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76 Evidence-Based Health Benefits of Noni

© 3rd January 2020 GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here www.greenmedinfo.com/greenmed/newsletter
Reproduced from original article:
https://www.greenmedinfo.com/blog/76-evidence-based-health-benefits-noni
Posted on: Friday, January 3rd 2020 at 4:15 pm

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

Buyer beware: Eating Chinese garlic is a risky health decision

Reproduced from original article:
https://www.naturalhealth365.com/chinese-garlic-herbs-3250.html

chinese-garlic

(NaturalHealth365) It’s hard to find a reason not to eat garlic. Aside from the wonderful depth of taste, the long list of garlic health benefits offer plenty of incentive to add it to dishes of all types. No wonder it’s one of the world’s most popular herbs! But, as many consumers are learning, Chinese garlic is definitely something to avoid – as you’ll soon see.

The reason?  Garlic imported from this country is contaminated with potentially toxic chemicals – and the nation’s industry standards for cultivating garlic is leaving a really bad taste in people’s mouths.

Warning: Chinese garlic is contaminated with chemicals

Garlic is native to Asia and the Middle East and is a close relative to other vegetables from the onion family, including onions, leeks, chives, and shallots.  And, although within the U.S., Gilroy, California has been nicknamed the “Garlic Capital of the World” – world trade practices have changed quite a bit over the years.

Botanically speaking, garlic is a veggie because it comes from an edible plant with leaves and a bulb, although most people consider garlic to be one of the most popular herbs in the world.

Proven garlic health benefits include improved blood pressure, decreased cholesterol, strengthened immune system, and a deceased risk of blood clots. Garlic has also been shown to be an effective antimicrobial and can help naturally treat conditions like asthma, bronchitis, and upper respiratory infections.

Do NOT ignore the health dangers linked to toxic indoor air.  These chemicals – the ‘off-gassing’ of paints, mattresses, carpets and other home/office building materials – increase your risk of headaches, dementia, heart disease and cancer.

Get the BEST indoor air purification system – at the LOWEST price, exclusively for NaturalHealth365 readers.  I, personally use this system in my home AND office.  Click HERE to order now – before the sale ends.

But here’s the problem we as consumers are facing:

According to many health-related resources, about 80% of the world’s supply of organic garlic – yes, organic garlic – is shipped from China.  And natural health watchdogs are finding that the standards and methods of “organic certification” in China is iffy at best.

For one thing, China is able to produce such cheap garlic because of the way its cultivated. Many Chinese farmers use bleach (yes, bleach!) to whiten their “organic” garlic and kill bugs on the harvest.

Chinese garlic also tends to be exposed to cold temperatures, treated with compounds that will control or inhibit its growth after harvest, and over-stored – all of which will decrease the amount of allicin found in garlic, which is a natural compound that’s a major factor in garlic health benefits.

Also, consider the serious pollution problem that China is facing right now. High levels of air pollution throughout the nation is directly linked to hundreds of thousands of deaths each year, and investigations indicate that Chinese soil and water are both loaded with heavy metals like cadmium and arsenic as well as high concentrations of fertilizers and pesticides.

Some Chinese garlic farmers are even believed to use pesticides and herbicides that contain illegal and powerful neurochemicals like parathion and phorate.  There’s just no way that these harmful compounds aren’t getting into the food that the Chinese industry is shipping out to the rest of the world.

Really makes you wonder what’s on your plate, right?

Consuming garlic regularly will boost your health – here’s how to avoid low quality Chinese garlic

For what it’s worth, our team here at NaturalHealth365 uses organic garlic – grown locally.  But, if that’s not possible – you may want to look at buying your garlic from Christopher Ranch or McFadden Farms.  And, no, we are not being paid to suggest these companies!

Bottom line: no matter what garlic you go with, it’s clear that you should avoid garlic imported from China.

To help you avoid the troublesome herbs, here are a few tips:

  • Chinese garlic tends to be lighter and less bulbous (an ingenious if not disingenuous hack used to save on shipping costs)
  • Chinese garlic doesn’t taste as rich or bold as American organic garlic
  • Chinese garlic typically has its roots removed, whereas American garlic does not
  • Do your research on companies selling organic garlic powder – it’s possible that they are using imported garlic from China!

Lastly, for the ultimate peace of mind, buy your garlic from your local farmer’s market or consider growing it yourself.

Sources for this article include:

Boredomtherapy.com
Tokyofamilies.net
SFA-MN.org
Consumerreports.org
Healthline.com

TMG Benefits

TMG (Trimethylglycine) is a powerful nutrient, much like a vitamin, functioning as methyl donor, anti-oxidant, anti-inflammatory, energy booster, toxin remover, immune booster and more.
Also called betaine (first isolated from sugar beets) but different from Betaine Hydrochloride.

TMG the Methyl Donor

The TMG molecule comprises three methyl groups (CH3) joined to one molecule of glycine (C2H5NO2). The benefit of TMG is that it releases easily one, two, or all three of the methyl groups.
Releasing one methyl group then leaves behind DMG (Dimethylglycine) which is just TMG with only two methyl groups. Releasing all methyl groups leaves just Glycine, which is the smallest molecule of all of the amino acids, which allows it to go almost anywhere in the body, including crossing the blood-brain barrier.
DMG is considered a B-complex vitamin, shown to help:

  • Behaviour and speech in autistic children and adults
  • ADHD (Attention Deficit-Hyperactivity Disorder)
  • Neurological function
  • Reducing seizures
  • Stress tolerance
  • Oxygen utilisation
  • Liver activity
  • Athletic performance
  • Anti-aging
  • Anti-inflammatory
  • Anti-viral and anti-bacterial
  • Immune boosting
  • Shrinking tumours
  • Allergies
  • Chronic fatigue syndrome
  • Respiratory disorders
  • Alcoholism, drug addiction.
  • Cholesterol and triglycerides
  • Blood pressure
  • Blood glucose

Although DMG has all of these benefits, and is available as a supplement, LeanMachine recommends that people supplement with TMG as we then receive all of the benefits of DMG plus the benefit of 50% better methylation.

Methyl groups (CH3) are essential for millions of biochemical reactions every second in the body, these are a few examples:

  • Lowering homocysteine, an amino acid, which inflames arteries when levels rise, leading to “hardening of the arteries”. Homocysteine levels are a much better indicator of cardiovascular disease than cholesterol. High homocysteine is commonly caused by insufficient methyl groups. The body gets methyl groups from TMGActive FolateActive Vitamin B-12, SAM-eDMAEMethionineTaurine, Cysteine and Vitamin B-6.
    Other causes are mercury and copper toxicity. High homocysteine also causes methionine deficiency, in turn causing SAM-e (S-Adenosyl Methionine) deficiency which can lead to depression. Methionine is required for protein synthesis
  • Excess homocysteine also leads to osteoporosis, birth defects, cancer, ageing and free radicals, all helped by TMG
  • Methyl groups are required for the Phase 2, P450 liver detoxification pathway, a critical biochemical sequence of events. Fat-soluble toxins are joined to a methyl group, enabling a greater water solubility, then allowing the liver to remove them from the body. For toxins unable to be removed, methylation helps render them less toxic
  • TMG increases production of SAM-e, helping to reduce depression
  • TMG reduces risk of diabetes, as insulin release and insulin activity rely on methyl group donation
  • TMG donates methyl groups for protein synthesis (biosynthesis), the copying of genetic code from DNA to RNA (genetic transcription), then to the synthesis (formation) of every chemical in the body
  • TMG insufficiency causes biosynthesis slowing, telomeres shortening, and genetic errors (transcription errors) raises cancer risk from DNA mutations

The Methylation Process

This is a vital and most common chemical process in hundreds of essential chemical reactions, including:

  • Methylation is essential for manufacture of all the chemicals for the body
  • Stops certain viruses that could damage DNA
  • Stops the production of trophoblast (fast-growing cells that may lead to cancer)
  • Suppresses replication of DNA in areas where the body does not want it replicated
  • Important for neurological chemicals and blood chemicals
  • Corrects timing problems of the X chromosome in cell replication
  • Causea a genetic trait to come from only one parent, and not both
  • Prevents some genetic diseases
  • Helps prevent shortening of gene telomeres
  • Methylation is a primary method of removing toxins in the phase 2 liver detoxification system
  • Methylation converts toxins of all kinds from insoluble, less soluble or fat-soluble compounds into water-soluble compounds to allow excretion. Larger molecules are eliminated through the bile, smaller ones are excreted in the urine
  • Methylation is required for synthesis of dopamine and serotonin, improving mood, energy, wellbeing, alertness, concentration, and visual clarity
  • Methylation helps with liver detoxification
  • Methylation is required for conversion of homocysteine to methionine, which converts to other amino acids by various pathways
  • Methylation helps balance hormones such as estrogens, reducing risk of estrogen-related cancers
  • Reduces inflammation by removing toxins, balancing hormones, synthesising neurotransmitters and other methods
  • Methylation protects the mitochondria and adaptive energy production to stop us from becoming very tired
  • Restores SAM-e in spinal fluid, working as a methyl donor when restored by methyl groups
  • Methylation is required for the body to make CoQ10 (Coenzyme Q10), vital for heart health and energy production in the mitochondria
  • Methylation increases muscle mass, important in cancer and other wasting diseases, and for general health
  • Methylation may improve libido in some people

Who needs TMG?

Almost everyone needs supplemental TMG, even healthy people with a healthy diet, to provide enough methylation for modern life. Those subject to stress, toxins, cardiovascular disease, mental illness, depression, fatigue, exhaustion or almost any other medical condition, almost certainly need extra TMG.

Other benefits of TMG

The Parasympathetic System

TMG can improve the parasympathetic system, helping balance the autonomic nervous system. Hair mineral analyses show about half the population has an autonomic nervous system imbalance (sympathetic dominance), where the sympathetic (fight-or-flight) nervous system is “switched on” too often and too long, usually due to stress, causing many chronic health conditions. TMG may help reverse any imbalance, contributing to healing. Some doctors use “sympathetic dominance” in a different context such as “a sympathetic state of body chemistry” which is different from “sympathetic dominance” used here.

The MTHFR Defect

Almost half the people on Earth have the abnormal MTHFR gene expression, where the biosynthesis of folate is reduced, sometimes marginally, sometimes largely.
Often incorrectly called a “genetic defect” when it is actually a transcription error, polymorphism or abnormal gene expression where errors occur in copying the DNA code rather than a problem with the actual DNA code.
This is why Active Folate has benefits, as it is already in the (6S)-5-methyltetrahydrofolate form required by the body, while regular folate must be converted in the body to this form.
TMG can help supply the methyl groups where insufficent folate cannot. Active folate can be up to 700% more useful in the body, compared to regular folic acid. Note that folic acid is a cheap folate substitute used in many foods claiming to be “folate enriched” but folic acid may prevent absorption of real folate in foods or active folate supplements, and LeanMachine advises total avoidance of foods or supplements containing folic acid.

Antioxidant and anti-inflammatory

There are not many reports on these properties, but they do exist, possibly as a result of methyl group donation

Effects on the Brain

TMG has a positive effect on the brain, likely due to methylation and SAM-e production. Recommended for those at high risk for Alzheimer’s, dementia, Parkinsons, depression, anxiety, seizures, migraine headache, ADHD (Attention Deficit-Hyperactivity Disorder), MS (Multiple Sclerosis) and other brain conditions.

SAM-e Benefits

1. Heart Disease

SAM-e is used for heart disease, also for fibromyalgia, abdominal pain, osteoarthritis, bursitis, tendonitis, chronic lower back pain, ageing, CFS (Chronic Fatigue Syndrome), improving mental performance, liver disease, spinal cord injury, lead poisoning, to break down bilirubin or porphyrin (or precursors).

2. PMS

SAM-e is often taken for PMS (Premenstrual Syndrome) and a more severe form PMDD (Premenstrual Dysphoric Disorder).

IV use of SAM-e

IV (Intravenous) use of SAM-e is used for depression, osteoarthritis, AIDS-related nervous system disorders, fibromyalgia, liver disease, cirrhosis, and intrahepatic cholestasis (a liver disorder in pregnant women)

SAM-e Injections

SAM-e is often injected for fibromyalgia, depression, and Alzheimer’s disease.

Effects on Digestion

TMG aids digestion, again likely because of positive methylation throughout the body.

Glycine

Glycine is the component left over when all three methyl groups have been donated from TMG.
Glycine is the smallest of the amino acids and very important for collagen formation and many other functions. Collagen, the most abundant protein in the body, is used for connective tissue: Tendons, ligaments, cartilage, skin, nails, arteries, veins, etc. Without collagen, we could not stand up, our body would be a pile of mush on the floor!
Glycine, in large doses (up to 3000 mg daily), has been found helpful for sleep and alertness. Although not recommended as a first-line supplement for sleep, it may help if other supplements like Valerian fail to work. This may explain why TMG helps induce restful sleep in some individuals.

Natural sources of TMG

TMG is normally made in the body, but not enough when there are toxins present or the diet is poor or absorption of nutrients is a problem.
TMG can come from the diet. Foods high in TMG include broccoli, quinoa, spinach, lamb, chicken, and beets. A vegetarian or vegan diet tends to be very low in TMG. Foods high in TMG are usually also high in folate, and both are methyl donors.
However, most people do not eat enough of these foods, and even eating large amounts will not provide enough TMG for optimum health.

Risk factors for low TMG

Generally, the body cannot make enough, the modern diet is poor in TMG, and the number of pesticides, chemicals, heavy metal contamination uses up all TMG available.

  • Mercury is a poison that lowers TMG production in the body, and at the same time increases the need for TMG in the body. Almost everyone is mercury toxic now, as mercury is everywhere in the environment, especially in seafood and in dental amalgam fillings
  • Copper toxicity also interferes with TMG, and most people today are toxic from copper pipes, tapware, cookware even if blood or urine tests are negative. While copper is essential for the body to build hemoglobin in blood, we need Chelated Copper from food or supplements, not metallic copper from copper pipes and cookware. Zinc deficiencies cause accumulation of copper in the body, and women have a higher risk than men. Causes headaches, female organ problems, depression, anxiety, skin conditions. Too much zinc (and/or magnesium) competes with copper for absorption, often leading to a copper deficiency.

Supplements

Supplementary TMG is helpful for most people because of low body production, low in the diet, and higher requirements in our toxic world.
TMG 1000mg 100 tablets (most popular, best value).

Stress

Stress, inflammation, inflammation and some diseases increase our need for more TMG.

