Alzheimer’s

now browsing by category

 

Excess Body Fat Can Age Your Brain Faster Than Muscle


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2020/01/09/obesity-and-brain-health.aspx
Analysis by Dr. Joseph Mercola Fact Checked image
January 09, 2020

excess body fat and brain health

STORY AT-A-GLANCE

  • Increasing research shows that maintaining healthy levels of body fat and greater muscle mass has an effect on your brain health and may slow your rate of cognitive aging
  • People with higher amounts of abdominal fat had worse fluid intelligence with age, while those with greater muscle mass were more protected against such declines
  • Women who had greater muscle mass tended to have better scores in fluid intelligence during the study period
  • Past research has linked midlife obesity with an increased risk of mild cognitive impairment, changes in short-term memory and executive functioning and dementia
  • In addition to regular exercise to increase muscle mass, eating a ketogenic diet to maintain a healthy body weight and avoid obesity may support your brain health as you age

Staying fit as you age is about far more than aesthetics. Increasing research shows that maintaining healthy levels of body fat and greater muscle mass has an effect on your brain health and even your rate of cognitive aging. It’s known, for instance, that being obese in midlife and early late-life is associated with worse cognitive aging.1

What’s more, the amount of muscle and fat you have may be a more important factor in how your level of fluid intelligence decreases over time than your chronological age. Your chronological age, i.e., your age in years, is just a numerical measurement, but your real age is your biological age as dictated by your choices and habits, as well as your modifiable risk factors like levels of muscle and fat.

While many people tend to gain fat and lose muscle mass as they age, this can be largely combated by staying active and eating right — lifestyle choices that will influence your cognitive function significantly.

More Muscle, Less Fat Protects Your Brain

In a study by Iowa State researchers, data from 4,431 adults were examined to compare levels of lean muscle mass, abdominal fat and subcutaneous fat with changes in fluid intelligence — the ability to solve problems in new situations — over a six-year period.2,3

Those with higher amounts of abdominal fat had worse fluid intelligence with age, while those with greater muscle mass were more protected against such declines. In fact, women who had greater muscle mass tended to have better scores in fluid intelligence during the study period.

Study co-author Auriel Willette, assistant professor of food science and human nutrition at Iowa State University, said in a news release, “Chronological age doesn’t seem to be a factor in fluid intelligence decreasing over time. It appears to be biological age, which here is the amount of fat and muscle.”4

What’s more, the study revealed a link between the immune system and how changes in fat levels affect cognition. Previous research suggests a higher body mass index (BMI) leads to greater immune system activity in the blood, which in turn activates the immune system in the brain, with a negative outcome on cognitive function.5

The featured study also found that changes in white blood cells called lymphocytes and eosinophils explained the link between abdominal fat and worsening fluid intelligence in women. In men, basophils, another type of white blood cell, were linked to about half of the link between fat levels and fluid intelligence, the study found.6

“Lymphocytes, eosinophils, and basophils may link adiposity to cognitive outcomes,” the researchers explained.7 Similar research has revealed that overweight and obese individual have greater brain atrophy in middle-age, corresponding with an increase in brain age of 10 years.8

How Obesity Affects Your Brain

Obesity has multiple effects on the brain, including anatomically speaking. Obese individuals may have reduced gray matter in brain regions such as the hippocampus, prefrontal cortex and other subcortical regions. Atrophy in the hippocampus, in turn, has been linked to Alzheimer’s disease.9

Gray matter is the outer layer of the brain associated with high-level brain functions such as problem-solving, language, memory, personality, planning and judgment. Even in elderly people who are otherwise cognitively normal, obesity is associated with measureable deficits in brain volume in the frontal lobes, anterior cingulate gyrus, hippocampus, and thalamus compared to individuals with a normal weight.10

Further research published in Radiology found that obesity may lead to alterations in brain structure, shrinking certain regions.11 Among men, higher total body fat percentage was linked to lower brain gray matter volume. Specifically, 5.5% greater total body fat percentage was associated with 3,162 mm3 lower gray matter volume.

Among men, 5.5% greater total body fat was also associated with 27 mm3 smaller globus pallidus volume, an association also seen in women. In women, 6.6% greater total body fat percentage was associated with 11.2 mm3 smaller globus pallidus volume.

The globus pallidus is a brain region that plays a role in supporting a range of functions, including motivation, cognition and action.12 Obesity was also associated with changes in white matter microstructure, which may be related to cognitive function.13

Cognitively speaking, there’s also a strong link between obesity and deterioration in cognitive function, as well as to other brain disorders such as dementia, anxiety and depression. Further, past research has linked midlife obesity with an increased risk of mild cognitive impairment, changes in short-term memory and executive functioning and dementia.14

Advertisement

Get my FREE 20 health resolutions for 2020 here


Obesity-Associated Health Problems Also Harm Your Brain

Obesity’s effects on brain health are also due to its associated health problems, including heart disease, diabetes and atherosclerosis, each of which can have its own deleterious effects on your brain. For instance, as noted in Frontiers in Neuroscience:15

“Obesity-derived vascular problems, such as atherosclerosis and arteriosclerosis, which are systemic diseases, are known to affect the steady blood flow of vessels that feed the brain, thus contributing to cognitive impairment or even stroke, where large areas of the brain die due to the stop in the blood flow of a major brain artery caused by a blood clot.”

In terms of diabetes, of which obesity is a key risk factor, having this condition in midlife is associated with a 19% greater cognitive decline over 20 years compared with not having the condition.16 Even those with prediabetes had significantly greater cognitive decline than those without.

Indeed, “Epidemiological studies have linked type-2 diabetes mellitus with cognitive impairment and dementia, with insulin resistance and hyperglycemia as the probable mechanistic links,” researchers noted.17

Coming full circle, eating a highly processed, junk food diet not only increases obesity risk but also can lead to normal but elevated blood sugar levels that, in turn, can lead to impaired glucose metabolism and Type 2 diabetes. Both diabetes and higher fasting glucose levels are linked with lower total brain volume.18

Impaired glucose metabolism is then associated with neurodegeneration that impairs cognitive function. This connection begins not in old age but much earlier, such that following a healthy lifestyle in young adulthood may be protective against cognitive decline later.19

The Inflammation Connection

Obesity can trigger chronic inflammation in your body, and chronic inflammation in your brain (neuroinflammation) is known to impair neurogenesis, your brain’s ability to adapt and grow new brain cells. It’s also linked to neurodegenerative disorders such as Alzheimer’s disease (AD), and it’s been suggested that “Obesity may serve as an amplifier or initiator of the chronic inflammation observed in AD patients.”20

Further, higher levels of inflammatory markers have also been associated with lower brain volume, including “greater atrophy than expected for age.”21 Excess body fat, particularly visceral fat, is also related to the release of proteins and hormones that can cause inflammation, which in turn can damage arteries and enter your liver, affecting how your body breaks down sugars and fats.

According to a study in the Annals of Neurology, “[A]dipose-tissue derived hormones, such as adiponectin, leptin, resistin or ghrelin, could also play a role in the relation between adipose tissue and brain atrophy.”22 Further, obesity may also be associated with lower volume in brain regions that regulate food-reward circuitry,23 possibly influencing overeating.

Strength Training Is Good for Your Brain

While obesity takes a toll on your brain, increased muscle mass protects it, which is likely one reason why strength training has been found to be beneficial for your brain. In other words, your body’s physical strength may serve as a marker of your brain power.

In fact, strength training is known to trigger beneficial neurobiological processes,24 leading to positive functional brain changes, including in the frontal lobe, with corresponding improvements in executive functions. One systematic review even found that strength training led to less white matter atrophy in the brain, with researchers noting:25

“Taken together, during aging processes, a substantial decline in muscular strength, especially in lower limb muscles, occurs, and accumulating evidence suggests that lower muscular strengths are linked to poorer cognitive performance.

Hence, resistance (strength) exercises (a single bout of resistance exercise, also referred to as acute exercise) and resistance (strength) training (more than one resistance exercise session, also referred to as chronic exercise … ) seem to be promising activities to ensure the preservation of physical functioning and cognitive functions with aging.”

Regular strength training, in addition to other forms of exercise and daily activity, is an important strategy for keeping your brain sharp and may help to offset some of the cognitive decline that occurs with age.

Avoid Obesity and Protect Your Brain With a Ketogenic Diet

While obesity may accelerate neurodegeneration, regular exercise to increase your muscle mass will be protective. Further, eating a ketogenic diet will help protect your brain from free radical damage and will supply the cells with preferred fuel while also helping you to lose weight and avoid obesity.

A ketogenic diet is high in healthy fats and low in net carbohydrates (total carbs minus fiber), prompting your body to start burning fat as its primary fuel, rather than sugar. This produces ketones, which not only burn efficiently but are also a superior fuel for your brain. Ketones also generate fewer reactive oxygen species (ROS) and less free-radical damage.

One of the simple strategies you can implement is to take ketone precursors like refined MCT oils of caprylic acid (C-8). The eight-chain carbon fats are readily converted to ketones. I personally use up to 5 ounces of our Ketone Energy when I have maxed out my protein and carb intake and need a source of healthy clean fat. This keeps my ketone level around 1 to 2.0 mmol/l. Just recognize that you have to build up to a high dose of MCT oil slowly or you will have problems with loose stools.

Recent studies have also demonstrated the benefits of nutritional ketosis for brain health. In one, researchers found a ketogenic diet improved neurovascular function, in part by improving your gut microbiome.26

In a second study, the researchers concluded a ketogenic diet acted as a veritable “fountain of youth” in their animal study by significantly improving neurovascular and metabolic functions, compared to the animals eating an unrestricted diet.27 Releasing ketones into your bloodstream helps preserve brain function and protects against cognitive impairment and other neurodegenerative diseases.28

KetoFasting, the program I developed and detail in my book, “KetoFast: A Step-By-Step Guide to Timing Your Ketogenic Meals,” combines a cyclical ketogenic diet and intermittent fasting with cyclical partial fasting to optimize health and longevity.

Not only can KetoFasting help you to lose weight, but your cognition typically improves thanks to the biological cleansing and regeneration that occurs throughout your body, including your brain.

Sources and References

TMG Benefits

TMG (Trimethylglycine) is a powerful nutrient, much like a vitamin, functioning as methyl donor, anti-oxidant, anti-inflammatory, energy booster, toxin remover, immune booster and more.
Also called betaine (first isolated from sugar beets) but different from Betaine Hydrochloride.

TMG the Methyl Donor

The TMG molecule comprises three methyl groups (CH3) joined to one molecule of glycine (C2H5NO2). The benefit of TMG is that it releases easily one, two, or all three of the methyl groups.
Releasing one methyl group then leaves behind DMG (Dimethylglycine) which is just TMG with only two methyl groups. Releasing all methyl groups leaves just Glycine, which is the smallest molecule of all of the amino acids, which allows it to go almost anywhere in the body, including crossing the blood-brain barrier.
DMG is considered a B-complex vitamin, shown to help:

  • Behaviour and speech in autistic children and adults
  • ADHD (Attention Deficit-Hyperactivity Disorder)
  • Neurological function
  • Reducing seizures
  • Stress tolerance
  • Oxygen utilisation
  • Liver activity
  • Athletic performance
  • Anti-aging
  • Anti-inflammatory
  • Anti-viral and anti-bacterial
  • Immune boosting
  • Shrinking tumours
  • Allergies
  • Chronic fatigue syndrome
  • Respiratory disorders
  • Alcoholism, drug addiction.
  • Cholesterol and triglycerides
  • Blood pressure
  • Blood glucose

Although DMG has all of these benefits, and is available as a supplement, LeanMachine recommends that people supplement with TMG as we then receive all of the benefits of DMG plus the benefit of 50% better methylation.

Methyl groups (CH3) are essential for millions of biochemical reactions every second in the body, these are a few examples:

  • Lowering homocysteine, an amino acid, which inflames arteries when levels rise, leading to “hardening of the arteries”. Homocysteine levels are a much better indicator of cardiovascular disease than cholesterol. High homocysteine is commonly caused by insufficient methyl groups. The body gets methyl groups from TMGActive FolateActive Vitamin B-12, SAM-eDMAEMethionineTaurine, Cysteine and Vitamin B-6.
    Other causes are mercury and copper toxicity. High homocysteine also causes methionine deficiency, in turn causing SAM-e (S-Adenosyl Methionine) deficiency which can lead to depression. Methionine is required for protein synthesis
  • Excess homocysteine also leads to osteoporosis, birth defects, cancer, ageing and free radicals, all helped by TMG
  • Methyl groups are required for the Phase 2, P450 liver detoxification pathway, a critical biochemical sequence of events. Fat-soluble toxins are joined to a methyl group, enabling a greater water solubility, then allowing the liver to remove them from the body. For toxins unable to be removed, methylation helps render them less toxic
  • TMG increases production of SAM-e, helping to reduce depression
  • TMG reduces risk of diabetes, as insulin release and insulin activity rely on methyl group donation
  • TMG donates methyl groups for protein synthesis (biosynthesis), the copying of genetic code from DNA to RNA (genetic transcription), then to the synthesis (formation) of every chemical in the body
  • TMG insufficiency causes biosynthesis slowing, telomeres shortening, and genetic errors (transcription errors) raises cancer risk from DNA mutations

The Methylation Process

This is a vital and most common chemical process in hundreds of essential chemical reactions, including:

  • Methylation is essential for manufacture of all the chemicals for the body
  • Stops certain viruses that could damage DNA
  • Stops the production of trophoblast (fast-growing cells that may lead to cancer)
  • Suppresses replication of DNA in areas where the body does not want it replicated
  • Important for neurological chemicals and blood chemicals
  • Corrects timing problems of the X chromosome in cell replication
  • Causea a genetic trait to come from only one parent, and not both
  • Prevents some genetic diseases
  • Helps prevent shortening of gene telomeres
  • Methylation is a primary method of removing toxins in the phase 2 liver detoxification system
  • Methylation converts toxins of all kinds from insoluble, less soluble or fat-soluble compounds into water-soluble compounds to allow excretion. Larger molecules are eliminated through the bile, smaller ones are excreted in the urine
  • Methylation is required for synthesis of dopamine and serotonin, improving mood, energy, wellbeing, alertness, concentration, and visual clarity
  • Methylation helps with liver detoxification
  • Methylation is required for conversion of homocysteine to methionine, which converts to other amino acids by various pathways
  • Methylation helps balance hormones such as estrogens, reducing risk of estrogen-related cancers
  • Reduces inflammation by removing toxins, balancing hormones, synthesising neurotransmitters and other methods
  • Methylation protects the mitochondria and adaptive energy production to stop us from becoming very tired
  • Restores SAM-e in spinal fluid, working as a methyl donor when restored by methyl groups
  • Methylation is required for the body to make CoQ10 (Coenzyme Q10), vital for heart health and energy production in the mitochondria
  • Methylation increases muscle mass, important in cancer and other wasting diseases, and for general health
  • Methylation may improve libido in some people

Who needs TMG?

Almost everyone needs supplemental TMG, even healthy people with a healthy diet, to provide enough methylation for modern life. Those subject to stress, toxins, cardiovascular disease, mental illness, depression, fatigue, exhaustion or almost any other medical condition, almost certainly need extra TMG.

Other benefits of TMG

The Parasympathetic System

TMG can improve the parasympathetic system, helping balance the autonomic nervous system. Hair mineral analyses show about half the population has an autonomic nervous system imbalance (sympathetic dominance), where the sympathetic (fight-or-flight) nervous system is “switched on” too often and too long, usually due to stress, causing many chronic health conditions. TMG may help reverse any imbalance, contributing to healing. Some doctors use “sympathetic dominance” in a different context such as “a sympathetic state of body chemistry” which is different from “sympathetic dominance” used here.

The MTHFR Defect

Almost half the people on Earth have the abnormal MTHFR gene expression, where the biosynthesis of folate is reduced, sometimes marginally, sometimes largely.
Often incorrectly called a “genetic defect” when it is actually a transcription error, polymorphism or abnormal gene expression where errors occur in copying the DNA code rather than a problem with the actual DNA code.
This is why Active Folate has benefits, as it is already in the (6S)-5-methyltetrahydrofolate form required by the body, while regular folate must be converted in the body to this form.
TMG can help supply the methyl groups where insufficent folate cannot. Active folate can be up to 700% more useful in the body, compared to regular folic acid. Note that folic acid is a cheap folate substitute used in many foods claiming to be “folate enriched” but folic acid may prevent absorption of real folate in foods or active folate supplements, and LeanMachine advises total avoidance of foods or supplements containing folic acid.

Antioxidant and anti-inflammatory

There are not many reports on these properties, but they do exist, possibly as a result of methyl group donation

Effects on the Brain

TMG has a positive effect on the brain, likely due to methylation and SAM-e production. Recommended for those at high risk for Alzheimer’s, dementia, Parkinsons, depression, anxiety, seizures, migraine headache, ADHD (Attention Deficit-Hyperactivity Disorder), MS (Multiple Sclerosis) and other brain conditions.

SAM-e Benefits

1. Heart Disease

SAM-e is used for heart disease, also for fibromyalgia, abdominal pain, osteoarthritis, bursitis, tendonitis, chronic lower back pain, ageing, CFS (Chronic Fatigue Syndrome), improving mental performance, liver disease, spinal cord injury, lead poisoning, to break down bilirubin or porphyrin (or precursors).

2. PMS

SAM-e is often taken for PMS (Premenstrual Syndrome) and a more severe form PMDD (Premenstrual Dysphoric Disorder).

IV use of SAM-e

IV (Intravenous) use of SAM-e is used for depression, osteoarthritis, AIDS-related nervous system disorders, fibromyalgia, liver disease, cirrhosis, and intrahepatic cholestasis (a liver disorder in pregnant women)

SAM-e Injections

SAM-e is often injected for fibromyalgia, depression, and Alzheimer’s disease.

Effects on Digestion

TMG aids digestion, again likely because of positive methylation throughout the body.

Glycine

Glycine is the component left over when all three methyl groups have been donated from TMG.
Glycine is the smallest of the amino acids and very important for collagen formation and many other functions. Collagen, the most abundant protein in the body, is used for connective tissue: Tendons, ligaments, cartilage, skin, nails, arteries, veins, etc. Without collagen, we could not stand up, our body would be a pile of mush on the floor!
Glycine, in large doses (up to 3000 mg daily), has been found helpful for sleep and alertness. Although not recommended as a first-line supplement for sleep, it may help if other supplements like Valerian fail to work. This may explain why TMG helps induce restful sleep in some individuals.

Natural sources of TMG

TMG is normally made in the body, but not enough when there are toxins present or the diet is poor or absorption of nutrients is a problem.
TMG can come from the diet. Foods high in TMG include broccoli, quinoa, spinach, lamb, chicken, and beets. A vegetarian or vegan diet tends to be very low in TMG. Foods high in TMG are usually also high in folate, and both are methyl donors.
However, most people do not eat enough of these foods, and even eating large amounts will not provide enough TMG for optimum health.

Risk factors for low TMG

Generally, the body cannot make enough, the modern diet is poor in TMG, and the number of pesticides, chemicals, heavy metal contamination uses up all TMG available.

  • Mercury is a poison that lowers TMG production in the body, and at the same time increases the need for TMG in the body. Almost everyone is mercury toxic now, as mercury is everywhere in the environment, especially in seafood and in dental amalgam fillings
  • Copper toxicity also interferes with TMG, and most people today are toxic from copper pipes, tapware, cookware even if blood or urine tests are negative. While copper is essential for the body to build hemoglobin in blood, we need Chelated Copper from food or supplements, not metallic copper from copper pipes and cookware. Zinc deficiencies cause accumulation of copper in the body, and women have a higher risk than men. Causes headaches, female organ problems, depression, anxiety, skin conditions. Too much zinc (and/or magnesium) competes with copper for absorption, often leading to a copper deficiency.

Supplements

Supplementary TMG is helpful for most people because of low body production, low in the diet, and higher requirements in our toxic world.
TMG 1000mg 100 tablets (most popular, best value).

Stress

Stress, inflammation, inflammation and some diseases increase our need for more TMG.

