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Auti-Immune conditions are becoming more common, when they were almost unheard of just decades ago. Poor Vitamin D3 and poor nutrition are the two main causes.

 

The Overlooked Vitamin That Improves Autoimmune Disease and Autonomic Dysfunction

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Posted on: Monday, February 1st 2021 at 4:45 am
Written By: Ali Le Vere, B.S., B.S. – Senior Researcher-Greenmedinfo
This article is copyrighted by GreenMedInfo LLC, 2021

Thiamin may be the missing link to treating autoimmune disease and autonomic dysfunction. Although deficiencies in this vitamin have long been considered eradicated, case studies show supplementation with this nutrient improves fatigue in autoimmune patients in a matter of hours to days

One of the common threads uniting disparate autoimmune disease labels, irrespective of diagnosis, is the debilitating fatigue that plagues patients. Although methylated B vitamins have been given ample fanfare, vitamin B1, or thiamin, has garnered far less attention in communities that emphasize the holistic management of autoimmune disease.

Functions of Thiamin

One of eight essential B vitamins, thiamin is a water-soluble vitamin that functions in the conversion of food into energy (1). The active form of thiamin, known as thiamin pyrophosphate or thiamin diphosphate, is an essential cofactor in both the citric acid cycle and pentose phosphate pathway, two enzyme-mediated pathways of carbohydrate metabolism (1). The citric acid cycle, for example, also known as the Kreb’s cycle, is a central metabolic pathway in the mitochondria that participates in the oxidative degradation of monosaccharides and other nutrients, which generates cellular energy currency in the form of adenosine triphosphate (ATP) to be used in a myriad of energy-demanding cellular reactions (1).

Inhibition of the two main enzymes of the Kreb’s cycle for which thiamin is a cofactor, pyruvate dehydrogenase complex (PDH) and alpha-ketoglutarate dehydrogenase (alpha-KGDH), leads to decreased brain levels of ATP (1). Suppression of brain ATP levels impairs degradation of dopamine in the prefrontal cortex, disrupts synthesis of the nerve-insulating myelin sheath, prevents production of the neurotransmitter acetylcholine, and reduces levels of the major inhibitory neurotransmitter gamma aminobutyric acid (GABA), which collectively leads to delirium, delusions, hallucinations, and cognitive impairment (1).

The transketolase enzyme of the cytosol-based pentose phosphate pathway (PPP), on the other hand, also requires thiamin as a cofactor (1). Transketolase converts glucose-6-phosphate into both ribose-5-phosphate and reduced nicotinamide adenine dinucleotide phosphate (NADPH), the latter of which is required to donate hydrogen atoms in chemical reactions that produce particular neurotransmitters, steroids, amino acids, fatty acids, and the master antioxidant of the body, glutathione (1). Given its centrality to these biochemical pathways which generate energy for the entire organism, the effects of thiamin deficiency are all-encompassing.

The Re-Emergence of Thiamin Deficiency Disorders

The relationship between food and berberi, the classical syndrome of thiamin deficiency, was first discovered by Japanese naval surgeon Takaki in the late nineteenth century, who found that nearly two-thirds of his crew were stricken with berberi after a long voyage. Two years later, when he loaded another warship with dry milk and meat, he noticed that a much smaller percentage of the crew succumbed to berberi, such that “Takaki concluded that the disease was caused by a lack of nitrogenous food in association with excessive intake of non-nitrogenous food” (2).

In addition to impaired reflexes, peripheral neuropathy, edema, cardiovascular abnormalities and hypesthesia, or a diminished capacity for physical sensation, signs of autonomic dysfunction such as sinus tachycardia, vasovagal syncope, mitral valve prolapse, hypotension, sweating, dermographia, and attention deficit are a prominent part of the clinical expression of berberi (2, 3). Other extreme manifestations of thiamin deficiency include Wernicke’s encephalopathy, which includes signs such as ataxia, weakness, paralysis, cognitive impairment, apathy, significant spatial and temporal disorientation, and problems with movement in the muscles around the eyes such as ocular palsies, nystagmus, and opthalmoplegia (1). These symptoms are caused by lesions in brain areas including the hypothalamic nuclei, tectal plate, periventricular nuclei, thalamus, pontine tegmentum, and abducens and oculomotor nuclei, and untreated, lead to coma and death (1).

Korsakoff’s psychosis is often a progression of Wernicke’s encephalopathy (4), and includes symptoms such as amnesia, decreased initiative, and confabulation, which means distorted, fabricated, or misinterpreted memories. Although thiamin deficiency, and its extreme incarnations in particular such as Wernicke’s encephalopathy and Korsakoff’s psychosis, is considered a medical emergency, 80% of the time these diagnoses are made during autopsy (5), mainly due to low index of suspicion, and the nonspecific clinical signs of these syndromes (1).

Although the benefit of thiamin in these classical syndromes of thiamin deficiency, which were recorded as far back as the ninth century, is uncontested, milder forms of thiamin deficiency often elude diagnosis. Marginal thiamin deficiency presents with vague symptomatology, including fatigue, irritability, abdominal pain, frequent headaches, and a decline in growth rate in children (6). The World Health Organization states, in fact, that, thiamin deficiency is a clinical diagnosis confirmed upon improvement with thiamin administration:

The symptoms of mild thiamin deficiency are vague and can be attributed to other problems, so that diagnosis is often difficult…The symptoms of mild thiamin deficiency clinically improve by the administration of thiamin.(7)

In the minds of conventional providers, deficiency diseases have been eradicated in the industrialized world; however, unbeknownst to the medical establishment, it is our Western diets that are facilitating the re-emergence of these diseases considered long-abolished:

Perhaps, in the light of more modern knowledge, it is possible to state that high simple carbohydrate malnutrition can cause symptoms of early beriberi. Since beriberi conjures up an unacceptable concept in the mind of many modern physicians it is probable that it would not be considered in differential diagnosis. It is very likely that many of the poorly understood symptomatology seen today that responds to nutrient therapy is caused by a mixture of marginal classic nutritional diseases, including beriberi, pellagra and scurvy.(2)

Efficacy of Thiamin in Inflammatory Bowel Disease

Especially encouraging are the results of a small open-label pilot study of thiamin use in patients with inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, who presented with fatigue and lingering extra-intestinal symptoms despite their diseases being characterized as quiescent or in remission (8). Patients, all of whom had normal thiamin levels at the commencement of the study, were treated orally with 600 milligrams per day of thiamin, with additional doses in increments of 300 mg per day for those cases in which regression of fatigue was not considered satisfactory, up to a total of 1,500 mg per day (8). In other words, the dose was defined empirically, with calibration based upon subject weight and according to symptomatic remission.

All but two of the twelve patients exhibited a complete regression of fatigue, and in the remaining two, near complete regression was observed (8). Moreover, one hundred percent of patients reported complete regression of symptoms associated with fatigue (8). Impressively, the majority of patients also displayed improvements in intestinal function, with marked reductions in the number of diarrhetic episodes (8).

Notably, in one of the series of case studies presented, fatigue disappeared completely after intramural thiamin injection, and authors mention that “within 20 days, the patient regained complete wellness” (8). This study confirmed findings by Magee and colleagues, who found that consumption of thiamin-rich foods decreases disease activity in patients with ulcerative colitis (9).

Effect of Thiamin in Hashimoto’s Thyroiditis

Another series of case reports published in The Journal of Alternative and Complementary Medicine chronicles the use of thiamin in patients with Hashimoto’s thyroiditis who had persistent symptoms such as fatigue, depression, anxiety, sleep disruption, impaired memory and concentration, dry skin, and cold intolerance despite normal thyroid parameters (10). Patients, all of whom exhibited normal blood levels of thiamin and TPP prior to treatment, were administered either 600 mg per day of oral thiamin or 100 mg per mL of thiamin administered parenterally every four days, depending on weight (10).

In the two patients given oral thiamin, complete regression of fatigue occurred within 3 to 5 days, whereas fatigue regressed within 6 hours in the patient given intramuscular thiamin therapy (10). Although case studies rank low on the hierarchy of evidence-based data, and underscore the need for higher quality research, the mechanism linking functional thiamin deficiency to autoimmune-based fatigue is so plausible that the study authors assert:

While further studies are necessary to confirm our findings, we strongly believe that our observations represent an important contribution to the relief of many patients.(10)

Reasons Underlying Thiamin Deficiency in Autoimmunity

As indicated by the IBD pilot study in which all patients exhibited normal levels prior to treatment, yet still responded favorably to thiamin supplementation, tests of thiamin and thiamin pyrophosphate (TPP), the active form of thiamin, may be of no value in identifying functional thiamin deficiency (8).

Normal serum levels of thiamin and TPP, in fact, indicate normal thiamin absorption by the small intestine (8). Researchers instead attribute the symptoms of thiamin deficiency that appeared in these autoimmune patients in both studies to either structural enzymatic defects or to dysfunction of the vitamin B1 active intracellular transport mechanism from the blood to the mitochondria (8). Administration of large quantities of vitamin B1, on the other hand, is able to circumvent this abnormality:

The administration of large quantities of vitamin B1 orally increases the concentration in the blood to levels in which the passive transport restores the normal glucose metabolism. The glucose metabolism of all organs goes back to normal values and fatigue disappears.(8)

As an alternative explanation, one author in the New England Journal of Medicine proposes that a deficiency in activity of one thiamin transporter can cause another to pick up the slack when high doses of thiamin are administered. This occurs because one member of the solute carrier (SLC) gene family of transporter proteins, which possess structural similarity, can substitute for the function of another.

In other words, at large doses, thiamin can induce expression of the solute carrier gene family member SLC19A2, which encodes the human thiamin-only transporter 1 (hTHTR1), in order to compensate for defects in SLC19A3, which encodes the human thiamin and biotin transporter 2 (hTHTR2) (11). Increasing the concentration of blood thiamin also augments the chances that it crosses the blood brain barrier (BBB) to correct neurological deficits, since thiamin penetration of the BBB occurs via passive diffusion, an energy-independent process, when there is a surplus of thiamin available (12).

Food-Based Sources of Thiamin

Only plants, bacteria, and fungi can synthesize thiamin, so humans must acquire thiamin from external food sources. Because they are nutrient-poor, breads and cereals are oftentimes fortified with thiamin, but ingestion of these foodstuffs for thiamin sufficiency is counter-intuitive, since simple carbohydrates increase the need for thiamin. Although data on thiamin content of foods is limited (13), whole-food sources of thiamin include liver and other sources of offal, meat, pork, poultry, fish, eggs, dried legumes, nuts, and whole grains such as brown rice and bran (2).

Additionally, other plants which have relatively high thiamin content include Nicaraguan cacao, black cohosh, spirulina, string beans, kidney beans, black beans, navy beans, green beans, peas, black-eyed peas, bael fruit, asparagus, macambo, sunflower seed, shepherd’s purse, okra, high mallow, sow thistle, mountain buchu, watercress, and garlic (14). However, cooking and heat-processing of food results in considerable thiamin losses, so preparation methods matter from a thiamin sufficiency perspective (2).

Thiamin Repletion: Correcting the Deficiency

Of note, is that the dose administered in the IBD study is much higher than that which can be obtained from food, and approximately 600-fold higher than the daily recommended intake for men and women older than ten years of age (1). Due to the supra-physiological nature of the dosing regimen, patients should consult with a naturopathic or integrative doctor prior to consuming a dose of this magnitude.

However, the safety profile of thiamin, as observed in the literature, demonstrates that this intervention is benign. Unlike other immunosuppressant drugs often administered for autoimmune diseases, which can be accompanied by catastrophic side effects such as infection and cancer, there are no collateral effects of thiamin administration, even when used at high doses long-term (10).

In fact, thiamin is nontoxic to the body even at excess amounts (15), and doses as high as 3 to 8 grams per day have been used to treat Alzheimer’s disease without adverse effects (8). Only mild tachycardia appeared in one patient in the IBD study, which abated upon reduction of the dose (8).

This safety profile stands in stark contrast to a drug like hydroxychloroquine (Plaquenil), which is often prescribed to improve fatigue in autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, sarcoidosis, rheumatoid arthritis, and Sjögren’s syndrome, which poses the risk of potentially irreversible retinopathy (16) that may progress to blindness even 7 years after the drug has been discontinued (17). Similarly, newer generation biologic drugs such as antitumor necrosis factor (anti-TNF) therapy and anti-T cell strategies carry risk of autoimmune disease itself, causing the very diseases they are designed to treat in a cruel poetic irony (18).

 

Other considerations for using thiamin include integrating supplementation with a broad-spectrum low-dose B vitamin formulation to prevent any imbalances in B vitamins. Likewise, another factor often at play is magnesium deficiency, since the conversion process of thiamin to its metabolically active form requires magnesium as a cofactor (19). Therefore, magnesium deficiency should be corrected, since hypomagnesaemia can mimic thiamin deficiency (1).

Although scientists state, “We deem necessary a lifelong use of high doses of thiamin in affected subjects,” researchers are unable to clarify whether the aberration in thiamin transport is secondary to genetic mutations or to an autoimmune-inflammatory process (8), which raises the possibility that resolution of the underlying immune dysregulation, namely, through approaches that restore an evolutionarily appropriate diet and lifestyle template, may negate the need for high-dose thiamin long-term.

Forms of Thiamin

One potential limiting factor of thiamin use is its poor bioavailability and slower absorption as a supplement, which is why high doses of thiamin are prescribed for certain medical conditions (3). To circumvent this issue, researchers have developed fat-soluble derivatives of thiamin called allithiamines. Benfotiamine, one lipophilic derivative of thiamin which readily diffuses through biological membranes, has been shown to have clinical benefit in diabetic vascular complications (3).