Dosage of TMG

  • Women: Up to 1000 mg daily
  • Men: Up to 3000 mg daily
  • Children: Less than adults, in proportion to body weight

There are no reliable guides or tests to determine TMG dosage, but the figures above should be a good starting point.
If the sodium/potassium ratio is low, extra TMG may help.
Do not overdose, as too much TMG may lead to over-methylation, causing fatigue, nausea, hair loss, dizziness or other symptoms.
Most people have no side effects from TMG apart from feeling better, getting better sleep and having more energy.
Cautions:
Do not continue a high dose for extended periods.
Children need proportionately less TMG than adults, depending on their size and weight, but babies generally do not need TMG. Older children may need about 250 to 500 mg daily.
TMG is available as tablets, liquid capsules or crystals. Some children and the elderly may have problems with swallowing tablets. TMG has a sweet taste, so TMG crystals can be simply added to food.
Some people have problems tolerating TMG, so they may need a smaller dose. Try reducing the dose until any symptoms disappear.
People who have unresolved resentments seem to have more problems taking TMG, as an enzyme is activated which can cause anger, fear, depression or anxiety symptoms. These symptoms disappear if the dose is reduced or eliminated, but if one can tolerate the symptoms, TMG may help the person resolve their issues of conflict.
Some reports suggest that too much TMG may cause diarrhea and nausea, and may raise cholesterol levels, so those with high cholesterol should keep the level monitored.

Poor Methylation

Several factors affect poor methylation, such as:

  • Raw vegetables are considered healthy, but cooked vegetables provide more dietary methyl groups
  • Sugars in any form appear to harm correct methylation, and are bad for our health anyway
  • Fermented foods are healthy, but are problem for methylation because:
    • Some contain aldehydes (toxic to the liver), including kombucha tea, kimchi, and most fermented grains
    • They contain ferments, which are bacteria or yeasts

    Safer fermented foods, eaten in moderation, include yogurt, kefir, miso and most good quality cheeses

  • Too much animal protein in the diet can cause high methionine and reduce methylation
  • Fighting inflammation or infections consumes methyl groups, requiring more methylation
  • Heavy metal toxicity, especially copper and mercury, interfere with methyl group formation
  • High-dose niacin or niacinamide cause the body to use up methyl groups to detoxify and excrete niacin through the liver. Doses less than 50 mg daily are generally tolerated well
  • Any liver toxins will reduce formation of methyl donors, also liver detoxification pathways require methyl groups, using up more methyl groups
  • Methyl donor production seems to decrease with age, so seniors need more TMG
  • Women of child-bearing age have much better methylation than men. Men always need more TMG than women

Methylation and Cancer

Cancer increases the need for methylating agents like TMG. People often die with cancer because they cannot eliminate their toxic metals and chemicals because of poor liver methylation, so toxins accumulate until death occurs.

Hair Mineral Analysis

More TMG may be required if a hair mineral test reveals:

  • High zinc level, which may indicate presence of hidden toxic metals
  • “Four lows pattern” meaning all four electrolyte minerals low: Calcium, Magnesium, Sodium, Potassium. Indicates impaired methylation
  • High mercury, becoming more common
  • High copper
  • High levels of the other toxic metals

These results indicate long-term toxic metal exposure.

LeanMachine online supplemments

Disclaimer

LeanMachine is not a doctor, and everyone should consult with their own health professional before taking any product to ensure there is no conflict with existing prescription medication.
LeanMachine has been researching nutrition and health since 2010 and has completed many relevant studies including:
Open2Study, Australia – Food, Nutrition and Your Health
RMIT University, Australia – Foundations of Psychology
Swinburne University of Technology, Australia – Chemistry – Building Blocks of the World
University of Washington, USA – Energy, Diet and Weight
Johns Hopkins Bloomberg School of Public Health, USA – Health Issues for Aging Populations
Johns Hopkins Bloomberg School of Public Health, USA – International Nutrition
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics I
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics II
Johns Hopkins Bloomberg School of Public Health, USA – Principles of Human Nutrition
TUFTS University, USA – Nutrition and Medicine
TUFTS University, USA – Lipids/Cardiovascular Disease I and Lipids/Cardiovascular Disease II
Technical Learning College, USA – Western Herbology, Identification, Formulas
Bath University, England – Inside Cancer
WebMD Education – The Link Between Stroke and Atrial Fibrillation
WebMD Education – High Potassium: Causes and Reasons to Treat
Leiden University Medical Center, Netherlands – Anatomy of the Abdomen and Pelvis
MIT (Massachusetts Institute of Technology) – A Clinical Approach to the Human Brain
LeanMachine has now examined thousands of studies, journals and reports related to health and nutrition and this research is ongoing.

Updated 9th January 2020, Copyright © 1999-2020 Brenton Wight and BJ & HJ Wight trading as Lean Machine abn 55293601287

Glutathione and NAC Play Crucial Roles in Health and Fitness


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2019/12/30/glutathione-nac-for-health-and-fitness.aspx

Analysis by Dr. Joseph Mercola Fact Checked image
glutathione nac for health and fitness

STORY AT-A-GLANCE

  • Sulfur is the third most abundant mineral in your body. Sulfur-containing amino acids increase your levels of glutathione and N-acetylcysteine (NAC), which play important roles in health and fitness
  • Glutathione metabolism influences the control of epigenetic mechanisms at several levels, including substrate availability, enzymatic activity for DNA methylation and the expression of microRNAs
  • NAC supplementation may be useful for the prevention of cardiovascular problems in older people by lowering oxidative stress and improving mitochondrial function
  • Glutathione deficiency can induce epigenetic changes in genes that regulate vitamin D metabolism in the liver, and research suggests glutathione supplementation could help reduce the risk of vitamin D deficiency in obese individuals
  • Glutathione and NAC also ameliorate exercise-induced stress and reduce muscle fatigue. Glutathione may also play a central role in chronic fatigue syndrome

As explained in “The Health Benefits of MSM,” sulfur is the third most abundant mineral in your body and plays important roles in a variety of bodily processes, including metabolism and detoxification, and for maintaining the proper shape and structure of proteins and enzymes.

Sulfur-containing amino acids increase your levels of glutathione and N-acetylcysteine (NAC), and these two play important roles in health and fitness.

Glutathione Basics

Glutathione comprises three amino acids: cysteine, glutamate and glycine. It’s commonly referred to as “the master antioxidant,” as it is your body’s most powerful antioxidant, and is found inside every cell in your body.

Antioxidants combat free radicals — highly reactive particles that bounce around the cell, damaging everything they touch. Most originate during the process of metabolism but they can also arise during exercise, and from exposure to toxins, irradiation and toxic metals.

Because free radicals are so destructive, cells have a network of defenses designed to neutralize them. This antioxidant network is composed of numerous components that include vitamins, minerals and special chemicals called thiols (glutathione and alpha-lipoic acid).

Glutathione differs from other antioxidants in that it is intracellular, and has the unique ability of maximizing the activity of all the other antioxidants, including (but not limited to) vitamins C and E, CoQ10 and alpha lipoic acid. It also removes toxins from your cells and protects you from the damaging effects of radiation, chemicals and environmental pollutants.

NAC Basics

NAC is a precursor to and rate-limiting nutrient for the formation of glutathione.1 Glutathione is poorly absorbed so, in many cases, it’s easier to raise your glutathione by taking NAC instead.

In emergency medicine, NAC is used as an antidote for acetaminophen toxicity resulting from an overdose.2 Mortality due to acetaminophen toxicity has been shown to be virtually eliminated when NAC is promptly administered.

It is believed the liver damage acetaminophen causes is largely due to the fact that it can deplete glutathione, which is secreted by your liver in response to toxic exposure.

On a side note, NAC supplementation can also help “pre-tox” your body when taken before alcohol, thereby minimizing the damage associated with alcohol consumption — a tidbit that may be useful to know in light of approaching New Year’s celebrations.

Taking NAC (at least 200 milligrams) 30 minutes before you drink can help lessen the alcohol’s toxic effects. Vitamin B6 may also help to lessen hangover symptoms.

While the most common use of NAC is for liver support, it’s also showing promise as a neuroprotectant.3 Scientists are currently investigating it as a treatment for Parkinson’s disease, which has been linked to glutathione deficiency in the substantia nigra, a region that houses dopamine neurons.4

Research looking at autopsied brains suggests Parkinson’s patients have barely detectable levels of glutathione in this brain region. Subsequent studies have found glutathione deficiency in the substantia nigra is common in a number of other neurodegenerative conditions as well, including Alzheimer’s disease.5

Another area where NAC shows particular promise is in the treatment of mental health disorders, including post-traumatic stress disorder,6 depression7 and substance use disorders.8 Dozens of additional health benefits are also reviewed in a November 29, 2019, SelfHacked article.9

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Glutathione Helps Regulate Epigenetic Disease Mechanisms

One factor that can help explain the wide-ranging benefits of NAC and glutathione is glutathione’s role in the regulation of epigenetic disease mechanisms.10 As noted in a November 2017 paper in Free Radical Biology and Medicine:11

“Epigenetics is a rapidly growing field that studies gene expression modifications not involving changes in the DNA sequence.

Histone H3, one of the basic proteins in the nucleosomes that make up chromatin, is S-glutathionylated in mammalian cells and tissues, making Gamma-L-glutamyl-L-cysteinylglycine, glutathione (GSH), a physiological antioxidant and second messenger in cells, a new post-translational modifier of the histone code that alters the structure of the nucleosome.

However, the role of GSH in the epigenetic mechanisms likely goes beyond a mere structural function. Evidence supports the hypothesis that there is a link between GSH metabolism and the control of epigenetic mechanisms at different levels (i.e., substrate availability, enzymatic activity for DNA methylation, changes in the expression of microRNAs, and participation in the histone code).”

The following graphic12 illustrates how glutathione influences pathological changes in gene expression.

glutathione influences pathological changes in gene expression

NAC Improves Cardiovascular and Mitochondrial Function

According to a 2018 study,13 NAC supplementation may be useful for the prevention of cardiovascular problems in older people. As you might expect, oxidative stress can over time induce metabolic and functional changes that speed cardiovascular aging and dysfunction, and your glutathione levels declines with age, putting you at greater risk.

In this study, aging mice received either NAC or a combination of NAC and glycine. After seven weeks, their cardiac function was assessed, showing those receiving NAC plus glycine had improved several parameters of their cardiovascular function, including:

  • Improved diastolic function
  • Increased peak early filling velocity
  • Reduced relaxation time
  • Reduced left atrial volume
  • Reduced left ventricle end diastolic pressure

NAC alone did not impart these cardiovascular benefits, although both groups had decreased levels of inflammatory mediators. The NAC and glycine combination also improved mitochondrial function and upregulated mitochondrial genes in the heart that are normally downregulated with age.

According to the authors, “Our data indicate that NAC+Gly supplementation can improve diastolic function in the old mouse and may have potential to prevent important morbidities for older people.”

Glutathione Deficiency Lowers Vitamin D Levels in the Obese

Other recent research14 published in Scientific Reports shows that glutathione deficiency can induce epigenetic changes in genes that regulate vitamin D metabolism in the liver. Emerging evidence also suggests glutathione metabolism plays a role in the epigenetic regulation of oxidation-reduction (redox) reactions, the authors note.

According to this paper,15 obesity has been correlated with low levels of glutathione and 25-hydroxyvitamin D3 — especially in Type 2 diabetics and the obese16 — and when obese mice were fed a glutathione-deficient diet, it downregulated vitamin D metabolism genes and vitamin D receptors in the liver. As a result, oxidative stress increased.

According to the authors, their findings suggest glutathione supplementation could help reduce the risk of vitamin D deficiency in obese individuals. Supplementation with L-cysteine, a rate-limiting precursor to glutathione, has also been shown to increase vitamin D levels and reduce oxidative stress, the paper notes, which supports the link between glutathione and vitamin D.

Glutathione and NAC Ameliorate Exercise-Induced Stress

As mentioned earlier, exercise is one of the ways through which free radical production increases and, with it, oxidative stress. Provided you get enough rest between bouts, this oxidative stress is actually part of what makes exercise so beneficial.

That said, as noted in a 2005 paper,17 “Effective regulation of the cellular balance between oxidation and antioxidation is important when considering cellular function and DNA integrity as well as the signal transduction of gene expression.” In other words, excessive exercise can cause more harm than good. As explained by the authors:18

Exercise enthusiasts and researchers have become interested in recent years to identify any means to help minimize the detrimental effects of oxidative stress that are commonly associated with intense and unaccustomed exercise. It is possible that a decrease in the amount of oxidative stress a cell is exposed to could increase health and performance …

To protect against the deleterious effects of ROS [reactive oxygen species], our bodies have a complex system of endogenous antioxidant protection in the form of enzymes such as superoxide dismutase, catalase, and glutathione peroxidase. Under normal, resting conditions reactive oxygen species are removed from the cell preventing any subsequent damage.

However, under more extreme conditions such as: 1) inadequate intake of foodstuffs containing the antioxidants, 2) excessive intake of pro-oxidants, 3) exposure to noxious chemicals or ultraviolet light, 4) injury/wounds, and/or 5) intense exercise, especially eccentric exercise, the body’s endogenous antioxidant system is not able to effectively remove excessive ROS production.

In situations such as the ones listed above in which the production of pro-oxidant molecules increase to a point where the antioxidant system cannot effectively remove them is when oxidative stress is known to occur.

Oxidative stress has been implicated in a number of diseases which include atherosclerosis, pulmonary fibrosis, cancer, Parkinson’s disease, multiple sclerosis, and aging. Research on oxidative stress during exercise has begun to indicate that regular training enhances the ability of these mechanisms to effective respond to the increase of oxidative product.”

Exercise Boosts Your Glutathione Level

The 2005 paper above goes on to explain how exercise affects your glutathione level, and thus your health, fitness and risk of disease. In short, when you engage in intense exercise, your blood level of glutathione significantly decreases while circulating levels of oxidized glutathione increases, indicating that it’s been used inside the muscle to quench free radicals produced during the exertion.19

Considering the importance of glutathione to counteract free radicals, effective regulation of glutathione levels when exercising is a significant concern. The good news is that the more you exercise, the higher your base levels of glutathione get.

This adaptation allows your body to effectively deal with the increase in free radicals that the exercise brings about. While exercise itself will boost your glutathione level over time, raising glutathione through supplementation is an oft-used strategy among athletes.

As mentioned, glutathione supplementation is ineffective due to its poor absorption, so NAC is generally considered a much better choice. According to the authors of the 2005 paper cited above:20

“In addition to the role glutathione and other thiols have on maintaining the cellular redox state, many studies have begun to explore if NAC supplementation can actually improve performance due to its ability to promote a more favorable cellular environment to achieve higher levels of performance …

One of the first studies to utilize NAC to determine its role in improving muscle performance was conducted by Reid and colleagues. They pretreated subjects with n-acetyl-cysteine infusion (150 mg/kg) or a 5% dextrose placebo while undergoing an extended fatiguing bout of electrical stimulation of the ankle dorsiflexors.