Dosage of TMG

  • Women: Up to 1000 mg daily
  • Men: Up to 3000 mg daily
  • Children: Less than adults, in proportion to body weight

There are no reliable guides or tests to determine TMG dosage, but the figures above should be a good starting point.
If the sodium/potassium ratio is low, extra TMG may help.
Do not overdose, as too much TMG may lead to over-methylation, causing fatigue, nausea, hair loss, dizziness or other symptoms.
Most people have no side effects from TMG apart from feeling better, getting better sleep and having more energy.
Cautions:
Do not continue a high dose for extended periods.
Children need proportionately less TMG than adults, depending on their size and weight, but babies generally do not need TMG. Older children may need about 250 to 500 mg daily.
TMG is available as tablets, liquid capsules or crystals. Some children and the elderly may have problems with swallowing tablets. TMG has a sweet taste, so TMG crystals can be simply added to food.
Some people have problems tolerating TMG, so they may need a smaller dose. Try reducing the dose until any symptoms disappear.
People who have unresolved resentments seem to have more problems taking TMG, as an enzyme is activated which can cause anger, fear, depression or anxiety symptoms. These symptoms disappear if the dose is reduced or eliminated, but if one can tolerate the symptoms, TMG may help the person resolve their issues of conflict.
Some reports suggest that too much TMG may cause diarrhea and nausea, and may raise cholesterol levels, so those with high cholesterol should keep the level monitored.

Poor Methylation

Several factors affect poor methylation, such as:

  • Raw vegetables are considered healthy, but cooked vegetables provide more dietary methyl groups
  • Sugars in any form appear to harm correct methylation, and are bad for our health anyway
  • Fermented foods are healthy, but are problem for methylation because:
    • Some contain aldehydes (toxic to the liver), including kombucha tea, kimchi, and most fermented grains
    • They contain ferments, which are bacteria or yeasts

    Safer fermented foods, eaten in moderation, include yogurt, kefir, miso and most good quality cheeses

  • Too much animal protein in the diet can cause high methionine and reduce methylation
  • Fighting inflammation or infections consumes methyl groups, requiring more methylation
  • Heavy metal toxicity, especially copper and mercury, interfere with methyl group formation
  • High-dose niacin or niacinamide cause the body to use up methyl groups to detoxify and excrete niacin through the liver. Doses less than 50 mg daily are generally tolerated well
  • Any liver toxins will reduce formation of methyl donors, also liver detoxification pathways require methyl groups, using up more methyl groups
  • Methyl donor production seems to decrease with age, so seniors need more TMG
  • Women of child-bearing age have much better methylation than men. Men always need more TMG than women

Methylation and Cancer

Cancer increases the need for methylating agents like TMG. People often die with cancer because they cannot eliminate their toxic metals and chemicals because of poor liver methylation, so toxins accumulate until death occurs.

Hair Mineral Analysis

More TMG may be required if a hair mineral test reveals:

  • High zinc level, which may indicate presence of hidden toxic metals
  • “Four lows pattern” meaning all four electrolyte minerals low: Calcium, Magnesium, Sodium, Potassium. Indicates impaired methylation
  • High mercury, becoming more common
  • High copper
  • High levels of the other toxic metals

These results indicate long-term toxic metal exposure.

LeanMachine online supplemments

Disclaimer

LeanMachine is not a doctor, and everyone should consult with their own health professional before taking any product to ensure there is no conflict with existing prescription medication.
LeanMachine has been researching nutrition and health since 2010 and has completed many relevant studies including:
Open2Study, Australia – Food, Nutrition and Your Health
RMIT University, Australia – Foundations of Psychology
Swinburne University of Technology, Australia – Chemistry – Building Blocks of the World
University of Washington, USA – Energy, Diet and Weight
Johns Hopkins Bloomberg School of Public Health, USA – Health Issues for Aging Populations
Johns Hopkins Bloomberg School of Public Health, USA – International Nutrition
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics I
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics II
Johns Hopkins Bloomberg School of Public Health, USA – Principles of Human Nutrition
TUFTS University, USA – Nutrition and Medicine
TUFTS University, USA – Lipids/Cardiovascular Disease I and Lipids/Cardiovascular Disease II
Technical Learning College, USA – Western Herbology, Identification, Formulas
Bath University, England – Inside Cancer
WebMD Education – The Link Between Stroke and Atrial Fibrillation
WebMD Education – High Potassium: Causes and Reasons to Treat
Leiden University Medical Center, Netherlands – Anatomy of the Abdomen and Pelvis
MIT (Massachusetts Institute of Technology) – A Clinical Approach to the Human Brain
LeanMachine has now examined thousands of studies, journals and reports related to health and nutrition and this research is ongoing.

Updated 9th January 2020, Copyright © 1999-2020 Brenton Wight and BJ & HJ Wight trading as Lean Machine abn 55293601287

Glutathione and NAC Play Crucial Roles in Health and Fitness


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2019/12/30/glutathione-nac-for-health-and-fitness.aspx

Analysis by Dr. Joseph Mercola Fact Checked image
glutathione nac for health and fitness

STORY AT-A-GLANCE

  • Sulfur is the third most abundant mineral in your body. Sulfur-containing amino acids increase your levels of glutathione and N-acetylcysteine (NAC), which play important roles in health and fitness
  • Glutathione metabolism influences the control of epigenetic mechanisms at several levels, including substrate availability, enzymatic activity for DNA methylation and the expression of microRNAs
  • NAC supplementation may be useful for the prevention of cardiovascular problems in older people by lowering oxidative stress and improving mitochondrial function
  • Glutathione deficiency can induce epigenetic changes in genes that regulate vitamin D metabolism in the liver, and research suggests glutathione supplementation could help reduce the risk of vitamin D deficiency in obese individuals
  • Glutathione and NAC also ameliorate exercise-induced stress and reduce muscle fatigue. Glutathione may also play a central role in chronic fatigue syndrome

As explained in “The Health Benefits of MSM,” sulfur is the third most abundant mineral in your body and plays important roles in a variety of bodily processes, including metabolism and detoxification, and for maintaining the proper shape and structure of proteins and enzymes.

Sulfur-containing amino acids increase your levels of glutathione and N-acetylcysteine (NAC), and these two play important roles in health and fitness.

Glutathione Basics

Glutathione comprises three amino acids: cysteine, glutamate and glycine. It’s commonly referred to as “the master antioxidant,” as it is your body’s most powerful antioxidant, and is found inside every cell in your body.

Antioxidants combat free radicals — highly reactive particles that bounce around the cell, damaging everything they touch. Most originate during the process of metabolism but they can also arise during exercise, and from exposure to toxins, irradiation and toxic metals.

Because free radicals are so destructive, cells have a network of defenses designed to neutralize them. This antioxidant network is composed of numerous components that include vitamins, minerals and special chemicals called thiols (glutathione and alpha-lipoic acid).

Glutathione differs from other antioxidants in that it is intracellular, and has the unique ability of maximizing the activity of all the other antioxidants, including (but not limited to) vitamins C and E, CoQ10 and alpha lipoic acid. It also removes toxins from your cells and protects you from the damaging effects of radiation, chemicals and environmental pollutants.

NAC Basics

NAC is a precursor to and rate-limiting nutrient for the formation of glutathione.1 Glutathione is poorly absorbed so, in many cases, it’s easier to raise your glutathione by taking NAC instead.

In emergency medicine, NAC is used as an antidote for acetaminophen toxicity resulting from an overdose.2 Mortality due to acetaminophen toxicity has been shown to be virtually eliminated when NAC is promptly administered.

It is believed the liver damage acetaminophen causes is largely due to the fact that it can deplete glutathione, which is secreted by your liver in response to toxic exposure.

On a side note, NAC supplementation can also help “pre-tox” your body when taken before alcohol, thereby minimizing the damage associated with alcohol consumption — a tidbit that may be useful to know in light of approaching New Year’s celebrations.

Taking NAC (at least 200 milligrams) 30 minutes before you drink can help lessen the alcohol’s toxic effects. Vitamin B6 may also help to lessen hangover symptoms.

While the most common use of NAC is for liver support, it’s also showing promise as a neuroprotectant.3 Scientists are currently investigating it as a treatment for Parkinson’s disease, which has been linked to glutathione deficiency in the substantia nigra, a region that houses dopamine neurons.4

Research looking at autopsied brains suggests Parkinson’s patients have barely detectable levels of glutathione in this brain region. Subsequent studies have found glutathione deficiency in the substantia nigra is common in a number of other neurodegenerative conditions as well, including Alzheimer’s disease.5

Another area where NAC shows particular promise is in the treatment of mental health disorders, including post-traumatic stress disorder,6 depression7 and substance use disorders.8 Dozens of additional health benefits are also reviewed in a November 29, 2019, SelfHacked article.9

Advertisement

Get 20 health resolutions for 2020 here


Glutathione Helps Regulate Epigenetic Disease Mechanisms

One factor that can help explain the wide-ranging benefits of NAC and glutathione is glutathione’s role in the regulation of epigenetic disease mechanisms.10 As noted in a November 2017 paper in Free Radical Biology and Medicine:11

“Epigenetics is a rapidly growing field that studies gene expression modifications not involving changes in the DNA sequence.

Histone H3, one of the basic proteins in the nucleosomes that make up chromatin, is S-glutathionylated in mammalian cells and tissues, making Gamma-L-glutamyl-L-cysteinylglycine, glutathione (GSH), a physiological antioxidant and second messenger in cells, a new post-translational modifier of the histone code that alters the structure of the nucleosome.

However, the role of GSH in the epigenetic mechanisms likely goes beyond a mere structural function. Evidence supports the hypothesis that there is a link between GSH metabolism and the control of epigenetic mechanisms at different levels (i.e., substrate availability, enzymatic activity for DNA methylation, changes in the expression of microRNAs, and participation in the histone code).”

The following graphic12 illustrates how glutathione influences pathological changes in gene expression.

glutathione influences pathological changes in gene expression

NAC Improves Cardiovascular and Mitochondrial Function

According to a 2018 study,13 NAC supplementation may be useful for the prevention of cardiovascular problems in older people. As you might expect, oxidative stress can over time induce metabolic and functional changes that speed cardiovascular aging and dysfunction, and your glutathione levels declines with age, putting you at greater risk.

In this study, aging mice received either NAC or a combination of NAC and glycine. After seven weeks, their cardiac function was assessed, showing those receiving NAC plus glycine had improved several parameters of their cardiovascular function, including:

  • Improved diastolic function
  • Increased peak early filling velocity
  • Reduced relaxation time
  • Reduced left atrial volume
  • Reduced left ventricle end diastolic pressure

NAC alone did not impart these cardiovascular benefits, although both groups had decreased levels of inflammatory mediators. The NAC and glycine combination also improved mitochondrial function and upregulated mitochondrial genes in the heart that are normally downregulated with age.

According to the authors, “Our data indicate that NAC+Gly supplementation can improve diastolic function in the old mouse and may have potential to prevent important morbidities for older people.”

Glutathione Deficiency Lowers Vitamin D Levels in the Obese

Other recent research14 published in Scientific Reports shows that glutathione deficiency can induce epigenetic changes in genes that regulate vitamin D metabolism in the liver. Emerging evidence also suggests glutathione metabolism plays a role in the epigenetic regulation of oxidation-reduction (redox) reactions, the authors note.

According to this paper,15 obesity has been correlated with low levels of glutathione and 25-hydroxyvitamin D3 — especially in Type 2 diabetics and the obese16 — and when obese mice were fed a glutathione-deficient diet, it downregulated vitamin D metabolism genes and vitamin D receptors in the liver. As a result, oxidative stress increased.

According to the authors, their findings suggest glutathione supplementation could help reduce the risk of vitamin D deficiency in obese individuals. Supplementation with L-cysteine, a rate-limiting precursor to glutathione, has also been shown to increase vitamin D levels and reduce oxidative stress, the paper notes, which supports the link between glutathione and vitamin D.

Glutathione and NAC Ameliorate Exercise-Induced Stress

As mentioned earlier, exercise is one of the ways through which free radical production increases and, with it, oxidative stress. Provided you get enough rest between bouts, this oxidative stress is actually part of what makes exercise so beneficial.

That said, as noted in a 2005 paper,17 “Effective regulation of the cellular balance between oxidation and antioxidation is important when considering cellular function and DNA integrity as well as the signal transduction of gene expression.” In other words, excessive exercise can cause more harm than good. As explained by the authors:18

Exercise enthusiasts and researchers have become interested in recent years to identify any means to help minimize the detrimental effects of oxidative stress that are commonly associated with intense and unaccustomed exercise. It is possible that a decrease in the amount of oxidative stress a cell is exposed to could increase health and performance …

To protect against the deleterious effects of ROS [reactive oxygen species], our bodies have a complex system of endogenous antioxidant protection in the form of enzymes such as superoxide dismutase, catalase, and glutathione peroxidase. Under normal, resting conditions reactive oxygen species are removed from the cell preventing any subsequent damage.

However, under more extreme conditions such as: 1) inadequate intake of foodstuffs containing the antioxidants, 2) excessive intake of pro-oxidants, 3) exposure to noxious chemicals or ultraviolet light, 4) injury/wounds, and/or 5) intense exercise, especially eccentric exercise, the body’s endogenous antioxidant system is not able to effectively remove excessive ROS production.

In situations such as the ones listed above in which the production of pro-oxidant molecules increase to a point where the antioxidant system cannot effectively remove them is when oxidative stress is known to occur.

Oxidative stress has been implicated in a number of diseases which include atherosclerosis, pulmonary fibrosis, cancer, Parkinson’s disease, multiple sclerosis, and aging. Research on oxidative stress during exercise has begun to indicate that regular training enhances the ability of these mechanisms to effective respond to the increase of oxidative product.”

Exercise Boosts Your Glutathione Level

The 2005 paper above goes on to explain how exercise affects your glutathione level, and thus your health, fitness and risk of disease. In short, when you engage in intense exercise, your blood level of glutathione significantly decreases while circulating levels of oxidized glutathione increases, indicating that it’s been used inside the muscle to quench free radicals produced during the exertion.19

Considering the importance of glutathione to counteract free radicals, effective regulation of glutathione levels when exercising is a significant concern. The good news is that the more you exercise, the higher your base levels of glutathione get.

This adaptation allows your body to effectively deal with the increase in free radicals that the exercise brings about. While exercise itself will boost your glutathione level over time, raising glutathione through supplementation is an oft-used strategy among athletes.

As mentioned, glutathione supplementation is ineffective due to its poor absorption, so NAC is generally considered a much better choice. According to the authors of the 2005 paper cited above:20

“In addition to the role glutathione and other thiols have on maintaining the cellular redox state, many studies have begun to explore if NAC supplementation can actually improve performance due to its ability to promote a more favorable cellular environment to achieve higher levels of performance …

One of the first studies to utilize NAC to determine its role in improving muscle performance was conducted by Reid and colleagues. They pretreated subjects with n-acetyl-cysteine infusion (150 mg/kg) or a 5% dextrose placebo while undergoing an extended fatiguing bout of electrical stimulation of the ankle dorsiflexors.

N-acetyl-cysteine was found to have no impact over the nonfatigued muscle, but a significantly increased force output of approximately 15% was found after 3 minutes of repetitive contractions which persisted throughout the 30-minute protocol. The authors concluded that NAC resulted in improved performance suggestive of oxidative stress having a causal role in the fatigue process.”

Other studies have also confirmed that NAC supplementation helps delay muscle fatigue during exercise, thereby improving endurance. In one study,21 NAC infusion increased the time to exhaustion by 26.3%.

NAC’s ability to reduce fatigue and improve cellular redox (oxidation reduction) also hints at its potential benefit for those struggling with chronic fatigue syndrome (CFS).

The Glutathione Depletion Theory of CFS

As explained by the U.S. Centers for Disease Control and Prevention, CFS, also known as myalgic encephalomyelitis or ME, is characterized by “overwhelming fatigue that is not improved by rest.”22 The fatigue is frequently such that it challenges your ability to perform even the most common of daily life tasks, such as showering or preparing a meal.

The role of glutathione in this condition is addressed in “A Simple Explanation of the Glutathione/Methylation Depletion Theory of ME/CFS”23 by the late Rich Van Konynenburg, Ph.D., developer of the methylation protocol used by many in the CFS community.24,25

According to Van Konynenburg, oxidative stress “is probably the best-proven biochemical aspect of chronic fatigue syndrome,” and in order for your oxidative stress to overwhelm your system, something must be placing excessive demands on your glutathione supply.

Several examples were already listed above, such as inadequate antioxidant and/or excessive pro-oxidant intake, toxic exposures and physical injuries. Long-term emotional stress can also be a factor. As noted in Van Konynenburg’s article:

“All people experience a variety of stressors all the time, and a healthy person’s body is able to keep up with the demands for glutathione by recycling used glutathione molecules and by making new ones as needed.

However, if a person’s body cannot keep up, either because of extra-high demands or inherited genetic polymorphisms that interfere with recycling or making glutathione, or both, the levels of glutathione in the cells can go too low …

One of the jobs that glutathione normally does is to protect your supply of vitamin B12 from reacting with toxins … When your glutathione level goes too low, your B12 becomes naked and vulnerable, and is hijacked by toxins.

Also, the levels of toxins rise in the body when there isn’t enough glutathione to take them out, so there are two unfortunate things that work together to sabotage your B12 when glutathione goes too low.”

The B12-Glutathione Connection

Vitamin B12 helps your body convert food into glucose for energy, and fatigue is one of the symptoms of low B12 levels.26 Interestingly, many with CFS have elevated B12 levels. Their bodies simply cannot use it properly, and one potential culprit is low glutathione.

“The best test to reveal this is a urine organic acids test that includes methylmalonic acid. It will be high if the B12 is being sidetracked, and this is commonly seen in people with CFS,” Van Konynenburg states, adding:27

“The most important job that B12 has in the body is to form methylcobalamin, which is one of the two active forms of B12. This form is needed by the enzyme methionine synthase, to do its job. An enzyme is a substance that catalyzes, or encourages, a certain biochemical reaction.

When there isn’t enough methylcobalamin, methionine synthase has to slow down its reaction. Its reaction lies at the junction of the methylation cycle and the folate cycle, so when this reaction slows down, it affects both these cycles …

The methylation cycle has some important jobs to do. First, it acts as a little factory to supply methyl (CH3) groups to a large number of reactions in the body. Some of these reactions make things like creatine, carnitine, coenzyme Q10, phosphatidylcholine, melatonin, and lots of other important substances for the body.

It is not a coincidence that these substances are found to be low in CFS … Not enough of them is being made because of the partial block in the methylation cycle.

The methylation cycle also supplies methyl groups to be attached to DNA molecules, and this helps to determine whether the blueprints in the DNA will be used to make certain proteins according to their patterns.

The ‘reading’ of DNA is referred to as ‘gene expression.’ Methyl groups prevent or ‘silence’ gene expression. Overexpression of genes has been observed in CFS patients, and I suspect this is at least partly due to lack of sufficient methylation to silence gene expression.”

The Basic Biochemical Mechanism of CFS

The methylation cycle also regulates your body’s use of sulfur, and the production of sulfur-containing substances, including glutathione. CFS patients often have abnormal levels of sulfur metabolites. Once you understand the interconnectedness of glutathione, B12 and the methylation cycle, it becomes easier to see how chronic CFS arises. As explained by Van Konynenburg:28

“When glutathione goes too low, the effect on vitamin B12 slows down the methylation cycle too much. The sulfur metabolites are then dumped into the transsulfuration pathway (which is connected to the methylation cycle) too much, are oxidized to form cystine, pass through hydrogen sulfide, and are eventually converted to thiosulfate and sulfate and are excreted in the urine.

This lowers the production of glutathione, which requires cysteine rather than cystine, and now there is a vicious circle mechanism that preserves this malfunction and keeps you sick … That’s the basic biochemical mechanism of CFS … everything else flows from this …

Here’s how I believe the fatigue occurs: The cells have little powerplants in them, called mitochondria. Their job is to use food as fuel to produce ATP (adenosine triphosphate). ATP acts as a source of energy to drive a very large number of reactions in the cells.

For examples, it drives the contraction of the muscle fibers, and it provides the energy to send nerve impulses. It also supplies the energy to make stomach acid and digestive enzymes to digest our food, and many, many other things.

When glutathione goes too low in the muscle cells, the levels of oxidizing free radicals rise, and these react with parts of the ‘machinery’ in the little powerplants, lowering their output of ATP.

So the muscle cells then experience an energy crisis, and that’s what causes the fatigue. Over time, because of the lack of enough glutathione, more problems accumulate in the mitochondria, including toxins, viral DNA, and mineral imbalances.”

