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Investigation Finds Serious Flaws in Study That Served as Basis for Guideline Suspected of Killing Nearly a Million Europeans


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2014/08/13/flawed-research-beta-blockers.aspx
August 13, 2014

Prescription Drugs

STORY AT-A-GLANCE

  • European doctors may have caused as many as 800,000 deaths in five years by following the “standard of care” to use beta-blockers in non-cardiac surgery patients—a guideline based largely on discredited science
  • The discredited researcher, who was fired for scientific misconduct in 2011, was also the chairman of the committee that drafted the European treatment guideline
  • An investigation into the flawed study has now been completed, and while the full extent of the researcher’s scientific misconduct is almost impossible to ascertain, it appears to be extensive
  • Investigations assessing the prevalence of scientific fraud and/or its impact show that the problem is widespread and serious

By Dr. Mercola

Investigations assessing the prevalence of scientific fraud and/or its impact show that the problem is widespread and serious—to the point of making most of “science-based” medicine a genuine joke.

Conflict of interest is another pervasive problem that threatens the integrity and believability of most studies. We’ve been repeatedly faced with study findings that are clearly tainted with industry bias.

The soda industry’s study1, 2 finding that drinking diet soda makes you lose more weight than drinking no soda at all is just one of the most recent examples. It blatantly contradicts a massive body of research demonstrating that artificial sweeteners disrupt your body’s metabolism and lead to greater weight gain than regular sugar.

Earlier this year, I reviewed findings that a flawed research paper may have led to the death of as many as 800,000 Europeans. The discredited paper served as the basis for a guideline3 that helped establish the “standard of care” to use beta-blockers in non-cardiac surgery patients.

The study’s author, Dr. Poldermans, was also the chairman of the committee that drafted the guideline (he has since resigned from his position with the task force4).

Physicians who failed to follow this guideline were at risk of medical reprimands. This case is a sobering example demonstrating the need for maintaining strict scientific integrity, and why the issue of conflicts of interest really needs to be more widely understood and addressed.

Scientific misconduct can have a very real impact on your health, or someone you love, as doctors routinely use published research to implement or alter treatment protocols.

Investigation Finds Serious Flaws in Prestigious NEJM Study

An investigation into Dr. Poldermans beta-blocker study has now been concluded, and as reported by Forbes,5 the full extent of the misconduct is almost impossible to ascertain, although it appears to be extensive:

“Erasmus Medical Center says it has wrapped up its investigation of Don Poldermans, the disgraced cardiology researcher who was fired for research misconduct…

One major finding… is that the most prestigious and influential publication from the Poldermans’ group, the 1999 publication of the DECREASE 1 study in the New England Journal of Medicine6– appears to be riddled with serious problems…

The Dutch investigators found a number of important discrepancies between the trial conduct and the written protocol found in the archive of the Medical Ethics Committee. Poldermans told the investigators that there was an updated version of the protocol but this document has not been found.”

Another major problem is that while Dr. Poldermans claimed adverse events were evaluated by two cardiologists who allegedly made up the trial’s safety committee – both of them deny having any involvement in the study.

Only one of them could remember having been asked to participate, but claims he never actually did any evaluations. According to Dr. Poldermans, the two cardiologists had reviewed all patient data. He also claims that it was this two-man safety committee’s decision to end the trial early. According to the featured article:7

“One member said that he had given some advice to Poldermans by telephone about ‘stopping rules.’ Poldermans told the investigators that, contrary to the published report, the decision to stop the trial had been made by ‘the steering committee.’

Perhaps surprisingly, the report does not conclude that the trial is invalid. Instead, it concludes that doubts about the scientific integrity can neither be confirmed nor denied.”

The investigators also reviewed Dr. Poldermans extensive body of work, some 495 studies in all, trying to ascertain whether the studies actually took place. Lack of documentation and missing records hampered the investigation, suggesting Dr. Poldermans contribution to the field of medicine may indeed have been based on large-scale misconduct.

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Most Misconduct Occurs in Drug Research

Previous investigations8 have revealed that the vast majority of scientific misconduct occurs in the drug literature, compared to the biomedical literature. Three guesses as to why that might be, and the first two don’t count… Of course the answer is massive drug company conflict of interest and manipulation.

Two years ago, researchers at the University of Illinois at Chicago’s Center for Pharmacoeconomic Research found that nearly 75 percent of retracted drug studies were attributed to scientific misconduct, which includes data falsification, data fabrication, questionable veracity, and plagiarism.

Tragically, since these are the types of studies that many health care professionals rely on to make treatment recommendations, large numbers of patients can be affected when false findings are published.

This certainly appears to be the case here—nearly one million surgical patients losing their lives over a five-year span as a result of a hazardous drug guideline is pretty significant.

Vioxx is another example of what canhappen when a drug is manufactured and marketed under false pretenses. It killed more than 60,000 people in just a few years’ time, before it was removed from the market.

To this day there are lingering questions about the soundness of the research backing Vioxx. In 2008, Dr. Joseph S. Ross of New York’s Mount Sinai School of Medicine came across ghostwritten research concocted by the company’s marketing department,9 while reviewing documents related to lawsuits filed against Merck…

It’s important to understand that our current medical system has been masterfully orchestrated by the drug companies to create a system that gives the perception of science while in fact being a heavily manipulated process designed to sell expensive and potentially toxic drugs. The drug companies that make them benefit, while your health suffers.

Understanding the Potential Risks and Benefits of Beta-Blockers

Beta-blockers are drugs commonly used in the treatment of high blood pressure and congestive heart failure. They dilate your blood vessels, which reduces your heart rate and blood pressure.

Until recently, the European Society of Cardiology (ESC) recommended using beta-blockers in patients undergoing non-cardiac surgery as well, regardless of whether the patient had a heart condition.

The medical literature and media articles reflect ongoing concern and confusion about whether or not to use beta-blockers in non-cardiac surgeries. What the media are missing is that there are two different classes of patients, and the studies typically involve either one or the other—but rarely do they compare both.

When viewed in total, the research suggests that giving beta-blockers to non-cardiac surgery patients can have lethal consequences in people who do not have a pre-existing, serious, life-threatening heart condition.

In one study,10 perioperative use of beta-blockers showed that people who had the highest risk of dying from them were the ones with the lowest cardiac risk. In effect, they found that perioperative beta blockers may have helped those with the most serious pre-existing heart conditions, while harming those with little or no prior heart risks.11

Anytime drugs are involved, it’s important to understand and weigh the risks and benefits. In this case, in order for non-cardiac perioperative beta blockers to be of potential benefit, the risks associated with heart disease must outweigh the heavy risk and side effects of the drug itself, which covers a very limited target population. The moral of this story is that patients should push back to ensure the physician sees a definite need before prescribing this, or any other, drug. In this case, it appears that nearly a million Europeans with little or no need were given the drug as part of a routine guideline, and paid with their lives.

How Many Americans May Have Been Harmed by Similar Guidelines?

If the claim that beta-blockers may be killing some surgical patients — those who don’t already have serious risks for cardiac conditions, and who are not already on beta-blockers – what is the potential number of deaths in the US? Fortunately, according to a previous Forbes article12 published in July 2013, US guidelines are less aggressive in their support of perioperative beta blockers. Researchers say more than 30 million non-cardiac surgeries occur in the US each year,13 so if you divide 30 million by the 25 percent that European researchers claim may be harmed by this one-size-fits-all practice, you end up with a number of 7.5 million American surgery patients POTENTIALLY harmed by beta blockers each year. The numbers could be higher, or lower.

According to the CDC,14 the total number of surgical procedures performed in the US is 51.4 million, of which 4.7 million are cardiac-related. Using this statistic, the number of Americans potentially affected by dangerous beta-blockers is 46.7 million, giving us a potential number of more than 11.6 million who could die from this drug every year in the US. On the other hand, we don’t know how many already had a life-threatening heart condition prior to going in for non-cardiac surgery and might have benefited from the drug, opposed to patients whose risk of death is increased by the absence of prior heart disease…

Tragic Fact: Most Research Claims Cannot Be Trusted

In 2005, Dr. John Ioannidis, an epidemiologist at Ioannina School of Medicine in Greece, showed that there is less than a 50 percent chance that the results of any randomly chosen scientific paper will be true.15 So just think about this for a moment. You have a far better chance of tossing a coin and guessing correctly than you do for any random “scientific” paper is valid. This is extraordinary, especially since skeptics who regularly ridicule natural medicine use these studies as a justification for the vilifications.

Additionally, a large number of investigations have revealed that when industry funds the research, it’s virtually guaranteed to be favorable to their product. Other conflicts of interest play a significant role in the outcome as well. Did the fact that Dr. Poldermans was the chairman of the committee that drafted the beta-blocker guideline influence his research conduct? We don’t know, but there’s always a risk that hidden incentives can come into play with this kind of conflict of interest.

In recent years, a number of individuals have taken it upon themselves to prove just how easily the system can be fooled by fake science. A previous article in Slate Magazine16 headlined: “How Gobbledygook Ended Up in Respected Scientific Journals,” reveals how a group of MIT graduate students created a program that randomly generates computer-written research papers. Shockingly, these fake papers have been routinely published in various scientific journals over the past several years.17

No one knows exactly how many have been published as the creators of the program, called SCIgen, made it available for free download. An unknown number of people have used it18 besides its creators. Cyril Labbé, a French computer scientist developed a way to detect SCIgen generated manuscripts,19 and have alerted publishers about 205 of them so far. Confounding the problem further, highly paid PR firms disguised as scientific organizations have been created for the specific purpose of controlling how the media reports new science and portrays industry. Two examples are Science Media Centre (SMC) and the American Council on Science and Health (ACSH), both of which are heavily funded by the industries they represent.

Exercising Good Judgment in an Era of Conflicting Interests

Ultimately, the take-home message here is that even if a drug or treatment is “backed by science,” this does not guarantee that it’s safe or effective. Likewise, if an alternative treatment has not been published in a medical journal, it does not mean it is unsafe or ineffective. This is why it’s crucial to have a philosophical framework to assist you in evaluating all these studies. First, always consider the source of the information… Who funded the study and where it was published? Also, do not accept the findings of any single paper, as scientific results are only reliable after replication and the building of consensus through time. Look for corroboration.

Anytime you’re trying to address a health issue, make full use of all the resources available to you, including your own common sense and reason. Since it is well established that most drugs do absolutely nothing to treat the cause of disease, it would be prudent to exercise the precautionary principle when evaluating a new drug claim, as it will more than likely be seriously flawed, biased, or worse.

If you value your health and life, remember that prescription drugs kill more people than illegal drugs or motor vehicle accidents. Hypertension is dangerous if uncontrolled, increasing your risk for heart attack and stroke. But using drugs like beta-blockers to lower your blood pressure may shorten your lifespan instead of extending it. For recommendations on lowering your blood pressure without the use of drugs, please see my previous article, “Foundational Lifestyle Strategies to Maintain Healthy Blood Pressure.”

If you’re facing a health challenge, it is best to identify a qualified natural health consultant—someone who really understands health at a foundational level and has had extensive experience in helping others resolve their health care challenges. Just make sure to see a competent regular physician to make certain any serious conditions like cancer are ruled out as well.

Ditch Pharmaceuticals, Get Aspirin From Your Food


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2020/01/06/aspirin-health-effects.aspx

Analysis by Dr. Joseph Mercola Fact Checked image
aspirin health effects

STORY AT-A-GLANCE

  • Recommendations for once-a-day aspirin were pulled by the FDA when the risks of major bleeding far outweighed the benefits of preventing a heart attack. Salicylic acid, the active ingredient, is found in high concentrations in cumin
  • Eating one teaspoon of cumin in well-spiced foods spikes blood levels of salicylic acid as if you took a baby aspirin. Data show those eating foods high in salicylic acid may help lower their risk of developing certain cancers
  • Consider stimulating the vagus nerve, or 10th cranial nerve, to activate the parasympathetic nervous system and protect your heart
  • Nattokinase and lumbrokinase are two aspirin alternatives without high side effect profiles, which demonstrate the ability to improve circulation and reduce the risk of serious clotting

Aspirin has a long history, dating back nearly 4,000 years when Sumerians wrote of using willow bark for pain relief.1 The ancient Egyptians used willow bark to reduce body temperature and inflammation, and the Greek physician Hippocrates used it to help relieve pain and fever. By the early 1800s Europeans were researching the effects of salicylic acid and how to determine a correct dosage of it.2

In 1899, Bayer begin distributing the powder, and it was sold as tablets over the counter in 1915. Doctors gave aspirin to Alexi Nicholaevich Romanov of Russia, who had hemophilia. The aspirin likely made the bleeding worse. When the family’s mystic Grigori Rasputin advised the family to stop modern treatments and rely on spiritual healing, the bleeding improved.

In an article published in 2010 in CNN, one physician from Harvard Medical School recommended reducing the risk of stomach bleeding associated with aspirin by taking a second medication — Prilosec.

By 2012, the U.S. Food and Drug Administration reversed their recommendation, concluding data did not support aspirin as a preventive medication for those who had not had a heart attack, stroke or cardiovascular problems.3 In this population, not only had benefit not been established, but “dangerous bleeding into the brain or stomach” was a significant risk.

Salicylates Found Naturally in Some Foods

In the same year the FDA withdrew their recommendation for daily aspirin intake to reduce cardiovascular risk, one meta-analysis was published showing a reduction and cancer mortality in those taking daily low-dose aspirin.4 The researchers hypothesized the effect was the result of inhibition “of cox-2 in preneoplastic lesions.”

Their results were supported by a second meta-analysis5 published in the same year finding a reduction in nonvascular deaths and cancer with low dose aspirin. In another study published in 2018,6 researchers found data suggesting aspirin is associated with a lower risk of developing several types of cancer, including colorectal, esophageal, pancreatic, ovarian and endometrial.

As New York Times best seller author and nutrition expert Dr. Michael Greger writes,7 animal products made up 5% or less of their diet before Japanese citizens began adopting a Western diet.8 During the same period, there was a vast difference in cancer deaths between the U.S. and Japan.

The age-adjusted death rates for colon, breast, ovary and prostate were five to 10 times lower in Japan, and leukemia, lymphoma and pancreatic cancer death rates were three to four times lower. In part, this protection may have been the result of phytonutrients found in the plant-based diet, including salicylic acid, the active ingredient in aspirin.

The highest concentrations in plants is found in herbs and spices with the greatest amount in cumin. Researchers have found eating a teaspoon of cumin will spike your blood levels of salicylic acid to the same degree that taking a baby aspirin does. Greger9 quotes one study describing the lower incidence of colorectal cancer in areas where people eat diets rich in salicylic acid:10

“The population of rural India, with an incidence of colorectal cancer which is one of the lowest in the world, has a diet that could be extremely rich in salicylic acid. It contains substantial amounts of fruits, vegetables, and cereals flavored with large quantities of herbs and spices.”

