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When LeanMachine went to school in the 1950’s, mental health was almost unheard of. Now almost everyone has some sort of mental health problem.
The answer is nutrition, Vitamin D3, and elimination of toxins.

 

TMG Benefits

Written by Brenton Wight, Health Researcher, LeanMachine
Copyright © 1999-2020 Brenton Wight, LeanMachine
This site is non-profit, existing only to help people improve health and immunity
Updated 16th June 2020

TMG (Trimethylglycine) is a powerful nutrient, much like a vitamin, functioning as methyl donor, anti-oxidant, anti-inflammatory, energy booster, toxin remover, immune booster and more.
Also called betaine (first isolated from sugar beets) but different from Betaine Hydrochloride.

TMG the Methyl Donor

The TMG molecule comprises three methyl groups (CH3) joined to one molecule of glycine (C2H5NO2). The benefit of TMG is that it releases easily one, two, or all three of the methyl groups.
Releasing one methyl group then leaves behind DMG (Dimethylglycine) which is just TMG with only two methyl groups. Releasing all methyl groups leaves just Glycine, which is the smallest molecule of all of the amino acids, which allows it to go almost anywhere in the body, including crossing the blood-brain barrier.
DMG is considered a B-complex vitamin, shown to help:

  • Behaviour and speech in autistic children and adults
  • ADHD (Attention Deficit-Hyperactivity Disorder)
  • Neurological function
  • Reducing seizures
  • Stress tolerance
  • Oxygen utilisation
  • Liver activity
  • Athletic performance
  • Anti-aging
  • Anti-inflammatory
  • Anti-viral and anti-bacterial
  • Immune boosting
  • Shrinking tumours
  • Allergies
  • Chronic fatigue syndrome
  • Respiratory disorders
  • Alcoholism, drug addiction.
  • Cholesterol and triglycerides
  • Blood pressure
  • Blood glucose

Although DMG has all of these benefits, and is available as a supplement, LeanMachine recommends that people supplement with TMG as we then receive all of the benefits of DMG plus the benefit of 50% better methylation.

Methyl groups (CH3) are essential for millions of biochemical reactions every second in the body, these are a few examples:

  • Lowering homocysteine, an amino acid, which inflames arteries when levels rise, leading to “hardening of the arteries”. Homocysteine levels are a much better indicator of cardiovascular disease than cholesterol. High homocysteine is commonly caused by insufficient methyl groups. The body gets methyl groups from TMGActive FolateActive Vitamin B-12, SAM-eDMAEMethionineTaurine, Cysteine and Vitamin B-6.
    Other causes of high homocysteine are mercury and copper toxicity. High homocysteine also causes methionine deficiency, in turn causing SAM-e (S-Adenosyl Methionine) deficiency which can lead to depression. Methionine is required for protein synthesis
  • Excess homocysteine also leads to osteoporosis, birth defects, cancer, ageing and free radicals, all helped by TMG
  • Methyl groups are required for the Phase 2, P450 liver detoxification pathway, a critical biochemical sequence of events. Fat-soluble toxins are joined to a methyl group, enabling a greater water solubility, then allowing the liver to remove them from the body. For toxins unable to be removed, methylation helps render them less toxic
  • TMG increases production of SAM-e, helping to reduce depression
  • TMG reduces risk of diabetes, as insulin release and insulin activity rely on methyl group donation
  • TMG donates methyl groups for protein synthesis (biosynthesis), the copying of genetic code from DNA to RNA (genetic transcription), then to the synthesis (formation) of every chemical in the body
  • TMG insufficiency causes biosynthesis slowing, telomeres shortening, and genetic errors (transcription errors) raises cancer risk from DNA mutations

The Methylation Process

This is a vital and most common chemical process in hundreds of essential chemical reactions, including:

  • Methylation is essential for manufacture of all the chemicals for the body
  • Stops certain viruses that could damage DNA
  • Stops the production of trophoblast (fast-growing cells that may lead to cancer)
  • Suppresses replication of DNA in areas where the body does not want it replicated
  • Important for neurological chemicals and blood chemicals
  • Corrects timing problems of the X chromosome in cell replication
  • Causea a genetic trait to come from only one parent, and not both
  • Prevents some genetic diseases
  • Helps prevent shortening of gene telomeres
  • Methylation is a primary method of removing toxins in the phase 2 liver detoxification system
  • Methylation converts toxins of all kinds from insoluble, less soluble or fat-soluble compounds into water-soluble compounds to allow excretion. Larger molecules are eliminated through the bile, smaller ones are excreted in the urine
  • Methylation is required for synthesis of dopamine and serotonin, improving mood, energy, wellbeing, alertness, concentration, and visual clarity
  • Methylation helps with liver detoxification
  • Methylation is required for conversion of homocysteine to methionine, which converts to other amino acids by various pathways
  • Methylation helps balance hormones such as estrogens, reducing risk of estrogen-related cancers
  • Reduces inflammation by removing toxins, balancing hormones, synthesising neurotransmitters and other methods
  • Methylation protects the mitochondria and adaptive energy production to stop us from becoming very tired
  • Restores SAM-e in spinal fluid, working as a methyl donor when restored by methyl groups
  • Methylation is required for the body to make CoQ10 (Coenzyme Q10), vital for heart health and energy production in the mitochondria
  • Methylation increases muscle mass, important in cancer and other wasting diseases, and for general health
  • Methylation may improve libido in some people

Who needs TMG?

Almost everyone needs supplemental TMG, even healthy people with a healthy diet, to provide enough methylation for modern life. Those subject to stress, toxins, cardiovascular disease, mental illness, depression, fatigue, exhaustion or almost any other medical condition, almost certainly need extra TMG.

Other benefits of TMG

The Parasympathetic System

TMG can improve the parasympathetic system, helping balance the autonomic nervous system. Hair mineral analyses show about half the population has an autonomic nervous system imbalance (sympathetic dominance), where the sympathetic (fight-or-flight) nervous system is “switched on” too often and too long, usually due to stress, causing many chronic health conditions. TMG may help reverse any imbalance, contributing to healing. Some doctors use “sympathetic dominance” in a different context such as “a sympathetic state of body chemistry” which is different from “sympathetic dominance” used here.

The MTHFR Defect

Almost half the people on Earth have the abnormal MTHFR gene expression, where the biosynthesis of folate is reduced, sometimes marginally, sometimes largely.
Often incorrectly called a “genetic defect” when it is actually a transcription error, polymorphism or abnormal gene expression where errors occur in copying the DNA code rather than a problem with the actual DNA code.
This is why Active Folate has benefits, as it is already in the (6S)-5-methyltetrahydrofolate form required by the body, while regular folate must be converted in the body to this form.
TMG can help supply the methyl groups where insufficent folate cannot. Active folate can be up to 700% more useful in the body, compared to regular folic acid. Note that folic acid is a cheap folate substitute used in many foods claiming to be “folate enriched” but folic acid may prevent absorption of real folate in foods or active folate supplements, and LeanMachine advises total avoidance of foods or supplements containing folic acid.

Antioxidant and anti-inflammatory

There are not many reports on these properties, but they do exist, possibly as a result of methyl group donation

Effects on the Brain

TMG has a positive effect on the brain, likely due to methylation and SAM-e production. Recommended for those at high risk for Alzheimer’s, dementia, Parkinsons, depression, anxiety, seizures, migraine headache, ADHD (Attention Deficit-Hyperactivity Disorder), MS (Multiple Sclerosis) and other brain conditions.

SAM-e Benefits

1. Heart Disease

SAM-e is used for heart disease, also for fibromyalgia, abdominal pain, osteoarthritis, bursitis, tendonitis, chronic lower back pain, ageing, CFS (Chronic Fatigue Syndrome), improving mental performance, liver disease, spinal cord injury, lead poisoning, to break down bilirubin or porphyrin (or precursors).

2. PMS

SAM-e is often taken for PMS (Premenstrual Syndrome) and a more severe form PMDD (Premenstrual Dysphoric Disorder).

