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Can glutathione help combat fatty liver disease?

Reproduced from original article:
www.naturalhealth365.com/glutathione-liver-disease-3311.html

glutathione-detox(NaturalHealth365) Glutathione – a powerful antioxidant that’s found within every cell of the body – is made up of amino acids. This antioxidant contributes to a variety of important bodily functions, including vitamin regeneration, breaking down free radicals, immune system support, helping the liver to handle fats, making DNA, and even the creation of sperm cells.  But, unlike many other antioxidants, the body is actually able to make this substance in your liver.

Researchers have previously found links between certain diseases and low glutathione levels.  Since the antioxidant plays an important role in the antioxidant and detoxification systems of cells, scientists hypothesized that glutathione supplementation would help combat fatty liver disease.  And in a fairly recent study, researchers investigated oral supplementation in individuals with nonalcoholic fatty liver disease (NAFLD) with positive results.

The proper amount of glutathione proves to be beneficial for people with fatty liver disease

The study involved 34 patients with nonalcoholic fatty liver disease, all of whom had been diagnosed via ultrasonography. First, patients underwent lifestyle interventions, such as diet and exercise changes for a period of three months.

Then, patients were treated with 300 mg per day of glutathione. Clinical parameters like liver fat, liver fibrosis, and alanine aminotransferase (ALT – a blood test that checks for liver damage) levels were all checked both before and after treatment with glutathione.

Among the patients who finished this protocol, a significant decrease in ALT levels were seen after treatment with glutathione.  Patients also so decreases in ferritin, triglyceride, and non-esterified fatty acid levels.

Overall, the study demonstrated that oral supplementation of glutathione does offer some significant potential therapeutic effects for patients with fatty liver disease, although study authors note that larger-scale clinical trials should be done for verification.

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Powerful antioxidant offers additional health benefits

Beyond this new study showing the benefits of glutathione for individuals with liver disease, the powerful antioxidant offers a number of additional health benefits as well.

Benefits include:

  • Counteracting free radicals: As an antioxidant, it helps fight free radicals, protecting your body from their damaging and aging effects.
  • Improves insulin sensitivity: One study showed that individuals who have insulin resistance often have low glutathione levels.
  • Combating cancer: Some research shows glutathione may help prevent cancer progression as well.
  • Alleviate symptoms of Parkinson’s: Research shows that maintaining healthy levels of glutathione may help alleviate or at least reduce symptoms associated with Parkinson’s disease.
  • Boosting the immune system: By protecting cell mitochondria and reducing inflammation, glutathione helps boost the immune system.

Although glutathione offers a number of proven health benefits, as you grow older, levels of glutathione decrease.  Injury, stress, and illness can all affect glutathione stores, as well.

Therefore, eating an organic diet, reducing or eliminating smoking and alcohol consumption, and avoiding exposure to environmental toxins can help prevent glutathione depletion.  Naturally, adding a glutathione supplement to your diet in the amount of 200 – 500 mg per day may also prove helpful, although you should always talk to your integrative physician before making any changes to your diet or supplement routine.

Sources for this article include:

NIH.gov
NaturalHealth365.com
MedicalNewsToday.com

Popular pain reliever triggers 20 percent of liver transplant cases

Reproduced from original article:
www.naturalhealth365.com/pain-reliever-liver-transplant-3305.html

pain-reliever(NaturalHealth365) Go ahead and place your hand on the upper right part of your abdomen. Right beneath your palm is a football-sized organ that plays an important role in detoxifying your body and helping with digestion. This organ is your liver – do you know if yours is healthy?

Turns out, liver disease signs and symptoms can be hard to notice – which is why Jonathan Landsman created the Fatty Liver Docu-Class, available now.

You may also be surprised to know that liver disease and other types of damage can occur due to unintended drug effects of medications, including the extremely popular NSAIDs.  Could our nation’s dependency on prescription and over-the-counter drugs contribute to the prevalence of liver transplant surgery?

Taking a popular pain reliever can damage the liver and INCREASE the risk of heart disease

In August 2019 a team of researchers published a paper in Journal of Cardiovascular Pharmacology and Therapeutics that set out to investigate the health risks associated with nonsteroidal anti-inflammatory drugs, or NSAIDs including ibuprofen (Motrin or Advil), aspirin, and naproxen (Aleve).

Here’s some of their findings based on a large pool of data from other studies:

  • Side effects of these drugs are responsible for at least 100,000 hospitalizations and 17,000 deaths per year in the United States.
  • More than half of liver failure events caused by drug overdose and 20 percent of liver transplant surgeries are caused by acetaminophen (about 8,000 liver transplants occur every year in the U.S.). Meanwhile, anywhere from 80 to 100 million Americans have nonalcoholic fatty liver disease and don’t know it!
  • NSAIDs (not including aspirin) are also linked with an increased risk for cardiovascular problems including stroke, heart failure, and electrolyte imbalances.
  • Even the Food and Drug Administration has had to recently expand their warnings about NSAIDs and their potential role in contributing to cardiovascular disease (CVD).

Overall, the research on NSAID drug effects and the unintended harmful impacts they can impose on the body has a lot of holes, and the researchers of this paper understandably state that there needs to be more.

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In the meantime, the authors call for “judicious individual clinical decision-making about the prescription of NSAIDs” and advise healthcare providers to “consider all these aforementioned benefits and risks, both CVD and beyond, in deciding whether and, if so, which, NSAID to prescribe.”

Curb your NSAID intake with these 5 natural pain relievers instead

Controlling and minimizing chronic pain can have a huge impact on the quality of your life and your ability to earn money, enjoy your hobbies, stay independent, and enjoy time with your loved ones.

If you’re tired of relying on expensive medications that are causing unintentional effects on your health and organ function, check out these natural pain-relieving options and find out how they can help you:

  1. Turmeric, a powerful anti-inflammatory
  2. Acupuncture and other holistic treatment options
  3. Exercise: Just don’t overdo it
  4. Aloe vera, which has both anti-inflammatory and analgesic properties according to the U.S. Pain Foundation
  5. Mindfulness practices, including four square breathing, meditation, and progressive muscle relaxation

And remember: our team at NaturalHealth365 doesn’t provide medical advice, and we do not recommend making any changes to medication without approval from your physician, so be sure to chat with your doctor before starting or stopping any drug or supplement routine.

Sources for this article include:

Journals.sagepub.com
Medicalnewstoday.com
NIH.gov
Washingtonpost.com
USpainfoundation.org
Healthline.com
Liverfoundation.org
Eurekalert.org
CNBC.com
Healthfully.com

The Shingles Epidemic

Written by Brenton Wight, LeanMachine – Health Researcher
Updated 20th February 2020

In 1995, the Chicken Pox vaccine was approved, despite warnings from educated immunologists that this would cause an outbreak of shingles!
What happened?
There is now an epidemic of shingles as predicted.
Seniors are more likely to be affected if they have had the Chicken Pox vaccine, but the biggest increase is now seen in  children and young adults after having the Chicken Pox vaccine.
And everyone is now at a higher risk of Shingles, even if they have not had the vaccine, because of the large number of people who had the vaccine can now give Shingles to everyone they contact.
Of course, the CDC has attempted to bury this data because if the public knew the truth, they would no longer trust the very organisation who was entrusted to protect them.
Read more here.

What is Shingles?

People in the 80+ age group are in the highest risk for Shingles. Risk is significant at 60+ and increases every year as we age. Risk doubles by the time we are 70, and increases again in the 80’s.
Although at one time rare to occur in children and teens, Shingles can happen in any age group, but is now occurring more in the young.
Up to 30% of the population can expect an attack at some time in their life, but the risk can be substantially reduced to near zero by using these guidelines.
Shingles is caused by the varicella-zoster (Chickenpox) virus, which is similar, but not quite the same as the herpes virus that causes cold sores and genital herpes, although the treatments listed here such as Lysine are effective against all of these.
People who had Chickenpox as a child are more likely to get Shingles.
The virus can lay dormant in the body for decades, usually sitting in the spinal cord or other nerves, appearing as Shingles often in the 60 to 90 age group after being triggered by a compromised immune system.
Typical triggers are stress, illness, a poor diet, lack of vitamin D3, antibiotic treatments.
The first sign is nerve pain such as burning or tingling sensations along affected nerves. Two to three days later, the virus reaches the skin, and red bumps or blisters develop above the affected nerves. More cases happen in Summer, so heat appears to be a contributing factor.

Symptoms

Nerve tingling or sensitivity is usually the first symptom, followed by painful red blisters along the nerve lines. Often an attack can be felt coming on by neuralgia around the scalp and/or along nerve lines.
Pain can be burning or stabbing, increasing as the condition progresses.
Blister patches can occur anywhere, but most often on the neck or upper trunk, usually only on one side of the torso, or face, arm, or leg. Often flu-like symptoms, chills, or headache accompany the condition.
The pain ranges from very annoying in mild cases, to unbearable in severe cases.
Pain is often reduced when atmospheric pressure is high, and worse when atmospheric pressure is low.

Is Shingles Contagious?

Yes, it can be transmitted by contact to others, even babies and newborns. It is much more likely to be transmitted to others who have never had Chickenpox or never had a vaccination. Regular washing of hands, sheets, pillow cases, towels, and disposal of dressings is essential.
While the risk is not as high as some other diseases, the results can be serious in some cases, so care is always required.

Prognosis

Some people recover well without any treatment in 3 weeks, others suffer for many months or even years. In very severe cases, damage to eyes or brain may develop, causing blindness or hearing loss, but this is very rare. Bell’s Palsy is another possible complication, where one side of the face can become paralyzed.
Usually the younger a patient, the faster the recovery and the milder the symptoms.
Recurrence is rare, but I would suggest permanent use of Lysine as a preventive measure, as this can be a very painful condition.

PHN or postherpetic neuralgia

This is the severe nerve pain associated with Shingles, coming on after the blisters have formed and when the disease is well established. It is much more severe than the original nerve pain when it starts. Pain may be burning, throbbing, or stabbing and can continue long after the blisters have healed.

Shingles Diet

The ratio between Lysine and Arginine is important. We need to increase Lysine and decrease Arginine to treat Shingles.
Arginine is another Amino acid.
Foods containing Lysine include meat, fish, yogurt, milk, eggs, cheese, apples, pears, avocados, apricots, pineapples, green beans, asparagus.
Avoid foods containing Arginine such as tomatoes, wheat germ, brussels sprouts, cashews, peanuts, blackberries, blueberries, grapes, pumpkin seeds, chocolate, sugar, anchovies, tuna, pine nuts and oats.
Just a handful of peanuts for example, contain enough Arginine to cause aggravation of Shingles.
Many weight-loss and body-building products contain arginine, so always check the ingredients.
Of course, many of these Arginine-containing foods are very good for our nutrition, and Arginine has some very beneficial properties, so this diet is only for those with Shingles.
When the Shingles symptoms are gone, we can safely return to a normal diet, as many of the foods listed containing arginine are very good for overall health.
However, I suggest that Lysine supplements be continued for several months, or longer if attacks reoccur.

Foods with Lysine
(Encouraged)
Foods with Arginine
(Avoid)
All meats
Fish
Yogurt
Cheese
Milk
Eggs
Apples
Pears
Apricots
Avocados
Pineapples
Green beans
Asparagus
Tomatoes
Wheat Germ
Brussels sprouts
Cashews
Grapes
Pumpkin Seeds
Pecans
Blackberries
Blueberries
Peanuts
Chocolate
Sugars

Supplements

Two supplements are vital for prevention and recovery, and work well for both Shingles and Chicken pox.