N-acetyl-cysteine was found to have no impact over the nonfatigued muscle, but a significantly increased force output of approximately 15% was found after 3 minutes of repetitive contractions which persisted throughout the 30-minute protocol. The authors concluded that NAC resulted in improved performance suggestive of oxidative stress having a causal role in the fatigue process.”

Other studies have also confirmed that NAC supplementation helps delay muscle fatigue during exercise, thereby improving endurance. In one study,21 NAC infusion increased the time to exhaustion by 26.3%.

NAC’s ability to reduce fatigue and improve cellular redox (oxidation reduction) also hints at its potential benefit for those struggling with chronic fatigue syndrome (CFS).

The Glutathione Depletion Theory of CFS

As explained by the U.S. Centers for Disease Control and Prevention, CFS, also known as myalgic encephalomyelitis or ME, is characterized by “overwhelming fatigue that is not improved by rest.”22 The fatigue is frequently such that it challenges your ability to perform even the most common of daily life tasks, such as showering or preparing a meal.

The role of glutathione in this condition is addressed in “A Simple Explanation of the Glutathione/Methylation Depletion Theory of ME/CFS”23 by the late Rich Van Konynenburg, Ph.D., developer of the methylation protocol used by many in the CFS community.24,25

According to Van Konynenburg, oxidative stress “is probably the best-proven biochemical aspect of chronic fatigue syndrome,” and in order for your oxidative stress to overwhelm your system, something must be placing excessive demands on your glutathione supply.

Several examples were already listed above, such as inadequate antioxidant and/or excessive pro-oxidant intake, toxic exposures and physical injuries. Long-term emotional stress can also be a factor. As noted in Van Konynenburg’s article:

“All people experience a variety of stressors all the time, and a healthy person’s body is able to keep up with the demands for glutathione by recycling used glutathione molecules and by making new ones as needed.

However, if a person’s body cannot keep up, either because of extra-high demands or inherited genetic polymorphisms that interfere with recycling or making glutathione, or both, the levels of glutathione in the cells can go too low …

One of the jobs that glutathione normally does is to protect your supply of vitamin B12 from reacting with toxins … When your glutathione level goes too low, your B12 becomes naked and vulnerable, and is hijacked by toxins.

Also, the levels of toxins rise in the body when there isn’t enough glutathione to take them out, so there are two unfortunate things that work together to sabotage your B12 when glutathione goes too low.”

The B12-Glutathione Connection

Vitamin B12 helps your body convert food into glucose for energy, and fatigue is one of the symptoms of low B12 levels.26 Interestingly, many with CFS have elevated B12 levels. Their bodies simply cannot use it properly, and one potential culprit is low glutathione.

“The best test to reveal this is a urine organic acids test that includes methylmalonic acid. It will be high if the B12 is being sidetracked, and this is commonly seen in people with CFS,” Van Konynenburg states, adding:27

“The most important job that B12 has in the body is to form methylcobalamin, which is one of the two active forms of B12. This form is needed by the enzyme methionine synthase, to do its job. An enzyme is a substance that catalyzes, or encourages, a certain biochemical reaction.

When there isn’t enough methylcobalamin, methionine synthase has to slow down its reaction. Its reaction lies at the junction of the methylation cycle and the folate cycle, so when this reaction slows down, it affects both these cycles …

The methylation cycle has some important jobs to do. First, it acts as a little factory to supply methyl (CH3) groups to a large number of reactions in the body. Some of these reactions make things like creatine, carnitine, coenzyme Q10, phosphatidylcholine, melatonin, and lots of other important substances for the body.

It is not a coincidence that these substances are found to be low in CFS … Not enough of them is being made because of the partial block in the methylation cycle.

The methylation cycle also supplies methyl groups to be attached to DNA molecules, and this helps to determine whether the blueprints in the DNA will be used to make certain proteins according to their patterns.

The ‘reading’ of DNA is referred to as ‘gene expression.’ Methyl groups prevent or ‘silence’ gene expression. Overexpression of genes has been observed in CFS patients, and I suspect this is at least partly due to lack of sufficient methylation to silence gene expression.”

The Basic Biochemical Mechanism of CFS

The methylation cycle also regulates your body’s use of sulfur, and the production of sulfur-containing substances, including glutathione. CFS patients often have abnormal levels of sulfur metabolites. Once you understand the interconnectedness of glutathione, B12 and the methylation cycle, it becomes easier to see how chronic CFS arises. As explained by Van Konynenburg:28

“When glutathione goes too low, the effect on vitamin B12 slows down the methylation cycle too much. The sulfur metabolites are then dumped into the transsulfuration pathway (which is connected to the methylation cycle) too much, are oxidized to form cystine, pass through hydrogen sulfide, and are eventually converted to thiosulfate and sulfate and are excreted in the urine.

This lowers the production of glutathione, which requires cysteine rather than cystine, and now there is a vicious circle mechanism that preserves this malfunction and keeps you sick … That’s the basic biochemical mechanism of CFS … everything else flows from this …

Here’s how I believe the fatigue occurs: The cells have little powerplants in them, called mitochondria. Their job is to use food as fuel to produce ATP (adenosine triphosphate). ATP acts as a source of energy to drive a very large number of reactions in the cells.

For examples, it drives the contraction of the muscle fibers, and it provides the energy to send nerve impulses. It also supplies the energy to make stomach acid and digestive enzymes to digest our food, and many, many other things.

When glutathione goes too low in the muscle cells, the levels of oxidizing free radicals rise, and these react with parts of the ‘machinery’ in the little powerplants, lowering their output of ATP.

So the muscle cells then experience an energy crisis, and that’s what causes the fatigue. Over time, because of the lack of enough glutathione, more problems accumulate in the mitochondria, including toxins, viral DNA, and mineral imbalances.”

All of these factors will ultimately decimate your immune function as well, allowing pathogenic bacteria, viruses and fungi to take over. CFS patients will frequently have several infections ongoing at the same time. Low glutathione also impedes your body’s natural detoxification pathways, allowing toxicity to build over time, thereby causing ever-increasing dysfunction.

The Answer for CFS

So, how do you turn this chain of events around? As noted in Van Konynenburg’s article:29

“The main key to turning this process around is to help the methionine synthase enzyme to operate more normally, so that the partial block in the methylation cycle and the folate cycle are lifted, and glutathione is brought back up to normal. That is what the simplified treatment approach is designed to do, and so far, the evidence is that it does do these things in most people who have CFS.

I recommend that people with CFS have the Vitamin Diagnostics methylation pathways panel run to find out if they do in fact have a partial methylation cycle block and glutathione depletion before deciding, with their doctors, whether to try this treatment.

This also provides a baseline so that progress can be judged later on by repeating it every few months during the treatment. Symptoms may not be a good guide to judge progress during treatment, because detoxing and die-off can make the symptoms worse, while in fact they are exactly what is needed to move the person toward recovery.”

An outline of Van Konynenburg’s simplified methylation treatment plan for CFS can be found in HealthRising.org.30 At the core of this treatment is the use of specific supplements, including folate, B12, a multivitamin, SAMe and phosphatidyl serine.

In his protocol, he explains the theory behind the use of each of these supplements, how they impact the methylation cycle, and their interactions with other supplements.

My take-home message here is that glutathione and NAC supplementation may not always be the ideal way to go. People with CFS may be better supported by a customized assessment by an experienced clinician that may also include methyl folate and methyl vitamin B12.

General Dosing and Safety Guidelines for NAC

For many others, however, NAC can be safely used to boost glutathione levels. For more information about how NAC can benefit your health, see “The Many Benefits of NAC.” It’s widely available as an oral dietary supplement and is relatively inexpensive. Unfortunately, like glutathione, NAC is poorly absorbed when taken orally, although it’s better than glutathione.

According to some studies,31,32 NAC’s oral bioavailability may range between 4% and 10%, which is why the recommended dosage can go as high as 1,800 milligrams (mg) per day. Its half-life is also in the neighborhood of two hours, which is why most study subjects take it two or three times a day.

No maximum safe dose has yet been determined, but as a general rule, it’s well-tolerated, although some do experience gastrointestinal side effects such as nausea, diarrhea or constipation. Should this occur, reduce your dosage. It’s also best taken in combination with food, to reduce the likelihood of gastrointestinal effects.

Also keep in mind that since NAC boosts glutathione, which is a powerful detox agent, you may experience debilitating detox symptoms if you start with too high a dose. To avoid this, start low, with say 400 to 600 mg once a day, and work your way up.

Also, if you are currently taking an antidepressant or undergoing cancer treatment, be sure to discuss the use of NAC with your physician, as it may interact with some antidepressants and chemotherapy.

 Sources and References

Medicinal Mushrooms Cut Herpes Suffering Time in Half

© 26th November 2019 GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here www.greenmedinfo.com/greenmed/newsletter
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half

The herpes virus afflicts millions of people worldwide, causing painful blister-like sores that are often embarrassing. There is no known cure, and medications have a long list of potential side effects and a “take it forever” prescription. Did you know that there is a clinically proven, natural way to provide relief that is growing right under your feet?

Mushrooms, both wild and cultivated, have been prized for their medicinal value for more than 2,000 years. A staple of Traditional Chinese Medicine (TCM), Ganoderma lucidum or lingzhi mushroom, commonly called reishi, are among the rarest and most prized of therapeutic, edible fungi.

Deemed by ancient healers as the “mushroom of immortality,” reishis are large, dark mushrooms with a shiny, slick surface and “woody” texture, which is unsurprising, considering that they grow on old, hardwood trees. In order to meet culinary and medicinal demands for this valued mushroom, reishis are now actively cultivated in different varieties, using wood chips and logs as growing mediums.

One potential benefit of supplementing with this superfood is its proven ability to ease the painful symptoms from recurrent herpes simplex viral infections.

Herpes: A Global Epidemic

According to the World Health Organization, an estimated 3.7 billion people (nearly 70% of adults worldwide under age 50) are infected with herpes simplex virus type 1 (HSV-1).[1] Often referred to as “oral herpes,” this type generally presents with lesions known as “cold sores” on or around the mouth. HSV-1 is mainly transmitted via oral-to-oral contact but can also cause genital herpes via oral-to-genital contact.

An estimated 417 million people from this same group (around 11% of adults under 50 worldwide) have HSV type 2 infections (HSV-2), or genital herpes.[2] Both types of herpes are considered lifelong infections with no known cure.

While most herpes infections are asymptomatic, for some sufferers, outbreaks are severe and can recur frequently. Symptoms include painful blisters at the site of infection, open ulcerations that burn and weep, and chronic itching. Non-physical symptoms can be acute, including shame and a desire for physical isolation due to social stigma surrounding infection.

Mushrooms Speed Relief of Herpes Symptoms

With no known cures and few effective treatments, scientists are focused on finding ways to help sufferers manage this often-debilitating condition more effectively. It was to this end that researchers at the Toyodo Hijikata Clinic and Kansai Medical University in Osaka, Japan, conducted a clinical experiment on medicinal mushrooms’ ability to improve recovery time for patients suffering from outbreaks due to HSV-2.

Published in the Journal of Alternative and Complementary Medicinethe paper details the attempt to reduce the amount of time needed for patients afflicted by genital herpes outbreaks to return to an asymptomatic state using an herbal mixture comprised primarily of reishi-type mushrooms.

A total of 28 adults participated in this clinical study. These individuals had experienced recurrent herpes outbreaks for more than one year and had received standard outpatient care at other medical facilities without improvement.

The treatment mixture, a combination of two, powdered reishi-type mushrooms (Ganoderma lucidum, Elfuinga applanata) and other traditional herbal remedies such as water chestnut and tropical almond, was administered to test subjects, while the control group received no treatment.

According to published results, the difference was dramatic: the mushroom and herb mixture provided “…fast, effective relief from symptoms of recurrent herpes (genitalis and labialis).” Herpes genitalis sufferers experienced a decrease in symptomatic time of more than 50% compared to the control group, with an average 4.9 days to recovery from pain and associated symptoms, while the group receiving no treatment required 10.9 days before relief was experienced.

Similarly, the time required to obtain relief from herpes labialis was nearly eight days without treatment but only four days when patients received the herbal supplement.

Effective Relief From Herpes Pain

A similar study provides reliable confirmation of the power of mushrooms to inhibit the pain associated with herpes outbreaks. Herpes zoster is another type of herpetic infection caused by reactivation of the varicella-zoster virus that causes chickenpox.

Also called “shingles,” herpes zoster is characterized by ulcerative lesions on the skin forming a painful rash-type cluster of blisters that can be slow to heal. Current conventional treatment protocols include oral antiviral medications, as well as pain medications to provide relief from these outbreaks.

The 2005 study, a pilot clinical trial, was published in the American Journal of Chinese Medicine.[3] Researchers provided a hot water extract of herbs containing Ganoderma lucidum, aka reishi mushroom, to five patients suffering from shingles. According to published results, pain relief was experienced within a few days of intake, with near-complete pain relief by day 10 of administration of the herbal extract.

Relief was experienced by patients of all ages (from 17 to 74 years) and in all outbreak locations (head, legs and lower body). Patients responded quickly to treatment and after more than one year of follow-up examinations, no patient had developed post-herpetic neuralgia, a lingering pain that is the most common after-effect of shingles.

Are Mushrooms a Prescription for Long Life?

Reishi mushrooms have been widely studied in modern medical research, with many of their traditional therapeutic powers confirmed.

Known for their ability to boost the circulatory and immune systems, people supplement with reishi mushrooms for health conditions such as high blood pressure and high cholesterol, and to improve cardiovascular health, among other documented benefits. Some of the properties attributed to reishis include their ability to:

Mushrooms as Nutritional Medicine

Mushrooms are often considered a vegetable but are in fact a type of edible fungus. Rich in seleniumniacinpotassiumvitamins D and B3, as well as copper and iron, mushrooms are potent antioxidants that activate the immune system, eradicate dangerous free radicals and ensure proper functioning of nerves and muscles.

While eating reishi mushrooms is less common due to their tough, woody texture and bitter taste, this healing powerhouse is widely available as a tea and in both liquid and powdered extract formulas.

Red reishis have the longest history of medicinal use and have been shown to be effective in the treatment of a wide range of health conditions. Unlike other mushrooms, only the reishi (Lingzhi) has triterpenes (ganoderic acid), an important compound that gives them their bitter taste and is widely believed to be responsible for reishi’s amazing pharmacological effects.

Finally, mushrooms have a beneficial effect on the all-important microbiome, contributing a prebiotic effect by encouraging proliferation of healthy gut bacteria, resulting in better digestion, anti-aging effects and improved metabolic processes, including potential weight loss.[4] This effect is attributed to the cobweb-like mycelium that make up the mushrooms’ structure, and connects mushroom clusters underground via a network of intelligent signaling pathways.

