Liver

now browsing by category

 

Iron Overload Destroys Mitochondria and Sabotages Health


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2020/01/15/iron-overload-destroys-mitochondria.aspx

Analysis by Dr. Joseph Mercola Fact Checked image
January 15, 2020
iron overload destroys mitochondria

STORY AT-A-GLANCE

  • Iron is essential for life as it transfers oxygen to your tissues. Hemoglobin, the protein in your red blood cells, contains iron at its core, which reversibly binds to oxygen and supplies your tissues with it
  • Without proper oxygenation, your cells quickly start dying. However, excess iron can also cause severe problems by encouraging oxidation and tissue damage
  • Common health problems associated with elevated iron levels include cirrhosis, cancer, hepatitis C, gouty arthritis, arrhythmia, cardiovascular disease, Type 2 diabetes, Alzheimer’s and more
  • Recent research shows excessive iron damages mitochondrial function and impairs your heart function by inducing the death of muscle cells in your heart
  • Your iron level can be easily determined with a serum ferritin test. I believe this is one of the most important tests that everyone should have done on a regular basis as part of a preventive, proactive health screen

Iron is necessary for life as it essential to transfer oxygen into your tissues. Hemoglobin, the protein in your red blood cells that contains iron at its core, reversibly binds to oxygen and supplies your tissues with it. Without proper oxygenation, your cells quickly start dying.

Iron is also a key component of various proteins and enzymes, and is involved in energy production, immune function, metabolism and endocrine function. For these reasons, low iron (anemia) can cause significant health problems.

However, what many don’t realize is that excess iron is actually more common than too little, and iron overload can be even more problematic, as detailed in “Why Managing Your Iron Level Is Crucial to Your Health,” which features my interview with Gerry Koenig, former chairman of the Iron Disorders Institute and the Hemochromatosis Foundation.

Because your body has a limited capacity to excrete iron, it can easily build up in organs like your liver, heart and pancreas. This is dangerous because iron is a potent oxidizer that can damage your tissues and contribute to a variety of health problems, including but not limited to:

Cirrhosis1 Cancer, including bowel,2 liver3 and lung cancer4 — Elevated ferritin is associated with a 2.9 times higher risk of death from cancer5 and blood donors have been shown to have a lower likelihood of developing certain cancers than nondonors6,7
Hepatitis C8 — As noted in a 2007 paper,9 even “mild or moderate increase of iron stores appears to have significant clinical relevance” in this and other conditions Gouty arthritis10
Cardiac arrhythmia11 Cardiovascular disease12
Type 2 diabetes13 and metabolic syndrome — Elevated ferritin has been linked to dysfunctional glucose metabolism,14 raising the risk of diabetes fivefold in men and fourfold in women, a magnitude of correlation similar to that of obesity.15

High ferritin also doubles your risk of metabolic syndrome,16 a condition associated with an increased risk of high blood pressure, liver disease and heart disease

Alzheimer’s disease17

Iron Overload Impairs Mitochondrial Function

Iron causes significant harm primarily by catalyzing a reaction within the inner mitochondrial membrane. When iron reacts with hydrogen peroxide, hydroxyl free radicals are formed.

These are among the most damaging free radicals known, causing severe mitochondrial dysfunction, which in turn is at the heart of most chronic degenerative diseases. The hydroxyl free radicals are an oxidative stress that will also damage your cell membranes, stem cells, protein and DNA.

In addition to all this damage, recent research18 shows excessive iron also promotes apoptosis and ferroptosis in cardiomyocytes. Apoptosis is the programmed cell death of diseased and worn-out cells, and as the name implies, ferroptosis refers to cell death that is dependent on and regulated by iron specifically.19

Cardiomyocytes are muscle cells in your heart that generate and control the rhythmic contractions in your heart, thus allowing it to maintain a healthy rhythm.20 In short, this tells us that excess iron has the ability to impair your heart function by inducing mitochondrial abnormalities and the death of muscle cells in your heart.

Advertisement

Click here to find out why 5G wireless is NOT harmless


How Iron Overload Affects Your Risk of Alzheimer’s Disease

Aside from raising your risk of heart-related problems, iron overload is also of particular concern in Alzheimer’s disease,21,22,23 the prevalence of which has dramatically risen in recent decades.

According to research24,25 published in 2018, buildup of iron — which increases oxidative stress and has a type of “rusting effect” in your brain — is common in most Alzheimer’s patients. As noted by the authors:26

“In the presence of the pathological hallmarks of [Alzheimer’s disease], iron is accumulated within and around the amyloid-beta plaques and neurofibrillary tangles, mostly as ferrihydrite inside ferritin, hemosiderin and magnetite.

The co-localization of iron with amyloid-beta has been proposed to constitute a major source of toxicity. Indeed, in vitro, amyloid-beta has been shown to convert ferric iron to ferrous iron, which can act as a catalyst for the Fenton reaction to generate toxic free radicals, which in turn result in oxidative stress.”

Other research 27 suggests elevated cerebrospinal fluid iron levels are strongly correlated with the presence of the Alzheimer’s risk allele APOE-e4, and that elevated levels of iron in your brain may actually be the mechanism that makes APOE-e4 a major genetic risk factor for the disease.

A primary focus of conventional treatment so far has been to clear amyloid proteins, but while that approach seems logical, such attempts have met with limited success.

Researchers now suggest clearing out excess iron may be a more effective way to reduce damage and slow or prevent the Alzheimer’s disease process. You can learn more about this in “How Excess Iron Raises Your Risk for Alzheimer’s.”

Iron Dysregulation Is Surprisingly Common

It’s easy to get too much iron as it’s commonly added to most multivitamins. Many processed foods are also fortified with iron. Two servings of fortified breakfast cereal may provide as much as 44 milligrams (mg) of iron in some cases,28 bringing you dangerously close to the upper tolerance limit of 45 mg for adults, and well over the recommended daily allowance, which is a mere 8 mg for men and 18 mg for premenopausal women (i.e., women who still get their monthly period).29

Unfortunately, many doctors don’t understand or appreciate the importance of checking for iron overload. One of the greatest risk factors for iron overload is having a condition called hemochromatosis30 — one of the most prevalent genetic diseases in the U.S. — which impairs your body’s iron regulation, causing you to absorb higher than normal amounts.

The C282Y gene mutation is thought to be responsible for the majority of hemochromatosis cases. It takes two inherited copies of the mutation (one from your mother and one from your father) to cause the disease (and even then, only some people will actually get sick).

More than 30% of Americans are thought to have two copies of this defective gene31 and, according to one study,32 an estimated 40% to 70% of those with two defective C282Y genes will develop clinical evidence of iron overload.

If you have just one copy, you won’t become ill but you will still absorb slightly more iron than the rest of the population,33,34 thus placing you at increased risk for overload and the complications associated with it.

Common Factors That Increase Your Risk of Iron Overload

Virtually all adult men and postmenopausal women are also at risk for iron overload since they do not lose blood on a regular basis. Blood loss is the primary way to lower excess iron, as the body has no active excretion mechanisms. Other potential contributors to high iron levels include:

  • Cooking in iron pots or pans — Cooking acidic foods in these types of pots or pans will elevate iron absorption.
  • Eating processed food products like cereals and white breads fortified with iron — The iron used in these products is inorganic iron, not much different from rust, and it is far more dangerous than the iron in meat.
  • Drinking well water that is high in iron — The key here is to make sure you have some type of iron precipitator and/or a reverse osmosis water filter.
  • Taking multiple vitamins and mineral supplements, as both of these frequently have iron in them.
  • Regularly consuming alcohol, as this will increase the absorption of iron in your diet.

How to Check for and Address Iron Overload

Checking your iron levels is easy and can be done with a simple blood test called a serum ferritin test. I believe this is one of the most important tests that everyone should have done on a regular basis as part of a preventive, proactive health screen. The test measures the carrier molecule of iron, a protein found inside cells called ferritin, which stores the iron. If your ferritin levels are low, it means your iron levels are also low.

The healthy range of serum ferritin lies between 20 and 80 nanograms per milliliter (ng/ml). Below 20 ng/ml is a strong indicator that you are iron deficient, and above 80 ng/ml suggests you have an iron surplus. An ideal range is between 40 and 60 ng/ml.

Please note that many health sites will tell you that “normal” can be much higher than that, but as I discuss with Koenig in the earlier referenced article, levels over 300 ng/ml are particularly toxic and will eventually cause serious damage.

If you have hemochromatosis, or if a serum ferritin blood test reveals elevated iron levels, donating your blood two or three times a year is the safest, most effective and inexpensive remedy. If you have severe overload you may need to do more regular phlebotomies.

If, for some reason, a blood donor center is unable to accept your blood for donation, you can obtain a prescription for therapeutic phlebotomy. At the same time, you’ll also want to avoid consuming excess iron in the form of supplements, in your drinking water (well water), from iron cookware or fortified processed foods.

You can also limit iron absorption by not eating iron-rich foods in combination with vitamin C-rich foods or beverages, as the vitamin C boosts iron absorption. If needed, you could also take a curcumin supplement. Curcumin acts as a potent chelator of iron and can be a useful supplement if your iron is elevated.

GGT Test Is Also Advisable to Rule Out Iron Toxicity

Aside from a serum ferritin test, a gamma-glutamyl transpeptidase (GGT) test can also be used as a screening marker for excess free iron and is a great indicator of your risk for sudden cardiac death, insulin resistance, cardiometabolic disease35 and chronic kidney disease36 as well.

In recent years, scientists have discovered GGT is highly interactive with iron. Low GGT tends to be protective against higher ferritin, so if your GGT is low, you’re largely protected even if your ferritin is a bit higher than ideal.

When both your serum ferritin and GGT are high, you are at significantly increased risk of chronic health problems and early death,37,38 because then you have a combination of free iron (which is highly toxic), and the iron storage to keep that toxicity going.39 That said, even if your ferritin is low, having elevated GGT levels is cause for concern and needs to be addressed.

For this reason, getting a GGT test in addition to a serum ferritin test is advisable to rule out iron toxicity. The ideal level of GGT is below 16 units per liter (U/L) for men and below 9 U/L for women. Above 25 U/L for men and 18 U/L for women, your risk of chronic disease increases significantly.

To lower your GGT level you’ll need to implement strategies that boost glutathione, a potent antioxidant produced in your body, as GGT is inversely related to glutathione. As your GGT level rises, your glutathione goes down. This is in fact part of the equation explaining how elevated GGT harms your health. By elevating your glutathione level, you will lower your GGT.

The amino acid cysteine, found in whey protein, poultry and eggs, plays an important role in your body’s production of glutathione. Red meat, which does not contain cysteine, will tend to raise GGT, as will alcohol, so both should be avoided.40

Certain medications can also raise your GGT. If this is the case, please confer with your doctor to determine whether you might be able to stop the medication or switch to something else. General detoxification is another important component if your GGT is high, as your liver’s job is to remove toxins from your body. The fact that your GGT is elevated means your liver is under stress.

Annual Ferritin Test Is an Important Health Screen

For adults, I strongly recommend getting an annual serum ferritin test to confirm you’re neither too high nor too low. When it comes to iron overload, I believe it can be every bit as dangerous to your health as vitamin D deficiency, and checking your iron status is far more important than your cholesterol.

While a full iron panel that checks serum iron, iron-binding capacity and ferritin can be helpful, you really only need the serum ferritin test, plus the GGT test. Your doctor can write you a prescription for these tests, or you can order them from HealtheIron.com.

Again, if your ferritin is high, the easiest way to lower it is to donate blood two or three times a year. U.S. legislation allows all blood banks to perform therapeutic phlebotomy for hemochromatosis or iron overload. All you need is a doctor’s order.

Also, unless you have a lab-documented iron deficiency, avoid iron-containing multivitamins, iron supplements and mineral supplements that contain iron if your levels are already high.

– Sources and References

TMG Benefits

TMG (Trimethylglycine) is a powerful nutrient, much like a vitamin, functioning as methyl donor, anti-oxidant, anti-inflammatory, energy booster, toxin remover, immune booster and more.
Also called betaine (first isolated from sugar beets) but different from Betaine Hydrochloride.

TMG the Methyl Donor

The TMG molecule comprises three methyl groups (CH3) joined to one molecule of glycine (C2H5NO2). The benefit of TMG is that it releases easily one, two, or all three of the methyl groups.
Releasing one methyl group then leaves behind DMG (Dimethylglycine) which is just TMG with only two methyl groups. Releasing all methyl groups leaves just Glycine, which is the smallest molecule of all of the amino acids, which allows it to go almost anywhere in the body, including crossing the blood-brain barrier.
DMG is considered a B-complex vitamin, shown to help:

  • Behaviour and speech in autistic children and adults
  • ADHD (Attention Deficit-Hyperactivity Disorder)
  • Neurological function
  • Reducing seizures
  • Stress tolerance
  • Oxygen utilisation
  • Liver activity
  • Athletic performance
  • Anti-aging
  • Anti-inflammatory
  • Anti-viral and anti-bacterial
  • Immune boosting
  • Shrinking tumours
  • Allergies
  • Chronic fatigue syndrome
  • Respiratory disorders
  • Alcoholism, drug addiction.
  • Cholesterol and triglycerides
  • Blood pressure
  • Blood glucose

Although DMG has all of these benefits, and is available as a supplement, LeanMachine recommends that people supplement with TMG as we then receive all of the benefits of DMG plus the benefit of 50% better methylation.

