volume.

Among men, 5.5% greater total body fat was also associated with 27 mm3 smaller globus pallidus volume, an association also seen in women. In women, 6.6% greater total body fat percentage was associated with 11.2 mm3 smaller globus pallidus volume.

The globus pallidus is a brain region that plays a role in supporting a range of functions, including motivation, cognition and action.12 Obesity was also associated with changes in white matter microstructure, which may be related to cognitive function.13

Cognitively speaking, there’s also a strong link between obesity and deterioration in cognitive function, as well as to other brain disorders such as dementia, anxiety and depression. Further, past research has linked midlife obesity with an increased risk of mild cognitive impairment, changes in short-term memory and executive functioning and dementia.14

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Obesity-Associated Health Problems Also Harm Your Brain

Obesity’s effects on brain health are also due to its associated health problems, including heart disease, diabetes and atherosclerosis, each of which can have its own deleterious effects on your brain. For instance, as noted in Frontiers in Neuroscience:15

“Obesity-derived vascular problems, such as atherosclerosis and arteriosclerosis, which are systemic diseases, are known to affect the steady blood flow of vessels that feed the brain, thus contributing to cognitive impairment or even stroke, where large areas of the brain die due to the stop in the blood flow of a major brain artery caused by a blood clot.”

In terms of diabetes, of which obesity is a key risk factor, having this condition in midlife is associated with a 19% greater cognitive decline over 20 years compared with not having the condition.16 Even those with prediabetes had significantly greater cognitive decline than those without.

Indeed, “Epidemiological studies have linked type-2 diabetes mellitus with cognitive impairment and dementia, with insulin resistance and hyperglycemia as the probable mechanistic links,” researchers noted.17

Coming full circle, eating a highly processed, junk food diet not only increases obesity risk but also can lead to normal but elevated blood sugar levels that, in turn, can lead to impaired glucose metabolism and Type 2 diabetes. Both diabetes and higher fasting glucose levels are linked with lower total brain volume.18

Impaired glucose metabolism is then associated with neurodegeneration that impairs cognitive function. This connection begins not in old age but much earlier, such that following a healthy lifestyle in young adulthood may be protective against cognitive decline later.19

The Inflammation Connection

Obesity can trigger chronic inflammation in your body, and chronic inflammation in your brain (neuroinflammation) is known to impair neurogenesis, your brain’s ability to adapt and grow new brain cells. It’s also linked to neurodegenerative disorders such as Alzheimer’s disease (AD), and it’s been suggested that “Obesity may serve as an amplifier or initiator of the chronic inflammation observed in AD patients.”20

Further, higher levels of inflammatory markers have also been associated with lower brain volume, including “greater atrophy than expected for age.”21 Excess body fat, particularly visceral fat, is also related to the release of proteins and hormones that can cause inflammation, which in turn can damage arteries and enter your liver, affecting how your body breaks down sugars and fats.

According to a study in the Annals of Neurology, “[A]dipose-tissue derived hormones, such as adiponectin, leptin, resistin or ghrelin, could also play a role in the relation between adipose tissue and brain atrophy.”22 Further, obesity may also be associated with lower volume in brain regions that regulate food-reward circuitry,23 possibly influencing overeating.

Strength Training Is Good for Your Brain

While obesity takes a toll on your brain, increased muscle mass protects it, which is likely one reason why strength training has been found to be beneficial for your brain. In other words, your body’s physical strength may serve as a marker of your brain power.

In fact, strength training is known to trigger beneficial neurobiological processes,24 leading to positive functional brain changes, including in the frontal lobe, with corresponding improvements in executive functions. One systematic review even found that strength training led to less white matter atrophy in the brain, with researchers noting:25

“Taken together, during aging processes, a substantial decline in muscular strength, especially in lower limb muscles, occurs, and accumulating evidence suggests that lower muscular strengths are linked to poorer cognitive performance.

Hence, resistance (strength) exercises (a single bout of resistance exercise, also referred to as acute exercise) and resistance (strength) training (more than one resistance exercise session, also referred to as chronic exercise … ) seem to be promising activities to ensure the preservation of physical functioning and cognitive functions with aging.”

Regular strength training, in addition to other forms of exercise and daily activity, is an important strategy for keeping your brain sharp and may help to offset some of the cognitive decline that occurs with age.

Avoid Obesity and Protect Your Brain With a Ketogenic Diet

While obesity may accelerate neurodegeneration, regular exercise to increase your muscle mass will be protective. Further, eating a ketogenic diet will help protect your brain from free radical damage and will supply the cells with preferred fuel while also helping you to lose weight and avoid obesity.

A ketogenic diet is high in healthy fats and low in net carbohydrates (total carbs minus fiber), prompting your body to start burning fat as its primary fuel, rather than sugar. This produces ketones, which not only burn efficiently but are also a superior fuel for your brain. Ketones also generate fewer reactive oxygen species (ROS) and less free-radical damage.

One of the simple strategies you can implement is to take ketone precursors like refined MCT oils of caprylic acid (C-8). The eight-chain carbon fats are readily converted to ketones. I personally use up to 5 ounces of our Ketone Energy when I have maxed out my protein and carb intake and need a source of healthy clean fat. This keeps my ketone level around 1 to 2.0 mmol/l. Just recognize that you have to build up to a high dose of MCT oil slowly or you will have problems with loose stools.

Recent studies have also demonstrated the benefits of nutritional ketosis for brain health. In one, researchers found a ketogenic diet improved neurovascular function, in part by improving your gut microbiome.26

In a second study, the researchers concluded a ketogenic diet acted as a veritable “fountain of youth” in their animal study by significantly improving neurovascular and metabolic functions, compared to the animals eating an unrestricted diet.27 Releasing ketones into your bloodstream helps preserve brain function and protects against cognitive impairment and other neurodegenerative diseases.28

KetoFasting, the program I developed and detail in my book, “KetoFast: A Step-By-Step Guide to Timing Your Ketogenic Meals,” combines a cyclical ketogenic diet and intermittent fasting with cyclical partial fasting to optimize health and longevity.

Not only can KetoFasting help you to lose weight, but your cognition typically improves thanks to the biological cleansing and regeneration that occurs throughout your body, including your brain.

Sources and References

TMG Benefits

TMG (Trimethylglycine) is a powerful nutrient, much like a vitamin, functioning as methyl donor, anti-oxidant, anti-inflammatory, energy booster, toxin remover, immune booster and more.
Also called betaine (first isolated from sugar beets) but different from Betaine Hydrochloride.

TMG the Methyl Donor

The TMG molecule comprises three methyl groups (CH3) joined to one molecule of glycine (C2H5NO2). The benefit of TMG is that it releases easily one, two, or all three of the methyl groups.
Releasing one methyl group then leaves behind DMG (Dimethylglycine) which is just TMG with only two methyl groups. Releasing all methyl groups leaves just Glycine, which is the smallest molecule of all of the amino acids, which allows it to go almost anywhere in the body, including crossing the blood-brain barrier.
DMG is considered a B-complex vitamin, shown to help:

  • Behaviour and speech in autistic children and adults
  • ADHD (Attention Deficit-Hyperactivity Disorder)
  • Neurological function
  • Reducing seizures
  • Stress tolerance
  • Oxygen utilisation
  • Liver activity
  • Athletic performance
  • Anti-aging
  • Anti-inflammatory
  • Anti-viral and anti-bacterial
  • Immune boosting
  • Shrinking tumours
  • Allergies
  • Chronic fatigue syndrome
  • Respiratory disorders
  • Alcoholism, drug addiction.
  • Cholesterol and triglycerides
  • Blood pressure
  • Blood glucose

Although DMG has all of these benefits, and is available as a supplement, LeanMachine recommends that people supplement with TMG as we then receive all of the benefits of DMG plus the benefit of 50% better methylation.