In another analysis11 comparing organic versus nonorganic vegetables, scientists found soup made with organic vegetables contained more salicylic acid. Salicylic acid is produced by plants in response to stress, such as when they’re being bitten by bugs. Plants treated with pesticides do not undergo this type of stress, and studies show they contain six times less salicylic acid than those grown organically.

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Is Aspirin Overrated?

Evidence supports the assertion that a plant-rich diet offers protection against certain cancers. Aspirin used to be recommended to reduce clotting time and the risk of heart attack and ischemic stroke, triggered by a clot to the brain. However, long-term use of aspirin has been associated with harmful effects, including hemorrhagic stroke, or bleeding in the brain when a clot doesn’t form.

In addition to aspirin side effects, results from a trio of studies published in the New England Journal of Medicine demonstrated daily low-dose aspirin had no measurably significant health benefits for healthy older adults. Instead, the data demonstrated it did not prolong disability-free survival and contributed to the risk of major bleeding.

In one study the authors found those with helicobacter pylori (H. pylori) infection who used low dose aspirin had a higher risk of upper gastrointestinal bleeding then those who took aspirin without the infection.

In another study12 researchers found those who used aspirin regularly, which they defined as at least once a week for one year, experienced an increased risk of neovascular age-related macular degeneration (AMD). Results from a separate study13 also point to a connection between frequent aspirin use and AMD, linking increasing frequency of use to higher risk.

Nattokinase: Aspirin Alternative Without the Side-Effects

Cardiovascular disease is the leading cause of death14 in people of most racial and ethnic groups in America. The Centers for Disease Control and Prevention reports one person dies every 37 seconds from heart disease and cardiovascular deaths account for 25% of all deaths reported.

Using aspirin to reduce the risk of clot formation comes with significant risk. A better alternative is nattokinase, produced by the bacteria bacillus subtilis when soybeans are being fermented to produce natto. This is a fermented soybean product that has been a traditional food in Japan for thousands of years.

Without using conventional drugs, nattokinase has demonstrated the ability to reduce chronic rhinosinusitis and dissolve excess fibrin in blood vessels, which improves circulation and reduces the risk of serious clotting. Another benefit is the ability to decrease blood viscosity and improve flow, which consequently lowers blood pressure.

Data also showed consuming nattokinase decreased systolic and diastolic blood pressure and demonstrated effectiveness in reducing deep vein thrombosis in those who were on long-haul flights or vehicle travel. Studies have demonstrated administration of a single-dose can enhance clot breakdown and anticoagulation.

Each of these factors affects your long-term cardiovascular health and risk for heart disease. In one study,15 researchers wrote nattokinase is a “unique natural compound that possesses several key cardiovascular beneficial effects for patients with CVD and is therefore an ideal drug candidate for the prevention and treatment of CVD.”

Could Earthworms Hold One Key to Heart Health?

One of the drawbacks of pharmaceutical interventions, including thrombolytics, antiplatelets and anticoagulants, is that they interfere with the anticoagulation system and carry a risk of major bleeding.16 Lumbrokinase is a secondary option that works as a fibrinolytic enzyme, activating the plasminogen system and direct fibrinolysis.

The compound also indirectly achieves anticoagulation through inhibition of platelet function. Additionally, lumbrokinase has an enzyme opposing the coagulation system. Research has demonstrated it promotes fibrinolysis but also fibrinogenesis, meaning it may have a built-in balance system that contributes to the safety record.

Interestingly, this complex enzyme is extracted from earthworms and is sometimes referred to as earthworm powder enzymes. Eastern medicine has used earthworms for thousands of years, and Chinese medicine practitioners believe they possess properties to “invigorate blood, resolve stasis and unblock the body’s meridians and channels.”

They are commonly found in a traditional herbal formula used to treat ischemic or thromboembolic conditions. To date, those producing lumbrokinase cannot make any therapeutic claims. Available studies have demonstrated safety and effectiveness in the treatment of acute ischemic stroke and impressive results in the treatment of coronary arterial disease including those with unstable angina.

Lumbrokinase has also been evaluated as an antimetastatic and antitumor agent, with evidence demonstrating a potential use in anticoagulation to limit cancer growth and metastasis. The authors of two review papers found adverse rates to be 0.7% to 3% with most symptoms being a mild headache, nausea, dizziness and constipation, which resolved when the enzyme was discontinued.

Neither of the reviews found the enzyme triggered bleeding or adverse effects in the kidney or liver. Both nattokinase and lumbrokinase have a lower side effect profile than aspirin and provide much of the same benefits to the cardiovascular system. While aspirin is no longer universally recommended, consider speaking with your physician to include nattokinase or lumbrokinase in your heart health regimen.

Excess Body Fat Can Age Your Brain Faster Than Muscle


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2020/01/09/obesity-and-brain-health.aspx
Analysis by Dr. Joseph Mercola Fact Checked image
January 09, 2020

excess body fat and brain health

STORY AT-A-GLANCE

  • Increasing research shows that maintaining healthy levels of body fat and greater muscle mass has an effect on your brain health and may slow your rate of cognitive aging
  • People with higher amounts of abdominal fat had worse fluid intelligence with age, while those with greater muscle mass were more protected against such declines
  • Women who had greater muscle mass tended to have better scores in fluid intelligence during the study period
  • Past research has linked midlife obesity with an increased risk of mild cognitive impairment, changes in short-term memory and executive functioning and dementia
  • In addition to regular exercise to increase muscle mass, eating a ketogenic diet to maintain a healthy body weight and avoid obesity may support your brain health as you age

Staying fit as you age is about far more than aesthetics. Increasing research shows that maintaining healthy levels of body fat and greater muscle mass has an effect on your brain health and even your rate of cognitive aging. It’s known, for instance, that being obese in midlife and early late-life is associated with worse cognitive aging.1

What’s more, the amount of muscle and fat you have may be a more important factor in how your level of fluid intelligence decreases over time than your chronological age. Your chronological age, i.e., your age in years, is just a numerical measurement, but your real age is your biological age as dictated by your choices and habits, as well as your modifiable risk factors like levels of muscle and fat.

While many people tend to gain fat and lose muscle mass as they age, this can be largely combated by staying active and eating right — lifestyle choices that will influence your cognitive function significantly.

More Muscle, Less Fat Protects Your Brain

In a study by Iowa State researchers, data from 4,431 adults were examined to compare levels of lean muscle mass, abdominal fat and subcutaneous fat with changes in fluid intelligence — the ability to solve problems in new situations — over a six-year period.2,3

Those with higher amounts of abdominal fat had worse fluid intelligence with age, while those with greater muscle mass were more protected against such declines. In fact, women who had greater muscle mass tended to have better scores in fluid intelligence during the study period.

Study co-author Auriel Willette, assistant professor of food science and human nutrition at Iowa State University, said in a news release, “Chronological age doesn’t seem to be a factor in fluid intelligence decreasing over time. It appears to be biological age, which here is the amount of fat and muscle.”4

What’s more, the study revealed a link between the immune system and how changes in fat levels affect cognition. Previous research suggests a higher body mass index (BMI) leads to greater immune system activity in the blood, which in turn activates the immune system in the brain, with a negative outcome on cognitive function.5

The featured study also found that changes in white blood cells called lymphocytes and eosinophils explained the link between abdominal fat and worsening fluid intelligence in women. In men, basophils, another type of white blood cell, were linked to about half of the link between fat levels and fluid intelligence, the study found.6

“Lymphocytes, eosinophils, and basophils may link adiposity to cognitive outcomes,” the researchers explained.7 Similar research has revealed that overweight and obese individual have greater brain atrophy in middle-age, corresponding with an increase in brain age of 10 years.8

How Obesity Affects Your Brain

Obesity has multiple effects on the brain, including anatomically speaking. Obese individuals may have reduced gray matter in brain regions such as the hippocampus, prefrontal cortex and other subcortical regions. Atrophy in the hippocampus, in turn, has been linked to Alzheimer’s disease.9

Gray matter is the outer layer of the brain associated with high-level brain functions such as problem-solving, language, memory, personality, planning and judgment. Even in elderly people who are otherwise cognitively normal, obesity is associated with measureable deficits in brain volume in the frontal lobes, anterior cingulate gyrus, hippocampus, and thalamus compared to individuals with a normal weight.10

Further research published in Radiology found that obesity may lead to alterations in brain structure, shrinking certain regions.11 Among men, higher total body fat percentage was linked to lower brain gray matter volume. Specifically, 5.5% greater total body fat percentage was associated with 3,162 mm3 lower gray matter volume.

Among men, 5.5% greater total body fat was also associated with 27 mm3 smaller globus pallidus volume, an association also seen in women. In women, 6.6% greater total body fat percentage was associated with 11.2 mm3 smaller globus pallidus volume.

The globus pallidus is a brain region that plays a role in supporting a range of functions, including motivation, cognition and action.12 Obesity was also associated with changes in white matter microstructure, which may be related to cognitive function.13

Cognitively speaking, there’s also a strong link between obesity and deterioration in cognitive function, as well as to other brain disorders such as dementia, anxiety and depression. Further, past research has linked midlife obesity with an increased risk of mild cognitive impairment, changes in short-term memory and executive functioning and dementia.14

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Obesity-Associated Health Problems Also Harm Your Brain

Obesity’s effects on brain health are also due to its associated health problems, including heart disease, diabetes and atherosclerosis, each of which can have its own deleterious effects on your brain. For instance, as noted in Frontiers in Neuroscience:15

“Obesity-derived vascular problems, such as atherosclerosis and arteriosclerosis, which are systemic diseases, are known to affect the steady blood flow of vessels that feed the brain, thus contributing to cognitive impairment or even stroke, where large areas of the brain die due to the stop in the blood flow of a major brain artery caused by a blood clot.”

In terms of diabetes, of which obesity is a key risk factor, having this condition in midlife is associated with a 19% greater cognitive decline over 20 years compared with not having the condition.16 Even those with prediabetes had significantly greater cognitive decline than those without.

Indeed, “Epidemiological studies have linked type-2 diabetes mellitus with cognitive impairment and dementia, with insulin resistance and hyperglycemia as the probable mechanistic links,” researchers noted.17

Coming full circle, eating a highly processed, junk food diet not only increases obesity risk but also can lead to normal but elevated blood sugar levels that, in turn, can lead to impaired glucose metabolism and Type 2 diabetes. Both diabetes and higher fasting glucose levels are linked with lower total brain volume.18

Impaired glucose metabolism is then associated with neurodegeneration that impairs cognitive function. This connection begins not in old age but much earlier, such that following a healthy lifestyle in young adulthood may be protective against cognitive decline later.19

The Inflammation Connection

Obesity can trigger chronic inflammation in your body, and chronic inflammation in your brain (neuroinflammation) is known to impair neurogenesis, your brain’s ability to adapt and grow new brain cells. It’s also linked to neurodegenerative disorders such as Alzheimer’s disease (AD), and it’s been suggested that “Obesity may serve as an amplifier or initiator of the chronic inflammation observed in AD patients.”20

Further, higher levels of inflammatory markers have also been associated with lower brain volume, including “greater atrophy than expected for age.”21 Excess body fat, particularly visceral fat, is also related to the release of proteins and hormones that can cause inflammation, which in turn can damage arteries and enter your liver, affecting how your body breaks down sugars and fats.

According to a study in the Annals of Neurology, “[A]dipose-tissue derived hormones, such as adiponectin, leptin, resistin or ghrelin, could also play a role in the relation between adipose tissue and brain atrophy.”22 Further, obesity may also be associated with lower volume in brain regions that regulate food-reward circuitry,23 possibly influencing overeating.

Strength Training Is Good for Your Brain

While obesity takes a toll on your brain, increased muscle mass protects it, which is likely one reason why strength training has been found to be beneficial for your brain. In other words, your body’s physical strength may serve as a marker of your brain power.

In fact, strength training is known to trigger beneficial neurobiological processes,24 leading to positive functional brain changes, including in the frontal lobe, with corresponding improvements in executive functions. One systematic review even found that strength training led to less white matter atrophy in the brain, with researchers noting:25

“Taken together, during aging processes, a substantial decline in muscular strength, especially in lower limb muscles, occurs, and accumulating evidence suggests that lower muscular strengths are linked to poorer cognitive performance.

Hence, resistance (strength) exercises (a single bout of resistance exercise, also referred to as acute exercise) and resistance (strength) training (more than one resistance exercise session, also referred to as chronic exercise … ) seem to be promising activities to ensure the preservation of physical functioning and cognitive functions with aging.”

Regular strength training, in addition to other forms of exercise and daily activity, is an important strategy for keeping your brain sharp and may help to offset some of the cognitive decline that occurs with age.

Avoid Obesity and Protect Your Brain With a Ketogenic Diet

While obesity may accelerate neurodegeneration, regular exercise to increase your muscle mass will be protective. Further, eating a ketogenic diet will help protect your brain from free radical damage and will supply the cells with preferred fuel while also helping you to lose weight and avoid obesity.

A ketogenic diet is high in healthy fats and low in net carbohydrates (total carbs minus fiber), prompting your body to start burning fat as its primary fuel, rather than sugar. This produces ketones, which not only burn efficiently but are also a superior fuel for your brain. Ketones also generate fewer reactive oxygen species (ROS) and less free-radical damage.

One of the simple strategies you can implement is to take ketone precursors like refined MCT oils of caprylic acid (C-8). The eight-chain carbon fats are readily converted to ketones. I personally use up to 5 ounces of our Ketone Energy when I have maxed out my protein and carb intake and need a source of healthy clean fat. This keeps my ketone level around 1 to 2.0 mmol/l. Just recognize that you have to build up to a high dose of MCT oil slowly or you will have problems with loose stools.

Recent studies have also demonstrated the benefits of nutritional ketosis for brain health. In one, researchers found a ketogenic diet improved neurovascular function, in part by improving your gut microbiome.26

In a second study, the researchers concluded a ketogenic diet acted as a veritable “fountain of youth” in their animal study by significantly improving neurovascular and metabolic functions, compared to the animals eating an unrestricted diet.27 Releasing ketones into your bloodstream helps preserve brain function and protects against cognitive impairment and other neurodegenerative diseases.28

KetoFasting, the program I developed and detail in my book, “KetoFast: A Step-By-Step Guide to Timing Your Ketogenic Meals,” combines a cyclical ketogenic diet and intermittent fasting with cyclical partial fasting to optimize health and longevity.

Not only can KetoFasting help you to lose weight, but your cognition typically improves thanks to the biological cleansing and regeneration that occurs throughout your body, including your brain.