Number one: L-Lysine, an essential amino acid.
L-Lysine (called simply Lysine hereafter) is essential because it must come from the diet or supplements, as the body cannot manufacture it from other components.
Take 1/4 teaspoon dissolved in a glass of water every day as a preventive measure. This product gives over 2 years supply.
To treat Shingles, increase the dose to 1 teaspoon a day until symptoms disappear, then go back to 1/4 teaspoon forever to help prevent a recurrence.
To treat the blisters topically, use Lysine Ointment to apply direct to the affected areas.

Number Two: Vitamin C, very important to build the immune system and reduce nerve pain.
This Vitamin C is pure pharmaceutical grade Ascorbic Acid powder, 453 gram tub. Avoid cheap vitamins made from Sodium Ascorbate which is not the same thing.
Preventive dose is 1/2 teaspoon (2.5 grams) daily.
This can be increased to around 1.5 teaspoons for Shingles treatment, but more may cause loose stools.
See also the IV treatment below.

Other important supplements are:

  • Vitamin D3 to help build the immune system, also to strengthen bones and reduce risk of cancer and other diseases. This is a high dose of 10,000 IU so as a maintenance dose 1 to 3 times a week is fine, but to treat any disease, use daily for 2 to 4 weeks, taken with a meal containing some healthy fat
  • Zinc will also help the immune system
  • Active B12 helps prevent replication of the virus

Note that as we age, we tend to have less Vitamin B-12, Vitamin D3 and Zinc, which is obviously a contributing factor for higher risk of Shingles in seniors.

Herbal Supplements

Herbal supplements can help many conditions, but unfortunately, there are few herbal supplements that have any significant effect on Shingles treatment, but herbs such as
Astragalus can help build the immune system and may help reduce risk of Shingles developing.

Standard Medical Treatment

The Shingles vaccine – Zostavax – Sould I get the jab?

When we start getting old, doctors tell us to get vaccinations for the Flu every year, the Pneumococcal pneumonia vaccine, the Tetanus vaccine every 10 years, and now the Shingles vaccine.
Should we get them all? LeanMachine says no, but this is an individual choice for everyone.
Doctors can give a Shingles vaccine – Zostavax – for prevention, and works for 5 out of 10 people (so the drug manufacturers say), although 3 of every 1000 will get Shingles directly from the vaccination.
In Australia, this is free for the elderly, but will do nothing for an existing condition.
In the USA, the FDA recommends those over 50 get the jab, but the CDC (Centre for Disease Control) says only those over 60.
They all say that we need the jab, whether we have ever had Shingles or not, but this contradicts their own advice that a repeat occurrence is rare.
Zostavax is a live vaccine given in the upper arm as a single injection, and is said to last around five years.
Zostavax, made my Merck, is the same as the Chickenpox vaccine that is given to children, only fourteen times as strong!
Manufacturers claim that the vaccine may reduce the severity and duration of Shingles, but this is what they always say about the flu vaccine. We now know that a glass of water with lemon juice in the morning will also reduce the risk and the severity of the flu, equal to the vaccination in effectiveness. Add some Vitamin D3 and a few other supplements in my upcoming Immunity article, and say bye-bye to the flu.
The worst thing about the Chickenpox vaccination many of us had as children, is that it can cause Shingles, and the Shingles we get from the Chickenpox vaccination is actually far worse than Shingles from a previous Chickenpox infection.

Some side effects of the vaccination

  • Redness, pain, swelling, itching at the injected site
  • A rash similar to Chickenpox
  • Headaches
  • 3 in 1000 will get Shingles directly from the vaccination
  • The Shingles vaccine is only 50% effective at first, dropping to zero effectiveness after 5 years

The vaccine is NOT recommended if:

  • You are allergic to gelatin
  • You are allergic to the antibiotic Neomycin
  • You have a weakened immune system
  • You have HIV/AIDS or any other immuno-supressive disease
  • You are on steroids, Adalimumab (Humira), Infliximab (Remicade), Etanercept (Enbrel)
  • You are on any other immune system suppressing drugs
  • You have received any transplants
  • You are receiving radiation or chemotherapy
  • You have a cancer such as Leukemia or Myeloma that affects the bone marrow
  • You have a cancer such as Lymphoma which affects the lymphatic system
  • You are pregnant or at risk of becoming pregnant

The Shingles Prevention Study

This trial of 39,000 people showed that around HALF the time, the vaccine did NOT protect people against Shingles, a 50% success rate. LeanMachine calls this a 50% failure rate.
That is in the first year.
Successive years had an even higher failure rate, and by year five, failure rate was 100% meaning the vaccine was completely ineffective.
This trial was also carried out by Merck, a drug company with a vested interest in the outcome. When such trials are conducted, results can be misleading. For example, many people drop out of a study, often due to unpleasant or even intolerable side-effects, but all drop-outs are excluded from the results because they did not complete the study. Some people died, and this may have been from cancer, heart attacks or other disease, but who is to know if the vaccine accelerated or delayed their death? No one will ever know as their results are never included because again, they could not complete the study. Many of the results are also distorted because of vaguely-worded questionnaires about side-effects which can be interpreted in different ways. Many drug companies, including Merck, have been taken to court and sued because of deliberate “doctoring” of study results.
However, the study, if we can believe it, showed that the vaccination helped reduce severity of Postherpetic neuralgia, which otherwise in 10% to 15% of patients, continues for some time after the rash disappears, sometimes months, even years. The benefit of vaccination for Postherpetic neuralgia is apparently a 66% or two-thirds success rate in helping to relieve painful symptoms and shortening recovery time. Still not an outstanding success rate (a one-third failure rate), helping tho thirds of about 1 in 8 people who are affected (8%), but for those who have a fear or intolerance of pain, they may consider the jab to be worth the risk, but for those with Shingles already, the vaccination has zero effect on nerve pain. We all know that Vitamin B group helps protect nerves, so this should be added to the Shingles prevention list. No studies have been carried out on Shingles nerve pain with vitamins, but this seems logical to me.

The LeanMachine Study

This is a two-person study (myself plus Mrs LeanMachine) from from early 2010 to 2020, ten years.
Sure, two people is not a significant study as far as the scientific community is concerned.
But for LeanMachine, the improvement in health, the weight loss, the lower blood pressure and triglycerides, the almost elimination of allergies, the extra strength, fitness, energy, and lack of all disease proves to me that no vaccinations are required for anything. Neither of us has had a cold, flu or any other sickness ever since the diet, supplements and lifestyle were all improved at age 63.
Now as I edit this article at age 73, I have still not had even a headache or an upset stomach, so I do not believe I will ever get Shingles, Flu, Tetanus, Pneumonia or anything else.
Check back here in another 27 years to see how I am going!

Alternatives to the Vaccination

As a preventive measure, L-Lysine may be at least just as effective, and possibly much more effective, without any side-effects. After all, Lysine is a natural food and an essential Amino acid which we all need for good health.
Lysine, when combined with Proline, another Amino acid, has been shown to destroy Pancreatic cancer cells, and may well offer some protection against other cancers, and also helps build strong bones.

Intravenous Vitamin C

The amount of Vitamin C that can be taken orally is limited. Most people can take up to around 9000mg (9 grams, or around 4 teaspoons) but higher doses may cause stomach upset. The doctor can organise a much higher dose of Vitamin C using IV (Intra-Venous) drip, typically 50,000mg (50 grams) or more.
The doctor can also prescribe an anti-viral medication such as Acyclovir or Valacyclovir, often (but not always) effective to reduce the time to recover from Shingles, generally more effective in the early stages (first 3 days).
The doctor can also inject a nerve-block anesthetic into the affected nerve to reduce pain, but this wears off after 10 days or so, and does not always work.

What the doctor should NOT do

  • Prescribe painkillers, especially opiates. Painkillers have shown little or no effect for Shingles
  • Prescribe Paracetamol (Acetaminophen or Tylenol in the USA), which destroys glutathione, the “master antioxidant” of the body, impacts liver function and reduces fever. Fever is the body’s mechanism for fighting viruses, so why reduce it?
  • Prescribe anti-depressants. Patients may feel depressed because of pain, but anti-depressant drugs can clobber the immune system, aggravating Shingles
  • Prescribe anti-seizure medication. Can also clobber the immune system, aggravating Shingles
  • Prescribe statin medication, again clobbering the immune system – see below
  • Prescribe antibiotics, which knock out good gut bacteria, our first line of defense for the immune system

If the patient is currently on statin medication (Lipitor, Crestor, Zocor, Simvastatin, etc), they are invariably low on vitamin D3 and Co-Enzyme Q10 and after kicking the doc in the backside, (metaphorically speaking), quit the statins and get some Vitamin D3 and some Co-Enzyme Q10.

Other things to relieve symptoms

  • Take a bath in cool water
  • Use a towel soaked in cool water as a compress to affected areas, but do NOT use ice packs
  • A bath in cool to lukewarm water treated with starch or colloidal oatmeal may help relieve symptoms
  • A cloth soaked with apple cider vinegar applied to the affected areas can help reduce pain and itching
  • A teaspoon of Apple Cider Vinegar daily can help rebuild the gut bacteria and immune system
  • Calamine lotion on affected areas may help relieve symptoms
  • Capsaicin cream (or Red Cayenne Pepper) may help reduce pain when applied to affected areas (keep away from eyes!) but best applied before the blisters open
  • Mix a paste of hydrogen peroxide and baking soda and apply to affected areas and surrounds to help stop spreading. Works best if caught in early stages
  • Peppermint oil applied to the blisters may help
  • A paste made from Epsom Salts (Magnesium Sulfate) and water may help heal blisters
  • Drinking Celery Juice daily may help
  • Spinal manipulation, Reiki, Meditation, and acupuncture may help in some cases
  • Try spraying Colloidal Silver on affected areas. Science says there is no evidence it works, but anecdotal evidence claims it does work
  • To prevent spread or recurrence of infection, wash towels and sheets in the hottest water possible, or at least leave to dry in direct sunlight
  • Wash hands immediately in hot water after touching any affected areas, even more important if there are open blisters

Disclaimer

LeanMachine is not a doctor, and everyone should consult with their own health professional before taking any product to ensure there is no conflict with existing prescription medication.
LeanMachine has been researching nutrition and health since 2010 and has completed many relevant studies.

3 superfood greens that are more nutritious than kale

Reproduced from original article:
https://www.naturalhealth365store.com/3-superfood-greens-healthier-kale
Posted by Jonathan Landsman on 24th January 2020

For a long time now, we’ve all thought kale was the super food in terms of nutrient density – and it wasn’t that easy for a lot of us to make it past that bitter taste, unfortunately.

But did you know that kale actually ranks 15th in terms of nutrient density in a study recently published by the CDC titled Defining Powerhouse Fruits and Vegetables (PFV): A Nutrient Density Approach?  You can find a link to that report below, so that you can read all about the 41 fruits and vegetables that the CDC found to be nutrient powerhouses.

Let’s look at the top 3 “super food” greens that rank higher than kale.

Watercress (nutrient density score of 100) 

 Watercress might look like a more delicate smallish leaves, but watercress is actually a relative of horseradish and mustard greens and it tastes very peppery, indeed.