Methyl groups (CH3) are essential for millions of biochemical reactions every second in the body, these are a few examples:

  • Lowering homocysteine, an amino acid, which inflames arteries when levels rise, leading to “hardening of the arteries”. Homocysteine levels are a much better indicator of cardiovascular disease than cholesterol. High homocysteine is commonly caused by insufficient methyl groups. The body gets methyl groups from TMGActive FolateActive Vitamin B-12, SAM-eDMAEMethionineTaurine, Cysteine and Vitamin B-6.
    Other causes are mercury and copper toxicity. High homocysteine also causes methionine deficiency, in turn causing SAM-e (S-Adenosyl Methionine) deficiency which can lead to depression. Methionine is required for protein synthesis
  • Excess homocysteine also leads to osteoporosis, birth defects, cancer, ageing and free radicals, all helped by TMG
  • Methyl groups are required for the Phase 2, P450 liver detoxification pathway, a critical biochemical sequence of events. Fat-soluble toxins are joined to a methyl group, enabling a greater water solubility, then allowing the liver to remove them from the body. For toxins unable to be removed, methylation helps render them less toxic
  • TMG increases production of SAM-e, helping to reduce depression
  • TMG reduces risk of diabetes, as insulin release and insulin activity rely on methyl group donation
  • TMG donates methyl groups for protein synthesis (biosynthesis), the copying of genetic code from DNA to RNA (genetic transcription), then to the synthesis (formation) of every chemical in the body
  • TMG insufficiency causes biosynthesis slowing, telomeres shortening, and genetic errors (transcription errors) raises cancer risk from DNA mutations

The Methylation Process

This is a vital and most common chemical process in hundreds of essential chemical reactions, including:

  • Methylation is essential for manufacture of all the chemicals for the body
  • Stops certain viruses that could damage DNA
  • Stops the production of trophoblast (fast-growing cells that may lead to cancer)
  • Suppresses replication of DNA in areas where the body does not want it replicated
  • Important for neurological chemicals and blood chemicals
  • Corrects timing problems of the X chromosome in cell replication
  • Causea a genetic trait to come from only one parent, and not both
  • Prevents some genetic diseases
  • Helps prevent shortening of gene telomeres
  • Methylation is a primary method of removing toxins in the phase 2 liver detoxification system
  • Methylation converts toxins of all kinds from insoluble, less soluble or fat-soluble compounds into water-soluble compounds to allow excretion. Larger molecules are eliminated through the bile, smaller ones are excreted in the urine
  • Methylation is required for synthesis of dopamine and serotonin, improving mood, energy, wellbeing, alertness, concentration, and visual clarity
  • Methylation helps with liver detoxification
  • Methylation is required for conversion of homocysteine to methionine, which converts to other amino acids by various pathways
  • Methylation helps balance hormones such as estrogens, reducing risk of estrogen-related cancers
  • Reduces inflammation by removing toxins, balancing hormones, synthesising neurotransmitters and other methods
  • Methylation protects the mitochondria and adaptive energy production to stop us from becoming very tired
  • Restores SAM-e in spinal fluid, working as a methyl donor when restored by methyl groups
  • Methylation is required for the body to make CoQ10 (Coenzyme Q10), vital for heart health and energy production in the mitochondria
  • Methylation increases muscle mass, important in cancer and other wasting diseases, and for general health
  • Methylation may improve libido in some people

Who needs TMG?

Almost everyone needs supplemental TMG, even healthy people with a healthy diet, to provide enough methylation for modern life. Those subject to stress, toxins, cardiovascular disease, mental illness, depression, fatigue, exhaustion or almost any other medical condition, almost certainly need extra TMG.

Other benefits of TMG

The Parasympathetic System

TMG can improve the parasympathetic system, helping balance the autonomic nervous system. Hair mineral analyses show about half the population has an autonomic nervous system imbalance (sympathetic dominance), where the sympathetic (fight-or-flight) nervous system is “switched on” too often and too long, usually due to stress, causing many chronic health conditions. TMG may help reverse any imbalance, contributing to healing. Some doctors use “sympathetic dominance” in a different context such as “a sympathetic state of body chemistry” which is different from “sympathetic dominance” used here.

The MTHFR Defect

Almost half the people on Earth have the abnormal MTHFR gene expression, where the biosynthesis of folate is reduced, sometimes marginally, sometimes largely.
Often incorrectly called a “genetic defect” when it is actually a transcription error, polymorphism or abnormal gene expression where errors occur in copying the DNA code rather than a problem with the actual DNA code.
This is why Active Folate has benefits, as it is already in the (6S)-5-methyltetrahydrofolate form required by the body, while regular folate must be converted in the body to this form.
TMG can help supply the methyl groups where insufficent folate cannot. Active folate can be up to 700% more useful in the body, compared to regular folic acid. Note that folic acid is a cheap folate substitute used in many foods claiming to be “folate enriched” but folic acid may prevent absorption of real folate in foods or active folate supplements, and LeanMachine advises total avoidance of foods or supplements containing folic acid.

Antioxidant and anti-inflammatory

There are not many reports on these properties, but they do exist, possibly as a result of methyl group donation

Effects on the Brain

TMG has a positive effect on the brain, likely due to methylation and SAM-e production. Recommended for those at high risk for Alzheimer’s, dementia, Parkinsons, depression, anxiety, seizures, migraine headache, ADHD (Attention Deficit-Hyperactivity Disorder), MS (Multiple Sclerosis) and other brain conditions.

SAM-e Benefits

1. Heart Disease

SAM-e is used for heart disease, also for fibromyalgia, abdominal pain, osteoarthritis, bursitis, tendonitis, chronic lower back pain, ageing, CFS (Chronic Fatigue Syndrome), improving mental performance, liver disease, spinal cord injury, lead poisoning, to break down bilirubin or porphyrin (or precursors).

2. PMS

SAM-e is often taken for PMS (Premenstrual Syndrome) and a more severe form PMDD (Premenstrual Dysphoric Disorder).

IV use of SAM-e

IV (Intravenous) use of SAM-e is used for depression, osteoarthritis, AIDS-related nervous system disorders, fibromyalgia, liver disease, cirrhosis, and intrahepatic cholestasis (a liver disorder in pregnant women)

SAM-e Injections

SAM-e is often injected for fibromyalgia, depression, and Alzheimer’s disease.

Effects on Digestion

TMG aids digestion, again likely because of positive methylation throughout the body.

Glycine

Glycine is the component left over when all three methyl groups have been donated from TMG.
Glycine is the smallest of the amino acids and very important for collagen formation and many other functions. Collagen, the most abundant protein in the body, is used for connective tissue: Tendons, ligaments, cartilage, skin, nails, arteries, veins, etc. Without collagen, we could not stand up, our body would be a pile of mush on the floor!
Glycine, in large doses (up to 3000 mg daily), has been found helpful for sleep and alertness. Although not recommended as a first-line supplement for sleep, it may help if other supplements like Valerian fail to work. This may explain why TMG helps induce restful sleep in some individuals.

Natural sources of TMG

TMG is normally made in the body, but not enough when there are toxins present or the diet is poor or absorption of nutrients is a problem.
TMG can come from the diet. Foods high in TMG include broccoli, quinoa, spinach, lamb, chicken, and beets. A vegetarian or vegan diet tends to be very low in TMG. Foods high in TMG are usually also high in folate, and both are methyl donors.
However, most people do not eat enough of these foods, and even eating large amounts will not provide enough TMG for optimum health.

Risk factors for low TMG

Generally, the body cannot make enough, the modern diet is poor in TMG, and the number of pesticides, chemicals, heavy metal contamination uses up all TMG available.

  • Mercury is a poison that lowers TMG production in the body, and at the same time increases the need for TMG in the body. Almost everyone is mercury toxic now, as mercury is everywhere in the environment, especially in seafood and in dental amalgam fillings
  • Copper toxicity also interferes with TMG, and most people today are toxic from copper pipes, tapware, cookware even if blood or urine tests are negative. While copper is essential for the body to build hemoglobin in blood, we need Chelated Copper from food or supplements, not metallic copper from copper pipes and cookware. Zinc deficiencies cause accumulation of copper in the body, and women have a higher risk than men. Causes headaches, female organ problems, depression, anxiety, skin conditions. Too much zinc (and/or magnesium) competes with copper for absorption, often leading to a copper deficiency.

Supplements

Supplementary TMG is helpful for most people because of low body production, low in the diet, and higher requirements in our toxic world.
TMG 1000mg 100 tablets (most popular, best value).

Stress

Stress, inflammation, inflammation and some diseases increase our need for more TMG.

Dosage of TMG

  • Women: Up to 1000 mg daily
  • Men: Up to 3000 mg daily
  • Children: Less than adults, in proportion to body weight

There are no reliable guides or tests to determine TMG dosage, but the figures above should be a good starting point.
If the sodium/potassium ratio is low, extra TMG may help.
Do not overdose, as too much TMG may lead to over-methylation, causing fatigue, nausea, hair loss, dizziness or other symptoms.
Most people have no side effects from TMG apart from feeling better, getting better sleep and having more energy.
Cautions:
Do not continue a high dose for extended periods.
Children need proportionately less TMG than adults, depending on their size and weight, but babies generally do not need TMG. Older children may need about 250 to 500 mg daily.
TMG is available as tablets, liquid capsules or crystals. Some children and the elderly may have problems with swallowing tablets. TMG has a sweet taste, so TMG crystals can be simply added to food.
Some people have problems tolerating TMG, so they may need a smaller dose. Try reducing the dose until any symptoms disappear.
People who have unresolved resentments seem to have more problems taking TMG, as an enzyme is activated which can cause anger, fear, depression or anxiety symptoms. These symptoms disappear if the dose is reduced or eliminated, but if one can tolerate the symptoms, TMG may help the person resolve their issues of conflict.
Some reports suggest that too much TMG may cause diarrhea and nausea, and may raise cholesterol levels, so those with high cholesterol should keep the level monitored.

Poor Methylation

Several factors affect poor methylation, such as:

  • Raw vegetables are considered healthy, but cooked vegetables provide more dietary methyl groups
  • Sugars in any form appear to harm correct methylation, and are bad for our health anyway
  • Fermented foods are healthy, but are problem for methylation because:
    • Some contain aldehydes (toxic to the liver), including kombucha tea, kimchi, and most fermented grains
    • They contain ferments, which are bacteria or yeasts

    Safer fermented foods, eaten in moderation, include yogurt, kefir, miso and most good quality cheeses

  • Too much animal protein in the diet can cause high methionine and reduce methylation
  • Fighting inflammation or infections consumes methyl groups, requiring more methylation
  • Heavy metal toxicity, especially copper and mercury, interfere with methyl group formation
  • High-dose niacin or niacinamide cause the body to use up methyl groups to detoxify and excrete niacin through the liver. Doses less than 50 mg daily are generally tolerated well
  • Any liver toxins will reduce formation of methyl donors, also liver detoxification pathways require methyl groups, using up more methyl groups
  • Methyl donor production seems to decrease with age, so seniors need more TMG
  • Women of child-bearing age have much better methylation than men. Men always need more TMG than women

Methylation and Cancer

Cancer increases the need for methylating agents like TMG. People often die with cancer because they cannot eliminate their toxic metals and chemicals because of poor liver methylation, so toxins accumulate until death occurs.

Hair Mineral Analysis

More TMG may be required if a hair mineral test reveals:

  • High zinc level, which may indicate presence of hidden toxic metals
  • “Four lows pattern” meaning all four electrolyte minerals low: Calcium, Magnesium, Sodium, Potassium. Indicates impaired methylation
  • High mercury, becoming more common
  • High copper
  • High levels of the other toxic metals

These results indicate long-term toxic metal exposure.

LeanMachine online supplemments

Disclaimer

LeanMachine is not a doctor, and everyone should consult with their own health professional before taking any product to ensure there is no conflict with existing prescription medication.
LeanMachine has been researching nutrition and health since 2010 and has completed many relevant studies including:
Open2Study, Australia – Food, Nutrition and Your Health
RMIT University, Australia – Foundations of Psychology
Swinburne University of Technology, Australia – Chemistry – Building Blocks of the World
University of Washington, USA – Energy, Diet and Weight
Johns Hopkins Bloomberg School of Public Health, USA – Health Issues for Aging Populations
Johns Hopkins Bloomberg School of Public Health, USA – International Nutrition
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics I
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics II
Johns Hopkins Bloomberg School of Public Health, USA – Principles of Human Nutrition
TUFTS University, USA – Nutrition and Medicine
TUFTS University, USA – Lipids/Cardiovascular Disease I and Lipids/Cardiovascular Disease II
Technical Learning College, USA – Western Herbology, Identification, Formulas
Bath University, England – Inside Cancer
WebMD Education – The Link Between Stroke and Atrial Fibrillation
WebMD Education – High Potassium: Causes and Reasons to Treat
Leiden University Medical Center, Netherlands – Anatomy of the Abdomen and Pelvis
MIT (Massachusetts Institute of Technology) – A Clinical Approach to the Human Brain
LeanMachine has now examined thousands of studies, journals and reports related to health and nutrition and this research is ongoing.