Its mechanisms of action includes reduction of advanced-glycation end products (AGEs), highly oxidant compounds with pathogenic significance in aging and chronic disease states (20), and modulation of pathways that play roles in cell survival, death, and repair (3). Impressively, benfotiamine also reduces activation of the nuclear factor kappa beta (NFkB) signaling pathway, the gateway to inflammatory eicosanoid mediators, and mitigates signaling down the arachidonic acid pathway, inhibiting the same cyclooxygenase (COX) enzymes (3) exploited by non-steroidal anti-inflammatory drugs (NSAIDs) without the deleterious side effects.

In addition, benfotiamine has been found to have free radical-scavenging properties via its ability to modulate levels of enzymes involved in endogenous antioxidant defense, such as catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) (3). Not only that, but benfotiamine reduces activity of glycogen synthase kinase 3 (GSK-3), which is involved in deposition of β-amyloid plaques in the brain in Alzheimer’s disease (3). Proof-of-concept of its neuroprotective abilities have been demonstrated in recent studies showing that benfotiamine reduces plaque accumulation, improves symptomatology (3), and inhibits progression of cognitive impairment in Alzheimer’s disease (21). Therefore, due to its pleiotropic effects, thiamin in this form has the potential to improve a host of chronic, inflammatory, and neurodegenerative conditions.

Removing Anti-Thiamin Agents

Predisposing factors for thiamin deficiency include malnutrition, acquired immunodeficiency syndrome (AIDS), gastrointestinal surgical procedures such as vertical banded gastroplasty, gastric bypass surgery, colectomy, and intragastric balloon, and psychiatric disorders including anorexia nervosa, bulimia, and binge-eating disorders (1). Certain medical conditions, such as pancreatitis, renal disease, thyrotoxicosis, celiac disease, cancer, peptic ulcers, and other gastrointestinal disorders are likewise associated with increased risk of thiamin deficiency (1).

However, chronic alcoholism poses special risk, since it interferes with the rate-limiting step of carrier-mediated thiamin absorption in the duodenum (22), alongside impairing the storage and phosphorylation of thiamin that is essential to its function (1). In addition, thiamin deficiency is under-recognized in obesity and is implicated in the progression of obesity-related chronic disease states (Maguire et al., 2018). Furthermore, people with type 1 and type 2 diabetes have plasma thiamin levels that are 76% and 50% to 75% lower, respectively, than healthy volunteers (24, 25).

Certain dietary factors, such as simple carbohydrates, also have anti-thiaminergic properties (9), which is referred to as high-calorie malnutrition when excessive intake produces thiamin deficiency. Carbohydrates increase the need for the vitamin since thiamin is a major factor in the metabolism of glucose (2). What’s more, polyphenolic compounds present in tea and coffee can inactivate thiamin (2).

Also problematic are sulfiting agents, including sulfites, sulfur dioxide, hydrogen sulfites, and metabisulfites, which are used as food preservatives to prevent microbial growth, food spoilage, and discoloration, and to extend the shelf life of the product (9). Sulfites, which are contained in foods such as wines, lager, non-organic processed meats such as sausage and burgers, sulfited seafoods, and soft drinks from concentrate, are problematic because of their anti-thiamin effects, since thiamin is readily cleaved by the sulfite ion, particularly at a colonic pH (9). The role of sulfites reinforces the thiamin-autoimmune connection, as studies of ulcerative colitis have elucidated a role of sulfited foods in the pathogenesis of the disease, with high sulfite foods producing worse sigmoidoscopy scores (9)—presumably due in part to thiamin depletion.

Therapeutic Potential for Thiamin in Autoimmune Disease

Researchers state that the role of thiamin as a medicinal agent is under-appreciated in Western civilization (26). Although deficiency disorders are considered afflictions of developing societies, the prevalence of subclinical thiamin deficiency has been demonstrated to be on the rise (3). In addition, because a response to thiamin therapy is considered diagnostic of thiamin deficiency, in concert with its excellent safety profile, a trial of thiamin poses little risk. As asserted by researchers in The Journal of Alternative and Complementary Medicine,

Our team is convinced that the fatigue correlated with all autoimmune inflammatory diseases is a manifestation of an intracellular mild thiamin deficiency likely due to thiamin transporter deficiency or to enzymatic dysfunctions.(8)

Not only does thiamin deficiency cause mitochondrial dysfunction, but it also results in oxidative stress, which is central to the pathophysiology and perpetuation of autoimmune disorders. Not only that, but some of the cardinal symptoms of thiamin deficiency are features of autonomic dysfunction, or dysautonomia, which 24% to 100% of autoimmune patients have been shown to experience (27). Therefore, restoration of thiamin status in autoimmune patients has the potential to ameliorate a vast array of symptoms, since the autonomic nervous system is responsible for a diversity of largely unconscious physiological activities including digestion, urination, defecation, heart rate, blood pressure, pupillary response, and sexual arousal.

Lastly, another line of reasoning connecting autoimmunity to thiamin deficiency is postural orthostatic tachycardia syndrome (POTS), a form of dysautonomia with suspected autoimmune etiology that is often comorbid with other autoimmune diseases (28). The symptoms of POTS, which has been shown to respond to thiamin supplementation in some cases (29), resemble berberi.

Given the ubiquity of anti-thiamin agents in the Western diet alongside problems with thiamin transport in autoimmune patients, these preliminary studies raise the possibility of thiamin as a potent therapeutic option for autoimmune disorders alongside a holistic regimen that addresses mindfulness, toxicity, diet, and lifestyle.


References

  1. Osiezagha, K. et al. (2013). Thiamin deficiency and delirium. Innovations in Clinical Neuroscience, 10(4), 26-32.
  2. Lonsdale, D. (2006). A Review of the Biochemistry, Metabolism and Clinical Benefits of Thiamin(e) and Its Derivatives. Evidence Based Complementary and Alternative Medicine, 3(1), 49-59.
  3. Raj, V. et al. (2018). Therapeutic potential of benfotiamine and its molecular targets. European Review for Medical and Pharmacological Sciences, 22, 3261-3273.
  4. Zubaran, C., Fernandes, J.G., & Rodnight, R. (1997). Wernicke-Korsakoff syndrome. Postgraduate Medical Journal, 73(85%), 27-31.
  5. Thomson, A.D., Guerrini, I., & Marshall, E.J. (2009). Wernicke’s encephalopathy: role of thiamine. Practices in Gastroenterology, 33(6), 21-30.
  6. Shikata, E. et al. (2000). “Iatrogenic” Wernicke’s encephalopathy in Japan. European Neurology, 44(3), 156–161.
  7. World Health Organization, United Nations High Commissioner for Refugees. (1999). Thiamin Deficiency and Its Prevention and Control in Major Emergencies. Retrieved from https://www.who.int/nutrition/publications/emergencies/WHO_NHD_99.13/en/
  8. Costantini, A., & Pala, M.I. (2013). Thiamin and Fatigue in Inflammatory Bowel Diseases: An Open-label Pilot Study. The Journal of Alternative and Complementary Medicine, 19(8), 704-708.
  9. Magee, E. et al. (2005). Association between diet and disease activity in ulcerative colitis patients using a novel method of data analysis. Nutrition Journal, 4(7).
  10. Costantini, A., & Pala, M.I. (2014). Thiamin and Hashimoto’s Thyroiditis: A Report of Three Cases. The Journal of Alternative and Complementary Medicine, 20(3), 208-2011.
  11. Kono, S. et al. (2009). Mutation in a thiamin-transporter gene and Wernicke’s like encephalopathy. New England Journal of Medicine, 360, 17921.
  12. Thomson, A.D. (2000). Mechanisms of vitamin deficiency in chronic alcohol misusers and the development of the Wernicke-Korsakoff syndrome. Alcohol & Alcoholism, 35(Suppl 1), 2–7.
  13. National Institutes of Health: Office of Dietary Supplements. (2018). Thiamin: Fact Sheet for Professionals. Retrieved from https://ods.od.nih.gov/factsheets/Thiamin-HealthProfessional/#en7
  14. United States Department of Agriculture, Agricultural Research Service. (1992-2016). Dr. Duke’s Phytochemical and Ethnobotanical Databases. Home Page, https://phytochem.nal.usda.gov/ https://dx.doi.org/10.15482/USDA.ADC/1239279
  15. Hope, L.C., Cook, C.C., & Thomson, A.D. (1999). A survey of the current clinical practice of psychiatrists and accident and emergency specialists in the United Kingdom concerning vitamin supplementation for chronic alcohol misusers. Alcohol and Alcoholism, 4(6), 862–867.
  16. Lehne, R.A. (2007). Pharmacology for Nursing Care. St. Louis, Missouri: Saunders-Elsevier Inc.
  17. Abdulaziz, N. et al. (2018). Hydroxychloroquine: balancing the need to maintain therapeutic levels with ocular safety: an update. Current Opinion in Rheumatology, 20(3), 249-255. doi: 10.1097/BOR.0000000000000500.
  18. Chandrashekara, S. (2012). The treatment strategies of autoimmune disease may need a different approach from conventional protocol: A review. Indian Journal of Pharmacology, 44(6), 665-671.
  19. Zieve, L. (1969). Influence of magnesium deficiency on the utilization of thiamin. Annals of the New York Academy of Science, 162(2), 732–743.
  20. Uribarri, J. (2010). Advanced Glycation End Products in Foods and a Practical Guide to Their Reduction in the Diet. Journal of the American Dietetic Association, 110(6), 911-916.e12.
  21. Pan, X. et al. (2016). Long-term cognitive improvement after benfotiamine administration in patients with Alzheimer’s disease. Neuroscience Bulletin, 32, 591-596.
  22. Todd, K.G., Hazell, A.S., & Butterworth, R.F. (1999). Alcohol-thiamin interactions: an update on the pathogenesis of Wernicke encephalopathy. Addiction Biology, 4(3), 261–272.
  23. Maguire, D. et al. (2018). The role of thiamine dependent enzymes in obesity and obesity related chronic disease states: A systematic review. Clinical Nutrition ESPEN, 25, 8-17.
  24. Thornalley, P.J. et al. (2007). High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease. Diabetologia, 50, 2164-2170.
  25. Al-Attas, O.S. et al. (2012). Blood thiamine and its phosphate esters as measured by high-performance liquid chromatography: levels and associations in diabetes mellitus patients with varying degrees of microalbuminuria. Journal of Endocrinology Investigations, 35, 951-956.
  26. Lonsdale, D. (2011). Thiamin(e): The Spark of Life. Water Soluble Vitamins, 199-227.
  27. Stojanovich, L. (2009). Autonomic dysfunction in autoimmune rheumatic disease. Autoimmune Reviews, 8(7), 569-572.
  28. Blitshteyn, S. (2015). Autoimmune markers and autoimmune disorders in patients with postural tachycardia syndrome (POTS). Lupus, 24(13), 1364-1369.
  29. Blishteyn, S. (2017). Vitamin B1 deficiency in patients with postural tachycardia syndrome (POTS). Neurology Research, 39(8), 685-688.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

 

Attacking Ourselves: Top Doctors Reveal Vaccines Turn Our Immune System Against Us

© 28th December 2020 GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC.
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Posted on: Monday, December 28th 2020 at 1:00 pm
Written By: Celeste McGovern
This article is copyrighted by GreenMedInfo LLC, 2020

Attacking Ourselves: Top Doctors Identify 4 Groups Most Likely to Suffer Vaccine Injury

The research is hard to ignore, vaccines can trigger autoimmunity with a laundry list of diseases to follow. With harmful and toxic metals as some vaccine ingredients, who is susceptible and which individuals are more at risk?

No one would accuse Yehuda Shoenfeld of being a quack. The Israeli clinician has spent more than three decades studying the human immune system and is at the pinnacle of his profession. You might say he is more foundation than fringe in his specialty; he wrote the textbooks. The Mosaic of AutoimmunityAutoantibodiesDiagnostic Criteria in Autoimmune Diseases, Infection and Autoimmunity, Cancer and Autoimmunity – the list is 25 titles long and some of them are cornerstones of clinical practice. Hardly surprising that Shoenfeld has been called the “Godfather of Autoimmunology” – the study of the immune system turned on itself in a wide array of diseases from type 1 diabetes to ulcerative colitis and multiple sclerosis.

But something strange is happening in the world of immunology lately and a small evidence of it is that the Godfather of Autoimmunology is pointing to vaccines – specifically, some of their ingredients including the toxic metal aluminum – as a significant contributor to the growing global epidemic of autoimmune diseases. The bigger evidence is a huge body of research that’s poured in in the past 15 years, and particularly in the past five years. Take for example, a recent article published in the journal Pharmacological Research in which Shoenfeld and colleagues issue unprecedented guidelines naming four categories of people who are most at risk for vaccine-induced autoimmunity.

“On one hand,” vaccines prevent infections which can trigger autoimmunity, say the paper’s authors, Alessandra Soriano, of the Department of Clinical Medicine and Rheumatology at the Campus Bio-Medico University in Rome, Gideon Nesher, of the Hebrew University Medical School in Jerusalem and Shoenfeld, founder and head of the Zabludowicz Center of Autoimmune Diseases in the Sheba Medical Center at Tel Hashomer. He is also editor of three medical journals and author of more than 1,500 research papers across the spectrum of medical journalism and founder of the International Congress on Autoimmunology. “On the other hand, many reports that describe post-vaccination autoimmunity strongly suggest that vaccines can indeed trigger autoimmunity. Defined autoimmune diseases that may occur following vaccinations include arthritis, lupus (systemic lupus erythematosus, SLE) diabetes mellitus, thrombocytopenia, vasculitis, dermatomyosiositis, Guillain-Barre syndrome and demyelinating disorders. Almost all types of vaccines have been reported to be associated with the onset of ASIA.”