Methyl groups (CH3) are essential for millions of biochemical reactions every second in the body, these are a few examples:

  • Lowering homocysteine, an amino acid, which inflames arteries when levels rise, leading to “hardening of the arteries”. Homocysteine levels are a much better indicator of cardiovascular disease than cholesterol. High homocysteine is commonly caused by insufficient methyl groups. The body gets methyl groups from TMGActive FolateActive Vitamin B-12, SAM-eDMAEMethionineTaurine, Cysteine and Vitamin B-6.
    Other causes are mercury and copper toxicity. High homocysteine also causes methionine deficiency, in turn causing SAM-e (S-Adenosyl Methionine) deficiency which can lead to depression. Methionine is required for protein synthesis
  • Excess homocysteine also leads to osteoporosis, birth defects, cancer, ageing and free radicals, all helped by TMG
  • Methyl groups are required for the Phase 2, P450 liver detoxification pathway, a critical biochemical sequence of events. Fat-soluble toxins are joined to a methyl group, enabling a greater water solubility, then allowing the liver to remove them from the body. For toxins unable to be removed, methylation helps render them less toxic
  • TMG increases production of SAM-e, helping to reduce depression
  • TMG reduces risk of diabetes, as insulin release and insulin activity rely on methyl group donation
  • TMG donates methyl groups for protein synthesis (biosynthesis), the copying of genetic code from DNA to RNA (genetic transcription), then to the synthesis (formation) of every chemical in the body
  • TMG insufficiency causes biosynthesis slowing, telomeres shortening, and genetic errors (transcription errors) raises cancer risk from DNA mutations

The Methylation Process

This is a vital and most common chemical process in hundreds of essential chemical reactions, including:

  • Methylation is essential for manufacture of all the chemicals for the body
  • Stops certain viruses that could damage DNA
  • Stops the production of trophoblast (fast-growing cells that may lead to cancer)
  • Suppresses replication of DNA in areas where the body does not want it replicated
  • Important for neurological chemicals and blood chemicals
  • Corrects timing problems of the X chromosome in cell replication
  • Causea a genetic trait to come from only one parent, and not both
  • Prevents some genetic diseases
  • Helps prevent shortening of gene telomeres
  • Methylation is a primary method of removing toxins in the phase 2 liver detoxification system
  • Methylation converts toxins of all kinds from insoluble, less soluble or fat-soluble compounds into water-soluble compounds to allow excretion. Larger molecules are eliminated through the bile, smaller ones are excreted in the urine
  • Methylation is required for synthesis of dopamine and serotonin, improving mood, energy, wellbeing, alertness, concentration, and visual clarity
  • Methylation helps with liver detoxification
  • Methylation is required for conversion of homocysteine to methionine, which converts to other amino acids by various pathways
  • Methylation helps balance hormones such as estrogens, reducing risk of estrogen-related cancers
  • Reduces inflammation by removing toxins, balancing hormones, synthesising neurotransmitters and other methods
  • Methylation protects the mitochondria and adaptive energy production to stop us from becoming very tired
  • Restores SAM-e in spinal fluid, working as a methyl donor when restored by methyl groups
  • Methylation is required for the body to make CoQ10 (Coenzyme Q10), vital for heart health and energy production in the mitochondria
  • Methylation increases muscle mass, important in cancer and other wasting diseases, and for general health
  • Methylation may improve libido in some people

Who needs TMG?

Almost everyone needs supplemental TMG, even healthy people with a healthy diet, to provide enough methylation for modern life. Those subject to stress, toxins, cardiovascular disease, mental illness, depression, fatigue, exhaustion or almost any other medical condition, almost certainly need extra TMG.

Other benefits of TMG

The Parasympathetic System

TMG can improve the parasympathetic system, helping balance the autonomic nervous system. Hair mineral analyses show about half the population has an autonomic nervous system imbalance (sympathetic dominance), where the sympathetic (fight-or-flight) nervous system is “switched on” too often and too long, usually due to stress, causing many chronic health conditions. TMG may help reverse any imbalance, contributing to healing. Some doctors use “sympathetic dominance” in a different context such as “a sympathetic state of body chemistry” which is different from “sympathetic dominance” used here.

The MTHFR Defect

Almost half the people on Earth have the abnormal MTHFR gene expression, where the biosynthesis of folate is reduced, sometimes marginally, sometimes largely.
Often incorrectly called a “genetic defect” when it is actually a transcription error, polymorphism or abnormal gene expression where errors occur in copying the DNA code rather than a problem with the actual DNA code.
This is why Active Folate has benefits, as it is already in the (6S)-5-methyltetrahydrofolate form required by the body, while regular folate must be converted in the body to this form.
TMG can help supply the methyl groups where insufficent folate cannot. Active folate can be up to 700% more useful in the body, compared to regular folic acid. Note that folic acid is a cheap folate substitute used in many foods claiming to be “folate enriched” but folic acid may prevent absorption of real folate in foods or active folate supplements, and LeanMachine advises total avoidance of foods or supplements containing folic acid.

Antioxidant and anti-inflammatory

There are not many reports on these properties, but they do exist, possibly as a result of methyl group donation

Effects on the Brain

TMG has a positive effect on the brain, likely due to methylation and SAM-e production. Recommended for those at high risk for Alzheimer’s, dementia, Parkinsons, depression, anxiety, seizures, migraine headache, ADHD (Attention Deficit-Hyperactivity Disorder), MS (Multiple Sclerosis) and other brain conditions.

SAM-e Benefits

1. Heart Disease

SAM-e is used for heart disease, also for fibromyalgia, abdominal pain, osteoarthritis, bursitis, tendonitis, chronic lower back pain, ageing, CFS (Chronic Fatigue Syndrome), improving mental performance, liver disease, spinal cord injury, lead poisoning, to break down bilirubin or porphyrin (or precursors).

2. PMS

SAM-e is often taken for PMS (Premenstrual Syndrome) and a more severe form PMDD (Premenstrual Dysphoric Disorder).

IV use of SAM-e

IV (Intravenous) use of SAM-e is used for depression, osteoarthritis, AIDS-related nervous system disorders, fibromyalgia, liver disease, cirrhosis, and intrahepatic cholestasis (a liver disorder in pregnant women)

SAM-e Injections

SAM-e is often injected for fibromyalgia, depression, and Alzheimer’s disease.

Effects on Digestion

TMG aids digestion, again likely because of positive methylation throughout the body.

Glycine

Glycine is the component left over when all three methyl groups have been donated from TMG.
Glycine is the smallest of the amino acids and very important for collagen formation and many other functions. Collagen, the most abundant protein in the body, is used for connective tissue: Tendons, ligaments, cartilage, skin, nails, arteries, veins, etc. Without collagen, we could not stand up, our body would be a pile of mush on the floor!
Glycine, in large doses (up to 3000 mg daily), has been found helpful for sleep and alertness. Although not recommended as a first-line supplement for sleep, it may help if other supplements like Valerian fail to work. This may explain why TMG helps induce restful sleep in some individuals.

Natural sources of TMG

TMG is normally made in the body, but not enough when there are toxins present or the diet is poor or absorption of nutrients is a problem.
TMG can come from the diet. Foods high in TMG include broccoli, quinoa, spinach, lamb, chicken, and beets. A vegetarian or vegan diet tends to be very low in TMG. Foods high in TMG are usually also high in folate, and both are methyl donors.
However, most people do not eat enough of these foods, and even eating large amounts will not provide enough TMG for optimum health.

Risk factors for low TMG

Generally, the body cannot make enough, the modern diet is poor in TMG, and the number of pesticides, chemicals, heavy metal contamination uses up all TMG available.

  • Mercury is a poison that lowers TMG production in the body, and at the same time increases the need for TMG in the body. Almost everyone is mercury toxic now, as mercury is everywhere in the environment, especially in seafood and in dental amalgam fillings
  • Copper toxicity also interferes with TMG, and most people today are toxic from copper pipes, tapware, cookware even if blood or urine tests are negative. While copper is essential for the body to build hemoglobin in blood, we need Chelated Copper from food or supplements, not metallic copper from copper pipes and cookware. Zinc deficiencies cause accumulation of copper in the body, and women have a higher risk than men. Causes headaches, female organ problems, depression, anxiety, skin conditions. Too much zinc (and/or magnesium) competes with copper for absorption, often leading to a copper deficiency.

Supplements

Supplementary TMG is helpful for most people because of low body production, low in the diet, and higher requirements in our toxic world.
TMG 1000mg 100 tablets (most popular, best value).

Stress

Stress, inflammation, inflammation and some diseases increase our need for more TMG.