IV use of SAM-e

IV (Intravenous) use of SAM-e is used for depression, osteoarthritis, AIDS-related nervous system disorders, fibromyalgia, liver disease, cirrhosis, and intrahepatic cholestasis (a liver disorder in pregnant women)

SAM-e Injections

SAM-e is often injected for fibromyalgia, depression, and Alzheimer’s disease.

Effects on Digestion

TMG aids digestion, again likely because of positive methylation throughout the body.

Glycine

Glycine is the component left over when all three methyl groups have been donated from TMG.
Glycine is the smallest of the amino acids and very important for collagen formation and many other functions. Collagen, the most abundant protein in the body, is used for connective tissue: Tendons, ligaments, cartilage, skin, nails, arteries, veins, etc. Without collagen, we could not stand up, our body would be a pile of mush on the floor!
Glycine, in large doses (up to 3000 mg daily), has been found helpful for sleep and alertness. Although not recommended as a first-line supplement for sleep, it may help if other supplements like Valerian fail to work. This may explain why TMG helps induce restful sleep in some individuals.

Natural sources of TMG

TMG is normally made in the body, but not enough when there are toxins present or the diet is poor or absorption of nutrients is a problem.
TMG can come from the diet. Foods high in TMG include broccoli, quinoa, spinach, lamb, chicken, and beets. A vegetarian or vegan diet tends to be very low in TMG. Foods high in TMG are usually also high in folate, and both are methyl donors.
However, most people do not eat enough of these foods, and even eating large amounts will not provide enough TMG for optimum health.

Risk factors for low TMG

Generally, the body cannot make enough, the modern diet is poor in TMG, and the number of pesticides, chemicals, heavy metal contamination uses up all TMG available.

  • Mercury is a poison that lowers TMG production in the body, and at the same time increases the need for TMG in the body. Almost everyone is mercury toxic now, as mercury is everywhere in the environment, especially in seafood and in dental amalgam fillings
  • Copper toxicity also interferes with TMG, and most people today are toxic from copper pipes, tapware, cookware even if blood or urine tests are negative. While copper is essential for the body to build hemoglobin in blood, we need Chelated Copper from food or supplements, not metallic copper from copper pipes and cookware. Zinc deficiencies cause accumulation of copper in the body, and women have a higher risk than men. Causes headaches, female organ problems, depression, anxiety, skin conditions. Too much zinc (and/or magnesium) competes with copper for absorption, often leading to a copper deficiency.

Supplements

Supplementary TMG is helpful for most people because of low body production, low in the diet, and higher requirements in our toxic world.
TMG 1000mg 100 tablets (most popular, best value).

Stress

Stress, inflammation, inflammation and some diseases increase our need for more TMG.

Dosage of TMG

  • Women: Up to 1000 mg daily
  • Men: Up to 3000 mg daily
  • Children: Less than adults, in proportion to body weight

There are no reliable guides or tests to determine TMG dosage, but the figures above should be a good starting point.
If the sodium/potassium ratio is low, extra TMG may help.
Do not overdose, as too much TMG may lead to over-methylation, causing fatigue, nausea, hair loss, dizziness or other symptoms.
Most people have no side effects from TMG apart from feeling better, getting better sleep and having more energy.
Cautions:
Do not continue a high dose for extended periods.
Children need proportionately less TMG than adults, depending on their size and weight, but babies generally do not need TMG. Older children may need about 250 to 500 mg daily.
TMG is available as tablets, liquid capsules or crystals. Some children and the elderly may have problems with swallowing tablets. TMG has a sweet taste, so TMG crystals can be simply added to food.
Some people have problems tolerating TMG, so they may need a smaller dose. Try reducing the dose until any symptoms disappear.
People who have unresolved resentments seem to have more problems taking TMG, as an enzyme is activated which can cause anger, fear, depression or anxiety symptoms. These symptoms disappear if the dose is reduced or eliminated, but if one can tolerate the symptoms, TMG may help the person resolve their issues of conflict.
Some reports suggest that too much TMG may cause diarrhea and nausea, and may raise cholesterol levels, so those with high cholesterol should keep the level monitored.

Poor Methylation

Several factors affect poor methylation, such as:

  • Raw vegetables are considered healthy, but cooked vegetables provide more dietary methyl groups
  • Sugars in any form appear to harm correct methylation, and are bad for our health anyway
  • Fermented foods are healthy, but are problem for methylation because:
    • Some contain aldehydes (toxic to the liver), including kombucha tea, kimchi, and most fermented grains
    • They contain ferments, which are bacteria or yeasts

    Safer fermented foods, eaten in moderation, include yogurt, kefir, miso and most good quality cheeses

  • Too much animal protein in the diet can cause high methionine and reduce methylation
  • Fighting inflammation or infections consumes methyl groups, requiring more methylation
  • Heavy metal toxicity, especially copper and mercury, interfere with methyl group formation
  • High-dose niacin or niacinamide cause the body to use up methyl groups to detoxify and excrete niacin through the liver. Doses less than 50 mg daily are generally tolerated well
  • Any liver toxins will reduce formation of methyl donors, also liver detoxification pathways require methyl groups, using up more methyl groups
  • Methyl donor production seems to decrease with age, so seniors need more TMG
  • Women of child-bearing age have much better methylation than men. Men always need more TMG than women

Methylation and Cancer

Cancer increases the need for methylating agents like TMG. People often die with cancer because they cannot eliminate their toxic metals and chemicals because of poor liver methylation, so toxins accumulate until death occurs.

Hair Mineral Analysis

More TMG may be required if a hair mineral test reveals:

  • High zinc level, which may indicate presence of hidden toxic metals
  • “Four lows pattern” meaning all four electrolyte minerals low: Calcium, Magnesium, Sodium, Potassium. Indicates impaired methylation
  • High mercury, becoming more common
  • High copper
  • High levels of the other toxic metals

These results indicate long-term toxic metal exposure.

Disclaimer

LeanMachine is not a doctor, and everyone should consult with their own health professional before taking any product to ensure there is no conflict with existing prescription medication.
LeanMachine has been researching nutrition and health since 2010 and has completed many relevant studies including:
Open2Study, Australia – Food, Nutrition and Your Health
RMIT University, Australia – Foundations of Psychology
Swinburne University of Technology, Australia – Chemistry – Building Blocks of the World
University of Washington, USA – Energy, Diet and Weight
Johns Hopkins Bloomberg School of Public Health, USA – Health Issues for Aging Populations
Johns Hopkins Bloomberg School of Public Health, USA – International Nutrition
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics I
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics II
Johns Hopkins Bloomberg School of Public Health, USA – Principles of Human Nutrition
TUFTS University, USA – Nutrition and Medicine
TUFTS University, USA – Lipids/Cardiovascular Disease I and Lipids/Cardiovascular Disease II
Technical Learning College, USA – Western Herbology, Identification, Formulas
Bath University, England – Inside Cancer
WebMD Education – The Link Between Stroke and Atrial Fibrillation
WebMD Education – High Potassium: Causes and Reasons to Treat
Leiden University Medical Center, Netherlands – Anatomy of the Abdomen and Pelvis
MIT (Massachusetts Institute of Technology) – A Clinical Approach to the Human Brain
LeanMachine has now examined thousands of studies, journals and reports related to health and nutrition and this research is ongoing.

Updated 16th June 2020, Copyright © 1999-2020 Brenton Wight and BJ & HJ Wight trading as Lean Machine abn 55293601287

Glutathione and NAC Play Crucial Roles in Health and Fitness


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2019/12/30/glutathione-nac-for-health-and-fitness.aspx

Analysis by Dr. Joseph Mercola Fact Checked
December 30, 2019

glutathione nac for health and fitness

STORY AT-A-GLANCE

  • Sulfur is the third most abundant mineral in your body. Sulfur-containing amino acids increase your levels of glutathione and N-acetylcysteine (NAC), which play important roles in health and fitness
  • Glutathione metabolism influences the control of epigenetic mechanisms at several levels, including substrate availability, enzymatic activity for DNA methylation and the expression of microRNAs
  • NAC supplementation may be useful for the prevention of cardiovascular problems in older people by lowering oxidative stress and improving mitochondrial function
  • Glutathione deficiency can induce epigenetic changes in genes that regulate vitamin D metabolism in the liver, and research suggests glutathione supplementation could help reduce the risk of vitamin D deficiency in obese individuals
  • Glutathione and NAC also ameliorate exercise-induced stress and reduce muscle fatigue. Glutathione may also play a central role in chronic fatigue syndrome

As explained in “The Health Benefits of MSM,” sulfur is the third most abundant mineral in your body and plays important roles in a variety of bodily processes, including metabolism and detoxification, and for maintaining the proper shape and structure of proteins and enzymes.