All of these factors will ultimately decimate your immune function as well, allowing pathogenic bacteria, viruses and fungi to take over. CFS patients will frequently have several infections ongoing at the same time. Low glutathione also impedes your body’s natural detoxification pathways, allowing toxicity to build over time, thereby causing ever-increasing dysfunction.

The Answer for CFS

So, how do you turn this chain of events around? As noted in Van Konynenburg’s article:29

“The main key to turning this process around is to help the methionine synthase enzyme to operate more normally, so that the partial block in the methylation cycle and the folate cycle are lifted, and glutathione is brought back up to normal. That is what the simplified treatment approach is designed to do, and so far, the evidence is that it does do these things in most people who have CFS.

I recommend that people with CFS have the Vitamin Diagnostics methylation pathways panel run to find out if they do in fact have a partial methylation cycle block and glutathione depletion before deciding, with their doctors, whether to try this treatment.

This also provides a baseline so that progress can be judged later on by repeating it every few months during the treatment. Symptoms may not be a good guide to judge progress during treatment, because detoxing and die-off can make the symptoms worse, while in fact they are exactly what is needed to move the person toward recovery.”

An outline of Van Konynenburg’s simplified methylation treatment plan for CFS can be found in HealthRising.org.30 At the core of this treatment is the use of specific supplements, including folate, B12, a multivitamin, SAMe and phosphatidyl serine.

In his protocol, he explains the theory behind the use of each of these supplements, how they impact the methylation cycle, and their interactions with other supplements.

My take-home message here is that glutathione and NAC supplementation may not always be the ideal way to go. People with CFS may be better supported by a customized assessment by an experienced clinician that may also include methyl folate and methyl vitamin B12.

General Dosing and Safety Guidelines for NAC

For many others, however, NAC can be safely used to boost glutathione levels. For more information about how NAC can benefit your health, see “The Many Benefits of NAC.” It’s widely available as an oral dietary supplement and is relatively inexpensive. Unfortunately, like glutathione, NAC is poorly absorbed when taken orally, although it’s better than glutathione.

According to some studies,31,32 NAC’s oral bioavailability may range between 4% and 10%, which is why the recommended dosage can go as high as 1,800 milligrams (mg) per day. Its half-life is also in the neighborhood of two hours, which is why most study subjects take it two or three times a day.

No maximum safe dose has yet been determined, but as a general rule, it’s well-tolerated, although some do experience gastrointestinal side effects such as nausea, diarrhea or constipation. Should this occur, reduce your dosage. It’s also best taken in combination with food, to reduce the likelihood of gastrointestinal effects.

Also keep in mind that since NAC boosts glutathione, which is a powerful detox agent, you may experience debilitating detox symptoms if you start with too high a dose. To avoid this, start low, with say 400 to 600 mg once a day, and work your way up.

Also, if you are currently taking an antidepressant or undergoing cancer treatment, be sure to discuss the use of NAC with your physician, as it may interact with some antidepressants and chemotherapy.

 Sources and References

Does Vitamin D Supplementation Prevent Cancer and Cardiovascular Disease?


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2019/12/17/vitamin-d-supplements-disease-prevention.aspx

Analysis by Dr. Joseph MercolaFact Checked
vitamin d supplements disease prevention

STORY AT-A-GLANCE

  • Recent research claims “high dose” vitamin D supplementation did not result in a lower incidence of cancer or cardiovascular events than placebo
  • The “high dose” given in this trial was a mere 2,000 international units (IUs) a day, which is still only a quarter or less of what many need to raise their blood level into a protective range
  • The study did not test and track participants’ vitamin D blood levels, which is the only way to ensure sufficiency and adherence to the protocol
  • Cancer is a slow-growing disease and effects of nutritional intervention typically only become evident after several years. When the first two years of follow-up data were excluded, people who took 2,000 IUs of vitamin D3 per day had a 25 percent lower risk of cancer in the years following (years three through five)
  • Many need upward of 10,000 IUs a day in order to achieve a blood level of 40 ng/mL (100 nmol/L) or higher, which is the bottom cutoff for health and disease prevention. Ideally, you’ll want a level between 60 and 80 ng/mL (150 and 200 nmol/L)

The effectiveness of vitamin D supplementation has again been questioned with negative headlines1,2 trumpeting its failure to prevent cancer and cardiovascular disease. What most researchers and journalists fail to address, however, is the fact that:

  • The “high dose” given in this trial was a mere 2,000 international units (IUs) a day, which is still only a quarter or less of what many need to raise their blood level into a protective range
  • They did not test and track participants’ vitamin D blood levels, which is the only way to ensure sufficiency

Based on those two factors alone, a negative result is precisely what one would predict. Still, despite such limitations, the study actually found some rather remarkable benefits that were simply glossed over.

In fact, had it been a drug trial, vitamin D would likely have been declared a miracle drug against both cancer and cardiovascular disease, based on the findings. This is the kind of perversion of science and selective reporting that shackles public health.

VITAL Study Conclusions

The study3,4 in question, which was in part funded by the U.S. National Institutes of Health, was published in the January 2019 issue of the New England Journal of Medicine (NEJM). (A second study5 compared omega-3 supplementation against placebo for the same endpoints.) As detailed in the vitamin D paper, the study was:

“[A] nationwide, randomized, placebo-controlled trial, with a two-by-two factorial design, of vitamin D3 (cholecalciferol) at a dose of 2000 IU per day6 and marine n−3 (also called omega-3) fatty acids at a dose of 1 gram per day7 for the prevention of cancer and cardiovascular disease among men 50 years of age or older and women 55 years of age or older in the United States.

Primary end points were invasive cancer of any type and major cardiovascular events (a composite of myocardial infarction, stroke or death from cardiovascular causes). Secondary end points included site-specific cancers, death from cancer and additional cardiovascular events.”

In conclusion, the authors determined that “Supplementation with vitamin D did not result in a lower incidence of invasive cancer or cardiovascular events than placebo.”

What the VITAL Data Actually Reveals

However, as noted by GrassrootsHealth,8 a nonprofit public health research organization dedicated to moving public health messages regarding vitamin D and omega-3 from research into practice, “when the separate types of heart disease or death from cancer were analyzed, there were 30 different very significant results,” summarized in the graph9 below.

risk reduction vitamin d omega-3

Importantly, when the researchers excluded data from the first two years of supplementation, cancer mortality “was significantly lower with vitamin D than with placebo.”10 The reason this is important is because cancer is a slow-growing disease and effects of nutritional intervention typically only become evident after several years. It’s unreasonable to think you can take a supplement and within weeks or months see a drastic difference in health outcomes. The paper states that clearly, and adds:

“Supplemental vitamin D also did not reduce the occurrence of breast, prostate or colorectal cancers. However, there was a suggestive 17 percent reduction in cancer deaths, which became a 25 percent reduction in analyses that excluded the first two years of follow-up.”

Let me repeat those two points for clarity:

  1. While incidence of breast, prostate and colorectal cancers were unaffected, those who took a non-ideal dose of vitamin D3 supplements still had a 17 percent lower risk of actually dying from those cancers
  2. When the first two years of follow-up data were excluded, people who took a mere 2,000 IUs of vitamin D3 per day had a 25 percent lower risk of cancer in the years following (years three through five)

How is this not good news? Again, let’s remember that 2,000 IUs is really insufficient for most people, yet even at this insufficient dosage, the risk of cancer was cut by 25 percent.

For Most, 2,000 IUs a Day Is Suboptimal for Cancer Prevention

In years past, it was widely believed that 4,000 IUs was the upper safe limit, above which you risked vitamin D toxicity, but studies have since refuted this, showing there’s no risk of toxicity until you hit 30,000 IUs a day, or a blood level of 200 ng/ml (500 nmol/L).11 Still, the misconception persists.

A significant body of research shows many need upward of 10,000 IUs a day in order to achieve a blood level of 40 ng/mL (100 nmol/L) or higher, which is the bottom cutoff for health and disease prevention. Ideally, you’ll want a level between 60 and 80 ng/mL (150 and 200 nmol/L). This is where the majority of health benefits become really apparent.

As noted in a 2009 study12 on athletic performance and vitamin D, “At levels below 40 to 50 ng/mL the body diverts most or all of the ingested or sun-derived vitamin D to immediate metabolic needs, signifying chronic substrate starvation (deficiency).”

As noted earlier, the VITAL study did not use vitamin D blood levels as the marker for deficiency or sufficiency, and this is perhaps the most significant problem with this study. Blood levels were only measured in a subgroup of 1,644 participants (out of 25,871) after the first year of daily supplementation.

In this group, the mean vitamin D blood level increased from 29.8 ng/mL (74 nmol/L) at baseline to 41.8 ng/mL (104 nmol/L). In other words, most of those taking vitamin D supplements had barely adequate vitamin D levels, and were still significantly short of having ideal blood levels — levels at which research shows the risk of cancer is cut up to 80 percent.

Why You Cannot Trust Studies That Base Results on Dosage Rather Than Blood Measurement

This certainly is not the first time studies have claimed vitamin D supplementation is useless. Last year, a meta-analysis13 concluded once-a-month high-dose vitamin D supplementation had no impact on cancer risk. Here, participants received an initial bolus dose of 200,000 IUs of vitamin D, followed by a monthly dose of 100,000 IUs (so-called pulsed or pulsatile dosing) for a median of three years.

While the media played this up as a finding contradicting recommendations to optimize your vitamin D to lower your cancer risk, it really only made a case against once-a-month mega-dosing. As noted by GrassrootsHealth scientists, for optimal results, you need to supplement frequently (ideally daily) and focus on the achieved serum level, not the dosage.

What’s more, 100,000 IUs per month actually only comes out to about 3,000 IUs per day, which again is far below what most adults need to raise their vitamin D serum level into the protective range of 60 to 80 ng/mL, with 40 ng/mL being the low-end cutoff for sufficiency.

Indeed, this analysis noted the mean baseline vitamin D concentration was just over 26 ng/mL, and the mean follow-up level was just 20 ng/mL higher in the supplement group than the placebo group that received no vitamin D.

As in the current NEJM study, participants’ vitamin D levels were also not measured regularly throughout the study, and the association with cancer was not analyzed by serum level but by daily dosage.

This point really cannot be stressed enough: The key factor is not how much vitamin D you take but whether or not your blood level of vitamin D is within the “Goldilocks’ zone” of 60 to 80 ng/mL, and the only way to ascertain that is through blood testing.

How to Assess Study Quality

GrassrootsHealth scientists have also argued that pulsatile dosing at intervals greater than two weeks may actually cause a form of vitamin D deficiency at the cellular level.

According to GrassrootsHealth, to accurately ascertain the benefit of vitamin D in any given trial, researchers must track not only the baseline and final vitamin D serum level plus the dose given, but also the form (vitamin D2 versus D3) and the dosing interval.

Adherence to protocol is also measured by blood level. If a participant’s blood level doesn’t change, you know that individual was probably not taking the supplement as instructed, rendering their result null and void.

All of these factors can influence the results, and it’s important to get them all right. Identifying the ideal parameters are all part of what GrassrootsHealth is doing. Another study, published in 2017, claimed it found “no case” for vitamin D supplementation during pregnancy.14

In reality, it found seven positive outcomes,15 including increased birth weight, a 40 percent reduction in gestational diabetes, an 18 percent reduction in preeclampsia and a 17 percent reduction in gestational hypertension.

What this study failed to find was a reduction in preterm birth, and this was ultimately translated into headlines that made it appear as though pregnant women have no need for vitamin D supplementation! In reality, nothing could be further from the truth.16,17

So, in summary, when evaluating vitamin D research, the following parameters are what you’re looking for in a high-quality study, as without these, the results are likely to be significantly flawed and likely negative:

Supplementation should be frequent, ideally daily — Bolus doses given at intervals greater than two weeks are likely to be ineffective. According to Carole Baggerly, director and founder of GrassrootsHealth, pulsatile dosing at intervals greater than two weeks may actually cause a form of vitamin D deficiency at the cellular level.

Dosage, baseline and final vitamin D serum level must all be tracked — Most studies fail in this regard, as most only track dosage and not serum level, which is the most crucial parameter of all.

In short, it doesn’t matter how large or small the dose is, as long as it gets the participants into a specific blood level range, as the individual response to any given dose varies widely, depending on several different factors, including intake of other nutrients (such as magnesium), age, ethnicity, body weight and amount of sun exposure.

The form of vitamin D must be identified — Are they using vitamin D2 or D3? And are they tracking sun exposure, which is the primary way your body produces vitamin D?

There’s Strong Evidence Vitamin D Lowers Your Chronic Disease Risk

Vitamin D, a steroid hormone, is vital for the prevention of many chronic diseases, including but not limited to:

  • Type 2 diabetes
  • Age-related macular degeneration (the leading cause of blindness)
  • Alzheimer’s disease
  • Heart disease
  • Well over a dozen different types of cancer, including skin cancer — the very cause of concern that has led so many to avoid the sun exposure necessary for vitamin D production

In the case of heart disease, vitamin D plays a vital role in protecting and repairing damage to your endothelium.18 It also helps trigger production of nitric oxide — which improves blood flow and prevents blood clot formation — and significantly reduces oxidative stress in your vascular system, all of which are important to help prevent the development and/or progression of cardiovascular disease.

Just last year, a Norwegian study19 published in The Journal of Clinical Endocrinology and Metabolism found “a normal intake of vitamin D” significantly reduces your risk of death if you have cardiovascular disease.20

According to vitamin D researcher Dr. Michael Holick, vitamin D deficiency — defined as a level below 20 ng/mL (50 nmol/L) — can also raise your risk of heart attack by 50 percent, and if you have a heart attack while vitamin D deficient, your risk of dying is nearly guaranteed.

Vitamin D also has powerful infection-fighting abilities, making it a useful aid in the treatment of tuberculosis, pneumoniacolds and flu, while maintaining a healthy vitamin D level will typically prevent such infections from taking root in the first place. Studies have also linked higher vitamin D levels with lowered mortality from all causes.21,22,23

A Majority of Breast Cancer Cases Could Be Avoided by Raising Vitamin D Levels Among the General Public

Importantly, the ongoing research by GrassrootsHealth has firmly established that 20 ng/mL, which is conventionally considered the cutoff for sufficiency, is nowhere near sufficient for optimal health and disease prevention.

As mentioned, 40 ng/mL (100 nm/L) appears to be at the low end of optimal, and most participants in the featured NEJM study were likely hovering right around this low-end blood level (based on measurements from a very limited subgroup).

Still, recall the risk of cancer in Years 3 through 5 among those who supplemented with 2,000 IUs a day (thereby reaching a mean blood level of just under 42 ng/mL) went down by 25 percent. GrassrootsHealth research shows the ideal protective range is between 60 and 80 ng/mL (150 to 200 nm/L), and the higher the better within this range.

Research has actually demonstrated that most cancers occur in people with a vitamin D blood level between 10 and 40 ng/mL.24,25 Meanwhile, research shows women with vitamin D levels above 60 ng/mL have an 83 percent lower risk of breast cancer than those with levels below 20 ng/mL.26 Data from GrassrootsHealth ongoing D*Action study actually suggests 80 percent of breast cancer incidences could be prevented simply by optimizing vitamin D and nothing else!

breast cancer rates vitamin d level

The key, however, is to achieve the proper blood level, which has nothing to do with dosage. And the reason this correlation has never been elucidated before is because no one was using high-enough dosage to actually get participants vitamin D levels above 60 ng/mL, which is where you really start seeing these dramatic reductions in disease.

Optimizing Your Vitamin D Is a Key Disease Prevention Strategy

The evidence in support of vitamin D optimization is overwhelming, and becomes all the more compelling when the blood level is the primary parameter being measured and tracked. The key take-home message here is that 2,000 IUs is insufficient for most people, although it may still cut the risk of cancer by about 25 percent.

Overall, research supports the idea that higher levels offer greater cancer protection, and even levels as high as 100 ng/mL appear safe and beneficial. Importantly, having a serum vitamin D level of 60 ng/mL has been shown to positively impact anyone with breast cancer or Type 1 diabetes, as well as pregnant women and lactating mothers.

It’s a shame that so many researchers still have not grasped the importance of measuring blood levels rather than simply going by dosage, and relatively low dosages at that. In reality, what this NEJM study (and others like it) show is that insufficient vitamin D dosage fails to achieve optimal results. It’s not that vitamin D itself is useless. GrassrootsHealth D*Action study is clearly leading the pack here, revealing what’s required.

It’s an ongoing study that relies on public participation, and you can join at any time. To participate, simply purchase the D*Action Measurement Kit and follow the registration instructions included. (Please note that 100 percent of the proceeds from the kits go to fund the research project. I do not charge a single dime as a distributor of the test kits.)

As a participant, you agree to test your vitamin D levels twice a year during a five-year study, and share your health status to demonstrate the public health impact of this nutrient. There is a $65 fee every six months for your sponsorship of this research project, which includes a test kit to be used at home, and electronic reports on your ongoing progress.

You will get a follow up email every six months reminding you “it’s time for your next test and health survey.” By participating in this project, you help move vitamin D research forward so that, hopefully, one day we can end this nonsensical debate about whether vitamin D optimization is worth pursuing or not.

– Sources and References

The cancer fighting benefits of Coenzyme Q10

Reproduced from original article:
www.naturalhealth365.com/benefits-of-coq10-3221.html

by:  

benefits-of-coq10

(NaturalHealth365) Coenzyme Q10, or CoQ10, is a substance found in every cell of our body. It is in a variety of foods, and healthy people are not likely to develop a deficiency of this nutrient. But, you might want to think about taking in some extra CoQ10 – especially if you’re taking a statin to lower your cholesterol levels.

CoQ10 has many potential health benefits, including possibly lowering the risk of certain cancers. Women, especially, should take note, since recent research points to links between breast cancer risk and lower levels of CoQ10 in the blood.

Clearing up the confusion about CoQ10

Coenzyme Q10 is technically not a vitamin because your body can synthesize it, so you do not need to get it from food. However, its structure is similar to that of vitamins. Also like vitamins, it acts as a coenzyme functions in your body’s metabolic reactions.

CoQ10 also has powerful antioxidant properties. For example, it helps prevent harmful oxidation of LDL cholesterol, and it supplements the work of vitamin E, or tocopherol. When your blood levels of CoQ10 are lower, your body needs more vitamin E from the diet to carry out heart-healthy antioxidant reactions.

What are the health benefits associated with CoQ10?

Can a Coenzyme Q10 deficiency increase the risk of cancer?

Since the 1960s, researchers have noted associations between lower blood levels of CoQ10 and cancer. People with lymphoma, myeloma, and lung, head, neck, and prostate cancers tend to have lower levels of CoQ10.

Do NOT ignore the health dangers linked to toxic indoor air.  These chemicals – the ‘off-gassing’ of paints, mattresses, carpets and other home/office building materials – increase your risk of headaches, dementia, heart disease and cancer.

Get the BEST indoor air purification system – at the LOWEST price, exclusively for NaturalHealth365 readers.  I, personally use this system in my home AND office.  Click HERE to order now – before the sale ends.

A recent study looking into links between CoQ10 and breast cancer examined data from nearly 1,000 women aged 40 to 70 in the Shanghai Women’s Health Study. Those who had serum levels of CoQ10 in the bottom fifth of participants had a 90 percent greater chance of being diagnosed with breast cancer than those whose levels were in the middle fifth.

“The current Shanghai Women’s Health Study, with relatively larger sample size and longer follow-up time suggests an inverse association for plasma CoQ10 levels with breast cancer risk in Chinese women,” according to study authors Robert V. Cooney of the University of Hawaii and colleagues. Based on these results, future research should investigate potential effects of supplementation on the risk of breast cancer.

The study also confirmed the association between low CoQ10 and higher risk of cervical cancer, myeloma, and melanoma. This makes the results relevant to men as well as women. This study is far from definitive, but it seems likely that there is a link between healthy CoQ10 levels and reduction in cancer risk.

CoQ10 is in a variety of foods, including meat, fish, and eggs, and organ meats, such as heart, kidney, and liver, are especially rich sources. You can also find CoQ10 in plant-based foods, such as cauliflower, peanuts, soybean oil, and strawberries.

Obviously, you can obtain additional benefits, with ease, by supplementing your diet with a high quality CoQ10 supplement.