Sources and References

TMG Benefits

TMG (Trimethylglycine) is a powerful nutrient, much like a vitamin, functioning as methyl donor, anti-oxidant, anti-inflammatory, energy booster, toxin remover, immune booster and more.
Also called betaine (first isolated from sugar beets) but different from Betaine Hydrochloride.

TMG the Methyl Donor

The TMG molecule comprises three methyl groups (CH3) joined to one molecule of glycine (C2H5NO2). The benefit of TMG is that it releases easily one, two, or all three of the methyl groups.
Releasing one methyl group then leaves behind DMG (Dimethylglycine) which is just TMG with only two methyl groups. Releasing all methyl groups leaves just Glycine, which is the smallest molecule of all of the amino acids, which allows it to go almost anywhere in the body, including crossing the blood-brain barrier.
DMG is considered a B-complex vitamin, shown to help:

  • Behaviour and speech in autistic children and adults
  • ADHD (Attention Deficit-Hyperactivity Disorder)
  • Neurological function
  • Reducing seizures
  • Stress tolerance
  • Oxygen utilisation
  • Liver activity
  • Athletic performance
  • Anti-aging
  • Anti-inflammatory
  • Anti-viral and anti-bacterial
  • Immune boosting
  • Shrinking tumours
  • Allergies
  • Chronic fatigue syndrome
  • Respiratory disorders
  • Alcoholism, drug addiction.
  • Cholesterol and triglycerides
  • Blood pressure
  • Blood glucose

Although DMG has all of these benefits, and is available as a supplement, LeanMachine recommends that people supplement with TMG as we then receive all of the benefits of DMG plus the benefit of 50% better methylation.

Methyl groups (CH3) are essential for millions of biochemical reactions every second in the body, these are a few examples:

  • Lowering homocysteine, an amino acid, which inflames arteries when levels rise, leading to “hardening of the arteries”. Homocysteine levels are a much better indicator of cardiovascular disease than cholesterol. High homocysteine is commonly caused by insufficient methyl groups. The body gets methyl groups from TMGActive FolateActive Vitamin B-12, SAM-eDMAEMethionineTaurine, Cysteine and Vitamin B-6.
    Other causes are mercury and copper toxicity. High homocysteine also causes methionine deficiency, in turn causing SAM-e (S-Adenosyl Methionine) deficiency which can lead to depression. Methionine is required for protein synthesis
  • Excess homocysteine also leads to osteoporosis, birth defects, cancer, ageing and free radicals, all helped by TMG
  • Methyl groups are required for the Phase 2, P450 liver detoxification pathway, a critical biochemical sequence of events. Fat-soluble toxins are joined to a methyl group, enabling a greater water solubility, then allowing the liver to remove them from the body. For toxins unable to be removed, methylation helps render them less toxic
  • TMG increases production of SAM-e, helping to reduce depression
  • TMG reduces risk of diabetes, as insulin release and insulin activity rely on methyl group donation
  • TMG donates methyl groups for protein synthesis (biosynthesis), the copying of genetic code from DNA to RNA (genetic transcription), then to the synthesis (formation) of every chemical in the body
  • TMG insufficiency causes biosynthesis slowing, telomeres shortening, and genetic errors (transcription errors) raises cancer risk from DNA mutations

The Methylation Process

This is a vital and most common chemical process in hundreds of essential chemical reactions, including:

  • Methylation is essential for manufacture of all the chemicals for the body
  • Stops certain viruses that could damage DNA
  • Stops the production of trophoblast (fast-growing cells that may lead to cancer)
  • Suppresses replication of DNA in areas where the body does not want it replicated
  • Important for neurological chemicals and blood chemicals
  • Corrects timing problems of the X chromosome in cell replication
  • Causea a genetic trait to come from only one parent, and not both
  • Prevents some genetic diseases
  • Helps prevent shortening of gene telomeres
  • Methylation is a primary method of removing toxins in the phase 2 liver detoxification system
  • Methylation converts toxins of all kinds from insoluble, less soluble or fat-soluble compounds into water-soluble compounds to allow excretion. Larger molecules are eliminated through the bile, smaller ones are excreted in the urine
  • Methylation is required for synthesis of dopamine and serotonin, improving mood, energy, wellbeing, alertness, concentration, and visual clarity
  • Methylation helps with liver detoxification
  • Methylation is required for conversion of homocysteine to methionine, which converts to other amino acids by various pathways
  • Methylation helps balance hormones such as estrogens, reducing risk of estrogen-related cancers
  • Reduces inflammation by removing toxins, balancing hormones, synthesising neurotransmitters and other methods
  • Methylation protects the mitochondria and adaptive energy production to stop us from becoming very tired
  • Restores SAM-e in spinal fluid, working as a methyl donor when restored by methyl groups
  • Methylation is required for the body to make CoQ10 (Coenzyme Q10), vital for heart health and energy production in the mitochondria
  • Methylation increases muscle mass, important in cancer and other wasting diseases, and for general health
  • Methylation may improve libido in some people

Who needs TMG?

Almost everyone needs supplemental TMG, even healthy people with a healthy diet, to provide enough methylation for modern life. Those subject to stress, toxins, cardiovascular disease, mental illness, depression, fatigue, exhaustion or almost any other medical condition, almost certainly need extra TMG.

Other benefits of TMG

The Parasympathetic System

TMG can improve the parasympathetic system, helping balance the autonomic nervous system. Hair mineral analyses show about half the population has an autonomic nervous system imbalance (sympathetic dominance), where the sympathetic (fight-or-flight) nervous system is “switched on” too often and too long, usually due to stress, causing many chronic health conditions. TMG may help reverse any imbalance, contributing to healing. Some doctors use “sympathetic dominance” in a different context such as “a sympathetic state of body chemistry” which is different from “sympathetic dominance” used here.

The MTHFR Defect

Almost half the people on Earth have the abnormal MTHFR gene expression, where the biosynthesis of folate is reduced, sometimes marginally, sometimes largely.
Often incorrectly called a “genetic defect” when it is actually a transcription error, polymorphism or abnormal gene expression where errors occur in copying the DNA code rather than a problem with the actual DNA code.
This is why Active Folate has benefits, as it is already in the (6S)-5-methyltetrahydrofolate form required by the body, while regular folate must be converted in the body to this form.
TMG can help supply the methyl groups where insufficent folate cannot. Active folate can be up to 700% more useful in the body, compared to regular folic acid. Note that folic acid is a cheap folate substitute used in many foods claiming to be “folate enriched” but folic acid may prevent absorption of real folate in foods or active folate supplements, and LeanMachine advises total avoidance of foods or supplements containing folic acid.

Antioxidant and anti-inflammatory

There are not many reports on these properties, but they do exist, possibly as a result of methyl group donation

Effects on the Brain

TMG has a positive effect on the brain, likely due to methylation and SAM-e production. Recommended for those at high risk for Alzheimer’s, dementia, Parkinsons, depression, anxiety, seizures, migraine headache, ADHD (Attention Deficit-Hyperactivity Disorder), MS (Multiple Sclerosis) and other brain conditions.

SAM-e Benefits

1. Heart Disease

SAM-e is used for heart disease, also for fibromyalgia, abdominal pain, osteoarthritis, bursitis, tendonitis, chronic lower back pain, ageing, CFS (Chronic Fatigue Syndrome), improving mental performance, liver disease, spinal cord injury, lead poisoning, to break down bilirubin or porphyrin (or precursors).

2. PMS

SAM-e is often taken for PMS (Premenstrual Syndrome) and a more severe form PMDD (Premenstrual Dysphoric Disorder).

IV use of SAM-e

IV (Intravenous) use of SAM-e is used for depression, osteoarthritis, AIDS-related nervous system disorders, fibromyalgia, liver disease, cirrhosis, and intrahepatic cholestasis (a liver disorder in pregnant women)

SAM-e Injections

SAM-e is often injected for fibromyalgia, depression, and Alzheimer’s disease.

Effects on Digestion

TMG aids digestion, again likely because of positive methylation throughout the body.

Glycine

Glycine is the component left over when all three methyl groups have been donated from TMG.
Glycine is the smallest of the amino acids and very important for collagen formation and many other functions. Collagen, the most abundant protein in the body, is used for connective tissue: Tendons, ligaments, cartilage, skin, nails, arteries, veins, etc. Without collagen, we could not stand up, our body would be a pile of mush on the floor!
Glycine, in large doses (up to 3000 mg daily), has been found helpful for sleep and alertness. Although not recommended as a first-line supplement for sleep, it may help if other supplements like Valerian fail to work. This may explain why TMG helps induce restful sleep in some individuals.

Natural sources of TMG

TMG is normally made in the body, but not enough when there are toxins present or the diet is poor or absorption of nutrients is a problem.
TMG can come from the diet. Foods high in TMG include broccoli, quinoa, spinach, lamb, chicken, and beets. A vegetarian or vegan diet tends to be very low in TMG. Foods high in TMG are usually also high in folate, and both are methyl donors.
However, most people do not eat enough of these foods, and even eating large amounts will not provide enough TMG for optimum health.

Risk factors for low TMG

Generally, the body cannot make enough, the modern diet is poor in TMG, and the number of pesticides, chemicals, heavy metal contamination uses up all TMG available.

  • Mercury is a poison that lowers TMG production in the body, and at the same time increases the need for TMG in the body. Almost everyone is mercury toxic now, as mercury is everywhere in the environment, especially in seafood and in dental amalgam fillings
  • Copper toxicity also interferes with TMG, and most people today are toxic from copper pipes, tapware, cookware even if blood or urine tests are negative. While copper is essential for the body to build hemoglobin in blood, we need Chelated Copper from food or supplements, not metallic copper from copper pipes and cookware. Zinc deficiencies cause accumulation of copper in the body, and women have a higher risk than men. Causes headaches, female organ problems, depression, anxiety, skin conditions. Too much zinc (and/or magnesium) competes with copper for absorption, often leading to a copper deficiency.

Supplements

Supplementary TMG is helpful for most people because of low body production, low in the diet, and higher requirements in our toxic world.
TMG 1000mg 100 tablets (most popular, best value).

Stress

Stress, inflammation, inflammation and some diseases increase our need for more TMG.

Dosage of TMG

  • Women: Up to 1000 mg daily
  • Men: Up to 3000 mg daily
  • Children: Less than adults, in proportion to body weight

There are no reliable guides or tests to determine TMG dosage, but the figures above should be a good starting point.
If the sodium/potassium ratio is low, extra TMG may help.
Do not overdose, as too much TMG may lead to over-methylation, causing fatigue, nausea, hair loss, dizziness or other symptoms.
Most people have no side effects from TMG apart from feeling better, getting better sleep and having more energy.
Cautions:
Do not continue a high dose for extended periods.
Children need proportionately less TMG than adults, depending on their size and weight, but babies generally do not need TMG. Older children may need about 250 to 500 mg daily.
TMG is available as tablets, liquid capsules or crystals. Some children and the elderly may have problems with swallowing tablets. TMG has a sweet taste, so TMG crystals can be simply added to food.
Some people have problems tolerating TMG, so they may need a smaller dose. Try reducing the dose until any symptoms disappear.
People who have unresolved resentments seem to have more problems taking TMG, as an enzyme is activated which can cause anger, fear, depression or anxiety symptoms. These symptoms disappear if the dose is reduced or eliminated, but if one can tolerate the symptoms, TMG may help the person resolve their issues of conflict.
Some reports suggest that too much TMG may cause diarrhea and nausea, and may raise cholesterol levels, so those with high cholesterol should keep the level monitored.

Poor Methylation

Several factors affect poor methylation, such as:

  • Raw vegetables are considered healthy, but cooked vegetables provide more dietary methyl groups
  • Sugars in any form appear to harm correct methylation, and are bad for our health anyway
  • Fermented foods are healthy, but are problem for methylation because:
    • Some contain aldehydes (toxic to the liver), including kombucha tea, kimchi, and most fermented grains
    • They contain ferments, which are bacteria or yeasts

    Safer fermented foods, eaten in moderation, include yogurt, kefir, miso and most good quality cheeses

  • Too much animal protein in the diet can cause high methionine and reduce methylation
  • Fighting inflammation or infections consumes methyl groups, requiring more methylation
  • Heavy metal toxicity, especially copper and mercury, interfere with methyl group formation
  • High-dose niacin or niacinamide cause the body to use up methyl groups to detoxify and excrete niacin through the liver. Doses less than 50 mg daily are generally tolerated well
  • Any liver toxins will reduce formation of methyl donors, also liver detoxification pathways require methyl groups, using up more methyl groups
  • Methyl donor production seems to decrease with age, so seniors need more TMG
  • Women of child-bearing age have much better methylation than men. Men always need more TMG than women

Methylation and Cancer

Cancer increases the need for methylating agents like TMG. People often die with cancer because they cannot eliminate their toxic metals and chemicals because of poor liver methylation, so toxins accumulate until death occurs.

Hair Mineral Analysis

More TMG may be required if a hair mineral test reveals:

  • High zinc level, which may indicate presence of hidden toxic metals
  • “Four lows pattern” meaning all four electrolyte minerals low: Calcium, Magnesium, Sodium, Potassium. Indicates impaired methylation
  • High mercury, becoming more common
  • High copper
  • High levels of the other toxic metals

These results indicate long-term toxic metal exposure.

LeanMachine online supplemments

Disclaimer

LeanMachine is not a doctor, and everyone should consult with their own health professional before taking any product to ensure there is no conflict with existing prescription medication.
LeanMachine has been researching nutrition and health since 2010 and has completed many relevant studies including:
Open2Study, Australia – Food, Nutrition and Your Health
RMIT University, Australia – Foundations of Psychology
Swinburne University of Technology, Australia – Chemistry – Building Blocks of the World
University of Washington, USA – Energy, Diet and Weight
Johns Hopkins Bloomberg School of Public Health, USA – Health Issues for Aging Populations
Johns Hopkins Bloomberg School of Public Health, USA – International Nutrition
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics I
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics II
Johns Hopkins Bloomberg School of Public Health, USA – Principles of Human Nutrition
TUFTS University, USA – Nutrition and Medicine
TUFTS University, USA – Lipids/Cardiovascular Disease I and Lipids/Cardiovascular Disease II
Technical Learning College, USA – Western Herbology, Identification, Formulas
Bath University, England – Inside Cancer
WebMD Education – The Link Between Stroke and Atrial Fibrillation
WebMD Education – High Potassium: Causes and Reasons to Treat
Leiden University Medical Center, Netherlands – Anatomy of the Abdomen and Pelvis
MIT (Massachusetts Institute of Technology) – A Clinical Approach to the Human Brain
LeanMachine has now examined thousands of studies, journals and reports related to health and nutrition and this research is ongoing.