Sulfur-containing amino acids increase your levels of glutathione and N-acetylcysteine (NAC), and these two play important roles in health and fitness.

Glutathione Basics

Glutathione comprises three amino acids: cysteine, glutamate and glycine. It’s commonly referred to as “the master antioxidant,” as it is your body’s most powerful antioxidant, and is found inside every cell in your body.

Antioxidants combat free radicals — highly reactive particles that bounce around the cell, damaging everything they touch. Most originate during the process of metabolism but they can also arise during exercise, and from exposure to toxins, irradiation and toxic metals.

Because free radicals are so destructive, cells have a network of defenses designed to neutralize them. This antioxidant network is composed of numerous components that include vitamins, minerals and special chemicals called thiols (glutathione and alpha-lipoic acid).

Glutathione differs from other antioxidants in that it is intracellular, and has the unique ability of maximizing the activity of all the other antioxidants, including (but not limited to) vitamins C and E, CoQ10 and alpha lipoic acid. It also removes toxins from your cells and protects you from the damaging effects of radiation, chemicals and environmental pollutants.

NAC Basics

NAC is a precursor to and rate-limiting nutrient for the formation of glutathione.1 Glutathione is poorly absorbed so, in many cases, it’s easier to raise your glutathione by taking NAC instead.

In emergency medicine, NAC is used as an antidote for acetaminophen toxicity resulting from an overdose.2 Mortality due to acetaminophen toxicity has been shown to be virtually eliminated when NAC is promptly administered.

It is believed the liver damage acetaminophen causes is largely due to the fact that it can deplete glutathione, which is secreted by your liver in response to toxic exposure.

On a side note, NAC supplementation can also help “pre-tox” your body when taken before alcohol, thereby minimizing the damage associated with alcohol consumption — a tidbit that may be useful to know in light of approaching New Year’s celebrations.

Taking NAC (at least 200 milligrams) 30 minutes before you drink can help lessen the alcohol’s toxic effects. Vitamin B6 may also help to lessen hangover symptoms.

While the most common use of NAC is for liver support, it’s also showing promise as a neuroprotectant.3 Scientists are currently investigating it as a treatment for Parkinson’s disease, which has been linked to glutathione deficiency in the substantia nigra, a region that houses dopamine neurons.4

Research looking at autopsied brains suggests Parkinson’s patients have barely detectable levels of glutathione in this brain region. Subsequent studies have found glutathione deficiency in the substantia nigra is common in a number of other neurodegenerative conditions as well, including Alzheimer’s disease.5

Another area where NAC shows particular promise is in the treatment of mental health disorders, including post-traumatic stress disorder,6 depression7 and substance use disorders.8 Dozens of additional health benefits are also reviewed in a November 29, 2019, SelfHacked article.9

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Glutathione Helps Regulate Epigenetic Disease Mechanisms

One factor that can help explain the wide-ranging benefits of NAC and glutathione is glutathione’s role in the regulation of epigenetic disease mechanisms.10 As noted in a November 2017 paper in Free Radical Biology and Medicine:11

“Epigenetics is a rapidly growing field that studies gene expression modifications not involving changes in the DNA sequence.

Histone H3, one of the basic proteins in the nucleosomes that make up chromatin, is S-glutathionylated in mammalian cells and tissues, making Gamma-L-glutamyl-L-cysteinylglycine, glutathione (GSH), a physiological antioxidant and second messenger in cells, a new post-translational modifier of the histone code that alters the structure of the nucleosome.

However, the role of GSH in the epigenetic mechanisms likely goes beyond a mere structural function. Evidence supports the hypothesis that there is a link between GSH metabolism and the control of epigenetic mechanisms at different levels (i.e., substrate availability, enzymatic activity for DNA methylation, changes in the expression of microRNAs, and participation in the histone code).”

The following graphic12 illustrates how glutathione influences pathological changes in gene expression.

glutathione influences pathological changes in gene expression

NAC Improves Cardiovascular and Mitochondrial Function

According to a 2018 study,13 NAC supplementation may be useful for the prevention of cardiovascular problems in older people. As you might expect, oxidative stress can over time induce metabolic and functional changes that speed cardiovascular aging and dysfunction, and your glutathione levels declines with age, putting you at greater risk.

In this study, aging mice received either NAC or a combination of NAC and glycine. After seven weeks, their cardiac function was assessed, showing those receiving NAC plus glycine had improved several parameters of their cardiovascular function, including:

  • Improved diastolic function
  • Increased peak early filling velocity
  • Reduced relaxation time
  • Reduced left atrial volume
  • Reduced left ventricle end diastolic pressure

NAC alone did not impart these cardiovascular benefits, although both groups had decreased levels of inflammatory mediators. The NAC and glycine combination also improved mitochondrial function and upregulated mitochondrial genes in the heart that are normally downregulated with age.

According to the authors, “Our data indicate that NAC+Gly supplementation can improve diastolic function in the old mouse and may have potential to prevent important morbidities for older people.”

Glutathione Deficiency Lowers Vitamin D Levels in the Obese

Other recent research14 published in Scientific Reports shows that glutathione deficiency can induce epigenetic changes in genes that regulate vitamin D metabolism in the liver. Emerging evidence also suggests glutathione metabolism plays a role in the epigenetic regulation of oxidation-reduction (redox) reactions, the authors note.

According to this paper,15 obesity has been correlated with low levels of glutathione and 25-hydroxyvitamin D3 — especially in Type 2 diabetics and the obese16 — and when obese mice were fed a glutathione-deficient diet, it downregulated vitamin D metabolism genes and vitamin D receptors in the liver. As a result, oxidative stress increased.

According to the authors, their findings suggest glutathione supplementation could help reduce the risk of vitamin D deficiency in obese individuals. Supplementation with L-cysteine, a rate-limiting precursor to glutathione, has also been shown to increase vitamin D levels and reduce oxidative stress, the paper notes, which supports the link between glutathione and vitamin D.

Glutathione and NAC Ameliorate Exercise-Induced Stress

As mentioned earlier, exercise is one of the ways through which free radical production increases and, with it, oxidative stress. Provided you get enough rest between bouts, this oxidative stress is actually part of what makes exercise so beneficial.

That said, as noted in a 2005 paper,17 “Effective regulation of the cellular balance between oxidation and antioxidation is important when considering cellular function and DNA integrity as well as the signal transduction of gene expression.” In other words, excessive exercise can cause more harm than good. As explained by the authors:18

Exercise enthusiasts and researchers have become interested in recent years to identify any means to help minimize the detrimental effects of oxidative stress that are commonly associated with intense and unaccustomed exercise. It is possible that a decrease in the amount of oxidative stress a cell is exposed to could increase health and performance …

To protect against the deleterious effects of ROS [reactive oxygen species], our bodies have a complex system of endogenous antioxidant protection in the form of enzymes such as superoxide dismutase, catalase, and glutathione peroxidase. Under normal, resting conditions reactive oxygen species are removed from the cell preventing any subsequent damage.

However, under more extreme conditions such as: 1) inadequate intake of foodstuffs containing the antioxidants, 2) excessive intake of pro-oxidants, 3) exposure to noxious chemicals or ultraviolet light, 4) injury/wounds, and/or 5) intense exercise, especially eccentric exercise, the body’s endogenous antioxidant system is not able to effectively remove excessive ROS production.

In situations such as the ones listed above in which the production of pro-oxidant molecules increase to a point where the antioxidant system cannot effectively remove them is when oxidative stress is known to occur.