Sources for this article include:

Healthline.com
NaturalHealth365.com

Warfarin – The Rat Poison Drug

Written by Brenton Wight – LeanMachine, Health Researcher
Posted 8th December 2017, Updated 4th December 2019.
Copyright © 1999-2019 Brenton Wight and BJ&HJ Wight trading as Lean Machine abn 55293601285

Why use Warfarin?

Warfarin is a blood thinner, belonging to a class of drugs known as anti-coagulants, designed to keep blood thin and prevent clots. They make it hard for clots to form, which is a good thing if we are trying to prevent an ischemic (blood blockage) stroke, but a bad thing if we have a hemorrhagic (bleeding)stroke.
It is the most often prescribed drug prescribed for AF (atrial fibrillation), a type of irregular heartbeat, where upper chambers of the heart quiver instead of contracting efficiently, affecting millions of people.
Although AF is not necessarily life-threatening by itself, it can increase risk of blood clots which can break free to cause an ischemic stroke if the clot lodges in a brain artery, or pulmonary thrombosis if lodged in a lung artery.
However, there are down sides.
– Warfarin makes it difficult to stop a cut from bleeding.
– Warfarin increases risk of a hemmorhagic stroke (bleeding in the brain).
– Warfarin increases risk of intestinal bleeding.
– Warfarin increases risk of an aneurysm where a blood vessel ruptures.
– Warfarin increases risk of uncontrolled bleeding due to a fall or accident.

The Warfarin Study

A new study shows that Warfarin (marketed under the name Coudamin), a heart drug taken by millions of people, increases dementia risk 300%.
This study, led by Dr. T. Jared Bunch, was conducted by the Intermountain Healthcare Clinical Pharmacist Anticoagulation Service, based in Salt Lake City, and examined the medical records of more than 10,000 patients.
Dr Bunch presented the study results at the Heart Rhythm Society’s annual meeting in San Francisco.
The findings were:

  • Patients with erratic warfarin levels have a higher risk of small clots, or small bleeds in the brain, causing dementia
  • AF patients have three times the risk of dementia compared to those who take warfarin for other conditions
  • Some foods, drinks, antibiotics and other drugs alter warfarin blood levels quickly. Regular blood tests and dose variations are essential to maintain the correct range
  • The dementia risk increases to four times higher if the dose is not exactly right or requires frequent adjustment

History of Rat Poison

The University of Wisconsin developed the drug as a rat poison in the 1940’s. It kills rodents by invoking bleeding. Rats bleed to death after ingesting the poison.
Endo Laboratories began selling it for human use in the 1950’s, but Warfarin proved to be a management problem for doctors and patients. Bad reactions to many foods and some drugs, especially antibiotics, are common with Warfarin treatment.

Warfarin Side Effects

Another study by New England Journal of Medicine showed that warfarin accounts for double the emergency hospitalizations than any other drug, and is the leading cause of emergency room visits by seniors.
Apart from dementia, warfarin causes internal bleeding, stomach ulcers, kidney failure, and chronic cough. Hillary Clinton takes warfarin, and has suffered a severe cough while campaigning in 2016.
Of course, given that dementia is a common problem with seniors, and the risk for dementia is three to four times higher, more dementia means more missed or doubled-up doses of Warfarin, sometimes leading to death of the patient.

Prescription Alternatives

There are a few options:

  • Apixaban (Eliquis)
  • Dabigatran (Pradaxa)
  • Edoxaban (Savaysa)
  • Rivaroxaban (Xarelto)

Whichever we use, there is always a risk of bleeding problems.
The new medications have a reduced risk of bleeding, and wear off faster than warfarin, so appear to be safer.
However, dangerous bleeding while taking warfarin can be controlled with Vitamin K, or a combination of PCC (prothrombin complex concentrate) and fresh frozen plasma.
The amount of vitamin K in the diet, contained in leafy green vegetables, determines the effectiveness of Warfarin, so we must consistently eat the same foods. We can eat salads (and we should) but we have to eat them all the time with warfarin. This is not a problem for the new drugs because Vitamin K does not interfere with their operation. If we ate plenty of salads regularly throughout our life, we would probably never need warfarin!
Praxbind (idarucizumab) can be used in emergencies to reverse the anti-clotting effects of Pradaxa.
Other drugs to reverse blood-thinning are still in development.
Xarelto currently (in 2019) has no approved antidote, meaning that an overdose or a bleed from, say, a fall resulting in a nasty bump on the head, could cause death by a brain bleed.
Because Xarelto and others have no really effective antidote, bleeding is difficult to control. Given that many seniors with poor cognitive function are taking these drugs, overdosing is common, and can cause death. A horrifying sight in the emergency room is a patient bleeding from the nose, eyes, fingernails, toenails etc.

Drugs and Lifestyle

The new drugs are more convenient in that they do not require as many blood tests as warfarin, which requires testing at least monthly, after getting the initial dose right, where the starting dose is high, followed by a maintenance dose, and blood tests are required every 2 to 3 days until the levels stabilise.
Apart from the inconvenience of regular blood testing, many people do not like getting stuck with a needle so often.

Interaction with Other Medications

Some prescription drugs, some supplements and some foods interfere with warfarin, while others make warfarin work too well, which can cause a major bleeding problem.
Some seniors have presented at the emergency room with blood coming from all fingernails, toenails, eyes, nose, mouth, etc.
Often the slightest bump in the body results in extensive bruising, and a small cut results in excessive bleeding.
There is an enormous list of medications that interact with warfarin. The newer blood thinners also have interactions, but nowhere near as many.
The new blood thinners have some benefits over warfarin, but if we manage our warfarin well, there is no need to change. However, if we have kidney failure or mechanical heart valves the new medications may not be safe.

Natural Alternatives

Warfarin patients whose dosages often change should ask their doctor for alternative medications, as other blood thinners have fewer potential problems.
Aspirin is another blood-thinning medication given to those with cardiovascular problems, but again, can cause massive problems with internal bleeding, loss of eyesight from Macular Degeneration (bleeding and expansion of blood vessels in the retina), or hemmorhagic stroke (brain bleed).
Natural remedies work well for some people, and here are a few known to work:

These or other natural alternatives may require Warfarin levels to be lowered. Thinning the blood too much while taking Warfarin may be very dangerous.
Green leafy vegetables, high in vitamin K, act as an antidote to warfarin, requiring higher dosage for effectiveness, but a change in diet will cause a higher risk of bleeding.

LeanMachine online supplements

Disclaimer

LeanMachine is not a doctor, and everyone should consult with their own health professional before taking any product to ensure there is no conflict with existing prescription medication.
LeanMachine has been researching nutrition and health since 2011 and has completed many relevant studies including:
Open2Study, Australia – Food, Nutrition and Your Health
RMIT University, Australia – Foundations of Psychology
Swinburne University of Technology, Australia – Chemistry – Building Blocks of the World
University of Washington, USA – Energy, Diet and Weight
Johns Hopkins Bloomberg School of Public Health, USA – Health Issues for Aging Populations
Johns Hopkins Bloomberg School of Public Health, USA – International Nutrition
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics I
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics II
Johns Hopkins Bloomberg School of Public Health, USA – Principles of Human Nutrition
TUFTS University, USA – Nutrition and Medicine
TUFTS University, USA – Lipids/Cardiovascular Disease I and Lipids/Cardiovascular Disease II
Technical Learning College, USA – Western Herbology, Identification, Formulas
Bath University, England – Inside Cancer
WebMD Education – The Link Between Stroke and Atrial Fibrillation
WebMD Education – High Potassium: Causes and Reasons to Treat
Leiden University Medical Center, Netherlands – Anatomy of the Abdomen and Pelvis
MIT (Massachusetts Institute of Technology) – A Clinical Approach to the Human Brain
LeanMachine has now examined thousands of studies, journals and reports related to health and nutrition and this research is ongoing.

Posted 8th December 2017, Updated 4th December 2019. Copyright © 1999-2019 Brenton Wight and BJ & HJ Wight trading as Lean Machine abn 55293601285

8 Juicy Reasons to Eat More Strawberries

© 30th October 2019 GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here www.greenmedinfo.com/greenmed/newsletter
Reproduced from original article:
www.greenmedinfo.health/blog/8-juicy-reasons-eat-more-strawberries

Posted on: Wednesday, October 30th 2019 at 11:00 am

Who doesn’t love strawberries? And you don’t need any reason other than the pleasure of their sweetness to eat them every day. But according to researchers from Oklahoma State University, there’s lots more to strawberries than the flavor.[i]

Their study was published in the journal Critical Reviews in Food Science and Nutrition with funding from the NIH and the California Strawberry Commission. In it the researchers review over 130 studies attesting to the strawberry’s status as a “functional food.”

There is no regulated meaning for the term “functional food.” But it usually refers to a food that provides some benefit in addition to calories that may reduce disease risk or promote general health. That can be said of every fresh, organic whole food. But functional food is also a term that has become a marketing tool for food manufacturers who “enrich” their processed foods with vitamins, minerals, herbs and other supplements.

But strawberries don’t need any enriching. They consistently rank among the top fruits and vegetables for health benefits. They are full of powerful natural compounds that include:

  • Antioxidants – Strawberries were found to have higher oxygen radical absorbance capacity (ORAC) activity than black raspberries, blackberries or red raspberries.[ii] One study even found strawberries have the highest antioxidant capacity of ALL fruits and vegetables commonly available in the UK as measured by the trolox equivalent antioxidant capacity (TEAC) assay.[iii]
  • Polyphenols – Strawberries have been listed among the 100 richest sources of dietary polyphenols.[iv] They contain flavonoids like catechin, epicatechin, quercetinkaempferol, cyanidins, naringenin, hesperadin, pelargonidin, ellagic acid and ellagitannins. Flavonoids are free radical scavengers, and have anti-inflammatory effects. They also dilate blood vessels and slow tumor growth.
  • Vitamins and Minerals – Strawberries are high in vitamin C (ascorbic acid), B vitamins, vitamin E, folate, carotenoids and potassium.
  • Anthocyanins – These are water-soluble compounds responsible for the deep colors of berries and are among the principal bioactives in strawberries.
  • Phytosterols – These plant-derived sterols have structures and functions similar to cholesterol.

All of those natural components translate to a broad range of health benefits. Animal and cell culture studies show strawberries may be effective in reducing risk factors for cardiovascular disease including obesity, hyperglycemiahyperlipidemiahypertension, and oxidative stress.

Here are eight scientifically proven reasons to eat more strawberries:

1. Strawberries Lower Heart Attack Risk

In an analysis of data from over 93,000 subjects in the famous Nurses’ Health Study I and the Nurses’ Health Study II, researchers looked at the effects of eating strawberries and blueberries on cardiovascular health. They found that over a 14-year period, women eating just three servings weekly of blueberries or strawberries reduced their risk of heart attack by 33% compared to those eating berries once monthly or less.[v]

In addition, in an analysis of data from over 34,489 postmenopausal women in the Iowa Women’s Health Study, eating strawberries was associated with a significant reduction in deaths from cardiovascular disease over a 16-year follow-up period.[vi]

2. Strawberries Reduce Hypertension

Researchers again used the data from the two Nurses Studies as well as data from the Health Professionals Follow-Up Study to measure cardiovascular health benefits of strawberry and blueberry anthocyanins. They found that higher intakes of strawberry and blueberry anthocyanins (16-22 mg/day) were associated with a significant 8% reduction in the risk of hypertension. That was compared to those consuming only 5-7 mg/day of berry anthocyanins.[vii]

3. Strawberries Lower Inflammation and C-Reactive Protein (CRP)

In a study of 38,176 female US health professionals enrolled in the Women’s Health Study participants were asked whether they ate fresh, frozen, or canned strawberries “never,” or “less than one serving per month,” or up to “6+ servings per day.” Over an 11-year follow-up period, cardiovascular disease was lower among those consuming more strawberries.

CRP levels were significantly reduced among women consuming just two or more servings of strawberries per week.[viii]Elevated CRP is strongly associated with inflammation and is a high-risk factor for cardiovascular disease.

4. Strawberries Reduce Cancer Risk

In a prospective five-year cohort study in an elderly population, higher consumption of fresh strawberries and other fruits and vegetables was associated with significantly reduced cancer mortality. The authors attribute these observations to the carotenoid content of fruits and vegetables known to exert anti-carcinogenic effects.[ix]

In another larger five-year prospective cohort study, eating more foods from the Rosaceae botanical subgroup, including strawberries, was associated with a protective effect against esophageal squamous cell carcinoma compared to eating less of this fruit group.[x] The same cohort also reported reduced rates of head and neck cancer among those consuming more servings of the Rosaceae botanical subgroup including strawberries.[xi]

Other studies show that strawberries can even reverse early stage esophageal cancer.

5. Strawberries Reduce Oxidized Cholesterol

Studies show strawberries increase plasma antioxidant capacity helping to reduce oxidized LDL cholesterol. In human trials fresh, frozen, or freeze-dried strawberries were shown to reduce oxidative stress associated with metabolic syndrome or eating high-fat meals.[xii]

6. Strawberries Lower LDL Cholesterol and Raise HDL Cholesterol

The fiber, phytosterols, and polyphenols in strawberries have been shown to lower serum total and LDL cholesterol.[xiii] It’s also been shown to raise serum high-density lipoprotein (HDL)-cholesterol.[xiv]

7. Strawberries Help Control Blood Glucose Levels

Polypenols in a berry mixture that included strawberries produced a lower glucose response after eating a meal.[xv]

8. Strawberries May Help Reverse Age-Related Neurodegenerative Disorders

In an animal study researchers at the USDA Human Nutrition Research Center on Aging at Tufts found that strawberry extracts significantly reversed signs of age-related neuronal deficits.[xvi]

And animals eating a diet including 2% strawberries for two months showed significant protection from radiation damage to neurons.[xvii] Researchers suggest that strawberries and other berries may have a role in reversing Alzheimer’s disease or Parkinson’s disease.[xviii]

Are Fresh or Frozen Strawberries Better?

Studies show benefits to all forms of strawberries whether fresh, frozen, dried, pureed, or made into juices or jams. But the more they’re processed the more strawberries can lose some of their active compounds.

Frozen strawberries have significantly higher vitamin C (ascorbic acid) and polyphenols than freeze-dried or air-dried.[xix] Processing strawberries into juices and purees also results in a loss of ascorbic acid, polyphenols, and antioxidant capacity.[xx] And canning strawberries or making them into jams can significantly reduce the levels of anthocyanins and total phenolic compounds.[xxi]

Fresh or frozen are the best choices for health benefits when it comes to strawberries. But processed strawberry products still have some benefits and are a good choice when the real things aren’t in season.

Just remember to buy organic berries. Most conventionally grown strawberries are heavily sprayed with pesticides.

For more studies visit GreenMedInfo’s page on strawberries.

Originally published: 2014-10-07

Article updated: 2019-10-30


References

[i] Arpita Basu , Angel Nguyen , Nancy M. Betts & Timothy J. Lyons “Strawberry As a Functional Food: An Evidence-Based Review.” Critical Reviews in Food Science and Nutrition, (2014) 54:6, 790-806.

[ii] Wang, S. Y., and Lin, H. S. (2000). “Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage.” J. Agric. Food Chem. 48:140-146.

[iii] Proteggente, A. R., Pannala, A. S., Paganga, G., Van Buren, L., Wagner, E., Wiseman, S., Van De Put, F., Dacombe, C., and Rice-Evans, C. A. (2002). The antioxidant activity of regularly consumed fruit and vegetables reflects their phenolic and vitamin c compositionFree Radic. Res. 36:217-233.

[iv] P’erez-Jim’enez, J., Neveu, V., Vos, F., and Scalbert, A. (2010). “Identification of the 100 richest dietary sources of polyphenols: An application of the phenolexplorer database.” Eur. J. Clin. Nutr. 64:S112-S120.

[v] Aedín Cassidy, Kenneth J Mukamal, Lydia Liu, Mary Franz, A Heather Eliassen, Eric B Rimm. High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women. Circulation. 2013 Jan 15 ;127(2):188-96.

[vi] Mink, P. J., Scrafford, C. G., Barraj, L. M.,Harnack, L., Hong, C. P.,Nettleton, J. A., and Jacobs, D. R., Jr. (2007). Flavonoid intake and cardiovascular disease mortality: A prospective study in postmenopausal womenAm. J. Clin. Nutr. 85:895-909.

[vii] Cassidy, A., O’Reilly, E. J., Kay, C., Sampson, L., Franz, M., Forman, J. P., Curhan, G., and Rimm, E. B. (2010). Habitual intake of flavonoid subclasses and incident hypertension in adults. Am. J. Clin. Nutr. 93:338-347.

[viii] Sesso, H. D., Gaziano, J. M., Jenkins, D. J., and Buring, J. E. (2007). Strawberry intake, lipids, c-reactive protein, and the risk of cardiovascular disease in womenJ. Am. Coll. Nutr. 26:303-310.

[ix] Colditz, G. A., Branch, L. G., Lipnick, R. J.,Willett,W. C., Rosner, B., Posner, B. M., and Hennekens, C. H. (1985). Increased green and yellow vegetable intake and lowered cancer deaths in an elderly populationAm. J. Clin. Nutr. 41:32-36.

[x] Freedman, N. D., Park, Y., Subar, A. F., Hollenbeck, A. R., Leitzmann, M. F., Schatzkin, A., and Abnet, C. C. (2007). Fruit and vegetable intake and esophageal cancer in a large prospective cohort studyInt. J. Cancer. 121:2753-2760.

[xi] Freedman, N. D., Park, Y., Subar, A. F., Hollenbeck, A. R., Leitzmann, M. F., Schatzkin, A., and Abnet, C. C. (2008). Fruit and vegetable intake and head and neck cancer risk in a large United States prospective cohort studyInt. J.Cancer. 122:2330-2336.

[xii] Paiva, S. A., Yeum, K. J., Cao, G., Prior, R. L., and Russell, R. M. (1998). Postprandial plasma carotenoid responses following consumption of strawberries, red wine, vitamin c or spinach by elderly womenJ. Nutr. 128:2391-2394.

[xiii] Basu, A., Fu, D. X., Wilkinson, M., Simmons, B., Wu, M., Betts, N. M., Du, M., and Lyons, T. J. (2010). Strawberries decrease atherosclerotic markers in subjects with metabolic syndromeNutr. Res. 30:462-469.

[xiv] Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P.,Mattila, P., and Jula, A. (2008). Favorable effects of berry consumption on platelet function, blood pressure, and hdl cholesterolAm. J. Clin. Nutr. 87:323-331.

[xv] T¨orr¨onen, R., Sarkkinen, E., Tapola, N., Hautaniemi, E.,Kilpi, K., andNiskanen, L. (2010). Berries modify the postprandial plasma glucose response to sucrose in healthy subjectsBr. J. Nutr. 103:1094-1097

[xvi] Joseph, J. A., Shukitt-Hale, B., Denisova, N. A., Prior, R. L., Cao, G., Martin, A., Taglialatela, G., and Bickford, P. C. (1998). Long-term dietary strawberry, spinach, or vitamin e supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficitsJ. Neurosci. 18:8047-8055.

[xvii] Rabin, B. M., Joseph, J. A., and Shukitt-Hale, B. (2005). Effects of age and diet on the heavy particle-induced disruption of operant responding produced by a ground-based model for exposure to cosmic raysBrain Res. 1036:122-129.

[xviii] Joseph, J. A., Shukitt-Hale, B., and Willis, L. M. (2009). Grape juice, berries, and walnuts affect brain aging and behaviorJ. Nutr. 139:1813S-1817S.

[xix] Asami, D. K., Hong,Y. J.,Barrett, D. M., and Mitchell, A. E. (2003).Comparison of the total phenolic and ascorbic acid content of freeze-dried and air-dried marionberry, strawberry, and corn grown using conventional, organic, and sustainable agricultural practicesJ. Agric. Food Chem. 51:1237-1241.

[xx] Klopotek,Y., Otto, K., and B¨ohm,V. (2005). Processing strawberries to different products alters contents of vitamin c, total phenolics, total anthocyanins, and antioxidant capacityJ. Agric. Food Chem. 53:5640-5646.

[xxi] Ngo, T., Wrolstad, R. E., and Zhao, Y. (2007). Color quality of Oregon strawberries-impact of genotype, composition, and processingJ. Food Sci. 72:C025-C032.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.
LeanMachine Note: Strawberries may also be sprayed, so organic is best, and wash before eating.