Updated 9th January 2020, Copyright © 1999-2020 Brenton Wight and BJ & HJ Wight trading as Lean Machine abn 55293601287

Warfarin – The Rat Poison Drug

Written by Brenton Wight – LeanMachine, Health Researcher
Posted 8th December 2017, Updated 4th December 2019.
Copyright © 1999-2019 Brenton Wight and BJ&HJ Wight trading as Lean Machine abn 55293601285

Why use Warfarin?

Warfarin is a blood thinner, belonging to a class of drugs known as anti-coagulants, designed to keep blood thin and prevent clots. They make it hard for clots to form, which is a good thing if we are trying to prevent an ischemic (blood blockage) stroke, but a bad thing if we have a hemorrhagic (bleeding)stroke.
It is the most often prescribed drug prescribed for AF (atrial fibrillation), a type of irregular heartbeat, where upper chambers of the heart quiver instead of contracting efficiently, affecting millions of people.
Although AF is not necessarily life-threatening by itself, it can increase risk of blood clots which can break free to cause an ischemic stroke if the clot lodges in a brain artery, or pulmonary thrombosis if lodged in a lung artery.
However, there are down sides.
– Warfarin makes it difficult to stop a cut from bleeding.
– Warfarin increases risk of a hemmorhagic stroke (bleeding in the brain).
– Warfarin increases risk of intestinal bleeding.
– Warfarin increases risk of an aneurysm where a blood vessel ruptures.
– Warfarin increases risk of uncontrolled bleeding due to a fall or accident.

The Warfarin Study

A new study shows that Warfarin (marketed under the name Coudamin), a heart drug taken by millions of people, increases dementia risk 300%.
This study, led by Dr. T. Jared Bunch, was conducted by the Intermountain Healthcare Clinical Pharmacist Anticoagulation Service, based in Salt Lake City, and examined the medical records of more than 10,000 patients.
Dr Bunch presented the study results at the Heart Rhythm Society’s annual meeting in San Francisco.
The findings were:

  • Patients with erratic warfarin levels have a higher risk of small clots, or small bleeds in the brain, causing dementia
  • AF patients have three times the risk of dementia compared to those who take warfarin for other conditions
  • Some foods, drinks, antibiotics and other drugs alter warfarin blood levels quickly. Regular blood tests and dose variations are essential to maintain the correct range
  • The dementia risk increases to four times higher if the dose is not exactly right or requires frequent adjustment

History of Rat Poison

The University of Wisconsin developed the drug as a rat poison in the 1940’s. It kills rodents by invoking bleeding. Rats bleed to death after ingesting the poison.
Endo Laboratories began selling it for human use in the 1950’s, but Warfarin proved to be a management problem for doctors and patients. Bad reactions to many foods and some drugs, especially antibiotics, are common with Warfarin treatment.

Warfarin Side Effects

Another study by New England Journal of Medicine showed that warfarin accounts for double the emergency hospitalizations than any other drug, and is the leading cause of emergency room visits by seniors.
Apart from dementia, warfarin causes internal bleeding, stomach ulcers, kidney failure, and chronic cough. Hillary Clinton takes warfarin, and has suffered a severe cough while campaigning in 2016.
Of course, given that dementia is a common problem with seniors, and the risk for dementia is three to four times higher, more dementia means more missed or doubled-up doses of Warfarin, sometimes leading to death of the patient.

Prescription Alternatives

There are a few options:

  • Apixaban (Eliquis)
  • Dabigatran (Pradaxa)
  • Edoxaban (Savaysa)
  • Rivaroxaban (Xarelto)

Whichever we use, there is always a risk of bleeding problems.
The new medications have a reduced risk of bleeding, and wear off faster than warfarin, so appear to be safer.
However, dangerous bleeding while taking warfarin can be controlled with Vitamin K, or a combination of PCC (prothrombin complex concentrate) and fresh frozen plasma.
The amount of vitamin K in the diet, contained in leafy green vegetables, determines the effectiveness of Warfarin, so we must consistently eat the same foods. We can eat salads (and we should) but we have to eat them all the time with warfarin. This is not a problem for the new drugs because Vitamin K does not interfere with their operation. If we ate plenty of salads regularly throughout our life, we would probably never need warfarin!
Praxbind (idarucizumab) can be used in emergencies to reverse the anti-clotting effects of Pradaxa.
Other drugs to reverse blood-thinning are still in development.
Xarelto currently (in 2019) has no approved antidote, meaning that an overdose or a bleed from, say, a fall resulting in a nasty bump on the head, could cause death by a brain bleed.
Because Xarelto and others have no really effective antidote, bleeding is difficult to control. Given that many seniors with poor cognitive function are taking these drugs, overdosing is common, and can cause death. A horrifying sight in the emergency room is a patient bleeding from the nose, eyes, fingernails, toenails etc.

Drugs and Lifestyle

The new drugs are more convenient in that they do not require as many blood tests as warfarin, which requires testing at least monthly, after getting the initial dose right, where the starting dose is high, followed by a maintenance dose, and blood tests are required every 2 to 3 days until the levels stabilise.
Apart from the inconvenience of regular blood testing, many people do not like getting stuck with a needle so often.

Interaction with Other Medications

Some prescription drugs, some supplements and some foods interfere with warfarin, while others make warfarin work too well, which can cause a major bleeding problem.
Some seniors have presented at the emergency room with blood coming from all fingernails, toenails, eyes, nose, mouth, etc.
Often the slightest bump in the body results in extensive bruising, and a small cut results in excessive bleeding.
There is an enormous list of medications that interact with warfarin. The newer blood thinners also have interactions, but nowhere near as many.
The new blood thinners have some benefits over warfarin, but if we manage our warfarin well, there is no need to change. However, if we have kidney failure or mechanical heart valves the new medications may not be safe.

Natural Alternatives

Warfarin patients whose dosages often change should ask their doctor for alternative medications, as other blood thinners have fewer potential problems.
Aspirin is another blood-thinning medication given to those with cardiovascular problems, but again, can cause massive problems with internal bleeding, loss of eyesight from Macular Degeneration (bleeding and expansion of blood vessels in the retina), or hemmorhagic stroke (brain bleed).
Natural remedies work well for some people, and here are a few known to work:

These or other natural alternatives may require Warfarin levels to be lowered. Thinning the blood too much while taking Warfarin may be very dangerous.
Green leafy vegetables, high in vitamin K, act as an antidote to warfarin, requiring higher dosage for effectiveness, but a change in diet will cause a higher risk of bleeding.

LeanMachine online supplements

Disclaimer

LeanMachine is not a doctor, and everyone should consult with their own health professional before taking any product to ensure there is no conflict with existing prescription medication.
LeanMachine has been researching nutrition and health since 2011 and has completed many relevant studies including:
Open2Study, Australia – Food, Nutrition and Your Health
RMIT University, Australia – Foundations of Psychology
Swinburne University of Technology, Australia – Chemistry – Building Blocks of the World
University of Washington, USA – Energy, Diet and Weight
Johns Hopkins Bloomberg School of Public Health, USA – Health Issues for Aging Populations
Johns Hopkins Bloomberg School of Public Health, USA – International Nutrition
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics I
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics II
Johns Hopkins Bloomberg School of Public Health, USA – Principles of Human Nutrition
TUFTS University, USA – Nutrition and Medicine
TUFTS University, USA – Lipids/Cardiovascular Disease I and Lipids/Cardiovascular Disease II
Technical Learning College, USA – Western Herbology, Identification, Formulas
Bath University, England – Inside Cancer
WebMD Education – The Link Between Stroke and Atrial Fibrillation
WebMD Education – High Potassium: Causes and Reasons to Treat
Leiden University Medical Center, Netherlands – Anatomy of the Abdomen and Pelvis
MIT (Massachusetts Institute of Technology) – A Clinical Approach to the Human Brain
LeanMachine has now examined thousands of studies, journals and reports related to health and nutrition and this research is ongoing.

Posted 8th December 2017, Updated 4th December 2019. Copyright © 1999-2019 Brenton Wight and BJ & HJ Wight trading as Lean Machine abn 55293601285

The connection between artificial sweeteners and diabetes

Reproduced from original article:
www.naturalhealth365.com/artificial-sweeteners-diabetes-3201.html

by:  

artificial-sweeteners-news

(NaturalHealth365) According to the American Diabetes Association, diabetes has become a pandemic, affecting 30 million people in the United States alone. Unfortunately, the rate of diabetes continues to grow exponentially due to the overconsumption of processed foods – which dominate the standard American diet or its more popular name, “SAD.”

Shockingly, by 2030, WHO is predicting diabetes will become the seventh leading cause of death around the world.  So, what’s the main ingredient fueling this health crisis of metabolic disorders?  Look no further than the consumption of artificial sweeteners, under names like, Sweet’N Low, NutriSweet, Equal, aspartame – the list goes on and on.

Listen to the experts: Artificial sweeteners are neurotoxic – causing major health problems

A study at the Imperial College of London found that people who drink a single 12-ounce soda a day increased their risk of type-2 diabetes by 18 percent – compared to those who avoided soda.

A study from Harvard Medical School and Brigham and Women’s Hospital in Boston found that women who drink one soda per day double their risk of developing type 2 diabetes – compared to women who drink less than one soda per month.

In addition, if these quotes (below) don’t make you think twice about consuming artificial sweeteners … then, nothing will.

Do NOT ignore the health dangers linked to toxic indoor air.  These chemicals – the ‘off-gassing’ of paints, mattresses, carpets and other home/office building materials – increase your risk of headaches, dementia, heart disease and cancer.

Get the BEST indoor air purification system – at the LOWEST price, exclusively for NaturalHealth365 readers.  I, personally use this system in my home AND office.  Click HERE to order now – before the sale ends.

“Unfortunately, many patients in my practice, and others seen in consultation, developed serious metabolic, neurologic and other complications that could be specifically attributed to using aspartame products. This was evidenced by the loss of diabetic control, the intensification of hypoglycemia, the occurrence of presumed ‘insulin reactions’ (including convulsions) that proved to be aspartame reactions, and the precipitation, aggravation or simulation of diabetic complications (especially impaired vision and neuropathy) while using these products… dramatic improvement of such features after avoiding aspartame, and the prompt predictable recurrence of these problems when the patient resumed aspartame products, knowingly or inadvertently.” – H.J.Roberts, M.D., F.A.C.P., F.C.C.P

“In view of all these indications that the cancer-causing potential of aspartame is a matter that had been established way beyond any reasonable doubt, one can ask: What is the reason for the apparent refusal by the FDA to invoke for this food additive the so-called Delaney Amendment to the Food, Drug and Cosmetic Act? Is it not clear beyond any shadow of a doubt that aspartame has caused brain tumors or brain cancer in animals?” – Dr. Adrian Gross, former FDA toxicologist

“So in the case of diet drinks in aluminum cans, the very toxic brain aluminum fluoride compound co-exists with multiple toxins found in aspartame, thus creating the most powerful government-approved toxic soup imaginable. With the strong association between aluminum, excitotoxins, aluminum fluoride complexes and Alzheimer’s disease, it would be completely irresponsible to encourage people to consume this toxic mixture.” – Russell Blaylock, M.D.

Uninformed consumers, in an effort to reduce sugar intake and reduce the risk of diabetes, tend to think that artificial sweeteners offer some kind of “safe” alternative to processed sugar. But, as we now know, the scientific evidence is abundantly clear – consuming artificial sweeteners actually increase the risk of obesity, diabetes plus many other health problems.

How artificial sweeteners cause glucose intolerance

When researchers from the Weizmann Institute of Science in Rehovot, Israel began studying the effects of aspartame, sucralose and other artificial sweeteners in the body, what they found was startling. Data acquired through the study revealed a significant change within the composition and function of the ‘good’ bacteria within the intestines of mice fed a steady measure of various non-caloric artificial sweeteners.

Since these bacteria play an important role in digestion and glucose metabolism, threatening this balance of good and bad bacteria, within the gut, by eating artificial sweeteners can lead to glucose intolerance, over time.

In addition to changing the intestinal bacterial composition, artificial sweeteners were also linked to higher blood sugar levels. People who regularly consume chemical sugar substitutes were found to have greater difficulty regulating blood sugar, and people who do not normally consume artificial sweeteners experienced higher blood sugar levels after doing so for just one week.

One of the researchers at Weizmann, Eran Elinav, told reporters during a news conference that he made a decision to stop using artificial sweeteners because of the surprising results of the study.

Artificial sweeteners proven to do more harm than good

With scientific data that upholds the dangers of artificial sweeteners within the gut and other areas of the body, why would anyone continue consuming these dangerous substances? Furthermore, why are these substances still touted as ‘safe’ and even beneficial for people who need to lower their sugar intake or calorie consumption?

Sadly, there are many organizations like, the American Cancer Society … that continue to push the notion that aspartame is “safe” and does not cause cancer.  Just look at what they say … and we’ll let you decide how deceptive they are.

In about 6,000 food products, artificial sweeteners lurk in all kinds of commonly consumed products such as, sugar-free gum, diet sodas, breakfast cereals, baby food and even the most popular brands of yogurt. It’s no wonder we see the steady growth of obesity, diabetes and neurological diseases like, Alzheimer’s.

Instead of using these neurotoxin poisons to prevent or “manage” diabetes, we must learn to enjoy natural sugars (in moderation) and commit to a lifestyle of clean, healthy living – including the consumption of organic vegetables, fruits, sprouted nuts, seeds plus a reasonable amount of healthy fats and proteins … as much as possible.

Combined with an active lifestyle, a balanced diet of real food – found in nature – free of artificial sweeteners and other food additives … will enable you to maintain a healthy blood sugar level and never be concerned about diabetes.

Sources for this article include:

Clinical.Diabetesjournals.org
Nature.com

8 Juicy Reasons to Eat More Strawberries

© 30th October 2019 GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here www.greenmedinfo.com/greenmed/newsletter
Reproduced from original article:
www.greenmedinfo.health/blog/8-juicy-reasons-eat-more-strawberries

Posted on: Wednesday, October 30th 2019 at 11:00 am

Who doesn’t love strawberries? And you don’t need any reason other than the pleasure of their sweetness to eat them every day. But according to researchers from Oklahoma State University, there’s lots more to strawberries than the flavor.[i]

Their study was published in the journal Critical Reviews in Food Science and Nutrition with funding from the NIH and the California Strawberry Commission. In it the researchers review over 130 studies attesting to the strawberry’s status as a “functional food.”

There is no regulated meaning for the term “functional food.” But it usually refers to a food that provides some benefit in addition to calories that may reduce disease risk or promote general health. That can be said of every fresh, organic whole food. But functional food is also a term that has become a marketing tool for food manufacturers who “enrich” their processed foods with vitamins, minerals, herbs and other supplements.