Explore the many healing effects of medicinal mushrooms and take advantage of Mother Nature’s infinite healing intelligence. GreenMedInfo has an in-depth database of nutritional-medical research. Find out more by exploring the 138 abstracts reishi mushrooms and their miraculous healing potential.


References

[1] https://www.who.int/news-room/fact-sheets/detail/herpes-simplex-virus

[2] IBID

[3] Am J Chin Med. 2005;33(4):517-23.

[4] https://www.nature.com/articles/nrgastro.2015.137

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

New Insights on Gut Permeability and Depression

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Common antibiotic could lead to fatal heart issues

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antibiotic

(NaturalHealth365) Antibiotics are a popular class of drugs that the U.S. Centers for Disease Control and Prevention (CDC) estimate are frequently over-prescribed. In fact, the CDC has previously suggested that as many as 1 in 3 antibiotic prescriptions are unnecessary!

Used to kill infections, antibiotics can also wreak havoc on your gut health and immune system. And along with the physicians incorrectly prescribing them and individuals incorrectly taking them, antibiotics are giving rise to the dangerous public health crisis of antibiotic resistance, aka “superbugs.”  To make matters worse, data indicates that a certain type of antibiotic sold as, Zithromax poses serious heart risks to consumers.

Heart attack warning: Zithromax antibiotic could be a deadly choice

Zithromax is an antibiotic typically prescribed for infections like bronchitis, ear infections, and pneumonia.  Sometimes called azithromycin, Zmax, or “Z-Pack”, many doctors and patients prefer it because it can be taken for fewer days than other common antibiotics like amoxicillin. Compared to the typical 10-day course, a full course of Zithromax is only five days.

However, Zithromax is twice as expensive as generic amoxicillin and can cost as much as a few bucks per pill – which likely explains why pharmaceutical companies love it so much (sales for the drug topped $464 million in 2011 in the United States alone).

But data from a 2012 study out of Vanderbilt University determined that people who use Zithromax have an increased risk of sudden deadly heart issues. Researchers looked at millions of antibiotic prescriptions given to well over half a million Medicaid patients between the years of 1992 and 2006.

They discovered that 29 heart-related deaths occurred among people taking Zithromax during the short five-day course.

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While rare, these heart-related deaths were enough to show that certain individuals taking Z-Pack drugs may be twice as likely to die while taking the drug compared to similar individuals taking other kinds of antibiotics (or taking none at all).  The proposed reason is that Z-Pack drugs may lead to dysfunctional electrical activity and ultimately lead to fatal heart rhythms.

This data has been corroborated by other research, including a follow-up paper published in May 2012 in the prestigious New England Journal of Medicine.

Today, the U.S. Food and Drug Administration cautions medical providers to avoid giving Zithromax to patients with known cardiovacular risk factors, including prolonged QT intervals, potassium or magnesium deficiencies, bradycardia (slow heart rate), or people already taing drugs to treat abnormal heart rhythms.

How to avoid the need for antibiotics and reduce your risk of infections

Let’s face it: antibiotics are a risky class of drugs and are medically unnecessary at least 30% of the time.

So, to help yourself stay healthy throughout the year and help you avoid both bacterial infections and antibiotics …

  • Make sure you’re getting enough vitamin C and vitamin D through foods like leafy greens, citrus fruits, fatty fish and eggs (you can also back up your health with high quality supplements).
  • Cut out heavily processed foods: Especially simple sugars, these foods are main drivers behind the rise of chronic disease and can make you sick, fat, and more prone to infections.
  • Commit to good quality sleep! Not getting enough sleep damages your immune system. It also promotes weight gain and higher levels of stress.

Sources for this article include:

NHS.uk
Mayoclinic.org
CBSnews.com
NEJM.org
Medicalnewstoday.com
Yahoo.com
CDC.gov
FDA.gov

The Little Known Miracle of Life: Fulvic acid

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Posted on: Thursday, November 7th 2019 at 12:30 pm

In the beginning, the earth was blessed with rich, fertile soil and lush vegetation. The soil was teaming with microbes — bacteria, fungi, and protozoa, to name a few. In the perfect cycle of life, microbes in the soil break down dead plant material and create substances and nutrients that nourish plants. When humans eat these plants, we enjoy the nutrients that they provide

The microbes in the soil make the hidden treasure called fulvic acid, the miracle of life. Fulvic acid is not a vitamin or a mineral and science cannot synthesize this substance in a laboratory. Our bodies require it for optimal health, but, we no longer get fulvic acid in adequate amounts from our food.

While the scientific research is growing in support of fulvic acid, there are less than 1,750 studies on PubMed.gov. One needs to dig around to find fulvic studies related to human benefits, but information and clinical evidence exists. This is not “just another supplement” but a powerful, life-giving substance that is quietly disappearing from our food and this is taking a toll on human health.

Fulvic acid has been reported to rejuvenate health and bring a multitude of benefits that are unmatched by any other natural substance.

Fulvic acid (FA) has been used for 3,000 years as Shilajit in Indian medicine.

Carrasco-Gallardo stated, “It is likely that the curative properties attributable to shilajit are provided by the significant levels of fulvic acids that shilajit contains, considering that fulvic acid is known by its strong antioxidant actions.” [v]

Historically, it was believed that fulvic acid/Shilajit had immune-modulating, antioxidant, diuretic, antihypertensive, and hypoglycemic benefits. [Winker][Trivadi] FA was used in diabetes, and to support the urinary, immune, digestive, cardiac, and nervous systems. [xxiv][i][ii][viii]

In Ayurveda literature it is called “rasayana” or rejuvenator, enhancing the quality of life. [xxxviii][xv]

Benefits

Fulvic acids can be found in compost or peat, lignite (brown coal which gives inferior fulvic acid) or ancient humic deposits that come from deep within the earth. Unlike other deposits formed over time deep below the earth’s surface, like coal, oil and natural gas, humic deposits are safe, providing powerful compounds that provide an impressive number of benefits for plants, humans and animals.

  • enhances the body’s absorption of vitamins and minerals [xxxix]
  • anti-inflammatory effects [iv][x][xiv][xxxvii][xxxiii]
  • anti-allergy [xl]
  • improves many aspects of eczema [xiv]
  • speeds skin healing [xxix][xiv][xxxvii]
  • enhances healing of wounds infected with drug-resistant pathogens [xliv][xlii]
  • protects against free radical damage as an antioxidant [iv][xxxiv][xxv]
  • anti-aging benefits [v]
  • improves gut flora and gut health [xxxix]
  • anti-diarrheal effects in animals and humans [xxvi]
  • improves energy levels [xxiv]
  • reduces oxidative stress [xxxix]
  • useful in treatment of osteoarthritis patients [xix]
  • shows antiviral activity, interfering with a virus’ ability to attach to a host cell, penetrate the host cell, and reproduce itself [xxii][xxviii]
  • displays antimicrobial activity [xxxvi]
  • displays antifungal activity [xiii][xxxii]
  • effective for the management of oral biofilm infections [xxxiii]
  • anti-aging effect on the skin, increasing fibroblast viability and reducing collagen degradation [xxi]
  • neuroprotective, improves memory and brain function [v][ix][xvi]
  • supports the immune system [xxxix]
  • stimulates metabolism [vi]
  • cleanses toxins and heavy metals from the body [xviii][vii][xxiii]
  • shows immunomodulatory activity [xxxi]
  • modulates homocysteine and pro-inflammatory mediators linked to atherosclerosis [xii]
  • promotes ulcer healing [xv][xxxi][xli]

Science cannot create fulvic acid

Fulvic acid offers a seemingly endless spectrum of benefits for human and animal health that would make any pharmaceutical company nervous. Fulvic acid cannot be made by man because it involves photosynthesis and humification. The process that creates fulvic acid requires nature’s recyclers, microorganisms, working in fertile, rich soil over a long period of time. Microbes decompose organic material (manure, compost, decaying plant material), in the soil to create nutrients for the plant including trace minerals, carbon, hydrogen, oxygen, nitrogen, phosphorus, and potassium. Microbes make the minerals in the soil into a useful form for plants and over time the microbes help create an amazing substance called humus (hyoo-muh s).

“Essentially, All Life Depends Upon The Soil … There Can Be No Life Without Soil And No Soil Without Life”

~ Charles E. Kellogg, head of the Soil Survey in the United States Department of Agriculture (USDA) for 37 years (1934-1971)

We never had to worry about getting enough fulvic acid, it simply existed in our soil and in our food, since time began. Fertile soil, and the microbial life within it, is a highly valuable natural resource that is critical for food security and for human health. Fertile soil is teaming with microbial life (it is interesting to note that there are more bacteria in two spoonfuls of rich, fertile soil than there are humans on planet earth). Sustainable farming practices that add compost and organic compounds to the soil help create a robust microbial community. Microbes are required for the cycle of life. They work to break down plant and animal matter, and over hundreds and thousands of years, fulvic acid is one of the end products of decomposition.

Common agricultural practices cause the loss of fulvic acid in food and the progressive deterioration of human health

Over the past 50 to 100 years, farming practices that sustained humans for thousands of years have drastically changed. Chemical fertilizers, herbicides and pesticides were created to increase crop yield, kill insects and control weeds. Modern agricultural practices increase the amount of food produced but the toll this has taken on soil microbes, plant nutrients and human and animal health is underappreciated.

While attempting to kill the pests and weeds and bolster plant production, the chemicals used in agriculture have inadvertently attacked friendly troops in the soil jungle.

The price of growing food this way is dramatically altering the natural recycling process required in nature, and the downstream effects on human health are mounting.

Fulvic acid may seem like “just another nutrient” that is declining in food, but it is actually the most important health-building compound because it is nature’s intended vehicle for transporting minerals and other nutrients into living cells.

Fulvic acid is nature’s answer to depleted food and too many toxins

Fulvic acid and humic acid are the key substances found in humus, the end result of the humification process where microbes in the soil break down once living matter, usually plants. It is believed that most of the health benefits attributed to Shilajit and humic substances are primarily due to the presence of fulvic acid. [v]

Fulvic acid is a very small molecule of low molecular weight. It is smaller than humic acid and penetrates the cell membrane and even the mitochondria. [v] Because fulvic acid bonds easily to nutrients like vitamins and minerals, it efficiently delivers nutrients where they are needed. Without fulvic acid our bodies’ ability to absorb nutrients (from food or supplementation) is diminished. [xxiv]

Fulvic acid’s small molecular weight coupled with the fact that it is water soluble at all pH levels, makes it superior for working in the body to:

  • deliver nutrients
  • bring antioxidant benefits
  • remove cellular waste products and toxins [xliii]

“You can trace every sickness, every disease and every ailment to a mineral deficiency.”

~Dr. Linus Pauling, awarded two Nobel Prizes

It is well known that minerals are required for a range of biochemical processes, but mineral deficiencies are epidemic. Our food lacks the vitamin and mineral content that it should have and most supplements do not absorb well enough to correct mineral deficiencies. The fulvic acid complex contains bioavailable minerals and trace elements that are desperately needed to combat widespread mineral deficiency in humans.

Fulvic acid is nature’s answer to the problem that man has created with over-farming and the production of processed foods.

Fulvic acid is a magical vehicle with 60 seats

The main components of fulvic acid are carbon, hydrogen and oxygen. These molecules in fulvic acid easily bond to other molecules and transport them through the body. It can possess over 70 trace elements, electrolytes, polyphenols, flavonoids, and essential amino acids.

Naturopathic physician, Dr. Daniel Nuzum, has been studying fulvic acid since 1998. He has used fulvic acid supplements with thousands of patients, and he researches and teaches extensively about fulvic acid. Very few doctors can make this claim, and have little to no experience with fulvic acid. Dr. Nuzum is an expert and he is able to communicate a difficult concept in a way that is easy to understand. “Fulvic acts like the FedEx truck and the garbage truck,” Dr. Nuzum explained. “It delivers nutrition into the cell and carries the trash (toxins & waste) out too!”

Fulvic acid has 60 receptor sites and because it is a carbon-based compound, it bonds easily to nutrients. Dr. Nuzum likens fulvic acid to a 60-passenger bus carrying nutrients in each of the 60 seats. The fulvic acid bus travels along to cells needing a nutrient package delivered. When it drops off the nutrient package, a seat is empty on the fulvic acid bus, so it picks up cellular waste and toxins, like the garbage man, and removes them from your system.

The missing puzzle piece

Many people are feeling the effects of low nutrient absorption, even in the presence of a good diet with regular intake of supplemental vitamins and minerals. This information about fulvic acid is the missing puzzle piece for many people seeking health. Whether you are fighting an infection, rebuilding health, or desire anti-aging strategies, add fulvic acid daily to help your body absorb and use needed nutrients. Take advantage of this powerful electrolyte and antioxidant.

Increase cellular voltage to increase health and energy

Fulvic acid has highly active carbon, hydrogen, molecular oxygen (available oxygen) and enables better electrolyte balance. It recharges cells allowing them to carry an electrical charge longer than normal and survive longer as a cell.

Your body must get enough electrons to keep cells at a healthy, healing voltage. While proper nutrition is a critical piece, it is not enough without voltage. This is where fulvic acid comes in to help. Fulvic acid brings molecular oxygen into the body, increasing the oxygen concentration.

CareyLyn Carter, biochemist and researcher said in an interview, “Fulvic acid molecules act like mini-batteries, going around and charging everything that it comes in contact with. It raises the voltage. When our cell’s membranes are fully charged, nutrients can get inside the cell more easily. When nutrients are inside cells they are available for biochemical processes that support our wellness.”

A closer look at fulvic acid for skin conditions, cancer and brain health

Fulvic acid improves skin conditions

Fulvic acid has anti-inflammatory properties.

A randomized, double blind, controlled study showed that fulvic acid significantly improves inflammatory skin conditions, like eczema with topical use, twice daily. It has been shown to be a safe and effective treatment for skin infections, and would be useful for humans and animals. [xiv]

It was found that fulvic acid reduces the pH of the skin, relieves the itch and improves the appearance of the skin rash. [xiv] FA relieves inflammatory skin conditions. [xxxvii]

Fulvic acid has antimicrobial properties and is a safe and effective topical treatment for skin infections. [xxxvi] Previously studies were cited supporting the use of fulvic acid and humic substances for wounds, rashes and fungal infections.