ASIA – or Autoimmune/inflammatory Syndrome Induced by Adjuvants (also known as Shoenfeld’s syndrome) — first appeared in the Journal of Autoimmunology four years ago. It is an umbrella term for a collection of similar symptoms, including Chronic Fatigue Syndrome, that result after exposure to an adjuvant – an environmental agent including common vaccine ingredients that stimulate the immune system. Since then an enormous body of research, using ASIA as a paradigm, has begun to unravel the mystery of how environmental toxins, particularly the metal aluminum used in vaccines, can trigger an immune system chain reaction in susceptible individuals and may lead to overt autoimmune disease.

Autoimmune disease results when the body’s system meant to attack foreign invaders turns instead to attack part of the body it belongs to (auto is Greek for self). If the immune system is like a national defence system, antibodies are like drones programmed to recognize a certain type of invader (a bacteria say) and to destroy them or mark them for destruction by other special forces. Autoantibodies are like drones that are misidentifying a component of the human body and have launched a sustained attack on it. If they mistakenly target a component of the conductive sheath around neurons, for example, nerve impulses stop conducting properly, muscles go into spasm and coordination fails; multiple sclerosis results. If autoantibodies erroneously focus on joint tissue; rheumatoid arthritis results. If they target the islets of Langerhans in the pancreas, Type 1 diabetes, and so on

“Throughout our lifetime the normal immune system walks a fine line between preserving normal immune reactions and developing autoimmune diseases,” says the paper. “The healthy immune system is tolerant to self-antigens. When self-tolerance is disturbed, dysregulation of the immune system follows, resulting in emergence of an autoimmune disease. Vaccination is one of the conditions that may disturb this homeostasis in susceptible individuals, resulting in autoimmune phenomena and ASIA.”

Who is “susceptible” is the subject of the paper entitled, “Predicting post-vaccination autoimmunity: Who might be at risk?” It lists four categories of people: 1) those who have had a previous autoimmune reaction to a vaccine, 2) anyone with a medical history of autoimmunity, 3) patients with a history of allergic reactions, 4) anyone at high risk of developing autoimmune disease including anyone with a family history of autoimmunity, presence of autoantibodies which are detectable by blood tests and other factors including low vitamin D and smoking.

PREVIOUS REACTION

Regarding those who have had a previous adverse reaction to vaccines, the paper cites five relevant studies including the case of a death of a teenage girl six months following her third Gardasil injection against HPV virus.  She had experienced a range of symptoms shortly after her first dose, including dizziness, numbness and tingling in her hands, and memory lapses. After her second injection, she developed “intermittent arm weakness, frequent tiredness requiring daytime naps,” worse tingling, night sweats, chest pain and palpitations. A full autopsy was unrevealing but blood and spleen tissue analysis revealed HPV-16 L1 gene DNA fragments – matching the DNA found in vials of the Gardasil vaccine against cervical cancer – “thus implicating the vaccine as a causal factor.” The DNA fragments had also been found to be “complexed with the aluminum adjuvant” which, according to the report, have been shown to persist for up to 8 to 10 years causing chronic immune system stimulation.

“Although data is limited,” Shoenfeld and his colleagues concluded, “it seems preferable that individuals with prior autoimmune or autoimmune-like reactions to vaccinations, should not be immunized, at least not with the same type of vaccine.”

ESTABLISHED AUTOIMMUNE CONDITION

The second group which the paper cites for vaccine exemption is patients with “established autoimmune conditions.” Vaccines don’t work so well in them, say Shoenfeld and his colleagues, and they are at “risk for flares following vaccination.” Inoculations that contain live viruses including chickenpox, yellow fever and the measles, mumps and rubella triple vaccine (MMR) are “generally contraindicated” for people with autoimmune conditions because of  the risk of “uncontrolled viral replication.” But inactivated vaccines are not such a good idea either because they usually contain the added ingredient aluminum, linked to autoimmunity.

The immunologists describe recent studies in which patients with autoimmune rheumatic disease given the influenza vaccine (without aluminum) suffered more joint pain and fever than controls and whose levels of autoantibodies (the drones that attack self)  increased after receiving the flu vaccine. What’s more, they developed new types of autoantibodies that weren’t present before the vaccines, and those persisted. As the presence of autoantibodies can be predictive of developing autoimmune disease in patients without symptoms, even years ahead of disease onset, this is troubling to those who understand immunology.

A number of studies claim vaccines are safe for the “overwhelming majority of patients with established autoimmune diseases,” the study allows, but they only looked at rheumatoid arthritis and lupus and not at severe and active cases so “the potential benefit of vaccination should be weighed against its potential risk,” they cautioned.

PATIENTS WITH A HISTORY OF ALLERGY

Vaccine trials have usually excluded “vulnerable” individuals — only extremely healthy individuals with no allergies are recruited. It’s a “selection bias,” say Soriano and Shoenfeld, and has likely resulted in serious adverse events being “considerably underestimated” in “real life where vaccines are mandated to all individuals regardless of their susceptibility.” The true incidence of allergic reactions to vaccines, normally estimated at between one in 50,000 to one in a million doses, is probably much higher and particularly where gelatin or egg proteins are on the ingredients list, they say.

There’s a long list of vaccine ingredients that are potential allergens: besides the infectious agents themselves, there are those from hen’s egg, horse serum, baker’s yeast, numerous antibiotics, formaldehyde and lactose, as well “inadvertent” ingredients such as latex. People’s allergic histories have to be taken before vaccination say the researchers. But some signs of reaction don’t show up until after the shot.

The public health nurse or GP might tell patients that a long-lasting swelling around the injection site after a vaccine is a normal reaction, for example. But that is not what the immunologists say. “[A]luminum sensitization manifests as nodules [hard lumps] at the injection site that often regress after weeks or months, but may persist for years.” In such cases, they say, a patch test can be done to confirm sensitivity and to avoid vaccination.

According to a growing body of research, though, allergy may be only the beginning of many dangerous aluminum-induced phenomena.

THE TROUBLE WITH ALUMINUM

Aluminum has been added to vaccines since about 1926 when Alexander Glenny and colleagues noticed it would produce better antibody responses in vaccines than the antigen alone. Glenny figured the alum was inducing what he called a “depot effect” – slowing the release of the antigen and heightening the immune response. For 60 years his theory was accepted dogma. And over the same time, the vaccine schedule grew decade on decade, but few ever questioned the effects of injecting aluminum into the body, which is strange considering its known toxicity.

A PubMed search on aluminum and “toxicity” turns up 4,258 entries. Its neurotoxicity is well documented. It affects memory, cognition, psychomotor control; it damages the blood brain barrier, activates brain inflammation, depresses mitochondrial function and plenty of research suggests it is a key player in the formation of the amyloid “plaques” and tangles in the brains of Alzheimer’s patients. It’s been implicated in Amyotrophic Lateral Sclerosis and autism and demonstrated to induce allergy.

When kidney dialysis patients were accidentally infused with aluminum, the “dialysis-induced encephalopathy” (DAE) they developed neurological symptoms: speech abnormalities, tremors, memory loss, impaired concentration and behavioural changes. Many of the patients eventually went into comas and died. The lucky ones survived: when the source of toxicity, aluminum, was removed from their dialysis they recovered rapidly.

With these new observations, researchers began investigating the adjuvant effects of aluminum and in the past decade there has been a flurry of research. Far from being a sandbag that holds the antigen for a while and then gets excreted, it turns out that aluminum salts trigger a storm of defence action. Within hours of injection of the same aluminum oxyhydroxide in vaccines into mice, for example, armies of specialized immune cells are on the move, calling in grid coordinates for more specialist assault forces. Within a day, a whole host of immune system commandos are in play — neutrophils, eosinophils, inflammatory monocytes, myeloid and dendritic cells, activating lymphocytes and secreting proteins called cytokines. The cytokines themselves cause collateral damage but they send out signals, directing cell-to-cell communication and recruiting other cells into action. If the next phase of the attack is launched: fibroblast growth factor, interferons, interleukins, platelet derived growth factor, transforming growth factor and tumour necrosis factor might all be engaged. There’s evidence that poorly understood and pesky inflammasomes, (currently a topic of cutting- edge cancer causation research) such as the Nod-like receptor 3( NLRP) are activated too, but it’s all still too early to say exactly what they’re doing.

New research emerging from University of British Columbia has found that aluminum adjuvant injected into mice can alter the expression of genes associated with autoimmunity. And in their recent study published in the Proceedings of the National Academy of Sciences, immunologists at the University of Colorado found that even host DNA is recruited into the aluminum assault, that it rapidly coats injected alum, triggering effects that scientists have barely scratched the surface of understanding.

THE SIGNIFICANCE OF MACROPHAGIC MYOFASCIITIS

This mobility or “translocation” of aluminum in the body is perhaps the most disturbing of the mounting evidence in current aluminum research. In 1998, French researcher Romain Gherardi and his colleagues observed an emerging condition of unknown origin which presented in patients post-vaccination with Chronic Fatigue like symptoms including swollen lymph nodes, joint and muscle pain and exhaustion. Tissue biopsies of the patients’ deltoid revealed lesions up to 1 cm in diameter and unique from similar lesions of other diseases. They went to the lab for analysis and to Gherardi’s astonishment, they mainly consisted of macrophages – large white blood cells in the immune system whose job is to swallow up foreign invaders in the body. Enclosed in the cellular fluid of these phagocytes were agglomerates of nanocrystals of aluminum.

Gherardi and his colleagues began injecting mice with aluminum to see what happened. Their research published in 2013 revealed that the metal particles were engulfed by macrophages and formed MMF-like granulomas that dispersed — to distant lymph nodes, spleen, liver and eventually brain.

“This strongly suggests that long-term adjuvant biopersistence within phagocytic cells is a prerequisite of slow brain translocation and delayed neurotoxicity,” writes Gherardi in his February 2015 review of the relevant research in Frontiers in Neurology.

A more frightening animal study of aluminum is that of Spanish veterinary researcher Lluis Lujan’s study of ovine ASIA. After huge numbers of sheep in Spain died in 2008 in the wake of a compulsory multiple vaccine campaign against bluetongue in Spain in 2008, Lujan set out to find out what killed them – and he began by inoculating them with aluminum.

His 2013 study found that only 0.5% of sheep inoculated with aluminum vaccines showed immediate reactions of lethargy, transient blindness, stupor, prostration and seizures – “characterized by a severe meningoencephalitis, similar to postvaccine reactions seen in humans.”  Most of them recovered, temporarily, but postmortem exams of the ones who didn’t revealed acute brain inflammation.

The delayed onset “chronic” phase of the disease affected far more of the sheep — 50-70% of flocks and sometimes virtually 100% of animals within a given flock, usually including all of those who had previously recovered. The reaction was frequently triggered by exposure to cold and began with restlessness and compulsive wool-biting, then progressed to acute redness of the skin, generalized weakness, extreme weight loss and muscle tremors, and finally, entered the terminal phase where the animals went down on their front quarters, became comatose and died. Post-mortem examinations revealed “severe neuron necrosis” and aluminum in the nerve tissue.

The immune system’s reaction to aluminum “represents a major health challenge,” Gerhardi declares in his recent review, and he adds that “attempts to seriously examine safety concerns raised by the bio-persistent character and brain accumulation of alum particles have not been made… A lot must be done to understand how, in certain individuals, alum-containing vaccines may become insidiously unsafe.”

Back to the problem of which “certain individuals” should avoid vaccination to avoid autoimmune disease.

PEOPLE PRONE TO DEVELOP AUTOIMMUNITY

Soriano and Shoenfeld’s identify a final category: anyone at risk of developing autoimmune disease. Since a number of them have been shown to have genetic factors that would include anyone with a family history of autoimmune disease. It also includes anyone who has tested positive for autoantibodies which can indicate disease years before symptoms show up.  Vaccinations, the doctors say, “may trigger or worsen the disease.”

Smokers too, have an exceptionally high risk of developing an autoimmune disease, says the report. The American Cancer Society estimates that about 18% of Americans smoke. That means about 42 million Americans have an elevated risk of developing an autoimmune disease and they’re stacking the odds with every vaccine.

And finally, factors that Shoenfeld and Soriano associate with high risk of developing autoimmunity are high estrogen and low vitamin D —  which means anyone taking birth control or hormone replacement therapy and, according to one 2009 study of vitamin D status, about three quarters of American teens and adults should be wary of vaccines.

Shoenfeld doesn’t seem to mean to exclude all of these people from immunization, however. The paper concludes that “for the overwhelming majority of individuals, vaccines carry no risk of systemic autoimmune disease and should be administered according to current recommendations.” Which is in stark contrast to the body of the paper. The final word is cautionary about weighing the “potential benefit of vaccination…against its potential risk.”

It’s exemplary of a strange sort of schizophrenia in a wide range of recent immunology papers. The doctors seem to be trying to reconcile a century of “safe and effective” vaccine dogma with the last decade’s worth of terrifying research findings. There’s a lot of “on the one hand” and “on the other hand” in them.

The new research seems about to gain the upper hand, however. A 2013 overview of ASIA by six immunologists including Shoenfeld, for example, is a catalogue of vaccine side effects from Gardasil deaths, narcolepsy epidemics, infertility, chronic fatigue, dead sheep and aluminum-addled brains. It is rife with statements that would have been virtually unheard of inside mainstream medicine a decade ago. Like this shocker:

“Perhaps, in twenty years, physicians will be dueling with better characterized particles of autoimmunity, and the vaccines may become fully safe as well as effective. Nonetheless the recognition of ASIA has initiated the change to put more efforts in identifying the good, the bad and the ugly of vaccines and in particular of adjuvants as triggers of autoimmunity.” Bad and ugly of vaccines? What’s wrong with the adjuvants? That’s not in the CDC hand-out.