But strawberries don’t need any enriching. They consistently rank among the top fruits and vegetables for health benefits. They are full of powerful natural compounds that include:

  • Antioxidants – Strawberries were found to have higher oxygen radical absorbance capacity (ORAC) activity than black raspberries, blackberries or red raspberries.[ii] One study even found strawberries have the highest antioxidant capacity of ALL fruits and vegetables commonly available in the UK as measured by the trolox equivalent antioxidant capacity (TEAC) assay.[iii]
  • Polyphenols – Strawberries have been listed among the 100 richest sources of dietary polyphenols.[iv] They contain flavonoids like catechin, epicatechin, quercetinkaempferol, cyanidins, naringenin, hesperadin, pelargonidin, ellagic acid and ellagitannins. Flavonoids are free radical scavengers, and have anti-inflammatory effects. They also dilate blood vessels and slow tumor growth.
  • Vitamins and Minerals – Strawberries are high in vitamin C (ascorbic acid), B vitamins, vitamin E, folate, carotenoids and potassium.
  • Anthocyanins – These are water-soluble compounds responsible for the deep colors of berries and are among the principal bioactives in strawberries.
  • Phytosterols – These plant-derived sterols have structures and functions similar to cholesterol.

All of those natural components translate to a broad range of health benefits. Animal and cell culture studies show strawberries may be effective in reducing risk factors for cardiovascular disease including obesity, hyperglycemiahyperlipidemiahypertension, and oxidative stress.

Here are eight scientifically proven reasons to eat more strawberries:

1. Strawberries Lower Heart Attack Risk

In an analysis of data from over 93,000 subjects in the famous Nurses’ Health Study I and the Nurses’ Health Study II, researchers looked at the effects of eating strawberries and blueberries on cardiovascular health. They found that over a 14-year period, women eating just three servings weekly of blueberries or strawberries reduced their risk of heart attack by 33% compared to those eating berries once monthly or less.[v]

In addition, in an analysis of data from over 34,489 postmenopausal women in the Iowa Women’s Health Study, eating strawberries was associated with a significant reduction in deaths from cardiovascular disease over a 16-year follow-up period.[vi]

2. Strawberries Reduce Hypertension

Researchers again used the data from the two Nurses Studies as well as data from the Health Professionals Follow-Up Study to measure cardiovascular health benefits of strawberry and blueberry anthocyanins. They found that higher intakes of strawberry and blueberry anthocyanins (16-22 mg/day) were associated with a significant 8% reduction in the risk of hypertension. That was compared to those consuming only 5-7 mg/day of berry anthocyanins.[vii]

3. Strawberries Lower Inflammation and C-Reactive Protein (CRP)

In a study of 38,176 female US health professionals enrolled in the Women’s Health Study participants were asked whether they ate fresh, frozen, or canned strawberries “never,” or “less than one serving per month,” or up to “6+ servings per day.” Over an 11-year follow-up period, cardiovascular disease was lower among those consuming more strawberries.

CRP levels were significantly reduced among women consuming just two or more servings of strawberries per week.[viii]Elevated CRP is strongly associated with inflammation and is a high-risk factor for cardiovascular disease.

4. Strawberries Reduce Cancer Risk

In a prospective five-year cohort study in an elderly population, higher consumption of fresh strawberries and other fruits and vegetables was associated with significantly reduced cancer mortality. The authors attribute these observations to the carotenoid content of fruits and vegetables known to exert anti-carcinogenic effects.[ix]

In another larger five-year prospective cohort study, eating more foods from the Rosaceae botanical subgroup, including strawberries, was associated with a protective effect against esophageal squamous cell carcinoma compared to eating less of this fruit group.[x] The same cohort also reported reduced rates of head and neck cancer among those consuming more servings of the Rosaceae botanical subgroup including strawberries.[xi]

Other studies show that strawberries can even reverse early stage esophageal cancer.

5. Strawberries Reduce Oxidized Cholesterol

Studies show strawberries increase plasma antioxidant capacity helping to reduce oxidized LDL cholesterol. In human trials fresh, frozen, or freeze-dried strawberries were shown to reduce oxidative stress associated with metabolic syndrome or eating high-fat meals.[xii]

6. Strawberries Lower LDL Cholesterol and Raise HDL Cholesterol

The fiber, phytosterols, and polyphenols in strawberries have been shown to lower serum total and LDL cholesterol.[xiii] It’s also been shown to raise serum high-density lipoprotein (HDL)-cholesterol.[xiv]

7. Strawberries Help Control Blood Glucose Levels

Polypenols in a berry mixture that included strawberries produced a lower glucose response after eating a meal.[xv]

8. Strawberries May Help Reverse Age-Related Neurodegenerative Disorders

In an animal study researchers at the USDA Human Nutrition Research Center on Aging at Tufts found that strawberry extracts significantly reversed signs of age-related neuronal deficits.[xvi]

And animals eating a diet including 2% strawberries for two months showed significant protection from radiation damage to neurons.[xvii] Researchers suggest that strawberries and other berries may have a role in reversing Alzheimer’s disease or Parkinson’s disease.[xviii]

Are Fresh or Frozen Strawberries Better?

Studies show benefits to all forms of strawberries whether fresh, frozen, dried, pureed, or made into juices or jams. But the more they’re processed the more strawberries can lose some of their active compounds.

Frozen strawberries have significantly higher vitamin C (ascorbic acid) and polyphenols than freeze-dried or air-dried.[xix] Processing strawberries into juices and purees also results in a loss of ascorbic acid, polyphenols, and antioxidant capacity.[xx] And canning strawberries or making them into jams can significantly reduce the levels of anthocyanins and total phenolic compounds.[xxi]

Fresh or frozen are the best choices for health benefits when it comes to strawberries. But processed strawberry products still have some benefits and are a good choice when the real things aren’t in season.

Just remember to buy organic berries. Most conventionally grown strawberries are heavily sprayed with pesticides.

For more studies visit GreenMedInfo’s page on strawberries.

Originally published: 2014-10-07

Article updated: 2019-10-30


References

[i] Arpita Basu , Angel Nguyen , Nancy M. Betts & Timothy J. Lyons “Strawberry As a Functional Food: An Evidence-Based Review.” Critical Reviews in Food Science and Nutrition, (2014) 54:6, 790-806.

[ii] Wang, S. Y., and Lin, H. S. (2000). “Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage.” J. Agric. Food Chem. 48:140-146.

[iii] Proteggente, A. R., Pannala, A. S., Paganga, G., Van Buren, L., Wagner, E., Wiseman, S., Van De Put, F., Dacombe, C., and Rice-Evans, C. A. (2002). The antioxidant activity of regularly consumed fruit and vegetables reflects their phenolic and vitamin c compositionFree Radic. Res. 36:217-233.

[iv] P’erez-Jim’enez, J., Neveu, V., Vos, F., and Scalbert, A. (2010). “Identification of the 100 richest dietary sources of polyphenols: An application of the phenolexplorer database.” Eur. J. Clin. Nutr. 64:S112-S120.

[v] Aedín Cassidy, Kenneth J Mukamal, Lydia Liu, Mary Franz, A Heather Eliassen, Eric B Rimm. High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women. Circulation. 2013 Jan 15 ;127(2):188-96.

[vi] Mink, P. J., Scrafford, C. G., Barraj, L. M.,Harnack, L., Hong, C. P.,Nettleton, J. A., and Jacobs, D. R., Jr. (2007). Flavonoid intake and cardiovascular disease mortality: A prospective study in postmenopausal womenAm. J. Clin. Nutr. 85:895-909.

[vii] Cassidy, A., O’Reilly, E. J., Kay, C., Sampson, L., Franz, M., Forman, J. P., Curhan, G., and Rimm, E. B. (2010). Habitual intake of flavonoid subclasses and incident hypertension in adults. Am. J. Clin. Nutr. 93:338-347.

[viii] Sesso, H. D., Gaziano, J. M., Jenkins, D. J., and Buring, J. E. (2007). Strawberry intake, lipids, c-reactive protein, and the risk of cardiovascular disease in womenJ. Am. Coll. Nutr. 26:303-310.

[ix] Colditz, G. A., Branch, L. G., Lipnick, R. J.,Willett,W. C., Rosner, B., Posner, B. M., and Hennekens, C. H. (1985). Increased green and yellow vegetable intake and lowered cancer deaths in an elderly populationAm. J. Clin. Nutr. 41:32-36.

[x] Freedman, N. D., Park, Y., Subar, A. F., Hollenbeck, A. R., Leitzmann, M. F., Schatzkin, A., and Abnet, C. C. (2007). Fruit and vegetable intake and esophageal cancer in a large prospective cohort studyInt. J. Cancer. 121:2753-2760.

[xi] Freedman, N. D., Park, Y., Subar, A. F., Hollenbeck, A. R., Leitzmann, M. F., Schatzkin, A., and Abnet, C. C. (2008). Fruit and vegetable intake and head and neck cancer risk in a large United States prospective cohort studyInt. J.Cancer. 122:2330-2336.

[xii] Paiva, S. A., Yeum, K. J., Cao, G., Prior, R. L., and Russell, R. M. (1998). Postprandial plasma carotenoid responses following consumption of strawberries, red wine, vitamin c or spinach by elderly womenJ. Nutr. 128:2391-2394.

[xiii] Basu, A., Fu, D. X., Wilkinson, M., Simmons, B., Wu, M., Betts, N. M., Du, M., and Lyons, T. J. (2010). Strawberries decrease atherosclerotic markers in subjects with metabolic syndromeNutr. Res. 30:462-469.

[xiv] Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P.,Mattila, P., and Jula, A. (2008). Favorable effects of berry consumption on platelet function, blood pressure, and hdl cholesterolAm. J. Clin. Nutr. 87:323-331.

[xv] T¨orr¨onen, R., Sarkkinen, E., Tapola, N., Hautaniemi, E.,Kilpi, K., andNiskanen, L. (2010). Berries modify the postprandial plasma glucose response to sucrose in healthy subjectsBr. J. Nutr. 103:1094-1097

[xvi] Joseph, J. A., Shukitt-Hale, B., Denisova, N. A., Prior, R. L., Cao, G., Martin, A., Taglialatela, G., and Bickford, P. C. (1998). Long-term dietary strawberry, spinach, or vitamin e supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficitsJ. Neurosci. 18:8047-8055.

[xvii] Rabin, B. M., Joseph, J. A., and Shukitt-Hale, B. (2005). Effects of age and diet on the heavy particle-induced disruption of operant responding produced by a ground-based model for exposure to cosmic raysBrain Res. 1036:122-129.

[xviii] Joseph, J. A., Shukitt-Hale, B., and Willis, L. M. (2009). Grape juice, berries, and walnuts affect brain aging and behaviorJ. Nutr. 139:1813S-1817S.

[xix] Asami, D. K., Hong,Y. J.,Barrett, D. M., and Mitchell, A. E. (2003).Comparison of the total phenolic and ascorbic acid content of freeze-dried and air-dried marionberry, strawberry, and corn grown using conventional, organic, and sustainable agricultural practicesJ. Agric. Food Chem. 51:1237-1241.

[xx] Klopotek,Y., Otto, K., and B¨ohm,V. (2005). Processing strawberries to different products alters contents of vitamin c, total phenolics, total anthocyanins, and antioxidant capacityJ. Agric. Food Chem. 53:5640-5646.

[xxi] Ngo, T., Wrolstad, R. E., and Zhao, Y. (2007). Color quality of Oregon strawberries-impact of genotype, composition, and processingJ. Food Sci. 72:C025-C032.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.
LeanMachine Note: Strawberries may also be sprayed, so organic is best, and wash before eating.

Effectively lower blood sugar levels with a natural plant extract

Reproduced from original article:
www.naturalhealth365.com/lower-blood-sugar-levels-3178.html

help-blood-sugar-levels

(NaturalHealth365) According to the U.S. Centers for Disease Control and Prevention, close to 30 million Americans – almost one in ten – have type 2 diabetes. And, an alarming 84 million people have prediabetes – elevated blood sugar levels that can progress to diabetes (with possible complications including kidney disease, heart disease and stroke).

In light of this growing epidemic – and amid the pressing need for effective, non-toxic interventions – a just-published study offers hope by showcasing the ability of clove extracts to safely lower elevated blood glucose levels.

Cloves, a common cooking spice, have been utilized in Ayurvedic and Asian healing systems for centuries to treat digestive disorders, influenza and tooth pain.  To learn how these potent little dried flower buds can help normalize and regulate blood sugar – and help to ward off diabetes – keep reading.

Alert: Prediabetes affects over half of all those over 65

What is prediabetes, exactly, and why is it dangerous?  Prediabetes exists when glucose (blood sugar) levels are elevated (over 100 mg/dL), but fall short of 125 mg/dL – the conventional medical threshold for diabetes.

The condition can often be reversed with weight loss and increased physical activity – but experts point out that roughly 30 percent of people with untreated prediabetes will go on to develop diabetes within three to five years.

And, although prediabetes doesn’t meet the medical standard for diabetes, it can still feature dangerous after-meal blood sugar elevations, or “spikes.” These spikes are associated with harmful effects such as neuropathy (nerve damage to feet), vision loss, kidney damage and heart disease.

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In people over 65, post-meal blood sugar spikes appear to impede cognitive function, as well.  Not particularly good news for those who may already be coping with varying degrees of age-related mild cognitive impairment!

It’s official: Cloves promote better blood sugar control

In a new study published in May 2019 in BMC Complementary and Alternative Medicine, researchers evaluated the effects of clove extracts on adult volunteers.  The participants were divided into two groups: those with normal fasting glucose and those with prediabetic fasting glucose levels.

Fasting glucose levels are measured eight hours after ingesting food.  And, participants were then given 250 mg of clove extract after a meal for 30 days.

The team found that the clove extract lowered fasting glucose levels of the prediabetic participants – but did not alter the desirable fasting levels of those with normal glucose.  In fact, the clove extract reduced after-meal glucose by 21.5 percent in the “normal” group – and by a substantial 27.2 percent in the prediabetic group.

The team concluded that cloves can be used to maintain healthy blood sugar levels, particularly in those with less-than-optimal glucose control.  It should be noted: that if cloves help to keep prediabetes in check, that’s highly significant – as prediabetes can increase the risk of heart disease and stroke, even when it doesn’t develop into type 2 diabetes.

New study confirms earlier research on the blood sugar-lowering effect of cloves

Researchers have long suspected that cloves could be useful in addressing diabetes.

Past studies have shown that cloves increase the secretion of insulin, the hormone that ferries sugar from the blood to the muscles. Previous research has also shown that clove extracts benefit liver function – essential in blood sugar control – as well as antioxidant status.

And, in 2006, Pakistani researchers found that clove extracts improved the function of insulin and lowered glucose levels in people with type 2 diabetes.  Cloves were also found to reduce harmful LDL cholesterol – but did not reduce levels of beneficial HDL cholesterol.

By the way, the amount used in the Pakistani study was modest: the equivalent of one to two cloves a day.