 Watercress is a member of the cruciferous vegetable family, alongside nutritious vegetables like Brussel’s sprouts, kale, arugula, and broccoli. Plus, it’s packed with so much nutrition it might just qualify as the super food of the decade.

Ranking at 100 in terms of nutrient-density, just one cup of watercress gives you 106% of your vitamin K requirement, and around a fourth of your RDA for vitamins A and C.

Watercress is also a great source of fiber, potassium, protein, calcium, and magnesium and it’s jam-packed with antioxidants and phytonutrients that can protect you against oxidative damage in the form of free radicals, which are associated with aging, cancer, and many other debilitating diseases like Alzhiemer’s.

Scientists have also found that eating watercress daily can reduce DNA damage to blood cells, which is considered to be the hallmark event that triggers the development of cancer. The same study revealed that eating watercress daily improved blood levels of lutein (by 100%) and beta-carotene (by 33%) – 2 phytonutrients which are very protective of the eyes, preventing macular degeneration and cataracts.

 Try adding watercress to your salads, pairing it with mild but equally nutritious greens like green leaf lettuce or Bibb lettuce!

Chinese or Napa cabbage (nutrient density score of 91.99)

Napa cabbage is another cruciferous vegetable that is jam-packed with nutrition. Napa cabbage provides 85% of your RDA for vitamin K and over half your RDA for vitamin C.

It’s also rich in nutrients like folate, hard-to-get manganese, and vitamin B6 as well. Cabbage was voted one of two vegetables which can help prevent diabetes (the other being root vegetables). Being a cruciferous vegetable, it’s also proven to help reduce blood markers for inflammation.

Like watercress, Chinese or Napa cabbage is packed with antioxidants and phytonutrients and is currently being researched for its cancer-fighting benefits. One study of Chinese women found that consumption of brassica vegetables like Chinese cabbage helped to significantly reduce breast cancer risk.

Swiss chard (nutrient density score of 89.27) 

 A nutrient-dense powerhouse, Swiss chard contains 44% of your RDA for vitamin A, 18% of your RDA or vitamin C, and a whopping 374% of your RDA for vitamin K.

Swiss chard is loaded with antioxidants and phytonutrients, including a potent flavonoid called syringic acid, which aids the liver in detoxifying the body, and which helps lower liver enzymes and prevent liver degeneration as well.

Swiss chard is also rich in powerful antioxidants called betalains, which have powerful antioxidant and detoxification properties by supporting the phase II pathways of the liver.

Because it’s so packed with vitamin K, yielding over 3 times your RDA for this nutrient, Swiss chard can help lower blood cytokines, which raise your risk for inflammation and inflammation-based diseases, especially type 2 diabetes.

Editor’s note: The NaturalHealth365 Store offers the finest quality nutritional supplements to support a healthy lifestyle.  Click here to shop today!

Sources for this article include:

CDC.gov

NIH.gov

NIH.gov

NIH.gov

NIH.gov

NIH.gov

Farm raised fish: The “untold” health risk exposed

Reproduced from original article:
www.naturalhealth365.com/farm-raised-fish-fatty-liver-3282.html

by:  

farm-raised-fish

(NaturalHealth365) Head to the seafood counter at your local grocery store and you’re faced with a big choice: farm raised fish or wild caught fish.

You already know that certain types of fish, such as salmon, offer many health benefits. But, there are also the stories of health risks and contaminants that surround certain types of fish.  And, while eating fish is often considered a healthy option, that’s not always true – especially if you don’t pay attention to the type of fish you take home from the store.

While shopper demand for tasty fish remains high, some of the world’s fish stocks continue to decline.  So, some “experts” claim to have the answer: farmed fish.  But is this really a healthy and safe choice?

One recent study discovered that farm raised fish have a fatty liver, leading to multiple negative health consequences and caused from a variety of factors we should find concerning.

Fatty liver in farm raised fish results in negative health consequences

According to researchers, fatty liver has become very common in fish raised on farms. When fish have a fatty liver, it reduces growth and can reduce their nutritional quality when we eat them, and even impair their immune response.

Although scientists haven’t figured out one definitive cause of fatty liver in farm raised fish, one of the biggest contributors is likely the unbalanced nutrition and excess energy intake that occurs as a result of overfeeding, foods deficient in essential vitamins, and a diet that includes excess carbohydrates and dietary fats.

Do NOT ignore the health dangers linked to toxic indoor air.  These chemicals – the ‘off-gassing’ of paints, mattresses, carpets and other home/office building materials – increase your risk of headaches, dementia, heart disease and cancer.

Get the BEST indoor air purification system – at the LOWEST price, exclusively for NaturalHealth365 readers.  I, personally use this system in my home AND office.  Click HERE to order now – before the sale ends.

Researchers believe that one way to reduce the problem with fatty liver among farm raised fish is to focus on feeding them a more nutrient-balanced diet, keeping the water environment healthy, and ensuring the feed given these fish is fresh.

Additional health risks to eating the wrong kind of fish

Of course, beyond this new information showing that farm raised fish often have fatty liver, there’s plenty of other research that shows additional health risk to eating farm raised instead of wild caught fish.

One of the key differences between farm raised and wild caught fish is their nutrition. Wild caught fish usually has fewer calories and lower fat content than farmed fish.

When you eat this kind of commercially-produced fish, you have a risk of being exposed to persistent organic pollutants, which are found to be 5-10 times higher in farmed fish and have been linked to diseases like obesity and type 2 diabetes.

In addition, due to crowded conditions, farmed fish are pumped with antibiotics to keep disease away.

Unfortunately, eating large quantities of fish and meat packed with antibiotics contribute to diseases becoming antibiotic resistant. Studies have also shown that the contaminant levels in farmed salmon are higher than in wild caught salmon – which means that farm raised fish is likely to be higher in contaminants while wild caught options are considered to be safer overall.

No doubt, wild caught fish offers a more nutritious, safer option when you’re trying to add more fish to your diet. So next time you’re in the store picking out fish for dinner, skip the farmed fish and pay a little extra for the healthier, wild caught fish.

Sources for this article include:

CNKI.com.cn
ClevelandClinic.org

Candida

Written by Brenton Wight, Health Researcher, LeanMachine
Copyright © Brenton Wight, LeanMachine
Updated 31st January 2020

Candida albicans, also known as Yeast infections, Fungal infections, Mycosis and Thrush

Almost everyone has Candida in their bodies. For most of us, it causes no problems.
But if our immune system is compromised by antibiotics, poor diet, sleep deprivation or other factors, candida can grow uncontrollably.
Each of us has about 70 to 100 or more trillion bacteria in our bodies, weighing between 1 and 2kg, or over 3% of our total body weight.
Most of them good, but some are bad – really bad, like yeast, parasites and other organisms, and most of the time we don’t know they are even there.
If we are healthy with a good diet, our immune system and the good bugs keeps the bad bugs under control. We can never eliminate them, but we can keep them at levels where they can’t do too much harm.
75% of our immune system is in the gut – our trillions of good bacteria is our second, but most important line of defence against unwelcome invaders.
Our first line of defence is in the mouth, and this is where our good bacteria first start to knock out the bad guys, and this is why sugar should be banned from our diet, as sugar keeps the bad bugs fed well.
Healthy gut flora keeps candida under control, because in it’s normal state, Candida is a relatively weak fungal type bug.
Unfortunately, under some conditions, Candida can transform into dangerous mutations, changing to an aggressive bug which can cause systemic (throughout the entire body) destruction.
Candida is very common, and very dangerous.
75% of women, and many men, suffer from Candida in some form at some stage, from minor symptoms including rashes, increased PMS issues and bad breath, to severe conditions like IBS (irritable bowel syndrome), depression, joint pain, and chronic fatigue syndrome.
A Candida problem can be a host of apparently unrelated chronic symptoms which refuse to go away, regardless of treatments, and a course of antibiotics only makes things much worse.

Mainstream Medicine Mistakes

In the 1980’s links were found between candida, chronic fatigue, chronic pain problems and fibromyalgia-type symptoms.
Mainstream health professionals have little idea how to diagnose, let alone treat Candida issues, and those who do attempt to treat Candida use dangerous medications which often exacerbate the situation by destroying our good bacteria, leaving us defenseless against the bad guys.
Creams, oils, lotions, etc are only marginally effective on the skin where applied, and cannot resolve systemic, body-wide infestations.
The “nuke it” approach, with powerful anti-fungal prescription medications, can work temporarily, but Candida is smart enough to disguise itself and eventually develop resistance to the medication.
Drugs used for other purposes such as antibiotics, cortisone therapy, immune-suppressants, even birth control pills can start a Candida infestation explosion.
Candida critters are very smart.
Classified as a fungus, but are in fact part plant, part animal, part bacteria, part parasite, and able to reproduce themselves either sexually (with a mate) or asexually (by themselves), and by re-arranging their own chromosomes, can alter their shape and forms to adapt to the environment and ensure survival.
No surprise that with these attributes, it can be very difficult to dispose of yeast infections!

How Candida Works

In the normal, relatively harmless yeast form, under the microscope, Candida looks like a small white egg, with a smooth and consistent shape and living in our gut.
Candida feeds on the food we eat and normally keeps to itself, but under some conditions, it mutates into a monster super-fungus, multiplying rapidly to colonise in every possible part of the body.
In some areas it can double the colony size every hour, so before long it runs rampant, destroying everything in it’s path.
The best way to start this happening is to feed it it’s favourite food – sugar!

Candida Symptoms

  • White coating on the tongue
  • Development of food sensitivities
  • Aches and pains without a known cause
  • Bloating, constipation or diarrhea
  • Persistent fatigue
  • Dry or other skin problems
  • Vaginitis (inflammation of the female genital area)
  • Breathing problems

Mutated Forms

The mutated form called mycelial-form of Candida grows rhixoids, which are elongated, finger-like tentacles that tunnel, bore and burrow their way through our gut walls, where they enter the blood vessels, to be transported everywhere in the body, blooming to a systemic infection.
They now appear anywhere – heart, eyes, kidneys, liver, lungs and even the brain. A yeast infection is not just a minor annoyance causing a little itching – this is a warning sign that some insidious thing is happening.
Like tree roots which can crack, lift and eventually destroy pavement, Candida does the same thing to our bodies as it mutates into the dangerous super-fungus form. Apart from entering the blood through the cracks in our gut and spreading, another opportunity is now “opened up” – many other undesirable things now enter our blood stream through these cracks; things which should normally stay in our gut: Bacteria, toxins, undigested food, milk, etc.

A short note about Milk

This is a good reason why no-one should ever drink homogenised milk, as the fat globules in homogenised milk are ten times smaller than un-homogenised milk, easily entering the blood through the tiniest holes in the gut.
When undigested milk enters the bloodstream directly through a “leaky gut”, the body’s own immune system recognises this as a unwanted invader and attempts to destroy it. From that time on, the immune system remembers this pattern, and we then have a milk allergy.
Leaky gut is the main culprit for the rapid rise in allergies we have seen in the last few decades, as we are now allergic to every food that passes directly into the blood.
We can find unhomogenised milk at all good supermarkets if we look hard enough, but none of the major brands make it.
Sure we have to shake the container to mix the cream, but that is a small price to pay for our better health, and I should also mention that we should never buy low-fat or skim milk, as all of the nutrients, including CLA (Conjugated Linoleic Acid) and Omega-7, have been lost with the cream.
The “Low Fat” advertising is a gimmick. We lose weight more effectively with full-cream milk compared to low-fat milk.
Milk also contains lactose. Like most other things ending in “ose”, lactose is a sugar, and sugar feeds candida (and cancers).
Again, milk fills a complete chapter in my upcoming book, so I’ll leave a summary: Most people do better without milk, have less allergies without milk, lose more weight without milk, have stronger bones without milk, but if you have to have milk, FULL-CREAM and UN-HOMOGENISED milk is the only reasonably healthy milk to buy, and if you can get it straight from the cow (NON-PASTEURISED), even better.