Fulvic acid has anti-cancer actions

Fulvic acid and the humic compounds are potential cancer chemopreventive agents [xxvii] and have been shown to induce cancer cell apoptosis. [xx]

Fulvic acid and humic substances have actions that combat certain cancer risk factors:

  • free radicals (fulvic acid acts as an antioxidant) [v][xliii][xxx]
  • toxins and heavy metals (fulvic acid bonds to and removes toxins and heavy metals) [xviii][vii][xxiii]
  • UV Radiation (fulvic acid is a photoprotective agent) [xxiv]
  • diabetes (humic substances showed hypoglycemic effects in animal studies) [xxxv]
  • inflammation (Winkler and Ghosh stated in a 2018 review study “there is substantial evidence to pursue FvA (fulvic acid) research in preventing chronic inflammatory diseases, including diabetes.”) [xxxix]

Huang showed that fulvic acid suppresses resistin. High levels of serum resistin are associated with several types of cancer and is thought to play a role in the development of colorectal cancer (CRC) by initiating the adhesion of colorectal cancer cells to the endothelium. FA inhibits the adhesion of CRC activated by resistin.[xvii]

Fulvic acid is neuroprotective and gives brain benefits

The Journal of Alzheimer’s Disease, published a study in 2011 that concluded, fulvic acid “has several nutraceutical properties with potential activity to protect cognitive impairment.” Researchers showed evidence that fulvic acid inhibited the formation of intracellular tangles of tau protein, seen in Alzheimer’s disease. [ix]

How to supplement with fulvic acid

Natural sources of fulvic acid

As discussed, conventional food production methods are destroying microbes in the soil, therefore it is imperative to eat the highest quality, organically grown food possible to increase the fulvic acid content and nutrient content of the food.

Organic vegetables

It is possible to get fulvic acid from plants, provided that they have been grown organically, in fertile soil, rich in humic substances. As you know from the earlier discussion on current agricultural practices, this is very difficult to find these days so most people benefit from taking fulvic acid as a supplement.

The best organic vegetables, in terms of fulvic acid, are the root vegetables like radishes, carrots and beets, but there is no way to know for sure that you are getting adequate fulvic acid from your diet.

Organic unsulphured blackstrap molasses from sugar cane

Another source of fulvic acid is organic unsulphured blackstrap molasses from sugar cane. This sweetener provides a good source of minerals and fulvic acid to aid in mineral absorption.

Fulvic acid supplementation

If you are taking any medication, please consult with your healthcare provider for contraindications. While fulvic acid is safe, there just are not enough studies on using fulvic acid with medication.

Take fulvic acid daily as part of your health rejuvenation regimen.

As fulvic acid supplements are being added to the market in a variety of forms, the consumer must be aware that not all fulvic acid supplements are equally safe. Fulvic acid is available in liquid preparations or powder supplements and capsules. It is believed that liquid forms are more bioavailable.

Here are a few things to consider when looking for a fulvic acid supplement:

  • Source. It is important to know that the fulvic acid was not obtained from brown coal (lignite) or deposits from a source contaminated with heavy metals like aluminumleadmercury and arsenic. Look for a product sourced from high quality humic shale.
  • Extraction. Look for fulvic acid extracted with pure, distilled water (not tap water) and no harsh solvents.
  • Water. Tap water containing chlorine and fluoride must never mix with fulvic acid or any of nature’s nutrients as harmful compounds can form. Find out if your fulvic acid provider uses tap water in their supplement preparation.
  • Potency. Will the supplier provide lab-verified data about their potency.
  • Preservative-free, ideally.
  • Glass packaging. Using any type of plastic in the extraction or bottling of fulvic acid is dangerous because the fulvic acid breaks plastic down. Plastic is a petroleum-based substance and will contaminate fulvic acid solutions.

Fulvic acid is a natural, water soluble substance that can be combined with liquids for oral consumption and it can be used topically. Follow directions from the manufacturer of the product you choose, and consider different options for use:

  • Combine fulvic acid with other plant compounds, like spirulina in water, to enhance the benefits.
  • Add fulvic acid to a smoothie or antioxidant superfood supplement drink.
  • Take fulvic acid with herbs, medicinal mushrooms or essential oils suitable for internal consumption.
  • Topically, use fulvic acid in a natural healing salve recipe including plant extracts known to support the skin’s healing.

Should you add fulvic acid to your daily health regimen?

The choice is yours. I believe that we need to supplement with fulvic acid now in order to harness the ability to get more nutrient absorption, increased detoxification, and increased electrical potential.

This may be the missing puzzle piece and help explain the dramatic increase in chronic disease that people of all ages are experiencing. The information on fulvic acid resonated with me the first time I began hearing about it. When that happens, I cannot keep silent – for who knows whether you and I have come to this information for such a time as this.

Originally published: 2019-11-06

Article updated: 2019-11-07

The Curious Bidirectional Link Between Gut Health and Sleep


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2019/11/14/sleep-and-gut-health.aspx

Analysis by Dr. Joseph MercolaFact Checked
sleep and gut health

STORY AT-A-GLANCE

  • Mounting research suggests your gut microbiome helps regulate not only your mood but also your sleep cycle through what’s known as the gut-brain axis — a bidirectional communication “highway” that links your central and enteric nervous systems
  • Your gut microbiota affect brain function through the immunoregulatory pathway, the neuroendocrine pathway and the vagus nerve pathway, all three of which have this bidirectional flow
  • Research shows the microbiota in your gut are under circadian control, which means disruptions in sleep can affect the composition and health of your microbiome, which can have significant impact on your overall health
  • The microbes in your gut can also affect the actual quality of your sleep. Total microbiome diversity is positively correlated with increased sleep efficiency and total sleep time
  • Recent research shows the composition of your gut microbiome, the quality and quantity of your sleep, your immune function and cognition are all connected

Sleep plays an integral role in your immune function, and one of the surprising mechanisms behind this link has to do with how sleep impacts your gut microbiome. Two recent studies shed light on this connection between sleep and your gut health.

The first, published in the December 2018 issue of Frontiers in Psychiatry,1 focused on the microbiome’s role in insomnia and depression. As noted by the authors:

“Numerous studies have suggested that the incidence of insomnia and depressive disorder are linked to biological rhythms, immune function, and nutrient metabolism, but the exact mechanism is not yet clear.

There is considerable evidence showing that the gut microbiome not only affects the digestive, metabolic, and immune functions of the host but also regulates host sleep and mental states through the microbiome-gut-brain axis.

Preliminary evidence indicates that microorganisms and circadian genes can interact with each other. The characteristics of the gastrointestinal microbiome and metabolism are related to the host’s sleep and circadian rhythm.”

Your Gut Microbiome’s Role in Insomnia and Depression

Previous studies have shown your gut microbiome can play a significant role in depression and anxiety, and that your diet — which can effectively alter the bacterial composition of your gut — can raise or lower your risk of these mood disorders.

As noted in the Frontiers in Psychiatry study,2 mounting research suggests your gut microbiome helps regulate not only your mood but also your sleep cycle through what’s known as the gut-brain axis — a bidirectional communication “highway” that links your central and enteric nervous systems.3

According to the authors of this paper, your gut microbiota affect brain function through three different pathways, all of which have this bidirectional flow:4

1.The immunoregulatory pathway — Here, gut bacteria influence brain function via interaction with immune cells that regulate your levels of cytokines, cytokinetic reaction factor and prostaglandin E2.

2.The neuroendocrine pathway — With more than 20 types of enteroendocrine cells, your intestine is the largest endocrine organ in your body. As explained by the authors,5 “The gut microbiome may affect the hypothalamic-pituitary-adrenal (HPA) axis and the central nervous system (CNS) by regulating the secretion of neurotransmitters such as cortisol, tryptophan and serotonin (5-HT).”

3.The vagus nerve pathway — Your enteric nervous system also plays an important role in the vagus nerve pathway. Here, gut microbiota can exert influence via sensory neurons in your intestinal myenteric plexus.

These intestinal neurons have synaptic connections to motor neurons in the intestine that help regulate hormone secretion in the gut and intestinal motility. Synaptic connections also exist between the intestinal nervous system and the vagus nerve, which connects your brain and intestine.

The authors note that neurotoxic metabolites produced by various gut microbiota can also enter into your CNS via your vagus nerve, “thereby affecting brain function, stress responses and sleep structure.”

As mentioned, the information flow through these three pathways is bidirectional, so your CNS can also regulate the composition of your gut microbiome through these pathways.

As one example, through its ability to alter the function of epithelial cells in your intestine, the HPA axis can affect the bacteria’s living environment, and in so doing, influence the composition of your gut microbiome.6

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Circadian Genes Affect Your Gut Microbiome

In 2017, the Nobel Prize in Physiology or Medicine went to three biologists for their discovery of master genes that control your body’s circadian rhythms. Your body contains not just one biological clock, but a vast array of clocks that regulate everything from metabolism to psychological functioning.

While the master clock in your brain synchronizes your bodily functions to match the 24-hour light and dark cycle, each and every organ, indeed each cell, has its own biological clock.

Half of your genes are also under circadian control, turning on and off in cyclical waves. As you might expect, the microbiota in your gut are also under circadian control, which means disruptions in sleep can affect the composition and health of your microbiome as well. As reported in Frontiers in Psychiatry:7

“Evidence suggests that Clostridiales, Lactobacillales, and Bacteroidales, which account for ~60% of the microbiota, show significant diurnal fluctuations that result in time-of-day-specific taxonomic configurations.

Liang et al. found that the two primary components of the mammalian intestinal microbiota, Bacteroidetes, and Firmicutes, showed cyclical changes in abundance from day to night that are related not only to rhythmic food intake and dietary structure but also to the biological clock and gender of the host.

Recent studies showed that circadian clock misalignment, sleep deprivation, and shift experience changes circadian clock gene expression and microbial community structure.

Interfering with the sleep patterns of mice can also change the structure and diversity of the intestinal microbiota. These findings suggest that circadian genes might affect the intestinal microbiota.”

So, to summarize the findings of this Frontiers in Psychiatry, there’s a bidirectional connection between your gut microbiome, your sleep and your risk of depression, and endocrine hormones and clock genes play important roles in these processes.

Microbiome Diversity Linked to Sleep Quality

The second study8,9 addressing the curious link between your gut health and sleep was published in PLOS ONE in 2019. Here, the researchers investigated how the microbes in your gut affect the actual quality of your sleep — which we already know can have far-reaching effects on your general health.

Poor sleep and/or lack of sleep has been linked to a wide variety of ailments and health conditions, ranging from poor cognitive performance and neurological dysfunction to an increased risk for Type 2 diabetes,10 heart disease,11 cancer12 and Alzheimer’s disease.13

On the other hand, high-quality sleep is associated with improved health, cognition and increased creativity, as discussed in “Using Sleep as a Tool for Creativity.”

Using advanced sleep measuring devices, the researchers were able to measure the quality of participants’ sleep, which was then compared to the composition of their gut microbiome to see if a correlation could be made. As reported by the authors:14

“We found that total microbiome diversity was positively correlated with increased sleep efficiency and total sleep time, and was negatively correlated with wake after sleep onset. We found positive correlations between total microbiome diversity and interleukin-6, a cytokine previously noted for its effects on sleep.

Analysis of microbiome composition revealed that within phyla richness of Bacteroidetes and Firmicutes were positively correlated with sleep efficiency, interleukin-6 concentrations and abstract thinking.

Finally, we found that several taxa (LachnospiraceaeCorynebacterium, and Blautia) were negatively correlated with sleep measures. Our findings initiate linkages between gut microbiome composition, sleep physiology, the immune system and cognition. They may lead to mechanisms to improve sleep through the manipulation of the gut microbiome.”

The Role of Cytokines

As mentioned at the beginning, sleep is known to influence your immune function, and cytokines, produced in response to an antigen, are multifunctional chemical messengers that help regulate your innate and adaptive immune systems.15

Interestingly, cytokines also appear to act as a “critical interface between sleep physiology and gut microbiome composition,” according to this study. As explained by the authors:16

“The acute phase pathway cytokines IL-1β and IL-6 in particular are strongly associated with sleep physiology. IL-1β is a major somnogenic factor. IL-1β administration in human and non-human animals increases spontaneous sleep and fatigue, and IL-1β increases with ongoing sleep loss.

Unlike IL-1β, IL-6 is not a direct somnogenic factor, but sleep loss results in increased IL-6 levels. In the gut, IL-6 and IL-1β mediated-inflammation fluctuate in response to stress and disease.

For example, intestinal mucositis results in increased expression of IL-6 and-IL-1β in the small intestine and in serum and colon tissue in mice. In humans, chronic stress alone increases IL-6 and-IL-1β.

Despite the close relationship between cytokine activity, gut microbiome activity and sleep, only a handful of studies have examined sleep and gut-microbiome composition … In humans, previous research has shown that partial sleep deprivation can alter the gut microbiome composition in as little as 48 hours …

A more recent study showed that high sleep quality was associated with a gut microbiome containing a high proportion of bacteria from the Verrucomicrobia and Lentisphaerae phyla, and that this was associated with improved performance on cognitive tasks.”

So, in summary, what this PLOS ONE study reveals is that the composition of your gut microbiome, the quality and quantity of your sleep, your immune function and cognition are all connected.

Lack of Sleep Makes Chronic Health Problems Extra Risky

The finding that poor sleep and lack of sleep can deteriorate your gut health helps explain why sleeping too little when you’re struggling with a chronic health issue could be a downright deadly prescription. As reported by CNN Health:17

“If you’re a middle-aged adult with high blood pressure, Type 2 diabetes or existing heart disease and you typically sleep less than six hours each night, you could be setting yourself up for cancer or an early death from heart disease.”

The study18,19,20 CNN is referring to was published in the October 2019 issue of the Journal of the American Heart Association (JAHA). In it, researchers sought to determine whether short sleep duration would increase the risk of death associated with cardiometabolic risk factors and cardiovascular and cerebrovascular diseases.

Data from 1,654 adults from the Penn State Adult Cohort were evaluated. Using Cox proportional hazard models, the adjusted hazard ratio for all-cause mortality among those who slept less than six hours and had cardiometabolic risk factors (high blood pressure, elevated glucose or Type 2 diabetes) was 2.14 times higher than those who regularly slept six hours or more.

They also had a 1.83 times higher risk of dying from cardiovascular or cerebrovascular diseases. Among those with a diagnosis of heart disease or stroke, sleeping less than six hours a night increased their all-cause mortality risk by 3.17 times. Interestingly, it also increased their risk of dying from cancer, specifically, by 2.92 times.

All of these associations were found to be independent of age, sex, ethnicity, obesity, smoking and other health conditions that might influence the results. Conversely, sleeping less than six hours did not increase the risk of death in those that did not have cardiometabolic risk factors or a cardiovascular or cerebrovascular disease diagnosis.

Likewise, those with cardiometabolic risk factors or a cardiovascular or cerebrovascular disease diagnosis who slept six hours or more were not at increased risk for death either. It was specifically the combination of chronic health problems and short sleep duration that increased the risk of death, including cancer mortality.