Cloves reduce blood sugar with three different mechanisms

Cloves, scientifically known as Syzgium aromaticum, are antimicrobial, anti-inflammatory and strongly antioxidant.  In fact, researchers have reported that cloves contain 30 times more antioxidants than blueberries, often considered the “gold standard” of antioxidant foods.

Along with gallic and ellagic acids, catechin and quercetin, cloves are particularly rich in eugenol, a compound with antibacterial and analgesic effects.  However, some scientists credit a compound called nigericin in cloves with increasing the uptake of sugar and promoting the secretion of insulin.

Specifically, cloves reduce blood sugar by enhancing the uptake of glucose into muscle cells, by inhibiting digestive enzymes from releasing the glucose from refined sugars and starches, and by inhibiting the production of glucose in the liver.

This three-pronged response makes cloves uniquely helpful for decreasing insulin resistance and managing blood sugar.

Reverse prediabetes with healthy lifestyle choices

Experts say that the current epidemic of diabetes and prediabetes is driven by obesity, poor nutrition and a sedentary lifestyle.

An organic diet (high in antioxidant-rich vegetables, fruits and unrefined grains and free of refined sugars, GMOs and unhealthy fats) just might be your best bet for preventing diabetes – along with maintaining a healthy weight and getting sufficient exercise.

As the latest study shows, cloves may also be helpful in managing blood sugar.

Of course, clove extracts are available in tablets and tinctures.  You can also make clove tea by boiling a teaspoon of powdered cloves for 8 to 10 minutes, straining and cooling. For an added health benefit, add cinnamon and cardamom.

Many studies used a teaspoon (2 grams) of ground cloves, and natural healers may recommend amounts in this range.

As always, consult with your integrative physician before supplementing with cloves – especially if you are already taking medications to control blood sugar.  Note: of course, don’t stop taking prescribed medications unless specifically advised to do so by your physician.

As the scientists noted in the groundbreaking new clove study, type 2 diabetes is a “tremendous public health issue.”  And, spicy, aromatic clove buds just may hold the secret to better blood sugar control – thereby striking a blow against this dangerous disease.

Sources for this article include:

CDC.gov
LifeExtension.com
NIH.gov
Healthline.com

Chemotherapy can trigger drug-resistant leukemia upon relapse

Reproduced from original article:
www.naturalhealth365.com/chemotherapy-leukemia-3182.html

leukemia-side-effect

(NaturalHealth365) Greater than 3,000: that’s how many new cases of acute lymphoblastic leukemia (ALL) are diagnosed every year in the United States. According to the Centers for Disease Control and Prevention, ALL is responsible for 20% of all cancers in people younger than 20 years old.  And, sadly, the Dana-Farber Cancer Institute finds that up to 1 in 5 kids who undergo chemotherapy for ALL will relapse – even if they initially receive a complete remission of the cancer.

Now, new research reveals a frightening correlation: the chemotherapy itself may be responsible for many of these cancer relapses!

Breaking cancer news: Chemotherapy responsible for 20% of leukemia relapse cases

ALL is a type of cancer that develops when a person’s bone marrow begins to overproduce white blood cells called lymphocytes. The disease tends to progress quickly, causing the new lymphocytes to be immature. When the immature lymphocytes begin to outnumber the mature white blood cells, it becomes difficult for a person to fend off infections.

ALL is the most common childhood cancer.  While outcomes are generally favorable, anywhere from 15 to 20% of children experience relapse of their leukemia, and the disease can be fatal.

A new paper published in the journal Blood suggests a disturbing explanation for some of these cases of relapse – what the authors call “chemotherapy-induced drug resistance mutations.”

The researchers performed genome-sequencing in 103 young ALL patients with a history of cancer relapse. They discovered mutational “signatures” in about 20% of these patients that were consistent with chemotherapy drug resistance.

Do NOT ignore the health dangers linked to toxic indoor air.  These chemicals – the ‘off-gassing’ of paints, mattresses, carpets and other home/office building materials – increase your risk of headaches, dementia, heart disease and cancer.

Get the BEST indoor air purification system – at the LOWEST price, exclusively for NaturalHealth365 readers.  I, personally use this system in my home AND office.  Click HERE to order now – before the sale ends.

Based on their findings, the authors suggest that chemotherapy can induce certain genetic mutations and “facilitate a subset of pediatric ALL relapses.” They also suggest that less toxic therapies and more individualized approaches to cancer management should be undertaken.

Considering that the vast majority of people who die of ALL will experience a relapse first, the importance of this cannot be understated.  Unfortunately, this isn’t the only reason medical professionals are concerned about powerful chemotherapy drugs.

At least two other notable health risks are associated with chemotherapy beyond drug-induced relapse, research finds

Chemotherapy drugs are cytotoxic chemicals and are considered the main type of treatment for ALL and other cancers. These include powerful man-made drugs like cytarabine, doxorubicin, asparaginase, and methotrexate. These may be administered for up to two years or longer and can exact widespread effects on the body.

As an example, it’s well-known that chemotherapy often leads to debilitating side effects including nausea, an increased risk for infections, neuropathy, gastrointestinal distress, and trouble breathing. But as we’ve already reported here before, chemotherapy may also lead to other serious health problems, including:

Are cancer patients – or, in the case of ALL and other types of pediatric leukemia, the patients’ caregivers – being informed about these dangerous and potentially deadly effects of chemotherapy? Could we save the lives of hundreds of American children every year simply by exploring other cancer treatment options beyond the knee-jerk reaction to stick everyone on chemotherapy?

Based on the research, we think it’s possible – and we think it’s a conversation more medical professionals need to have.

Sources for this article include:

Eurekalert.org
Cancerresearchuk.org
Medicalnewstoday.com
Danafarberbostonchildrens.org
Ashpublications.org
Mayoclinic.org
CDC.gov

Vitamin D3

Written by Brenton Wight – LeanMachine, Health Researcher.

Health Facts on Vitamin D3 – the Natural Cure for all disease!

Why we need Vitamin D3
First, to help absorb calcium and other minerals to build strong bones with the help of Vitamin K2 that keeps calcium in bones instead of in blood where calcium plaques form.
Second, to build the immune system, in conjunction with gut bacteria – the other half of the immune system story.
Depending on which study we believe, optimal vitamin D3 can prevent between 50% and 90% of all cancers, as well as Multiple Sclerosis, and reduce the intensity or even cure almost every other disease.
If a drug company developed something that would do this, it would make headlines around the world and win a Nobel prize, and many billions of dollars would be saved in the health care budgets of countries everywhere.
If the entire population had optimal Vitamin D3 combined with a healthy diet, countless lives would be saved from cancer, many illnesses would disappear, most artificial replacements of hips and knees would not be required, thousands of people clogging up the nursing homes in their wheelchairs would be out playing tennis and leading active, productive lives.
Have I convinced you yet that just a few dollars for a year’s supply of super-strength 5000 IU Vitamin D3 would be a good investment in your future?
If not, then perhaps you should go and reserve that spot in the nursing home, and pick out the burial plot while you’re at it!

Benefits of Vitamin D3

Studies show that Vitamin D3 has cancer inhibiting properties, especially breast, prostate, pancreas, colon, skin cancer and leukaemia.
While millions are spent trying to find a cure for cancer, Vitamin D3 could be used to prevent cancer in the first place, at a cost equivalent to a drop in the ocean.
Vitamin D3 deficiencies can cause the following:
Colds and flu:
Vitamin D3 helps prevent or reduce severity of colds, flu, and almost every other infection. LeanMachine is living proof. After 10 years of taking Vitamin D3, no colds, no flu, no infections of any kind, not even a headache!
When we look at studies funded by drug companies who manufacture vaccinations, which are always biased in favour of the flu shot, the NNT (Number Needed to Treat) for the flu vaccine is 40, meaning that to protect one person from getting the flu, 40 people must receive the vaccination. Compare this with Vitamin D3, where the NNT is 33 in the average population, and in those people with D3 deficiency, the NNT drops to 4. In other words, for the average person, D3 is significantly better than the flu shot, and for those with low Vitamin D3, D3 supplements work 10 time better than the flu shot!
Most infections are naturally destroyed by our own immune system, mainly the T-cells, but T-cells need Vitamin D3 to operate correctly.
Studies funded privately, without the influence of the drug companies, have foud the flu shot to be even less effective, with those over the age of 65, or under the age of 2, or those on statin medications, all receiving NO statistically discernible benefit from the flu shot, and everyone else receiving a very marginal benefit such as a reduction in duration of illness of about 1 day.
On the downside, those taking the flu shot every year received less benefit (less protection), and actually INCREASED risk of coming down with a different strain of the flu!
More on vaccinations under the heading below.
OA (Osteoarthritis)
Osteoarthritis (OA)is the most common disease in people over age 50, more common than the common cold, and especially in women.
OA is directly linked to Vitamin D3 deficiency, and higher Vitamin D3 levels lower the risk.
Studies show that hip fractures in high risk population groups can be reduced by up to 40% by supplementing with Vitamin D3.
Partly because bones are stronger, and partly because people with good Vitamin D3 levels have much better balance and stronger muscles, so don’t fall over as much.

RA (rheumatoid arthritis) and MS (Multiple Sclerosis) appear to have the same link.

Obesity
Most Australians (two thirds) and others in Western society are overweight or obese.
Two thirds of people in Western society are also deficient in Vitamin D3, and this is no coincidence. There is a direct link between Vitamin D3 deficiency and obesity.
On average, the more Vitamin D3 deficient a person is, the more obese they are.
Healthy levels of Vitamin D3 are seen mainly in lean, healthy people.

Chronic pain
Chronic pain from any source can be reduced with Vitamin D3, even a simple headache, migraine, back pain, fibromyalgia, etc.
Many people with osteoporosis have chronic pain, typically lower back pain, often a sign of D3 deficiency.
Those people usually exercise less because of the pain, and insufficient exercise causes depression, worsens their osteoporosis, increases obesity, and their condition only gets worse.

Before 2010, LeanMachine suffered from headaches back pain and other pain, but no more. If I hit my thumb with a hammer, of course it hurts, and if I strain my back or another muscle, I feel stiffness that goes away in a day or two. But no other pain, no painkillers required, and in fact no painkillers of any kind kept in the house.

Cancer
Cancer is a devastating condition, but high levels of Vitamin D3 offer up to 80% or more protection, especially childhood cancers, breast, prostate, pancreas, skin and colon cancer.
A recent study confirmed that women with high levels of Vitamin D3 had about 85% reduced risk of breast cancer compared to those with the lowest levels of Vitamin D3.
Vitamin D3 is critical to the body’s production of GcMAF, a cancer-fighting protein that inhibits cancer metastasis, and is capable of reversing the devastating effects of cancer on the body. Vitamin D3 supports GcMAF synthesis, helping to shut down pro-cancer receptors and enzymes that encourage metastasis.
DBP-maf(Vitamin D3 binding protein-macrophage activating factor) is another protein reducing cancerous activity, which directly stimulates the immune response by suppressing angiogenesis (blood vessel growth) required for cancer cell migration and tumor growth. DBP-maf requires Vitamin D3 for transport in the bloodstream.

Depression
There are links between low levels of Vitamin D3 and depression.
For depression sufferers, LeanMachine recommends extra Vitamin D3 from sunlight because getting outside in the sun always lifts our mood. If we cannot get out in the sun, supplementation is a must.

Hearing Loss
Vitamin D3 deficiency weakens our bones, but when the three tiny bones (hammer, anvil and stirrup) in the ear become weak and spongy, attenuation of sound transmission results in hearing loss.

Allergies
Recent studies show that children with allergies have a high chance of being deficient in Vitamin D3, and those with the worst allergies, are over 80% likely to be deficient in vitamin D3.

Heart disease
The number one killer of Western society people is still cardiac disease.
Vitamin D3 deficiencies bring on high blood pressure, stroke and heart attack.
Number two is cancer, so we can alleviate both killers easily by eating a healthy diet and getting enough Vitamin D3 from sunlight and/or supplements.

Type 1 diabetes

Pregnant women who are deficient in Vitamin D3 are far more likely to produce offspring with Type 1 diabetes.
Any child deprived of sunlight in the first few years of life also has a far higher risk of type 1 Diabetes.

How do we get Vitamin D3 ?

We get Vitamin D3 from the sun, but we need the basic building-blocks in the body first.
The normal process of Vitamin D3 metabolism can be stopped by the deficiency of one single nutrient, so a healthy, nutrient-rich diet is essential.
In particular, we need cholesterol, which has been demonised for decades. More on this later.

Vitamin K2 – No Bones without it

Some people say we need Calcium for strong bones, but we get plenty of calcium from the diet, and we can absorb calcium with no problems as long as we have enough Vitamin D3.
No vitamin D3 means no calcium absorption, so adding more calcium to the diet without vitamin D3 means potential for calcium to form as plaque in our arteries, kidneys or other places where it will only damage the body.
Vitamin K2, which comes from animal products such as chicken, cheese, butter, eggs, etc, can help build bones by directing calcium to bones and teeth where it belongs, and helps keep our arteries, kidneys and other organs free from calcium.
The only vegetable source of Vitamin K2 is Natto (fermented soy), which explains why Japanese post-menopausal women have much stronger bones than Western women, as Natto is part of the traditional Japanese diet.
Vitamin K2 is not to be confused with Vitamin K (or K1), which is required for effective blood clotting, but not as effective as Vitamin K2 for bones, but still desirable in the diet.
K1 comes from intestinal bacteria as well as from green leafy vegetables like kale, spring onions, brussels sprouts, cabbage, broccoli, basil, asparagus, also prunes.
For vegetarians or vegans, supplementation of Vitamin K2 is essential as well as D3 for healthy bones. Vitamin D3 metabolism is complex, where each essential and critical nutrient provides the path to the next step, and one missing link in the chain will stop the entire process.
So it is no surprise that a third of our population is deficient in Vitamin D3, and around 90% are less than optimal. Unfortunately, these are the people who are at the highest risk of cancer.

Importance of Diet

Vitamin D3 cannot form without basic nutrients for the multi-stage process and this explains why so many people are deficient.

D3 – A Vitamin or a Hormone?