Updated 9th January 2020, Copyright © 1999-2020 Brenton Wight and BJ & HJ Wight trading as Lean Machine abn 55293601287

Protect yourself from liver damage with phosphatidylcholine

Reproduced from original article:
www.naturalhealth365.com/phosphatidylcholine-liver-damage-3239.html
by: | December 31, 2019
liver-damage
(NaturalHealth365)  Nonalcoholic fatty liver disease – defined as excess fat in the liver in the absence of chronic alcohol abuse – is fast becoming a pandemic in the United States. According to recent research, the national prevalence of NAFLD has soared from 18 percent of the population (in 1991) to an astounding 31 percent in 2012 – and death rates from chronic liver disease are on the rise as well.Fortunately, a natural nutrient known as phosphatidylcholine is showing the potential to slow and even reverse fatty liver damage, while protecting against damage from a variety of toxins.

In spite of decades of clinical trials demonstrating phosphatidylcholine’s protective effects, this lecithin-like nutrient still seems to be relatively little-known – and underappreciated – by most people.

Essential NEWS: Phosphatidylcholine makes up 65 percent of all cell membranes

In addition to functioning as the body’s major detoxifying organ, the liver also stores vitamins, assists in the absorption of nutrients, secretes hormones and metabolizes body waste and toxins into water-soluble compounds to be eliminated.

Researchers have learned that most of the life-sustaining activities performed by the liver actually occur on the membranes of the parenchymal cells (known as the “workhorses of the liver”).

Phosphatidylcholine – which is produced by the liver – is absolutely essential for the structure and function of these cells.  Although the parenchymal cells are normally protected by antioxidants such as glutathione and cysteine, exposure to environmental toxins, viruses and bacteria can deplete these protective enzymes and jeopardize levels of phosphatidylcholine (PC).

Do NOT ignore the health dangers linked to toxic indoor air.  These chemicals – the ‘off-gassing’ of paints, mattresses, carpets and other home/office building materials – increase your risk of headaches, dementia, heart disease and cancer.

Get the BEST indoor air purification system – at the LOWEST price, exclusively for NaturalHealth365 readers.  I, personally use this system in my home AND office.  Click HERE to order now – before the sale ends.

And that’s where the trouble really begins.  Protective cell membranes lose their integrity and develop holes, leading to leakage of vital enzymes and, eventually, cell death – which in turn causes inflammatory and necrotic damage to liver tissue.

In order to avoid this scenario, and to continue to carry out its life-sustaining duties, the liver must create new cell membranes – for which PC is a key ingredient.

In a groundbreaking German study conducted in 1973, researchers began to evaluate PC’s therapeutic effects on liver disease in humans – and evidence of PC’s benefits has continued to accumulate ever since.

Phosphatidylcholine can reverse alcoholic liver damage, study says

To conduct the five-year study, the team gave PC daily to 650 subjects with varying degrees of liver damage, then regularly assessed them through biopsies, blood analysis and clinical tests.

Participants’ liver disease ranged from mild to severe – and included fatty degeneration, aggressive inflammation and advanced fibrotic damage.

The subjects were first given PC both orally and intravenously – then were switched to oral supplementation at 450 to 700 mg a day.  The results were striking!

Over 50 percent of participants with mild liver damage showed “excellent” improvement – and even experienced reversal of fatty deposits.

In participants with persistent inflammation, PC returned enzyme parameters to normal after 30 days.  And, of those with the most severe and aggressive chronic inflammation, more than one-third experienced a benefit.

PC supplementation even benefited 17 percent of those with advanced liver scarring – an impressive finding in light of the fact that some of the participants had failed to benefit in the past from other treatments, including steroid drugs and milk thistle extract.

The impressed researchers concluded that PC was the “best single means” for managing liver damage – quite an endorsement!

Warning: Alcohol strips much-needed PC from cell membranes and triggers the development of a fatty liver

PC seems custom-designed to help protect the body from the harmful effects of ethyl alcohol (the type found in beer, wine and liquor).  These damaging effects include damage to mitochondria – the “power centers” of the cells – oxidative stress, antioxidant depletion and inhibition of the liver’s detoxification system.

In addition, alcohol molecules are metabolized to become acetaldehyde (the harmful toxin that is responsible for hangover misery).

Perhaps most alarmingly, alcohol dissolves phosphatidylcholine from the parenchymal cell membranes – jeopardizing their ability to metabolize triglycerides (fat) and setting the stage for inflammation and deposits of fat in the liver.

In fact, so effective is PC at metabolizing lipids that it is used in cosmetic injections to dissolve fat.  Clearly, supplementation with PC is a valuable tool in addressing liver dysfunction.

In an article published in Alternative Medicine Review, the author notes that extensive animal studies have shown that PC slows the progression of fatty liver disease and helps reduce liver fibrosis, or scarring.  And, the German study is one of many showing that PC’s fat-burning and liver-restoring effects translate into therapeutic benefits for human patients with fatty livers.

Additional studies have shown that 1,000 to 3,000 mg a day of phosphatidylcholine can protect the liver by reducing the leakage of enzymes, decreasing the harmful oxidation of fats, slowing membrane damage and preserving membrane integrity.

A liver “MVP,” phosphatidylcholine also protects against damage from medications, pollutants and viruses

Of course, alcohol is far from the only threat to liver health.

Over-the-counter and prescribed medications – including acetaminophen, aspirin, ibuprofen, antibiotics and benzodiazepines – also take a toll on the liver, as does exposure to herbicides, pesticides and electromagnetic radiation from smart phones and laptops.

Animal and clinical studies have shown that PC defends the liver against these, as well.  In one study, PC was even found to be effective against Amanita phalloides, the notorious “deathcap” mushroom.

In other research, PC helped to resolve liver damage from hepatitis A and B, while improving general well-being.  Note: In 20 percent of the PC-treated patients, the virus was found to be “inactive” – a truly encouraging result!

Support liver health with phosphatidylcholine supplementation

Phosphatidylcholine is produced in the liver, and is also found in some foods – including cage-free eggs, organic soybeans, mustard and sunflower seeds.

Clearly, supplementation could be a wise move for those dealing with fatty liver disease.

Natural healers may recommend dosages in the area of 500 mg to 3,000 mg of phosphatidylcholine a day. Of course, check first with your integrative doctor before supplementing with PC.

As a “bonus tip:” PC is not only highly bioavailable – with about 90 percent absorption over 24 hours – but it also enhances the bioavailability of other nutrients, such as flavonoids, that are taken along with it.

No doubt, researchers are hailing PC as an “effective and safe nutrient for liver damage of all levels of severity.”  And, with fatty liver disease becoming rampant in the United States, PC’s ability to reduce and prevent fatty deposits and fibrosis is certainly good news.

Editor’s note: LuvByNature Liposomal LiverLuv is my number ONE pick for supporting liver health, detoxification and glutathione levels.  Click here to order today!

Sources for this article include:

Semanticscholar.org
Naturalhealth365.com

What high blood pressure, insulin resistance and obesity are telling you about your liver health

Reproduced from original article:
www.naturalhealth365.com/obesity-fatty-liver-3202.html
by:  

(NaturalHealth365) According to the Fatty Liver Foundation, more than 100 million people in the U.S. have a fatty liver, and most of those people don’t even know it.  And with 2/3 of the population suffering with obesity … these numbers are expected to soar in the coming years.  Keep in mind, this health condition leads to millions of people developing nonalcoholic fatty liver disease, liver fibrosis plus liver cirrhosis and failure.

Here’s the point: Since most people don’t realize they have fatty liver disease, it’s critical to understand liver health, other conditions linked to liver disease, and how you can prevent it.

For example, recent studies have discovered a link between fatty liver and metabolic syndrome – which includes components like high blood pressure, abdominal obesity, and insulin resistance along with high blood sugar levels. This means that your blood pressure, blood sugar, and even your weight could be telling you a whole lot about your liver health.

The link between fatty liver, high blood pressure, obesity, and insulin resistance

Fatty liver has a strong association with obesity, a condition that is well-known for increasing your risk of dying from other diseases. Obesity, especially visceral fat around the abdomen, is a significant component of metabolic syndrome, a grouping of disorders that may include hypertension, type 2 diabetes, and dyslipidemia.

Recently, researchers have brought attention to the relationship between fatty liver and high blood pressure, as well. Experts took a look at the livers in individuals with high blood pressure that had normal liver blood tests and no risk factors for poor liver health.

Do NOT ignore the health dangers linked to toxic indoor air.  These chemicals – the ‘off-gassing’ of paints, mattresses, carpets and other home/office building materials – increase your risk of headaches, dementia, heart disease and cancer.

Get the BEST indoor air purification system – at the LOWEST price, exclusively for NaturalHealth365 readers.  I, personally use this system in my home AND office.  Click HERE to order now – before the sale ends.

Even without apparent risk factors for liver disease, an incredible 30% of these hypertension people studied also had a fatty liver. The results show a clear link between fatty liver and high blood pressure.

Interestingly, researchers discovered that while none of the subjects were overtly diabetic or obese, individuals with high blood pressure and fatty livers had higher body mass indices, insulin resistance, and glucose levels than the people who had high blood pressure without fatty liver.

The importance of early screening for nonalcoholic fatty liver disease

Generally, nonalcoholic fatty liver disease is a silent disease that presents no symptoms. Even when cirrhosis develops, there are rarely symptoms until the liver sustains so much damage that a liver transplant is needed.

For this reason, it’s essential to pay attention to other conditions linked to fatty liver disease, such as high blood pressure, insulin resistance, high blood sugar levels, and obesity. If you have any of these components of metabolic syndrome, talk to your doctor about early screening.

The Fatty Liver Foundation advocates for early screening, and new technology offers a quick, economical, and easy method for early screening known as a FibroScreen. While many insurance companies may not pay for the scan unless you’re displaying symptoms, talk to your doctor about the option of early testing if you have metabolic syndrome.

The key to preventing liver failure is early detection (and immediate changes in lifestyle), so addressing this issue early can certainly save your life.

Sources for this article include:

BMJ.com
TheClinics.com
FattyLiverFoundation.org

The Damaging Effects of Oxalates on the Human Body


Reproduced from original article:
articles.mercola.com/sites/articles/archive/2019/11/10/oxalic-toxicity.aspx

Analysis by Dr. Joseph MercolaFact Checked – November 10, 2019

STORY AT-A-GLANCE

  • Oxalic acid or oxalates are very tiny molecules that bind minerals like calcium and form crystals. It is found in a variety of seeds, nuts and many vegetables. It’s only two carbons and four oxygen molecules. It’s a highly reactive compound that is attracted to positively charged minerals
  • Oxalates not only can cause kidney stones (calcium oxalate kidney stones) but also may be responsible for a wide variety of other health problems related to inflammation, auto-immunity, mitochondrial dysfunction, mineral balance, connective tissue integrity, urinary tract issues and poor gut function
  • Oxalic acid can harm glandular function, connective tissue function, neurological function and the function of the tissues of excretion, particularly the kidneys and bladder
  • Having a damaged gut lining will increase your absorption of oxalates. An inflamed or damaged gut lining is a very common problem, thanks to frequent antibiotic use and the presence of a number of chemicals in our food supply, including glyphosate. Other plant compounds such as phytates and lectins (such as gluten) can worsen gut health and exacerbate the impact of oxalates
  • Tissue destruction, fibromyalgia and autoimmune diseases such as rheumatoid arthritis and lupus are all issues that can be related to oxalates

Sally Norton,1 who has studied nutrition and has a graduate degree in public health, is one of the leading experts on oxalate poisoning — a topic you don’t hear much about. Chances are you may never have heard about oxalates, or have any idea why they might matter.

As is often the case with experts in any health field, her expertise is an outgrowth of her personal struggles with health problems that didn’t respond to more conventional treatments, including healthy living (Norton was a vegetarian for 16 years).

“Like so many other people who are now discovering this, I was the kind of person who, no matter what I did, I could not create the vibrant robust health that I felt that I wanted, that I felt was intended for me to have.

It was just perpetual frustration, which is kind of amazing because the more you try to be healthy, the less it works — even when you’ve got a degree in nutrition from Cornell University and a degree in public health.