Sleep Duration Plays a Role in Mortality Prognosis

As noted by the authors:21

“Our novel findings show that objective short sleep duration increases the mortality risk of middle‐aged adults with CMRs [cardiometabolic risk factors] and those who have already developed CBVD [cardiovascular and cerebrovascular diseases].

Middle‐aged adults with CMR who slept <6 hours were at a high risk of dying from CBVD, whereas middle‐aged adults with CBVD who slept <6 hours were at a high risk of dying from cancer …

If these findings are replicated in other large cohorts with objective sleep measures, short sleep duration should be included in the prediction of the mortality prognosis of middle‐aged adults with CMR or CBVD.

The primary finding of the current study indicated that there was an ≈2‐fold risk for all‐cause, CBVD, and non‐CBVD mortality in participants who had CMRs at baseline and demonstrated short sleep duration in the sleep laboratory.

Individuals who had CMRs and normal sleep duration at baseline, on the other hand, did not show a significantly increased risk on any of the mortality outcomes. This finding suggests that obtaining an adequate amount of sleep may minimize the adverse effect of CMRs on multiple mortality outcomes.

For instance, participants with both CMRs and short sleep at baseline showed an 83% higher risk of dying from CBVD, whereas their CMR counterparts with normal sleep duration had a modest 35% nonsignificant higher risk of CBVD mortality …

In conclusion, objective short sleep duration is an effect modifier of the mortality risk associated with CMR or CBVD. More important, our data suggest that short sleep may operate through different mechanisms on CBVD versus cancer mortality.”

General Sleep Guidelines

Considering the massive importance of sleep for preventing the two top killers in the U.S. (heart disease and cancer), just how much sleep do you need to reap protective benefits?

According to a scientific review of more than 300 studies published between 2004 and 2014, a panel of experts came up with the following recommendations. Keep in mind that if you’re sick, injured or pregnant, you may need a bit more than normal.

Age Group Hours of sleep needed for health
Newborns (0 to 3 months) 14 to 17 hours
Infants (4 to 11 months) 12 to 15 hours
Toddlers (1 to 2 years) 11 to 14 hours
Preschoolers (3 to 5) 10 to 13 hours
School-age children (6 to 13) 9 to 11 hours
Teenagers (14 to 17) 8 to 10 hours
Adults (18 to 64) 7 to 9 hours
Seniors (65 and older) 7 to 8 hours

Set a Nightly Alarm to Help You Get Enough Sleep

There’s simply no doubt that sleep needs to be a priority in your life if you intend to live a long and healthy life. For many, this means forgoing night-owl tendencies and getting to bed at a reasonable time.

If you need to be up at 6 a.m., you need a lights-out deadline of 9:30 or 10 p.m., depending on how quickly you tend to fall asleep. If you find it difficult to get to bed on time, consider setting a bedtime alarm to remind you that it’s time to shut everything down and get ready for sleep. For further guidance, see “Sleep — Why You Need It and 50 Ways to Improve It.

How to Nurture Your Gut Microbiome

As for how to improve and maintain a healthy microbiome — which might do more to improve your sleep than is currently appreciated — it isn’t very complicated, but you do need to take proactive steps to encourage its health while avoiding factors known to cause harm. This includes:

Do Avoid
Eat plenty of fermented foods — Healthy choices include lassi, fermented grass fed kefir, natto (fermented soy) and fermented vegetables. Antibiotics, unless absolutely necessary, and when you do, make sure to reseed your gut with fermented foods and/or a high-quality probiotic supplement.
Take a probiotic supplement — Although I’m not a major proponent of taking many supplements (as I believe the majority of your nutrients need to come from food), probiotics are an exception if you don’t eat fermented foods on a regular basis. Conventionally raised meats and other animal products, as factory farmed animals are routinely fed low-dose antibiotics and GE grains loaded with glyphosate, which is widely known to kill many bacteria.
Boost your soluble and insoluble fiber intake, focusing on vegetables, nuts and seeds, including sprouted seeds. Chlorinated and/or fluoridated water — Especially in your bathing such as showers, which are worse than drinking it.
Get your hands dirty in the garden — Exposure to bacteria and viruses can help to strengthen your immune system and provide long-lasting immunity against disease.

Getting your hands dirty in the garden can help reacquaint your immune system with beneficial microorganisms on the plants and in the soil.

Processed foods — Excessive sugar feeds pathogenic bacteria.

Food emulsifiers such as polysorbate 80, lecithin, carrageenan, polyglycerols and xanthan gum also appear to have an adverse effect on your gut flora.

Unless 100% organic, they may also contain GMOs that tend to be heavily contaminated with pesticides such as glyphosate. Artificial sweeteners have also been found to alter gut bacteria in adverse ways.22

Open your windows — For the vast majority of human history, the outside was always part of the inside, and at no moment during our day were we ever really separated from nature.

Today, we spend most of our lives indoors. And, although keeping the outside out does have its advantages, it has also changed the microbiome of your home.

Research shows that opening a window and increasing natural airflow can improve the diversity and health of the microbes in your home, which in turn benefit you.23

Agricultural chemicals — Glyphosate (Roundup) in particular is a known antibiotic and will actively kill many of your beneficial gut microbes if you eat foods contaminated with it.
Wash your dishes by hand instead of in the dishwasher — Research has shown that washing your dishes by hand leaves more bacteria on the dishes than dishwashers do, and eating off these less-than-sterile dishes may actually decrease your risk of allergies by stimulating your immune system. Antibacterial soap — It kills both good and bad bacteria and contributes to the development of antibiotic resistance.
Sources and References

Vitamin D3

Written by Brenton Wight – LeanMachine, Health Researcher.

Health Facts on Vitamin D3 – the Natural Cure for all disease!

Why we need Vitamin D3
First, to help absorb calcium and other minerals to build strong bones with the help of Vitamin K2 that keeps calcium in bones instead of in blood where calcium plaques form.
Second, to build the immune system, in conjunction with gut bacteria – the other half of the immune system story.
Depending on which study we believe, optimal vitamin D3 can prevent between 50% and 90% of all cancers, as well as Multiple Sclerosis, and reduce the intensity or even cure almost every other disease.
If a drug company developed something that would do this, it would make headlines around the world and win a Nobel prize, and many billions of dollars would be saved in the health care budgets of countries everywhere.
If the entire population had optimal Vitamin D3 combined with a healthy diet, countless lives would be saved from cancer, many illnesses would disappear, most artificial replacements of hips and knees would not be required, thousands of people clogging up the nursing homes in their wheelchairs would be out playing tennis and leading active, productive lives.
Have I convinced you yet that just a few dollars for a year’s supply of super-strength 5000 IU Vitamin D3 would be a good investment in your future?
If not, then perhaps you should go and reserve that spot in the nursing home, and pick out the burial plot while you’re at it!

Benefits of Vitamin D3

Studies show that Vitamin D3 has cancer inhibiting properties, especially breast, prostate, pancreas, colon, skin cancer and leukaemia.
While millions are spent trying to find a cure for cancer, Vitamin D3 could be used to prevent cancer in the first place, at a cost equivalent to a drop in the ocean.
Vitamin D3 deficiencies can cause the following:
Colds and flu:
Vitamin D3 helps prevent or reduce severity of colds, flu, and almost every other infection. LeanMachine is living proof. After 10 years of taking Vitamin D3, no colds, no flu, no infections of any kind, not even a headache!
When we look at studies funded by drug companies who manufacture vaccinations, which are always biased in favour of the flu shot, the NNT (Number Needed to Treat) for the flu vaccine is 40, meaning that to protect one person from getting the flu, 40 people must receive the vaccination. Compare this with Vitamin D3, where the NNT is 33 in the average population, and in those people with D3 deficiency, the NNT drops to 4. In other words, for the average person, D3 is significantly better than the flu shot, and for those with low Vitamin D3, D3 supplements work 10 time better than the flu shot!
Most infections are naturally destroyed by our own immune system, mainly the T-cells, but T-cells need Vitamin D3 to operate correctly.
Studies funded privately, without the influence of the drug companies, have foud the flu shot to be even less effective, with those over the age of 65, or under the age of 2, or those on statin medications, all receiving NO statistically discernible benefit from the flu shot, and everyone else receiving a very marginal benefit such as a reduction in duration of illness of about 1 day.
On the downside, those taking the flu shot every year received less benefit (less protection), and actually INCREASED risk of coming down with a different strain of the flu!
More on vaccinations under the heading below.
OA (Osteoarthritis)
Osteoarthritis (OA)is the most common disease in people over age 50, more common than the common cold, and especially in women.
OA is directly linked to Vitamin D3 deficiency, and higher Vitamin D3 levels lower the risk.
Studies show that hip fractures in high risk population groups can be reduced by up to 40% by supplementing with Vitamin D3.
Partly because bones are stronger, and partly because people with good Vitamin D3 levels have much better balance and stronger muscles, so don’t fall over as much.

RA (rheumatoid arthritis) and MS (Multiple Sclerosis) appear to have the same link.

Obesity
Most Australians (two thirds) and others in Western society are overweight or obese.
Two thirds of people in Western society are also deficient in Vitamin D3, and this is no coincidence. There is a direct link between Vitamin D3 deficiency and obesity.
On average, the more Vitamin D3 deficient a person is, the more obese they are.
Healthy levels of Vitamin D3 are seen mainly in lean, healthy people.

Chronic pain
Chronic pain from any source can be reduced with Vitamin D3, even a simple headache, migraine, back pain, fibromyalgia, etc.
Many people with osteoporosis have chronic pain, typically lower back pain, often a sign of D3 deficiency.
Those people usually exercise less because of the pain, and insufficient exercise causes depression, worsens their osteoporosis, increases obesity, and their condition only gets worse.

Before 2010, LeanMachine suffered from headaches back pain and other pain, but no more. If I hit my thumb with a hammer, of course it hurts, and if I strain my back or another muscle, I feel stiffness that goes away in a day or two. But no other pain, no painkillers required, and in fact no painkillers of any kind kept in the house.

Cancer
Cancer is a devastating condition, but high levels of Vitamin D3 offer up to 80% or more protection, especially childhood cancers, breast, prostate, pancreas, skin and colon cancer.
A recent study confirmed that women with high levels of Vitamin D3 had about 85% reduced risk of breast cancer compared to those with the lowest levels of Vitamin D3.
Vitamin D3 is critical to the body’s production of GcMAF, a cancer-fighting protein that inhibits cancer metastasis, and is capable of reversing the devastating effects of cancer on the body. Vitamin D3 supports GcMAF synthesis, helping to shut down pro-cancer receptors and enzymes that encourage metastasis.
DBP-maf(Vitamin D3 binding protein-macrophage activating factor) is another protein reducing cancerous activity, which directly stimulates the immune response by suppressing angiogenesis (blood vessel growth) required for cancer cell migration and tumor growth. DBP-maf requires Vitamin D3 for transport in the bloodstream.

Depression
There are links between low levels of Vitamin D3 and depression.
For depression sufferers, LeanMachine recommends extra Vitamin D3 from sunlight because getting outside in the sun always lifts our mood. If we cannot get out in the sun, supplementation is a must.

Hearing Loss
Vitamin D3 deficiency weakens our bones, but when the three tiny bones (hammer, anvil and stirrup) in the ear become weak and spongy, attenuation of sound transmission results in hearing loss.

Allergies
Recent studies show that children with allergies have a high chance of being deficient in Vitamin D3, and those with the worst allergies, are over 80% likely to be deficient in vitamin D3.

Heart disease
The number one killer of Western society people is still cardiac disease.
Vitamin D3 deficiencies bring on high blood pressure, stroke and heart attack.
Number two is cancer, so we can alleviate both killers easily by eating a healthy diet and getting enough Vitamin D3 from sunlight and/or supplements.

Type 1 diabetes

Pregnant women who are deficient in Vitamin D3 are far more likely to produce offspring with Type 1 diabetes.
Any child deprived of sunlight in the first few years of life also has a far higher risk of type 1 Diabetes.

How do we get Vitamin D3 ?

We get Vitamin D3 from the sun, but we need the basic building-blocks in the body first.
The normal process of Vitamin D3 metabolism can be stopped by the deficiency of one single nutrient, so a healthy, nutrient-rich diet is essential.
In particular, we need cholesterol, which has been demonised for decades. More on this later.

Vitamin K2 – No Bones without it

Some people say we need Calcium for strong bones, but we get plenty of calcium from the diet, and we can absorb calcium with no problems as long as we have enough Vitamin D3.
No vitamin D3 means no calcium absorption, so adding more calcium to the diet without vitamin D3 means potential for calcium to form as plaque in our arteries, kidneys or other places where it will only damage the body.
Vitamin K2, which comes from animal products such as chicken, cheese, butter, eggs, etc, can help build bones by directing calcium to bones and teeth where it belongs, and helps keep our arteries, kidneys and other organs free from calcium.
The only vegetable source of Vitamin K2 is Natto (fermented soy), which explains why Japanese post-menopausal women have much stronger bones than Western women, as Natto is part of the traditional Japanese diet.
Vitamin K2 is not to be confused with Vitamin K (or K1), which is required for effective blood clotting, but not as effective as Vitamin K2 for bones, but still desirable in the diet.
K1 comes from intestinal bacteria as well as from green leafy vegetables like kale, spring onions, brussels sprouts, cabbage, broccoli, basil, asparagus, also prunes.
For vegetarians or vegans, supplementation of Vitamin K2 is essential as well as D3 for healthy bones. Vitamin D3 metabolism is complex, where each essential and critical nutrient provides the path to the next step, and one missing link in the chain will stop the entire process.
So it is no surprise that a third of our population is deficient in Vitamin D3, and around 90% are less than optimal. Unfortunately, these are the people who are at the highest risk of cancer.

Importance of Diet

Vitamin D3 cannot form without basic nutrients for the multi-stage process and this explains why so many people are deficient.

D3 – A Vitamin or a Hormone?