The answer is both.
It is a hormone (a chemical messenger) because it controls cells, organs, muscle and bone in everyday function, and because the body can manufacture it with sunlight exposure on skin.
It is a vitamin because it binds calcium so we can absorb it, as we humans cannot digest calcium without Vitamin D3, which maintains calcium and phosphate concentrations in the blood, providing minerals for bones, nerves, muscles, immune function, and lowers inflammation.
Many cell functions are controlled in part by vitamin D3, aiding in weight loss, blood glucose regulation, metabolism, and essential fatty acids (Omega-3) processing.
There is no point taking calcium or omega-3 foods or supplements without a good supply of Vitamin D3.
Almost every cell in the body has Vitamin D3 receptors, so Vitamin D3 is a crucial nutrient.
Vitamin D, D2 or D3?
The terms Vitamin D and vitamin D3 are used interchangeably here. D3 is the correct and natural Vitamin D.
D3 exists in the body as the storage form 25(OH) and the active form 1,25 2(OH). Vitamin D2 (ergocalciferol) is an artificial version of Vitamin D3 (cholecalciferol), or vitamin D coming from some foods.
D2 has very low affinity for DBP (vitamin D binding protein) so it cannot be easily stored and should never be used.
Firstly, D2 has nowhere near the healthy properties of D3 (cholecalciferol), and secondly, D2 tends to block absorption of the real D3.
Many foods come “fortified with vitamin D” but this is invariably an artificial D2 with poor benefits.
Some early medical studies on vitamin D used inferior synthetic D2 which is toxic at much lower doses, and unfairly discredited the real D3 which was not even being used in the studies.

How is Vitamin D3 made?

We get vitamin D3 from sunlight, food or supplements.
D3 from sunlight
Most people know we get Vitamin D3 from sunlight, but there is a multi-stage process involved.
Production starts in the liver, which makes 7-dehydrocholesterol, which then migrates to the skin to be altered by UVB (ultra-violet light in the B range) to become pre-vitamin D3.
This is carried back to the liver to be mediated by an enzyme (25-hydroxylase) to become 25-hydroxyvitamin D, where a hydroxy (OH) molecule is added to build the storage form 25(OH).
This is then transported to the kidneys to be mediated by yet another enzyme (1-alpha-hydroxylase) to finally become calcitriol, where a second hydroxy (OH) is added. This is the active form of vitamin D3, also known as cholecalciferol or 1,25 dihydroxyvitaminD3 or the active form 1,25 2(OH). Dihydroxy means that the D3 molecule has two OH molecules added, one from the liver and a second from the kidneys.
Vitamin D3 is carried in the blood by DBP (vitamin D-binding protein).
This entire process takes around 15 days, so if we shower every day, we “wash off” most of the pre-vitamin D, so morning showers are best, allowing the pre-vitamin D to start the migration back to the liver before the next shower.
And a day at the beach won’t help our vitamin D3 if we go for a swim, and worse if we get sunburnt!

Statins rob our Vitamin D3

As we age, we lose the ability to synthesise vitamin D from sunlight, and those on statin medication (half the aged population) cannot make 7-dehydrocholesterol, co-enzyme Q10, Cholesterol Sulfate and other important requirements for the body, because when statins slow the liver production of cholesterol, all of the above are affected.
No one should ever take a statin drug (Lipitor, Crestor, Simvastatin and others) other than exceptional circumstances, as they generally do much more harm than good.
Independent studies show that while some deaths from heart disease are reduced, deaths from ALL OTHER CAUSES is INCREASED by statin medication! Taking statins, we will generally not live one day longer, and will have a poorer quality of life.
Also as we age, we generate less stomach acid, losing the ability to take in B12, Methyl Folate (never Folic Acid!), Vitamin K2 and other nutrients that vitamin D requires to do it’s job. If we get reflux or heartburn, doctors normally prescribe Nexium or antacids, which may relieve symptoms short-term, but only make the problem worse. The best way to cure heartburn is to eat less, and eat an alkaline-forming diet, but that is another story in my Alkaline Diet article.
Those who dress fully covered for cultural reasons or those with dark skin always need more vitamin D.
Annual blood tests for vitamin D3 are advisable if taken at very high doses as excess levels can become toxic.
For adults, toxic levels for vitamin D3 are generally not seen unless we take in some 40,000 IU daily for many weeks.
Vitamin A can also be toxic in high levels, but if A and D are taken together, the toxic levels are some 5 times higher for both A and D, giving a huge margin of safety, so old “toxic levels” should really be called “imbalance levels”.
Another factor is Vitamin K2, discussed later.

Other things that Steal our Vitamin D3

Being overweight – the more overweight we are, the less bioavailable Vitamin D3 becomes. But if we take Vitamin D3 supplements and/or get more sunshine, this will assist our weight-loss efforts!
Being old – as we age, our ability to absorb D3 from sunlight and from food reduces, so supplementation becomes more essential.
BPA (Bisphenol A) – BPA (Bisphenol-A) and other endocrine-disrupting chemicals reduce our Vitamin D3 levels. Avoid foods in plastic or cans and use glass containers.
Liver problems – a poor liver produces less bile, which reduces absorption of Vitamin D3. Look after the liver – avoid excess alcohol and eat a healthy diet of quality fats, few carbohydrates, and low to moderate protein.
Kidney problems – as kidney disease gets worse, so do Vitamin D3 levels. Look after kidneys by drinking plenty of clean water and eating a healthy diet
Gut bacteria – these 100 trillion organisms are a major component of our immune system, and also aid in absorption and processing of minerals and vitamins, including Vitamin D3. People with celiac disease, chronic pancreatitis, IBS (irritable bowel syndrome) or Crohn’s disease, or those taking antibiotics, will all have reduced D3, so essential supplements are Vitamin D3 and probiotics.
Slip, Slop, Slap in the face campaign – this disastrous campaign has been running for over 30 years in Australia, costing the taxpayer many millions of dollars, and has caused many more millions in extra health care, more disease, and many more lives lost.
True, reduced sunlight has reduced the number of mostly harmless skin cancers such as basal cell carcinoma and squamous cell carcinoma which are easily treated, and rarely turn into something more serious (less than 1% of cases).
But the number of MELANOMA cancers – the real, deadly kind, has DOUBLED, but this fact has been hidden by the Australian Cancer Council who are behind the Slip, Slop, Slap campaign! The primary reason, of course, is lack of Vitamin D3 due to reduced sunlight, reducing immunity.
Melanomas also appear on the soles of feet, in armpits and other places where sunlight is very limited, but so-called “specialists” still blame the sun!
The science cannot be denied. The closer one lives to the Equator, the less chance of any type of cancer, a proven fact.

Too much sunlight?

If we get D3 from sunlight, then surely if we spend all day in the sun, like construction workers and other outdoor activities, we should get plenty?
Wrong. After we spend around 10 to 20 minutes in the sun in the middle of the day (90 minutes for dark-skinned people), we reach a point where the body will no longer synthesise any more vitamin D3.
This is the way the body is designed to prevent toxic levels from building up, and also the reason why we get a tan – to prevent too much vitamin D3 from the sun.
If our skin starts to get the slightest shade of pink, it is time to cover up or seek some shade, as more sun will only then cause damage, with no extra vitamin D3 past that point.
And if we get a healthy dose of sunlight one day, we can happily work inside the next day, as it may take 2 days to build new skin resources for more absorption.

The Morning Myth

The cancer society and other “health” organisations all say the we should avoid the sun in the middle of the day, and only go out in the morning or the evening when the sun is low in the sky. Wrong again!
This is actually the complete reverse of the truth!
The sun produces ultra-violet rays in three bandwidths, named UV-A, UV-B and UV-C, each with different properties.
UV-A
We get UV-A from all sunlight, no matter what time of day, and it passes through cloud and glass, and this kind travels deeper into the skin, causes skin damage and ZERO vitamin D production.
We can sit by a window or in a car with windows up, on a hot sunny day and never get any vitamin D.
We can be outside all day when there is cloud cover, but we will never get any vitamin D.
All we get from UV-A is skin damage.
UV-B
We get UV-B ONLY from a clear blue sky, and ONLY when the sun is HIGH in the sky. This is the “good” sunlight, as this is the ONLY kind that gives us vitamin D.
When the sun is lower in the sky, most UV-B is absorbed in the atmosphere leaving little or none for our benefit.
We need 10 minutes a day (fair-skinned) to 20 minutes a day (tanned) with the sun high in the sky, no clouds, and no glass. This can give us all of the vitamin D we need, but for many, this is impossible.
For those living a long way from the equator, or out of the tropic areas in winter, those working shifts or indoors, those who cover their entire bodies for religious reasons, or slap on sunscreen, those who have very dark skin, those on statin medication, those on a poor diet, those confined to hospitals or nursing homes and others who mistakenly believe the sun is evil, will never get enough vitamin D.
Vitamin D is fat-soluble, meaning that if we get plenty one day and miss the sun for a few days, we will still be able to call on our vitamin D reserves stored in fat cells.
Of course, UV-B will still damage our skin if we stay out in the sun too long.
UV-C
UV-C rarely gets to Earth as it is almost completely absorbed in the atmosphere, so is of little concern unless you are an astronaut.

Why we NEED sunlight, more than just for Vitamin D3

The human body is designed to thrive in sunlight, and it is not only the Vitamin D3 benefit.
A 20-year study of over 29,000 people found that those avoiding sun exposure had double the death rate from all causes!
This study did not measure D3 levels, but results from other D3 studies show that the high death rate from insufficient sun exposure can not be accounted for only by low Vitamin D3.

We also get Cholesterol Sulfate from sunlight on the skin.
Cholesterol sulfate protects red blood cells from breaking up. Without enough cholesterol sulfate, we get a condition called hemolysis, where the red blood cells die prematurely, spilling their contents into the blood.
Without sulfur, and without the sun, we cannot make cholesterol sulfate, a molecule which is both fat-soluble and water soluble, which is essential for the body to distribute cholesterol and sulfur throughout the body.
All artery walls have an endothelial lining, and these endothelial cells cannot work correctly when depleted in sulfate. They cannot control what gets into and out of cells, which promotes cardiovascular plaque.
Cholesterol Sulfate, in conjunction with it’s nitric sister, eNOS, determines how thick or thin or blood becomes. Sulfate makes it thicker, nitric makes it thinner, and this automatic regulatory system works very well as long as we have supplies of both, for which we need sunlight.
Interestingly, one thing that messes up these molecules is glyphosate (“Roundup” and other weedkiller trade names) so this is a good reason to avoid all GM (Genetically Modified) foods, which are all heavily sprayed with glyphosate.
Sulfur is incredibly important for health. Cholesterol sulfate protects against bacterial and virus infections and strengthens the immune system.
Cholesterol sulfate is essential for babies. Women normally have about 1.5 units of cholesterol sulfate in the blood, but in pregnancy, levels rise in the villi of the placenta to around 24 units!
Foods high in sulfur include eggs, beef, garlic, onions, sprouts, asparagus, kale, coconut oil, olive oil, but only where they are grown or raised in sulfur-rich soil (think organic).

Vitamin D sulfate is also made from sunlight, and is both water and fat soluble, so it can go anywhere in the body, distinct from the regular fat-soluble Vitamin D3 I have been talking about. Same with cholesterol sulfate. Not only is it both water and fat soluble, it can travel through the body on it’s own, where many other substances need to be “carried” by cholesterol wherever they need to go.
If we want healthy blood, we MUST have sunlight!
Humans make several other important peptide and hormone “photoproducts” when skin is exposed to UVB sunlight:

  • β-Endorphins are natural opiates that induce relaxation and increase pain tolerance
  • Calcitonin Gene-Related Peptides are vasodilators (expand blood vessels) that protect us from hypertension (blood pressure), vascular inflammation, and oxidative stress
  • Substance P is a neuropeptide that increases blood flow and also regulates immune system response to acute stressors
  • Adrenocorticotropic Hormone is a polypeptide hormone, controlling cortisol (stress hormone) release by the adrenal glands, regulating immune system and inflammation
  • Melanocyte-Stimulating Hormone is a polypeptide hormone, reducing appetite, increasing libido, and increasing skin pigmentation

Sunlight contains a beneficial EMF (electromagnetic frequency) that is essential for health.
40% of sunlight is infrared, and the red and near-infrared frequencies interact with CCO (Cytochrome C Oxidase). CCO is a protein in the inner mitochondrial membrane, also part of the electron transport chain. CCO is a chromophore (a molecule that attracts and absorbs light), so sunlight improves ATP (the generation of energy). The optimal wavelengths for CCO are red at 630 nm to 660 nm (nanometers) and near-infrared at 810 nm to 850 nm.
LeanMachine gets sun exposure as often as possible. Others afraid of the sun may consider photobiomodulation therapy (use of near-infrared light treatment).
UVA exposure is generally considered harmful, as this is the most damaging kind of exposure for skin with no ability to generate Vitamin D, however there are benefits such as releasing NO (Nitric Oxide), discussed above. An important cellular signaling molecule that dilates blood vessels and reduces blood pressure.
This is closely tied to another molecule, eNOS (endothelial nitric oxide synthase) which regulates the “thickness” of blood. When blood becomes too thick, eNOS makes more nitric oxide which expands blood vessels and thins the blood. When blood is too thin, eNOS makes more sulfate. Sulfate is essential for the endothelial lining of all blood vessel walls. If we are low in sulfate, the wall can start breaking down and clots start to form to repair the damage. We can get more sulfur in the diet from onions, garlic, broccoli, egg yolks and other foods, or by supplements such as MSM (MethylSulfonoyl Methane) but we still need sunlight to make cholesterol sulfate which can be distributed through the body to keep us alive!

Apart from photoproducts, nitric oxide and cholesterol sulfate production, sunlight is essential for our circadian rhythm (body clock). Sunshine activates neurons in the suprachiasmatic nucleus of the hypothalamus, sending signals to the pineal gland which regulates production of the hormone melatonin. When the circadian rhythm is upset, melatonin and other hormone production is disrupted, leading to mood problems, poor cognition (thinking), metabolic syndrome (leads to diabetes) and increased risk of cancer.

Tanning Beds

Tanning beds are famous for increasing risk of melanomas, the most deadly form of skin cancer.
Tanning beds have been outlawed in all States of Australia, except in the Northern Territory, where they are still legal, but there are no commercial solariums there because the tropical climate makes sunlight tanning easy. However, this is seen by some as a knee-jerk reaction by politicians to win votes.
Most tanning beds produce UV-A and UV-B radiation, but some better units are available which produce only UV-B, which are much safer if used correctly.
Staying too long in even a quality tanning bed will cause skin damage, a precursor to many forms of skin cancer. Tanning beds that emit high levels of UV-A should be avoided completely.

Vitamin D3 from food

We get some vitamin D from the diet. Eggs, fish, cod liver oil are all good sources, and also come naturally with Vitamin A, but it is almost impossible to get enough D3 from the diet, so we must top up our D3 from sunlight or supplements or both. Milk contains some vitamin D, but calcium and vitamin D in milk are very poorly absorbed. Asian women are more likely than white women to be diagnosed with osteoporosis, so doctors claim this is caused by low milk consumption, but Asian women are much less likely to have a hip fracture (the worst kind), indicating that traditional DEXA scans (bone density tests) do not mean much, as dense bones are often not as strong as less dense but more flexible bones.
Africans generally have stronger bones than caucasians, even though they get less vitamin D3 from sunlight. They appear to be much more sensitive to the sunlight they do receive.