I worked in integrative medicine and knew all the holistic and complementary healing modalities … Here I was, the health expert who was not healthy …

The Vulvar Pain (VP) Foundation started educating people 25 years ago and making a big effort to get foods properly tested to know about oxalates in food because the story here is that we’re eating foods that are full of a toxin called oxalate …

We’re not paying attention to how this chemical’s affecting our physiology … [Oxalate] is a natural chemical that plants make, and we even make oxalate in our own metabolism.”

Chances are, if you have heard of oxalates, you’ve heard of them in relation to calcium oxalate kidney stones. A vast majority of the scientific information available on oxalate refers to this. However, while it certainly contributes to kidney stones, it can also have other detrimental health effects.

Interestingly, from the 1850s through the early 1900s, oxalate poisoning was well-recognized. Back then, it was referred to as oxalic acid diathesis. It was known to be a seasonal problem that got worse in the spring and summer, when fresh greens were available, when people’s oxalate consumption would go up.

Unfortunately, it has since gotten lost and left out of clinical science. As noted by Norton, there’s scientific evidence showing oxalic acid can harm glandular function, connective tissue function, neurological function and the function of excretion routes, particularly the kidneys.

Oxalate 101


Oxalic acid or oxalates are tiny molecules found in a variety of seeds, nuts and vegetables. It’s only two carbons and four oxygen molecules. It’s a highly reactive compound that is attracted to positively charged minerals. Norton explains:

“Calcium has a particular love of oxalate, and vice versa. The two of them seek each other out quite easily. We often see very abundantly the calcium oxalate form of oxalate. We see it in the plants. The plants form crystals and have the smaller individual ions and nanocrystals.

But they do form these bigger constructions, these kinds of plant pyramids, rocks and sticks and diamonds and things that the plants make, probably deliberately for many … plants are making use of oxalate for self-defense.

In the body, you’re going to see these other forms … A molecule that has less strong a bond — potassium oxalate, sodium oxalate and so on — those are the soluble forms. When you see oxalate in nature, you see the big calcium oxalate crystals — that’s the same thing that the kidney stone is made of. The major ingredient of the classic kidney stone is oxalate.

Unfortunately, in our parlance in medicine, we think of it as calcium … We just generalize to calcium because there are multiple types of calcium stones. But in the case of oxalate stones and oxalates causing calcification in the body, the oxalate part gets sort of dropped.

Medicine is not taught that you need the substrate to make a kidney stone. You need to provide enough oxalic acid or oxalate, soluble oxalate, the potassium oxalate, the sodium oxalates and so on. You can provide enough of that to perform this calcification in the kidneys and elsewhere in the body.

The plants that we’re eating have these oxalate crystals. The big ones just cause abrasion … They’re very small, but at the cellular level they’re quite big and abrasive. They just cause mechanical damage …

These soluble oxalates are the ones that easily — because they’re so tiny — pass through in between cells. Just with passive transport, we end up absorbing oxalates. The amount we absorb depends on a lot of factors, especially the health of our digestive tract.

Those of us with any inflammation in the digestive tract are more prone … to absorbing more of that soluble oxalate and even nanocrystals of calcium oxalate. At least 1% of calcium oxalate from food is also absorbed, in addition to the soluble oxalate.

But you see, soluble oxalate is not content being potassium oxalate. It would much rather be calcium oxalate, iron oxalate or magnesium oxalate. Right away, it starts grabbing minerals. It starts messing with mineral metabolism. It even can create bouts of acidosis.”

Advertisement

Get Up to 40% Off on Select Complete Probiotics


Conditions That Can Worsen Oxalates’ Impact

As mentioned, having a damaged gut lining will increase your absorption of oxalates. Most people, in fact, have damaged gut lining, thanks to a number of assaulting compounds and chemicals.

The presence of glyphosate in our food supply is one of these problematic compounds. If you’re not eating mostly organic food, you’re bound to be consuming glyphosate, which can wreak havoc on your gut function, as described in “Glyphosate: Pathways to Modern Diseases.”

Other gut-destroying exposures include frequent antibiotic use, which can lead to various forms of microbiome imbalance, including small intestinal bacterial overgrowth.

Some processed foods contain mucus-destroying emulsifiers. Even a number of naturally occurring plant compounds such as phytates and lectins (such as gluten) as well as the sharp oxalate microcrystals are trouble for gut health. These and other compounds found in foods can worsen gut inflammation and exacerbate the impact of oxalates by allowing oxalates easy entry into the blood stream.

Many of the foods that have become popularized in the modern diet are also high-oxalate foods, which means exposure is higher in general.

High-Oxalate Foods

Examples of high-oxalate foods include potatoes, peanuts, nuts, spinachbeets, beet greens, chocolate, blackberrieskiwifigs, black beans, buckwheat, quinoa and whole grains. Norton ate a lot of beans, soy, Swiss chard, and sweet potatoes when she was a vegetarian; these are all high oxalate foods. When she cut wheat and soy from her diet, sweet potatoes became a daily staple in her diet.

Eventually, she discovered the healing value of animal foods such as bone broth, but it took many years of painful disease before she made the connection between her arthritis and her favorite plant foods.

Nuts and seeds tend to contain high amounts of oxalates, so any seed is suspect if you’re sensitive. Pumpkin seeds, watermelon seeds, sunflower and flax are among the safest, as they contain lower amounts. Oils and fats, even when extracted from plants, are all low in oxalates.

“When you extract an oil or fat, you do not take with you the oxalates. It could have been from a peanut. The oil’s still low. Olives are pretty high, but olive oil’s low. It’s really simple. It’s not in the animal foods, and it’s not in the oils and fats. But it’s in most things that are seeds,” Norton says.

“It’s also in several green vegetables, mainly spinach, Swiss chard and beet greens. Those are really the bad ones. There are a couple of kales that are not so good.

Collards are kind of medium bad. The mixed greens that people like now … those baby mixes are loaded with little beet green leaves, little Swiss chard leaves, which are high [in] oxalates …

Certain fruits are really high: kiwi … clementine … Anjou pears, guava, figs, elderberries, apricots, blackberries, unripe avocados … Starfruit is so high it’s really dangerous.”

Signs and Symptoms of Oxalate Poisoning

Tissue destruction, fibromyalgia and autoimmune diseases such as rheumatoid arthritis and lupus are all issues that can be related to oxalates because oxalate in tissues trigger the inflammasome reactions of the body’s innate immune system.

“This reactive compound kind of trashes your basic building blocks of connective tissue,” Norton says. Oxalates also cause inflammation and interfere with your body’s natural healing and repair mechanisms that usually happen overnight while you sleep.

Needless to say, this can worsen a wide variety of ailments, and trigger just as many. Norton tells the story of her own health problems, and how she finally identified oxalates as the culprit causing them all.

“Glycoproteins are where the oxalates get stuck on cells. We tend to see oxalates keeping old injuries in place where you don’t fully recover all the way. That’s one symptom. You’ve got things that don’t completely clear up. For me, it was my feet … I was forced to leave school and go get these feet dealt with. I just could not function anymore.

I had surgery. I stayed out of school for four years because I wasn’t getting better … I was getting weird vulvar symptoms, arthritis, fatigue, difficulty focusing and cognitive problems. There are a lot of neurological neurotoxicity [effects from oxalate] that interfere with cognitive function and sleep.

Fast forward years later to 2009 when I learned about the Vulvar Pain Foundation and connected the bout of vulvar pain that I had to my diet. But it took me years more of flipping around with complete disability. I could no longer work … I basically was sofa-bound.

I had to have a hysterectomy … There was endometriosis in there. The ovaries were trashed … and I didn’t recover well from that. My endocrinologist sent me off to this sleep lab because he said, ‘You’re eating great. You look awesome by way of blood tests. But, obviously, you can’t read, function or exercise.’

I was surprised to see that my nervous system was so toxic that my brain was waking up 29 times an hour … I developed irritable bowel syndrome, and then eventually it turned into chronic constipation, which is very common amongst us oxalate-poisoned people.

Part of what’s going on there is those nerves and muscles are almost paralyzed. They’ve lost their control. Their sphincters aren’t working well. The muscle tone in the colon is not functioning well because of this constant stream of oxalates coming …

It looks like you have SIBO, or you probably do, because of all the antibiotics. Of course, … emulsifiers in our [processed] foods are eroding away the mucous layer. The mucous layer is another layer of protection that we’ve lost and increases our absorption of oxalates.”

Eventually, you may develop signs and symptoms that look very much like an autoimmune disease, such as rheumatoid arthritis or lupus. Norton realized she needed to get her gut healthy. The question was how. She’d already tried everything she could think of.

An experiment with a kiwi diet in 2013 finally made the oxalate issue hit home. Her arthritis flared up and she couldn’t sleep from the pain. At that point, it dawned on her that the kiwi — a high-oxalate fruit — and the arthritis were connected.

In about 10 days on an oxalate-free diet, all of her symptoms improved. Six months after that, her feet, which had never properly healed after her surgery, were completely fine.

Lectins and Oxalates Are a Problematic Mix

On a related note, lectins — another plant chemical — can also wreak havoc on your health, and Dr. Steven Gundry, author of “The Plant Paradox: The Hidden Dangers in ‘Healthy’ Foods That Cause Disease and Weight Gain,” strongly believes lectins are at play in many autoimmune diseases. Norton warns that together, lectins and oxalates can “gang up on you.”

“Plants have many other chemicals too. In my research, it looks like the main target of plant chemicals that are aggressive and harmful to us is the gut … Lectins are going to create that leaky damage and make you vulnerable to infection and absorbing oxalates.

Basically, these [oxalate] nanocrystals and ions are the most toxic forms. The bigger ones that later on you can see in … kidney stones, they’re actually less toxic than the little ones.

Nanocrystals are known to interfere with the charge on cells. They depolarize cell membranes and start disabling the functions of membranes, which means your mitochondria are not working. The oxalate slows down the mitochondrial ability to produce energy.

The nanocrystals of asbestos and oxalates have basically the same level of harm. It’s just that we don’t eat asbestos three times a day and call it health food.”

How Oxalates Contribute to Heart Failure

Oxalates can also contribute to heart arrhythmia, heart failure, endothelial disorders or generalized endothelial distress. Endothelial cells are the cells that line everything, including your vascular system. Oxalates floating around your vascular system can do considerable damage, causing irritation and injury to endothelial cells.

“You set up the conditions for vascular problems,” Norton says. “Oxalates are grabbing minerals. It’s taking calcium out of the blood … and probably other minerals as well. It also has the potential to take the place of the normal chelator that would hold iron in your transferrin …

What we see in people who are post-keto, where they’ve been doing the almond bread and spinach smoothies a lot (these are the kind of people who come to me — ex-vegans and ex-keto dieters), they are getting attacks of heart rates of 130, 150. They’re getting attacks of arrhythmia … A few of them get hospitalized and they’re seeing T-wave inversions … In this case, people have stopped eating the almond bread and the spinach smoothies …

Now the body is so ready to be done with the oxalate that’s gotten stuck in all these tissues that it starts removing too much at one time. Then you get localized acidosis. You get effects in the blood. You get effects in the heart rate.

We see this electrolyte disturbance, which involves continued wasting of potassium and other minerals. We have to keep re-adding these minerals. Also, it’s almost like tissue dehydration. I really like to push salt, potassium, calcium and magnesium to help manage this sort of flushing …

Diaphragm hiccups, by the way, are a bad sign … hiccups are a neurotoxicity symptom; the vagus nerve and the whole diaphragm is getting flipped up by being poisoned … The literature … shows that one of the last symptoms before the rats die or the humans die from oxalic acid poisoning is hiccups …”

Dental tartar and even dental caries are other signs of excessive oxalates. I struggled with chronic tartar buildup myself, until I learned it was related to oxalates. When clearing out oxalates you may also experience sinus pain. Your sinuses, eyes, teeth, jaw and salivary glands are all prone to oxalate buildup, as are your fingers, toes, feet and joints in general.

Do You Need to Ditch High-Oxalate Foods From Your Diet?

If you’re eating a lot of high-oxalate foods and are struggling with any kind of chronic health issue that doesn’t seem to respond to other sensible lifestyle changes and treatments, you’d be wise to give a low- or no-oxalate diet a try.

In my own case, I was eating a lot of sweet potatoes because they’re a good source of “healthy” carbs, but they are also loaded with oxalates. All potatoes are. There is no potato that’s not high in oxalates, so get rid of the potatoes. Norton offers the following advice:

“Turning this around, you have to make a decision that you’re willing to walk away from group think because everybody around you thinks that plants are so great and you need the spinach smoothies … If you’re willing to get some facts that are science-based, then I’ve got a lot of free information on my website.

The way I understand one of the major mechanisms is this something called a trigger-maintenance theory of the oxalate accumulation in the body. The body is really smart. It’s holding onto oxalates because it’s trying to protect you from that heart arrhythmia and all that vascular damage.