The answer is both.
It is a hormone (a chemical messenger) because it controls cells, organs, muscle and bone in everyday function, and because the body can manufacture it with sunlight exposure on skin.
It is a vitamin because it binds calcium so we can absorb it, as we humans cannot digest calcium without Vitamin D3, which maintains calcium and phosphate concentrations in the blood, providing minerals for bones, nerves, muscles, immune function, and lowers inflammation.
Many cell functions are controlled in part by vitamin D3, aiding in weight loss, blood glucose regulation, metabolism, and essential fatty acids (Omega-3) processing.
There is no point taking calcium or omega-3 foods or supplements without a good supply of Vitamin D3.
Almost every cell in the body has Vitamin D3 receptors, so Vitamin D3 is a crucial nutrient.
Vitamin D, D2 or D3?
The terms Vitamin D and vitamin D3 are used interchangeably here. D3 is the correct and natural Vitamin D.
D3 exists in the body as the storage form 25(OH) and the active form 1,25 2(OH). Vitamin D2 (ergocalciferol) is an artificial version of Vitamin D3 (cholecalciferol), or vitamin D coming from some foods.
D2 has very low affinity for DBP (vitamin D binding protein) so it cannot be easily stored and should never be used.
Firstly, D2 has nowhere near the healthy properties of D3 (cholecalciferol), and secondly, D2 tends to block absorption of the real D3.
Many foods come “fortified with vitamin D” but this is invariably an artificial D2 with poor benefits.
Some early medical studies on vitamin D used inferior synthetic D2 which is toxic at much lower doses, and unfairly discredited the real D3 which was not even being used in the studies.

How is Vitamin D3 made?

We get vitamin D3 from sunlight, food or supplements.
D3 from sunlight
Most people know we get Vitamin D3 from sunlight, but there is a multi-stage process involved.
Production starts in the liver, which makes 7-dehydrocholesterol, which then migrates to the skin to be altered by UVB (ultra-violet light in the B range) to become pre-vitamin D3.
This is carried back to the liver to be mediated by an enzyme (25-hydroxylase) to become 25-hydroxyvitamin D, where a hydroxy (OH) molecule is added to build the storage form 25(OH).
This is then transported to the kidneys to be mediated by yet another enzyme (1-alpha-hydroxylase) to finally become calcitriol, where a second hydroxy (OH) is added. This is the active form of vitamin D3, also known as cholecalciferol or 1,25 dihydroxyvitaminD3 or the active form 1,25 2(OH). Dihydroxy means that the D3 molecule has two OH molecules added, one from the liver and a second from the kidneys.
Vitamin D3 is carried in the blood by DBP (vitamin D-binding protein).
This entire process takes around 15 days, so if we shower every day, we “wash off” most of the pre-vitamin D, so morning showers are best, allowing the pre-vitamin D to start the migration back to the liver before the next shower.
And a day at the beach won’t help our vitamin D3 if we go for a swim, and worse if we get sunburnt!

Statins rob our Vitamin D3

As we age, we lose the ability to synthesise vitamin D from sunlight, and those on statin medication (half the aged population) cannot make 7-dehydrocholesterol, co-enzyme Q10, Cholesterol Sulfate and other important requirements for the body, because when statins slow the liver production of cholesterol, all of the above are affected.
No one should ever take a statin drug (Lipitor, Crestor, Simvastatin and others) other than exceptional circumstances, as they generally do much more harm than good.
Independent studies show that while some deaths from heart disease are reduced, deaths from ALL OTHER CAUSES is INCREASED by statin medication! Taking statins, we will generally not live one day longer, and will have a poorer quality of life.
Also as we age, we generate less stomach acid, losing the ability to take in B12, Methyl Folate (never Folic Acid!), Vitamin K2 and other nutrients that vitamin D requires to do it’s job. If we get reflux or heartburn, doctors normally prescribe Nexium or antacids, which may relieve symptoms short-term, but only make the problem worse. The best way to cure heartburn is to eat less, and eat an alkaline-forming diet, but that is another story in my Alkaline Diet article.
Those who dress fully covered for cultural reasons or those with dark skin always need more vitamin D.
Annual blood tests for vitamin D3 are advisable if taken at very high doses as excess levels can become toxic.
For adults, toxic levels for vitamin D3 are generally not seen unless we take in some 40,000 IU daily for many weeks.
Vitamin A can also be toxic in high levels, but if A and D are taken together, the toxic levels are some 5 times higher for both A and D, giving a huge margin of safety, so old “toxic levels” should really be called “imbalance levels”.
Another factor is Vitamin K2, discussed later.

Other things that Steal our Vitamin D3

Being overweight – the more overweight we are, the less bioavailable Vitamin D3 becomes. But if we take Vitamin D3 supplements and/or get more sunshine, this will assist our weight-loss efforts!
Being old – as we age, our ability to absorb D3 from sunlight and from food reduces, so supplementation becomes more essential.
BPA (Bisphenol A) – BPA (Bisphenol-A) and other endocrine-disrupting chemicals reduce our Vitamin D3 levels. Avoid foods in plastic or cans and use glass containers.
Liver problems – a poor liver produces less bile, which reduces absorption of Vitamin D3. Look after the liver – avoid excess alcohol and eat a healthy diet of quality fats, few carbohydrates, and low to moderate protein.
Kidney problems – as kidney disease gets worse, so do Vitamin D3 levels. Look after kidneys by drinking plenty of clean water and eating a healthy diet
Gut bacteria – these 100 trillion organisms are a major component of our immune system, and also aid in absorption and processing of minerals and vitamins, including Vitamin D3. People with celiac disease, chronic pancreatitis, IBS (irritable bowel syndrome) or Crohn’s disease, or those taking antibiotics, will all have reduced D3, so essential supplements are Vitamin D3 and probiotics.
Slip, Slop, Slap in the face campaign – this disastrous campaign has been running for over 30 years in Australia, costing the taxpayer many millions of dollars, and has caused many more millions in extra health care, more disease, and many more lives lost.
True, reduced sunlight has reduced the number of mostly harmless skin cancers such as basal cell carcinoma and squamous cell carcinoma which are easily treated, and rarely turn into something more serious (less than 1% of cases).
But the number of MELANOMA cancers – the real, deadly kind, has DOUBLED, but this fact has been hidden by the Australian Cancer Council who are behind the Slip, Slop, Slap campaign! The primary reason, of course, is lack of Vitamin D3 due to reduced sunlight, reducing immunity.
Melanomas also appear on the soles of feet, in armpits and other places where sunlight is very limited, but so-called “specialists” still blame the sun!
The science cannot be denied. The closer one lives to the Equator, the less chance of any type of cancer, a proven fact.

Too much sunlight?

If we get D3 from sunlight, then surely if we spend all day in the sun, like construction workers and other outdoor activities, we should get plenty?
Wrong. After we spend around 10 to 20 minutes in the sun in the middle of the day (90 minutes for dark-skinned people), we reach a point where the body will no longer synthesise any more vitamin D3.
This is the way the body is designed to prevent toxic levels from building up, and also the reason why we get a tan – to prevent too much vitamin D3 from the sun.
If our skin starts to get the slightest shade of pink, it is time to cover up or seek some shade, as more sun will only then cause damage, with no extra vitamin D3 past that point.
And if we get a healthy dose of sunlight one day, we can happily work inside the next day, as it may take 2 days to build new skin resources for more absorption.

The Morning Myth

The cancer society and other “health” organisations all say the we should avoid the sun in the middle of the day, and only go out in the morning or the evening when the sun is low in the sky. Wrong again!
This is actually the complete reverse of the truth!
The sun produces ultra-violet rays in three bandwidths, named UV-A, UV-B and UV-C, each with different properties.
UV-A
We get UV-A from all sunlight, no matter what time of day, and it passes through cloud and glass, and this kind travels deeper into the skin, causes skin damage and ZERO vitamin D production.
We can sit by a window or in a car with windows up, on a hot sunny day and never get any vitamin D.
We can be outside all day when there is cloud cover, but we will never get any vitamin D.
All we get from UV-A is skin damage.
UV-B
We get UV-B ONLY from a clear blue sky, and ONLY when the sun is HIGH in the sky. This is the “good” sunlight, as this is the ONLY kind that gives us vitamin D.
When the sun is lower in the sky, most UV-B is absorbed in the atmosphere leaving little or none for our benefit.
We need 10 minutes a day (fair-skinned) to 20 minutes a day (tanned) with the sun high in the sky, no clouds, and no glass. This can give us all of the vitamin D we need, but for many, this is impossible.
For those living a long way from the equator, or out of the tropic areas in winter, those working shifts or indoors, those who cover their entire bodies for religious reasons, or slap on sunscreen, those who have very dark skin, those on statin medication, those on a poor diet, those confined to hospitals or nursing homes and others who mistakenly believe the sun is evil, will never get enough vitamin D.
Vitamin D is fat-soluble, meaning that if we get plenty one day and miss the sun for a few days, we will still be able to call on our vitamin D reserves stored in fat cells.
Of course, UV-B will still damage our skin if we stay out in the sun too long.
UV-C
UV-C rarely gets to Earth as it is almost completely absorbed in the atmosphere, so is of little concern unless you are an astronaut.

Why we NEED sunlight, more than just for Vitamin D3

The human body is designed to thrive in sunlight, and it is not only the Vitamin D3 benefit.
A 20-year study of over 29,000 people found that those avoiding sun exposure had double the death rate from all causes!
This study did not measure D3 levels, but results from other D3 studies show that the high death rate from insufficient sun exposure can not be accounted for only by low Vitamin D3.

We also get Cholesterol Sulfate from sunlight on the skin.
Cholesterol sulfate protects red blood cells from breaking up. Without enough cholesterol sulfate, we get a condition called hemolysis, where the red blood cells die prematurely, spilling their contents into the blood.
Without sulfur, and without the sun, we cannot make cholesterol sulfate, a molecule which is both fat-soluble and water soluble, which is essential for the body to distribute cholesterol and sulfur throughout the body.
All artery walls have an endothelial lining, and these endothelial cells cannot work correctly when depleted in sulfate. They cannot control what gets into and out of cells, which promotes cardiovascular plaque.
Cholesterol Sulfate, in conjunction with it’s nitric sister, eNOS, determines how thick or thin or blood becomes. Sulfate makes it thicker, nitric makes it thinner, and this automatic regulatory system works very well as long as we have supplies of both, for which we need sunlight.
Interestingly, one thing that messes up these molecules is glyphosate (“Roundup” and other weedkiller trade names) so this is a good reason to avoid all GM (Genetically Modified) foods, which are all heavily sprayed with glyphosate.
Sulfur is incredibly important for health. Cholesterol sulfate protects against bacterial and virus infections and strengthens the immune system.
Cholesterol sulfate is essential for babies. Women normally have about 1.5 units of cholesterol sulfate in the blood, but in pregnancy, levels rise in the villi of the placenta to around 24 units!
Foods high in sulfur include eggs, beef, garlic, onions, sprouts, asparagus, kale, coconut oil, olive oil, but only where they are grown or raised in sulfur-rich soil (think organic).

Vitamin D sulfate is also made from sunlight, and is both water and fat soluble, so it can go anywhere in the body, distinct from the regular fat-soluble Vitamin D3 I have been talking about. Same with cholesterol sulfate. Not only is it both water and fat soluble, it can travel through the body on it’s own, where many other substances need to be “carried” by cholesterol wherever they need to go.
If we want healthy blood, we MUST have sunlight!
Humans make several other important peptide and hormone “photoproducts” when skin is exposed to UVB sunlight:

  • β-Endorphins are natural opiates that induce relaxation and increase pain tolerance
  • Calcitonin Gene-Related Peptides are vasodilators (expand blood vessels) that protect us from hypertension (blood pressure), vascular inflammation, and oxidative stress
  • Substance P is a neuropeptide that increases blood flow and also regulates immune system response to acute stressors
  • Adrenocorticotropic Hormone is a polypeptide hormone, controlling cortisol (stress hormone) release by the adrenal glands, regulating immune system and inflammation
  • Melanocyte-Stimulating Hormone is a polypeptide hormone, reducing appetite, increasing libido, and increasing skin pigmentation

Sunlight contains a beneficial EMF (electromagnetic frequency) that is essential for health.
40% of sunlight is infrared, and the red and near-infrared frequencies interact with CCO (Cytochrome C Oxidase). CCO is a protein in the inner mitochondrial membrane, also part of the electron transport chain. CCO is a chromophore (a molecule that attracts and absorbs light), so sunlight improves ATP (the generation of energy). The optimal wavelengths for CCO are red at 630 nm to 660 nm (nanometers) and near-infrared at 810 nm to 850 nm.
LeanMachine gets sun exposure as often as possible. Others afraid of the sun may consider photobiomodulation therapy (use of near-infrared light treatment).
UVA exposure is generally considered harmful, as this is the most damaging kind of exposure for skin with no ability to generate Vitamin D, however there are benefits such as releasing NO (Nitric Oxide), discussed above. An important cellular signaling molecule that dilates blood vessels and reduces blood pressure.
This is closely tied to another molecule, eNOS (endothelial nitric oxide synthase) which regulates the “thickness” of blood. When blood becomes too thick, eNOS makes more nitric oxide which expands blood vessels and thins the blood. When blood is too thin, eNOS makes more sulfate. Sulfate is essential for the endothelial lining of all blood vessel walls. If we are low in sulfate, the wall can start breaking down and clots start to form to repair the damage. We can get more sulfur in the diet from onions, garlic, broccoli, egg yolks and other foods, or by supplements such as MSM (MethylSulfonoyl Methane) but we still need sunlight to make cholesterol sulfate which can be distributed through the body to keep us alive!

Apart from photoproducts, nitric oxide and cholesterol sulfate production, sunlight is essential for our circadian rhythm (body clock). Sunshine activates neurons in the suprachiasmatic nucleus of the hypothalamus, sending signals to the pineal gland which regulates production of the hormone melatonin. When the circadian rhythm is upset, melatonin and other hormone production is disrupted, leading to mood problems, poor cognition (thinking), metabolic syndrome (leads to diabetes) and increased risk of cancer.

Tanning Beds

Tanning beds are famous for increasing risk of melanomas, the most deadly form of skin cancer.
Tanning beds have been outlawed in all States of Australia, except in the Northern Territory, where they are still legal, but there are no commercial solariums there because the tropical climate makes sunlight tanning easy. However, this is seen by some as a knee-jerk reaction by politicians to win votes.
Most tanning beds produce UV-A and UV-B radiation, but some better units are available which produce only UV-B, which are much safer if used correctly.
Staying too long in even a quality tanning bed will cause skin damage, a precursor to many forms of skin cancer. Tanning beds that emit high levels of UV-A should be avoided completely.

Vitamin D3 from food

We get some vitamin D from the diet. Eggs, fish, cod liver oil are all good sources, and also come naturally with Vitamin A, but it is almost impossible to get enough D3 from the diet, so we must top up our D3 from sunlight or supplements or both. Milk contains some vitamin D, but calcium and vitamin D in milk are very poorly absorbed. Asian women are more likely than white women to be diagnosed with osteoporosis, so doctors claim this is caused by low milk consumption, but Asian women are much less likely to have a hip fracture (the worst kind), indicating that traditional DEXA scans (bone density tests) do not mean much, as dense bones are often not as strong as less dense but more flexible bones.
Africans generally have stronger bones than caucasians, even though they get less vitamin D3 from sunlight. They appear to be much more sensitive to the sunlight they do receive.