VitaminD3 from supplements

Most Vitamin D3 sold in Australia from chemist shops or supermarkets contain 1000 IU which may be enough to prevent rickets in young people, but is nowhere near optimum for immunity and bone strength, especially in older people, and not enough for anyone except small children to have an optimal immune system.
LeanMachine recommends Vitamin D3 5000 IU daily for almost a year’s supply, and this is the cheapest health insurance anyone can buy!
Vitamin K2 is also recommended, as this combination helps put calcium where it belongs, in bones and teeth, and reduces calcium buildup in blood vessels (arterial plaque).
Vitamin A is also recommended for health benefits as well as to eliminate any chance of toxicity.

No Cholesterol means no Vitamin D3

As explained above, cholesterol is the building-block for vitamin D3, also for every hormone in the body and many other functions.
About half the adult population over 60 in Australia and the USA is taking statin medication.
Sold under many names including Simvastatin, Lipitor, Advicor, Lovastatin, Mevacor, Vytorin, Zocor, Lipex, Simcor, Crestor, Pitavastatin, Pravastatin, Rosuvastatin, Fluvastatin, and Cerivastatin (withdrawn 2001).

The Lies about Cholesterol

Statins do lower cholesterol, but we NEED cholesterol, it is NOT the enemy it is made out to be. Yes, cholesterol is found in a badly inflamed body, but this is because the liver makes more cholesterol to repair damage caused by the inflammation, which is the REAL cause of poor health.
Statins reduce cholesterol by preventing the liver from producing as much cholesterol, but the job of the liver is to make cholesterol as required.
If we eat cholesterol foods (such as meat or eggs) the liver makes less, if we eat no cholesterol (such as a vegan diet), the liver makes more, which is the way it should be.
When statins are used, they attempt to shut down this natural process, and in so doing, also shuts down co-enzyme Q10 which is vital for healthy muscles.
And the heart is the most important muscle in the body – why clobber it with statins?
Statins also stop production of 7-dehydrocholesterol, so then we get almost zero vitamin D3 from sunlight.
Statins have shown no benefit to women whatsoever in many studies.
For men who have had a heart attack, statins have shown a slight reduction in deaths from future heart attacks, but in all patients, statins cause an INCREASE in deaths from all other causes!
Because statins knock out our Co-enzyme Q10 (often called the spark-plug for the heart), the patient can suffer extensive muscle damage, causing pain, reduced mobility and even death.
Drug companies say they have no idea what causes this increase in death from statins, but the answer is obvious to me – low vitamin D3!
Studies show that treatment with one fish oil capsule daily prevented 9% of deaths in cardiac patients over 4 years, while those given the Crestor statin drug had an INCREASED death rate of 1% over the same period.
The Framingham study, the biggest and longest study ever, showed that those with the lowest cholesterol died first, and those with the highest cholesteol lived longest!
But the drug companies continue to perpetuate these cholesterol lies to maximise profits from their biggest-selling drug.

How much D3 do we need?

The older we get, the more vitamin Vitamin D3 we need.
The only way to know how much we have is by a blood test, because ethnic background, skin colour, amount of tan, food, medication, supplements, geographic location, sun exposure, clothing, sunscreen, exercise, BMI and many other factors determine how much Vitamin D3 we absorb and retain.
Vitamin D3 is a fat-soluble vitamin, so daily levels do not vary much, as every fat cell in the body can store D3.
Always ask the doctor for a printed copy of your results so you can compare with any previous test and also get a true reading.
Unfortunately, most Australian labs say we need 60 to 160 nmol/L of D3, which is inadequate. Better labs say 75 nmol/L is the minimum, but we need more.
Values above 60 will prevent us from getting rickets, but will not give us good immunity.
For optimal immune system function, we should aim for the high end of the range of 125 to 175 nmol/L.
If we are battling cancer or some other serious disease, we should aim for 175 to 250 nmol/L but this requires careful monitoring and extra Vitamin K2 and Vitamin A to prevent toxicity.
Supplement values vary, and the RDA (recommended Daily Allowance) of 60 IU was alarmingly too low, and changed to 400 IU, originally determined as the minimum amount to prevent rickets.
Even the 400 IU allowance typically gives a blood test of 40 to 60 nmol/L which may barely stop rickets but will not provide a strong immune system.
Conservative studies determine that infants less than one year old need 400 IU daily, 1 year to adolescents need 400-600 IU daily, adults need 400-600 IU daily, and adults aged over 70 years need 400-800 IU daily.
More modern studies recommend babies take 400 IU, children 1000 IU, adults 4000 IU, and those over 70 may need 8000 IU daily.
Small doses are fine for strong bones, but for a strong immune system to ward off all disease, high doses are a must.
LeanMachine has taken 5000 IU daily for over 10 years, and has zero colds, flu or any other illness, not even a headache!

But don’t I get my Vitamin D3 from Milk?

Sorry, but you do not!
I was told to drink milk as a youngster, some 6 decades ago, and milk does indeed contain vitamin D and calcium, but these and other nutrients in milk are poorly absorbed in the gut.
Worse, pasteurised milk has most of the nutrients heated out of it, and homogenisation is very BAD for our health.
Homogenisation is a process making each fat globule 10 times smaller than normal, to save us the trouble of shaking the milk container to disperse the cream. The problem then is that these tiny fat globules then enter the bloodstream through imperfections in the gut lining, often referred to as “leaky gut syndrome”. When raw milk fat enters the blood directly like this, the immune system detects this as a foreign substance, and begins attacking these fat globules, and marks them as invaders. Now when we consume milk the regular way, and absorb it naturally through a healthy intestine, the immune system starts attacking this as well, as it has already been recognised as a foreign invader. The result: Allergies to Lactose, one of the main ingredients in milk, has reached epidemic proportions in the last few decades where homogenisation has become standard practice. Vitamin D3 can help stabilise an over-reactive immune system, but the only safe way to drink milk is to only use NON-HOMOGENISED milk. Most supermarkets have it, but you have to look past the big-name brands to find it.
In many countries it is against the law to buy non-pasteurised milk, but we can at least buy non-homogenised milk if we feel we must have milk (and we do not need milk).
Some Asian countries have diets where milk is non-existent, and their bones are stronger, and broken bones are rare.
We get more useful Vitamin D3 from broccoli and other fresh vegetables than from milk!
Milk is also BAD for our bones, as it is acid-forming in the body, and all acids in the blood cause an immediate reaction in the body to neutralise the blood acid (otherwise we die!).
This reaction, controlled by the parathyroid glands, leaches potassium, calcium and magnesium from bones, teeth and organs, the fastest way the body can neutralise the acid.
If we must drink milk (and we do not have to for a healthy diet) then the ONLY milk to buy is FULL CREAM, UNHOMOGENISED milk, which you can find at good supermarkets if you look hard enough.
The only better product is the milk straight from the cow, or better still straight from mother’s breast (most mothers will not be impressed if you ask for milk this way!)

Getting enough of the right Vitamin D3

Sunlight is still the best way to get enough Vitamin D3 and Cholesterol Sulfate, but for many, this can be difficult or impossible.
Supplements are the next best choice, but the supplements we buy at Chemist shops or supermarkets in Australia have only around 1000 IU of Vitamin D3.
They are also often combined with Calcium, which LeanMachine does NOT recommend, but that is another story.
While this is better than nothing, most people require 5 to 10 times this much to bring their levels to “optimum”.
For most health specialists, “optimum” means over 60 or 75 nmol/l (30 ng/ml), and if your results come in at over this threshold, the doctor will say you are fine.
However, true experts in this field say that truly optimum for a normal healthy person for immunity to disease, is between 125 and 175 nmol/L (50 – 70 ng/ml).
For those recovering from a serious disease, optimum should be 175 to 250 nmol/L (70 – 100 ng/ml).
Vitamin D3 can be toxic at high doses for extended periods, so continuous levels over 250 nmol/L (100 ng/ml) should be avoided.
Blood tests are advised for all very high-dosage patients.
People most at risk of deficiency are the elderly, those with with dark skin, those who cover their body with clothing or sun screen, or work night shifts or underground and never see the light of day, and those who live furthest from the equator or in cloudy climates.
Those at risk may need 10,000IU daily supplements, the rest of us can usually get plenty with 5000IU, and the very young who get plenty of sunlight on a regular basis may not require any.
Remember that we only get Vitamin D3 from sun in a blue sky when the sun is high, from the UVB (Ultra-Violet light in the “B” range”).
When the sun is low in the sky, or when there is cloud, or when the light comes through a glass window, UVB is blocked and we only receive UV-A which is the damaging, cancer-causing radiation with Zero Vitamin D3 benefits.
Other tests: Depending on the condition, the doctor may order other tests to check for liver and kidney disease as well as a full blood count.
A full blood test for Vitamin D3 is:
25-hydroxyvitamin-D (25-D or D2/D3) or 25(OH)D or simply 25-D
1,25-dihydroxyvitamin-D3, or 1,25(OH)2 D3, or 1,25 2(OH), or simply 1,25-D
Most doctors will only test for 25(OH)D which is the storage form, which is fine for most people.
For those suspected of having Sarcoidosis (a rare condition) then both must be tested, and vitamin D supplementation and sunlight should be avoided altogether unless the active form 1,25(OH)2 is tested low.

Vaccinations

There are many reports of children suffering from Autism and other serious conditions after vaccinations.
Vitamin D3 supplements should be taken for at least 1 week before any vaccination to reduce risk of unfortunate reactions.
Panadol, Panadeine, Paracetamol, Tylenol, Acetaminophen, Atasol, etc must NEVER be taken before or after any vaccination, even though doctors incorrectly recommend it to reduce pain and fever.
Autism rates in the USA are 1 in 45, while Autism rates in Cuba are 1 in 12,000.
A few decades ago, Austism rates were only around 1 in 200, before Panadol (Tylenol, Acetaminophen in the USA)
Cuba has a high vaccination rate of 97%, but the difference:
These over-the counter pain medications are prescription-only items in Cuba.
Of course, no drug company is interested in conducting a study where the result may be that their “safe and effective” product causes Autism, but as far as LeanMachine is concerned, Vitamin D3 reduces the risk of sickness from almost any disease.
Besides Autism, Panadol can destroy liver function (most patients on the liver transplant waiting list are there because of Panadol), and Panadol is also acted upon by enzymes which then destroy the body’s reserves of L-Glutathione, the natural “Master Antioxidant” in the body.
If you want your child vaccinated anyway, DO give them vitamin D3 and DO NOT give them any pain or fever medication.
A little fever is the body’s way to fight the toxins in the vaccination and the best way to deal with it is to let it run it’s course.
However, a very high fever can lead to convulsions, especially in small children. The best way to bring down a very high fever is to place the child in a cool to lukewarm bath and keep water over the skin using a sponge or cloth.
No drugs required, and much safer and more effective than any drug.
Better still, vaccinations can be avoided altogether for those with a strong immune system.
For more information on vaccinations, see this article: Vaccinations.

Autoimmune conditions

Allergies, hives, arthritis, lupus, psoriasis, rheumatoid arthritis, thyroid disease, multiple sclerosis, etc, are all autoimmune conditions.
Little help is available from medications which merely help to ease symptoms.
Vitamin D3 builds the immune system and protects us from colds, flu and other diseases, but Vitamin D3 is also an Immune Moderator, helping to dampen the effect of the immune system over-reacting, the cause of auto-immune disease.
Vitamin D3 can also help treat the cause of the symptoms, often Helicobacter pylori (H. pylori), found in over 70% of autoimmune patients.
H. pylori can invade the gut via contaminated water or food, or from contact with infected people or animals, causing gut inflammation, disrupting the immune system.
Vitamin D3 effectively destroys H. pylori and restores the immune system, often reducing allergy symptoms by 30% in seven days, and another 40% in 12 weeks.
H. pylori infects around 30% of adults in the western world, more if we are over 60 with low Vitamin D3 levels.
A blood test can give your D3 levels, but the lab will say 60 to 75 nmol/L is OK, but we need 125 nmol/L minimum to destroy H. pylori.
Mushrooms, eggs, wild-caught salmon, etc have natural Vitamin D3 but the modern Western diet is lacking in these. Mushrooms grown in the dark will have no vitamin D3, but 30 minutes of exposure to direct sunlight can generate significant D3 levels.

Vitamin D3
The latest science Says: “It’s not just about bones, it’s about your total well-being!
Professor Michael Holick:
We now think that maintaining adequate Vitamin D3 levels are important for decreasing the risk of prostate cancer, breast cancer and colon cancer.
There is some evidence that in young children if they are fortified with vitamin D3 from 12 months old it can reduce the risk of type 1 diabetes by 80%“.
Professor Philip Sambrook:
We have always thought it could not happen in Australia – it is too sunny a country. However, people do not get sunlight for various reasons and if you do not get some sunlight you do not make vitamin D3. We do not get it much in food any more so for that reason, deficiency is quite common. And the vitamin protects healthy cells while also killing cancer cells.”

LeanMachine online supplements

Note: This online supplement shop is now closed, but each product page contains a link to the best supplier of that product.

Disclaimer

LeanMachine is not a doctor, and everyone should consult with their own health professional before taking any product to ensure there is no conflict with existing prescription medication.
LeanMachine has been researching nutrition and health since 2010 and has completed many relevant studies including:

  • Open2Study, Australia – Food, Nutrition and Your Health
  • RMIT University, Australia – Foundations of Psychology
  • Swinburne University of Technology, Australia – Chemistry – Building Blocks of the
  • World
  • University of Washington, USA – Energy, Diet and Weight
  • Johns Hopkins Bloomberg School of Public Health, USA – Health Issues for Aging
  • Populations
  • Johns Hopkins Bloomberg School of Public Health, USA – International Nutrition
  • Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics I
  • Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics II
  • Johns Hopkins Bloomberg School of Public Health, USA – Principles of Human Nutrition
  • TUFTS University, USA – Nutrition and Medicine
  • TUFTS University, USA – Lipids/Cardiovascular Disease I and Lipids/Cardiovascular Disease II
  • Technical Learning College, USA – Western Herbology, Identification, Formulas
  • Bath University, England – Inside Cancer
  • WebMD Education – The Link Between Stroke and Atrial Fibrillation
  • WebMD Education – High Potassium: Causes and Reasons to Treat
  • Leiden University Medical Center, Netherlands – Anatomy of the Abdomen and Pelvis
  • MIT (Massachusetts Institute of Technology) – A Clinical Approach to the Human Brain

LeanMachine has now examined thousands of studies, journals and reports related to health and nutrition and this research is ongoing.

Updated 11th January 2020, Copyright © 1999-2020 Brenton Wight and BJ&HJ Wight trading as Lean Machine abn 55293601285