Dosage of TMG

  • Women: Up to 1000 mg daily
  • Men: Up to 3000 mg daily
  • Children: Less than adults, in proportion to body weight

There are no reliable guides or tests to determine TMG dosage, but the figures above should be a good starting point.
If the sodium/potassium ratio is low, extra TMG may help.
Do not overdose, as too much TMG may lead to over-methylation, causing fatigue, nausea, hair loss, dizziness or other symptoms.
Most people have no side effects from TMG apart from feeling better, getting better sleep and having more energy.
Cautions:
Do not continue a high dose for extended periods.
Children need proportionately less TMG than adults, depending on their size and weight, but babies generally do not need TMG. Older children may need about 250 to 500 mg daily.
TMG is available as tablets, liquid capsules or crystals. Some children and the elderly may have problems with swallowing tablets. TMG has a sweet taste, so TMG crystals can be simply added to food.
Some people have problems tolerating TMG, so they may need a smaller dose. Try reducing the dose until any symptoms disappear.
People who have unresolved resentments seem to have more problems taking TMG, as an enzyme is activated which can cause anger, fear, depression or anxiety symptoms. These symptoms disappear if the dose is reduced or eliminated, but if one can tolerate the symptoms, TMG may help the person resolve their issues of conflict.
Some reports suggest that too much TMG may cause diarrhea and nausea, and may raise cholesterol levels, so those with high cholesterol should keep the level monitored.

Poor Methylation

Several factors affect poor methylation, such as:

  • Raw vegetables are considered healthy, but cooked vegetables provide more dietary methyl groups
  • Sugars in any form appear to harm correct methylation, and are bad for our health anyway
  • Fermented foods are healthy, but are problem for methylation because:
    • Some contain aldehydes (toxic to the liver), including kombucha tea, kimchi, and most fermented grains
    • They contain ferments, which are bacteria or yeasts

    Safer fermented foods, eaten in moderation, include yogurt, kefir, miso and most good quality cheeses

  • Too much animal protein in the diet can cause high methionine and reduce methylation
  • Fighting inflammation or infections consumes methyl groups, requiring more methylation
  • Heavy metal toxicity, especially copper and mercury, interfere with methyl group formation
  • High-dose niacin or niacinamide cause the body to use up methyl groups to detoxify and excrete niacin through the liver. Doses less than 50 mg daily are generally tolerated well
  • Any liver toxins will reduce formation of methyl donors, also liver detoxification pathways require methyl groups, using up more methyl groups
  • Methyl donor production seems to decrease with age, so seniors need more TMG
  • Women of child-bearing age have much better methylation than men. Men always need more TMG than women

Methylation and Cancer

Cancer increases the need for methylating agents like TMG. People often die with cancer because they cannot eliminate their toxic metals and chemicals because of poor liver methylation, so toxins accumulate until death occurs.

Hair Mineral Analysis

More TMG may be required if a hair mineral test reveals:

  • High zinc level, which may indicate presence of hidden toxic metals
  • “Four lows pattern” meaning all four electrolyte minerals low: Calcium, Magnesium, Sodium, Potassium. Indicates impaired methylation
  • High mercury, becoming more common
  • High copper
  • High levels of the other toxic metals

These results indicate long-term toxic metal exposure.

LeanMachine online supplemments

Disclaimer

LeanMachine is not a doctor, and everyone should consult with their own health professional before taking any product to ensure there is no conflict with existing prescription medication.
LeanMachine has been researching nutrition and health since 2010 and has completed many relevant studies including:
Open2Study, Australia – Food, Nutrition and Your Health
RMIT University, Australia – Foundations of Psychology
Swinburne University of Technology, Australia – Chemistry – Building Blocks of the World
University of Washington, USA – Energy, Diet and Weight
Johns Hopkins Bloomberg School of Public Health, USA – Health Issues for Aging Populations
Johns Hopkins Bloomberg School of Public Health, USA – International Nutrition
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics I
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics II
Johns Hopkins Bloomberg School of Public Health, USA – Principles of Human Nutrition
TUFTS University, USA – Nutrition and Medicine
TUFTS University, USA – Lipids/Cardiovascular Disease I and Lipids/Cardiovascular Disease II
Technical Learning College, USA – Western Herbology, Identification, Formulas
Bath University, England – Inside Cancer
WebMD Education – The Link Between Stroke and Atrial Fibrillation
WebMD Education – High Potassium: Causes and Reasons to Treat
Leiden University Medical Center, Netherlands – Anatomy of the Abdomen and Pelvis
MIT (Massachusetts Institute of Technology) – A Clinical Approach to the Human Brain
LeanMachine has now examined thousands of studies, journals and reports related to health and nutrition and this research is ongoing.

Updated 9th January 2020, Copyright © 1999-2020 Brenton Wight and BJ & HJ Wight trading as Lean Machine abn 55293601287

Glutathione and NAC Play Crucial Roles in Health and Fitness


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2019/12/30/glutathione-nac-for-health-and-fitness.aspx

Analysis by Dr. Joseph Mercola Fact Checked image
glutathione nac for health and fitness

STORY AT-A-GLANCE

  • Sulfur is the third most abundant mineral in your body. Sulfur-containing amino acids increase your levels of glutathione and N-acetylcysteine (NAC), which play important roles in health and fitness
  • Glutathione metabolism influences the control of epigenetic mechanisms at several levels, including substrate availability, enzymatic activity for DNA methylation and the expression of microRNAs
  • NAC supplementation may be useful for the prevention of cardiovascular problems in older people by lowering oxidative stress and improving mitochondrial function
  • Glutathione deficiency can induce epigenetic changes in genes that regulate vitamin D metabolism in the liver, and research suggests glutathione supplementation could help reduce the risk of vitamin D deficiency in obese individuals
  • Glutathione and NAC also ameliorate exercise-induced stress and reduce muscle fatigue. Glutathione may also play a central role in chronic fatigue syndrome

As explained in “The Health Benefits of MSM,” sulfur is the third most abundant mineral in your body and plays important roles in a variety of bodily processes, including metabolism and detoxification, and for maintaining the proper shape and structure of proteins and enzymes.

Sulfur-containing amino acids increase your levels of glutathione and N-acetylcysteine (NAC), and these two play important roles in health and fitness.

Glutathione Basics

Glutathione comprises three amino acids: cysteine, glutamate and glycine. It’s commonly referred to as “the master antioxidant,” as it is your body’s most powerful antioxidant, and is found inside every cell in your body.

Antioxidants combat free radicals — highly reactive particles that bounce around the cell, damaging everything they touch. Most originate during the process of metabolism but they can also arise during exercise, and from exposure to toxins, irradiation and toxic metals.

Because free radicals are so destructive, cells have a network of defenses designed to neutralize them. This antioxidant network is composed of numerous components that include vitamins, minerals and special chemicals called thiols (glutathione and alpha-lipoic acid).

Glutathione differs from other antioxidants in that it is intracellular, and has the unique ability of maximizing the activity of all the other antioxidants, including (but not limited to) vitamins C and E, CoQ10 and alpha lipoic acid. It also removes toxins from your cells and protects you from the damaging effects of radiation, chemicals and environmental pollutants.

NAC Basics

NAC is a precursor to and rate-limiting nutrient for the formation of glutathione.1 Glutathione is poorly absorbed so, in many cases, it’s easier to raise your glutathione by taking NAC instead.

In emergency medicine, NAC is used as an antidote for acetaminophen toxicity resulting from an overdose.2 Mortality due to acetaminophen toxicity has been shown to be virtually eliminated when NAC is promptly administered.

It is believed the liver damage acetaminophen causes is largely due to the fact that it can deplete glutathione, which is secreted by your liver in response to toxic exposure.

On a side note, NAC supplementation can also help “pre-tox” your body when taken before alcohol, thereby minimizing the damage associated with alcohol consumption — a tidbit that may be useful to know in light of approaching New Year’s celebrations.

Taking NAC (at least 200 milligrams) 30 minutes before you drink can help lessen the alcohol’s toxic effects. Vitamin B6 may also help to lessen hangover symptoms.