Or how about this one:

“Despite the huge amount of money invested in studying vaccines, there are few observational studies and virtually no randomized clinical trials documenting the effect on mortality of any of the existing vaccines. One recent paper found an increased hospitalization rate with the increase of the number of vaccine doses and a mortality rate ratio for 5-8 vaccine doses to 1-4 doses of 1.5, indicating a statistically significant increase of deaths associated with higher vaccine doses. Since vaccines are given to millions of infants annually, it is imperative that health authorities have scientific data from synergistic toxicity studies on all combinations of vaccines…” That could be any anti-vaxxer jabbering on…but it’s not.

But here is the topper:

“The US Supreme Court ruled that vaccines makers are immune from lawsuits charging that the design of the vaccine is defective. Thus there is need for innovative clinical trial design and the vaccines themselves should be redesigned.” Immunologists including the world’s leading authority on autoimmunity are saying it is time to take vaccines back to the drawing board.

Autoimmune disease is the third leading cause of morbidity and mortality worldwide and now among the top 10 killers of young American women.  The American Autoimmune Related Diseases Association estimates that 50 million Americans suffer from one of 88 autoimmune diseases — from type 1 diabetes to systemic lupus erythematosus — and some research puts the figure at one in five globally. At least 40 more diseases are suspected to be immune-mediated. Most of them are devastating — frequently crippling, expensive to treat and incurable. And they are increasing at an astonishing pace.

At this stage, it looks like the more the research pours in, the harder it is going to get for pro-vaccine immunologists to keep multiple personality disorder – or complete nervous breakdown  — at bay. Ten years of cutting edge research into aluminum’s effects on the immune system has revealed primarily how wrong they were. And how little they know.  If, after 90 years, doctors finally have begun to seriously examine the mechanism and question the merits of injecting metal toxins into newborn babies, what have they yet to discover? ASIA sounds awful. (Too bad for all the people whose kids suffered through chronic fatigue when it was just a Freudian yearning to sleep with their mother.) But what if, like Lujan’s sheep, the “negligible” minority that has been paying the price for the good of humanity is actually only the tip of the iceberg? What if some people with no apparent adverse immune reactions still have nanocrystals of aluminum silently depositing in their brains? What if ASIA really includes Alzheimer’s? ALS, autism? ADD? And that’s just the A’s.

Even if immunologists keep wearing their rose coloured glasses, and vaccine ingredients are only responsible for a tiny fraction of the exploding autoimmunity, the “ugly” in vaccines will still get harder and harder to ignore. When everyone on the planet is getting injected, 20 years is a long time for disabled people to stack up while scientists “duel with the characterized particles of autoimmunity.” In the fury over the Disneyland measles outbreak that is gripping the world’s vaccine promoters, time is running out for doctors and researchers who see the “bad and ugly” side of vaccines and their adjuvants to do something about it. There’s slim chance of a vaccine redesign in the absence of a profit incentive and a strong chance of universal vaccine mandates for one and all — previous anaphylactic shock reaction or not.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

The Remarkable Benefits of Low-Dose Naltrexone


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2020/11/29/low-dose-naltrexone-benefits.aspx
Analysis by Dr. Joseph Mercola      Fact Checked      November 29, 2020

INTERVIEW WITH DR. SARAH ZIELSDORF AND LINDA ELSEGOOD:
Dr Mercola’s Video Interview
Download the Interview Transcript

STORY AT-A-GLANCE

  • Low-dose naltrexone, an opiate antagonist, can benefit most autoimmune and chronic pain conditions
  • LDN is also being used as an adjunct for cancer. Research by professor Angus George Dalgleish and Dr. Wei Lou showed LDN could bring cancer cells into remission using pulsed dosing
  • When microdosed, LDN can help potentiate long-term users of opioids, allowing them to reduce their dependence and lower their required opioid dose
  • Naltrexone only briefly blocks the opioid receptor. Its chief clinical benefit is in the rebound effect, which includes an upregulation of your immune system and subsequent reduction in inflammation
  • Other conditions being treated with LDN include Lyme disease and its co-infections, fibromyalgia, SIBO, restless leg syndrome, depression, dermatological issues and even infertility

In this interview, we review some of the remarkable benefits of low-dose naltrexone (LDN), including the surprising benefits of microdosed LDN. The two experts featured in this interview are Linda Elsegood, a Briton who founded the LDN Research Trust1 in 2004, and Dr. Sarah Zielsdorf, who has a medical practice in the Chicago area in the U.S.

Elsegood, who was diagnosed with MS in 2000, has been involved in LDN research and public education for 16 years. LDN is a powerful, safe and effective treatment for many autoimmune diseases, yet few, including most health care professionals, know anything about it. Remarkably, LDN may even be helpful in the fight against COVID-19, as it acts to normalize your immune system.2

Elsegood recently published a book on LDN called “The LDN Book, Volume Two: The Latest Research on How Low Dose Naltrexone Could Revolutionize Treatment for PTSD, Pain, IBD, Lyme Disease, Dermatologic Conditions and More.” Each chapter is written by a medical professional with clinical knowledge of the drug’s use. Zielsdorf is one of the contributing authors. Elsegood also hosts a radio show called The LDN Radio Show.3

In the interview, she tells the story of how she discovered LDN and the dramatic benefits she has experienced from it. In summary, beneficial effects became apparent after about three weeks on the drug and, after 18 months, her condition had significantly improved.

We use LDN for nearly all autoimmune conditions, as an adjunct for cancer, and as a treatment for chronic pain. We also use ultra-low dose naltrexone to help potentiate pain relief for people who are on opioids and help them to be less dependent on opioid medications. ~ Dr. Sarah Zielsdorf

Zielsdorf — who has an undergraduate degree in microbiology and a master’s degree in public health microbiology and emerging infectious disease — also has a personal health story that brought her to LDN. She was diagnosed with hypothyroidism (underactive thyroid) in 2003. Ten years later, she was diagnosed with Hashimoto’s, an autoimmune disorder that affects the thyroid.

“I learned about functional nutrition and triggers for autoimmunity, and started to do all of the things I needed to do to optimize my biomarkers, remove systemic inflammation, and was able to return to my [medical] training. I had been told that I could never have children and surprisingly became pregnant and had a daughter in my second year of training.

After having her, I [had a flareup]. It was then, in 2014, that a doctor put me on LDN. It changed my life … Once I graduated from residency, I started treating patients with a variety of issues with LDN. I’ve treated thousands of patients with LDN.”

Naltrexone — A Rare Gem of a Drug

Naltrexone in low or even microdoses is one of the few pharmaceutical drugs I wholeheartedly endorse. Not only is it remarkably safe, it’s also a profound adjunctive therapy for a wide variety of conditions. As explained by Zielsdorf:

“Naltrexone is one of the few things that actually enables our own bodies, our own immune systems, to be able to function better and really restore function.

After World War II, they were looking for more opioid medications. By accident, scientists figured out how to block the opioid receptor. They did the exact opposite of what they were supposed to do, which is to find morphine analogs for soldiers.

[In] the 1960s, they were able to synthesize naloxone and naltrexone … FDA approved it in the 1980s for opioid addiction at a dose of 50 to 100 milligrams, and then in the 1990s for alcohol dependence.

But it was Dr. Bernard Bihari and Dr. Ian Zagon in the 1970s that had this amazing idea that if you took a very small dose of naltrexone, compounding it in a clean way [down] to a few milligrams, if would briefly block the opioid receptor in the central nervous system — very briefly kissing that receptor and then unblocking it.

This upregulates the body’s immune system by increasing the opioid receptor’s own production of beta-endorphin and met-enkephalins. Beta-endorphins help with mood, pain, sleep and the immune system, and met-enkephalins are also known as opioid-derived growth factor, and there are receptors for these on many different tissues, including the thyroid.

We now use it for nearly all autoimmune conditions, as an adjunct for cancer, and as a treatment for chronic pain. We also use ultra-low dose [microdosed] naltrexone, which I wrote about, to help potentiate pain relief for people who are on opioids and help them to be less dependent on opioid medications.

I’ve actually been able to get patients off of fentanyl patches and get them off chronic oxycodone or Norco use where their pain specialists said, ‘You will never ever get off these pain medications.’ It’s been an incredible journey and I’m a huge advocate of it.”

Naloxone Versus Naltrexone

Naloxone (Narcan) is what is carried on ambulances and used in ERs and trauma bays as an antidote to an opioid overdose. When given at a high enough dose, naloxone or Narcan acts as a complete opioid blocker, which is why it’s used acutely when someone has taken too high a dose of an opioid.

Naltrexone blocks the opioid receptor only briefly, and by a different mechanism. When used in low dosages as LDN, the chief benefit is actually in the rebound effect, after the opioid receptor has been briefly blocked.

Foundational Treatment Strategies for Autoimmune Diseases

With regard to autoimmune diseases, it’s important to realize there are other, equally important, foundational strategies that will benefit most patients with a dysfunctional immune system. These include optimizing your vitamin D level and omega-3 index, for example.

It’s also important to eliminate potential triggers. The reason why people have an autoimmune disease is because they’re exposed to something in the environment which serves as an antigen that their body recognizes as a foreign invader, and as a result attacks it. If you can avoid those antigens, you can often suppress and frequently eliminate symptoms without anything, because you’ve removed the stimulus.

One common autoimmune trigger is lectins, found in many otherwise healthy vegetables. Zielsdorf will typically place her autoimmune patients on a Mediterranean-style paleo diet or an oligoantigenic elimination diet to optimize detoxification, liver and kidney function, and the microbiome.

Others may be placed on a nose-to-tail carnivore diet. As noted by Zielsdorf, it’s “a way of offloading and simplifying what antigens the body is seeing.” Other helpful diets in this respect include the autoimmune paleo diet and the low-histamine or low FODMAP diet.

“I am a microbiologist and I do a ton of advanced testing, and then we start looking deeper at triggers,” she says. “I used to put everybody on LDN first, but now we know that certain patients will flair because their immune system is so suppressed due to co-infections.

We see it most with Lyme disease and with yeast overgrowth. If I suspect or I have tests confirming that a patient has one of these things, or their immune system is super suppressed … I’ll work on their microbiome before I start LDN …

I test everybody’s gut, and what I see universally is you get this hyper intense intestinal permeability in these cases … What’s so interesting is a leaky gut equals a leaky brain, and we overwhelm our immune system. I do see this. The first step is getting them off the most common triggers, and sometimes I’ll be testing for lectins too.

Universally, for all of my autoimmune patients, is that they can’t eat wheat. There are over 150 antigens in wheat that you can be sensitive to … It is also desiccated with Roundup, glyphosate, right before processing, so we get that extra toxicity. I test my patients for their environmental toxic load, and I see a lot of patients with glyphosate toxicity.

The wheat that we used to eat 10,000 years ago at the beginning of agriculture is not the wheat [we now eat]. It’s not even the same chromosome number as what our bodies ate in small amounts as hunter gatherers.”

Why You Should Avoid Monogastric Animal Meats

As mentioned by Zielsdorf, a nose-to-tail carnivore diet can be an excellent intervention in some cases, especially for those whose immune function is severely suppressed. However, you should avoid monogastric animals, meaning animals that have only one stomach.

Whereas cows have two, chickens and pigs have only one. The reason for this recommendation is because conventionally factory farmed chicken and pork will be very high in the omega-6 fat linoleic acid. This is because they are typically fed corn, which is high in this type of fat. And a high linolenic acid diet can metabolically devastate your health. So, a diet high in chicken and bacon is not doing your body any favors.

Animals with two stomachs are able to fully process omega-6-rich grains and other foods, as they are equipped with gut bacteria that can break it down into a healthier fat. Aside from cows and steer, this includes buffalo, beef and lamb.

What Can LDN Treat?

Aside from autoimmune diseases, LDN is also used in the treatment of the following conditions. Bear in mind this is not a complete list. Some of these conditions have been featured in various documentaries4 produced by the LDN Research Trust. You can find links to those documentaries in the references.

Cancer5 — Research by professor Angus George Dalgleish and his colleague Dr. Wei Lou showed LDN could bring cancer cells into remission using pulse dosing.6 LDN also works synergistically with cannabidiol (CBD), and works well for cancer, autoimmunity and pain conditions
Opioid addiction, dependence and recovery7 — Using microdoses of 0.001 milligrams (1 microgram), long-term users of opioids who have developed a tolerance to the drug are able to, over time, lower their opioid dose and avoid withdrawal symptoms as the LDN makes the opioid more effective.

For opioid dependence, the typical starting dose is 1 microgram twice a day, which will allow them to lower their opioid dose by about 60%. When the opioid is taken for pain, the LDN must be taken four to six hours apart from the opioid in order to not displace the opioid’s effects

Lyme disease and its coinfections8
Fibromyalgia
Small intestinal bacterial overgrowth (SIBO)
Restless leg syndrome
Depression
Dermatological issues
Infertility

General Dosing Guidelines

Dosing will, of course, depend on the condition being treated, but there are some general guidelines that can be helpful. Downloadable guides can be found on the LDN Research Trust site, and are available in several languages. Keep in mind that LDN is a drug, not something you can buy over the counter, and you need to work with a knowledgeable physician who can prescribe it and monitor your health.

“With a general pain condition, we may use 1.5 to 3 or 4.5 mg. With Hashimoto’s, we start lower and slower because patients with Hashimoto’s may actually have to reduce their thyroid hormone medication if they’re on it because they get reduction of that inflammation and they can produce more of their own thyroid hormone. So, we usually start at 0.5 mg.

For patients with mood conditions … 0.5 to 1 mg. There was an important paper that came out showing LDN is an important agent for depression, for patients who fail those meds or as an adjunct to antidepressants. PTSD patients may have to go higher. There are all sorts of strategies and you just need to find a doctor who’s well-versed in that condition.”