Candida Waste Products

Candida overgrowth can make us feel sick, tired, plain lousy, and can make us drunk from inside out!
As yeast dies as part of it’s natural life cycle, acetaldehyde is released. This is a toxin which the liver converts to ethanol, the same hangover-causing chemical produced by high consumption of alcohol, so Candida sufferers often feel like they have a hangover without drinking a drop of alcohol, because they have an alcohol factory in their own body.
Another problem, as if we don’t have enough problems already, is “Candida Poo”, which is the 79 distinct toxins and waste by-products released as part of the Candida lifecycle. It’s bad enough that we feed all parasites, but we have to clean up and dispose of their waste and toxic elements as well as recover from the damage and disease they cause!
Candida infestation can continue growing, producing more acetaldehyde, causing our blood alcohol level to rise enough to cause symptoms such as impaired thinking, lack of concentration, irritability, depression, brain fog, slowed reflexes, fatigue and other signs of excess alcohol.
In this state, red blood cells have trouble flowing into small capillaries, aggravating migraine headaches, fatigue, muscle aches, slowing healing.
At the same time, white blood cells have reduced ability to fight infection, often causing allergies, rashes, acne and even further inhibiting of healing processes.
Like the way bread rises from yeast because of carbon dioxide released from carbohydrate fermentation, Candida builds up carbon dioxide in the intestine, resulting in excess gas, bloating, and yet another waste product for the over-taxed body to dispose of.

The Real Candida Cause

Can we defeat this little terror? Of course we can, but we must get back to basics to eliminate problems once and for all.
Why do we get Candida in the first place? Everyone has Candida, because we can’t help consuming it from food, water and the environment, but the reason it develops is because our body gets out of balance, and our immune system gets compromised, allowing immediate, almost uncontrollable flourishing of Candida.
We cannot destroy Candida completely without killing ourselves, so our only real, long-lasting solution is to re-balance the body, restore the immune system, and let the body’s own natural defenses do their job.
If we have bad breath, rashes, fatigue, trouble concentrating, brain fog, strange allergies, weird pains or anything we can’t explain, it could be a sign that something is out of whack, allowing Candida to get out of control, and even if the problem is not Candida, correcting the balance and immune system of the body is the first step to recovery from any sickness.

Candida and Cancer

New research is now finding a link between Candida infections and Cancer. While billions of dollars are being spent on cancer research, cancer cases are increasing, now overtaking cardiovascular issues as a leading cause of death. LeanMachine suggests that staying Candida free is the first step in staying Cancer free. Like most modern diseases, prevention is the key, then requiring no cure.

The Cure

We must create an environment which is good for nourishment of the body, but bad for Candida. By following these guidelines, we will remain Candida free, and also reduce the risk of Cancer, Diabetes, Alzheimer’s, and most other “modern” diseases.

  • Eliminate all sugar from the diet. The natural sweetener Xylitol is OK as it is a 5-carbon sugar alcohol, and despite it’s misleading name (it is technically neither a sugar, nor an alcohol), it will not feed Candida, and has far less insulin-spiking effect. Other alternatives are Erythritol and Stevia, with virtually zero insulin spiking. Avoid all artificial sweeteners. In the long term, lose the sweet-tooth altogether
  • Change to an alkaline-forming diet, as acids cause Candida and other parasites to thrive. See my Alkaline Diet Article
  • Avoid yeast in all forms. All grain/flour based products will acidify and aggravate our bodies, and are usually made with yeast, the best food for Candida. No more bread, cakes, biscuits, muffins, etc. Tough for some people but you will thank me a few weeks! Excess weight will slowly disappear, while digestion, health and energy will all improve, and the holes in the gut caused by flour products will begin to heal
  • Keep cool and dry, wear well-ventilated clothing and live in a well-ventilated house. Candida loves sugar, warmth and moisture. Avoid artificial fibres in clothing. Keep to natural fibres like cotton, bamboo or wool. Before buying any clothing, give it a sniff. Any trace of a chemical smell? Leave it in the store
  • Never take antibiotics unless there is a severe, life-threatening situation. Antibiotics encourage Candida and other harmful organisms by destroying their natural enemies (the good bacteria)
  • Reduce carbohydrate intake, as all carbs feed Candida. This means potatoes, pasta, grains, cereals, breads, cakes, etc. A healthy body requires NONE of these “foods”. There is NO medical condition such as “Carbohydrate Deficiency” as the body can make all the carbs it needs from breaking down protein
  • Take liver detox supplements such as Milk Thistle
  • Add some parsley to each meal. Easy to grow yourself in a pot, and available at the greengrocer or supermarket
  • Take a supplement containing Pau D’Arco or Candida Support
  • The main ingredient in Pau d’Arco is beta-lapachone, also a potent catalyst for NADH (Reduced Nicotinamide Adenine Dinucleotide, or NAD+ or CoEnzyme E1), important for mitochondria, the energy components of every cell in the body and as a sensor for stress and disease
  • Also consider Pumpkin Seed Oil for more parasite protection
  • Most kitchens have cloves in the spice rack. Add them to everything to help control Candida and other parasites, and add a great flavour at the same time
  • Berberine has anti-inflammatory, immune-enhancing, anti-microbial properties against bacteria, protozoa, and fungi. Berberine’s action against Candida pathogens is stronger than prescription antibiotics commonly used
  • Echinacea is also of benefit in building the immune system
  • Aloe contains a mucopolysaccharide with strong immune properties and also benefits the mitochondria
  • Take a probiotic supplement such as Acidophilus or at least eat some yogurt every day to help re-build the good gut flora
  • Try to use a probiotic that includes a FOS (fructo-oligosaccharides), a pre-biotic that enhances functionality of gut flora, included in Acidophilus above
  • Fermented foods – sauerkraut, etc are a good source of probiotics, generally much more than available in supplements
  • Eat more high-fibre foods like chia seeds, preferably containing over 40 grams of fibre daily
  • Or take a daily fibre supplement containing Psyllium to improve regularity, keep things moving through the colon, improve internal cleansing and reduce risk of colon cancer. Can help relieve constipation, but because it increases bulk with both soluble and insoluble fibre, may also help with diarrhoea
  • Eat some garlic every day, or at least onions or shallots, but if the taste and odour is not to your liking, then try Odorless Garlic
  • To help cleanse the blood and the liver, eat Chlorophyll-rich foods (Green leafy vegetables) every day, or take Chlorophyll supplements. The molecular structure of Chlorophyll and Haemoglobin appear identical, apart from one small difference: Haemoglobin has a central iron atom (making blood red), while Chlorophyll has a central magnesium atom (making plants green)
  • Coconut Oil contains Caprylic Acid, along with capric acid and lauric acid, MCT (Medium Chain Triglycerides) that help defeat candida as it is a natural anti-fungal, anti-viral and anti-bacterial product, and also helps lose weight, as MCT’s go straight to the liver to be burned as fuel and cannot be stored as fat
  • Avoid antibiotics, steroid hormones and oral contraceptives, as they alter the gut bacteria, increasing risk of candida changing into an invasive form
  • Avoid antibiotics in food such as from animals raised in concentrated animal feeding operations which are fed antibiotics to counteract bad sanitation and to boost growth. Ask for “grass fed” or “pasture raised” meat, and limit meat consumption (acidic) in favour of plant foods (alkaline)
  • Get more good sleep, more exercise and an alkaline, sugar-free diet, but never consume food or drink with aspartame or other artificial sweeteners, which destroy good gut bacteria. Stevia is a better natural choice and has anti-cancer properties
  • Treat the partners of infected patients, even if there are no symptoms, as they can also be carrying abnormally large amounts of Candida, potentially leading to constant cross-infections
  • Continue treatment until all symptoms have disappeared, plus a further 2 weeks, which destroys eggs laid by the previous generation

Drug Therapy

There are some prescription drugs which can help if all of the above fails and the condition is serious:

  • Nystatin, an antifungal, available as tablets or a powder, and fairly benign with few side effects.
  • Diflucan, an antibiotic if all else fails

LeanMachine Online Supplements: Health Supplements

Updated: 31st January 2020.   Copyright © 1999-2020 Brenton Wight – Lean Machine

More Health Benefits of Quercetin Revealed


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2020/01/27/quercetin-benefits.aspx
Analysis by Dr. Joseph Mercola     Fact Checked image

January 27, 2020
quercetin benefits

STORY AT-A-GLANCE

  • Quercetin has been shown to combat inflammation and acts as a natural antihistamine. Several studies have highlighted quercetin’s ability to prevent and treat both the common cold and influenza
  • Another, less known benefit and use for quercetin includes the prevention and/or treatment of high blood pressure, cardiovascular disease, metabolic syndrome, certain cancers, gout, arthritis and mood disorders
  • A review of quercetin’s effect on metabolic syndrome found it significantly reduced fasting plasma glucose when taken for at least eight weeks at a dosage of 500 milligrams per day or more
  • Other recent research found quercetin has a beneficial impact on nonalcoholic fatty liver disease by ameliorating inflammation, oxidative stress and lipid metabolism
  • Quercetin also has the ability to trigger tumor regression by interacting with your DNA and activating the mitochondrial pathway of apoptosis (the programmed cell death of damaged cells)

Quercetin1 is an antioxidant flavonol found naturally in foods such as apples, plums, red grapes, green tea, elder flower and onions, just to name a few.2 According to a 2019 Market Watch report,3 the quercetin market is growing rapidly as its health benefits are becoming more widely known.

Quercetin has been shown to combat inflammation and acts as a natural antihistamine. In fact, its antiviral capacity appears to be the primary focus of many studies looking at quercetin’s benefits, and a number of studies have highlighted quercetin’s ability to prevent and treat both the common cold and influenza.4,5,6,7

But there are also other, less known benefits and uses for this supplement, including the prevention and/or treatment of:8

High blood pressure9 Cardiovascular disease10
Metabolic syndrome11 Certain kinds of cancer12
Nonalcoholic fatty liver disease (NAFLD)13 Gout14
Arthritis15 Mood disorders16
Longevity, thanks to its senolytic benefits (clearing out damaged and worn-out cells)17,18

Additionally, quercetin is also helpful for aluminum-induced neurodegenerative changes, such as those seen in Alzheimer’s, Parkinson’s and amyotrophic lateral sclerosis (ALS). As noted in a 2016 study:19

“Administration of quercetin (10 mg/kg body wt/day) reduced aluminum (10 mg/kg body wt/day)-induced oxidative stress (decreased ROS production, increased mitochondrial superoxide dismutase (MnSOD) activity).