Oxidative stress has been implicated in a number of diseases which include atherosclerosis, pulmonary fibrosis, cancer, Parkinson’s disease, multiple sclerosis, and aging. Research on oxidative stress during exercise has begun to indicate that regular training enhances the ability of these mechanisms to effective respond to the increase of oxidative product.”

Exercise Boosts Your Glutathione Level

The 2005 paper above goes on to explain how exercise affects your glutathione level, and thus your health, fitness and risk of disease. In short, when you engage in intense exercise, your blood level of glutathione significantly decreases while circulating levels of oxidized glutathione increases, indicating that it’s been used inside the muscle to quench free radicals produced during the exertion.19

Considering the importance of glutathione to counteract free radicals, effective regulation of glutathione levels when exercising is a significant concern. The good news is that the more you exercise, the higher your base levels of glutathione get.

This adaptation allows your body to effectively deal with the increase in free radicals that the exercise brings about. While exercise itself will boost your glutathione level over time, raising glutathione through supplementation is an oft-used strategy among athletes.

As mentioned, glutathione supplementation is ineffective due to its poor absorption, so NAC is generally considered a much better choice. According to the authors of the 2005 paper cited above:20

“In addition to the role glutathione and other thiols have on maintaining the cellular redox state, many studies have begun to explore if NAC supplementation can actually improve performance due to its ability to promote a more favorable cellular environment to achieve higher levels of performance …

One of the first studies to utilize NAC to determine its role in improving muscle performance was conducted by Reid and colleagues. They pretreated subjects with n-acetyl-cysteine infusion (150 mg/kg) or a 5% dextrose placebo while undergoing an extended fatiguing bout of electrical stimulation of the ankle dorsiflexors.

N-acetyl-cysteine was found to have no impact over the nonfatigued muscle, but a significantly increased force output of approximately 15% was found after 3 minutes of repetitive contractions which persisted throughout the 30-minute protocol. The authors concluded that NAC resulted in improved performance suggestive of oxidative stress having a causal role in the fatigue process.”

Other studies have also confirmed that NAC supplementation helps delay muscle fatigue during exercise, thereby improving endurance. In one study,21 NAC infusion increased the time to exhaustion by 26.3%.

NAC’s ability to reduce fatigue and improve cellular redox (oxidation reduction) also hints at its potential benefit for those struggling with chronic fatigue syndrome (CFS).

The Glutathione Depletion Theory of CFS

As explained by the U.S. Centers for Disease Control and Prevention, CFS, also known as myalgic encephalomyelitis or ME, is characterized by “overwhelming fatigue that is not improved by rest.”22 The fatigue is frequently such that it challenges your ability to perform even the most common of daily life tasks, such as showering or preparing a meal.

The role of glutathione in this condition is addressed in “A Simple Explanation of the Glutathione/Methylation Depletion Theory of ME/CFS”23 by the late Rich Van Konynenburg, Ph.D., developer of the methylation protocol used by many in the CFS community.24,25

According to Van Konynenburg, oxidative stress “is probably the best-proven biochemical aspect of chronic fatigue syndrome,” and in order for your oxidative stress to overwhelm your system, something must be placing excessive demands on your glutathione supply.

Several examples were already listed above, such as inadequate antioxidant and/or excessive pro-oxidant intake, toxic exposures and physical injuries. Long-term emotional stress can also be a factor. As noted in Van Konynenburg’s article:

“All people experience a variety of stressors all the time, and a healthy person’s body is able to keep up with the demands for glutathione by recycling used glutathione molecules and by making new ones as needed.

However, if a person’s body cannot keep up, either because of extra-high demands or inherited genetic polymorphisms that interfere with recycling or making glutathione, or both, the levels of glutathione in the cells can go too low …

One of the jobs that glutathione normally does is to protect your supply of vitamin B12 from reacting with toxins … When your glutathione level goes too low, your B12 becomes naked and vulnerable, and is hijacked by toxins.

Also, the levels of toxins rise in the body when there isn’t enough glutathione to take them out, so there are two unfortunate things that work together to sabotage your B12 when glutathione goes too low.”

The B12-Glutathione Connection

Vitamin B12 helps your body convert food into glucose for energy, and fatigue is one of the symptoms of low B12 levels.26 Interestingly, many with CFS have elevated B12 levels. Their bodies simply cannot use it properly, and one potential culprit is low glutathione.

“The best test to reveal this is a urine organic acids test that includes methylmalonic acid. It will be high if the B12 is being sidetracked, and this is commonly seen in people with CFS,” Van Konynenburg states, adding:27

“The most important job that B12 has in the body is to form methylcobalamin, which is one of the two active forms of B12. This form is needed by the enzyme methionine synthase, to do its job. An enzyme is a substance that catalyzes, or encourages, a certain biochemical reaction.

When there isn’t enough methylcobalamin, methionine synthase has to slow down its reaction. Its reaction lies at the junction of the methylation cycle and the folate cycle, so when this reaction slows down, it affects both these cycles …

The methylation cycle has some important jobs to do. First, it acts as a little factory to supply methyl (CH3) groups to a large number of reactions in the body. Some of these reactions make things like creatine, carnitine, coenzyme Q10, phosphatidylcholine, melatonin, and lots of other important substances for the body.

It is not a coincidence that these substances are found to be low in CFS … Not enough of them is being made because of the partial block in the methylation cycle.

The methylation cycle also supplies methyl groups to be attached to DNA molecules, and this helps to determine whether the blueprints in the DNA will be used to make certain proteins according to their patterns.

The ‘reading’ of DNA is referred to as ‘gene expression.’ Methyl groups prevent or ‘silence’ gene expression. Overexpression of genes has been observed in CFS patients, and I suspect this is at least partly due to lack of sufficient methylation to silence gene expression.”

The Basic Biochemical Mechanism of CFS

The methylation cycle also regulates your body’s use of sulfur, and the production of sulfur-containing substances, including glutathione. CFS patients often have abnormal levels of sulfur metabolites. Once you understand the interconnectedness of glutathione, B12 and the methylation cycle, it becomes easier to see how chronic CFS arises. As explained by Van Konynenburg:28

“When glutathione goes too low, the effect on vitamin B12 slows down the methylation cycle too much. The sulfur metabolites are then dumped into the transsulfuration pathway (which is connected to the methylation cycle) too much, are oxidized to form cystine, pass through hydrogen sulfide, and are eventually converted to thiosulfate and sulfate and are excreted in the urine.

This lowers the production of glutathione, which requires cysteine rather than cystine, and now there is a vicious circle mechanism that preserves this malfunction and keeps you sick … That’s the basic biochemical mechanism of CFS … everything else flows from this …

Here’s how I believe the fatigue occurs: The cells have little powerplants in them, called mitochondria. Their job is to use food as fuel to produce ATP (adenosine triphosphate). ATP acts as a source of energy to drive a very large number of reactions in the cells.

For examples, it drives the contraction of the muscle fibers, and it provides the energy to send nerve impulses. It also supplies the energy to make stomach acid and digestive enzymes to digest our food, and many, many other things.

When glutathione goes too low in the muscle cells, the levels of oxidizing free radicals rise, and these react with parts of the ‘machinery’ in the little powerplants, lowering their output of ATP.

So the muscle cells then experience an energy crisis, and that’s what causes the fatigue. Over time, because of the lack of enough glutathione, more problems accumulate in the mitochondria, including toxins, viral DNA, and mineral imbalances.”

All of these factors will ultimately decimate your immune function as well, allowing pathogenic bacteria, viruses and fungi to take over. CFS patients will frequently have several infections ongoing at the same time. Low glutathione also impedes your body’s natural detoxification pathways, allowing toxicity to build over time, thereby causing ever-increasing dysfunction.

The Answer for CFS

So, how do you turn this chain of events around? As noted in Van Konynenburg’s article:29

“The main key to turning this process around is to help the methionine synthase enzyme to operate more normally, so that the partial block in the methylation cycle and the folate cycle are lifted, and glutathione is brought back up to normal. That is what the simplified treatment approach is designed to do, and so far, the evidence is that it does do these things in most people who have CFS.