The nonvascular system … the body is willing to sacrifice in order to keep the vascular system well … If you’ve got too much oxalate in your blood, the other cells will deliberately hold on to it as a temporary deal …

The body’s holding on to oxalate is meant to be temporary. Every tissue that’s holding oxalate so wants it to be gone. You give it that opportunity when you stop eating oxalates. But there can be so much already onboard. If that stuff starts moving at the same time, you could release oxalate from tissues at a [toxic] level … We’ve got to be careful about how quickly and how we go about moving [oxalate out] …

There are simple things you can do to start lowering your oxalate. Pick the foods that you don’t need in your life and then eventually get down to the chocolate and cut that too …

On my website you can get a beginner’s guide2 that explains the basics and has a graphic that shows that your spinach smoothie is 20 times what your level of oxalate should be on a whole day’s intake. It has a list of the safe bet foods and the worst offender foods that you’ve got to start cutting back on and then eventually eliminating altogether …

The two main causes of disease are toxicity and nutrient deficiency. Oxalate is causing both … You’re losing both B-vitamins and minerals. It’s very toxic. It is a poison. It’s fundamentally messing with the basics of metabolism that allows tissue recovery, repair, [that] allows growth and flourishing.”

The Carnivore Elimination Diet

Norton has for several months now been doing the carnivore diet as described in “Health Effects of the Carnivore Diet,” which features my interview with Dr. Paul Saladino. Norton discusses her transition:

“I kept seeing allergy, intolerance and colon intolerance to a lot of plant foods. I had already worked my way down to eating lemon juice because citric acid … helps weaken in bonds of the [oxalate] crystals and make them quite easy to come apart.

Citric acid protects your kidneys and is a great way to dissolve kidney stones. A half a cup of lemon juice a day and a low-oxalate diet will help your kidneys release all this oxalate painlessly. You just start peeing out all your kidney problems without pain.

I was using a lot of lemon juice, four or so lemons a day, and eating coconut products and coconut water, often from fresh young coconuts, sometimes bottled or dried coconut, and very little else for like a year. It really does help the colon repair and recover. It’s such a nice elimination diet.

April 1, 2019, I dropped the lemons and a few more supplements I was taking, like vitamin E, and dropped the coconut products … I went full carnivore.

I, myself, think that the mitochondrial and metabolic damage that’s happening from the oxalates is also being promoted by PUFAs, the polyunsaturated fatty acids, which I did not have a lot in my diet.

But some of us still need some sugars in the diet to keep the mitochondria happy. I’m back to using some maple syrup and some mangoes and a little bit of carbs to keep my legs from cramping up with low muscle glycogen.

I still love a high-fat diet. I eat a lot of beef fat and pork fat. I really enjoy a meat-centered diet. I think it’s a fabulous elimination diet that can help us. Then figure out how to bring back into the diet, as much as you wish to, low-oxalate foods like lettuce, apples and coconut stuff and some rice, some blueberries … things that you may want in your diet.

There’s a whole lot of vegetables in the cabbage family that are low in oxalate, if your digestive tract likes them, [that] … have resistant starch in them and can be useful … Transitioning from a high-oxalate diet to a low-oxalate diet, maybe even all the way down to the carnivore-style elimination diet, needs to be gradual.

Because if you create a big microbiome die-off, you’re just going to feel sick from that as well. When the oxalates start coming out, that makes you feel sick. That’s another reason why we need supplements.”

Recommended Supplements for Oxalate Poisoning

Supplements recommended by Norton for those struggling with oxalate poisoning include calcium citrate, potassium citrate, magnesium citrate and potassium bicarbonate. These are all simple mineral salts that you can easily buy in bulk powders, which I recommend doing as readymade capsules contain amounts that are so low you’ll have to swallow a whole handful of pills to get the dosage you need.

If you dislike the taste of potassium bicarbonate (which has a flavor reminiscent of baking soda), you can purchase large empty capsules and make your own. Natural unprocessed salt (such as Himalayan salt) is another important “supplement.”

“Some people go through these waves of feeling ill again as their body starts pushing out oxalates because, when you stop eating oxalate, that doesn’t fix your oxalate problem in the short run, because you’re still full of oxalates …

It’s just that the acute phases that were occurring post-meal aren’t there anymore. But you’re going to have some other phases that are often circadian in nature where you have waves of not feeling good.

We want to be aware that some of what’s going on there is a form of acidosis … The combination of lemon juice and bicarbs — about a quarter cup of lemon juice and about one-eighth teaspoon of sodium bicarb and one-eighth teaspoon of potassium bicarb — makes a lovely Alka-Seltzer Gold, made with natural citric acid …”

Again, any changes you make, whether removing food items high in oxalate or adding supplements, make sure you do it slowly and incrementally. If you have a lot of oxalate in your body, too-rapid a change can shock your already fragile system, causing you to get worse rather than better.

Over time, work your way up to 1,200 milligrams of calcium citrate, about 400 to 500 mg of magnesium and 2,500 – 4,000 mg of potassium per day. The purpose of the calcium citrate is to help release oxalates from your tissues, so when looking for calcium citrate, make sure it does not have vitamin D in it, as the vitamin D encourages absorption of oxalates.

“The bicarb is wonderful because it’s not citric acid [which, for some, can irritate the gut]. It is also alkalizing, as is the citric acid and the minerals. All of this helps with alkalization. You’re replacing the minerals. You’re also providing it citric acid, which protects your kidneys and other tissues from oxalate accumulation and damage.

They’re really helpful. You want to take as much as you can tolerate, because the more the merrier when it comes to the minerals. I think general liquid mineral for a broad spectrum is really good, [and] taking [natural unprocessed] salt to help pull hydration and pull potassium back into the bones and the muscles.

A lot of us, if you get any muscle numbness, like fibromyalgia pains, that’s the potassium deficiency showing up in the muscles, where they end up in chronic rigor and you get hypoxia from the poor circulation going on there.

Once you’ve got enough potassium that will disappear completely in about five or six weeks … I have salt and potassium bicarb, potassium citrate always in my drinking water … I drink it all day long, all the time …”

If you don’t want to drink it throughout your day, Norton recommends taking a third of your daily dose at bedtime, as this is when your body is repairing and recovering and needs these nutrients most. Take another dose in the morning, and a third dose with a meal. An additional dose can be taken if you’re having an episode you think might be related to oxalate release.

More Information

Norton currently has a book in the works. Until then, the best place to find more information is her website, SallyKNorton.com. There you can find symptom lists, guidance on oxalate-elimination, low-oxalate recipes, free articles and additional interviews and talks,3 along with more details on the science behind oxalates’ devastating health effects.

For a quick look at your own intake of high oxalate foods and the signs of oxalate-related health issues, check out Sally’s Symptom and Exposure Inventory, HERE.

“If you work your way through the various tabs on my site, you will get a huge education there,” Norton says. “And then work your way … through my blog … There’s enough reading there. You’ll be busy for a while. That will really help a lot.”

 

 

Low vitamin D levels linked to poor liver and kidney function

Reproduced from original article:
www.naturalhealth365.com/vitamin-d-fatty-liver-3187.html

Low vitamin D levels linked to poor liver and kidney function(NaturalHealth365) Ideally, the entire human body ought to work together, as a harmonious system, keeping us safe from harm and pain-free – all the days of our life.  Naturally, if one part of the body doesn’t work well, it will affect other areas of the body.  Having said that, oddly enough, most people have no idea how a simple vitamin D deficiency can be influenced by poor liver and kidney function.

Whether deriving vitamin D from food or the skin, both your liver and kidneys must be working correctly.  In other words, poor kidney function, a fatty liver or other types of liver disease can result in a vitamin D deficiency, further affecting those organs and the rest of the body.

The link between poor kidney function and vitamin D deficiency

In addition, the kidneys are essential to helping the body produce vitamin D3 – which is the active form of this vitamin. They’re also critical for filtering and removing waste from your blood, maintaining proper pH, and regulating levels of chloride, sodium, bicarbonate, and potassium.

Studies have found that vitamin D levels have the potential to help predict the early signs of kidney diseaseWhen the kidneys do not function correctly, they’re unable to provide the body with enough metabolic vitamin D, eventually resulting in additional symptoms related to a deficiency.

One study published in Ethnicity and Disease discovered that patients who have chronic kidney disease have an extremely high rate of severe vitamin D deficiency as well. Deficiency becomes a cycle because, with poor kidney function, deficiency becomes exacerbated because of the kidneys reduced ability to take vitamin D absorbed by the body and convert it into the active form the body can use.

Do NOT ignore the health dangers linked to toxic indoor air.  These chemicals – the ‘off-gassing’ of paints, mattresses, carpets and other home/office building materials – increase your risk of headaches, dementia, heart disease and cancer.

Get the BEST indoor air purification system – at the LOWEST price, exclusively for NaturalHealth365 readers.  I, personally use this system in my home AND office.  Click HERE to order now – before the sale ends.

Anyone with low levels of vitamin D should also have their kidney function tested since the early stages of kidney disease often have few other symptoms.

Low vitamin D levels confirmed in people with fatty liver disease

Responsible for bile production, detoxification, synthesizing blood components, converting nutrients, and more, the liver is also an essential organ needed in the processing of vitamin D within the body.  The liver produces the form of vitamin D known as calcidiol – which is the precursor to the active form of vitamin D.

Due to impaired synthesis, studies have found that low levels of vitamin D are quite common in individuals with liver failure.

Liver disease also can impair the absorption of the vitamin.  Low levels of vitamin D, as well as bone disease, have been recognized for some time as complications of fatty liver disease.

However, studies have also confirmed low levels of vitamin D in individuals with noncholestatic (non-fatty) liver disease. In one study, more than 92% of patients with liver disease had some level of vitamin D deficiency, even in patients who were not currently in liver failure.

In many cases, fatty liver goes undiagnosed early on because it has few symptoms and may not show up in ultrasounds or liver function tests. Going forward, on a practical level, low levels of vitamin D could be a warning sign of a fatty liver and should be addressed, before it’s too late.

Editor’s noteClick here to access the Fatty Liver Docu-Class, hosted by your truly Jonathan Landsman.  This event features 33 top experts on liver health and integrative healthcare.  You’ll discover how to detoxify the body and avoid unwanted disease symptoms.

Sources for this article include:

NIH.gov
NIH.gov

Tylenol in Pregnancy Doubles Risk of Autism


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2019/11/12/tylenol-during-pregnancy-causing-autism.aspx

Analysis by Dr. Joseph MercolaFact Checked  –  November 12, 2019
tylenol during pregnancy causing autism

STORY AT-A-GLANCE

  • Abnormal hormonal exposures in pregnancy can influence fetal brain development, and research published in 2014 warned acetaminophen is in fact a hormone disruptor
  • According to that 2014 study, use of acetaminophen during pregnancy was associated with a 37% increased risk of the child being diagnosed with hyperkinetic disorder, a severe form of attention deficit hyperactivity disorder (ADHD)
  • A 2019 study found that, compared to children of mothers with the lowest acetaminophen burden, children of mothers with the greatest exposure had a 286% higher risk for ADHD and a 362% higher risk for autism spectrum disorder (ASD) by the time they were about 9 years old
  • Findings published in 2016 revealed use of acetaminophen at 18 and 32 weeks of pregnancy were associated with a 42% higher risk of conduct problems and a 31% higher risk of hyperactivity symptoms in the child
  • Another 2016 investigation found children of both sexes whose mothers used acetaminophen during pregnancy were 41% more likely to present with ADHD symptoms at age 5. Boys were also more likely to have ASD

Many view over-the-counter (OTC) drugs as safe because they don’t require a prescription. Nothing could be further from the truth. Acetaminophen, for example, (also known as paracetamol and sold under the brand name Tylenol among others) is actually one of the more dangerous drugs you can get your hands on.

Despite statistics showing acetaminophen is the leading cause of acute liver failure in the U.S.,1 most people don’t think twice before downing those pills. Acetaminophen is also found in a wide variety of products designed to treat headache, fever and cold symptoms, as well as in prescription pain medications mixed with codeine or hydrocodone.2 And, most households have more than one of the over-the-counter products, which could easily lead to overdosing.

Although it was initially hailed as a safe drug for pain, by 2013 lawsuits were piling up, citing 50,000 trips to the emergency room every year, all due to Tylenol causing liver and kidney failure.3 The grim truth is that as early as 2005 scientists already knew that “severe acetaminophen hepatotoxicity leads to acute liver failure.”4

Not only that, reports also showed that unintentional overdoses accounted for hundreds of suicide attempts, deaths and liver transplants. Along that line, statistics from national database analyses in 20065 showed that acetaminophen accounted for an estimated 56,000 emergency room visits and 26,000 hospitalizations annually. The average annual death toll from acetaminophen overdose was 458.

A number of studies have also linked acetaminophen use during pregnancy with lifelong repercussions for the child, raising their risk of developing conduct disorders, hyperactivity and autism.

Acetaminophen Use Linked to Hyperactivity in Offspring

In 2014, a study in the journal JAMA Pediatrics6 revealed that “Research data suggest that acetaminophen is a hormone disruptor, and abnormal hormonal exposures in pregnancy may influence fetal brain development.” This is a significant concern, considering many pregnant women are likely to reach for an OTC pain reliever at some point during their pregnancy.