More Information

The LDN Research Trust’s website is an excellent resource for all things LDN. It has a variety of resources to guide patients, prescribing doctors and pharmacists alike. It also has a page where you can find LDN-literate prescribers around the world.

Of course, to learn more, be sure to pick up a copy of “The LDN Book, Volume Two: The Latest Research on How Low Dose Naltrexone Could Revolutionize Treatment for PTSD, Pain, IBD, Lyme Disease, Dermatologic Conditions and More,” and/or “The LDN Book: How a Little-Known Generic Drug ― Low Dose Naltrexone ― Could Revolutionize Treatment for Autoimmune Diseases, Cancer, Autism, Depression and More,” which is the first of the two volumes.

Both books are also available on the LDN Research Trust website, along with videos featuring all of the doctors that contributed chapters to the books. You can also check out The LDN Radio Show.9 Last but not least, LDN Research Trust is a nonprofit that depends on public donations, so if you would like to contribute to the Trust’s LDN research and education efforts, please make a donation.

Daily dose of baking soda may help combat autoimmune disease

Reproduced from original article:
www.naturalhealth365.com/autoimmune-disease-baking-soda-3415.html

by:  | May 25, 2020

autoimmune-disease(NaturalHealth365) According to the National Institutes of Health, over 23 million Americans currently live with some type of autoimmune disease – which can encompass such potentially debilitating conditions as rheumatic arthritis, lupus, irritable bowel disease, type 1 diabetes, psoriasis, multiple sclerosis and Hashimoto’s thyroiditis. Autoimmune diseases – which arise when the immune system mistakenly attacks the body’s own organs, tissues and cells – are notoriously complex and difficult to treat.

But encouraging research shows that a common, familiar household staple – baking soda – can function as a potent weapon against them.

A recent study not only revealed baking soda’s ability to fight autoimmune disease – but showcased its ability to work at the cellular and molecular level.  For a lowly cooking ingredient, baking soda seems to have some highly sophisticated and powerful effects!

Can baking soda help those suffering with autoimmune disease?

Baking soda, also known as bicarbonate of soda, has a variety of household and medical uses.

It has long been used as a natural toothpaste, a non-toxic deodorant and a cheap, quick-acting antacid to treat heartburn. In addition, some nephrologists advise small daily doses of baking soda to slow the progression of chronic kidney disease.

After clinical studies affirmed baking soda’s beneficial effects on chronic kidney disease, researchers wondered what other conditions it could improve.  And they soon had their answer.

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In a study conducted by scientists at Medical College of Georgia at Augusta University and published in April 2018 in Journal of Immunology, the team found that drinking baking soda in water every day for two weeks helped to reduce the destructive inflammation of autoimmune disorders.

The key to baking soda’s action was the way it affected mesothelial cells on the exterior of the spleen. These specialized immune cells have microvilli that sense the environment and warn when an immune response is needed in order to defend against invading pathogens.

But in autoimmune disorders, this response can be inappropriate, excessive and damaging.

Baking soda helped the cells to convey the message that a protective immune response need not be triggered. In the words of study co-author Dr. Paul O’Connor, the compound helped reassure the immune system that there was no pathogen to be fought. “It’s most likely a hamburger, not a bacterial infection,” explained Dr. O’Connor.

It’s official: Baking soda reduces the inflammatory actions of cells

Bicarbonate of soda also affects the population of immune cells called macrophages, which engulf and destroy pathogens.  The scientists found that it shifted the macrophage population to a higher percentage of anti-inflammatory M2 macrophages, while decreasing pro-inflammatory M1 macrophages.

Although the initial research was conducted on rats, the researchers studied healthy human volunteers as well.  And these human participants also experienced an anti-inflammatory response from the baking soda.

In addition, the group who took baking soda had more inflammation-regulating T cells, which discourage the immune system from attacking tissue.

The researchers concluded that baking soda was a “cheap, relatively safe, effective and … noninvasive method to activate cholinergic anti-inflammatory pathways, which may be of benefit to patients suffering from a multitude of inflammatory disease states.”

In a separate study published in Proceedings of the National Academy of Sciences, researchers found that baking soda could specifically benefit rheumatoid arthritis – an autoimmune condition. The scientists concluded that baking soda and water helped reduce inflammation and disease severity.

Baking soda’s antiviral effects are currently being studied

Scientists have found that certain pH-dependent viruses – which happen to include some influenza viruses and coronaviruses – are most able to replicate and spread under acid conditions (pH6.0) and are deactivated completely at pH 8.0.

Baking soda raises acidic pH to higher alkaline levels – a fact with exciting implications for possibly slowing the spread of COVID-19 and other viral infections. While clinical studies have yet to be performed, cell and animal studies attest to the effects of alkalinity on viruses.

In fact, baking soda has been used to fight a pandemic in the past.  In 1918 and 1919, Dr. Edward R. Hays – a physician with the U.S. Health Department – utilized baking soda against the Spanish flu, claiming that it could lead to a resolution of symptoms within 36 hours.

In addition to antiviral and inflammation-fighting effects, baking soda can improve general health in myriad other ways.  According to noted doctor and author Dr. Eddy Bettermann, baking soda increases bicarbonates in the blood – in turn increasing carbon dioxide and helping with oxygenation of body organs.

And Dr. Lynda Frassetto of the University of California notes that baking soda can reduce acidic wastes in the body – which show up as cholesterol, fatty acids, uric acid, phosphate and kidney stones.

How much baking soda should I take?

While the University of Georgia scientists did not reveal the daily amount of baking soda used in the study, many natural health experts recommend half a teaspoon of baking soda dissolved in a cup or two of water a day.

Of course, check with your doctor before using baking soda to treat kidney disease, autoimmune disorders or any other medical condition. It is especially important to seek your physician’s guidance if you have high blood pressure, as baking soda is very high in sodium.

Health warning: To avoid possible gastric rupture, don’t take baking soda when your stomach is excessively full – such as after a huge meal.

While autoimmune disease can be a formidable foe, the simple, old-fashioned remedy of baking soda in water may emerge as a front-line defense against it.

Sources for this article include:

Jagwire.Augusta.Edu
DrEddyMD.com
Sciencedaily.com

76 Evidence-Based Health Benefits of Noni

© 3rd January 2020 GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here www.greenmedinfo.com/greenmed/newsletter
Reproduced from original article:
https://www.greenmedinfo.com/blog/76-evidence-based-health-benefits-noni
Posted on: Friday, January 3rd 2020 at 4:15 pm

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

Vitamin D3

Written by Brenton Wight, Health Researcher
Copyright © 1999-2021 Brenton Wight. All Rights Reserved
Updated 24th December 2020

Health Facts on Vitamin D3 – the Natural Cure for all disease!

Why we need Vitamin D3
First, to help absorb calcium and other minerals to build strong bones with the help of Vitamin K2 that keeps calcium in bones instead of in blood where calcium plaques form.
Second, to build the immune system, in conjunction with gut bacteria – the other half of the immune system story.
Depending on which study we believe, optimal vitamin D3 can prevent between 50% and 90% of all cancers, as well as Multiple Sclerosis, and reduce the intensity or even cure almost every other disease.
If a drug company developed something that would do this, it would make headlines around the world and win a Nobel prize, and many billions of dollars would be saved in the health care budgets of countries everywhere.
If the entire population had optimal Vitamin D3 combined with a healthy diet, countless lives would be saved from cancer, many illnesses would disappear, most artificial replacements of hips and knees would not be required, thousands of people clogging up the nursing homes in their wheelchairs would be out playing tennis and leading active, productive lives.
Have I convinced you yet that just a few dollars for a year’s supply of super-strength 5000 IU Vitamin D3 would be a good investment in your future?
If not, then perhaps you should go and reserve that spot in the nursing home, and pick out the burial plot while you’re at it!

Benefits of Vitamin D3

Studies show that Vitamin D3 has cancer inhibiting properties, especially breast, prostate, pancreas, colon, skin cancer and leukaemia.
While millions are spent trying to find a cure for cancer, Vitamin D3 could be used to prevent cancer in the first place, at a cost equivalent to a drop in the ocean.
Vitamin D3 deficiencies can cause the following:
Colds and flu:
Vitamin D3 helps prevent or reduce severity of colds, flu, and almost every other infection. LeanMachine is living proof. After 10 years of taking Vitamin D3, no colds, no flu, no infections of any kind, not even a headache!
When we look at studies funded by drug companies who manufacture vaccinations, which are always biased in favour of the flu shot, the NNT (Number Needed to Treat) for the flu vaccine is 40, meaning that to protect one person from getting the flu, 40 people must receive the vaccination. Compare this with Vitamin D3, where the NNT is 33 in the average population, and in those people with D3 deficiency, the NNT drops to 4. In other words, for the average person, D3 is significantly better than the flu shot, and for those with low Vitamin D3, D3 supplements work 10 times better than the flu shot!
Most infections are naturally destroyed by our own immune system, mainly by our T-cells, but T-cells need Vitamin D3 to operate correctly.
Studies funded privately, without the influence of the drug companies, have found the flu shot to be even less effective, with those over the age of 65, or under the age of 2, or those on statin medications, all receiving NO statistically discernible benefit from the flu shot, and everyone else receiving a very marginal benefit such as a reduction in duration of illness of about 1 day. Of course, a glass of lemon juice every day will also reduce the duration and intensity of all varieties of cold or flu by at least 1 day!
On the downside, those taking the flu shot every year received less benefit (less protection), and actually INCREASED risk of coming down with a different strain of the flu!
A further downside of the flu shot: During the Coronavirus pandemic, those who have the flu shot are 4 times more likely to contract COVID-19 AND to be hospitalised AND to die!
More on vaccinations under the heading below.
OA (Osteoarthritis)
Osteoarthritis (OA) is the most common disease in people over age 50, more common than the common cold, and especially in women.
OA is directly linked to Vitamin D3 deficiency, and higher Vitamin D3 levels lower the risk.
Studies show that hip fractures in high risk population groups can be reduced by up to 40% by supplementing with Vitamin D3.
Partly because bones are stronger, and partly because people with good Vitamin D3 levels have much better balance, stronger muscles and less body fat, so don’t fall over as much.

RA (rheumatoid arthritis) and MS (Multiple Sclerosis) appear to have the same link.

Obesity
Most Australians (two thirds) and others in Western society are overweight or obese.
Two thirds of people in Western society are also deficient in Vitamin D3, and this is no coincidence. There is a direct link between Vitamin D3 deficiency and obesity.
On average, the more Vitamin D3 deficient a person is, the more obese they are.
Healthy levels of Vitamin D3 are seen mainly in lean, healthy people.

Chronic pain
Chronic pain from any source can be reduced with Vitamin D3, even a simple headache, migraine, back pain, fibromyalgia, etc.
Many people with osteoporosis have chronic pain, typically lower back pain, often a sign of D3 deficiency.
Those people usually exercise less because of the pain, and insufficient exercise causes depression, worsens their osteoporosis, increases obesity, and their condition only gets worse.

Before 2010, LeanMachine suffered from headaches back pain and other pain, but no more. If I hit my thumb with a hammer, of course it hurts, and if I strain my back or another muscle, I feel stiffness that goes away in a day or two. But no other pain, no painkillers required, and in fact no painkillers of any kind kept in the house.

Cancer
Cancer is a devastating condition, but high levels of Vitamin D3 offer up to 80% or more protection, especially childhood cancers, breast, prostate, pancreas, skin and colon cancer.
A recent study confirmed that women with high levels of Vitamin D3 had about 85% reduced risk of breast cancer compared to those with the lowest levels of Vitamin D3.
Vitamin D3 is critical to the body’s production of GcMAF, a cancer-fighting protein that inhibits cancer metastasis, and is capable of reversing the devastating effects of cancer on the body. Vitamin D3 supports GcMAF synthesis, helping to shut down pro-cancer receptors and enzymes that encourage metastasis.
DBP-maf(Vitamin D3 binding protein-macrophage activating factor) is another protein reducing cancerous activity, which directly stimulates the immune response by suppressing angiogenesis (blood vessel growth) required for cancer cell migration and tumor growth. DBP-maf requires Vitamin D3 for transport in the bloodstream.

Depression
There are links between low levels of Vitamin D3 and depression.
For depression sufferers, LeanMachine recommends extra Vitamin D3 from sunlight because getting outside in the sun always lifts our mood. If we cannot get out in the sun, supplementation is a must.

Hearing Loss
Vitamin D3 deficiency weakens our bones, but when the three tiny bones (hammer, anvil and stirrup) in the ear become weak and spongy, attenuation of sound transmission results in hearing loss.

Allergies
Recent studies show that children with allergies have a high chance of being deficient in Vitamin D3, and those with the worst allergies, are over 80% likely to be deficient in vitamin D3.

Heart disease
The number one killer of Western society people is still cardiac disease.
Vitamin D3 deficiencies bring on high blood pressure, stroke and heart attack.
Number two is cancer, so we can alleviate both killers easily by eating a healthy diet and getting enough Vitamin D3 from sunlight and/or supplements.

Type 1 diabetes

Pregnant women who are deficient in Vitamin D3 are far more likely to produce offspring with Type 1 diabetes.
Any child deprived of sunlight in the first few years of life also has a far higher risk of type 1 Diabetes.

Diabetes
Studies show that vitamin D improves our body’s ability to use insulin, and tvitamin D is essential for stimulation of the pancreas beta cells to produce insulin.
Vitamin D receptors are in almost every cell in the body, triggering in all the target tissues for insulin, including organs, muscle and fat tissue.

A recent study by scientists involving nearly 500 patients found that 58% of those with a vitamin D deficiency also had insulin resistance. In fact, the lower their vitamin D, the greater their occurrence of insulin resistance.

In another study of 10,000 Americans over the age of 45, researchers found that boosting vitamin D levels reduced the incidence of diabetes, thanks to improvement in insulin function. Vitamin D also repairs damage to the heart and blood vessels caused by high blood pressure.