While the most common use of NAC is for liver support, it’s also showing promise as a neuroprotectant.3 Scientists are currently investigating it as a treatment for Parkinson’s disease, which has been linked to glutathione deficiency in the substantia nigra, a region that houses dopamine neurons.4

Research looking at autopsied brains suggests Parkinson’s patients have barely detectable levels of glutathione in this brain region. Subsequent studies have found glutathione deficiency in the substantia nigra is common in a number of other neurodegenerative conditions as well, including Alzheimer’s disease.5

Another area where NAC shows particular promise is in the treatment of mental health disorders, including post-traumatic stress disorder,6 depression7 and substance use disorders.8 Dozens of additional health benefits are also reviewed in a November 29, 2019, SelfHacked article.9

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Glutathione Helps Regulate Epigenetic Disease Mechanisms

One factor that can help explain the wide-ranging benefits of NAC and glutathione is glutathione’s role in the regulation of epigenetic disease mechanisms.10 As noted in a November 2017 paper in Free Radical Biology and Medicine:11

“Epigenetics is a rapidly growing field that studies gene expression modifications not involving changes in the DNA sequence.

Histone H3, one of the basic proteins in the nucleosomes that make up chromatin, is S-glutathionylated in mammalian cells and tissues, making Gamma-L-glutamyl-L-cysteinylglycine, glutathione (GSH), a physiological antioxidant and second messenger in cells, a new post-translational modifier of the histone code that alters the structure of the nucleosome.

However, the role of GSH in the epigenetic mechanisms likely goes beyond a mere structural function. Evidence supports the hypothesis that there is a link between GSH metabolism and the control of epigenetic mechanisms at different levels (i.e., substrate availability, enzymatic activity for DNA methylation, changes in the expression of microRNAs, and participation in the histone code).”

The following graphic12 illustrates how glutathione influences pathological changes in gene expression.

glutathione influences pathological changes in gene expression

NAC Improves Cardiovascular and Mitochondrial Function

According to a 2018 study,13 NAC supplementation may be useful for the prevention of cardiovascular problems in older people. As you might expect, oxidative stress can over time induce metabolic and functional changes that speed cardiovascular aging and dysfunction, and your glutathione levels declines with age, putting you at greater risk.

In this study, aging mice received either NAC or a combination of NAC and glycine. After seven weeks, their cardiac function was assessed, showing those receiving NAC plus glycine had improved several parameters of their cardiovascular function, including:

  • Improved diastolic function
  • Increased peak early filling velocity
  • Reduced relaxation time
  • Reduced left atrial volume
  • Reduced left ventricle end diastolic pressure

NAC alone did not impart these cardiovascular benefits, although both groups had decreased levels of inflammatory mediators. The NAC and glycine combination also improved mitochondrial function and upregulated mitochondrial genes in the heart that are normally downregulated with age.

According to the authors, “Our data indicate that NAC+Gly supplementation can improve diastolic function in the old mouse and may have potential to prevent important morbidities for older people.”

Glutathione Deficiency Lowers Vitamin D Levels in the Obese

Other recent research14 published in Scientific Reports shows that glutathione deficiency can induce epigenetic changes in genes that regulate vitamin D metabolism in the liver. Emerging evidence also suggests glutathione metabolism plays a role in the epigenetic regulation of oxidation-reduction (redox) reactions, the authors note.

According to this paper,15 obesity has been correlated with low levels of glutathione and 25-hydroxyvitamin D3 — especially in Type 2 diabetics and the obese16 — and when obese mice were fed a glutathione-deficient diet, it downregulated vitamin D metabolism genes and vitamin D receptors in the liver. As a result, oxidative stress increased.

According to the authors, their findings suggest glutathione supplementation could help reduce the risk of vitamin D deficiency in obese individuals. Supplementation with L-cysteine, a rate-limiting precursor to glutathione, has also been shown to increase vitamin D levels and reduce oxidative stress, the paper notes, which supports the link between glutathione and vitamin D.

Glutathione and NAC Ameliorate Exercise-Induced Stress

As mentioned earlier, exercise is one of the ways through which free radical production increases and, with it, oxidative stress. Provided you get enough rest between bouts, this oxidative stress is actually part of what makes exercise so beneficial.

That said, as noted in a 2005 paper,17 “Effective regulation of the cellular balance between oxidation and antioxidation is important when considering cellular function and DNA integrity as well as the signal transduction of gene expression.” In other words, excessive exercise can cause more harm than good. As explained by the authors:18

Exercise enthusiasts and researchers have become interested in recent years to identify any means to help minimize the detrimental effects of oxidative stress that are commonly associated with intense and unaccustomed exercise. It is possible that a decrease in the amount of oxidative stress a cell is exposed to could increase health and performance …

To protect against the deleterious effects of ROS [reactive oxygen species], our bodies have a complex system of endogenous antioxidant protection in the form of enzymes such as superoxide dismutase, catalase, and glutathione peroxidase. Under normal, resting conditions reactive oxygen species are removed from the cell preventing any subsequent damage.

However, under more extreme conditions such as: 1) inadequate intake of foodstuffs containing the antioxidants, 2) excessive intake of pro-oxidants, 3) exposure to noxious chemicals or ultraviolet light, 4) injury/wounds, and/or 5) intense exercise, especially eccentric exercise, the body’s endogenous antioxidant system is not able to effectively remove excessive ROS production.

In situations such as the ones listed above in which the production of pro-oxidant molecules increase to a point where the antioxidant system cannot effectively remove them is when oxidative stress is known to occur.

Oxidative stress has been implicated in a number of diseases which include atherosclerosis, pulmonary fibrosis, cancer, Parkinson’s disease, multiple sclerosis, and aging. Research on oxidative stress during exercise has begun to indicate that regular training enhances the ability of these mechanisms to effective respond to the increase of oxidative product.”

Exercise Boosts Your Glutathione Level

The 2005 paper above goes on to explain how exercise affects your glutathione level, and thus your health, fitness and risk of disease. In short, when you engage in intense exercise, your blood level of glutathione significantly decreases while circulating levels of oxidized glutathione increases, indicating that it’s been used inside the muscle to quench free radicals produced during the exertion.19

Considering the importance of glutathione to counteract free radicals, effective regulation of glutathione levels when exercising is a significant concern. The good news is that the more you exercise, the higher your base levels of glutathione get.

This adaptation allows your body to effectively deal with the increase in free radicals that the exercise brings about. While exercise itself will boost your glutathione level over time, raising glutathione through supplementation is an oft-used strategy among athletes.

As mentioned, glutathione supplementation is ineffective due to its poor absorption, so NAC is generally considered a much better choice. According to the authors of the 2005 paper cited above:20

“In addition to the role glutathione and other thiols have on maintaining the cellular redox state, many studies have begun to explore if NAC supplementation can actually improve performance due to its ability to promote a more favorable cellular environment to achieve higher levels of performance …

One of the first studies to utilize NAC to determine its role in improving muscle performance was conducted by Reid and colleagues. They pretreated subjects with n-acetyl-cysteine infusion (150 mg/kg) or a 5% dextrose placebo while undergoing an extended fatiguing bout of electrical stimulation of the ankle dorsiflexors.

N-acetyl-cysteine was found to have no impact over the nonfatigued muscle, but a significantly increased force output of approximately 15% was found after 3 minutes of repetitive contractions which persisted throughout the 30-minute protocol. The authors concluded that NAC resulted in improved performance suggestive of oxidative stress having a causal role in the fatigue process.”

Other studies have also confirmed that NAC supplementation helps delay muscle fatigue during exercise, thereby improving endurance. In one study,21 NAC infusion increased the time to exhaustion by 26.3%.

NAC’s ability to reduce fatigue and improve cellular redox (oxidation reduction) also hints at its potential benefit for those struggling with chronic fatigue syndrome (CFS).

The Glutathione Depletion Theory of CFS

As explained by the U.S. Centers for Disease Control and Prevention, CFS, also known as myalgic encephalomyelitis or ME, is characterized by “overwhelming fatigue that is not improved by rest.”22 The fatigue is frequently such that it challenges your ability to perform even the most common of daily life tasks, such as showering or preparing a meal.