The Little Known Miracle of Life: Fulvic acid

© 7th November 2019 GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here www.greenmedinfo.com/greenmed/newsletter
Reproduced from original article:
www.greenmedinfo.health/blog/little-known-miracle-life-fulvic-acid

Posted on: Thursday, November 7th 2019 at 12:30 pm

In the beginning, the earth was blessed with rich, fertile soil and lush vegetation. The soil was teaming with microbes — bacteria, fungi, and protozoa, to name a few. In the perfect cycle of life, microbes in the soil break down dead plant material and create substances and nutrients that nourish plants. When humans eat these plants, we enjoy the nutrients that they provide

The microbes in the soil make the hidden treasure called fulvic acid, the miracle of life. Fulvic acid is not a vitamin or a mineral and science cannot synthesize this substance in a laboratory. Our bodies require it for optimal health, but, we no longer get fulvic acid in adequate amounts from our food.

While the scientific research is growing in support of fulvic acid, there are less than 1,750 studies on PubMed.gov. One needs to dig around to find fulvic studies related to human benefits, but information and clinical evidence exists. This is not “just another supplement” but a powerful, life-giving substance that is quietly disappearing from our food and this is taking a toll on human health.

Fulvic acid has been reported to rejuvenate health and bring a multitude of benefits that are unmatched by any other natural substance.

Fulvic acid (FA) has been used for 3,000 years as Shilajit in Indian medicine.

Carrasco-Gallardo stated, “It is likely that the curative properties attributable to shilajit are provided by the significant levels of fulvic acids that shilajit contains, considering that fulvic acid is known by its strong antioxidant actions.” [v]

Historically, it was believed that fulvic acid/Shilajit had immune-modulating, antioxidant, diuretic, antihypertensive, and hypoglycemic benefits. [Winker][Trivadi] FA was used in diabetes, and to support the urinary, immune, digestive, cardiac, and nervous systems. [xxiv][i][ii][viii]

In Ayurveda literature it is called “rasayana” or rejuvenator, enhancing the quality of life. [xxxviii][xv]

Benefits

Fulvic acids can be found in compost or peat, lignite (brown coal which gives inferior fulvic acid) or ancient humic deposits that come from deep within the earth. Unlike other deposits formed over time deep below the earth’s surface, like coal, oil and natural gas, humic deposits are safe, providing powerful compounds that provide an impressive number of benefits for plants, humans and animals.

  • enhances the body’s absorption of vitamins and minerals [xxxix]
  • anti-inflammatory effects [iv][x][xiv][xxxvii][xxxiii]
  • anti-allergy [xl]
  • improves many aspects of eczema [xiv]
  • speeds skin healing [xxix][xiv][xxxvii]
  • enhances healing of wounds infected with drug-resistant pathogens [xliv][xlii]
  • protects against free radical damage as an antioxidant [iv][xxxiv][xxv]
  • anti-aging benefits [v]
  • improves gut flora and gut health [xxxix]
  • anti-diarrheal effects in animals and humans [xxvi]
  • improves energy levels [xxiv]
  • reduces oxidative stress [xxxix]
  • useful in treatment of osteoarthritis patients [xix]
  • shows antiviral activity, interfering with a virus’ ability to attach to a host cell, penetrate the host cell, and reproduce itself [xxii][xxviii]
  • displays antimicrobial activity [xxxvi]
  • displays antifungal activity [xiii][xxxii]
  • effective for the management of oral biofilm infections [xxxiii]
  • anti-aging effect on the skin, increasing fibroblast viability and reducing collagen degradation [xxi]
  • neuroprotective, improves memory and brain function [v][ix][xvi]
  • supports the immune system [xxxix]
  • stimulates metabolism [vi]
  • cleanses toxins and heavy metals from the body [xviii][vii][xxiii]
  • shows immunomodulatory activity [xxxi]
  • modulates homocysteine and pro-inflammatory mediators linked to atherosclerosis [xii]
  • promotes ulcer healing [xv][xxxi][xli]

Science cannot create fulvic acid

Fulvic acid offers a seemingly endless spectrum of benefits for human and animal health that would make any pharmaceutical company nervous. Fulvic acid cannot be made by man because it involves photosynthesis and humification. The process that creates fulvic acid requires nature’s recyclers, microorganisms, working in fertile, rich soil over a long period of time. Microbes decompose organic material (manure, compost, decaying plant material), in the soil to create nutrients for the plant including trace minerals, carbon, hydrogen, oxygen, nitrogen, phosphorus, and potassium. Microbes make the minerals in the soil into a useful form for plants and over time the microbes help create an amazing substance called humus (hyoo-muh s).

“Essentially, All Life Depends Upon The Soil … There Can Be No Life Without Soil And No Soil Without Life”

~ Charles E. Kellogg, head of the Soil Survey in the United States Department of Agriculture (USDA) for 37 years (1934-1971)

We never had to worry about getting enough fulvic acid, it simply existed in our soil and in our food, since time began. Fertile soil, and the microbial life within it, is a highly valuable natural resource that is critical for food security and for human health. Fertile soil is teaming with microbial life (it is interesting to note that there are more bacteria in two spoonfuls of rich, fertile soil than there are humans on planet earth). Sustainable farming practices that add compost and organic compounds to the soil help create a robust microbial community. Microbes are required for the cycle of life. They work to break down plant and animal matter, and over hundreds and thousands of years, fulvic acid is one of the end products of decomposition.

Common agricultural practices cause the loss of fulvic acid in food and the progressive deterioration of human health

Over the past 50 to 100 years, farming practices that sustained humans for thousands of years have drastically changed. Chemical fertilizers, herbicides and pesticides were created to increase crop yield, kill insects and control weeds. Modern agricultural practices increase the amount of food produced but the toll this has taken on soil microbes, plant nutrients and human and animal health is underappreciated.

While attempting to kill the pests and weeds and bolster plant production, the chemicals used in agriculture have inadvertently attacked friendly troops in the soil jungle.

The price of growing food this way is dramatically altering the natural recycling process required in nature, and the downstream effects on human health are mounting.

Fulvic acid may seem like “just another nutrient” that is declining in food, but it is actually the most important health-building compound because it is nature’s intended vehicle for transporting minerals and other nutrients into living cells.

Fulvic acid is nature’s answer to depleted food and too many toxins

Fulvic acid and humic acid are the key substances found in humus, the end result of the humification process where microbes in the soil break down once living matter, usually plants. It is believed that most of the health benefits attributed to Shilajit and humic substances are primarily due to the presence of fulvic acid. [v]

Fulvic acid is a very small molecule of low molecular weight. It is smaller than humic acid and penetrates the cell membrane and even the mitochondria. [v] Because fulvic acid bonds easily to nutrients like vitamins and minerals, it efficiently delivers nutrients where they are needed. Without fulvic acid our bodies’ ability to absorb nutrients (from food or supplementation) is diminished. [xxiv]

Fulvic acid’s small molecular weight coupled with the fact that it is water soluble at all pH levels, makes it superior for working in the body to:

  • deliver nutrients
  • bring antioxidant benefits
  • remove cellular waste products and toxins [xliii]

“You can trace every sickness, every disease and every ailment to a mineral deficiency.”

~Dr. Linus Pauling, awarded two Nobel Prizes

It is well known that minerals are required for a range of biochemical processes, but mineral deficiencies are epidemic. Our food lacks the vitamin and mineral content that it should have and most supplements do not absorb well enough to correct mineral deficiencies. The fulvic acid complex contains bioavailable minerals and trace elements that are desperately needed to combat widespread mineral deficiency in humans.

Fulvic acid is nature’s answer to the problem that man has created with over-farming and the production of processed foods.

Fulvic acid is a magical vehicle with 60 seats

The main components of fulvic acid are carbon, hydrogen and oxygen. These molecules in fulvic acid easily bond to other molecules and transport them through the body. It can possess over 70 trace elements, electrolytes, polyphenols, flavonoids, and essential amino acids.

Naturopathic physician, Dr. Daniel Nuzum, has been studying fulvic acid since 1998. He has used fulvic acid supplements with thousands of patients, and he researches and teaches extensively about fulvic acid. Very few doctors can make this claim, and have little to no experience with fulvic acid. Dr. Nuzum is an expert and he is able to communicate a difficult concept in a way that is easy to understand. “Fulvic acts like the FedEx truck and the garbage truck,” Dr. Nuzum explained. “It delivers nutrition into the cell and carries the trash (toxins & waste) out too!”

Fulvic acid has 60 receptor sites and because it is a carbon-based compound, it bonds easily to nutrients. Dr. Nuzum likens fulvic acid to a 60-passenger bus carrying nutrients in each of the 60 seats. The fulvic acid bus travels along to cells needing a nutrient package delivered. When it drops off the nutrient package, a seat is empty on the fulvic acid bus, so it picks up cellular waste and toxins, like the garbage man, and removes them from your system.

The missing puzzle piece

Many people are feeling the effects of low nutrient absorption, even in the presence of a good diet with regular intake of supplemental vitamins and minerals. This information about fulvic acid is the missing puzzle piece for many people seeking health. Whether you are fighting an infection, rebuilding health, or desire anti-aging strategies, add fulvic acid daily to help your body absorb and use needed nutrients. Take advantage of this powerful electrolyte and antioxidant.

Increase cellular voltage to increase health and energy

Fulvic acid has highly active carbon, hydrogen, molecular oxygen (available oxygen) and enables better electrolyte balance. It recharges cells allowing them to carry an electrical charge longer than normal and survive longer as a cell.

Your body must get enough electrons to keep cells at a healthy, healing voltage. While proper nutrition is a critical piece, it is not enough without voltage. This is where fulvic acid comes in to help. Fulvic acid brings molecular oxygen into the body, increasing the oxygen concentration.

CareyLyn Carter, biochemist and researcher said in an interview, “Fulvic acid molecules act like mini-batteries, going around and charging everything that it comes in contact with. It raises the voltage. When our cell’s membranes are fully charged, nutrients can get inside the cell more easily. When nutrients are inside cells they are available for biochemical processes that support our wellness.”

A closer look at fulvic acid for skin conditions, cancer and brain health

Fulvic acid improves skin conditions

Fulvic acid has anti-inflammatory properties.

A randomized, double blind, controlled study showed that fulvic acid significantly improves inflammatory skin conditions, like eczema with topical use, twice daily. It has been shown to be a safe and effective treatment for skin infections, and would be useful for humans and animals. [xiv]

It was found that fulvic acid reduces the pH of the skin, relieves the itch and improves the appearance of the skin rash. [xiv] FA relieves inflammatory skin conditions. [xxxvii]

Fulvic acid has antimicrobial properties and is a safe and effective topical treatment for skin infections. [xxxvi] Previously studies were cited supporting the use of fulvic acid and humic substances for wounds, rashes and fungal infections.

Fulvic acid has anti-cancer actions

Fulvic acid and the humic compounds are potential cancer chemopreventive agents [xxvii] and have been shown to induce cancer cell apoptosis. [xx]

Fulvic acid and humic substances have actions that combat certain cancer risk factors:

  • free radicals (fulvic acid acts as an antioxidant) [v][xliii][xxx]
  • toxins and heavy metals (fulvic acid bonds to and removes toxins and heavy metals) [xviii][vii][xxiii]
  • UV Radiation (fulvic acid is a photoprotective agent) [xxiv]
  • diabetes (humic substances showed hypoglycemic effects in animal studies) [xxxv]
  • inflammation (Winkler and Ghosh stated in a 2018 review study “there is substantial evidence to pursue FvA (fulvic acid) research in preventing chronic inflammatory diseases, including diabetes.”) [xxxix]

Huang showed that fulvic acid suppresses resistin. High levels of serum resistin are associated with several types of cancer and is thought to play a role in the development of colorectal cancer (CRC) by initiating the adhesion of colorectal cancer cells to the endothelium. FA inhibits the adhesion of CRC activated by resistin.[xvii]

Fulvic acid is neuroprotective and gives brain benefits

The Journal of Alzheimer’s Disease, published a study in 2011 that concluded, fulvic acid “has several nutraceutical properties with potential activity to protect cognitive impairment.” Researchers showed evidence that fulvic acid inhibited the formation of intracellular tangles of tau protein, seen in Alzheimer’s disease. [ix]

How to supplement with fulvic acid

Natural sources of fulvic acid

As discussed, conventional food production methods are destroying microbes in the soil, therefore it is imperative to eat the highest quality, organically grown food possible to increase the fulvic acid content and nutrient content of the food.

Organic vegetables

It is possible to get fulvic acid from plants, provided that they have been grown organically, in fertile soil, rich in humic substances. As you know from the earlier discussion on current agricultural practices, this is very difficult to find these days so most people benefit from taking fulvic acid as a supplement.

The best organic vegetables, in terms of fulvic acid, are the root vegetables like radishes, carrots and beets, but there is no way to know for sure that you are getting adequate fulvic acid from your diet.

Organic unsulphured blackstrap molasses from sugar cane

Another source of fulvic acid is organic unsulphured blackstrap molasses from sugar cane. This sweetener provides a good source of minerals and fulvic acid to aid in mineral absorption.

Fulvic acid supplementation

If you are taking any medication, please consult with your healthcare provider for contraindications. While fulvic acid is safe, there just are not enough studies on using fulvic acid with medication.

Take fulvic acid daily as part of your health rejuvenation regimen.

As fulvic acid supplements are being added to the market in a variety of forms, the consumer must be aware that not all fulvic acid supplements are equally safe. Fulvic acid is available in liquid preparations or powder supplements and capsules. It is believed that liquid forms are more bioavailable.

Here are a few things to consider when looking for a fulvic acid supplement:

  • Source. It is important to know that the fulvic acid was not obtained from brown coal (lignite) or deposits from a source contaminated with heavy metals like aluminumleadmercury and arsenic. Look for a product sourced from high quality humic shale.
  • Extraction. Look for fulvic acid extracted with pure, distilled water (not tap water) and no harsh solvents.
  • Water. Tap water containing chlorine and fluoride must never mix with fulvic acid or any of nature’s nutrients as harmful compounds can form. Find out if your fulvic acid provider uses tap water in their supplement preparation.
  • Potency. Will the supplier provide lab-verified data about their potency.
  • Preservative-free, ideally.
  • Glass packaging. Using any type of plastic in the extraction or bottling of fulvic acid is dangerous because the fulvic acid breaks plastic down. Plastic is a petroleum-based substance and will contaminate fulvic acid solutions.

Fulvic acid is a natural, water soluble substance that can be combined with liquids for oral consumption and it can be used topically. Follow directions from the manufacturer of the product you choose, and consider different options for use:

  • Combine fulvic acid with other plant compounds, like spirulina in water, to enhance the benefits.
  • Add fulvic acid to a smoothie or antioxidant superfood supplement drink.
  • Take fulvic acid with herbs, medicinal mushrooms or essential oils suitable for internal consumption.
  • Topically, use fulvic acid in a natural healing salve recipe including plant extracts known to support the skin’s healing.

Should you add fulvic acid to your daily health regimen?

The choice is yours. I believe that we need to supplement with fulvic acid now in order to harness the ability to get more nutrient absorption, increased detoxification, and increased electrical potential.

This may be the missing puzzle piece and help explain the dramatic increase in chronic disease that people of all ages are experiencing. The information on fulvic acid resonated with me the first time I began hearing about it. When that happens, I cannot keep silent – for who knows whether you and I have come to this information for such a time as this.

Originally published: 2019-11-06

Article updated: 2019-11-07

Trans Fats Linked to Increased Risk for Alzheimer’s


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2019/11/07/trans-fats-and-alzheimers.aspx

Analysis by Dr. Joseph MercolaFact Checked

STORY AT-A-GLANCE

  • Three dietary components shown to promote dementia and Alzheimer’s disease are sugar (especially processed fructose), grains and trans fats
  • Research published in the October 2019 issue of Neurology found a strong link between trans fat consumption and incidence of dementia and its various subtypes, including Alzheimer’s disease
  • People in the highest quartile of trans fat levels were 74% more likely to develop dementia. Those in the second-highest quartile had a 52% higher risk
  • Diets rich in carbohydrates are associated with an 89% increased risk for dementia while diets high in healthy fats are associated with a 44% reduced risk
  • Up to half of all Alzheimer’s cases could also be prevented by addressing other modifiable lifestyle contributors such as physical inactivity, depression, smoking, high blood pressure, midlife obesity and diabetes

As noted by neurologist Dr. David Perlmutter, author of “Grain Brain” and “Brain Maker,” your diet and other lifestyle factors have major implications for your Alzheimer’s risk.

Indeed, according to research1,2 published in the journal Lancet Neurology in 2011, up to half of all Alzheimer’s cases could be prevented by addressing modifiable lifestyle contributors such as physical inactivity, depressionsmokinghigh blood pressure, midlife obesity and diabetes.

Three dietary components shown to promote this neurological degeneration are sugar (especially processed fructose), grains and trans fats. Research3,4 from the Mayo Clinic, published in the Journal of Alzheimer’s Disease in 2012, found diets rich in carbohydrates are associated with an 89% increased risk for dementia while diets high in healthy fats are associated with a 44% reduced risk.

As noted by the authors,5 “A dietary pattern with relatively high caloric intake from carbohydrates and low caloric intake from fat and proteins may increase the risk of MCI [mild cognitive impairment] or dementia in elderly persons.” Similarly, a 2013 study6 in the journal BioMed Research International reported that:

“Increasing epidemiological studies suggest that diet and nutrition might be important modifiable risk factors for AD [Alzheimer’s disease].

Dietary supplementation of antioxidants, B vitamins, polyphenols, and polyunsaturated fatty acids are beneficial to AD, and consumptions of fish, fruits, vegetables, coffee, and light-to-moderate alcohol reduce the risk of AD … Adherence to a healthy diet, the Japanese diet, and the Mediterranean diet is associated with a lower risk of AD.”

Trans Fat Consumption Increases Your Dementia Risk

Most recently, research7 published in the October 2019 issue of Neurology found a strong link between trans fat consumption and incidence of dementia and its various subtypes, which includes Alzheimer’s disease (AD).

The study included 1,628 Japanese seniors aged 60 and older. None had dementia at the outset of the study, which went on for 10 years. Levels of elaidic acid — a biomarker for industrial trans fat — in the participants’ blood were measured using gas chromatography/mass spectrometry.

Based on those levels, the hazard ratios for all-cause dementia, AD and vascular dementia were calculated using the Cox proportional hazards model. As reported by the authors:8

“Higher serum elaidic acid levels were significantly associated with greater risk of developing all-cause dementia and AD after adjustment for traditional risk factors. These associations remained significant after adjustment for dietary factors, including total energy intake and intakes of saturated and polyunsaturated fatty acids.”

This increase in risk was not slight. As reported by CNN,9 people in the highest quartile of elaidic acid levels were 74% more likely to develop dementia. Those in the second-highest quartile had a 52% higher risk. No association between trans fat and vascular dementia was found.

Of the various processed foods found to contribute to elevated elaidic acid levels, pastries were the biggest contributors, followed by margarine, candy, caramels, croissants, nondairy creamers, ice cream and rice cakes.10

Dr. Richard Isaacson, a neurologist and director of the Alzheimer’s Prevention Clinic at Weill Cornell Medicine in New York, who was not involved in the study, commented on the findings to CNN:11

“The study used blood marker levels of trans fats, rather than more traditionally used dietary questionnaires, which increases the scientific validity of the results. This study is important as it builds upon prior evidence that dietary intake of trans fats can increase risk of Alzheimer’s dementia.”

Advertisement

Get Up to 38% Off on Vtamin K2 and Vitamins D3 & K2


What Is Trans Fat?

As explained by CNN:12

“… artificial trans fats are created by an industrialized process that adds hydrogen to liquid vegetable oils to make them more solid (think of semi-soft margarine and shortening).

The food industry loves trans fats because they are cheap to produce, last a long time and give foods a great taste and texture. Besides fried foods, trans fats are found in coffee creamer, cakes, pie crusts, frozen pizza, cookies, crackers, biscuits and dozens of other processed foods.”

Trans fats are different from an unsaturated fat by a single hydrogen molecule on the opposite side of a carbon bond.13 This one positional change is responsible for the difference in characteristics of the fat, and the increased danger to your health.