How do we get Vitamin D3?

We get Vitamin D3 from the sun, but we need the basic building-blocks in the body first.
The normal process of Vitamin D3 metabolism can be stopped by the deficiency of one single nutrient, so a healthy, nutrient-rich diet is essential.
In particular, we need cholesterol, which has been unfairly demonised for decades. More on this later.

Vitamin K2 – No Bones without it

Some people say we need Calcium for strong bones, but we get plenty of calcium from the diet, and we can absorb calcium with no problems as long as we have enough Vitamin D3.
Poor vitamin D3 means poor calcium absorption, so adding more calcium to the diet without vitamin D3 means potential for calcium to form as plaque in our arteries, kidneys or other places where it will only damage the body.
Vitamin K2, which comes from animal products such as chicken, cheese, butter, eggs, etc, can help build bones by directing calcium to bones and teeth where it belongs, and helps keep our arteries, kidneys and other organs free from calcium.
The only vegetable source of Vitamin K2 is Natto (fermented soy), which explains why Japanese post-menopausal women have much stronger bones than Western women, as Natto is part of the traditional Japanese diet.
Vitamin K2 is not to be confused with Vitamin K (or K1), which is required for effective blood clotting, but not as effective as Vitamin K2 for bones, but still desirable in the diet.
K1 comes from intestinal bacteria as well as from green leafy vegetables like kale, spring onions, brussels sprouts, cabbage, broccoli, basil, asparagus, also prunes.
For vegetarians or vegans, supplementation of Vitamin K2 is essential as well as vitamin D3 for healthy bones. Vitamin D3 metabolism is complex, where each essential and critical nutrient provides the path to the next step, and one missing link in the chain will stop the entire process.
So it is no surprise that a third of our population is deficient in Vitamin D3, and around 90% are less than optimal. Unfortunately, these are the people who are at the highest risk of cancer.

Importance of Diet

Vitamin D3 cannot form without basic nutrients for the multi-stage process and this explains why so many people are deficient.

D3 – A Vitamin or a Hormone?

The answer is both.
It is a hormone (a chemical messenger) because it controls cells, organs, muscle and bone in everyday function, and because the body can manufacture it with sunlight exposure on skin.
It is a vitamin because it binds calcium so we can absorb it, as we humans cannot digest calcium without Vitamin D3, which maintains calcium and phosphate concentrations in the blood, providing minerals for bones, nerves, muscles, immune function, and lowers inflammation.
Many cell functions are controlled in part by vitamin D3, aiding in weight loss, blood glucose regulation, metabolism, and essential fatty acids (Omega-3) processing.
There is no point taking calcium or omega-3 foods or supplements without a good supply of Vitamin D3.
Almost every cell in the body has Vitamin D3 receptors, so Vitamin D3 is a crucial nutrient.
Vitamin D, D2 or D3?
The terms Vitamin D and vitamin D3 are used interchangeably here. D3 is the correct and natural Vitamin D.
D3 exists in the body as the storage form 25(OH) and the active form 1,25 2(OH). Vitamin D2 (ergocalciferol) is an artificial version of Vitamin D3 (cholecalciferol), or vitamin D coming from some foods.
D2 has very low affinity for DBP (vitamin D binding protein) so it cannot be easily stored and should never be used.
Firstly, D2 has nowhere near the healthy properties of D3 (cholecalciferol), and secondly, D2 tends to block absorption of the real D3.
Many foods come “fortified with vitamin D” but this is invariably an artificial D2 with poor benefits.
Some early medical studies on vitamin D used inferior synthetic D2 which is toxic at much lower doses, and unfairly discredited the real D3 which was not even being used in the studies.

How is Vitamin D3 made?

We get vitamin D3 from sunlight, food or supplements.
D3 from sunlight
Most people know we get Vitamin D3 from sunlight, but there is a multi-stage process involved.
Production starts in the liver, which makes 7-dehydrocholesterol, which then migrates to the skin to be altered by UVB (ultra-violet light in the B range) to become pre-vitamin D3.
This is carried back to the liver to be mediated by an enzyme (25-hydroxylase) to become 25-hydroxyvitamin D, where a hydroxy (OH) molecule is added to build the storage form 25(OH).
This is then transported to the kidneys to be mediated by yet another enzyme (1-alpha-hydroxylase) to finally become calcitriol, where a second hydroxy (OH) is added. This is the active form of vitamin D3, also known as cholecalciferol or 1,25 dihydroxyvitaminD3 or the active form 1,25 2(OH). Dihydroxy means that the D3 molecule has two OH molecules added, one from the liver and a second from the kidneys.
Vitamin D3 is carried in the blood by DBP (vitamin D-binding protein).
This entire process takes around 15 days, so if we shower every day, we “wash off” most of the pre-vitamin D, so morning showers are best, allowing the pre-vitamin D to start the migration back to the liver before the next shower.
And a day at the beach won’t help our vitamin D3 if we go for a swim, and worse if we get sunburnt!

Statins rob our Vitamin D3

As we age, we lose the ability to synthesise vitamin D from sunlight, and those on statin medication (half the aged population) cannot make 7-dehydrocholesterol, co-enzyme Q10, Cholesterol Sulfate and other important requirements for the body, because when statins slow the liver production of cholesterol, all of the above are affected.
No one should ever take a statin drug (Lipitor, Crestor, Simvastatin and others) other than exceptional circumstances, as they generally do much more harm than good.
Independent studies show that while some deaths from heart disease are reduced, deaths from ALL OTHER CAUSES is INCREASED by statin medication! Taking statins, we will generally not live one day longer, and will have a poorer quality of life.
Also as we age, we generate less stomach acid, losing the ability to take in vitamin B12, Methyl Folate (never Folic Acid!), Vitamin K2 and other nutrients that vitamin D requires to do it’s job. If we get reflux or heartburn, doctors normally prescribe Nexium or antacids, which may relieve symptoms short-term, but only make the problem worse. The best way to cure heartburn is to eat less, and eat an alkaline-forming diet, but that is another story in my Alkaline Diet article.
Those who dress fully covered for cultural reasons or those with dark skin always need more vitamin D.
Annual blood tests for vitamin D3 are advisable if taken at very high doses as excess levels can become toxic.
For adults, toxic levels for vitamin D3 are generally not seen unless we take in some 40,000 IU daily for many weeks.
Vitamin A can also be toxic in high levels, but if vitamin A and vitamin D are taken together, the toxic levels are some 5 times higher for both A and D, giving a huge margin of safety, so old “toxic levels” should really be called “imbalance levels”.
Another factor is Vitamin K2, discussed later.

Other things that Steal our Vitamin D3

Being overweight – the more overweight we are, the less bioavailable Vitamin D3 becomes. But if we take Vitamin D3 supplements and/or get more sunshine, this will assist our weight-loss efforts!
Being old – as we age, our ability to absorb D3 from sunlight and from food reduces, so supplementation becomes more essential.
BPA (Bisphenol A) – BPA (Bisphenol-A) and other endocrine-disrupting chemicals reduce our Vitamin D3 levels. Avoid foods in plastic or cans and use glass containers.
Liver problems – a poor liver produces less bile, which reduces absorption of Vitamin D3. Look after the liver – avoid excess alcohol and eat a healthy diet of quality fats, few carbohydrates, and low to moderate protein.
Kidney problems – as kidney disease gets worse, so do Vitamin D3 levels. Look after kidneys by drinking plenty of clean water and eating a healthy diet
Gut bacteria – these 100 trillion organisms are a major component of our immune system, and also aid in absorption and processing of minerals and vitamins, including Vitamin D3. People with celiac disease, chronic pancreatitis, IBS (irritable bowel syndrome) or Crohn’s disease, or those taking antibiotics, will all have reduced D3, so essential supplements are Vitamin D3 and probiotics.
Slip, Slop, Slap in the face campaign – this disastrous campaign has been running for over 30 years in Australia, costing the taxpayer many millions of dollars, and has caused many more millions in extra health care, more disease, and many more lives lost.
True, reduced sunlight has reduced the number of mostly harmless skin cancers such as basal cell carcinoma and squamous cell carcinoma which are easily treated, and rarely turn into something more serious (less than 1% of cases).
But the number of MELANOMA cancers – the real, deadly kind, has DOUBLED, but this fact has been hidden by the Australian Cancer Council who are behind the Slip, Slop, Slap campaign! The primary reason, of course, is lack of Vitamin D3 due to reduced sunlight, reducing immunity.
Melanomas also appear on the soles of feet, in armpits and other places where sunlight is very limited, but so-called “specialists” still blame the sun!
The science cannot be denied. The closer one lives to the Equator, the less chance of any type of cancer, a proven fact.

Too much sunlight?

If we get D3 from sunlight, then surely if we spend all day in the sun, like construction workers and other outdoor activities, we should get plenty?
Wrong. After we spend around 10 to 20 minutes in the sun in the middle of the day (90 minutes for dark-skinned people), we reach a point where the body will no longer synthesise any more vitamin D3.
This is the way the body is designed to prevent toxic levels from building up, and also the reason why we get a tan – to prevent too much vitamin D3 from the sun.
If our skin starts to get the slightest shade of pink, it is time to cover up or seek some shade, as more sun will only then cause damage, with no extra vitamin D3 past that point.
And if we get a healthy dose of sunlight one day, we can happily work inside the next day, as it may take 2 days to build new skin resources for more absorption.

The Morning Myth

The cancer society and other “health” organisations all say the we should avoid the sun in the middle of the day, and only go out in the morning or the evening when the sun is low in the sky. Wrong again!
This is actually the complete reverse of the truth!
The sun produces ultra-violet rays in three bandwidths, named UV-A, UV-B and UV-C, each with different properties.
UV-A
We get UV-A from all sunlight, no matter what time of day, and it passes through cloud and glass, and this kind travels deeper into the skin, causes skin damage and ZERO vitamin D production.
We can sit by a window or in a car with windows up, on a hot sunny day and never get any vitamin D.
We can be outside all day when there is cloud cover, but we will never get any vitamin D.
All we get from UV-A is skin damage.
UV-B
We get UV-B ONLY from a clear blue sky, and ONLY when the sun is HIGH in the sky. This is the “good” sunlight, as this is the ONLY kind that gives us vitamin D.
When the sun is lower in the sky, most UV-B is absorbed in the atmosphere leaving little or none for our benefit.
We need 10 minutes a day (fair-skinned) to 20 minutes a day (tanned) with the sun high in the sky, no clouds, and no glass. This can give us all of the vitamin D we need, but for many, this is impossible.
For those living a long way from the equator, or out of the tropic areas in winter, those working shifts or indoors, those who cover their entire bodies for religious reasons, or slap on sunscreen, those who have very dark skin, those on statin medication, those on a poor diet, those confined to hospitals or nursing homes and others who mistakenly believe the sun is evil, will never get enough vitamin D.
Vitamin D is fat-soluble, meaning that if we get plenty one day and miss the sun for a few days, we will still be able to call on our vitamin D reserves stored in fat cells.
Of course, UV-B will still damage our skin if we stay out in the sun too long.
UV-C
UV-C rarely gets to Earth as it is almost completely absorbed in the atmosphere, so is of little concern unless you are an astronaut.

Why we NEED sunlight, more than just for Vitamin D3

The human body is designed to thrive in sunlight, and it is not only the Vitamin D3 benefit.
A 20-year study of over 29,000 people found that those avoiding sun exposure had double the death rate from all causes!
This study did not measure D3 levels, but results from other D3 studies show that the high death rate from insufficient sun exposure can not be accounted for only by low Vitamin D3.

We also get Cholesterol Sulfate from sunlight on the skin.
Cholesterol sulfate protects red blood cells from breaking up. Without enough cholesterol sulfate, we get a condition called hemolysis, where the red blood cells die prematurely, spilling their contents into the blood.
Without sulfur, and without the sun, we cannot make cholesterol sulfate, a molecule which is both fat-soluble and water soluble, which is essential for the body to distribute cholesterol and sulfur throughout the body.
All artery walls have an endothelial lining, and these endothelial cells cannot work correctly when depleted in sulfate. They cannot control what gets into and out of cells, which promotes cardiovascular plaque.
Cholesterol Sulfate, in conjunction with it’s nitric sister, eNOS, determines how thick or thin or blood becomes. Sulfate makes it thicker, nitric makes it thinner, and this automatic regulatory system works very well as long as we have supplies of both, for which we need sunlight.
Interestingly, one thing that messes up these molecules is glyphosate (“Roundup” and other weedkiller trade names) so this is a good reason to avoid all GM (Genetically Modified) foods, which are all heavily sprayed with glyphosate.
Sulfur is incredibly important for health. Cholesterol sulfate protects against bacterial and virus infections and strengthens the immune system.
Cholesterol sulfate is essential for babies. Women normally have about 1.5 units of cholesterol sulfate in the blood, but in pregnancy, levels rise in the villi of the placenta to around 24 units!
Foods high in sulfur include eggs, beef, garlic, onions, sprouts, asparagus, kale, coconut oil, olive oil, but only where they are grown or raised in sulfur-rich soil (think organic).