The role of glutathione in this condition is addressed in “A Simple Explanation of the Glutathione/Methylation Depletion Theory of ME/CFS”23 by the late Rich Van Konynenburg, Ph.D., developer of the methylation protocol used by many in the CFS community.24,25

According to Van Konynenburg, oxidative stress “is probably the best-proven biochemical aspect of chronic fatigue syndrome,” and in order for your oxidative stress to overwhelm your system, something must be placing excessive demands on your glutathione supply.

Several examples were already listed above, such as inadequate antioxidant and/or excessive pro-oxidant intake, toxic exposures and physical injuries. Long-term emotional stress can also be a factor. As noted in Van Konynenburg’s article:

“All people experience a variety of stressors all the time, and a healthy person’s body is able to keep up with the demands for glutathione by recycling used glutathione molecules and by making new ones as needed.

However, if a person’s body cannot keep up, either because of extra-high demands or inherited genetic polymorphisms that interfere with recycling or making glutathione, or both, the levels of glutathione in the cells can go too low …

One of the jobs that glutathione normally does is to protect your supply of vitamin B12 from reacting with toxins … When your glutathione level goes too low, your B12 becomes naked and vulnerable, and is hijacked by toxins.

Also, the levels of toxins rise in the body when there isn’t enough glutathione to take them out, so there are two unfortunate things that work together to sabotage your B12 when glutathione goes too low.”

The B12-Glutathione Connection

Vitamin B12 helps your body convert food into glucose for energy, and fatigue is one of the symptoms of low B12 levels.26 Interestingly, many with CFS have elevated B12 levels. Their bodies simply cannot use it properly, and one potential culprit is low glutathione.

“The best test to reveal this is a urine organic acids test that includes methylmalonic acid. It will be high if the B12 is being sidetracked, and this is commonly seen in people with CFS,” Van Konynenburg states, adding:27

“The most important job that B12 has in the body is to form methylcobalamin, which is one of the two active forms of B12. This form is needed by the enzyme methionine synthase, to do its job. An enzyme is a substance that catalyzes, or encourages, a certain biochemical reaction.

When there isn’t enough methylcobalamin, methionine synthase has to slow down its reaction. Its reaction lies at the junction of the methylation cycle and the folate cycle, so when this reaction slows down, it affects both these cycles …

The methylation cycle has some important jobs to do. First, it acts as a little factory to supply methyl (CH3) groups to a large number of reactions in the body. Some of these reactions make things like creatine, carnitine, coenzyme Q10, phosphatidylcholine, melatonin, and lots of other important substances for the body.

It is not a coincidence that these substances are found to be low in CFS … Not enough of them is being made because of the partial block in the methylation cycle.

The methylation cycle also supplies methyl groups to be attached to DNA molecules, and this helps to determine whether the blueprints in the DNA will be used to make certain proteins according to their patterns.

The ‘reading’ of DNA is referred to as ‘gene expression.’ Methyl groups prevent or ‘silence’ gene expression. Overexpression of genes has been observed in CFS patients, and I suspect this is at least partly due to lack of sufficient methylation to silence gene expression.”

The Basic Biochemical Mechanism of CFS

The methylation cycle also regulates your body’s use of sulfur, and the production of sulfur-containing substances, including glutathione. CFS patients often have abnormal levels of sulfur metabolites. Once you understand the interconnectedness of glutathione, B12 and the methylation cycle, it becomes easier to see how chronic CFS arises. As explained by Van Konynenburg:28

“When glutathione goes too low, the effect on vitamin B12 slows down the methylation cycle too much. The sulfur metabolites are then dumped into the transsulfuration pathway (which is connected to the methylation cycle) too much, are oxidized to form cystine, pass through hydrogen sulfide, and are eventually converted to thiosulfate and sulfate and are excreted in the urine.

This lowers the production of glutathione, which requires cysteine rather than cystine, and now there is a vicious circle mechanism that preserves this malfunction and keeps you sick … That’s the basic biochemical mechanism of CFS … everything else flows from this …

Here’s how I believe the fatigue occurs: The cells have little powerplants in them, called mitochondria. Their job is to use food as fuel to produce ATP (adenosine triphosphate). ATP acts as a source of energy to drive a very large number of reactions in the cells.

For examples, it drives the contraction of the muscle fibers, and it provides the energy to send nerve impulses. It also supplies the energy to make stomach acid and digestive enzymes to digest our food, and many, many other things.

When glutathione goes too low in the muscle cells, the levels of oxidizing free radicals rise, and these react with parts of the ‘machinery’ in the little powerplants, lowering their output of ATP.

So the muscle cells then experience an energy crisis, and that’s what causes the fatigue. Over time, because of the lack of enough glutathione, more problems accumulate in the mitochondria, including toxins, viral DNA, and mineral imbalances.”

All of these factors will ultimately decimate your immune function as well, allowing pathogenic bacteria, viruses and fungi to take over. CFS patients will frequently have several infections ongoing at the same time. Low glutathione also impedes your body’s natural detoxification pathways, allowing toxicity to build over time, thereby causing ever-increasing dysfunction.

The Answer for CFS

So, how do you turn this chain of events around? As noted in Van Konynenburg’s article:29

“The main key to turning this process around is to help the methionine synthase enzyme to operate more normally, so that the partial block in the methylation cycle and the folate cycle are lifted, and glutathione is brought back up to normal. That is what the simplified treatment approach is designed to do, and so far, the evidence is that it does do these things in most people who have CFS.

I recommend that people with CFS have the Vitamin Diagnostics methylation pathways panel run to find out if they do in fact have a partial methylation cycle block and glutathione depletion before deciding, with their doctors, whether to try this treatment.

This also provides a baseline so that progress can be judged later on by repeating it every few months during the treatment. Symptoms may not be a good guide to judge progress during treatment, because detoxing and die-off can make the symptoms worse, while in fact they are exactly what is needed to move the person toward recovery.”

An outline of Van Konynenburg’s simplified methylation treatment plan for CFS can be found in HealthRising.org.30 At the core of this treatment is the use of specific supplements, including folate, B12, a multivitamin, SAMe and phosphatidyl serine.

In his protocol, he explains the theory behind the use of each of these supplements, how they impact the methylation cycle, and their interactions with other supplements.

My take-home message here is that glutathione and NAC supplementation may not always be the ideal way to go. People with CFS may be better supported by a customized assessment by an experienced clinician that may also include methyl folate and methyl vitamin B12.

General Dosing and Safety Guidelines for NAC

For many others, however, NAC can be safely used to boost glutathione levels. For more information about how NAC can benefit your health, see “The Many Benefits of NAC.” It’s widely available as an oral dietary supplement and is relatively inexpensive. Unfortunately, like glutathione, NAC is poorly absorbed when taken orally, although it’s better than glutathione.

According to some studies,31,32 NAC’s oral bioavailability may range between 4% and 10%, which is why the recommended dosage can go as high as 1,800 milligrams (mg) per day. Its half-life is also in the neighborhood of two hours, which is why most study subjects take it two or three times a day.

No maximum safe dose has yet been determined, but as a general rule, it’s well-tolerated, although some do experience gastrointestinal side effects such as nausea, diarrhea or constipation. Should this occur, reduce your dosage. It’s also best taken in combination with food, to reduce the likelihood of gastrointestinal effects.

Also keep in mind that since NAC boosts glutathione, which is a powerful detox agent, you may experience debilitating detox symptoms if you start with too high a dose. To avoid this, start low, with say 400 to 600 mg once a day, and work your way up.

Also, if you are currently taking an antidepressant or undergoing cancer treatment, be sure to discuss the use of NAC with your physician, as it may interact with some antidepressants and chemotherapy.

 Sources and References

Does Vitamin D Supplementation Prevent Cancer and Cardiovascular Disease?