Aside from dementia, strong evidence also links trans fats with inflammation and the development of insulin resistance and heart disease (all of which also happen to be risk factors for Alzheimer’s).

Faced with overwhelming evidence of harm, the U.S. Food and Drug Administration removed partially hydrogenated oils (a primary source of trans fat) from the list of “generally recognized as safe” (GRAS) list of food ingredients in 2015, and as of June 18, 2019, food manufacturers are no longer allowed to use partially hydrogenated oils in foods14 due to their health risks.

Processed foods manufactured before this date, however, are allowed to remain on the market until January 1, 2021.15 (Compliance dates vary depending on whether manufacturers had “limited use” permissions for partially hydrogenated oils, but these are the final dates where all use must cease.)

However, that doesn’t mean that trans fats have been entirely eliminated and are of no further concern. What’s more, as long as a food contains less than 0.5 grams of trans fat per serving, food manufacturers are allowed to label it as trans fat free.

The problem with this is that many experts agree there is no safe threshold below which trans fats are safe.16 To determine whether a product might still contain trans fats, carefully read the ingredients list.

Any item containing partially hydrogenated vegetable oil is bound to contain trans fat, even if the label says “0 Trans Fat.” Fried food and baked goods in general are also suspect.17,18 As lead study author Dr. Toshiharu Ninomiya, a professor at Kyushu University in Fukuoka, Japan, noted in a press release:19

“In the United States, the small amounts still allowed in foods can really add up if people eat multiple servings of these foods, and trans fats are still allowed in many other countries.”

Trans Fat Has Killed Millions

The rise of trans fat can be directly attributed to the wrongful vilification of saturated fats and cholesterol. We now have decades’ worth of data showing saturated fat and dietary cholesterol have no impact on heart disease and mortality. Meanwhile, studies have revealed the switch from saturated fat to trans fat-rich partially hydrogenated vegetable oils have led to the premature death of millions.

When New York severely limited the amount of trans fat allowed to be served at restaurants, it offered a unique opportunity for researchers to study20 the effects on residents and compare rates of heart attack and stroke before and after the restriction.

Three or more years after the restrictions were imposed on specific counties in New York City, researchers found a 6.2% reduction in heart attacks and stroke in those counties compared to areas of the city where the restrictions on trans fat were not imposed.

Considering trans fat has proliferated in the American diet since the late 1950s, the unnecessary death toll attributable to trans fat likely numbers in the millions each year, nationwide. Similar findings have been reported by Danish researchers. Denmark was the first country to act on research demonstrating the dangerous health effects of trans fat.

The study,21 published in 2016, found that in the three years after trans fats were regulated, which nearly eliminated it from the Danish food supply, the annual mean death toll from cardiovascular disease was reduced by an average of 14.2 deaths per 100,000 people per year.

We’ve Known Trans Fat Takes a Toll on Cognition for Years

One can only guess how many people have lost their minds thanks to trans fat over these past decades. The 2019 Neurology study certainly wasn’t the first to demonstrate a clear link between trans fat consumption and dementia risk.

For example, in a 2012 study,22 Dr. Gene Bowman, assistant professor of neurology at Oregon Health and Science University, reported a strong correlation between trans fat and cognitive performance.

People with high levels of trans fat in their blood performed significantly worse in cognitive testing and had reduced brain volume. Bowman commented on the results to HuffPost:23

“It’s clear that trans fats are bad — both for your heart and now, we see, for your brain. So I would recommend that people stay away from all trans fats.

If you aren’t sure whether something has them, just look at the ingredients … if there’s vegetable shortening, partially hydrogenated anything … just put it down. That’s the big message here.”

Similarly, a 2015 study24 led by Dr. Beatrice Golomb found trans fat intake was linked to memory impairment in people under the age of 45. Each gram of trans fat consumed per day was linked to a 0.76 word decrease in word recall.

In the highest trans fat group, participants could recall on average 11 fewer words than those with the lowest trans fat intake, who had an average word recall of 86 words. The research, while unable to establish cause and effect, suggests trans fats may act as a pro-oxidant, contributing to oxidative stress that causes cellular damage.

Oxidized Omega-6 — Another Harmful Fat to Beware Of

It is clearly important to avoid trans fat, but as you will find out next year in an interview I am doing with Dr. Chris Knobbe about his Ancestral Health Symposium presentation, it is processed oils that are the primary culprit for nearly all Western diseases. Assiduously avoiding them is the key to staying healthy.

This is largely related to the oxidized omega-6 fat found in many processed foods, which may actually be even worse than trans fat. Now, omega-6 fat (linolenic acid) in and of itself is not the problem. Linoleic acid is also found in foods such as nuts, seeds and eggs, and is important for health.

The problem is oxidized omega-6 fat, and the fact that most people eat far too much of it. Intakes of omega 6 fat more than century ago were typically below 5 to 10 grams a day, and most of us now eat FAR more than that. For years, I’ve stressed the importance of balancing your omega-3 to omega-6 intake to protect your health.

Eating too much damaged omega-6 fat (found in abundance in processed vegetable oils) and too little marine-based omega-3 sets the stage not just for Alzheimer’s but also for diabetes, cardiovascular disease, rheumatoid arthritis, cancer and depression — and that’s the short list.

It is very easy to overeat omega-6 fats. I recently switched from macadamia nuts to pecans, which are also low in carbs and protein, but I did not realize pecans are loaded with omega-6 fats, relative to macadamia nuts. I only discovered this by using the terrific nutrient tracker Cronometer.com. I have since realized that is not wise to eat more than a handful of nuts and not every day.

I discuss some of the most significant hazards of omega-6-rich vegetable oils in “This Fat Is Actually Worse Than Trans Fat.”

The ideal ratio of omega-3 to omega-6 fats ranges from 1-to-1 to 1-to-5, but the typical Western diet tends to be between 1-to-20 and 1-to-50. Most people, especially Americans, are guilty of this lopsided omega-3 to omega-6 ratio, and to correct it, you typically need to do two things:

1.Significantly decrease intake of damaged omega-6 by avoiding processed foods and foods cooked in vegetable oil at high temperatures. A number of studies25,26 have found that people who regularly eat deep-fried foods have a significantly increased risk of stroke and death.

Common sources of harmful omega-6 to avoid include corn oil, canola oil, soy oil, hydrogenated or partially hydrogenated fats, margarine and shortening.

2.Increase your intake of animal-based omega-3 fats. Ideal sources include small fatty fish such as sardines, anchovies and herring, along with wild-caught Alaskan salmon, or a supplement such as krill oil.

Examples of Healthy Fats to Eat More Of

When it comes to dietary fats, remember this simple ground rule: Natural is best. The tips that follow can help ensure you’re eating the right fats for your health:

Use organic butter (preferably made from organic grass fed raw milk) instead of margarines and vegetable oil spreads — Butter is a healthy whole food that has received an unwarranted bad rap.

Ghee is even better, as you remove the milk solids that many have problems with. Ghee is pure fat with no carbs and is what I personally use. The best way to make it is to place it in a glass container in a dehydrator and don’t heat it higher than 100 degrees F. to preserve the quality.

You can suck off the milk solids with a glass baster. Once you have the ghee you don’t even need to refrigerate it as it is stable at room temperature for many weeks.

Use organic pastured pork lard for cooking and baking — A 2015 analysis27 of more than 1,000 raw foods ranked raw separated pork fat, also known as pork lard, as the eighth healthiest food on a list of 100.28 Valuable nutrients found in lard include:

Vitamin D29

Omega-3 fats30

Monounsaturated fats31 (the same fats found in avocados and olive oil32)

Saturated fats33

Choline34

Coconut oil is another excellent cooking oil that is loaded with health benefits.

To round out your healthy fat intake, be sure to eat raw fats, such as those from avocados, raw nuts, raw dairy products and olive oil. Also increase your animal-based omega-3 fat intake by eating more sardines, anchovies, mackerel, herring or wild-caught Alaskan salmon, or take a supplement such as krill oil.

Following my nutrition plan will automatically reduce your modified fat intake, as it will teach you to focus on healthy whole foods instead of processed junk food. You can also learn more in my interview with Dr. Cate Shanahan, author of “Deep Nutrition: Why Your Genes Need Traditional Food.”

In it, she delves deep into the pros and cons of various fats. The following chart was also created by her, which gives you a quick overview of the good, the bad and the ugly.

good fats oils- versus bad

Eating Right Can Help Prevent Dementia

In closing, remember that, by and large, it is your everyday lifestyle choices that will determine whether your brain will maintain its function throughout your lifetime, or degenerate with age into a potentially deadly neurological disease like Alzheimer’s.

With regard to diet specifically, key factors that will promote lifelong brain health include the following. For a list that also includes other suggested lifestyle modifications, see “How Excess Iron Raises Your Risk for Alzheimer’s.”

Eat real food, ideally organic — Avoid processed foods of all kinds, as they contain a number of ingredients harmful to your brain, including refined sugar, processed fructose, grains (particularly gluten), vegetable oils, trans fats, genetically engineered ingredients and pesticides.

Ideally, keep your added sugar to a minimum and your total fructose below 25 grams per day, or as low as 15 grams per day if you already have insulin/leptin resistance or any related disorders.

Opting for organic produce will help you avoid synthetic pesticides and herbicides. Most will also benefit from a gluten-free diet, as gluten makes your gut more permeable, which allows proteins to get into your bloodstream where they sensitize your immune system and promote inflammation and autoimmunity, both of which play a role in the development of Alzheimer’s.

Replace refined carbs with healthy fats — It’s important to realize that your brain actually does not need carbs and sugars; healthy fats such as saturated animal fats and animal-based omega-3 are far more critical for optimal brain function.

A cyclical ketogenic diet has the double advantage of both improving your insulin sensitivity and lowering your Alzheimer’s risk. When your body burns fat as its primary fuel, ketones are created, which not only burn very efficiently and are a superior fuel for your brain, but also generate fewer reactive oxygen species and less free radical damage.

Pay close attention to the kinds of fats you eat — avoid all trans fats or hydrogenated fats that have been modified in such a way to extend their shelf life. This includes margarine, vegetable oils and various butter-like spreads. For examples of healthy fats to add to your diet, see the section above.

Time-restricted eating in a six- to eight-hour window — Intermittent fasting is a powerful tool to jump-start your body into remembering how to burn fat and repair the insulin/leptin resistance that is a primary contributing factor for Alzheimer’s.
Keep your fasting insulin levels below 3 — If your insulin is high, you’re likely consuming too much sugar and need to cut back.
Optimize your omega-3 level — High intake of the omega-3 fats EPA and DHA help prevent cell damage caused by Alzheimer’s disease, thereby slowing its progression and lowering your risk of developing the disorder.

Ideally, get an omega-3 index test done once a year to make sure you’re in a healthy range. Your omega-3 index should be above 8% and your omega 6-to-3 ratio between 1-to-1 to 5-to-1.

Optimize your vitamin D level — Sufficient vitamin D is imperative for proper functioning of your immune system to combat inflammation associated with Alzheimer’s and, indeed, research shows people living in northern latitudes have higher rates of death from dementia and Alzheimer’s than those living in sunnier areas, suggesting vitamin D and/or sun exposure are important factors.

If you are unable to get sufficient amounts of sun exposure, take daily supplemental vitamin D3 to reach and maintain a blood level of 60 to 80 ng/mL. That said, it’s important to recognize that sun exposure is important for reasons unrelated to vitamin D.

Your brain responds to the near-infrared light in sunlight in a process called photobiomodulation. Research shows near-infrared stimulation of the brain boosts cognition and reduces symptoms of Alzheimer’s, including more advanced stages of the disease.

Delivering near-infrared light to the compromised mitochondria synthesizes gene transcription factors that trigger cellular repair, and your brain is one of the most mitochondrial-dense organs in your body.

Optimize your magnesium levels — Preliminary research strongly suggests a decrease in Alzheimer symptoms with increased levels of magnesium in the brain. Keep in mind that the only magnesium supplement that appears to be able to cross the blood-brain barrier is magnesium threonate.
Vitamin B12 — According to a 2010 study published in the journal Neurology,35,36 people who consume foods rich in B12 may reduce their risk of Alzheimer’s in their later years. Very high doses of B vitamins have also been found to reduce memory loss by preventing brain shrinkage.37
Eat plenty of nitrate-rich foods — Beets and other nitrate-rich foods such as arugula provide powerful benefits for your brain and may be a powerful ally in the fight against Alzheimer’s disease.38

Your body transforms plant-based nitrates into nitric oxide,39 which enhances oxygenation, has beneficial impacts on your circulatory and immune systems, and serves as a signaling or messenger molecule in every cell of your body.

The betanin in beets also helps prevent oxidation, particularly oxidation caused when the beta-amyloid is bound to copper, which may help prevent the misfolding and aggregation of amyloid beta.40

Previous research41 has also shown raw beet juice helps improve neuroplasticity, primarily by increasing blood flow and tissue oxygenation. Nitric oxide, in its capacity as a signaling molecule, allows your brain cells to communicate with each other better. Importantly, the beets boosted oxygenation of the somatomotor cortex, a brain area that is often affected in the early stages of dementia.

Optimize your gut flora — To do this, avoid processed foods, antibiotics and antibacterial products, fluoridated and chlorinated water, and be sure to eat traditionally fermented and cultured foods, along with a high-quality probiotic if needed.

Remember that eating factory farmed meats will provide you with traces of antibiotics in each bite. Factory farmed meats are also a suspected route of prions, which are yet another culprit in Alzheimer’s. You can learn more about this in “Study Claims Alzheimer’s Disease Is a Double-Prion Disorder.”

Novel Treatments Are Being Explored

Diagnostic guidance and core treatment strategies are detailed in my interview with Dr. Dale Bredesen, featured in “ReCODE: The Reversal of Cognitive Decline.” (You can also download Bredesen’s full-text case paper,42 which details his ReCODE treatment program.)

On a side note, two promising treatment alternatives for Alzheimer’s include photobiomodulation, discussed in “Healing the Body With Photobiomodulation,” and a novel treatment developed at MIT using flickering lights and low frequency sound to stimulate gamma frequencies in the brain,43 which appears to reduce plaque formation.44

MIT neuroscientist Li-Huei Tsai discussed the experiments at a recent Society for Neuroscience meeting, saying the therapy appears to improve survival and health of neurons, improving neuronal connectivity and dilating blood vessels in the brain. His team is now investigating whether it might in fact slow Alzheimer’s disease in humans.45

Over the years, as more and more drug trials have failed to find an answer to Alzheimer’s, researchers are increasingly starting to realize that to be able to address this disease with any measure of success, we have to go back to basics.

There’s a wealth of data showing diet and lifestyle factors are where it’s at when it comes to Alzheimer’s prevention and treatment, and this puts the power right into your own hands. There’s a lot you can do to minimize your risk, and cleaning up your diet is the best place to start.

– Sources and References

Do we need vaccinations?

By LeanMachine, including some content by Dr. Mercola, edited and added to by LeanMachine, Health Researcher.

First, let me make this clear: LeanMachine is not anti-vaccine.
True, I have not had a vaccination in around 10 years prior to writing this article, and probably never will. There are some vaccines which can help in some situations for some people, while others can be dangerous or deadly.
However, everyone has the right to full disclosure of the risks versus benefits of anything they allow into their body. We cannot tolerate being lied to about these risks and benefits, and lies from the Drug Industy is becoming normal in our modern world to protect their enormous profits.
We all have a choice of what food we eat, but it seems as time goes on, we are dictated to by Governments, operating on advice from money-driven drug companies, what is injected into us.
We usually do not have a choice in refusing vaccinations. If we refuse such injections, it can deny us the right to the job we want, or the school we can go to. We cannot even sue the drug companies or doctors in the USA as Government legislation protects them when they make us sick or even kill us.
When the Government takes away our right to decide what goes into our bodies, the Government owns us, as they own real estate, cash and cattle. In a “free” society, this cannot be tolerated.
And there are ZERO follow-ups after vaccinations to determine what effect vaccinations have on our general health.

The Nuremberg Code

Vaccinations are technically illegal in Australia.
Australia is a signatory to the Nuremberg Code, which was developed before, during and after the Second World War, when Nazi doctors were using humans as guinea-pigs for all sorts of bizarre experiments without the consent of the subject.
The code states:

  1. Required is the voluntary, well-informed, understanding consent of the human subject in a full legal capacity.
  2. The experiment should aim at positive results for society that cannot be procured in some other way.
  3. It should be based on previous knowledge (e.g., an expectation derived from animal experiments) that justifies the experiment.
  4. The experiment should be set up in a way that avoids unnecessary physical and mental suffering and injuries.
  5. It should not be conducted when there is any reason to believe that it implies a risk of death or disabling injury.
  6. The risks of the experiment should be in proportion to (that is, not exceed) the expected humanitarian benefits.
  7. Preparations and facilities must be provided that adequately protect the subjects against the experiment’s risks.
  8. The staff who conduct or take part in the experiment must be fully trained and scientifically qualified.
  9. The human subjects must be free to immediately quit the experiment at any point when they feel physically or mentally unable to go on.
  10. Likewise, the medical staff must stop the experiment at any point when they observe that continuation would be dangerous.

Of course, ALL vaccinations are in violation of this code. There has been no vaccination produced in decades where a large, double-blind, placebo-controlled independent study has been carried out scientifically to prove the benefit and seek possible side-effects.
Governments who legislate that the refusal of a vaccination means no job, no unemployement benefit, no school, no child care, etc, are in direct violation of the code.
Many vaccinations have killed or maimed for life, many innocent babies, children and adults.

The Australian Vaccine Schedule

The link below points to the vaccination schedule in 2017. Doctors, hospitals, nurses and others are obliged to carry out vaccinations according to the schedule.
Australian Government Vaccine Schedule
Problems with this schedule:
At birth, babies must be given a Hepatitis B vaccination, but why?
We can get Hepatitis B from a dirty needle when using street drugs, or having casual, unprotected sex with multiple partners of unknown health.
How many babies, just hours old, fit this criteria?
Any why give a baby, with an underdeveloped immune system, a toxic injection?
This is outrageous and criminal, and parents must refuse, before the birth, as this often happens without the knowledge or the consent of the parents, or the baby!