In addition, quercetin also prevents aluminum-induced translocation of cyt-c, and up-regulates Bcl-2, down-regulates Bax, p53, caspase-3 activation and reduces DNA fragmentation …

Further electron microscopic studies revealed that quercetin attenuates aluminum-induced mitochondrial swelling, loss of cristae and chromatin condensation. These results indicate that treatment with quercetin may represent a therapeutic strategy to attenuate the neuronal death against aluminum-induced neurodegeneration.”

Quercetin Improves Metabolic Syndrome Traits

Among the most recent papers on this powerful antioxidant is a review20 published in the March 2019 issue of Phytotherapy Research, which looked at nine randomized controlled trials investigating quercetin’s effect on metabolic syndrome.

Metabolic syndrome refers to a cluster of conditions (including high blood pressure, high blood sugar, high triglyceride levels and fat accumulation around the waist) that raise your risk for Type 2 diabetes, heart disease and stroke.

While pooled findings found no effect on fasting plasma glucose, insulin resistance or hemoglobin A1c levels, further subgroup analyses revealed quercetin supplementation “significantly reduced” fasting plasma glucose in studies lasting at least eight weeks and in which dosages of at least 500 milligrams (mg) per day were used.

In studies that included people over the age of 45, “significant” reductions in insulin were also found when using a dosage of 500 mg per day or more. An earlier study,21 published in 2011, looked at quercetin’s effects on certain traits of metabolic syndrome.

This study focused specifically atherosclerosis and inflammation in men with the APOE genotype 3/3, 3/4 and 4/4, and found quercetin significantly decreased waist circumference, postprandial systolic blood pressure, postprandial triacylglycerol, and increased HDL-cholesterol compared to placebo. Here, participants were given 150 mg of quercetin per day for eight weeks.

Research22 on obese rats published in 2008 also found that quercetin supplementation at doses of 2 mg per kilo or 10 mg/kg of body weight for 10 weeks improved systolic blood pressure, triglyceride, total cholesterol and free fatty acid levels. The 10 mg/kg dose also improved the animals’ inflammation status. As noted by the authors:

“In conclusion, both doses of quercetin improved dyslipidemia, hypertension, and hyperinsulinemia in obese Zucker rats, but only the high dose produced antiinflammatory effects in VAT together with a reduction in body weight gain.”

One of the first studies23 to demonstrate quercetin’s beneficial effects on blood pressure was published in 2007. As reported by the authors:

“Epidemiological studies report that quercetin … is associated with reduced risk of coronary heart disease and stroke … Men and women with prehypertension and stage 1 hypertension were enrolled in a randomized, double-blind, placebo-controlled, crossover study to test the efficacy of 730 mg quercetin/d for 28 d[ays] vs. placebo.

Blood pressure at enrollment was … 148 +/- 2/96 +/- 1 in stage 1 hypertensive subjects … Reductions in systolic (-7 +/- 2 mm Hg), diastolic (-5 +/- 2 mm Hg), and mean arterial pressures (-5 +/- 2 mm Hg) were observed in stage 1 hypertensive patients after quercetin treatment … These data are the first to our knowledge to show that quercetin supplementation reduces blood pressure in hypertensive subjects.”

Similarly, a January 2020 systematic review24 of 17 studies concluded quercetin “significantly decreased” blood pressure in human subjects. Those who took it for eight weeks or more also had “significantly” improved high-density lipoprotein cholesterol and triglycerides.

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Quercetin Improves Diabetes-Induced NAFLD

Other recent research25 published in the August 2019 issue of Phytotherapy Research concluded quercetin has a beneficial impact on NAFLD “by ameliorating inflammation, oxidative stress and lipid metabolism.”

Diabetes can play a role in NAFLD as well, showing just how influential insulin resistance is in the development of chronic diseases of all kinds. As explained in the abstract:

“Multiphase pathological processes involve in Type 2 diabetes (T2DM)‐induced nonalcoholic fatty liver disease (NAFLD). However, the therapies are quite limited. In the present study, the hepatoprotective effects and underlying mechanisms of quercetin in T2DM‐induced NAFLD were investigated …

The results revealed that quercetin alleviated serum transaminase levels and markedly reduced T2DM‐induced histological alterations of livers. Additionally, quercetin restored superoxide dismutase, catalase, and glutathione content in livers.

Not only that, quercetin markedly attenuated T2DM‐induced production of interleukin 1 beta, interleukin 6, and TNF‐α. Accompanied by the restoration of the increased serum total bile acid and the decreased liver total bile acid, quercetin could reduce lipid accumulation in the liver … These findings suggested that quercetin might be a potentially effective drug for the treatment of T2DM‐induced NAFLD.”

Quercetin Helps Modulate Gene Expression

According to research26 published in 2016, quercetin even has the ability to trigger tumor regression by interacting with your DNA and activating the mitochondrial pathway of apoptosis (the programmed cell death of damaged cells).

Quercetin was found to induce cytotoxicity in leukemic cells, and the effect was dose-dependent. Limited cytotoxic effects were also found in breast cancer cells. Overall, quercetin increased the life span in cancer-ridden mice fivefold compared to untreated controls.

The authors attributed these effects to quercetin’s direct interaction with DNA and its activation of the mitochondrial pathway of apoptosis, and suggested quercetin’s potential use as a cancer therapy adjunct deserves further exploration.

More recent research27 in the journal Molecules also highlights quercetin’s epigenetic influence and ability to:

  • Interact with cell-signaling pathways
  • Modulate gene expression
  • Influence the activity of transcription factors
  • Modulate microRNAs

MicroRNAs used to be considered “junk” DNA. Far from being useless, research has now revealed that “junk” DNA is actually microRNA and plays a crucial role in regulating genes that make the proteins that build your body.

The microRNA function as “on/off” switches for the genes. Depending on the microRNA input, a single gene can code for any of more than 200 protein products. Quercetin’s ability to module microRNA may also help explain its cytotoxic effects, and why it appears to improve cancer survival (at least in mice).

Quercetin Is a Powerful Antiviral

As mentioned, one of the most well-studied attributes of quercetin is its antiviral capacity, which have been attributed to three main mechanisms of action:

  1. Inhibiting the virus’ ability to infect cells
  2. Inhibiting replication of already infected cells
  3. Reducing infected cells’ resistance to treatment with antiviral medication

For example, research28 funded by the U.S. Department of Defense, published in 2007, found it lowers your risk of viral illness and boosts mental performance following extreme physical stress, which might otherwise undermine your immune function and render you more susceptible to infections.

Here, cyclists who received a daily dose of 1,000 mg of quercetin in combination with vitamin C (which enhances plasma quercetin levels29,30) and niacin (to improve absorption) for five weeks were significantly less likely to contract a viral illness after bicycling three hours a day for three consecutive days, compared to untreated controls. While 45% of the placebo group got sick, only 5% of the treatment group did.

In another study31 funded by the U.S. Defense Advanced Research Projects Agency (DARPA), published in 2008, animals treated with quercetin were challenged with a highly pathogenic H1N1 influenza virus. Again, the treatment group had significantly lower morbidity and mortality than the placebo group. A number of other studies have also confirmed quercetin’s effectiveness against a variety of viruses, including the following:

A 1985 study found quercetin inhibits infectivity and replication of herpes simplex virus type 1, polio-virus type 1, parainfluenza virus type 3 and respiratory syncytial virus.32
A 2010 animal study found that quercetin inhibits both influenza A and B viruses. Two other important discoveries were made. Firstly, the viruses were unable to develop resistance to quercetin, and secondly, when used concomitant with antiviral drugs (amantadine or oseltamivir), the effect was significantly amplified — and it prevented drug-resistance from developing.33
A 2004 animal study investigating quercetin’s effect on influenza used a strain of the H3N2 virus. According to the authors:34

“During influenza virus infection, there is ‘oxidative stress.’ Because quercetin restored the concentrations of many antioxidants, it is proposed that it may be useful as a drug in protecting the lung from the deleterious effects of oxygen derived free radicals released during influenza virus infection.”

Another 2016 study found quercetin offered protection against influenza A virus H1N1 by modulating protein expression. More specifically, the regulation of heat shock proteins, fibronectin 1 and prohibitin was instrumental in reducing viral replication.35
A third study published in 2016 found quercetin inhibited a wide spectrum of influenza strains, including H1N1, H3N2 and H5N1. According to the authors, “This study indicates that quercetin showing inhibitory activity in the early stage of influenza infection provides a future therapeutic option to develop effective, safe and affordable natural products for the treatment and prophylaxis of [influenza A viruses] infections.”36
In 2014, researchers noted that quercetin appears to be “a promising treatment for the common cold,” caused by the rhinovirus, adding that “Quercetin has been shown to reduce viral internalization and replication in vitro, and viral load, lung inflammation and airways hyper-responsiveness in vivo.”37

By attenuating oxidative damage, it also lowers your risk of secondary bacterial infections, which is actually the primary cause of influenza-related deaths. Importantly, quercetin increases mitochondrial biogenesis in skeletal muscle, which suggests part of its antiviral effects are due to enhanced mitochondrial antiviral signaling.

A 2016 animal study38 found quercetin inhibited mouse dengue virus and hepatitis virus. Other studies have confirmed quercetin’s power to inhibit both hepatitis B39 and C40 infection.
Most recently, a March 2020 study41 in the Microbial Pathogenesis journal found quercetin “provides comprehensive protection against Streptococcus pneumoniae infection,” both in vitro and in vivo, primarily by neutralizing pneumolysin (PLY),42 one of the toxins released from pneumococci that encourages S. pneumoniae infection to blossom in the first place. As reported by the authors in Microbial Pathogenesis:

“The results indicated that quercetin significantly reduced PLY-induced hemolytic activity and cytotoxicity via repressing the formation of oligomers.

In addition, treatment with quercetin can reduce PLY-mediated cell injury, improve the survival rate of mice infected with a lethal dose of S. pneumoniae, alleviate the pathological damage of lung tissue and inhibit the release of cytokines (IL-1β and TNF-α) in bronchoalveolar lavage fluid.

Considering the importance of these events in antimicrobial resistant S. pneumoniae pathogenesis, our results indicated that quercetin may be a novel potential drug candidate for the treatment of clinical pneumococcal infections.”

Quercetin Combats Inflammation and Boosts Immunity

Aside from its antiviral activity, quercetin is also known for boosting immunity and combating inflammation. As noted in a 2016 study43 in the journal Nutrients, mechanisms of action include (but is not limited to) the inhibition of:44

Lipopolysaccharide (LPS)-induced tumor necrosis factor α (TNF-α) production in macrophages. TNF-α is a cytokine involved in systemic inflammation, secreted by activated macrophages, a type of immune cell that digests foreign substances, microbes and other harmful or damaged components

LPS-induced mRNA levels of TNF-α and interleukin (IL)-1α in glial cells, which results in “diminished apoptotic neuronal cell death”

The production of inflammation-producing enzymes

Calcium influx into the cell, which in turn inhibits:

Pro-inflammatory cytokine release

Histamine and serotonin release from intestinal mast cells release45

According to this paper, quercetin also stabilizes mast cells, has cytoprotective activity in the gastrointestinal tract, and “a direct regulatory effect on basic functional properties of immune cells,” which allows it to inhibit “a huge panoply of molecular targets in the micromolar concentration range, either by down-regulating or suppressing many inflammatory pathways and functions.”46

Quercetin May Be a Useful Supplement for Many

Considering its wide-ranging benefits, quercetin may be a useful supplement for many, either acutely or more long-term. It’s one of the supplements I recommend keeping in your medicine chest for times when you feel you’re “coming down” with something, be it the common cold or influenza.