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2019/12/17/vitamin-d-supplements-disease-prevention.aspx

Analysis by Dr. Joseph MercolaFact Checked
vitamin d supplements disease prevention

STORY AT-A-GLANCE

  • Recent research claims “high dose” vitamin D supplementation did not result in a lower incidence of cancer or cardiovascular events than placebo
  • The “high dose” given in this trial was a mere 2,000 international units (IUs) a day, which is still only a quarter or less of what many need to raise their blood level into a protective range
  • The study did not test and track participants’ vitamin D blood levels, which is the only way to ensure sufficiency and adherence to the protocol
  • Cancer is a slow-growing disease and effects of nutritional intervention typically only become evident after several years. When the first two years of follow-up data were excluded, people who took 2,000 IUs of vitamin D3 per day had a 25 percent lower risk of cancer in the years following (years three through five)
  • Many need upward of 10,000 IUs a day in order to achieve a blood level of 40 ng/mL (100 nmol/L) or higher, which is the bottom cutoff for health and disease prevention. Ideally, you’ll want a level between 60 and 80 ng/mL (150 and 200 nmol/L)

The effectiveness of vitamin D supplementation has again been questioned with negative headlines1,2 trumpeting its failure to prevent cancer and cardiovascular disease. What most researchers and journalists fail to address, however, is the fact that:

  • The “high dose” given in this trial was a mere 2,000 international units (IUs) a day, which is still only a quarter or less of what many need to raise their blood level into a protective range
  • They did not test and track participants’ vitamin D blood levels, which is the only way to ensure sufficiency

Based on those two factors alone, a negative result is precisely what one would predict. Still, despite such limitations, the study actually found some rather remarkable benefits that were simply glossed over.

In fact, had it been a drug trial, vitamin D would likely have been declared a miracle drug against both cancer and cardiovascular disease, based on the findings. This is the kind of perversion of science and selective reporting that shackles public health.

VITAL Study Conclusions

The study3,4 in question, which was in part funded by the U.S. National Institutes of Health, was published in the January 2019 issue of the New England Journal of Medicine (NEJM). (A second study5 compared omega-3 supplementation against placebo for the same endpoints.) As detailed in the vitamin D paper, the study was:

“[A] nationwide, randomized, placebo-controlled trial, with a two-by-two factorial design, of vitamin D3 (cholecalciferol) at a dose of 2000 IU per day6 and marine n−3 (also called omega-3) fatty acids at a dose of 1 gram per day7 for the prevention of cancer and cardiovascular disease among men 50 years of age or older and women 55 years of age or older in the United States.

Primary end points were invasive cancer of any type and major cardiovascular events (a composite of myocardial infarction, stroke or death from cardiovascular causes). Secondary end points included site-specific cancers, death from cancer and additional cardiovascular events.”

In conclusion, the authors determined that “Supplementation with vitamin D did not result in a lower incidence of invasive cancer or cardiovascular events than placebo.”

What the VITAL Data Actually Reveals

However, as noted by GrassrootsHealth,8 a nonprofit public health research organization dedicated to moving public health messages regarding vitamin D and omega-3 from research into practice, “when the separate types of heart disease or death from cancer were analyzed, there were 30 different very significant results,” summarized in the graph9 below.

risk reduction vitamin d omega-3

Importantly, when the researchers excluded data from the first two years of supplementation, cancer mortality “was significantly lower with vitamin D than with placebo.”10 The reason this is important is because cancer is a slow-growing disease and effects of nutritional intervention typically only become evident after several years. It’s unreasonable to think you can take a supplement and within weeks or months see a drastic difference in health outcomes. The paper states that clearly, and adds:

“Supplemental vitamin D also did not reduce the occurrence of breast, prostate or colorectal cancers. However, there was a suggestive 17 percent reduction in cancer deaths, which became a 25 percent reduction in analyses that excluded the first two years of follow-up.”

Let me repeat those two points for clarity:

  1. While incidence of breast, prostate and colorectal cancers were unaffected, those who took a non-ideal dose of vitamin D3 supplements still had a 17 percent lower risk of actually dying from those cancers
  2. When the first two years of follow-up data were excluded, people who took a mere 2,000 IUs of vitamin D3 per day had a 25 percent lower risk of cancer in the years following (years three through five)

How is this not good news? Again, let’s remember that 2,000 IUs is really insufficient for most people, yet even at this insufficient dosage, the risk of cancer was cut by 25 percent.

For Most, 2,000 IUs a Day Is Suboptimal for Cancer Prevention

In years past, it was widely believed that 4,000 IUs was the upper safe limit, above which you risked vitamin D toxicity, but studies have since refuted this, showing there’s no risk of toxicity until you hit 30,000 IUs a day, or a blood level of 200 ng/ml (500 nmol/L).11 Still, the misconception persists.

A significant body of research shows many need upward of 10,000 IUs a day in order to achieve a blood level of 40 ng/mL (100 nmol/L) or higher, which is the bottom cutoff for health and disease prevention. Ideally, you’ll want a level between 60 and 80 ng/mL (150 and 200 nmol/L). This is where the majority of health benefits become really apparent.

As noted in a 2009 study12 on athletic performance and vitamin D, “At levels below 40 to 50 ng/mL the body diverts most or all of the ingested or sun-derived vitamin D to immediate metabolic needs, signifying chronic substrate starvation (deficiency).”

As noted earlier, the VITAL study did not use vitamin D blood levels as the marker for deficiency or sufficiency, and this is perhaps the most significant problem with this study. Blood levels were only measured in a subgroup of 1,644 participants (out of 25,871) after the first year of daily supplementation.

In this group, the mean vitamin D blood level increased from 29.8 ng/mL (74 nmol/L) at baseline to 41.8 ng/mL (104 nmol/L). In other words, most of those taking vitamin D supplements had barely adequate vitamin D levels, and were still significantly short of having ideal blood levels — levels at which research shows the risk of cancer is cut up to 80 percent.

Why You Cannot Trust Studies That Base Results on Dosage Rather Than Blood Measurement

This certainly is not the first time studies have claimed vitamin D supplementation is useless. Last year, a meta-analysis13 concluded once-a-month high-dose vitamin D supplementation had no impact on cancer risk. Here, participants received an initial bolus dose of 200,000 IUs of vitamin D, followed by a monthly dose of 100,000 IUs (so-called pulsed or pulsatile dosing) for a median of three years.

While the media played this up as a finding contradicting recommendations to optimize your vitamin D to lower your cancer risk, it really only made a case against once-a-month mega-dosing. As noted by GrassrootsHealth scientists, for optimal results, you need to supplement frequently (ideally daily) and focus on the achieved serum level, not the dosage.

What’s more, 100,000 IUs per month actually only comes out to about 3,000 IUs per day, which again is far below what most adults need to raise their vitamin D serum level into the protective range of 60 to 80 ng/mL, with 40 ng/mL being the low-end cutoff for sufficiency.

Indeed, this analysis noted the mean baseline vitamin D concentration was just over 26 ng/mL, and the mean follow-up level was just 20 ng/mL higher in the supplement group than the placebo group that received no vitamin D.

As in the current NEJM study, participants’ vitamin D levels were also not measured regularly throughout the study, and the association with cancer was not analyzed by serum level but by daily dosage.

This point really cannot be stressed enough: The key factor is not how much vitamin D you take but whether or not your blood level of vitamin D is within the “Goldilocks’ zone” of 60 to 80 ng/mL, and the only way to ascertain that is through blood testing.

How to Assess Study Quality

GrassrootsHealth scientists have also argued that pulsatile dosing at intervals greater than two weeks may actually cause a form of vitamin D deficiency at the cellular level.

According to GrassrootsHealth, to accurately ascertain the benefit of vitamin D in any given trial, researchers must track not only the baseline and final vitamin D serum level plus the dose given, but also the form (vitamin D2 versus D3) and the dosing interval.

Adherence to protocol is also measured by blood level. If a participant’s blood level doesn’t change, you know that individual was probably not taking the supplement as instructed, rendering their result null and void.

All of these factors can influence the results, and it’s important to get them all right. Identifying the ideal parameters are all part of what GrassrootsHealth is doing. Another study, published in 2017, claimed it found “no case” for vitamin D supplementation during pregnancy.14

In reality, it found seven positive outcomes,15 including increased birth weight, a 40 percent reduction in gestational diabetes, an 18 percent reduction in preeclampsia and a 17 percent reduction in gestational hypertension.

What this study failed to find was a reduction in preterm birth, and this was ultimately translated into headlines that made it appear as though pregnant women have no need for vitamin D supplementation! In reality, nothing could be further from the truth.16,17

So, in summary, when evaluating vitamin D research, the following parameters are what you’re looking for in a high-quality study, as without these, the results are likely to be significantly flawed and likely negative:

Supplementation should be frequent, ideally daily — Bolus doses given at intervals greater than two weeks are likely to be ineffective. According to Carole Baggerly, director and founder of GrassrootsHealth, pulsatile dosing at intervals greater than two weeks may actually cause a form of vitamin D deficiency at the cellular level.