I recommend that people with CFS have the Vitamin Diagnostics methylation pathways panel run to find out if they do in fact have a partial methylation cycle block and glutathione depletion before deciding, with their doctors, whether to try this treatment.

This also provides a baseline so that progress can be judged later on by repeating it every few months during the treatment. Symptoms may not be a good guide to judge progress during treatment, because detoxing and die-off can make the symptoms worse, while in fact they are exactly what is needed to move the person toward recovery.”

An outline of Van Konynenburg’s simplified methylation treatment plan for CFS can be found in HealthRising.org.30 At the core of this treatment is the use of specific supplements, including folate, B12, a multivitamin, SAMe and phosphatidyl serine.

In his protocol, he explains the theory behind the use of each of these supplements, how they impact the methylation cycle, and their interactions with other supplements.

My take-home message here is that glutathione and NAC supplementation may not always be the ideal way to go. People with CFS may be better supported by a customized assessment by an experienced clinician that may also include methyl folate and methyl vitamin B12.

General Dosing and Safety Guidelines for NAC

For many others, however, NAC can be safely used to boost glutathione levels. For more information about how NAC can benefit your health, see “The Many Benefits of NAC.” It’s widely available as an oral dietary supplement and is relatively inexpensive. Unfortunately, like glutathione, NAC is poorly absorbed when taken orally, although it’s better than glutathione.

According to some studies,31,32 NAC’s oral bioavailability may range between 4% and 10%, which is why the recommended dosage can go as high as 1,800 milligrams (mg) per day. Its half-life is also in the neighborhood of two hours, which is why most study subjects take it two or three times a day.

No maximum safe dose has yet been determined, but as a general rule, it’s well-tolerated, although some do experience gastrointestinal side effects such as nausea, diarrhea or constipation. Should this occur, reduce your dosage. It’s also best taken in combination with food, to reduce the likelihood of gastrointestinal effects.

Also keep in mind that since NAC boosts glutathione, which is a powerful detox agent, you may experience debilitating detox symptoms if you start with too high a dose. To avoid this, start low, with say 400 to 600 mg once a day, and work your way up.

Also, if you are currently taking an antidepressant or undergoing cancer treatment, be sure to discuss the use of NAC with your physician, as it may interact with some antidepressants and chemotherapy.

 Sources and References

The cancer fighting benefits of Coenzyme Q10

Reproduced from original article:
www.naturalhealth365.com/benefits-of-coq10-3221.html

by:  

benefits-of-coq10

(NaturalHealth365) Coenzyme Q10, or CoQ10, is a substance found in every cell of our body. It is in a variety of foods, and healthy people are not likely to develop a deficiency of this nutrient. But, you might want to think about taking in some extra CoQ10 – especially if you’re taking a statin to lower your cholesterol levels.

CoQ10 has many potential health benefits, including possibly lowering the risk of certain cancers. Women, especially, should take note, since recent research points to links between breast cancer risk and lower levels of CoQ10 in the blood.

Clearing up the confusion about CoQ10

Coenzyme Q10 is technically not a vitamin because your body can synthesize it, so you do not need to get it from food. However, its structure is similar to that of vitamins. Also like vitamins, it acts as a coenzyme functions in your body’s metabolic reactions.

CoQ10 also has powerful antioxidant properties. For example, it helps prevent harmful oxidation of LDL cholesterol, and it supplements the work of vitamin E, or tocopherol. When your blood levels of CoQ10 are lower, your body needs more vitamin E from the diet to carry out heart-healthy antioxidant reactions.

What are the health benefits associated with CoQ10?

Can a Coenzyme Q10 deficiency increase the risk of cancer?

Since the 1960s, researchers have noted associations between lower blood levels of CoQ10 and cancer. People with lymphoma, myeloma, and lung, head, neck, and prostate cancers tend to have lower levels of CoQ10.

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A recent study looking into links between CoQ10 and breast cancer examined data from nearly 1,000 women aged 40 to 70 in the Shanghai Women’s Health Study. Those who had serum levels of CoQ10 in the bottom fifth of participants had a 90 percent greater chance of being diagnosed with breast cancer than those whose levels were in the middle fifth.

“The current Shanghai Women’s Health Study, with relatively larger sample size and longer follow-up time suggests an inverse association for plasma CoQ10 levels with breast cancer risk in Chinese women,” according to study authors Robert V. Cooney of the University of Hawaii and colleagues. Based on these results, future research should investigate potential effects of supplementation on the risk of breast cancer.

The study also confirmed the association between low CoQ10 and higher risk of cervical cancer, myeloma, and melanoma. This makes the results relevant to men as well as women. This study is far from definitive, but it seems likely that there is a link between healthy CoQ10 levels and reduction in cancer risk.

CoQ10 is in a variety of foods, including meat, fish, and eggs, and organ meats, such as heart, kidney, and liver, are especially rich sources. You can also find CoQ10 in plant-based foods, such as cauliflower, peanuts, soybean oil, and strawberries.

Obviously, you can obtain additional benefits, with ease, by supplementing your diet with a high quality CoQ10 supplement.

Sources for this article include:

Healthline.com
NaturalHealth365.com

Better Than Zoloft for Depression: Rhodiola

© 30th October 2019 GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here www.greenmedinfo.com/greenmed/newsletter
Reproduced from original article:
https://www.greenmedinfo.health/blog/better-zoloft-depression-rhodiola

Posted on: Wednesday, October 30th 2019 at 5:00 pm

Will doctors ever opt for an herb over a drug for depressed patients? It may sound unlikely but researchers from the University of Pennsylvania think they should consider it

In a randomized placebo-controlled trial doctors tested the herb rhodiola rosea against the conventional antidepressant therapy sertraline (Zoloft) in patients with major depressive disorder (MDD).[i]

A diagnosis of MDD means a patient exhibited two or more major depressive episodes, depressed mood and/or loss of interest or pleasure in life activities for at least 2 weeks. In addition, they show signs of significant unintentional weight loss or gain, insomnia or sleeping too much, fatigue, diminished ability to think or concentrate, and recurrent thoughts of death.

The study looked at 57 adults diagnosed with major depressive disorder. The patients received treatments of either rhodiola rosea extract, sertraline, or placebo.

After 12 weeks there was no statistically significant difference between the rhodiola and the Zoloft. Compared to the placebo, rhodiola patients had 1.4 times the odds of improvement while the Zoloft patients had 1.9 times the odds of improvement.

Other evidence is mounting that Zoloft and other SSRIs are no more effective than placebo for depression symptoms.

In the Penn study the researchers concluded that rhodiola may possess a more favorable risk to benefit ratio for individuals with mild to moderate MDD because it produced only half the side effects of Zoloft. In fact, a whopping 63% of patients on Zoloft reported side effects – most commonly nausea and sexual dysfunction. That compared to only 30% of patients on rhodiola.

The authors suggested that “herbal therapy may have the potential to help patients with depression who cannot tolerate conventional antidepressants due to side effects.”

An earlier placebo controlled study found rhodiola effective for patients with mild to moderate depression.

Rhodiola rosea is a hardy yellow flower native to the arctic mountains of Eastern Siberia. It’s sometimes called the “Root of the Arctic” or Tibetan ginseng.

Ancient healers used rhodiola to treat infections, anemia, stomach upset, and depression. In the old Soviet Union scientists used rhodiola to help soldiers improve mood, brain function and physical performance.

Human studies show that just one 200 mg dose of rhodiola helped volunteers improve their exercise endurance.[ii]

It’s also been shown to relieve mental fatigue. In one study of doctors on night call just 170 mg of rhodiola per day for two weeks helped the doctors think and remember better, concentrate, calculate, and respond to audio and visual cues.[iii]

And taking 100 mg of rhodiola every day for 20 days helped students improve their capacity to work, their coordination, and their general sense of wellbeing. Their learning ability increased 61% and their fatigue levels dropped by 30%.[iv]

Another study showed rhodiola may be helpful in smoking cessation.