Lies from the CDC (Centers for Disease Control and Prevention)

The CDC in the USA is supposed to protect us from disease, or so you may think. Australia generally uses the guidelines from the USA, so we should get the same protection?
Nothing could be further from the truth, with profit greed by the big drug companies overtaking the truth.
For decades, studies have shown that there is a correlation between Autism and vaccinations, but the big drug companies and Governments have always denied any relationship. Advice from Governments has always been that vaccinations do not cause autism.
However, in May 2016, after over a hundred FOIA (Freedom of Information Act) requests, the CDC was forced to release the proof they have known for years: That a vaccine preservative CAUSES AUTISM!
The preservative is Thimerosal, which was banned for use in children in 1999, but still used in more than 60 vaccines, and proven to cause autism.
Scientists have been attempting to alert the public, but their statements have been dismissed, or even made appear foolish by the corrupt pharmaceutical industry.
Every vaccination has an adjuvant, which has dual properties: Fist as a preservative, second to cause inflammation.
Inflammation is deemed necessary, because the fever forces the body to view this injected foreign material as an invader, and build immune system antibodies to the invaders.
While this can work in the majority of cases, it often fails in cases where:

  • The patient has a compromised immune system
  • The patient has an abnormal allergy response
  • The patient has been taking panadol (paracetamol, or in the USA, acetaminophen)

Vaccine Adjuvants

why are aluminium salts effective as adjuvants and why do we use them? The latter is easily answered. They are extremely cheap, essentially they cost nothing relative to other vaccine constituents, and there are absolutely no regulations as to the use of aluminium salts, either as adjuvants or otherwise. Adjuvants, including aluminium-based, are effective because of their toxicity at the vaccine injection site. One of the most effective adjuvants is Freund’s Complete Adjuvant (a preparation of dried and inactivated mycobacteria) but this adjuvant is too toxic to be used in human vaccinations. Aluminium salts are the most widely used adjuvants because their toxicity at the injection site is deemed acceptable in the light of the advantage gained from vaccination against the particular antigen. The toxicity induced by aluminium adjuvants at injection sites is almost certainly due to the free aluminium cation, Al3+, which is released from the injected aluminium salt. The cell death which is a consequence of the toxicity results in an inflammatory response and this is the origin of the swollen red tissue at the injection site almost immediately following vaccination. The toxicity of an aluminium adjuvant depends upon the aluminium salt with aluminium hydroxyphosphate (known commercially as AdjuPhos™) being more toxic at the injection site than aluminium oxyhydroxide (known commercially as AlHydrogel™). The aluminium adjuvant used in the Gardasil HPV vaccine is a sulphated version of aluminium hydroxyphosphate and is likely, based upon what we know about aluminium chemistry, to be even more toxic. Unfortunately, Merck, the manufacturers of this adjuvant have not made it available for any independent analyses, never mind safety testing. The visual evidence of the toxicity of aluminium adjuvants at the injection site is limited by their intramuscular administration (the adjuvant is hidden away in the muscle tissue) while their actual injection site toxicity is experienced by many as significant muscular pain, and associated events, in the receiving limb which can last for hours and even days. However, the role of the injection site toxicity is to attract a variety of immune-responsive cells and these cells proceed to load up their cell cytoplasm with particles of aluminium adjuvant as well as antigen, the latter may or may not be associated with the adjuvant material. Thereafter, dogma dictates that the delivery of antigen to lymph nodes initiates antigen-specific adaptive immunity. We have recently learned that the migratory cells which populate the injection site following vaccination are capable of loading up their cell cytoplasm with particles of aluminium adjuvant without these particles having any immediate effect upon cell viability . These immune-responsive cells are subsequently found in lymph nodes but they are also capable of transporting their cargo of aluminium throughout the body including gaining access to the brain. These aluminium-loaded migratory cells remain viable in the shorter term because the particulate aluminium salt in their cytoplasm is enclosed in membrane-bound vesicles. However, these vesicles undergo a progressive acidification which in turn dissolves the enclosed aluminium salt to release biologically reactive Al3+ which will eventually cause the membrane-bound vesicle to rupture and consequently release large amounts of biologically available aluminium into the cell cytoplasm. The inevitable consequence of this is cell death and where this cell death occurs will simply depend upon the trajectory of the cells upon leaving the vaccine injection site. Theoretically at least this is a mechanism whereby a significant, indeed acute, amount of aluminium could be released into areas distant from the injection site such as brain tissue. It is undeniable that a small proportion of individuals receiving vaccines which include aluminium adjuvants experience what have been called severe adverse events and such ‘events’ include brain encephalopathies. These severe adverse events are almost certainly caused by aluminium adjuvants and recent research showing how immune-responsive cells load up their cytoplasm with particulates of aluminium now offers mechanistic insight into how aluminium adjuvants are not only always toxic at the vaccine injection site but how they can occasionally be toxic at distant sites in the body too. Why some individuals are more susceptible to toxicity due to aluminium adjuvants is the subject of ongoing research.

Dangers of Paracetamol

Doctors still mistakenly advise parents to give their child paracetamol (Paracetamol, Panadol) before any vaccination, which is a BIG MISTAKE.
Paracetamol reduces the fever, in turn reducing the body’s natural immune response to the vaccination, reducing the effectiveness of the production of antibodies.
Even worse, a natural enzyme in the body in combination with Paracetamol, destroys Glutathione, the body’s MASTER ANTIOXIDANT.
Destruction of Glutathione compromises our immune system makes us much more susceptible to almost any disease.
When Glutathione levels drop to around 30% of normal, liver cell death starts, and other conditions start also because of low Glutathione.
Poisoning can occur with an accidental or deliberate overdose, or even continued use at the recommended dose.
Paracetamol poisoning requires urgent hospital treatment. Symptoms often do not appear before 24 hours after ingestion, and NAC (N-Acetyl-Cysteine) is administered. NAC is available as a supplement, but do not try to treat any poisoning at home!

Cuba

In Cuba, where there is over 99% vaccination rate for children, more than most of the USA, there is an Autism rate of around 1 in 12,000 to 1 in 60,000. The data reporting in Cuba may influence the numbers, but when we compare the USA rate of 1 in 45, then clearly there is a problem in the USA. A few decades ago, Autism was almost unknown in the USA and Australia.
What is the difference? Why are USA children over a thousand times more likely to get Autism than Cuban children? Part of the answer is:
In Cuba, Paracetamol (acetaminophen) is prescription-only, where in Australia and the USA anyone can buy it almost anywhere with no prescription.
Apart from apparently causing Autism, Paracetamol also causes liver damage. Because this dangerous drug is marketed as “Safe and Effective” there is a public perception that a small overdose would not be harmful, but in fact a single pill causes harm by depleting Glutathione, and it is true to say that most of the people on the liver transplant waiting list are there because of a paracetamol overdose!
The second part of the answer:
In Cuba, there is a high vaccination rate, but the difference is that Cuba makes it’s own vaccines, there are no large drug companies seeking dollar profit only, so the quality of vaccines is higher, and the vaccine schedule is much less aggressive, with Cuban children under 5 receiving some 11 vaccinations, compared with 40 in the USA.
So with so many vaccinations in the USA, the children must be healthier, we would think?
Not so. In fact, the USA has the highest death rate of children under five, than all other developed countries in the world!

Dangers of Adjuvants

Adjuvants are added to vaccines to supposedly make them more effective.
Adjuvants are mixed with an antigen from a virus or bacteria to deliberately create a greater inflammatory immune response, theoretically providing a higher response of protective antibodies.

Thimerosal Adjuvant

Thimerosal is a vaccine adjuvant that contains mercury, which is a human carcinogen and:

  • Causes Autism and many other conditions affecting the brain
  • Causes Cancer
  • Is a mutagen (interferes with DNA)
  • Is a teratogen (causes birth defects)
  • Reduces immunity
  • Causes Alzheimer’s Disease and other brain issues

Thimerosal metabolises into toxic, dangerous methylmercury, then converted to inorganic mercury which is even more harmful and very hard for the body to excrete.
For those with a compromised immune system already, this destroys much of an already weakened immune system, leading to many diseases.

Aluminium Adjuvant

Most, if not all inactivated vaccines use aluminium (aluminum in the USA) as an adjuvant.
The problem with aluminium is that it is toxic to the human body, believed to cause Alzheimer’s and many other brain diseases. When aluminium is swallowed, less than 1.5% is absorbed by the body. But if injected into muscle tissue, as happens in a normal vaccination, then 100% is absorbed into the body. Add to this the very high number of vaccinations we are told our children need, plus extra aluminium from food and drink containers, cooking utensils, foil food wraps, etc, this becomes way too much.

How are vaccines made?

Depends on the type of vaccine.

The Standard Flu Shot

The standard process uses 500,000 fertilized chicken eggs every day for about eight months, so hundreds of millions of fertilised eggs are used every year, “mini incubators” for cultured viruses. When the chick embryos are eleven days old, the egg white (the amniotic fluid) is injected with a drop of solution containing the virus. After a few days, the viral suspension is then centrifuged, which removes much, but not all, chicken tissue and blood. Whatever remaining egg protein and blood is included in the final vaccine. This is why those with an allergy to eggs are advised not to receive a flu shot.
Given the very large numbers of eggs required, do you think they would select only the most expensive pasture-raised free range eggs? I think not. They would buy the cheapest eggs possible – factory farmed cage eggs, where the chickens are invariably sick, never see the light of day, are loaded up with cheap antibiotics to keep them alive long enough for them to produce the eggs, and would undoubtedly be full of unknown viruses. Salmonella is rampant among factory-farmed eggs, and the different strains of Salmonella cause illnesses such as typhoid fever, paratyphoid fever, and food poisoning.
The antibiotics destroy some bacteria, but this tends to help proliferate the antibiotic-resistant bacteria, and the chickens are then even more susceptible to viruses, because antibiotics destroy beneficial gut bacteria which provide immunity in chickens as well as humans.

Cell Line Technologies

This is another vaccine manufacturing method, using cells and tissues for growing vaccine viruses, used since the 1950’s.
In June 2014, the all-clear was given to use cells from the kidney of a Cocker Spaniel dog which died in 1958 to make the Flu and other vaccines.
Cells from animals used in vaccines includes:

  • Calf lymph for Smallpox vaccines
  • Mouse brain cells for Japanese Encephalitis vaccines
  • MRC-5 and WI-38 cells from aborted human fetal tissue were developed in the 1960’s and still used for Rubella, Chickenpox, Hepatitis A and Shingles vaccines
  • African green monkey cells (AGMK cells) for polio vaccines – see below

Still want to get a flu shot?

African green monkey cells (AGMK cells) for polio vaccines caused the HIV/AIDS virus

More Lies from the CDC (Centers for Disease Control)

New science which almost certainly proves that the HIV/AIDS virus was NOT caused by Africans eating infected monkeys, but from a Polio vaccine made from African green monkey cells injected into more than one million Africans, giving them HIV/AIDS directly, which has then spread to the rest of the world via blood transfusions, anal sex, dirty needles and other methods similar to vaccinations.
These monkeys were already infected with the SIR virus which transmuted into the HIV/AIDS virus in humans.
Of course, the medical profession denied this, and published many documents claiming why this was impossible, but modern science has blown major holes in this “evidence” as an obvious cover-up.
As the drug industry changes from egg-incubation methods to animal cell incubation, how do we know the effects on humans and how the virus will transmutate and spread?
Obviously, no one knows. No one cares. All the drug companies are concerned about is making money, not healing people. If people get sick from their vaccines, the drug companies get paid to make yet more vaccines. Even in cases where they can protect people from a certain disease, who knows what other diseases they are infecting people with?

Truth about Polio

India introduced an Injectable Polio Vaccine (IPV) in the routine immunisation programme for all children under 5 years old, claiming it “will be an important step in the Polio Endgame Strategy”, This appeared to work: India has not reported a single case of polio caused by the wild polio virus (WPV) since January 2012.
FAKE NEWS – There has been around 50,000 cases of flaccid paralysis, which is exactly like polio!
It is now called “Vaccine Derived Polio Virus (VDPV)” in medical literature.
Yes, the polio vaccine causes polio, but to protect the drug manufacturers and the politicians, they call this condition “Acute Flaccid Paralysis” or AFP.
Symptoms of AFP include fever, sudden muscle weakness in one or more limbs, just like polio. Many things cause AFP, but one cause is the polio vaccine!
AFP is less common in Western countries, because of two things; better sanitation and cleaner drinking water.
According to the American journal Pediatrics, there is an undeniable link between the increase in incidence of NPAFP (non-polio AFP) and the number of Oral Polio Vaccine (OPV) doses delivered in any region. OPV contains an attenuated (weakened) vaccine-virus. The weak form of the polio virus is used to activate an immune response in the body, which then protects the child when challenged by WPV. But when a child is immunised with OPV, the weakened vaccine-virus replicates in the intestine. During this time, the vaccine-virus is also excreted. In areas of inadequate sanitation, this excreted vaccine-virus can quickly spread in the community and infect children with low immunity. This excreted vaccine undergoes genetic changes as it circulates in the community and causes VDPV.
The government states that VDPV is still comparatively rare, as it has to circulate for a long time in the community of under-immunised or poor-immune children before it can infect and cause paralysis in someone.
The government’s only strategy is the addition of Inactivated polio vaccine (IPV)
A 2005 study in the Indian Journal of Medical Research on NPAFP found that a fifth of cases of NPAFP were reported from Uttar Pradesh. Researchers found that 35.2% of children with AFP had paralysis and 8.5 per cent died, about double the rate of paralysis and death if the child had the original Polio!
The government is still basking in the glory of one of its rare public health achievements for eradicating polio, while cases of flaccid paralysis have seen a huge resurgence.
Nearly 50,000 children fall prey to polio-like flaccid paralysis every year, with over 15,000 paralysed and over 4,000 die!

Reported side effects from vaccinations

Most side effects go unreported.
If a patient sees a doctor for an illness after a vaccination, the patient usually does not make the connection, and if they do, the doctor often refuses to admit there may be a connection. Even though laws in the USA prevent doctors from being sued because of injury or death from a vaccination, they are naturally always reluctant to admit that their action caused the injury or death.
If we view studies on reported side effects, then it is likely that unreported side effects may range from double to hundreds of times the reported side effects, especially mild side-effects like a fever, rash, feeling unwell, etc which the doctor will say is “probably just a virus” or “a coincidence”.
Guillian-Barre Syndrome is a devastating condition, shown to be caused by 5 in every million vaccinations. Perhaps only a small number, but devastating if we are one of those 5.
Article here: www.greenmedinfo.com/article/risk-guillain-barr-syndrome-after-2010-2011-influenza-vaccination

The Flu vaccine causes six times more respiratory infections

We are told by Government health “experts” that: “The flu vaccine protects the very young and the very old, the groups most likely to suffer serious respiratory complications from the flu.”
And they say: “It is important everyone else get the flu vaccine to further protect these vulnerable segments of the population.”
But these statements are FALSE.
If the flu vaccine really works, then a non-vaccinated person should not be able to infect any vaccinated person, young or old.
Of course, the vaccine does NOT work.
Governments force everyone working in haspitals, schools, child care, prisons, welfare, etc to have the flu shot, but the results speak for themselves. They still get the flu just like the rest of the population, but they get it WORSE than the unvaccinated group, who get the flu, recover, and have then a natural immunity to help prevent future attacks when the flu virus develops into a different strain, and reduce severity of future attacks.
Evidence proves the flu vaccine is a failure, ESPECIALLY in the very old, and the 2014-2015 annual flu vaccine in the USA does not cover half of the flu viruses in circulation. Even in years when the CDC (Centers for Disease Control and Prevention) does get it better, vaccination does not protect the elderly against serious flu complications. The typical success rate for seniors is claimed to be 30% (which I call a 70% failure rate), even if we can believe them. Children now do not get the flu shot because of an alarming number of cases of severe health issues after the shot.
Governments also claim that if anyone still gets the flu after being vaccinated, then their symptoms will be milder, and they will recover around one day earlier. Of course, they omit to tell us that if we have a glass of lemon juice and water every day and forget the flu shot, we are less likely to get the flu at all, and if we do, the symptoms will be milder, and we will recover at least a day earlier, and our risk of cancer and Alzheimer’s disease will be substantially reduced! And if we add vitamin C, vitamin D3, vitamin A, probiotics, and stick to a healthy diet and avoid antibiotics, we will probably NOT get the flu at all!
LeanMachine changed his lifestyle completely at age 63, and 8 years later at age 71, has not had a cold, flu, any other illness, not even a headache!
There are very few studies on preventing disease without vaccinations, as there is no money in it for the big drug companies, but LeanMachine has embodied all he has learned in 8 years of research in a one-person study, proving to himself, if no one else, that vaccinations are not necessary.

The Flu vaccine causes miscarriages

Recent studies have shown that women who have the flu shot in at least two consecutive years, have increased risk of spontaneious abortions (Miscarriages) compare to women who do not get the shot.
This means that thousands of would-be babies have never been born alive and well, a disaster for the parents involved.
The drug companies put their spin on this situation, but no matter how they manipulate the data, the results come out the same.
This study was carried out by the CDC, who are pawns to the drug industry, so an independent study would have come out even worse.

Are non-vaccinated Children Healthier?

The flu shot effect on children:

The U.S. government still refuses to carry out a single study comparing vaccinated to non-vaccinated children, because “it would be unethical to deprive any child of the vaccine.”
However, nothing can be ethical without scientific validation. It’s a good thing we have all those full-time, non-physician bioethicists guiding the government and the academic medical research complex. Maybe they should all go back to Bioethics 101.
Fortunately, in 2012, scientists in Hong Kong did conduct a scientific test of vaccination on children.
It’s probably one of the few, if not the only, true scientific study on the effectiveness of flu vaccines in children conducted in recent years, and it revealed the absurdity of vaccination “science.”
The study was a double-blind, placebo-controlled trial, the same kind designed to study drugs before they are approved.
Of course, mainstream medical researchers insist upon using this methodology to assess natural therapies too, even when it is completely inadequate and inappropriate. But in this case, the design is perfect for demonstrating the effectiveness of a vaccine, or lack thereof, as it turned out.
Researchers divided the children into two groups.
The first group received the trivalent flu vaccine (meaning the vaccine contained three strains of influenza circulating that season).
The second group received a salt solution, a genuinely inactive treatment, as the placebo.
(Curiously, most vaccine trials use active placebos, or substances already found in the vaccines, which makes the results meaningless, but this fact is almost never revealed.)
Then, they followed the children for about nine months.
At the end of the trial period, the researchers said they found no “statistically significant” difference in the risk of influenza infection between the two groups. In other words, they found NO BENEFIT from the vaccine.
But when you look at the actual numbers, it is a different story.
In fact, 116 children in the vaccinated group caught the flu. But only 88 children in the placebo group got it. In other words, nearly 25 percent more children who received the flu vaccine got the flu compared to children who didn’t get the vaccine. I would hardly call that difference “statistically insignificant.”
And another interesting point…
The vaccinated children had evidence in their blood of antibodies against the flu, as you would expect when you inject a vaccine. The study authors suggested that the presence of these antibodies provided benefits to the children. But if the children still had the same or greater risk of actually getting the flu, then what difference did it make?
Clearly, the vaccine did NOT protect the children from getting sick in other ways either. In fact, the vaccinated group ended up getting almost six times more respiratory infections. To be more specific, the vaccinated group experienced 230 cases of rhinovirus (common cold) and the non-vaccinated placebo group experienced only 59 cases. That’s 75 percent fewer cases!
Furthermore, there were 160 cases of Coxsackie/Echovirus (Enterovirus, causing bronchiolitis, bronchitis and exacerbations of asthma) in the vaccinated group, but ZERO cases in the non-vaccinated placebo group.
Among other respiratory viruses, there were 97 in the vaccinated and only 88 in the placebo.
Of course, the common cold is not a life-threatening illness. Coxsackie and Echovirus usually just cause minor respiratory symptoms, although they both can also cause hepatitis, heart disorders, meningitis, and paralysis.
But these infections certainly aren’t enjoyable for children or their parents, amd often lead to parents administering dangerous medications, like acetaminophen (also called Panadol, Paracetamol, Tylenol, etc), to alleviate their child’s symptoms. So why increase a child’s chances of coming down with one of these “harmless” viruses? And if viruses are harmless, then why vaccinate in the first place?
The study authors concluded in their report that the trivalent influenza vaccine “could increase influenza immunity” even though their results showed it INCREASED actual flu cases, and clearly reduced the children’s immunity against non-influenza respiratory viruses. They blamed this “unusual” finding of increased risk on some “unknown” biological mechanism.
“Unknown”? It is NOT unknown. In fact, vaccines interfere with normal immune system responses, so interfere with the ability to fight other infections. We have known about this phenomenon in virology for more than half a century.
On the contrary, this study gives us many “known” conclusions!
First, influenza vaccines provide NO BENEFIT.
Second, they carry a huge risk of other respiratory illnesses.
Third, they likely harm the normal immune response.
But the facts are up against the alphabet soup of CDC, FDA and NIH, as well as WHO, all heavily influenced by the big drug companies.
Henri Pasteur, a true pioneer of effective vaccination, would be rolling over in his grave at the current state of affairs. Or, perhaps shouting, “Sacre bleu.”

Too many vaccinations?