Dosage, baseline and final vitamin D serum level must all be tracked — Most studies fail in this regard, as most only track dosage and not serum level, which is the most crucial parameter of all.

In short, it doesn’t matter how large or small the dose is, as long as it gets the participants into a specific blood level range, as the individual response to any given dose varies widely, depending on several different factors, including intake of other nutrients (such as magnesium), age, ethnicity, body weight and amount of sun exposure.

The form of vitamin D must be identified — Are they using vitamin D2 or D3? And are they tracking sun exposure, which is the primary way your body produces vitamin D?

There’s Strong Evidence Vitamin D Lowers Your Chronic Disease Risk

Vitamin D, a steroid hormone, is vital for the prevention of many chronic diseases, including but not limited to:

  • Type 2 diabetes
  • Age-related macular degeneration (the leading cause of blindness)
  • Alzheimer’s disease
  • Heart disease
  • Well over a dozen different types of cancer, including skin cancer — the very cause of concern that has led so many to avoid the sun exposure necessary for vitamin D production

In the case of heart disease, vitamin D plays a vital role in protecting and repairing damage to your endothelium.18 It also helps trigger production of nitric oxide — which improves blood flow and prevents blood clot formation — and significantly reduces oxidative stress in your vascular system, all of which are important to help prevent the development and/or progression of cardiovascular disease.

Just last year, a Norwegian study19 published in The Journal of Clinical Endocrinology and Metabolism found “a normal intake of vitamin D” significantly reduces your risk of death if you have cardiovascular disease.20

According to vitamin D researcher Dr. Michael Holick, vitamin D deficiency — defined as a level below 20 ng/mL (50 nmol/L) — can also raise your risk of heart attack by 50 percent, and if you have a heart attack while vitamin D deficient, your risk of dying is nearly guaranteed.

Vitamin D also has powerful infection-fighting abilities, making it a useful aid in the treatment of tuberculosis, pneumoniacolds and flu, while maintaining a healthy vitamin D level will typically prevent such infections from taking root in the first place. Studies have also linked higher vitamin D levels with lowered mortality from all causes.21,22,23

A Majority of Breast Cancer Cases Could Be Avoided by Raising Vitamin D Levels Among the General Public

Importantly, the ongoing research by GrassrootsHealth has firmly established that 20 ng/mL, which is conventionally considered the cutoff for sufficiency, is nowhere near sufficient for optimal health and disease prevention.

As mentioned, 40 ng/mL (100 nm/L) appears to be at the low end of optimal, and most participants in the featured NEJM study were likely hovering right around this low-end blood level (based on measurements from a very limited subgroup).

Still, recall the risk of cancer in Years 3 through 5 among those who supplemented with 2,000 IUs a day (thereby reaching a mean blood level of just under 42 ng/mL) went down by 25 percent. GrassrootsHealth research shows the ideal protective range is between 60 and 80 ng/mL (150 to 200 nm/L), and the higher the better within this range.

Research has actually demonstrated that most cancers occur in people with a vitamin D blood level between 10 and 40 ng/mL.24,25 Meanwhile, research shows women with vitamin D levels above 60 ng/mL have an 83 percent lower risk of breast cancer than those with levels below 20 ng/mL.26 Data from GrassrootsHealth ongoing D*Action study actually suggests 80 percent of breast cancer incidences could be prevented simply by optimizing vitamin D and nothing else!

breast cancer rates vitamin d level

The key, however, is to achieve the proper blood level, which has nothing to do with dosage. And the reason this correlation has never been elucidated before is because no one was using high-enough dosage to actually get participants vitamin D levels above 60 ng/mL, which is where you really start seeing these dramatic reductions in disease.

Optimizing Your Vitamin D Is a Key Disease Prevention Strategy

The evidence in support of vitamin D optimization is overwhelming, and becomes all the more compelling when the blood level is the primary parameter being measured and tracked. The key take-home message here is that 2,000 IUs is insufficient for most people, although it may still cut the risk of cancer by about 25 percent.

Overall, research supports the idea that higher levels offer greater cancer protection, and even levels as high as 100 ng/mL appear safe and beneficial. Importantly, having a serum vitamin D level of 60 ng/mL has been shown to positively impact anyone with breast cancer or Type 1 diabetes, as well as pregnant women and lactating mothers.

It’s a shame that so many researchers still have not grasped the importance of measuring blood levels rather than simply going by dosage, and relatively low dosages at that. In reality, what this NEJM study (and others like it) show is that insufficient vitamin D dosage fails to achieve optimal results. It’s not that vitamin D itself is useless. GrassrootsHealth D*Action study is clearly leading the pack here, revealing what’s required.

It’s an ongoing study that relies on public participation, and you can join at any time. To participate, simply purchase the D*Action Measurement Kit and follow the registration instructions included. (Please note that 100 percent of the proceeds from the kits go to fund the research project. I do not charge a single dime as a distributor of the test kits.)

As a participant, you agree to test your vitamin D levels twice a year during a five-year study, and share your health status to demonstrate the public health impact of this nutrient. There is a $65 fee every six months for your sponsorship of this research project, which includes a test kit to be used at home, and electronic reports on your ongoing progress.

You will get a follow up email every six months reminding you “it’s time for your next test and health survey.” By participating in this project, you help move vitamin D research forward so that, hopefully, one day we can end this nonsensical debate about whether vitamin D optimization is worth pursuing or not.

– Sources and References

The cancer fighting benefits of Coenzyme Q10

Reproduced from original article:
www.naturalhealth365.com/benefits-of-coq10-3221.html

by:  

benefits-of-coq10

(NaturalHealth365) Coenzyme Q10, or CoQ10, is a substance found in every cell of our body. It is in a variety of foods, and healthy people are not likely to develop a deficiency of this nutrient. But, you might want to think about taking in some extra CoQ10 – especially if you’re taking a statin to lower your cholesterol levels.

CoQ10 has many potential health benefits, including possibly lowering the risk of certain cancers. Women, especially, should take note, since recent research points to links between breast cancer risk and lower levels of CoQ10 in the blood.

Clearing up the confusion about CoQ10

Coenzyme Q10 is technically not a vitamin because your body can synthesize it, so you do not need to get it from food. However, its structure is similar to that of vitamins. Also like vitamins, it acts as a coenzyme functions in your body’s metabolic reactions.

CoQ10 also has powerful antioxidant properties. For example, it helps prevent harmful oxidation of LDL cholesterol, and it supplements the work of vitamin E, or tocopherol. When your blood levels of CoQ10 are lower, your body needs more vitamin E from the diet to carry out heart-healthy antioxidant reactions.

What are the health benefits associated with CoQ10?

Can a Coenzyme Q10 deficiency increase the risk of cancer?

Since the 1960s, researchers have noted associations between lower blood levels of CoQ10 and cancer. People with lymphoma, myeloma, and lung, head, neck, and prostate cancers tend to have lower levels of CoQ10.

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A recent study looking into links between CoQ10 and breast cancer examined data from nearly 1,000 women aged 40 to 70 in the Shanghai Women’s Health Study. Those who had serum levels of CoQ10 in the bottom fifth of participants had a 90 percent greater chance of being diagnosed with breast cancer than those whose levels were in the middle fifth.

“The current Shanghai Women’s Health Study, with relatively larger sample size and longer follow-up time suggests an inverse association for plasma CoQ10 levels with breast cancer risk in Chinese women,” according to study authors Robert V. Cooney of the University of Hawaii and colleagues. Based on these results, future research should investigate potential effects of supplementation on the risk of breast cancer.

The study also confirmed the association between low CoQ10 and higher risk of cervical cancer, myeloma, and melanoma. This makes the results relevant to men as well as women. This study is far from definitive, but it seems likely that there is a link between healthy CoQ10 levels and reduction in cancer risk.

CoQ10 is in a variety of foods, including meat, fish, and eggs, and organ meats, such as heart, kidney, and liver, are especially rich sources. You can also find CoQ10 in plant-based foods, such as cauliflower, peanuts, soybean oil, and strawberries.