For more information visit GreenMedInfo’s page on rhodiola/Tibetan ginseng. For an extensive list of natural anti-depressive agents take a look at GreenMedInfo.com’s depression page. Or, read a summary article titled, 23 Natural Alternatives for Depression.

Originally published: 2015-06-08

Article updated: 2019-10-30


References

[i] Jay D. Amsterdam et al. “Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial.” Phytomedicine, 2015 Mar 15;22(3):394-9. doi: 10.1016/j.phymed.2015.01.010. Epub 2015 Feb 23.

[ii] De Bock K, Eijnde BO, Ramaekers M, Hespel P. “Acute Rhodiola rosea intake can improve endurance exercise performance.” Int J Sport Nutr Exerc Metab. 2004 Jun;14(3):298-307.

[iii] Darbinyan V, Kteyan A, Panossian A, et al. “Rhodiola rosea in stress induced fatigue—a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty.” Phytomedicine. 2000 Oct;7(5):365-71.

[iv] Spasov AA et al. “A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen.” Phytomedicine. 2000 Apr;7(2):85-9.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

LeanMachine Notes:

I have been recommending Rhodiola for years to my patients, with a high degree of success.
This Solgar brand is high quality, coming in a darkened glass container for purity and freshness.
I am told the American Astronauts were sick after landing from prolonged space missions, while their Russian counterparts were out playing tennis, their recovery attributed to Rhodiola.

Trans Fats Linked to Increased Risk for Alzheimer’s


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2019/11/07/trans-fats-and-alzheimers.aspx

Analysis by Dr. Joseph MercolaFact Checked

STORY AT-A-GLANCE

  • Three dietary components shown to promote dementia and Alzheimer’s disease are sugar (especially processed fructose), grains and trans fats
  • Research published in the October 2019 issue of Neurology found a strong link between trans fat consumption and incidence of dementia and its various subtypes, including Alzheimer’s disease
  • People in the highest quartile of trans fat levels were 74% more likely to develop dementia. Those in the second-highest quartile had a 52% higher risk
  • Diets rich in carbohydrates are associated with an 89% increased risk for dementia while diets high in healthy fats are associated with a 44% reduced risk
  • Up to half of all Alzheimer’s cases could also be prevented by addressing other modifiable lifestyle contributors such as physical inactivity, depression, smoking, high blood pressure, midlife obesity and diabetes

As noted by neurologist Dr. David Perlmutter, author of “Grain Brain” and “Brain Maker,” your diet and other lifestyle factors have major implications for your Alzheimer’s risk.

Indeed, according to research1,2 published in the journal Lancet Neurology in 2011, up to half of all Alzheimer’s cases could be prevented by addressing modifiable lifestyle contributors such as physical inactivity, depressionsmokinghigh blood pressure, midlife obesity and diabetes.

Three dietary components shown to promote this neurological degeneration are sugar (especially processed fructose), grains and trans fats. Research3,4 from the Mayo Clinic, published in the Journal of Alzheimer’s Disease in 2012, found diets rich in carbohydrates are associated with an 89% increased risk for dementia while diets high in healthy fats are associated with a 44% reduced risk.

As noted by the authors,5 “A dietary pattern with relatively high caloric intake from carbohydrates and low caloric intake from fat and proteins may increase the risk of MCI [mild cognitive impairment] or dementia in elderly persons.” Similarly, a 2013 study6 in the journal BioMed Research International reported that:

“Increasing epidemiological studies suggest that diet and nutrition might be important modifiable risk factors for AD [Alzheimer’s disease].

Dietary supplementation of antioxidants, B vitamins, polyphenols, and polyunsaturated fatty acids are beneficial to AD, and consumptions of fish, fruits, vegetables, coffee, and light-to-moderate alcohol reduce the risk of AD … Adherence to a healthy diet, the Japanese diet, and the Mediterranean diet is associated with a lower risk of AD.”

Trans Fat Consumption Increases Your Dementia Risk

Most recently, research7 published in the October 2019 issue of Neurology found a strong link between trans fat consumption and incidence of dementia and its various subtypes, which includes Alzheimer’s disease (AD).

The study included 1,628 Japanese seniors aged 60 and older. None had dementia at the outset of the study, which went on for 10 years. Levels of elaidic acid — a biomarker for industrial trans fat — in the participants’ blood were measured using gas chromatography/mass spectrometry.

Based on those levels, the hazard ratios for all-cause dementia, AD and vascular dementia were calculated using the Cox proportional hazards model. As reported by the authors:8

“Higher serum elaidic acid levels were significantly associated with greater risk of developing all-cause dementia and AD after adjustment for traditional risk factors. These associations remained significant after adjustment for dietary factors, including total energy intake and intakes of saturated and polyunsaturated fatty acids.”

This increase in risk was not slight. As reported by CNN,9 people in the highest quartile of elaidic acid levels were 74% more likely to develop dementia. Those in the second-highest quartile had a 52% higher risk. No association between trans fat and vascular dementia was found.

Of the various processed foods found to contribute to elevated elaidic acid levels, pastries were the biggest contributors, followed by margarine, candy, caramels, croissants, nondairy creamers, ice cream and rice cakes.10

Dr. Richard Isaacson, a neurologist and director of the Alzheimer’s Prevention Clinic at Weill Cornell Medicine in New York, who was not involved in the study, commented on the findings to CNN:11

“The study used blood marker levels of trans fats, rather than more traditionally used dietary questionnaires, which increases the scientific validity of the results. This study is important as it builds upon prior evidence that dietary intake of trans fats can increase risk of Alzheimer’s dementia.”

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What Is Trans Fat?

As explained by CNN:12

“… artificial trans fats are created by an industrialized process that adds hydrogen to liquid vegetable oils to make them more solid (think of semi-soft margarine and shortening).

The food industry loves trans fats because they are cheap to produce, last a long time and give foods a great taste and texture. Besides fried foods, trans fats are found in coffee creamer, cakes, pie crusts, frozen pizza, cookies, crackers, biscuits and dozens of other processed foods.”

Trans fats are different from an unsaturated fat by a single hydrogen molecule on the opposite side of a carbon bond.13 This one positional change is responsible for the difference in characteristics of the fat, and the increased danger to your health.

Aside from dementia, strong evidence also links trans fats with inflammation and the development of insulin resistance and heart disease (all of which also happen to be risk factors for Alzheimer’s).

Faced with overwhelming evidence of harm, the U.S. Food and Drug Administration removed partially hydrogenated oils (a primary source of trans fat) from the list of “generally recognized as safe” (GRAS) list of food ingredients in 2015, and as of June 18, 2019, food manufacturers are no longer allowed to use partially hydrogenated oils in foods14 due to their health risks.

Processed foods manufactured before this date, however, are allowed to remain on the market until January 1, 2021.15 (Compliance dates vary depending on whether manufacturers had “limited use” permissions for partially hydrogenated oils, but these are the final dates where all use must cease.)

However, that doesn’t mean that trans fats have been entirely eliminated and are of no further concern. What’s more, as long as a food contains less than 0.5 grams of trans fat per serving, food manufacturers are allowed to label it as trans fat free.

The problem with this is that many experts agree there is no safe threshold below which trans fats are safe.16 To determine whether a product might still contain trans fats, carefully read the ingredients list.

Any item containing partially hydrogenated vegetable oil is bound to contain trans fat, even if the label says “0 Trans Fat.” Fried food and baked goods in general are also suspect.17,18 As lead study author Dr. Toshiharu Ninomiya, a professor at Kyushu University in Fukuoka, Japan, noted in a press release:19

“In the United States, the small amounts still allowed in foods can really add up if people eat multiple servings of these foods, and trans fats are still allowed in many other countries.”

Trans Fat Has Killed Millions

The rise of trans fat can be directly attributed to the wrongful vilification of saturated fats and cholesterol. We now have decades’ worth of data showing saturated fat and dietary cholesterol have no impact on heart disease and mortality. Meanwhile, studies have revealed the switch from saturated fat to trans fat-rich partially hydrogenated vegetable oils have led to the premature death of millions.

When New York severely limited the amount of trans fat allowed to be served at restaurants, it offered a unique opportunity for researchers to study20 the effects on residents and compare rates of heart attack and stroke before and after the restriction.