Vitamin D sulfate is also made from sunlight, and is both water and fat soluble, so it can go anywhere in the body, distinct from the regular fat-soluble Vitamin D3 I have been talking about. Same with cholesterol sulfate. Not only is it both water and fat soluble, it can travel through the body on it’s own, where many other substances need to be “carried” by cholesterol wherever they need to go.
If we want healthy blood, we MUST have sunlight!
Humans make several other important peptide and hormone “photoproducts” when skin is exposed to UVB sunlight:

  • β-Endorphins are natural opiates that induce relaxation and increase pain tolerance
  • Calcitonin Gene-Related Peptides are vasodilators (expand blood vessels) that protect us from hypertension (blood pressure), vascular inflammation, and oxidative stress
  • Substance P is a neuropeptide that increases blood flow and also regulates immune system response to acute stressors
  • Adrenocorticotropic Hormone is a polypeptide hormone, controlling cortisol (stress hormone) release by the adrenal glands, regulating immune system and inflammation
  • Melanocyte-Stimulating Hormone is a polypeptide hormone, reducing appetite, increasing libido, and increasing skin pigmentation

Sunlight contains a beneficial EMF (electromagnetic frequency) that is essential for health.
40% of sunlight is infrared, and the red and near-infrared frequencies interact with CCO (Cytochrome C Oxidase). CCO is a protein in the inner mitochondrial membrane, also part of the electron transport chain. CCO is a chromophore (a molecule that attracts and absorbs light), so sunlight improves ATP (the generation of energy). The optimal wavelengths for CCO are red at 630 nm to 660 nm (nanometers) and near-infrared at 810 nm to 850 nm.
LeanMachine gets sun exposure as often as possible. Others afraid of the sun may consider photobiomodulation therapy (use of near-infrared light treatment).
UVA exposure is generally considered harmful, as this is the most damaging kind of exposure for skin with no ability to generate Vitamin D, however there are benefits such as releasing NO (Nitric Oxide), discussed above. An important cellular signaling molecule that dilates blood vessels and reduces blood pressure.
This is closely tied to another molecule, eNOS (endothelial nitric oxide synthase) which regulates the “thickness” of blood. When blood becomes too thick, eNOS makes more nitric oxide which expands blood vessels and thins the blood. When blood is too thin, eNOS makes more sulfate. Sulfate is essential for the endothelial lining of all blood vessel walls. If we are low in sulfate, the wall can start breaking down and clots start to form to repair the damage. We can get more sulfur in the diet from onions, garlic, broccoli, egg yolks and other foods, or by supplements such as MSM (MethylSulfonoyl Methane) but we still need sunlight to make cholesterol sulfate which can be distributed through the body to keep us alive!

Apart from photoproducts, nitric oxide and cholesterol sulfate production, sunlight is essential for our circadian rhythm (body clock). Sunshine activates neurons in the suprachiasmatic nucleus of the hypothalamus, sending signals to the pineal gland which regulates production of the hormone melatonin. When the circadian rhythm is upset, melatonin and other hormone production is disrupted, leading to mood problems, poor cognition (thinking), metabolic syndrome (leads to diabetes) and increased risk of cancer.

Tanning Beds

Tanning beds are famous for increasing risk of melanomas, the most deadly form of skin cancer.
Tanning beds have been outlawed in all States of Australia, except in the Northern Territory, where they are still legal, but there are no commercial solariums there because the tropical climate makes sunlight tanning easy. However, this is seen by some as a knee-jerk reaction by politicians to win votes.
Most tanning beds produce UV-A and UV-B radiation, but some better units are available which produce only UV-B, which are much safer if used correctly.
Staying too long in even a quality tanning bed will cause skin damage, a precursor to many forms of skin cancer. Tanning beds that emit high levels of UV-A should be avoided completely.

Vitamin D3 from food

We get some vitamin D from the diet. Eggs, fish, cod liver oil are all good sources, and also come naturally with Vitamin A, but it is almost impossible to get enough D3 from the diet, so we must top up our D3 from sunlight or supplements or both. Milk contains some vitamin D, but calcium and vitamin D in milk are very poorly absorbed. Asian women are more likely than white women to be diagnosed with osteoporosis, so doctors claim this is caused by low milk consumption, but Asian women are much less likely to have a hip fracture (the worst kind), indicating that traditional DEXA scans (bone density tests) do not mean much, as dense bones are often not as strong as less dense but more flexible bones.
Africans generally have stronger bones than caucasians, even though they get less vitamin D3 from sunlight. They appear to be much more sensitive to the sunlight they do receive.

VitaminD3 from supplements

Most Vitamin D3 sold in Australia from chemist shops or supermarkets contain 1000 IU which may be enough to prevent rickets in young people, but is nowhere near optimum for immunity and bone strength, especially in older people, and not enough for anyone except small children to have an optimal immune system.
LeanMachine recommends Vitamin D3 5000 IU daily for almost a year’s supply, and this is the cheapest health insurance anyone can buy!
Vitamin K2 is also essential. Because Vitamin D3 increases calcium absorption, and Calcium can form part of blood clots, we need Vitamin K2 that has the ability to put calcium where it belongs, in bones and teeth, and reduces calcium buildup in blood vessels (arterial plaque).
Magnesium is also strongly recommended, because Magnesium and Vitamin K2 both work together with Vitamin D3 to increase the effectiveness of Vitamin D3 by about double.
Vitamin A is also recommended for health benefits as well as to eliminate any chance of toxicity.

No Cholesterol means no Vitamin D3

As explained above, cholesterol is the building-block for vitamin D3, also for every hormone in the body and many other functions.
About half the adult population over 60 in Australia and the USA is taking statin medication.
Sold under many names including Simvastatin, Lipitor, Advicor, Lovastatin, Mevacor, Vytorin, Zocor, Lipex, Simcor, Crestor, Pitavastatin, Pravastatin, Rosuvastatin, Fluvastatin, and Cerivastatin (withdrawn 2001).

The Lies about Cholesterol

Statins do lower cholesterol, but we NEED cholesterol, it is NOT the enemy it is made out to be. Yes, cholesterol is found in a badly inflamed body, but this is because the liver makes more cholesterol to repair damage caused by the inflammation, which is the REAL cause of poor health.
Statins reduce cholesterol by preventing the liver from producing as much cholesterol, but the job of the liver is to make cholesterol as required.
If we eat cholesterol foods (such as meat or eggs) the liver makes less, if we eat no cholesterol (such as a vegan diet), the liver makes more, which is the way it should be.
When statins are used, they attempt to shut down this natural process, and in so doing, also shuts down co-enzyme Q10 which is vital for healthy muscles.
And the heart is the most important muscle in the body – why clobber it with statins?
Statins also stop production of 7-dehydrocholesterol, so then we get almost zero vitamin D3 from sunlight.
Statins have shown no benefit to women whatsoever in many studies.
For men who have had a heart attack, statins have shown a slight reduction in deaths from future heart attacks, but in all patients, statins cause an INCREASE in deaths from all other causes!
Because statins knock out our Co-enzyme Q10 (often called the spark-plug for the heart), the patient can suffer extensive muscle damage, causing pain, reduced mobility and even death.
Drug companies say they have no idea what causes this increase in death from statins, but the answer is obvious to me – low vitamin D3!
Studies show that treatment with one fish oil capsule daily prevented 9% of deaths in cardiac patients over 4 years, while those given the Crestor statin drug had an INCREASED death rate of 1% over the same period.
The Framingham study, the biggest and longest study ever, showed that those with the lowest cholesterol died first, and those with the highest cholesteol lived longest!
But the drug companies continue to perpetuate these cholesterol lies to maximise profits from their biggest-selling drug.

How much D3 do we need?

The older we get, the more vitamin Vitamin D3 we need.
The only way to know how much we have is by a blood test, because ethnic background, skin colour, amount of tan, food, medication, supplements, geographic location, sun exposure, clothing, sunscreen, exercise, BMI and many other factors determine how much Vitamin D3 we absorb and retain.
Vitamin D3 is a fat-soluble vitamin, so daily levels do not vary much, as every fat cell in the body can store D3.
Always ask the doctor for a printed copy of your results so you can compare with any previous test and also get a true reading.
Unfortunately, most Australian labs say we need 60 to 160 nmol/L of D3, which is inadequate. Better labs say 75 nmol/L is the minimum, but we need more.
Values above 60 will prevent us from getting rickets, but will not give us good immunity.
For optimal immune system function, we should aim for the high end of the range of 125 to 175 nmol/L.
If we are battling cancer or some other serious disease, we should aim for 175 to 250 nmol/L but this requires careful monitoring and extra Vitamin K2 and Vitamin A to prevent toxicity.
Supplement values vary, and the RDA (recommended Daily Allowance) of 60 IU was alarmingly too low, and changed to 400 IU, originally determined as the minimum amount to prevent rickets.
Even the 400 IU allowance typically gives a blood test of 40 to 60 nmol/L which may barely stop rickets but will not provide a strong immune system.
Conservative studies determine that infants less than one year old need 400 IU daily, 1 year to adolescents need 400-600 IU daily, adults need 400-600 IU daily, and adults aged over 70 years need 400-800 IU daily.
More modern studies recommend babies take 400 IU, children 1000 IU, adults 4000 IU, and those over 70 may need 8000 IU daily.
Small doses are fine for strong bones, but for a strong immune system to ward off all disease, high doses are a must.
LeanMachine has taken 5000 IU daily for over 10 years, and has zero colds, flu or any other illness, not even a headache!

But don’t I get my Vitamin D3 from Milk?

Sorry, but you do not!
I was told to drink milk as a youngster, some 7 decades ago, and milk does indeed contain vitamin D and calcium, but these and other nutrients in milk are poorly absorbed in the gut.
Worse, pasteurised milk has most of the nutrients heated out of it, and homogenisation is very BAD for our health.
Homogenisation is a process making each fat globule 10 times smaller than normal, to save us the trouble of shaking the milk container to disperse the cream. The problem then is that these tiny fat globules then enter the bloodstream through imperfections in the gut lining, often referred to as “leaky gut syndrome”. When raw milk fat enters the blood directly like this, the immune system detects this as a foreign substance, and begins attacking these fat globules, and marks them as invaders. Now when we consume milk the regular way, and absorb it naturally through a healthy intestine, the immune system starts attacking this as well, as it has already been recognised as a foreign invader. The result: Allergies to Lactose, one of the main ingredients in milk, has reached epidemic proportions in the last few decades where homogenisation has become standard practice. Vitamin D3 can help moderate an over-reactive immune system, but the only safe way to drink milk is to only use NON-HOMOGENISED milk. Most supermarkets have it, but you have to look past the big-name brands to find it. Arnold Schwarzenegger famously said “Milk is for babies” and he was right.  Humans are designed to drink breast milk until age two, then lose the capacity to use it correctly in the body.
In many countries it is against the law to buy non-pasteurised milk, but we can at least buy non-homogenised milk if we feel we must have milk (and we do not need milk).
Some Asian countries have diets where milk is non-existent, and their bones are stronger, and broken bones are rare.
We get more useful Vitamin D3 from broccoli and other fresh vegetables than from milk!
Milk is also BAD for our bones, as it is acid-forming in the body, and all acids in the blood cause an immediate reaction in the body to neutralise the blood acid (otherwise we die!).
This reaction, controlled by the parathyroid glands, leaches potassium, calcium and magnesium from bones, teeth and organs, the fastest way the body can neutralise the acid.
If we must drink milk (and we do not have to for a healthy diet) then the ONLY milk to buy is FULL CREAM, UNHOMOGENISED milk, which you can find at good supermarkets if you look hard enough.
The only better product is the milk straight from the cow, or better still straight from mother’s breast (most mothers will not be impressed if you ask for milk this way!)

Getting enough of the right Vitamin D3

Sunlight is still the best way to get enough Vitamin D3 and Cholesterol Sulfate, but for many, this can be difficult or impossible.
Supplements are the next best choice, but the supplements we buy at Chemist shops or supermarkets in Australia have only around 1000 IU of Vitamin D3.
They are also often combined with Calcium, which LeanMachine does NOT recommend, but that is another story.
While this is better than nothing, most people require 5 to 10 times this much to bring their levels to “optimum”.
For most health specialists, “optimum” means over 60 or 75 nmol/l (30 ng/ml), and if your results come in at over this threshold, the doctor will say you are fine.
However, true experts in this field say that truly optimum for a normal healthy person for immunity to disease, is between 125 and 175 nmol/L (50 – 70 ng/ml).
For those recovering from a serious disease, optimum should be 175 to 250 nmol/L (70 – 100 ng/ml).
Vitamin D3 can be toxic at high doses for extended periods, so continuous levels over 250 nmol/L (100 ng/ml) should be avoided.
Blood tests are advised for all very high-dosage patients.
People most at risk of deficiency are the elderly, those with with dark skin, those who cover their body with clothing or sun screen, or work night shifts or underground and never see the light of day, and those who live furthest from the equator or in cloudy climates.
Those at risk may need 10,000IU daily supplements, the rest of us can usually get plenty with 5000IU, and the very young who get plenty of sunlight on a regular basis may not require any.
Remember that we only get Vitamin D3 from sun in a blue sky when the sun is high, from the UVB (Ultra-Violet light in the “B” range”).
When the sun is low in the sky, or when there is cloud, or when the light comes through a glass window, UVB is blocked and we only receive UV-A which is the damaging, cancer-causing radiation with Zero Vitamin D3 benefits.
Other tests: Depending on the condition, the doctor may order other tests to check for liver and kidney disease as well as a full blood count.
A full blood test for Vitamin D3 is:
25-hydroxyvitamin-D (25-D or D2/D3) or 25(OH)D or simply 25-D
1,25-dihydroxyvitamin-D3, or 1,25(OH)2 D3, or 1,25 2(OH), or simply 1,25-D
Most doctors will only test for 25(OH)D which is the storage form, which is fine for most people.
For those suspected of having Sarcoidosis (a rare condition) then both must be tested, and vitamin D supplementation and sunlight should be avoided altogether unless the active form 1,25(OH)2 is tested low.