If you’re prone to colds and flu, you could consider taking it for a couple of months before cold and flu season hits to boost your immune system. More long-term, it appears useful for those with metabolic syndrome, although it would be foolish to rely on any given supplement without also addressing more fundamental strategies such as diet and exercise.

As explained in my 2015 interview with Dr. Robert Lustig, sugar has been shown to be a causative factor in insulin resistance, which is a hallmark of metabolic syndrome and a risk factor for virtually all chronic disease.

If you have one or more of the conditions that make up metabolic syndrome, you’d be wise to limit your total sugar consumption to 15 grams per day. If you’re healthy, and want to stay that way, your daily sugar limit would be around 25 grams. You can learn more about this and related treatment strategies in “Vitamin D Can Significantly Lower Your Risk of Metabolic Syndrome.”

– Sources and References

Iron Overload Destroys Mitochondria and Sabotages Health


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2020/01/15/iron-overload-destroys-mitochondria.aspx

Analysis by Dr. Joseph Mercola Fact Checked image
January 15, 2020
iron overload destroys mitochondria

STORY AT-A-GLANCE

  • Iron is essential for life as it transfers oxygen to your tissues. Hemoglobin, the protein in your red blood cells, contains iron at its core, which reversibly binds to oxygen and supplies your tissues with it
  • Without proper oxygenation, your cells quickly start dying. However, excess iron can also cause severe problems by encouraging oxidation and tissue damage
  • Common health problems associated with elevated iron levels include cirrhosis, cancer, hepatitis C, gouty arthritis, arrhythmia, cardiovascular disease, Type 2 diabetes, Alzheimer’s and more
  • Recent research shows excessive iron damages mitochondrial function and impairs your heart function by inducing the death of muscle cells in your heart
  • Your iron level can be easily determined with a serum ferritin test. I believe this is one of the most important tests that everyone should have done on a regular basis as part of a preventive, proactive health screen

Iron is necessary for life as it essential to transfer oxygen into your tissues. Hemoglobin, the protein in your red blood cells that contains iron at its core, reversibly binds to oxygen and supplies your tissues with it. Without proper oxygenation, your cells quickly start dying.

Iron is also a key component of various proteins and enzymes, and is involved in energy production, immune function, metabolism and endocrine function. For these reasons, low iron (anemia) can cause significant health problems.

However, what many don’t realize is that excess iron is actually more common than too little, and iron overload can be even more problematic, as detailed in “Why Managing Your Iron Level Is Crucial to Your Health,” which features my interview with Gerry Koenig, former chairman of the Iron Disorders Institute and the Hemochromatosis Foundation.

Because your body has a limited capacity to excrete iron, it can easily build up in organs like your liver, heart and pancreas. This is dangerous because iron is a potent oxidizer that can damage your tissues and contribute to a variety of health problems, including but not limited to:

Cirrhosis1 Cancer, including bowel,2 liver3 and lung cancer4 — Elevated ferritin is associated with a 2.9 times higher risk of death from cancer5 and blood donors have been shown to have a lower likelihood of developing certain cancers than nondonors6,7
Hepatitis C8 — As noted in a 2007 paper,9 even “mild or moderate increase of iron stores appears to have significant clinical relevance” in this and other conditions Gouty arthritis10
Cardiac arrhythmia11 Cardiovascular disease12
Type 2 diabetes13 and metabolic syndrome — Elevated ferritin has been linked to dysfunctional glucose metabolism,14 raising the risk of diabetes fivefold in men and fourfold in women, a magnitude of correlation similar to that of obesity.15

High ferritin also doubles your risk of metabolic syndrome,16 a condition associated with an increased risk of high blood pressure, liver disease and heart disease

Alzheimer’s disease17

Iron Overload Impairs Mitochondrial Function

Iron causes significant harm primarily by catalyzing a reaction within the inner mitochondrial membrane. When iron reacts with hydrogen peroxide, hydroxyl free radicals are formed.

These are among the most damaging free radicals known, causing severe mitochondrial dysfunction, which in turn is at the heart of most chronic degenerative diseases. The hydroxyl free radicals are an oxidative stress that will also damage your cell membranes, stem cells, protein and DNA.

In addition to all this damage, recent research18 shows excessive iron also promotes apoptosis and ferroptosis in cardiomyocytes. Apoptosis is the programmed cell death of diseased and worn-out cells, and as the name implies, ferroptosis refers to cell death that is dependent on and regulated by iron specifically.19

Cardiomyocytes are muscle cells in your heart that generate and control the rhythmic contractions in your heart, thus allowing it to maintain a healthy rhythm.20 In short, this tells us that excess iron has the ability to impair your heart function by inducing mitochondrial abnormalities and the death of muscle cells in your heart.

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How Iron Overload Affects Your Risk of Alzheimer’s Disease

Aside from raising your risk of heart-related problems, iron overload is also of particular concern in Alzheimer’s disease,21,22,23 the prevalence of which has dramatically risen in recent decades.

According to research24,25 published in 2018, buildup of iron — which increases oxidative stress and has a type of “rusting effect” in your brain — is common in most Alzheimer’s patients. As noted by the authors:26

“In the presence of the pathological hallmarks of [Alzheimer’s disease], iron is accumulated within and around the amyloid-beta plaques and neurofibrillary tangles, mostly as ferrihydrite inside ferritin, hemosiderin and magnetite.

The co-localization of iron with amyloid-beta has been proposed to constitute a major source of toxicity. Indeed, in vitro, amyloid-beta has been shown to convert ferric iron to ferrous iron, which can act as a catalyst for the Fenton reaction to generate toxic free radicals, which in turn result in oxidative stress.”

Other research 27 suggests elevated cerebrospinal fluid iron levels are strongly correlated with the presence of the Alzheimer’s risk allele APOE-e4, and that elevated levels of iron in your brain may actually be the mechanism that makes APOE-e4 a major genetic risk factor for the disease.

A primary focus of conventional treatment so far has been to clear amyloid proteins, but while that approach seems logical, such attempts have met with limited success.

Researchers now suggest clearing out excess iron may be a more effective way to reduce damage and slow or prevent the Alzheimer’s disease process. You can learn more about this in “How Excess Iron Raises Your Risk for Alzheimer’s.”

Iron Dysregulation Is Surprisingly Common

It’s easy to get too much iron as it’s commonly added to most multivitamins. Many processed foods are also fortified with iron. Two servings of fortified breakfast cereal may provide as much as 44 milligrams (mg) of iron in some cases,28 bringing you dangerously close to the upper tolerance limit of 45 mg for adults, and well over the recommended daily allowance, which is a mere 8 mg for men and 18 mg for premenopausal women (i.e., women who still get their monthly period).29

Unfortunately, many doctors don’t understand or appreciate the importance of checking for iron overload. One of the greatest risk factors for iron overload is having a condition called hemochromatosis30 — one of the most prevalent genetic diseases in the U.S. — which impairs your body’s iron regulation, causing you to absorb higher than normal amounts.

The C282Y gene mutation is thought to be responsible for the majority of hemochromatosis cases. It takes two inherited copies of the mutation (one from your mother and one from your father) to cause the disease (and even then, only some people will actually get sick).

More than 30% of Americans are thought to have two copies of this defective gene31 and, according to one study,32 an estimated 40% to 70% of those with two defective C282Y genes will develop clinical evidence of iron overload.

If you have just one copy, you won’t become ill but you will still absorb slightly more iron than the rest of the population,33,34 thus placing you at increased risk for overload and the complications associated with it.

Common Factors That Increase Your Risk of Iron Overload

Virtually all adult men and postmenopausal women are also at risk for iron overload since they do not lose blood on a regular basis. Blood loss is the primary way to lower excess iron, as the body has no active excretion mechanisms. Other potential contributors to high iron levels include:

  • Cooking in iron pots or pans — Cooking acidic foods in these types of pots or pans will elevate iron absorption.
  • Eating processed food products like cereals and white breads fortified with iron — The iron used in these products is inorganic iron, not much different from rust, and it is far more dangerous than the iron in meat.
  • Drinking well water that is high in iron — The key here is to make sure you have some type of iron precipitator and/or a reverse osmosis water filter.
  • Taking multiple vitamins and mineral supplements, as both of these frequently have iron in them.
  • Regularly consuming alcohol, as this will increase the absorption of iron in your diet.

How to Check for and Address Iron Overload

Checking your iron levels is easy and can be done with a simple blood test called a serum ferritin test. I believe this is one of the most important tests that everyone should have done on a regular basis as part of a preventive, proactive health screen. The test measures the carrier molecule of iron, a protein found inside cells called ferritin, which stores the iron. If your ferritin levels are low, it means your iron levels are also low.

The healthy range of serum ferritin lies between 20 and 80 nanograms per milliliter (ng/ml). Below 20 ng/ml is a strong indicator that you are iron deficient, and above 80 ng/ml suggests you have an iron surplus. An ideal range is between 40 and 60 ng/ml.

Please note that many health sites will tell you that “normal” can be much higher than that, but as I discuss with Koenig in the earlier referenced article, levels over 300 ng/ml are particularly toxic and will eventually cause serious damage.

If you have hemochromatosis, or if a serum ferritin blood test reveals elevated iron levels, donating your blood two or three times a year is the safest, most effective and inexpensive remedy. If you have severe overload you may need to do more regular phlebotomies.

If, for some reason, a blood donor center is unable to accept your blood for donation, you can obtain a prescription for therapeutic phlebotomy. At the same time, you’ll also want to avoid consuming excess iron in the form of supplements, in your drinking water (well water), from iron cookware or fortified processed foods.

You can also limit iron absorption by not eating iron-rich foods in combination with vitamin C-rich foods or beverages, as the vitamin C boosts iron absorption. If needed, you could also take a curcumin supplement. Curcumin acts as a potent chelator of iron and can be a useful supplement if your iron is elevated.

GGT Test Is Also Advisable to Rule Out Iron Toxicity

Aside from a serum ferritin test, a gamma-glutamyl transpeptidase (GGT) test can also be used as a screening marker for excess free iron and is a great indicator of your risk for sudden cardiac death, insulin resistance, cardiometabolic disease35 and chronic kidney disease36 as well.

In recent years, scientists have discovered GGT is highly interactive with iron. Low GGT tends to be protective against higher ferritin, so if your GGT is low, you’re largely protected even if your ferritin is a bit higher than ideal.

When both your serum ferritin and GGT are high, you are at significantly increased risk of chronic health problems and early death,37,38 because then you have a combination of free iron (which is highly toxic), and the iron storage to keep that toxicity going.39 That said, even if your ferritin is low, having elevated GGT levels is cause for concern and needs to be addressed.

For this reason, getting a GGT test in addition to a serum ferritin test is advisable to rule out iron toxicity. The ideal level of GGT is below 16 units per liter (U/L) for men and below 9 U/L for women. Above 25 U/L for men and 18 U/L for women, your risk of chronic disease increases significantly.

To lower your GGT level you’ll need to implement strategies that boost glutathione, a potent antioxidant produced in your body, as GGT is inversely related to glutathione. As your GGT level rises, your glutathione goes down. This is in fact part of the equation explaining how elevated GGT harms your health. By elevating your glutathione level, you will lower your GGT.