Three or more years after the restrictions were imposed on specific counties in New York City, researchers found a 6.2% reduction in heart attacks and stroke in those counties compared to areas of the city where the restrictions on trans fat were not imposed.

Considering trans fat has proliferated in the American diet since the late 1950s, the unnecessary death toll attributable to trans fat likely numbers in the millions each year, nationwide. Similar findings have been reported by Danish researchers. Denmark was the first country to act on research demonstrating the dangerous health effects of trans fat.

The study,21 published in 2016, found that in the three years after trans fats were regulated, which nearly eliminated it from the Danish food supply, the annual mean death toll from cardiovascular disease was reduced by an average of 14.2 deaths per 100,000 people per year.

We’ve Known Trans Fat Takes a Toll on Cognition for Years

One can only guess how many people have lost their minds thanks to trans fat over these past decades. The 2019 Neurology study certainly wasn’t the first to demonstrate a clear link between trans fat consumption and dementia risk.

For example, in a 2012 study,22 Dr. Gene Bowman, assistant professor of neurology at Oregon Health and Science University, reported a strong correlation between trans fat and cognitive performance.

People with high levels of trans fat in their blood performed significantly worse in cognitive testing and had reduced brain volume. Bowman commented on the results to HuffPost:23

“It’s clear that trans fats are bad — both for your heart and now, we see, for your brain. So I would recommend that people stay away from all trans fats.

If you aren’t sure whether something has them, just look at the ingredients … if there’s vegetable shortening, partially hydrogenated anything … just put it down. That’s the big message here.”

Similarly, a 2015 study24 led by Dr. Beatrice Golomb found trans fat intake was linked to memory impairment in people under the age of 45. Each gram of trans fat consumed per day was linked to a 0.76 word decrease in word recall.

In the highest trans fat group, participants could recall on average 11 fewer words than those with the lowest trans fat intake, who had an average word recall of 86 words. The research, while unable to establish cause and effect, suggests trans fats may act as a pro-oxidant, contributing to oxidative stress that causes cellular damage.

Oxidized Omega-6 — Another Harmful Fat to Beware Of

It is clearly important to avoid trans fat, but as you will find out next year in an interview I am doing with Dr. Chris Knobbe about his Ancestral Health Symposium presentation, it is processed oils that are the primary culprit for nearly all Western diseases. Assiduously avoiding them is the key to staying healthy.

This is largely related to the oxidized omega-6 fat found in many processed foods, which may actually be even worse than trans fat. Now, omega-6 fat (linolenic acid) in and of itself is not the problem. Linoleic acid is also found in foods such as nuts, seeds and eggs, and is important for health.

The problem is oxidized omega-6 fat, and the fact that most people eat far too much of it. Intakes of omega 6 fat more than century ago were typically below 5 to 10 grams a day, and most of us now eat FAR more than that. For years, I’ve stressed the importance of balancing your omega-3 to omega-6 intake to protect your health.

Eating too much damaged omega-6 fat (found in abundance in processed vegetable oils) and too little marine-based omega-3 sets the stage not just for Alzheimer’s but also for diabetes, cardiovascular disease, rheumatoid arthritis, cancer and depression — and that’s the short list.

It is very easy to overeat omega-6 fats. I recently switched from macadamia nuts to pecans, which are also low in carbs and protein, but I did not realize pecans are loaded with omega-6 fats, relative to macadamia nuts. I only discovered this by using the terrific nutrient tracker Cronometer.com. I have since realized that is not wise to eat more than a handful of nuts and not every day.

I discuss some of the most significant hazards of omega-6-rich vegetable oils in “This Fat Is Actually Worse Than Trans Fat.”

The ideal ratio of omega-3 to omega-6 fats ranges from 1-to-1 to 1-to-5, but the typical Western diet tends to be between 1-to-20 and 1-to-50. Most people, especially Americans, are guilty of this lopsided omega-3 to omega-6 ratio, and to correct it, you typically need to do two things:

1.Significantly decrease intake of damaged omega-6 by avoiding processed foods and foods cooked in vegetable oil at high temperatures. A number of studies25,26 have found that people who regularly eat deep-fried foods have a significantly increased risk of stroke and death.

Common sources of harmful omega-6 to avoid include corn oil, canola oil, soy oil, hydrogenated or partially hydrogenated fats, margarine and shortening.

2.Increase your intake of animal-based omega-3 fats. Ideal sources include small fatty fish such as sardines, anchovies and herring, along with wild-caught Alaskan salmon, or a supplement such as krill oil.

Examples of Healthy Fats to Eat More Of

When it comes to dietary fats, remember this simple ground rule: Natural is best. The tips that follow can help ensure you’re eating the right fats for your health:

Use organic butter (preferably made from organic grass fed raw milk) instead of margarines and vegetable oil spreads — Butter is a healthy whole food that has received an unwarranted bad rap.

Ghee is even better, as you remove the milk solids that many have problems with. Ghee is pure fat with no carbs and is what I personally use. The best way to make it is to place it in a glass container in a dehydrator and don’t heat it higher than 100 degrees F. to preserve the quality.

You can suck off the milk solids with a glass baster. Once you have the ghee you don’t even need to refrigerate it as it is stable at room temperature for many weeks.

Use organic pastured pork lard for cooking and baking — A 2015 analysis27 of more than 1,000 raw foods ranked raw separated pork fat, also known as pork lard, as the eighth healthiest food on a list of 100.28 Valuable nutrients found in lard include:

Vitamin D29

Omega-3 fats30

Monounsaturated fats31 (the same fats found in avocados and olive oil32)

Saturated fats33

Choline34

Coconut oil is another excellent cooking oil that is loaded with health benefits.

To round out your healthy fat intake, be sure to eat raw fats, such as those from avocados, raw nuts, raw dairy products and olive oil. Also increase your animal-based omega-3 fat intake by eating more sardines, anchovies, mackerel, herring or wild-caught Alaskan salmon, or take a supplement such as krill oil.

Following my nutrition plan will automatically reduce your modified fat intake, as it will teach you to focus on healthy whole foods instead of processed junk food. You can also learn more in my interview with Dr. Cate Shanahan, author of “Deep Nutrition: Why Your Genes Need Traditional Food.”

In it, she delves deep into the pros and cons of various fats. The following chart was also created by her, which gives you a quick overview of the good, the bad and the ugly.

good fats oils- versus bad

Eating Right Can Help Prevent Dementia

In closing, remember that, by and large, it is your everyday lifestyle choices that will determine whether your brain will maintain its function throughout your lifetime, or degenerate with age into a potentially deadly neurological disease like Alzheimer’s.

With regard to diet specifically, key factors that will promote lifelong brain health include the following. For a list that also includes other suggested lifestyle modifications, see “How Excess Iron Raises Your Risk for Alzheimer’s.”

Eat real food, ideally organic — Avoid processed foods of all kinds, as they contain a number of ingredients harmful to your brain, including refined sugar, processed fructose, grains (particularly gluten), vegetable oils, trans fats, genetically engineered ingredients and pesticides.

Ideally, keep your added sugar to a minimum and your total fructose below 25 grams per day, or as low as 15 grams per day if you already have insulin/leptin resistance or any related disorders.

Opting for organic produce will help you avoid synthetic pesticides and herbicides. Most will also benefit from a gluten-free diet, as gluten makes your gut more permeable, which allows proteins to get into your bloodstream where they sensitize your immune system and promote inflammation and autoimmunity, both of which play a role in the development of Alzheimer’s.

Replace refined carbs with healthy fats — It’s important to realize that your brain actually does not need carbs and sugars; healthy fats such as saturated animal fats and animal-based omega-3 are far more critical for optimal brain function.

A cyclical ketogenic diet has the double advantage of both improving your insulin sensitivity and lowering your Alzheimer’s risk. When your body burns fat as its primary fuel, ketones are created, which not only burn very efficiently and are a superior fuel for your brain, but also generate fewer reactive oxygen species and less free radical damage.