According to that 2014 study, use of acetaminophen during pregnancy was associated with a 37% increased risk of their child being diagnosed with hyperkinetic disorder, a severe form of attention deficit hyperactivity disorder (ADHD).

Their children were also 29% more likely to be prescribed ADHD medication by the time they were 7 years old. The strongest associations were observed in mothers who used acetaminophen in more than a single trimester, and the greater the frequency of use, the more likely their child was to experience behavioral problems. As reported by Forbes at the time:7

“Acetaminophen can cross the placenta, making its way to the fetus and its delicate developing nervous system. The drug is a known endocrine (hormone) disrupter, and has previously been linked to undescended testes in male infants.

Since the maternal hormone environment plays a critical role in the development of the fetus, the authors say that it’s ‘possible that acetaminophen may interrupt brain development by interfering with maternal hormones or via neurotoxicity such as the induction of oxidative stress that can cause neuronal death.’”

Similar findings were published in 2016. This study,8 also published in JAMA Pediatrics, found use of acetaminophen at 18 and 32 weeks of pregnancy was associated with a 42% higher risk of conduct problems and a 31% higher risk of hyperactivity symptoms in the child.

When the mother used acetaminophen at 32 weeks of pregnancy, the child also had a 29% higher risk of having emotional problems and a 46% higher risk of “total difficulties.”

Advertisement

Get 44% Off on Magnesium L-Threonate 90-Day Supply


Tylenol in Pregnancy May Double or Triple Risk of Autism

A study9,10,11 published online October 30, 2019, in JAMA Psychiatry further strengthens the link between acetaminophen use and ADHD, while also noting an increased risk for autism spectrum disorder (ASD). According to the authors:12

“Prior studies have raised concern about maternal acetaminophen use during pregnancy and increased risk of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in their children; however, most studies have relied on maternal self-report …

In this cohort study of 996 mother-infant dyads from the Boston Birth Cohort, cord plasma biomarkers of fetal exposure to acetaminophen were associated with significantly increased risk of childhood attention-deficit/hyperactivity disorder and autism spectrum disorder.”

Compared to children of mothers with the lowest acetaminophen burden (first tertile, based on cord plasma biomarkers for acetaminophen), children of those in the second tertile had a 226% higher risk of being diagnosed with ADHD, and a 214% higher risk for an ASD diagnosis by the time they were about 10 years old (average age 9.8 years).

Those with the greatest (third tertile) acetaminophen burden had a 286% higher risk for ADHD and a 362% higher risk for ASD. As noted by the authors,13 their findings “support previous studies regarding the association between prenatal and perinatal acetaminophen exposure and childhood neurodevelopmental risk.”

More Evidence Against Taking Acetaminophen During Pregnancy

In addition to the studies already mentioned, a number of others have also documented this disturbing link between acetaminophen use during pregnancy and neurological problems in the children. Among them:

A 2013 study14 published in the International Journal of Epidemiology found “children exposed to [acetaminophen] for more than 28 days during pregnancy had poorer gross motor development, communication, externalizing behavior, internalizing behavior and higher activity levels” than unexposed children at age 3. Use of ibuprofen was not associated with these neurodevelopmental effects.

A 2016 Spanish investigation15,16 published in the International Journal of Epidemiology found children of both sexes whose mothers used acetaminophen during pregnancy were 41% more likely to present with ADHD symptoms at age 5. Boys were also more likely to have ASD. As noted by the authors:

“Prenatal acetaminophen exposure was associated with a greater number of autism spectrum symptoms in males and showed adverse effects on attention-related outcomes for both genders. These associations seem to be dependent on the frequency of exposure.”

Aside from a higher risk of neurodevelopmental problems, studies have also shown:

Use of acetaminophen during pregnancy may increase your risk of pre-eclampsia and thromboembolic diseases17

Taking the drug for more than four weeks during pregnancy, especially during the first and second trimester, moderately increases the risk of undescended testicles in boys18

Using acetaminophen in the third trimester increases your risk of preterm birth19

Acetaminophen After Birth Also Linked to Autism

The use of acetaminophen after birth may also lead to problems. In fact, some argue the increased risk of autism we see following childhood vaccinations may in fact be due to the inappropriate use of acetaminophen after the shots are given — not the vaccines.20

In my view, it seems irrational to give toxic injections a free pass, but acetaminophen administration could certainly make matters worse. A small preliminary study21 published in 2008 concluded “acetaminophen use after measles-mumps-rubella vaccination was associated with autistic disorder.”

Debunkers of the vaccine-autism connection point to statistics showing that, in the early 1980s, when the autism trend began its precipitously steep incline, vaccines were not only being added to the vaccination schedule, but pediatricians were also told to start using acetaminophen instead of aspirin, as aspirin had been linked to Reye’s syndrome.22

A 2017 study23 even claims “The use of acetaminophen in babies and young children may be much more strongly associated with autism than its use during pregnancy, perhaps because of well-known deficiencies in the metabolic breakdown of pharmaceuticals during early development.”

While parents give babies and infants Tylenol for numerous reasons, one instance in which Tylenol is routinely used is after childhood vaccinations, and according to research24 published in the journal Lancet in 2009, acetaminophen might actually render vaccinations less effective when administered together, which is yet another reason to avoid giving acetaminophen to your baby.

Infants who received acetaminophen right after getting a vaccination experienced lowered immune response, developing significantly fewer antibodies against the disease they were vaccinated against.

The vaccines used in the study were for pneumococcal disease, Haemophilus influenzae type b (Hib), diphtheria, tetanus, whooping cough, hepatitis B, polio and rotavirus. The authors concluded that:

“Although febrile reactions significantly decreased, prophylactic administration of antipyretic drugs at the time of vaccination should not be routinely recommended since antibody responses to several vaccine antigens were reduced.”

Understand the Risks Associated With Acetaminophen

Pregnant women are not the only ones that need to be careful in their use of this common pain reliever and fever reducer. Acetaminophen overdose is responsible for nearly half of all acute liver failure cases in the U.S.,25 and its use has also been linked to three serious skin reactions; two of which typically require hospitalization and can be fatal.

These problems can happen to anyone. A major problem is that while acetaminophen is considered safe when taken as recommended, the margin between a safe dose and a potentially lethal one is very small.

Provided you have a healthy liver and do not consume more than three alcoholic beverages a day, the recommended oral dose of acetaminophen is up to 1,000 milligrams (mg) every four to six hours, not to exceed 3 grams (3,000 mg) per day.26 As noted by U.S. San Diego Health:27

“To appreciate how easy it is to exceed the safe limit, consider that one extra strength Tylenol tablet contains 500 mg of acetaminophen. Take two tablets at a single dose three times a day and you are at the maximum recommended dose.

If you then inadvertently consume an acetaminophen-containing allergy medication or cold medication in addition, you risk damaging your liver … The key is to be aware of how much acetaminophen you are consuming.”

What’s more, research28 has shown taking just a little more than the recommended dose over the course of several days or weeks (referred to as “staggered overdosing”) can be riskier than taking one large overdose. So, in summary, please be aware that your risk of severe liver injury and/or death increases if you:

  • Take more than one regular strength (325 mg) acetaminophen when combined with a narcotic analgesic like codeine or hydrocodone.
  • Take more than the prescribed dose of an acetaminophen-containing product in a 24-hour period.
  • Take more than one acetaminophen-containing product at the same time — Make sure to read the list of ingredients on any other over-the-counter (OTC) or prescription drug you take in combination.
  • Drink alcohol while taking an acetaminophen product — Research29,30 suggests acetaminophen increases your risk of kidney damage by 123% if taken with alcohol, even if the amount of alcohol is small.

Why You Should Keep NAC in Your Medicine Cabinet

Given their health risks, I generally do not recommend using acetaminophen-containing drugs for minor aches and pains. There are many other ways to address acute and chronic pain that do not involve taking a medication. For a long list of pain-relieving alternatives, please see this previous article.

That said, pain relievers like acetaminophen do have their place. Post-surgical pain, for example, or other severe pain may warrant its temporary use. For those instances, I recommend taking it along with N-acetyl cysteine (NAC), which is the rate-limiting nutrient for the formation of the intracellular antioxidant glutathione.

It is believed that the liver damage acetaminophen causes is largely due to the fact that it can deplete glutathione, an antioxidant compound secreted by your liver in response to toxic exposure. Glutathione also helps protect your cells from free radical damage.

NAC is the standard of care in cases of acetaminophen overdose, approved in 1985 by the FDA as an antidote for acetaminophen toxicity.31 Mortality due to acetaminophen toxicity has been shown to be virtually eliminated when NAC is promptly administered. So, whether you are taking Tylenol in prescription or over-the-counter form, I strongly suggest taking NAC along with it.

Keep in mind, however, that there’s no data showing whether taking NAC would ameliorate the autism or ADHD risk for pregnant women, so if you’re pregnant, I would recommend just avoiding acetaminophen. If you absolutely need an OTC pain reliever, ibuprofen appears to be a safer choice. The same caveat for lack of data goes for infants.

Tips for a More Toxin-Free Pregnancy

I believe it’s imperative to be aware of, and abstain from, as many potential neurotoxins as possible during pregnancy to protect the health of your child. Our environment is saturated with such a wide variety of toxins, and you may not be able to defend yourself against each and every one of them, but you do have a great degree of control within your own immediate household.

The food and drinks you ingest, and the household, personal care and medical products you opt to use during pregnancy can have a distinct impact on your child’s development and long-term health.

ADHD and autism have both skyrocketed in prevalence the past few decades, signaling that something is going terribly wrong. Our environment is becoming overly toxic, and children are paying the price for our chemical-laden lifestyles. OTC drugs like acetaminophen are part of this toxic burden that infants have to contend with.

Avoiding any and all unnecessary drugs is one aspect you have a large degree of control over. Below are several more. Rather than compile an endless list of what you should avoid, it’s far easier to focus on what you should do to lead a healthy lifestyle with as minimal a chemical exposure as possible. This includes:

As much as you’re able, buy and eat organic produce and grass fed, pastured animal foods to reduce your exposure to agricultural chemicals like glyphosate. Steer clear of processed, prepackaged foods of all kinds. This way you automatically avoid pesticides, artificial food additives, dangerous artificial sweeteners, food coloring, MSG and unlabeled genetically engineered ingredients.

Also avoid conventional or farm-raised fish, which are often heavily contaminated with PCBs and mercury. Wild caught Alaskan salmon is one of the very few fish I still recommend eating, as well as small fatty fish like anchovies, sardines, mackerel and herring. If you don’t eat these on a regular basis, consider taking a krill oil supplement to optimize your omega-3 level.

Store your food and beverages in glass rather than plastic, and avoid using plastic wrap and canned foods to avoid exposure to plastic chemicals known to disrupt endocrine function.
Install an appropriate water filter on all your faucets (even those in your shower or bath).
Only use natural cleaning products in your home.
Switch over to natural brands of toiletries such as shampoo, toothpaste, antiperspirants and cosmetics. The Environmental Working Group has a great database32 to help you find safer personal care products. I also offer one of the highest quality organic skin care lines, shampoo and conditioner, and body butter that are completely natural and safe.
Avoid using artificial air fresheners, dryer sheets, fabric softeners or other synthetic fragrances. Relinquish the idea that fragrance equals “clean.” It doesn’t. Clean laundry need not smell like anything at all.
Replace your nonstick pots and pans with ceramic or glass cookware to avoid toxic PFOA chemicals.
When redoing your home and/or shopping for baby items, look for “green” toxin-free alternatives. Avoid plastic toys, especially teething toys, and make sure items like mattresses, car seats and nursing pillows do not contain toxic flame retardant chemicals.
Replace your vinyl shower curtain with one made of fabric, or install a glass shower door. Most all flexible plastics, like shower curtains, contain dangerous plasticizers like phthalates.
Avoid spraying pesticides around your home or insect repellants that contain DEET on your body. There are safe, effective and natural alternatives.
 Sources and References

Health Benefits of MSM — A Powerful Sulfur Donor


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2019/10/14/msm-health-benefits.aspx

Analysis by Dr. Joseph Mercola – Medically reviewed by Dr. Stephanie Seneff
Fact Checked – October 14, 2019
msm health benefits

STORY AT-A-GLANCE

  • Sulfur is the third most abundant mineral in your body and plays important roles in many bodily processes, including metabolism and detoxification
  • Sulfur bonds are required for proteins to maintain their shape, and these bonds determine the biological activity of the proteins. Sulfur is also required for the proper structure and biological activity of enzymes
  • Sulfur is crucial for healthy liver function and the prevention of liver disease. A derangement in sulfur amino acid metabolism is found even in mild forms of liver disease
  • Excellent sources of sulfur include homemade bone broth, organic pastured eggs, grass fed meats, seafood, cruciferous vegetables and alliums like onions and garlic. Sulfur can also be obtained through supplementation with MSM and/or by taking Epsom salt baths
  • MSM is widely used in the treatment of pain, especially pain associated with arthritic conditions. Research has shown it can significantly decrease pain and improve physical function in patients with osteoarthritis of the knee

Sulfur is a somewhat “forgotten” nutrient you don’t hear mentioned very often, but it’s very important for optimal body function and health. You get most of your sulfur from certain proteins in your diet, specifically the amino acids methionine, cysteine, cystine, homocysteine, homocystine and taurine.1

Of these, the two most important sources are methionine and cysteine. Methionine is an essential amino acid, which means it cannot be synthesized by your body and must be supplied through your diet. Cysteine is conditionally essential, because it can be synthesized from methionine but not from inorganic forms of sulfur.2

Neither of these primary sulfur-containing amino acids is stored in your body per se, although glutathione is a key storage form for sulfur.3 Glutathione is composed of three amino acids: cysteine, glutamate and glycine, and is your body’s most potent antioxidant.