The amino acid cysteine, found in whey protein, poultry and eggs, plays an important role in your body’s production of glutathione. Red meat, which does not contain cysteine, will tend to raise GGT, as will alcohol, so both should be avoided.40

Certain medications can also raise your GGT. If this is the case, please confer with your doctor to determine whether you might be able to stop the medication or switch to something else. General detoxification is another important component if your GGT is high, as your liver’s job is to remove toxins from your body. The fact that your GGT is elevated means your liver is under stress.

Annual Ferritin Test Is an Important Health Screen

For adults, I strongly recommend getting an annual serum ferritin test to confirm you’re neither too high nor too low. When it comes to iron overload, I believe it can be every bit as dangerous to your health as vitamin D deficiency, and checking your iron status is far more important than your cholesterol.

While a full iron panel that checks serum iron, iron-binding capacity and ferritin can be helpful, you really only need the serum ferritin test, plus the GGT test. Your doctor can write you a prescription for these tests, or you can order them from HealtheIron.com.

Again, if your ferritin is high, the easiest way to lower it is to donate blood two or three times a year. U.S. legislation allows all blood banks to perform therapeutic phlebotomy for hemochromatosis or iron overload. All you need is a doctor’s order.

Also, unless you have a lab-documented iron deficiency, avoid iron-containing multivitamins, iron supplements and mineral supplements that contain iron if your levels are already high.

– Sources and References

TMG Benefits

Written by Brenton Wight, Health Researcher, LeanMachine
Copyright © 1999-2020 Brenton Wight, LeanMachine
This site is non-profit, existing only to help people improve health and immunity
Updated 16th June 2020

TMG (Trimethylglycine) is a powerful nutrient, much like a vitamin, functioning as methyl donor, anti-oxidant, anti-inflammatory, energy booster, toxin remover, immune booster and more.
Also called betaine (first isolated from sugar beets) but different from Betaine Hydrochloride.

TMG the Methyl Donor

The TMG molecule comprises three methyl groups (CH3) joined to one molecule of glycine (C2H5NO2). The benefit of TMG is that it releases easily one, two, or all three of the methyl groups.
Releasing one methyl group then leaves behind DMG (Dimethylglycine) which is just TMG with only two methyl groups. Releasing all methyl groups leaves just Glycine, which is the smallest molecule of all of the amino acids, which allows it to go almost anywhere in the body, including crossing the blood-brain barrier.
DMG is considered a B-complex vitamin, shown to help:

  • Behaviour and speech in autistic children and adults
  • ADHD (Attention Deficit-Hyperactivity Disorder)
  • Neurological function
  • Reducing seizures
  • Stress tolerance
  • Oxygen utilisation
  • Liver activity
  • Athletic performance
  • Anti-aging
  • Anti-inflammatory
  • Anti-viral and anti-bacterial
  • Immune boosting
  • Shrinking tumours
  • Allergies
  • Chronic fatigue syndrome
  • Respiratory disorders
  • Alcoholism, drug addiction.
  • Cholesterol and triglycerides
  • Blood pressure
  • Blood glucose

Although DMG has all of these benefits, and is available as a supplement, LeanMachine recommends that people supplement with TMG as we then receive all of the benefits of DMG plus the benefit of 50% better methylation.

Methyl groups (CH3) are essential for millions of biochemical reactions every second in the body, these are a few examples:

  • Lowering homocysteine, an amino acid, which inflames arteries when levels rise, leading to “hardening of the arteries”. Homocysteine levels are a much better indicator of cardiovascular disease than cholesterol. High homocysteine is commonly caused by insufficient methyl groups. The body gets methyl groups from TMGActive FolateActive Vitamin B-12, SAM-eDMAEMethionineTaurine, Cysteine and Vitamin B-6.
    Other causes of high homocysteine are mercury and copper toxicity. High homocysteine also causes methionine deficiency, in turn causing SAM-e (S-Adenosyl Methionine) deficiency which can lead to depression. Methionine is required for protein synthesis
  • Excess homocysteine also leads to osteoporosis, birth defects, cancer, ageing and free radicals, all helped by TMG
  • Methyl groups are required for the Phase 2, P450 liver detoxification pathway, a critical biochemical sequence of events. Fat-soluble toxins are joined to a methyl group, enabling a greater water solubility, then allowing the liver to remove them from the body. For toxins unable to be removed, methylation helps render them less toxic
  • TMG increases production of SAM-e, helping to reduce depression
  • TMG reduces risk of diabetes, as insulin release and insulin activity rely on methyl group donation
  • TMG donates methyl groups for protein synthesis (biosynthesis), the copying of genetic code from DNA to RNA (genetic transcription), then to the synthesis (formation) of every chemical in the body
  • TMG insufficiency causes biosynthesis slowing, telomeres shortening, and genetic errors (transcription errors) raises cancer risk from DNA mutations

The Methylation Process

This is a vital and most common chemical process in hundreds of essential chemical reactions, including:

  • Methylation is essential for manufacture of all the chemicals for the body
  • Stops certain viruses that could damage DNA
  • Stops the production of trophoblast (fast-growing cells that may lead to cancer)
  • Suppresses replication of DNA in areas where the body does not want it replicated
  • Important for neurological chemicals and blood chemicals
  • Corrects timing problems of the X chromosome in cell replication
  • Causea a genetic trait to come from only one parent, and not both
  • Prevents some genetic diseases
  • Helps prevent shortening of gene telomeres
  • Methylation is a primary method of removing toxins in the phase 2 liver detoxification system
  • Methylation converts toxins of all kinds from insoluble, less soluble or fat-soluble compounds into water-soluble compounds to allow excretion. Larger molecules are eliminated through the bile, smaller ones are excreted in the urine
  • Methylation is required for synthesis of dopamine and serotonin, improving mood, energy, wellbeing, alertness, concentration, and visual clarity
  • Methylation helps with liver detoxification
  • Methylation is required for conversion of homocysteine to methionine, which converts to other amino acids by various pathways
  • Methylation helps balance hormones such as estrogens, reducing risk of estrogen-related cancers
  • Reduces inflammation by removing toxins, balancing hormones, synthesising neurotransmitters and other methods
  • Methylation protects the mitochondria and adaptive energy production to stop us from becoming very tired
  • Restores SAM-e in spinal fluid, working as a methyl donor when restored by methyl groups
  • Methylation is required for the body to make CoQ10 (Coenzyme Q10), vital for heart health and energy production in the mitochondria
  • Methylation increases muscle mass, important in cancer and other wasting diseases, and for general health
  • Methylation may improve libido in some people

Who needs TMG?

Almost everyone needs supplemental TMG, even healthy people with a healthy diet, to provide enough methylation for modern life. Those subject to stress, toxins, cardiovascular disease, mental illness, depression, fatigue, exhaustion or almost any other medical condition, almost certainly need extra TMG.

Other benefits of TMG

The Parasympathetic System

TMG can improve the parasympathetic system, helping balance the autonomic nervous system. Hair mineral analyses show about half the population has an autonomic nervous system imbalance (sympathetic dominance), where the sympathetic (fight-or-flight) nervous system is “switched on” too often and too long, usually due to stress, causing many chronic health conditions. TMG may help reverse any imbalance, contributing to healing. Some doctors use “sympathetic dominance” in a different context such as “a sympathetic state of body chemistry” which is different from “sympathetic dominance” used here.

The MTHFR Defect

Almost half the people on Earth have the abnormal MTHFR gene expression, where the biosynthesis of folate is reduced, sometimes marginally, sometimes largely.
Often incorrectly called a “genetic defect” when it is actually a transcription error, polymorphism or abnormal gene expression where errors occur in copying the DNA code rather than a problem with the actual DNA code.
This is why Active Folate has benefits, as it is already in the (6S)-5-methyltetrahydrofolate form required by the body, while regular folate must be converted in the body to this form.
TMG can help supply the methyl groups where insufficent folate cannot. Active folate can be up to 700% more useful in the body, compared to regular folic acid. Note that folic acid is a cheap folate substitute used in many foods claiming to be “folate enriched” but folic acid may prevent absorption of real folate in foods or active folate supplements, and LeanMachine advises total avoidance of foods or supplements containing folic acid.

Antioxidant and anti-inflammatory

There are not many reports on these properties, but they do exist, possibly as a result of methyl group donation

Effects on the Brain

TMG has a positive effect on the brain, likely due to methylation and SAM-e production. Recommended for those at high risk for Alzheimer’s, dementia, Parkinsons, depression, anxiety, seizures, migraine headache, ADHD (Attention Deficit-Hyperactivity Disorder), MS (Multiple Sclerosis) and other brain conditions.

SAM-e Benefits

1. Heart Disease

SAM-e is used for heart disease, also for fibromyalgia, abdominal pain, osteoarthritis, bursitis, tendonitis, chronic lower back pain, ageing, CFS (Chronic Fatigue Syndrome), improving mental performance, liver disease, spinal cord injury, lead poisoning, to break down bilirubin or porphyrin (or precursors).

2. PMS

SAM-e is often taken for PMS (Premenstrual Syndrome) and a more severe form PMDD (Premenstrual Dysphoric Disorder).

IV use of SAM-e

IV (Intravenous) use of SAM-e is used for depression, osteoarthritis, AIDS-related nervous system disorders, fibromyalgia, liver disease, cirrhosis, and intrahepatic cholestasis (a liver disorder in pregnant women)

SAM-e Injections

SAM-e is often injected for fibromyalgia, depression, and Alzheimer’s disease.

Effects on Digestion

TMG aids digestion, again likely because of positive methylation throughout the body.

Glycine

Glycine is the component left over when all three methyl groups have been donated from TMG.
Glycine is the smallest of the amino acids and very important for collagen formation and many other functions. Collagen, the most abundant protein in the body, is used for connective tissue: Tendons, ligaments, cartilage, skin, nails, arteries, veins, etc. Without collagen, we could not stand up, our body would be a pile of mush on the floor!
Glycine, in large doses (up to 3000 mg daily), has been found helpful for sleep and alertness. Although not recommended as a first-line supplement for sleep, it may help if other supplements like Valerian fail to work. This may explain why TMG helps induce restful sleep in some individuals.

Natural sources of TMG

TMG is normally made in the body, but not enough when there are toxins present or the diet is poor or absorption of nutrients is a problem.
TMG can come from the diet. Foods high in TMG include broccoli, quinoa, spinach, lamb, chicken, and beets. A vegetarian or vegan diet tends to be very low in TMG. Foods high in TMG are usually also high in folate, and both are methyl donors.
However, most people do not eat enough of these foods, and even eating large amounts will not provide enough TMG for optimum health.

Risk factors for low TMG

Generally, the body cannot make enough, the modern diet is poor in TMG, and the number of pesticides, chemicals, heavy metal contamination uses up all TMG available.

  • Mercury is a poison that lowers TMG production in the body, and at the same time increases the need for TMG in the body. Almost everyone is mercury toxic now, as mercury is everywhere in the environment, especially in seafood and in dental amalgam fillings
  • Copper toxicity also interferes with TMG, and most people today are toxic from copper pipes, tapware, cookware even if blood or urine tests are negative. While copper is essential for the body to build hemoglobin in blood, we need Chelated Copper from food or supplements, not metallic copper from copper pipes and cookware. Zinc deficiencies cause accumulation of copper in the body, and women have a higher risk than men. Causes headaches, female organ problems, depression, anxiety, skin conditions. Too much zinc (and/or magnesium) competes with copper for absorption, often leading to a copper deficiency.