Obviously, you can obtain additional benefits, with ease, by supplementing your diet with a high quality CoQ10 supplement.

Sources for this article include:

Healthline.com
NaturalHealth365.com

Warfarin – The Rat Poison Drug

Written by Brenton Wight – LeanMachine, Health Researcher
Posted 8th December 2017, Updated 4th December 2019.
Copyright © 1999-2019 Brenton Wight and BJ&HJ Wight trading as Lean Machine abn 55293601285

Why use Warfarin?

Warfarin is a blood thinner, belonging to a class of drugs known as anti-coagulants, designed to keep blood thin and prevent clots. They make it hard for clots to form, which is a good thing if we are trying to prevent an ischemic (blood blockage) stroke, but a bad thing if we have a hemorrhagic (bleeding)stroke.
It is the most often prescribed drug prescribed for AF (atrial fibrillation), a type of irregular heartbeat, where upper chambers of the heart quiver instead of contracting efficiently, affecting millions of people.
Although AF is not necessarily life-threatening by itself, it can increase risk of blood clots which can break free to cause an ischemic stroke if the clot lodges in a brain artery, or pulmonary thrombosis if lodged in a lung artery.
However, there are down sides.
– Warfarin makes it difficult to stop a cut from bleeding.
– Warfarin increases risk of a hemmorhagic stroke (bleeding in the brain).
– Warfarin increases risk of intestinal bleeding.
– Warfarin increases risk of an aneurysm where a blood vessel ruptures.
– Warfarin increases risk of uncontrolled bleeding due to a fall or accident.

The Warfarin Study

A new study shows that Warfarin (marketed under the name Coudamin), a heart drug taken by millions of people, increases dementia risk 300%.
This study, led by Dr. T. Jared Bunch, was conducted by the Intermountain Healthcare Clinical Pharmacist Anticoagulation Service, based in Salt Lake City, and examined the medical records of more than 10,000 patients.
Dr Bunch presented the study results at the Heart Rhythm Society’s annual meeting in San Francisco.
The findings were:

  • Patients with erratic warfarin levels have a higher risk of small clots, or small bleeds in the brain, causing dementia
  • AF patients have three times the risk of dementia compared to those who take warfarin for other conditions
  • Some foods, drinks, antibiotics and other drugs alter warfarin blood levels quickly. Regular blood tests and dose variations are essential to maintain the correct range
  • The dementia risk increases to four times higher if the dose is not exactly right or requires frequent adjustment

History of Rat Poison

The University of Wisconsin developed the drug as a rat poison in the 1940’s. It kills rodents by invoking bleeding. Rats bleed to death after ingesting the poison.
Endo Laboratories began selling it for human use in the 1950’s, but Warfarin proved to be a management problem for doctors and patients. Bad reactions to many foods and some drugs, especially antibiotics, are common with Warfarin treatment.

Warfarin Side Effects

Another study by New England Journal of Medicine showed that warfarin accounts for double the emergency hospitalizations than any other drug, and is the leading cause of emergency room visits by seniors.
Apart from dementia, warfarin causes internal bleeding, stomach ulcers, kidney failure, and chronic cough. Hillary Clinton takes warfarin, and has suffered a severe cough while campaigning in 2016.
Of course, given that dementia is a common problem with seniors, and the risk for dementia is three to four times higher, more dementia means more missed or doubled-up doses of Warfarin, sometimes leading to death of the patient.

Prescription Alternatives

There are a few options:

  • Apixaban (Eliquis)
  • Dabigatran (Pradaxa)
  • Edoxaban (Savaysa)
  • Rivaroxaban (Xarelto)

Whichever we use, there is always a risk of bleeding problems.
The new medications have a reduced risk of bleeding, and wear off faster than warfarin, so appear to be safer.
However, dangerous bleeding while taking warfarin can be controlled with Vitamin K, or a combination of PCC (prothrombin complex concentrate) and fresh frozen plasma.
The amount of vitamin K in the diet, contained in leafy green vegetables, determines the effectiveness of Warfarin, so we must consistently eat the same foods. We can eat salads (and we should) but we have to eat them all the time with warfarin. This is not a problem for the new drugs because Vitamin K does not interfere with their operation. If we ate plenty of salads regularly throughout our life, we would probably never need warfarin!
Praxbind (idarucizumab) can be used in emergencies to reverse the anti-clotting effects of Pradaxa.
Other drugs to reverse blood-thinning are still in development.
Xarelto currently (in 2019) has no approved antidote, meaning that an overdose or a bleed from, say, a fall resulting in a nasty bump on the head, could cause death by a brain bleed.
Because Xarelto and others have no really effective antidote, bleeding is difficult to control. Given that many seniors with poor cognitive function are taking these drugs, overdosing is common, and can cause death. A horrifying sight in the emergency room is a patient bleeding from the nose, eyes, fingernails, toenails etc.

Drugs and Lifestyle

The new drugs are more convenient in that they do not require as many blood tests as warfarin, which requires testing at least monthly, after getting the initial dose right, where the starting dose is high, followed by a maintenance dose, and blood tests are required every 2 to 3 days until the levels stabilise.
Apart from the inconvenience of regular blood testing, many people do not like getting stuck with a needle so often.

Interaction with Other Medications

Some prescription drugs, some supplements and some foods interfere with warfarin, while others make warfarin work too well, which can cause a major bleeding problem.
Some seniors have presented at the emergency room with blood coming from all fingernails, toenails, eyes, nose, mouth, etc.
Often the slightest bump in the body results in extensive bruising, and a small cut results in excessive bleeding.
There is an enormous list of medications that interact with warfarin. The newer blood thinners also have interactions, but nowhere near as many.
The new blood thinners have some benefits over warfarin, but if we manage our warfarin well, there is no need to change. However, if we have kidney failure or mechanical heart valves the new medications may not be safe.

Natural Alternatives

Warfarin patients whose dosages often change should ask their doctor for alternative medications, as other blood thinners have fewer potential problems.
Aspirin is another blood-thinning medication given to those with cardiovascular problems, but again, can cause massive problems with internal bleeding, loss of eyesight from Macular Degeneration (bleeding and expansion of blood vessels in the retina), or hemmorhagic stroke (brain bleed).
Natural remedies work well for some people, and here are a few known to work:

These or other natural alternatives may require Warfarin levels to be lowered. Thinning the blood too much while taking Warfarin may be very dangerous.
Green leafy vegetables, high in vitamin K, act as an antidote to warfarin, requiring higher dosage for effectiveness, but a change in diet will cause a higher risk of bleeding.

LeanMachine online supplements

Disclaimer

LeanMachine is not a doctor, and everyone should consult with their own health professional before taking any product to ensure there is no conflict with existing prescription medication.
LeanMachine has been researching nutrition and health since 2011 and has completed many relevant studies including:
Open2Study, Australia – Food, Nutrition and Your Health
RMIT University, Australia – Foundations of Psychology
Swinburne University of Technology, Australia – Chemistry – Building Blocks of the World
University of Washington, USA – Energy, Diet and Weight
Johns Hopkins Bloomberg School of Public Health, USA – Health Issues for Aging Populations
Johns Hopkins Bloomberg School of Public Health, USA – International Nutrition
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics I
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics II
Johns Hopkins Bloomberg School of Public Health, USA – Principles of Human Nutrition
TUFTS University, USA – Nutrition and Medicine
TUFTS University, USA – Lipids/Cardiovascular Disease I and Lipids/Cardiovascular Disease II
Technical Learning College, USA – Western Herbology, Identification, Formulas
Bath University, England – Inside Cancer
WebMD Education – The Link Between Stroke and Atrial Fibrillation
WebMD Education – High Potassium: Causes and Reasons to Treat
Leiden University Medical Center, Netherlands – Anatomy of the Abdomen and Pelvis
MIT (Massachusetts Institute of Technology) – A Clinical Approach to the Human Brain
LeanMachine has now examined thousands of studies, journals and reports related to health and nutrition and this research is ongoing.

Posted 8th December 2017, Updated 4th December 2019. Copyright © 1999-2019 Brenton Wight and BJ & HJ Wight trading as Lean Machine abn 55293601285