Glutathione also keeps many other antioxidants performing at peak levels, and cysteine availability is thought to be a rate-limiting factor for glutathione synthesis.4

While sulfur is found in many foods, sulfur deficiency may still be quite common5 — in part due to sulfur deficiency in crops,6 and in part due to low consumption of sulfur-rich foods7 such as leafy greens, cruciferous veggies, alliums8 such as garlic and onions, seafood, grass fed meats and organic pastured eggs.

Frequent use of drugs that require sulfur for excretion and/or detoxification can also contribute to an inadequate sulfur status. Acetaminophen is one such example.9 A vegan diet can also put you at increased risk for sulfur deficiency, because plant-based foods contain fewer sulfur-containing amino acids than animal-based foods.10

The Importance of Sulfur

According to Stephanie Seneff, Ph.D., who has written several papers11,12,13,14 on sulfur and sulfur metabolism and its role in human disease, sulfur plays a role in many biological processes, including metabolism15 and the sulfonation of hormones,16 and deficiency appears to play a role in a wide range of health problems and diseases, including:

  • Obesity
  • Heart disease
  • Chronic fatigue syndrome
  • Alzheimer’s disease
  • Autism17

Required in the creation of connective tissues such as cartilage, tendons and ligaments, sulfur is also essential for healthy joints, and deficiency has been linked to joint pain and joint-related diseases.18 Other benefits, uses and sources are also noted in the paper “Sulfur in Human Nutrition and Applications in Medicine”:19

“Methylsulfonylmethane (MSM), a volatile component in the sulfur cycle, is another source of sulfur found in the human diet … Organic sulfur, as SAAs [sulfur-containing amino acids], can be used to increase synthesis of S-adenosylmethionine (SAMe), glutathione (GSH), taurine, and N-acetylcysteine (NAC).

MSM may be effective for the treatment of allergy, pain syndromes, athletic injuries, and bladder disorders.

Other sulfur compounds such as SAMe … taurine, glucosamine or chondroitin sulfate, and reduced glutathione may also have clinical applications in the treatment of a number of conditions such as depression, fibromyalgia, arthritis, interstitial cystitis, athletic injuries, congestive heart failure, diabetes, cancer, and AIDS.”

Advertisement

Get Over 40% Off on Select Items Daily


Sulfur 101

As explained by the featured study above, sulfur is the third most abundant mineral in your body, based on percentage of total body weight.20 Sulfur bonds are required for proteins to maintain their shape, and these bonds determine the biological activity of the proteins.

For example, hair and nails consist of a tough protein called keratin, which is high in sulfur, whereas connective tissue and cartilage contain proteins with flexible sulfur bonds, giving the structure its flexibility.

With age, the flexible tissues in your body tend to lose their elasticity, leading to sagging and wrinkling of skin, stiff muscles and painful joints. A shortage of sulfur likely contributes to these age-related problems.

In addition to bonding proteins, sulfur is also required for the proper structure and biological activity of enzymes. If you don’t have sufficient amounts of sulfur in your body, enzymes cannot function properly.

A cascade of health problems may thus ensue, since your metabolic processes rely on biologically active enzymes. You can learn more about this in “Enzyme Fundamentals.” Sulfur also plays an important role in:

Your body’s electron transport system, as part of iron/sulfur proteins in mitochondria, the energy factories of your cells21
Synthesizing important metabolic intermediates, such as glutathione — one of the most important antioxidants that your body produces — SAMe, taurine and NAC22
Detoxification23 — Without sulfur, glutathione (your body’s built-in detoxifier) is rendered ineffective
Thiamine (vitamin B1) and biotin (B7) conversion, which in turn are essential for converting carbohydrates into energy
Proper insulin function24 — The insulin molecule consists of two amino acid chains connected to each other by sulfur bridges, without which the insulin cannot perform its biological activity25
Glucose metabolism — One hypothesis26 is that if a sufficient amount of sulfur is available, it will act as a decoy to glucose, effectively diverting it to reduce the sulfur rather than glycating and causing damage. This would have the beneficial effect of reducing chronic inflammation, as sugar (glucose) is highly inflammatory and wreaks havoc in your body

Sulfur for Liver Health

Sulfur is also crucial for healthy liver function and the prevention of liver disease. As noted in one study,27 “a derangement in sulfur amino acid metabolism, possibly located at various steps along the trans-sulfuration pathway” is found even in mild forms of liver disease.

Part of its influence on your liver has to do with its influence over glutathione. As noted in the 2015 paper,28 “Metabolism of Sulfur-Containing Amino Acids in the Liver: A Link Between Hepatic Injury and Recovery”:

“The transsulfuration pathway is connected to the production of glutathione (GSH), which has potent antioxidant capacity in the liver. Accumulating data show that GSH depletion renders the liver vulnerable to oxidative stress and prone to progression of liver disease.”

Similarly, the journal Nutrients reports that MSM has been shown to attenuate “cytokine expression in vivo for induced colitis … and liver injury,” and that MSM has also been shown to have a beneficial effect on liver cancer.29

Another crucial nutrient for liver health and the prevention of chronic liver disease, including nonalcoholic fatty liver disease, is choline,30 detailed in “Choline Is Crucial for Liver Health.”

MSM for Osteoarthritic Knee Pain

Methylsulfonylmethane (MSM) is known as a sulfur donor, being 34% elemental sulfur by weight.31 Many of the benefits of MSM supplementation are related to its ability to reduce inflammation, regulate the balance of reactive oxygen species and antioxidant enzymes,32 and modulate your immune response.33

As a supplement, MSM is widely used in the treatment of pain, especially pain associated with arthritic conditions. One clinical trial34 found that people with osteoarthritis of the knee who took 3 grams of MSM twice a day for 12 weeks experienced significantly decreased pain and improved physical function, compared to a placebo.

Another randomized double-blind placebo-controlled study35 found patients with mild to moderate osteoarthritis benefited from oral glucosamine and MSM, both individually and in combination. Here, the treatment groups received 500 milligrams (mg) of glucosamine and/or 500 mg of MSM three times a day for 12 weeks. According to the authors:36

“Glucosamine, MSM and their combination produced an analgesic and anti-inflammatory effect in osteoarthritis. Combination therapy showed better efficacy in reducing pain and swelling and in improving the functional ability of joints than the individual agents.

All the treatments were well tolerated. The onset of analgesic and anti-inflammatory activity was found to be more rapid with the combination than with glucosamine. It can be concluded that the combination of MSM with glucosamine provides better and more rapid improvement in patients with osteoarthritis.”

Sulfur’s Role in Heart Disease

In 2011, I interviewed Seneff about the influence of sulfur on health and disease. I’ve included that interview above for your convenience. In it, Seneff discusses the crucial connections between sulfur, cholesterol and vitamin D.

Her research suggests heart disease may actually be related to cholesterol sulfate deficiency, and in the interview, she explains how elevated LDL (low-density lipoprotein) cholesterol is a sign of this deficiency.

To summarize, high levels of LDL cholesterol is your body’s way of compensating for cholesterol sulfate deficiency. When LDL is turned into plaque, blood platelets inside the plaque produce cholesterol sulfate, which your heart and brain need for optimal function.

Seneff also explains why lowering LDL with statins can lead to heart failure. Essentially, by elevating LDL, your body is protecting itself from the harmful effects of cholesterol sulfate deficiency. When you simply remove the LDL, you remove this “backup” mechanism aimed at keeping your heart going strong. As a result, heart failure becomes a distinct possibility.

That said, high LDL is correlated with cardiovascular disease, so the question then becomes: How can your body produce cholesterol sulfate without having to create harmful LDL?

Under normal, healthy conditions, your skin synthesizes both cholesterol sulfate and vitamin D3 sulfate when exposed to sunlight. These two sulfated sterols are water soluble and can travel freely in your bloodstream.

If you have sufficient amounts of cholesterol sulfate in circulation, your body does not need to produce more cholesterol-transporting LDL. This results in less plaque buildup in the arteries of the heart, because cholesterol sulfate is plentiful.

In essence, sensible sun exposure may be an important part of heart and cardiovascular health. In fact, studies have shown that those who live in countries with abundant sunlight have a lower risk to heart disease. Vitamin D3 supplements, on the other hand, are unsulfated. This is a significant drawback, as the unsulfated form needs LDL as a vehicle of transport.

Seneff believes that vitamin D is basically a signaling molecule that informs the tissues that there is an abundant supply of cholesterol sulfate, and cholesterol sulfate is the real beneficial product of sunlight exposure to the skin. Her suspicion is that the oral nonsulfated form of vitamin D is unlikely to provide the same benefits as the vitamin D created in your skin from sun exposure, since it is not accompanied by cholesterol sulfate, and therefore provides a false signal.

Sulfur Intolerance May Be a Sign of Toxicity

As mentioned earlier, sulfur-rich foods37 include leafy greens, cruciferous veggies, alliums,38 seafood, grass fed meats and organic pastured eggs. Another excellent source, and perhaps the best one, is homemade bone broth made from organically raised animals.

Either drink the broth regularly, or use it for soups and stews. Connective tissues are sulfur-rich, and when you slow-cook the bones, you dissolve these nutrients out of the bone and into the water.

If you have poor tolerance for foods high in sulfur, it may be an indication of an overgrowth of sulfur-reducing bacteria in your gut. These bacteria, such as Desoulfovibrio and Bilophila wadsworthia, produce hydrogen sulfide gas from sulfur-based food sources, which can destroy the gut lining and cause gastrointestinal discomfort.

A defect in the enzyme that oxidizes sulfur to sulfate, called sulfite oxidase, will lead to an overgrowth of these sulfur-reducing bacteria, and toxic chemical exposures may disrupt sulfite oxidase.

Furthermore, these bacteria also convert mercury to a toxic organic form called methyl mercury. When sulfite oxidase is deficient, mercury cannot be converted to mercury sulfate, which is the nontoxic form of mercury that can be excreted by the body. Thus, disruption of sulfite oxidase results in impaired sulfation capacity and increased mercury toxicity.

Other food additives such as food dyes can also exacerbate problems in your phenol sulfur-transferase (PST) sulfation pathway by suppressing PST enzyme activity. Sulfation is a critical step in detoxification of toxic phenols.

To address this situation, it’s recommended you initially go on a low-sulfur diet and reduce your toxic exposure by eating organic and avoiding household toxins of all kinds.

As your toxicity level is reduced, you can start adding sulfur-rich foods back into your diet, one at a time. Next, it’s important to enhance your body’s detoxification process by supplying more sulfate, either through diet or supplementation.

How to Boost Your Sulfur Intake — Diet and Supplementation

Aside from sulfur-rich foods, sulfur can also be obtained through supplementation with MSM. You can learn more about MSM in my interview with Rod Benjamin.

Benjamin is the director of technical development for Bergstrom Nutrition, the largest producer of the highest quality MSM produced by distillation purification. In his interview, we discuss suggested dosages and how to identify a high-quality supplement.

The sulfur-containing amino acids cysteine and taurine can also be used, both of which are available in supplement form. The supplement form of cysteine is NAC, the benefits of which I expounded on in “The Many Benefits of NAC — One of the Most Important Supplements You’ve Likely Never Heard Of.”

Another excellent source of sulfur is taking regular Epsom salt baths. Epsom salt (magnesium sulfate) is made up of magnesium, sulfur and oxygen. While most of the benefits associated with Epsom salt baths relates to magnesium39 — such as improved sleep, stress reduction and reduced pain and muscle cramping — its sulfur content is also important for health.

Epsom salt baths are often preferable if you’re toxic, as the sulfur in Epsom salt is readily available to your body without having to be converted. As a general recommendation, use 1 to 2 cups of Epsom salt to a tub of water. The warmer the water, the more of the salt will be dissolved, and the more your body will be able to absorb as the heat opens your pores.

If you experience a negative reaction, such as irritability or hyperactivity, decrease the amount used and incrementally increase the amount based on your tolerance. Alternatively, use 1 part Epsom salt to 2 parts water for a foot bath. Soak your feet for about 30 minutes.