Supplements

Supplementary TMG is helpful for most people because of low body production, low in the diet, and higher requirements in our toxic world.
TMG 1000mg 100 tablets (most popular, best value).

Stress

Stress, inflammation, inflammation and some diseases increase our need for more TMG.

Dosage of TMG

  • Women: Up to 1000 mg daily
  • Men: Up to 3000 mg daily
  • Children: Less than adults, in proportion to body weight

There are no reliable guides or tests to determine TMG dosage, but the figures above should be a good starting point.
If the sodium/potassium ratio is low, extra TMG may help.
Do not overdose, as too much TMG may lead to over-methylation, causing fatigue, nausea, hair loss, dizziness or other symptoms.
Most people have no side effects from TMG apart from feeling better, getting better sleep and having more energy.
Cautions:
Do not continue a high dose for extended periods.
Children need proportionately less TMG than adults, depending on their size and weight, but babies generally do not need TMG. Older children may need about 250 to 500 mg daily.
TMG is available as tablets, liquid capsules or crystals. Some children and the elderly may have problems with swallowing tablets. TMG has a sweet taste, so TMG crystals can be simply added to food.
Some people have problems tolerating TMG, so they may need a smaller dose. Try reducing the dose until any symptoms disappear.
People who have unresolved resentments seem to have more problems taking TMG, as an enzyme is activated which can cause anger, fear, depression or anxiety symptoms. These symptoms disappear if the dose is reduced or eliminated, but if one can tolerate the symptoms, TMG may help the person resolve their issues of conflict.
Some reports suggest that too much TMG may cause diarrhea and nausea, and may raise cholesterol levels, so those with high cholesterol should keep the level monitored.

Poor Methylation

Several factors affect poor methylation, such as:

  • Raw vegetables are considered healthy, but cooked vegetables provide more dietary methyl groups
  • Sugars in any form appear to harm correct methylation, and are bad for our health anyway
  • Fermented foods are healthy, but are problem for methylation because:
    • Some contain aldehydes (toxic to the liver), including kombucha tea, kimchi, and most fermented grains
    • They contain ferments, which are bacteria or yeasts

    Safer fermented foods, eaten in moderation, include yogurt, kefir, miso and most good quality cheeses

  • Too much animal protein in the diet can cause high methionine and reduce methylation
  • Fighting inflammation or infections consumes methyl groups, requiring more methylation
  • Heavy metal toxicity, especially copper and mercury, interfere with methyl group formation
  • High-dose niacin or niacinamide cause the body to use up methyl groups to detoxify and excrete niacin through the liver. Doses less than 50 mg daily are generally tolerated well
  • Any liver toxins will reduce formation of methyl donors, also liver detoxification pathways require methyl groups, using up more methyl groups
  • Methyl donor production seems to decrease with age, so seniors need more TMG
  • Women of child-bearing age have much better methylation than men. Men always need more TMG than women

Methylation and Cancer

Cancer increases the need for methylating agents like TMG. People often die with cancer because they cannot eliminate their toxic metals and chemicals because of poor liver methylation, so toxins accumulate until death occurs.

Hair Mineral Analysis

More TMG may be required if a hair mineral test reveals:

  • High zinc level, which may indicate presence of hidden toxic metals
  • “Four lows pattern” meaning all four electrolyte minerals low: Calcium, Magnesium, Sodium, Potassium. Indicates impaired methylation
  • High mercury, becoming more common
  • High copper
  • High levels of the other toxic metals

These results indicate long-term toxic metal exposure.

Disclaimer

LeanMachine is not a doctor, and everyone should consult with their own health professional before taking any product to ensure there is no conflict with existing prescription medication.
LeanMachine has been researching nutrition and health since 2010 and has completed many relevant studies including:
Open2Study, Australia – Food, Nutrition and Your Health
RMIT University, Australia – Foundations of Psychology
Swinburne University of Technology, Australia – Chemistry – Building Blocks of the World
University of Washington, USA – Energy, Diet and Weight
Johns Hopkins Bloomberg School of Public Health, USA – Health Issues for Aging Populations
Johns Hopkins Bloomberg School of Public Health, USA – International Nutrition
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics I
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics II
Johns Hopkins Bloomberg School of Public Health, USA – Principles of Human Nutrition
TUFTS University, USA – Nutrition and Medicine
TUFTS University, USA – Lipids/Cardiovascular Disease I and Lipids/Cardiovascular Disease II
Technical Learning College, USA – Western Herbology, Identification, Formulas
Bath University, England – Inside Cancer
WebMD Education – The Link Between Stroke and Atrial Fibrillation
WebMD Education – High Potassium: Causes and Reasons to Treat
Leiden University Medical Center, Netherlands – Anatomy of the Abdomen and Pelvis
MIT (Massachusetts Institute of Technology) – A Clinical Approach to the Human Brain
LeanMachine has now examined thousands of studies, journals and reports related to health and nutrition and this research is ongoing.

Updated 16th June 2020, Copyright © 1999-2020 Brenton Wight and BJ & HJ Wight trading as Lean Machine abn 55293601287

Protect yourself from liver damage with phosphatidylcholine

Reproduced from original article:
www.naturalhealth365.com/phosphatidylcholine-liver-damage-3239.html
by: | December 31, 2019
liver-damage
(NaturalHealth365)  Nonalcoholic fatty liver disease – defined as excess fat in the liver in the absence of chronic alcohol abuse – is fast becoming a pandemic in the United States. According to recent research, the national prevalence of NAFLD has soared from 18 percent of the population (in 1991) to an astounding 31 percent in 2012 – and death rates from chronic liver disease are on the rise as well.Fortunately, a natural nutrient known as phosphatidylcholine is showing the potential to slow and even reverse fatty liver damage, while protecting against damage from a variety of toxins.

In spite of decades of clinical trials demonstrating phosphatidylcholine’s protective effects, this lecithin-like nutrient still seems to be relatively little-known – and underappreciated – by most people.

Essential NEWS: Phosphatidylcholine makes up 65 percent of all cell membranes

In addition to functioning as the body’s major detoxifying organ, the liver also stores vitamins, assists in the absorption of nutrients, secretes hormones and metabolizes body waste and toxins into water-soluble compounds to be eliminated.

Researchers have learned that most of the life-sustaining activities performed by the liver actually occur on the membranes of the parenchymal cells (known as the “workhorses of the liver”).

Phosphatidylcholine – which is produced by the liver – is absolutely essential for the structure and function of these cells.  Although the parenchymal cells are normally protected by antioxidants such as glutathione and cysteine, exposure to environmental toxins, viruses and bacteria can deplete these protective enzymes and jeopardize levels of phosphatidylcholine (PC).

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And that’s where the trouble really begins.  Protective cell membranes lose their integrity and develop holes, leading to leakage of vital enzymes and, eventually, cell death – which in turn causes inflammatory and necrotic damage to liver tissue.

In order to avoid this scenario, and to continue to carry out its life-sustaining duties, the liver must create new cell membranes – for which PC is a key ingredient.

In a groundbreaking German study conducted in 1973, researchers began to evaluate PC’s therapeutic effects on liver disease in humans – and evidence of PC’s benefits has continued to accumulate ever since.

Phosphatidylcholine can reverse alcoholic liver damage, study says

To conduct the five-year study, the team gave PC daily to 650 subjects with varying degrees of liver damage, then regularly assessed them through biopsies, blood analysis and clinical tests.

Participants’ liver disease ranged from mild to severe – and included fatty degeneration, aggressive inflammation and advanced fibrotic damage.

The subjects were first given PC both orally and intravenously – then were switched to oral supplementation at 450 to 700 mg a day.  The results were striking!

Over 50 percent of participants with mild liver damage showed “excellent” improvement – and even experienced reversal of fatty deposits.

In participants with persistent inflammation, PC returned enzyme parameters to normal after 30 days.  And, of those with the most severe and aggressive chronic inflammation, more than one-third experienced a benefit.

PC supplementation even benefited 17 percent of those with advanced liver scarring – an impressive finding in light of the fact that some of the participants had failed to benefit in the past from other treatments, including steroid drugs and milk thistle extract.

The impressed researchers concluded that PC was the “best single means” for managing liver damage – quite an endorsement!

Warning: Alcohol strips much-needed PC from cell membranes and triggers the development of a fatty liver

PC seems custom-designed to help protect the body from the harmful effects of ethyl alcohol (the type found in beer, wine and liquor).  These damaging effects include damage to mitochondria – the “power centers” of the cells – oxidative stress, antioxidant depletion and inhibition of the liver’s detoxification system.

In addition, alcohol molecules are metabolized to become acetaldehyde (the harmful toxin that is responsible for hangover misery).

Perhaps most alarmingly, alcohol dissolves phosphatidylcholine from the parenchymal cell membranes – jeopardizing their ability to metabolize triglycerides (fat) and setting the stage for inflammation and deposits of fat in the liver.

In fact, so effective is PC at metabolizing lipids that it is used in cosmetic injections to dissolve fat.  Clearly, supplementation with PC is a valuable tool in addressing liver dysfunction.

In an article published in Alternative Medicine Review, the author notes that extensive animal studies have shown that PC slows the progression of fatty liver disease and helps reduce liver fibrosis, or scarring.  And, the German study is one of many showing that PC’s fat-burning and liver-restoring effects translate into therapeutic benefits for human patients with fatty livers.

Additional studies have shown that 1,000 to 3,000 mg a day of phosphatidylcholine can protect the liver by reducing the leakage of enzymes, decreasing the harmful oxidation of fats, slowing membrane damage and preserving membrane integrity.

A liver “MVP,” phosphatidylcholine also protects against damage from medications, pollutants and viruses

Of course, alcohol is far from the only threat to liver health.

Over-the-counter and prescribed medications – including acetaminophen, aspirin, ibuprofen, antibiotics and benzodiazepines – also take a toll on the liver, as does exposure to herbicides, pesticides and electromagnetic radiation from smart phones and laptops.

Animal and clinical studies have shown that PC defends the liver against these, as well.  In one study, PC was even found to be effective against Amanita phalloides, the notorious “deathcap” mushroom.

In other research, PC helped to resolve liver damage from hepatitis A and B, while improving general well-being.  Note: In 20 percent of the PC-treated patients, the virus was found to be “inactive” – a truly encouraging result!

Support liver health with phosphatidylcholine supplementation

Phosphatidylcholine is produced in the liver, and is also found in some foods – including cage-free eggs, organic soybeans, mustard and sunflower seeds.

Clearly, supplementation could be a wise move for those dealing with fatty liver disease.

Natural healers may recommend dosages in the area of 500 mg to 3,000 mg of phosphatidylcholine a day. Of course, check first with your integrative doctor before supplementing with PC.

As a “bonus tip:” PC is not only highly bioavailable – with about 90 percent absorption over 24 hours – but it also enhances the bioavailability of other nutrients, such as flavonoids, that are taken along with it.

No doubt, researchers are hailing PC as an “effective and safe nutrient for liver damage of all levels of severity.”  And, with fatty liver disease becoming rampant in the United States, PC’s ability to reduce and prevent fatty deposits and fibrosis is certainly good news.

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Sources for this article include:

Semanticscholar.org
Naturalhealth365.com