Vaccinations

There are many reports of children suffering from Autism and other serious conditions after vaccinations.
Vitamin D3 supplements should be taken for at least 1 week before any vaccination to reduce risk of unfortunate reactions.
Panadol, Panadeine, Paracetamol, Tylenol, Acetaminophen, Atasol, etc must NEVER be taken before or after any vaccination, even though doctors incorrectly recommend it to reduce pain and fever.
Autism rates in the USA are 1 in 45, while Autism rates in Cuba are 1 in 12,000.
A few decades ago, Austism rates were only around 1 in 200, before Panadol (Tylenol, Acetaminophen in the USA)
Cuba has a high vaccination rate of 97%, but the difference:
These over-the counter pain medications are prescription-only items in Cuba.
Of course, no drug company is interested in conducting a study where the result may be that their “safe and effective” product causes Autism, but as far as LeanMachine is concerned, Vitamin D3 reduces the risk of sickness from almost any disease.
Besides Autism, Panadol can destroy liver function (most patients on the liver transplant waiting list are there because of Panadol), and Panadol is also acted upon by enzymes which then destroy the body’s reserves of L-Glutathione, the natural “Master Antioxidant” in the body.
If you want your child vaccinated anyway, DO give them vitamin D3 and DO NOT give them any pain or fever medication.
A little fever is the body’s way to fight the toxins in the vaccination and the best way to deal with it is to let it run it’s course.
However, a very high fever can lead to convulsions, especially in small children. The best way to bring down a very high fever is to place the child in a cool to lukewarm bath and keep water over the skin using a sponge or cloth.
No drugs required, and much safer and more effective than any drug.
Better still, vaccinations can be avoided altogether for those with a strong immune system.
For more information on vaccinations, see this article: Vaccinations.

Autoimmune conditions

Allergies, hives, arthritis, lupus, psoriasis, rheumatoid arthritis, thyroid disease, multiple sclerosis, etc, are all autoimmune conditions.
Little help is available from medications which merely help to ease symptoms.
Vitamin D3 builds the immune system and protects us from colds, flu and other diseases, but Vitamin D3 is also an Immune Moderator, helping to dampen the effect of the immune system over-reacting, the cause of auto-immune disease.
Vitamin D3 can also help treat the cause of the symptoms, often Helicobacter pylori (H. pylori), found in over 70% of autoimmune patients.
H. pylori can invade the gut via contaminated water or food, or from contact with infected people or animals, causing gut inflammation, disrupting the immune system.
Vitamin D3 effectively destroys H. pylori and restores the immune system, often reducing allergy symptoms by 30% in seven days, and another 40% in 12 weeks.
H. pylori infects around 30% of adults in the western world, more if we are over 60 with low Vitamin D3 levels.
A blood test can give your D3 levels, but the lab will say 60 to 75 nmol/L is OK, but we need 125 nmol/L minimum to destroy H. pylori.
Mushrooms, eggs, wild-caught salmon, etc have natural Vitamin D3 but the modern Western diet is lacking in these. Mushrooms grown in the dark will have no vitamin D3, but 30 minutes of exposure to direct sunlight can generate significant D3 levels.

Vitamin D3
The latest science Says: “It’s not just about bones, it’s about your total well-being!
Professor Michael Holick:
We now think that maintaining adequate Vitamin D3 levels are important for decreasing the risk of prostate cancer, breast cancer and colon cancer.
There is some evidence that in young children if they are fortified with vitamin D3 from 12 months old it can reduce the risk of type 1 diabetes by 80%“.
Professor Philip Sambrook:
We have always thought it could not happen in Australia – it is too sunny a country. However, people do not get sunlight for various reasons and if you do not get some sunlight you do not make vitamin D3. We do not get it much in food any more so for that reason, deficiency is quite common. And the vitamin protects healthy cells while also killing cancer cells.”

Disclaimer

LeanMachine is not a doctor, and everyone should consult with their own health professional before taking any product to ensure there is no conflict with existing prescription medication.
LeanMachine has been researching nutrition and health since 2010 and has completed many relevant studies including:

  • Open2Study, Australia – Food, Nutrition and Your Health
  • RMIT University, Australia – Foundations of Psychology
  • Swinburne University of Technology, Australia – Chemistry – Building Blocks of the
  • World
  • University of Washington, USA – Energy, Diet and Weight
  • Johns Hopkins Bloomberg School of Public Health, USA – Health Issues for Aging
  • Populations
  • Johns Hopkins Bloomberg School of Public Health, USA – International Nutrition
  • Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics I
  • Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics II
  • Johns Hopkins Bloomberg School of Public Health, USA – Principles of Human Nutrition
  • TUFTS University, USA – Nutrition and Medicine
  • TUFTS University, USA – Lipids/Cardiovascular Disease I and Lipids/Cardiovascular Disease II
  • Technical Learning College, USA – Western Herbology, Identification, Formulas
  • Bath University, England – Inside Cancer
  • WebMD Education – The Link Between Stroke and Atrial Fibrillation
  • WebMD Education – High Potassium: Causes and Reasons to Treat
  • Leiden University Medical Center, Netherlands – Anatomy of the Abdomen and Pelvis
  • MIT (Massachusetts Institute of Technology) – A Clinical Approach to the Human Brain

LeanMachine has now examined thousands of studies, journals and reports related to health and nutrition and this research is ongoing.

Copyright © 1999-2021 Brenton Wight and BJ&HJ Wight trading as Lean Machine abn 55293601285

Black Seed May Treat Hypothyroidism (Hashimoto’s Disease), Clinical Trial Reveals

© 14th September 2019 GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here www.greenmedinfo.com/greenmed/newsletter
Original article:
https://www.greenmedinfo.com/blog/black-seed-may-treat-hypothyroidism-hashimotos-disease-clinical-trial-reveals
Posted on: Saturday, September 14th 2019 at 7:15 am

This article is copyrighted by GreenMedInfo LLC, 2019

Black Seed May Treat Hypothyroidism (Hashimoto's Disease), Clinical Trial Reveals

A groundbreaking clinical trial indicates that the most common cause of hypothyroidism (Hashimoto’s disease) may be improved with the addition of only two grams of powdered black seed daily

A randomized clinical trial reveals that the ancient healing food known as nigella sativa (aka “black seed”), once known as the “remedy for everything but death,” may provide an ideal treatment for the autoimmune thyroid condition known as Hashimoto’s disease, which is the most common cause of hypothyroidism.

The study published in the journal BMC Complementary and Alternative Medicine evaluated the effects of nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) – 1, Nesfatin -1 and anthropometric features in patients with Hashimoto’s thyroiditis.

The study took 40 patients with Hashimoto’s thyroiditis, aged between 22 and 50 years old, and randomized them into one group receiving two grams of powdered encapsulated Nigella sativa and the other 2 grams starch placebo daily for 8 weeks.. Changes in anthropometric variables, dietary intakes, thyroid status, serum VEGF and Nesfatin-1 concentrations were measured.

The positive results were reported as follows:

“Treatment with Nigella sativa significantly reduced body weight and body mass index (BMI). Serum concentrations of thyroid stimulating hormone (TSH) and anti-thyroid peroxidase (anti-TPO) antibodies decreased while serum T3 concentrations increased in Nigella sativa-treated group after 8 weeks. There was a significant reduction in serum VEGF concentrations in intervention group. None of these changes had been observed in placebo treated group. In stepwise multiple regression model, changes in waist to hip ratio (WHR) and thyroid hormones were significant predictors of changes in serum VEGF and Nesgfatin-1 values in Nigella sativa treated group (P < 0.05).”

The researchers concluded:

“Our data showed a potent beneficial effect of powdered Nigella sativa in improving thyroid status and anthropometric variables in patients with Hashimoto’s thyroiditis. Moreover, Nigella sativa significantly reduced serum VEGF concentrations in these patients. Considering observed health- promoting effect of this medicinal plant in ameliorating the disease severity, it can be regarded as a useful therapeutic approach in management of Hashimoto’s thyroiditis.”

What is Hashimoto’s Disease and Why Does Synthetic T4 Fail To Improve Well-Being

Hashimoto’s disease can be a devastating condition, especially when treated with a conventional medical approach. Also known as chronic lymphocytic thyroiditis, it is a progressive autoimmune disease where, in the many cases, the thyroid gland is eventually destroyed. It is considered the most common cause of hypothyroidism in North America. Some additional salient facts are:

  1. About 5% of the U.S. population will be affected by Hashimoto’s thyroiditis at some point in their life.

  2. Hashimoto’s occurs up to 15 times  more often in women than in men. The highest density of Hashimoto’s cases are between 30 and 60 years of age.

  3. Postpartum thyroiditis occurs in about 10% of patients.

  4. Hashimoto’s related hypothyroid is often under-diagnosed because the reference ranges were drawn from an unscreened population likely inclusive of those already suffering from suboptimal thyroid function or outright dysfunction.

The standard of care is to ‘manage,’ or artificially suppress, modulate, and/or replace hormone levels. Hypothyroidism caused by Hashimoto’s thyroiditis is most commonly treated with synthetic T4 in an attempt to reduce TSH levels under 5.0 U/ml. This often results in the appearance of TSH normalization, with downstream adverse effects, and without concomitant improvements in well-being. Dr. Kelly Brogan, MD, further elaborates:

“For those who do receive the label of hypothyroid, they remain obliquely objectified by their lab work as their doctors use synthetic T4 – Synthroid – to attempt to move their TSH within range, more often leaving them symptomatic but “treated” because of poor conversion to active thyroid hormone (T3) and suppression of natural T3 production because of their now lower TSH.”

It should be noted that while synthetic T4 is described by its manufacturer to be “identical to that produced in the human thyroid gland,” it is in actuality quite different. This has to do primarily with the fact that while the primary structure of amino acids in synthetic thyroxine produced from genetically modified yeast is virtually identical to that produced by the human thyroid gland, the secondary, tertiary and quaternary folding patterns of that protein may differ in significant ways. Known as the protein’s conformational state, a slight change in folding structure can alter function profoundly. This could account for widespread reports of dissatisfaction among those treated with synthetic thyroid versus natural forms extracted from the glands of pigs.

Even if the T4 produced synthetically were identical in structure and function to natural T4, the reality is that virtually all T4 found naturally in the human body is not found in its free state.

Moreover, T4 is found inextricably bound together with T3, T2, T1, and calcitron, in the extraordinarily complex Thyroxine Binding Globulin (TBG) protein. Clearly, therefore, pharmaceutical preparations of isolated T4 can not be considered identical to whole-food complexed thyroid hormones derived from natural extracts.

In a post titled, “Natural Desiccated Thyroid and Synthetic are NOT the Same,” from thyroid-s.com, this point is driven home powerfully:

“To graphically illustrate the huge differences between Natural Desiccated Thyroid as compared to T4 Only Synthetics, please consider this graphic. It attempts to show the tiny T4, T3, T2, T1 and Calcitonin hormones tightly bound to the very large thyroglobulin molecules as found in Natural Desiccated Thyroid. Remember that the Thyroglobulin molecule is approximately 1,000 TIMES BIGGER than the T4 molecule. Then it also shows the tiny T4 molecules as found in synthetic T4 only products. The pharmaceutical companies would have us believe these are bio-identical. We will let you decide.”

Moreover, research published in 2010 in the Archives of Pharmaceutical Research shows that levothyroxine preparations are widely contaminated with a “mirror image” stereoismer called dextro-thyroxine at a level as high as 1-6% by dry weight. D-thyroxine violates the left-handed ‘chirality’ of natural thyroxine and is a powerful, cardiotoxic endocrine disruptor.

The process by which levothyroxine sodium is produced today is highly synthetic and involves the use of a wide range of chemicals. One patent describes the dizzyingly complex process as follows:

“The process for preparation of Levothyroxine sodium comprises the steps, wherein compound obtained from steps a-g is prepared by conventional methods, a. nitrating L-tyrosine to give 3,5- dinitro-L-tyrosine, b. acetylating 3,5- dinitro-L-tyrosine to give 3,5- dinitro-N-acetyl L-tyrosine, c. esterifying the compound obtained from step (b) to give 3,5- diπitro-N-acetyl L-tyrosine ethyl ester, d. reacting the compound obtained from step (c) with p-TsCI in presence of pyridine to give corresponding tosylate salt, which is further reacting with 4-methoxy phenol to give 3,5- DinKro-4-p-methoxy phenoxy-N-acetyl-L-phenyl alanine ethyl ester, e. the compound obtained from step (d) is hydrogenated to give 3,5-diamino-4-p-methoxy phenoxy-N-acetyl-L-phenyl alanine ethyl ester, f. the compound obtained from step (e) is tetrazotized and iodized to give 3,5-Diiodo-4-p- methoxy phenoxy-N-acetyl-L-phenyl alanine ethyl ester, g. the compound obtained from step (f) is O-demethylated, N-deacetylated, and deesterified using aqueous HI in acetic acid to give 3,5-Diiodo-4-p-hydroxy phenoxy-L-pheπyl alanine followed by preparing hydrochloride salt of same and isolating, drying it h. lodinating 3,5-Diiodo-4-p-hydroxy pheπoxy-L-phenyl alanine HCI salt using methyl amine,”

Clearly, synthetic T4 treatments, even if effective at suppressing TSH, may not produce clinical outcomes that translate into improvement in well-being. Nor do they address or resolve the root causes of Hashimoto’s, which include selenium deficiency, wheat intolerance, and vitamin D/sunlight deficiency [view studies on these links on our Hashimoto’s research dashboard], along with a wide range of still yet unknown environmental, dietary, lifestyle, and mind-body factors.  Perhaps this latest study on black seed provides a new avenue for mitigating and correcting the metabolic and endocrine factors that are disturbed in Hashimoto’s disease, or at least complementing conventional treatment with a food-based approach that can improve both the subjective and objective aspects of the disease.

For more information on natural and integrative approaches to thyroid disease visit the following resource pageson GreenMedInfo.com:

To learn more about the powerful health benefits of black seed visit our research dashboard on the subject: Nigella Sativa (aka Black Seed)

 

Originally published: 2017-03-12

Article updated: 2019-09-08

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.