VitaminD3 from supplements

Most Vitamin D3 sold in Australia from chemist shops or supermarkets contain 1000 IU which may be enough to prevent rickets in young people, but is nowhere near optimum for immunity and bone strength, especially in older people, and not enough for anyone except small children to have an optimal immune system.
LeanMachine recommends Vitamin D3 5000 IU daily for almost a year’s supply, and this is the cheapest health insurance anyone can buy!
Vitamin K2 is also recommended, as this combination helps put calcium where it belongs, in bones and teeth, and reduces calcium buildup in blood vessels (arterial plaque).
Vitamin A is also recommended for health benefits as well as to eliminate any chance of toxicity.

No Cholesterol means no Vitamin D3

As explained above, cholesterol is the building-block for vitamin D3, also for every hormone in the body and many other functions.
About half the adult population over 60 in Australia and the USA is taking statin medication.
Sold under many names including Simvastatin, Lipitor, Advicor, Lovastatin, Mevacor, Vytorin, Zocor, Lipex, Simcor, Crestor, Pitavastatin, Pravastatin, Rosuvastatin, Fluvastatin, and Cerivastatin (withdrawn 2001).

The Lies about Cholesterol

Statins do lower cholesterol, but we NEED cholesterol, it is NOT the enemy it is made out to be. Yes, cholesterol is found in a badly inflamed body, but this is because the liver makes more cholesterol to repair damage caused by the inflammation, which is the REAL cause of poor health.
Statins reduce cholesterol by preventing the liver from producing as much cholesterol, but the job of the liver is to make cholesterol as required.
If we eat cholesterol foods (such as meat or eggs) the liver makes less, if we eat no cholesterol (such as a vegan diet), the liver makes more, which is the way it should be.
When statins are used, they attempt to shut down this natural process, and in so doing, also shuts down co-enzyme Q10 which is vital for healthy muscles.
And the heart is the most important muscle in the body – why clobber it with statins?
Statins also stop production of 7-dehydrocholesterol, so then we get almost zero vitamin D3 from sunlight.
Statins have shown no benefit to women whatsoever in many studies.
For men who have had a heart attack, statins have shown a slight reduction in deaths from future heart attacks, but in all patients, statins cause an INCREASE in deaths from all other causes!
Because statins knock out our Co-enzyme Q10 (often called the spark-plug for the heart), the patient can suffer extensive muscle damage, causing pain, reduced mobility and even death.
Drug companies say they have no idea what causes this increase in death from statins, but the answer is obvious to me – low vitamin D3!
Studies show that treatment with one fish oil capsule daily prevented 9% of deaths in cardiac patients over 4 years, while those given the Crestor statin drug had an INCREASED death rate of 1% over the same period.
The Framingham study, the biggest and longest study ever, showed that those with the lowest cholesterol died first, and those with the highest cholesteol lived longest!
But the drug companies continue to perpetuate these cholesterol lies to maximise profits from their biggest-selling drug.

How much D3 do we need?

The older we get, the more vitamin Vitamin D3 we need.
The only way to know how much we have is by a blood test, because ethnic background, skin colour, amount of tan, food, medication, supplements, geographic location, sun exposure, clothing, sunscreen, exercise, BMI and many other factors determine how much Vitamin D3 we absorb and retain.
Vitamin D3 is a fat-soluble vitamin, so daily levels do not vary much, as every fat cell in the body can store D3.
Always ask the doctor for a printed copy of your results so you can compare with any previous test and also get a true reading.
Unfortunately, most Australian labs say we need 60 to 160 nmol/L of D3, which is inadequate. Better labs say 75 nmol/L is the minimum, but we need more.
Values above 60 will prevent us from getting rickets, but will not give us good immunity.
For optimal immune system function, we should aim for the high end of the range of 125 to 175 nmol/L.
If we are battling cancer or some other serious disease, we should aim for 175 to 250 nmol/L but this requires careful monitoring and extra Vitamin K2 and Vitamin A to prevent toxicity.
Supplement values vary, and the RDA (recommended Daily Allowance) of 60 IU was alarmingly too low, and changed to 400 IU, originally determined as the minimum amount to prevent rickets.
Even the 400 IU allowance typically gives a blood test of 40 to 60 nmol/L which may barely stop rickets but will not provide a strong immune system.
Conservative studies determine that infants less than one year old need 400 IU daily, 1 year to adolescents need 400-600 IU daily, adults need 400-600 IU daily, and adults aged over 70 years need 400-800 IU daily.
More modern studies recommend babies take 400 IU, children 1000 IU, adults 4000 IU, and those over 70 may need 8000 IU daily.
Small doses are fine for strong bones, but for a strong immune system to ward off all disease, high doses are a must.
LeanMachine has taken 5000 IU daily for over 10 years, and has zero colds, flu or any other illness, not even a headache!

But don’t I get my Vitamin D3 from Milk?

Sorry, but you do not!
I was told to drink milk as a youngster, some 6 decades ago, and milk does indeed contain vitamin D and calcium, but these and other nutrients in milk are poorly absorbed in the gut.
Worse, pasteurised milk has most of the nutrients heated out of it, and homogenisation is very BAD for our health.
Homogenisation is a process making each fat globule 10 times smaller than normal, to save us the trouble of shaking the milk container to disperse the cream. The problem then is that these tiny fat globules then enter the bloodstream through imperfections in the gut lining, often referred to as “leaky gut syndrome”. When raw milk fat enters the blood directly like this, the immune system detects this as a foreign substance, and begins attacking these fat globules, and marks them as invaders. Now when we consume milk the regular way, and absorb it naturally through a healthy intestine, the immune system starts attacking this as well, as it has already been recognised as a foreign invader. The result: Allergies to Lactose, one of the main ingredients in milk, has reached epidemic proportions in the last few decades where homogenisation has become standard practice. Vitamin D3 can help stabilise an over-reactive immune system, but the only safe way to drink milk is to only use NON-HOMOGENISED milk. Most supermarkets have it, but you have to look past the big-name brands to find it.
In many countries it is against the law to buy non-pasteurised milk, but we can at least buy non-homogenised milk if we feel we must have milk (and we do not need milk).
Some Asian countries have diets where milk is non-existent, and their bones are stronger, and broken bones are rare.
We get more useful Vitamin D3 from broccoli and other fresh vegetables than from milk!
Milk is also BAD for our bones, as it is acid-forming in the body, and all acids in the blood cause an immediate reaction in the body to neutralise the blood acid (otherwise we die!).
This reaction, controlled by the parathyroid glands, leaches potassium, calcium and magnesium from bones, teeth and organs, the fastest way the body can neutralise the acid.
If we must drink milk (and we do not have to for a healthy diet) then the ONLY milk to buy is FULL CREAM, UNHOMOGENISED milk, which you can find at good supermarkets if you look hard enough.
The only better product is the milk straight from the cow, or better still straight from mother’s breast (most mothers will not be impressed if you ask for milk this way!)

Getting enough of the right Vitamin D3

Sunlight is still the best way to get enough Vitamin D3 and Cholesterol Sulfate, but for many, this can be difficult or impossible.
Supplements are the next best choice, but the supplements we buy at Chemist shops or supermarkets in Australia have only around 1000 IU of Vitamin D3.
They are also often combined with Calcium, which LeanMachine does NOT recommend, but that is another story.
While this is better than nothing, most people require 5 to 10 times this much to bring their levels to “optimum”.
For most health specialists, “optimum” means over 60 or 75 nmol/l (30 ng/ml), and if your results come in at over this threshold, the doctor will say you are fine.
However, true experts in this field say that truly optimum for a normal healthy person for immunity to disease, is between 125 and 175 nmol/L (50 – 70 ng/ml).
For those recovering from a serious disease, optimum should be 175 to 250 nmol/L (70 – 100 ng/ml).
Vitamin D3 can be toxic at high doses for extended periods, so continuous levels over 250 nmol/L (100 ng/ml) should be avoided.
Blood tests are advised for all very high-dosage patients.
People most at risk of deficiency are the elderly, those with with dark skin, those who cover their body with clothing or sun screen, or work night shifts or underground and never see the light of day, and those who live furthest from the equator or in cloudy climates.
Those at risk may need 10,000IU daily supplements, the rest of us can usually get plenty with 5000IU, and the very young who get plenty of sunlight on a regular basis may not require any.
Remember that we only get Vitamin D3 from sun in a blue sky when the sun is high, from the UVB (Ultra-Violet light in the “B” range”).
When the sun is low in the sky, or when there is cloud, or when the light comes through a glass window, UVB is blocked and we only receive UV-A which is the damaging, cancer-causing radiation with Zero Vitamin D3 benefits.
Other tests: Depending on the condition, the doctor may order other tests to check for liver and kidney disease as well as a full blood count.
A full blood test for Vitamin D3 is:
25-hydroxyvitamin-D (25-D or D2/D3) or 25(OH)D or simply 25-D
1,25-dihydroxyvitamin-D3, or 1,25(OH)2 D3, or 1,25 2(OH), or simply 1,25-D
Most doctors will only test for 25(OH)D which is the storage form, which is fine for most people.
For those suspected of having Sarcoidosis (a rare condition) then both must be tested, and vitamin D supplementation and sunlight should be avoided altogether unless the active form 1,25(OH)2 is tested low.

Vaccinations

There are many reports of children suffering from Autism and other serious conditions after vaccinations.
Vitamin D3 supplements should be taken for at least 1 week before any vaccination to reduce risk of unfortunate reactions.
Panadol, Panadeine, Paracetamol, Tylenol, Acetaminophen, Atasol, etc must NEVER be taken before or after any vaccination, even though doctors incorrectly recommend it to reduce pain and fever.
Autism rates in the USA are 1 in 45, while Autism rates in Cuba are 1 in 12,000.
A few decades ago, Austism rates were only around 1 in 200, before Panadol (Tylenol, Acetaminophen in the USA)
Cuba has a high vaccination rate of 97%, but the difference:
These over-the counter pain medications are prescription-only items in Cuba.
Of course, no drug company is interested in conducting a study where the result may be that their “safe and effective” product causes Autism, but as far as LeanMachine is concerned, Vitamin D3 reduces the risk of sickness from almost any disease.
Besides Autism, Panadol can destroy liver function (most patients on the liver transplant waiting list are there because of Panadol), and Panadol is also acted upon by enzymes which then destroy the body’s reserves of L-Glutathione, the natural “Master Antioxidant” in the body.
If you want your child vaccinated anyway, DO give them vitamin D3 and DO NOT give them any pain or fever medication.
A little fever is the body’s way to fight the toxins in the vaccination and the best way to deal with it is to let it run it’s course.
However, a very high fever can lead to convulsions, especially in small children. The best way to bring down a very high fever is to place the child in a cool to lukewarm bath and keep water over the skin using a sponge or cloth.
No drugs required, and much safer and more effective than any drug.
Better still, vaccinations can be avoided altogether for those with a strong immune system.
For more information on vaccinations, see this article: Vaccinations.

Autoimmune conditions

Allergies, hives, arthritis, lupus, psoriasis, rheumatoid arthritis, thyroid disease, multiple sclerosis, etc, are all autoimmune conditions.
Little help is available from medications which merely help to ease symptoms.
Vitamin D3 builds the immune system and protects us from colds, flu and other diseases, but Vitamin D3 is also an Immune Moderator, helping to dampen the effect of the immune system over-reacting, the cause of auto-immune disease.
Vitamin D3 can also help treat the cause of the symptoms, often Helicobacter pylori (H. pylori), found in over 70% of autoimmune patients.
H. pylori can invade the gut via contaminated water or food, or from contact with infected people or animals, causing gut inflammation, disrupting the immune system.
Vitamin D3 effectively destroys H. pylori and restores the immune system, often reducing allergy symptoms by 30% in seven days, and another 40% in 12 weeks.
H. pylori infects around 30% of adults in the western world, more if we are over 60 with low Vitamin D3 levels.
A blood test can give your D3 levels, but the lab will say 60 to 75 nmol/L is OK, but we need 125 nmol/L minimum to destroy H. pylori.
Mushrooms, eggs, wild-caught salmon, etc have natural Vitamin D3 but the modern Western diet is lacking in these. Mushrooms grown in the dark will have no vitamin D3, but 30 minutes of exposure to direct sunlight can generate significant D3 levels.

Vitamin D3
The latest science Says: “It’s not just about bones, it’s about your total well-being!
Professor Michael Holick:
We now think that maintaining adequate Vitamin D3 levels are important for decreasing the risk of prostate cancer, breast cancer and colon cancer.
There is some evidence that in young children if they are fortified with vitamin D3 from 12 months old it can reduce the risk of type 1 diabetes by 80%“.
Professor Philip Sambrook:
We have always thought it could not happen in Australia – it is too sunny a country. However, people do not get sunlight for various reasons and if you do not get some sunlight you do not make vitamin D3. We do not get it much in food any more so for that reason, deficiency is quite common. And the vitamin protects healthy cells while also killing cancer cells.”

LeanMachine online supplements

Note: This online supplement shop is now closed, but each product page contains a link to the best supplier of that product.

Disclaimer

LeanMachine is not a doctor, and everyone should consult with their own health professional before taking any product to ensure there is no conflict with existing prescription medication.
LeanMachine has been researching nutrition and health since 2010 and has completed many relevant studies including:

  • Open2Study, Australia – Food, Nutrition and Your Health
  • RMIT University, Australia – Foundations of Psychology
  • Swinburne University of Technology, Australia – Chemistry – Building Blocks of the
  • World
  • University of Washington, USA – Energy, Diet and Weight
  • Johns Hopkins Bloomberg School of Public Health, USA – Health Issues for Aging
  • Populations
  • Johns Hopkins Bloomberg School of Public Health, USA – International Nutrition
  • Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics I
  • Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics II
  • Johns Hopkins Bloomberg School of Public Health, USA – Principles of Human Nutrition
  • TUFTS University, USA – Nutrition and Medicine
  • TUFTS University, USA – Lipids/Cardiovascular Disease I and Lipids/Cardiovascular Disease II
  • Technical Learning College, USA – Western Herbology, Identification, Formulas
  • Bath University, England – Inside Cancer
  • WebMD Education – The Link Between Stroke and Atrial Fibrillation
  • WebMD Education – High Potassium: Causes and Reasons to Treat
  • Leiden University Medical Center, Netherlands – Anatomy of the Abdomen and Pelvis
  • MIT (Massachusetts Institute of Technology) – A Clinical Approach to the Human Brain

LeanMachine has now examined thousands of studies, journals and reports related to health and nutrition and this research is ongoing.

Updated 11th January 2020, Copyright © 1999-2020 Brenton Wight and BJ&HJ Wight trading as Lean Machine abn 55293601285