Children in the USA are expected to get 48 doses of 14 vaccines by the time they’re just 6 years old. By age 18, federal public health officials say they should have gotten a total of 69 doses of 16 vaccines from day of birth to age 18. This “prescription” is supposed to keep children healthy and free of disease, but, incredible as it may sound, no scientific study has ever proven this to be the case.
The cost to immunize a child in 1985 when Dr Mercola started practice was about US$80. In 2016, largely because in the increase in the number of vaccines, plus general cost increases, that cost has risen to US$2,200. This is an ENORMOUS increase, and you can begin to imagine the amount of revenue that is being generated from forcing mandatory vaccinations on the entire population.
It seems painfully obvious that in order to justify the expense and the risk of side effects inherent in the U.S. vaccination schedule, it would have to be proven that this series of shots is actually effective, safe and better than receiving no shots at all. The only way to do this would be to compare the health of vaccinated children with that of non-vaccinated children, and see which group fares better.
But such a common-sense study comparing the health of vaccinated vs. non-vaccinated children has never been done in the United States for any vaccination!
That is, until now…

Vaccinated vs. non-vaccinated: Survey Reveals Who’s Healthier

In December 2010, a survey was initiated by www.vaccineinjury.info to compare the health of vaccinated children with non-vaccinated children. To date over 7,850 surveys have been submitted, and the study is ongoing, so if you have a non-vaccinated child (or are non-vaccinated yourself) and would like to submit his or her health data, you can do so here.
Though this is obviously not a double-blind controlled study, and depends on the individuals submitting the data to give accurate information, it is still incredibly revealing.
So far, the results show:

Health Condition Prevalence in Vaccinated Children Prevalence in non-vaccinated Children
Allergies 40% report at least one allergy Less than 10%
Asthma 6% 2.5%
Hayfever 10.7% of German children 2.5%
Neurodermatitis (an autoimmune disorder) 13% of German children 7%
ADHD 8% of German children, and another nearly 6% with borderline cases 1-2%
Middle ear infections 11% of German children Less than 0.5%
Sinusitis Over 32% of German children Less than 1%
Autism Approximately 1 in 100 Only 4 cases out of 7,800+ surveys (one child tested very high for metals, and another’s mother tested very high for mercury)

In the chart below, from www.vaccineinjury.info, we can see a direct comparison of health data from the KiGGs study (The German Health Interview and Examination Survey for Children and Adolescents) versus the data from non-vaccinated children taking part in VaccineInjury.info’s survey:
Vaccine Injury Survey

Vaccine Autism Connection

Although nearly every major vaccine “expert” will vehemently deny the connection between autism and vaccines, there is no question in my mind at all that it exists. They quote seriously flawed and biased research to support their position, and because it is published in scientific journals (which are in large part funded by the drug companies), most health care professionals and the public believe it.
However, objective analysis, like the one featured here, show what nearly every other study shows:
That the incidence of autism has increased to 1 in 100 in those that were vaccinated.
No one disagrees with this. What is fascinating is that the incidence in the non-vaccinated group was about one in 2,000 which is still more than in the past, but TWENTY times lower risk than in the vaccinated group.
Fortunately it appears that we do have a risk factor and a test that you can use that will help you understand if your child is at risk for autism.
After all, 99 kids in 100 did NOT get autism. So wouldn’t it be great to identify the risk factor BEFORE you vaccinate your child and correct it? Remember, we are all about SAFE vaccine policies and radically lowering their risk. It is up to parents to review the evidence and make the choice, but if you decide to vaccinate I could not more strongly recommend listening to the interview Dr Mercola did with Dr. McBride, and follow her screening and treatment recommendations.

Make Sure You Believe in Artificial Immunity Before You Vaccinate

It is quite clear from the data above that vaccinated children are not healthier than their non-vaccinated peers, despite what the public health agencies would like you to believe. What is not clear is why vaccinated children appear to be sicker, and although this survey does not establish cause and effect, it does suggest that the vaccinations themselves are involved.
There are numerous mechanisms by which a vaccine could potentially damage your health:
Contaminationadjuvants, and preservatives like mercury, to name just a few. But an often-overlooked component is the very way in which they are intended to build your immunity, which is artificially. The presumed intent of a vaccination is to help you build immunity to potentially harmful organisms that cause illness and disease. However, your body’s immune system is already designed to do this in response to organisms that invade your body naturally.
Most disease-causing organisms enter your body through the mucous membranes of your nose, mouth, pulmonary system or your digestive tract, NOT through an injection.
These mucous membranes have their own immune system, called the IgA immune system. It is a different system from the one activated when a vaccine is injected into the body. Our IgA immune system is our first line of defence, by fighting off invading organisms at the entry points, reducing or even eliminating the need for activation of the body’s immune system.
However, when a virus is injected into your body in a vaccine, and especially when combined with an immune adjuvant, our IgA immune system is bypassed and our body’s immune system kicks into high gear in response to the vaccination. Adjuvants can trigger unwanted immune responses, as they can cause your immune system to over-react to the introduction of the organism you’re being vaccinated against.
According to Barbara Loe Fisher, president and co-founder of the National Vaccine Information Center:
“Vaccines are supposed to fool your body’s immune system into producing antibodies to resist viral and bacterial infection in the same way that actually having the disease usually produces immunity to future infection.
But vaccines atypically introduce into the human body lab-altered live viruses and killed bacteria along with chemicals, metals, drugs and other additives such as formaldehyde, aluminum, mercury, monosodium glutamate, sodium phosphate, phenoxyethanol, gelatin, sulfites, yeast protein, antibiotics as well as unknown amounts of RNA and DNA from animal and human cell tissue cultures.
Whereas natural recovery from many infectious diseases usually stimulates lifetime immunity, vaccines only provide temporary protection and most vaccines require “booster” doses to extend vaccine-induced artificial immunity.
The fact that man-made vaccines cannot replicate the body’s natural experience with the disease is one of the key points of contention between those who insist that mankind cannot live without mass use of multiple vaccines and those who believe that mankind’s biological integrity will be severely compromised by their continued use.”

Why did Australia, Europe, and the U.S. Ban the Flu Vaccine for Children Under 5?

In 2010, Australia temporarily suspended its seasonal flu program for children under the age of five after detecting an abnormal number of side effects within 12 hours of vaccination, compared to previous years.
The vaccine in question was Fluvax, manufactured by CSL Limited. Side effects included high fevers and seizures.
One infant also lapsed into a coma.
After a three-month investigation, the Australian Department of Health resumed seasonal flu vaccinations for young children, stating that “the higher than usual occurrence of fever and febrile convulsions appears to be confined to the vaccine Fluvax” and advised parents to continue vaccinating their children with another brand. The link to this study has now disappeared…
Now, however, it’s being reported that an 18-month investigation by CSL found the reactions appear to have occurred due to the combination of swine flu and seasonal flu strains in the vaccine, a mix that had never before been concocted.
CSL reported:
“Our scientific studies indicate that the interaction between the particular virus strains used in the 2010 … vaccine contributed to the reactions, but we are still working to understand the how and why.”
The Fluvax vaccine has now been banned for children under 5 in Australia, Europe and the United States due to the increased rate of convulsions in children who received the vaccine. Meanwhile, the swine flu vaccine even on its own has been linked to unusual side effects as well. In fact, new data from Sweden, released at the end of June, show the vaccine raises the risk of narcolepsy by nearly 660 percent!
It is very clear that vaccines do not cause problems for everyone who receives them, but when they do, it can be an unmitigated disaster. The reaction may be acute, such as fever or swelling, or it may be chronic and show up much later, such as narcolepsy or an increased propensity for allergies and autoimmune diseases. Long-term health outcomes post-vaccination are typically not studied, so surveys like the one noted above are now offering the first real look at the potential long-term health risks of vaccination.
Remember that when you or your child is injured by a vaccine, the risks are 100 percent, and you will be left to deal with the consequences.

FluMist Worthless Against Influenza

The Washington Post wrote about why the FluMist vaccine suddenly stopped working.
This spray form of the flu vaccine was preferred over the injected form for children between 2 and 8 years old. FluMIst is a “live attenuated vaccine”, meaning it contains a live but weakened version of the flu virus.
However, a CDC advisory panel found that the nasal spray “was so ineffective that it should not be used by anyone during the 2016 to 2017 season.”
Data from the 2015 Winter showed FluMist to be only 3% effective in 2 to 17 year old children. Nearly all who received FluMist risked their health for nearly zero benefit!
MedImmune are the makers of FluMist, and have not determined why their product fails.
The Washington Post reported:
“In any given flu season, vaccine effectiveness varies. One factor is how well the vaccines match the virus that is actually prevalent. Other factors include the age and general health of the recipient. In the overall population, the CDC says studies show vaccines can reduce the risk of flu by about 50 to 60 percent when the vaccines are well matched. Now, researchers are trying to find a common factor behind FluMist’s recent incidents of poor performance.”
Researchers will attempt discover if the flu vaccine loses effectiveness when given to a child who has been previously vaccinated against influenza several times.

I consider that the vaccine makers do not know as much about their products as they say, but despite this, they insist that vaccines are beneficial and worth almost any risk to the population to protect society at large.

So – before you decide to get a flu shot, or any vaccination, for yourself or your child, remember that some vaccines can cause serious health problems, and when it comes to pandemic vaccines like the H1N1 swine flu vaccine, these risks may be magnified due to them being fast-tracked.
Further, in many cases there are far safer ways to protect your children and yourself against disease, and you just might wind up being inherently healthier for it in the future.

HPV – Gardasil – The Killer Vaccine

In Waukesha, Wisconsin, a 12 year old girl (Meredith Prohaska) suddenly died, only hours after receiving the HPV Gardasil vaccine.
This was an enormous shock to the girl’s family, and local media was asking the questions: How could this happen?
Dr. Geoffrey Swain of the local health department was interviewed to give the standard CDC reply, which is similar to almost every other vaccine, stating that severe reactions like this resulting in death are “very rare,” and about “1 out of a million”.
Assuming that there is some data to back up the claim of only “1 out of a million,” how many doses of the HPV vaccine are administered every year? According to statistics (July 2014) published by the U.S. Department of Health and Human Services, over 9 million per year. So the government admits that at least 9 girls per year are killed by the HPV vaccine. How many parents know this prior to taking a doctor’s advice to administer this vaccine that is supposedly a protection against cervical cancer caused by the HPV (human papillomavirus), a sexually transmitted disease?
Since the HPV vaccinations began, LeanMachine believes that almost 200 girls have died (up to around 2017), and thousands more physically maimed for life, with many of those perhaps wishing that they were the ones who have died, their injuries so severe they can never have a normal life, never bear children, never get out of a wheel chair.
After the news announcement that Meredith Prohaska had died from receiving the HPV vaccine, at least one other parent contacted a local news station to report that her 17-year-old daughter also had a serious adverse reaction to the HPV vaccine, requiring urgent care at a local hospital. The local news affiliate asked the question: “So what are the odds another local girl had a similar reaction after getting the shot?”
Here is the report:
The local news media, possibly covering the HPV vaccine for the first time, were all quick to interview and provide links to the official CDC view of the vaccine.
But here are some other facts regarding the vaccine that they failed to disclose, probably because they did not take the time to look outside of the standard government response to events like this, or their station managers did not allow them to give any other news outside of what the CDC claims.

1. There are many more reported side effects than just death from the HPV vaccine. Human papilloma virus vaccine has caused primary ovarian failure. Another problem of the autoimmune/inflammatory syndrome induced by adjuvants.
Australian pediatrician, Dr. Deirdre Little, was the first to sound the alarm over the HPV vaccine causing premature menopause when she observed it in one of her 16 year old patients in 2012. Two sisters from Wisconsin say a cervical cancer vaccine shut down their ovaries and almost certainly left them never able to get pregnant.

The Cochrane Nordic Center reported that the EMA (European Medicines Agency) ignored data showing the severe adverse events associated with the HPV vaccine. Functional disorders were shown to be caused by the vaccine or the adjuvants used in the vaccine.
The EMA’s internal 256-page report contradicts the final 40-page official report. Chochrane said “We find that the EMA’s comments are unprofessional, misleading, inappropriate and pejorative, and that the EMA’s approach involves cherry-picking, which is unscientific.”
The Uppsala centre compared reported adverse events following HPV vaccination with all other vaccines given to women, and found that the HPV vaccine has a FAR greater risk of severe side effects than ANY other vaccine!
And the EMA still claims no conclusions could be drawn from the following official data:

  • POTS reported 82 times for HPV vaccines vs only 1 time for other vaccines
  • CRPS reported 69 times for HPV vaccines vs only 16 times for other vaccines
  • Autonomic nervous system imbalance reported 77 times for HPV vaccines vs 16 times for other vaccines
  • Fibromyalgia reported 62 times for HPV vaccines versus 39 times for other vaccines

Disorders Linked to HPV Vaccine:

  • CFS (Chronic fatigue syndrome)
  • POTS (Postural orthostatic tachycardia syndrome)
  • CRPS (Chronic regional pain syndrome)
  • Premature menopause
  • Infertility
  • Narcolepsy and/or Cataplexy
  • Autoimmune Disorders
  • Guillain–Barré syndrome (GBS)
  • Fibromyalgia
  • Autonomic nervous system issues
  • Stroke
  • Venous thromboembolism (VTE)
  • Appendicitis
  • Seizures
  • Syncope (fainting)
  • Allergic reactions

2. Countries Outside the U.S. Are Halting HPV Vaccines: Lawsuits due to Damages are Mounting.

  • Gardasil Vaccine: Spain Joins Growing List of Countries to File Criminal Complaints
  • Supreme Court in India to Rule on Merck Fraud Regarding HPV Vaccine Deaths
  • Merck’s Former Doctor Predicts that Gardasil will Become the Greatest Medical Scandal of All Time.
  • Japan Halts HPV Vaccine and Begins Full-Scale Probe over Safety Issues.
  • Ten more young women file criminal complaints due to injuries from Gardasil Vaccine in France.
  • Israel Health Ministry considers canceling HPV vaccination due to side effects.

3. We Cannot Sue the Manufacturer of Vaccines in the U.S. because they have total legal immunity!

Most of the U.S. public is unaware that a U.S. citizen, by law, cannot sue a pharmaceutical company for damages resulting from vaccines. Congress gave them total legal immunity in 1986, and that law was upheld by the U.S. Supreme Court in 2011. There is a special “vaccine court” called the National Vaccine Injury Compensation Program that is funded through a tax on vaccines. If you are injured or killed by a vaccine, you must hire an attorney and fight tax-funded government attorneys to seek damages, as you cannot sue the drug manufacturers. It can take 10 years or longer to win your case and be compensated. The U.S. Department of Health and Human Services usually publishes a report every couple of months on settlements on their website.
So from 1986, the vaccine manufacturers saw an enormous money-pit, where they started inventing new vaccines for every disease imaginable, and why not? They did not have to advertise to get sales, they just had their puppets and shareholders at the CDC and Government mandate the vaccinations as compulsory.
They could not get sued, so it did not matter if the vaccine did not work, or if it killed or maimed people. They got away scot-free to continue doing it to this day.

4. The U.S. Government Earns Royalties from the sale of the Gardasil HPV Vaccine.
Dr. Eric Suba tried to use the Freedom of Information Act to find out how much money the National Institute of Health (NIH) earned from the sale of Gardasil, but they refused to report the amount of revenue the government earns from this vaccine (although not denying they do earn royalties).

5. Conflict of Interest.
Julie Gerberding was in charge of the CDC (Center for Disease Control) from 2002 to 2009, which includes the years the FDA approved Gardasil as a vaccine. Soon after she took over the CDC, she reportedly completely overhauled the agency’s organizational structure. Many of the CDC’s senior scientists and leaders either left or announced plans to leave. Some have claimed that almost all of the replacements Julie Gerberding appointed had ties to the vaccine industry. Gerberding resigned from the CDC on January 20, 2009, and is now the president of Merck’s Vaccine division, a 5 billion dollar a year operation, and the supplier of the largest number of vaccines the CDC recommends.

6. Black women who are vaccinated with Gardasil are vaccinated against the wrong strains.
Scientists at the Duke University School of Medicine discovered that African American women carry HPV strains not found in the Gardasil vaccine. Moshella Roberts, a 20-year-old African American woman died needlessly from the HPV vaccine.

Although some local news affiliates report deaths and injuries from the Gardasil vaccine, they do not research or present all of the facts, they simply copy what the CDC says. Many fear to raise the issue of the “Gardasil controversy” because it may jeopardize their journalistic careers, and can be forced to apologise for even suggesting the HPV vaccine is not totally safe.

So – conduct your own research before making any decisions on any vaccine, especially the HPV (Gardasil) vaccine!

Vaccine Reaction Symptoms

Symptoms may include any or many of the following, but often viewed by doctors as unrelated to the vaccine:

  • Pronounced swelling, redness, heat or hardness at the injection site
  • Body rash or hives
  • Shock
  • Collapse
  • High pitched screaming or persistent crying for hours
  • Extreme sleepiness or long periods of unresponsiveness
  • Twitching or jerking of the body, arm, leg or head
  • Crossing of eyes
  • Weakness or paralysis of any part of the body
  • Loss of ability to roll over, sit up or stand up
  • Loss of eye contact or awareness, or social withdrawal
  • Head banging or onset of repetitive movements (flapping, rubbing, rocking, spinning)
  • High fever (over 39.5 degrees C or 103 degrees F)
  • Vision or hearing loss
  • Restlessness, hyperactivity or inability to concentrate
  • Sleep disturbances that change wake/sleep pattern
  • Joint pain or muscle weakness
  • Disabling fatigue
  • Loss of memory
  • Chronic ear infections
  • Respiratory infections
  • Violent or persistent diarrhea or chronic constipation
  • Breathing problems (asthma)
  • Excessive bleeding (thrombocytopenia) or anemia

There can be many other symptoms that may indicate that you or your child has suffered a vaccine reaction.
Not all symptoms following vaccination are caused by the vaccine received, but it cannot be automatically concluded that symptoms are NOT related to the vaccine. Unfortunately, adverse reactions to vaccines are under-reported, often because mild symptoms can be vague, and many doctors would rather blame a virus rather than admit their action caused the problem. Some say only 10% are reported, while others say less than 1% are reported. It is very important that the doctor records all health problems occuring after vaccination in the patient’s permanent medical record, also to report any symptoms to the TGA in Australia, or VAERS in the USA. Any re-vaccination MUST be postponed until the issue developed after vaccination has been investigated and found absolutely unrelated to the vaccination.
Continued vaccination after serious health problems may lead to injury or death.

How to Reduce Risk of Disease Without a Vaccine

The best defense against any disease is a strong immune system, but vaccines can compromise immunity rather than build immunity.
Building the immune system naturally is essential for resistance to disease.
Research proves that vitamin D is essential for optimal health, but Australia’s 30-year “Slip, Slop, Slap” campaign to keep everyone out of the sun has been the biggest disaster of all time, causing countless deaths from cancer and other diseases, all because of sub-optimal Vitamin D.
For more info, read my article vitamin D
Our immune system determines whether we get sick or not when we are exposed to any infectious disease. The main keys to immunity are:

  • Healthy food
  • Stress free living
  • Good sleep
  • Regular exercise
  • Sunlight and Vitamin D

For more information, the National Vaccine Information Center (NVIC) is a great resource, with objective and unbiased information.
Everyone has the right to the ability to make intelligent, informed decisions about which vaccines you may want for ourselves and our families.

The LeanMachine Experience

LeanMachine always had several bouts of cold and flu every year until the age of 63. Then came a complete change of lifestyle: Sugar, processed foods, dairy, fluoride and other toxins were removed from the diet. Supplements of minerals and vitamins (especially Vitamin D3) were added to the diet. Since then, 8 years down the track at age 71: Zero colds, flu, not even a headache, allergies disappeared, more energy, obese build now lean.
No vaccinations of any kind. Same goes for Mrs LeanMachine, no colds or flu and no vaccinations, yet we have both been heavily exposed to all diseases at shopping centres, meetings, etc where everyone around us is coughing, spluttering, sneezing.

LeanMachine online shop

Disclaimer

LeanMachine is not a doctor, and everyone should consult with their own health professional before taking any product to ensure there is no conflict with existing prescription medication.
LeanMachine has been studying nutrition and health since 2011 and has completed many relevant studies including:
Open2Study, Australia – Food, Nutrition and Your Health
RMIT University, Australia – Foundations of Psychology
Swinburne University of Technology, Australia – Chemistry – Building Blocks of the World
University of Washington, USA – Energy, Diet and Weight
Johns Hopkins Bloomberg School of Public Health, USA – Health Issues for Aging Populations
Johns Hopkins Bloomberg School of Public Health, USA – International Nutrition
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics I
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics II
Johns Hopkins Bloomberg School of Public Health, USA – Principles of Human Nutrition
TUFTS University, USA – Nutrition and Medicine
TUFTS University, USA – Lipids/Cardiovascular Disease I and Lipids/Cardiovascular Disease II
Technical Learning College, USA – Western Herbology, Identification, Formulas
Bath University, England – Inside Cancer
WebMD Education – The Link Between Stroke and Atrial Fibrillation
WebMD Education – High Potassium: Causes and Reasons to Treat
Leiden University Medical Center, Netherlands – Anatomy of the Abdomen and Pelvis
MIT (Massachusetts Institute of Technology) – A Clinical Approach to the Human Brain
LeanMachine has now examined thousands of studies, journals and reports related to health and nutrition and this research is ongoing.

Posted 13th August 2018, updated 3rd November 2019, Copyright © 1999-2019 Brenton Wight and BJ & HJ Wight trading as Lean Machine abn 55293601285