Toxicity data shows MSM is extremely safe and can be taken at high doses. As noted in the journal Nutrients, “As a Generally Recognized As Safe (GRAS) approved substance, MSM is well-tolerated by most individuals at dosages of up to 4 grams daily,”40 although toxicity studies have reported no observed adverse effects up to a level of 5 grams per kilo per day.41

That said, potential side effects at higher doses include intestinal discomfort, ankle swelling and skin rashes. These are likely detoxifying effects that can typically be mitigated or minimized by cutting back on the initial dosage and slowly working your way up.

 Sources and References

Acetaminophen warning: A leading cause of acute liver failure

Reproduced from original article:
https://www.naturalhealth365.com/acute-liver-failure-3093.html
by:
 

acute-liver-failure-warning

(NaturalHealth365) In an ideal world, the United States Food and Drug Administration (FDA) would always function in the best interests of the consumer. However, the sad truth is that the FDA often behaves as though it is in the back pocket of the big pharmaceutical companies and their financial interests.

In fact, there’s no better example than the case of the over-the-counter pain reliever acetaminophen, a drug that causes an array of health issues and problems – yet is still on store shelves today.

A dangerous drug connected with many liver-related health problems

Acetaminophen causes an alarming number of cases of liver damage, acute liver failure and death each year, to the tune of 26,000 hospitalizations, 56,000 emergency room visits, 100,000 calls to poison control centers, and over 450 deaths. Even when taken at the recommended doses, acetaminophen can still cause major problems; however, it’s a very profitable drug – which seems to be fueling the lack of emphasis on these risks.

The risks are even worse for those who drink three or more alcoholic beverages per day.  Taking even less than the daily recommended dose of acetaminophen for issues such as gastroenteritis can cause serious health risks; however, despite many reports of the dangers of using acetaminophen, the products don’t include sufficient warnings about these dangers.

The dangers associated with a lack of consumer awareness

Nearly half of all acetaminophen overdoses are unintentional and occur either when people lose track of how much they are taking or when more is taken because pain is not relieved by the recommended dose. Taking acetaminophen, while taking other medications, is another way that people can accidentally harm to themselves.

At over 100,000 per year, acetaminophen is the cause of most of the total calls to U.S. poison control centers, annually.  It also causes more acute liver failure cases than all other medication types combined.

Do NOT ignore the health dangers linked to toxic indoor air.  These chemicals – the ‘off-gassing’ of paints, mattresses, carpets and other home/office building materials – increase your risk of headaches, dementia, heart disease and cancer.

Advertisement:
Get the BEST indoor air purification system – at the LOWEST price, exclusively for NaturalHealth365 readers.  I, personally use this system in my home AND office.  Click HERE to order now – before the sale ends.

While millions do take acetaminophen without an immediate incident, experts are alarmed at the significant number of people that experience serious health problems.  Keep in mind, like all medications, there is a bioaccumulative effect that must be considered a risk.

How to protect the public from needless drug-related injuries and death

While it’s clear that overuse of acetaminophen can lead to liver issues, acute liver failure and even death, you’d hardly know it from reading the label.  An alarming number of issues also arise in people who are malnourished and take acetaminophen without adequate levels of glutathione in their bloodstream – an antioxidant the liver needs to metabolize acetaminophen.

However, as you would probably expect, this fact about glutathione is not emphasized on acetaminophen labels, either.

One of the main complaints about over-the-counter acetaminophen is that its packaging has incomplete or missing warnings against the possible dangers of the drug. Experts believe that risk information about mixing acetaminophen with alcohol and other medications (including those containing acetaminophen), using it after not eating, and warnings against overuse should be made much more clear.

Despite widespread alarm and calls for more safety measures as well as educational campaigns, the FDA continues to delay taking action to help protect the public from acetaminophen risks.  Bottom line: it’s up to you – as the health-conscious consumer – to educate yourself about the risks associated with acetaminophen toxicity and find safer alternatives for pain relief.

Sources for this article include:

Lifeextension.com
NIH.gov
NEJM.org

LeanMachine comment: Acetaminophen in the USA is exactly the same as Panadol, Paracetamol and similar names in Australia. Dis drug, marketed as “Safe and effective” is neither safe nor effective, and has proven links to Autism – see my article on Autism Spectrum Disorder. LeanMachine uses supplements of L-Glutathione (reduced form) regularly and has not had a cold or flu or even a headache in 10 years, or any need to take pain relievers. Watch for my upcoming pain article.

Cracking the Cholesterol Myth: How Statins Harm The Body and Mind

© 26th August 2019 GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here www.greenmedinfo.com/greenmed/newsletter

This article is copyrighted by GreenMedInfo LLC, 2019

Cracking the Cholesterol Myth: How Statins Harm The Body and Mind

The chemical war against cholesterol using statin drugs has been wrongly justified through statistical deception and the ongoing cover up of over 300 adverse health effects documented in the biomedical literature.

Better safe than sorry, right? This is the logic that defines the grasp that the pharmaceutical company has on our psyche. Perhaps your mother, father, brother, and boyfriend have been recommended cholesterol-lowering medication, just to help hedge their bets around a possible chest-clutching demise. In fact, recent guidelines have expanded the pool of potential statin medication recipients, so that there are very few of us who seem to be walking around with acceptable levels of artery clogging sludge.

But how is it that drug companies got a foothold? How have they convinced doctors that their patients need these medications, and need them now? They are banking (literally) on the fact that you haven’t brushed up on statistics in a while.

It turns out that a common sleight of hand in the medical literature is the popularization of claims around “relative risk reduction” which can make an effect appear meaningful, when the “absolute risk reduction” reveals its insignificance.  In this way, 100 people are treated with statin medications to offer 1 person benefit, and the change from a 2% to a 1% heart attack rate is billed a 50% reduction rather than a 1% improvement, which is what it actually is.

Perhaps this would still qualify as better safe than sorry if these medications weren’t some of the most toxic chemicals willfully ingested, with at least 300 adverse health effects evident in the published literature so far, with at least 28 distinct modes of toxicity, including:

Beyond the known fact that statin drugs deplete the body of two essential nutrients: coenzyme Q10 and selenium, they are also highly myotoxic and neurotoxic. Because the heart is one of the most nerve-saturated muscles in the human body, these two modes of toxicity combined represent a ‘perfect storm’ of cardiotoxicity – a highly ironic fact considering statin drugs are promoted as having ‘life-saving’ cardioprotective properties.

powerful expert review by Diamond and Ravnskov decimates any plausible indication for these cholesterol-lowering agents, giving full consideration to the above mentioned side effects.

They plainly state:

“Overall, our goal in this review is to explain how the war on cholesterol has been fought by advocates that have used statistical deception to create the appearance that statins are wonder drugs, when the reality is that their trivial benefit is more than offset by their adverse effects.”

The Cholesterol Meme

It’s tempting to look the number one killer of Americans in the eye, and say, “WHO did this? Who is responsible?” It is also consistent with American perceptions of health and wellness to demonize a natural and vital part of our physiology rather than look at lifestyle factors including government subsidies of inflammatory food products.

Not only is low cholesterol a problem, but it puts an individual at risk for viral infection, cancer, and mental illness because of the vital role that lipids play in cell membrane integrity, hormone production, and immunity.

A broadly toxic xenobiotic chemical, statin medications have only been demonstrated to be of slight benefit by statistical manipulation. For example, Diamond and Raynskov elucidate that:

  • The JUPITER trial of Crestor vs placebo resulted in increased fatal heart attacks in the treatment group which were obscured by combing fatal and nonfatal infarctions.
  • In the ASCOT trial was used to generate PR copy boasting Lipitor’s 36% reduction of heart attack risk, a figure arrived at through use of relative risk reduction from 3 to 2%.
  • The HPS study has 26% drop out rate prior to the beginning of the trial (which also demonstrated a 1% improvement with treatment), so that those with significant side effects were functionally excluded from the study.

While no study has ever shown any association between the degree of cholesterol lowering and beneficial outcomes described in terms of absolute risk reduction (likely because they would be perceived as insignificant), the adverse effects are not only always presented in these terms, but are also minimized through the technique of splitting common side effects up into multiple different categories to minimize the apparent incidence.

These side effects are real and common and include “increased rates of cancer, cataracts, diabetes, cognitive impairment and musculoskeletal disorders”.  Their paper focuses on three primary adverse effects, all of which  are likely to land you in the “sorry to have thought I would be better safe than sorry” category.

Cancer

In at least four trials, statistically significant increases in cancer incidence was found, and handily dismissed by all authors as insignificant because they claimed “no known potential biological basis” is known.  This may be because the authors are still thinking of cancer as a genetic time bomb that has nothing to do with mitochondrial dysfunction, loss of lipid integrity, or environmental exposures.

With statistically significant increases in cancer incidence and deaths, in some trials, the minimal cardiovascular benefit is far eclipsed by the cancer mortality. In one of the only long-term trials, there was a doubling of the incidence of ductal and lobular breast cancer in women taking statins for more than ten years. One of many reasons that women should never be treated with these medications.

Myopathy

As one of the more well-known side effects of statins, muscle breakdown and associated pain, or myopathy has also been obscured in the literature.  Despite an incidence up to 40% in the first months of treatment, researchers only catalogue patients who had muscular symptoms in addition to elevations in a blood measure called creatine kinase (CK) at ten times normal for two measures (not 9.9, not 8, and not one measure).

In fact, a 2006 study in the Journal of Pathology found that statin therapy induces ultrastructural damage in skeletal muscle in patients without myalgia,” indicating that statin-associated muscle damage may be a universal, albeit mostly subclinical problem for the millions put on them.

Central Nervous System Dysfunction

Linked to suicide in men, depression including postpartum, and cognitive dysfunction, low cholesterol is not a desirable goal for the average psychiatric patient, aka half of the American population.

It turns out that 25% of the total amount of cholesterol found in the human body is localized in the brain, most of it in the myelin sheath that coats and insulates the nerves:

 “It has been estimated that up to 70% of the brain cholesterol is associated with myelin. Because up to half of the white matter may be composed of myelin, it is unsurprising that the brain is the most cholesterol-rich organ in the body. The concentration of cholesterol in the brain, and particularly in myelin, is consistent with an essential function related to its membrane properties. “[i]

The cell membrane, specifically, is highly vulnerable to damage by statins:

“The cell membrane is an 8 nanometer thick magical pearly gate where information, nutrients, and cellular messengers are trafficked through protein gates supported of phospholipids and their polyunsaturated fatty acids. Cholesterol and saturated fat provide essential rigidity in balance with other membrane components. Without them, the membrane becomes a porous, dysfunctional swinging gate. In a self-preservational effort, cholesterol supports production of bile acids, integral to the breakdown and absorption of consumed essential dietary fats.” Source

By extension, behavioral and cognitive adverse effects may be the manifestation of this fat-based interference.  Diamond and Ravnskov state:

“A low serum cholesterol level has also been found to serve as a biological marker of major depression and suicidal behavior, whereas high cholesterol is protective [54–57]. In a study by Davison and Kaplan [58], the incidence of suicidal ideation among adults with mood disorders was more than 2.5-times greater in those taking statins. Moreover, several studies have shown that low cholesterol is associated with lower cognition and Alzheimer’s disease and that high cholesterol is protective.”

review article called Neuropsychiatric Adverse Events Associated with Statins: Epidemiology, Pathophysiology, Prevention and Management discusses the state of the literature around the intersection between mental health and cholesterol control. Despite generally dismissing a strong signal for concerning psychiatric adverse events, the article seems to conclude the following:

  • Severe irritability, homicidal impulses, threats, road rage, depression and violence, paranoia, alienation, and antisocial behavior; cognitive and memory impairments; sleep disturbance; and sexual dysfunction have all been reported in case series and national registries of those taking statin medications.  Sound like the laundry list of rapidly spoken side effects at the end of a drug commercial? To anyone with a history of or current psychiatric symptoms, the role of these now ubiquitous medications should be appreciated.
  • The signal for lipophilic statins – simvastatin and atorvastatin – was stronger which makes mechanistic sense since these medications penetrate the brain and brain cholesterol deficiency has been implicated in bipolar, major depression, and schizophrenia.

Of course, none of these findings nor their suppression should be surprising because there is no pharmaceutical free lunch, and because Americans are so accustomed to interfacing with human health through the lens of a one pill-one ill model. We are yanking on that spider web and expecting only one thread to pull out.  This perspective would be less disturbing if it didn’t serve as the foundation for medical practice, determined by boards such as the American College of Cardiology and The American Heart Association , the majority of whom have extensive ties to the pharmaceutical industry. An industry that has paid out 19.2 billion dollars for civil and criminal charges in the last 5 years alone.

So, the next time you hear of a doctor recommending a cholesterol-lowering intervention, tell him you’ll take that 1% risk and spare yourself cancer, cognitive dysfunction, myopathy, and diabetes. And then go have a 3 egg omelette WITH the yolks.

Originally published: 2015-02-27

Article updated: 2019-08-26

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.