Pay close attention to the kinds of fats you eat — avoid all trans fats or hydrogenated fats that have been modified in such a way to extend their shelf life. This includes margarine, vegetable oils and various butter-like spreads. For examples of healthy fats to add to your diet, see the section above.

Time-restricted eating in a six- to eight-hour window — Intermittent fasting is a powerful tool to jump-start your body into remembering how to burn fat and repair the insulin/leptin resistance that is a primary contributing factor for Alzheimer’s.
Keep your fasting insulin levels below 3 — If your insulin is high, you’re likely consuming too much sugar and need to cut back.
Optimize your omega-3 level — High intake of the omega-3 fats EPA and DHA help prevent cell damage caused by Alzheimer’s disease, thereby slowing its progression and lowering your risk of developing the disorder.

Ideally, get an omega-3 index test done once a year to make sure you’re in a healthy range. Your omega-3 index should be above 8% and your omega 6-to-3 ratio between 1-to-1 to 5-to-1.

Optimize your vitamin D level — Sufficient vitamin D is imperative for proper functioning of your immune system to combat inflammation associated with Alzheimer’s and, indeed, research shows people living in northern latitudes have higher rates of death from dementia and Alzheimer’s than those living in sunnier areas, suggesting vitamin D and/or sun exposure are important factors.

If you are unable to get sufficient amounts of sun exposure, take daily supplemental vitamin D3 to reach and maintain a blood level of 60 to 80 ng/mL. That said, it’s important to recognize that sun exposure is important for reasons unrelated to vitamin D.

Your brain responds to the near-infrared light in sunlight in a process called photobiomodulation. Research shows near-infrared stimulation of the brain boosts cognition and reduces symptoms of Alzheimer’s, including more advanced stages of the disease.

Delivering near-infrared light to the compromised mitochondria synthesizes gene transcription factors that trigger cellular repair, and your brain is one of the most mitochondrial-dense organs in your body.

Optimize your magnesium levels — Preliminary research strongly suggests a decrease in Alzheimer symptoms with increased levels of magnesium in the brain. Keep in mind that the only magnesium supplement that appears to be able to cross the blood-brain barrier is magnesium threonate.
Vitamin B12 — According to a 2010 study published in the journal Neurology,35,36 people who consume foods rich in B12 may reduce their risk of Alzheimer’s in their later years. Very high doses of B vitamins have also been found to reduce memory loss by preventing brain shrinkage.37
Eat plenty of nitrate-rich foods — Beets and other nitrate-rich foods such as arugula provide powerful benefits for your brain and may be a powerful ally in the fight against Alzheimer’s disease.38

Your body transforms plant-based nitrates into nitric oxide,39 which enhances oxygenation, has beneficial impacts on your circulatory and immune systems, and serves as a signaling or messenger molecule in every cell of your body.

The betanin in beets also helps prevent oxidation, particularly oxidation caused when the beta-amyloid is bound to copper, which may help prevent the misfolding and aggregation of amyloid beta.40

Previous research41 has also shown raw beet juice helps improve neuroplasticity, primarily by increasing blood flow and tissue oxygenation. Nitric oxide, in its capacity as a signaling molecule, allows your brain cells to communicate with each other better. Importantly, the beets boosted oxygenation of the somatomotor cortex, a brain area that is often affected in the early stages of dementia.

Optimize your gut flora — To do this, avoid processed foods, antibiotics and antibacterial products, fluoridated and chlorinated water, and be sure to eat traditionally fermented and cultured foods, along with a high-quality probiotic if needed.

Remember that eating factory farmed meats will provide you with traces of antibiotics in each bite. Factory farmed meats are also a suspected route of prions, which are yet another culprit in Alzheimer’s. You can learn more about this in “Study Claims Alzheimer’s Disease Is a Double-Prion Disorder.”

Novel Treatments Are Being Explored

Diagnostic guidance and core treatment strategies are detailed in my interview with Dr. Dale Bredesen, featured in “ReCODE: The Reversal of Cognitive Decline.” (You can also download Bredesen’s full-text case paper,42 which details his ReCODE treatment program.)

On a side note, two promising treatment alternatives for Alzheimer’s include photobiomodulation, discussed in “Healing the Body With Photobiomodulation,” and a novel treatment developed at MIT using flickering lights and low frequency sound to stimulate gamma frequencies in the brain,43 which appears to reduce plaque formation.44

MIT neuroscientist Li-Huei Tsai discussed the experiments at a recent Society for Neuroscience meeting, saying the therapy appears to improve survival and health of neurons, improving neuronal connectivity and dilating blood vessels in the brain. His team is now investigating whether it might in fact slow Alzheimer’s disease in humans.45

Over the years, as more and more drug trials have failed to find an answer to Alzheimer’s, researchers are increasingly starting to realize that to be able to address this disease with any measure of success, we have to go back to basics.

There’s a wealth of data showing diet and lifestyle factors are where it’s at when it comes to Alzheimer’s prevention and treatment, and this puts the power right into your own hands. There’s a lot you can do to minimize your risk, and cleaning up your diet is the best place to start.

– Sources and References

Do we need vaccinations?

By LeanMachine, including some content by Dr. Mercola, edited and added to by LeanMachine, Health Researcher.

First, let me make this clear: LeanMachine is not anti-vaccine.
True, I have not had a vaccination in around 10 years prior to writing this article, and probably never will. There are some vaccines which can help in some situations for some people, while others can be dangerous or deadly.
However, everyone has the right to full disclosure of the risks versus benefits of anything they allow into their body. We cannot tolerate being lied to about these risks and benefits, and lies from the Drug Industy is becoming normal in our modern world to protect their enormous profits.
We all have a choice of what food we eat, but it seems as time goes on, we are dictated to by Governments, operating on advice from money-driven drug companies, what is injected into us.
We usually do not have a choice in refusing vaccinations. If we refuse such injections, it can deny us the right to the job we want, or the school we can go to. We cannot even sue the drug companies or doctors in the USA as Government legislation protects them when they make us sick or even kill us.
When the Government takes away our right to decide what goes into our bodies, the Government owns us, as they own real estate, cash and cattle. In a “free” society, this cannot be tolerated.
And there are ZERO follow-ups after vaccinations to determine what effect vaccinations have on our general health.

The Nuremberg Code

Vaccinations are technically illegal in Australia.
Australia is a signatory to the Nuremberg Code, which was developed before, during and after the Second World War, when Nazi doctors were using humans as guinea-pigs for all sorts of bizarre experiments without the consent of the subject.
The code states:

  1. Required is the voluntary, well-informed, understanding consent of the human subject in a full legal capacity.
  2. The experiment should aim at positive results for society that cannot be procured in some other way.
  3. It should be based on previous knowledge (e.g., an expectation derived from animal experiments) that justifies the experiment.
  4. The experiment should be set up in a way that avoids unnecessary physical and mental suffering and injuries.
  5. It should not be conducted when there is any reason to believe that it implies a risk of death or disabling injury.
  6. The risks of the experiment should be in proportion to (that is, not exceed) the expected humanitarian benefits.
  7. Preparations and facilities must be provided that adequately protect the subjects against the experiment’s risks.
  8. The staff who conduct or take part in the experiment must be fully trained and scientifically qualified.
  9. The human subjects must be free to immediately quit the experiment at any point when they feel physically or mentally unable to go on.
  10. Likewise, the medical staff must stop the experiment at any point when they observe that continuation would be dangerous.

Of course, ALL vaccinations are in violation of this code. There has been no vaccination produced in decades where a large, double-blind, placebo-controlled independent study has been carried out scientifically to prove the benefit and seek possible side-effects.
Governments who legislate that the refusal of a vaccination means no job, no unemployement benefit, no school, no child care, etc, are in direct violation of the code.
Many vaccinations have killed or maimed for life, many innocent babies, children and adults.

The Australian Vaccine Schedule

The link below points to the vaccination schedule in 2017. Doctors, hospitals, nurses and others are obliged to carry out vaccinations according to the schedule.
Australian Government Vaccine Schedule
Problems with this schedule:
At birth, babies must be given a Hepatitis B vaccination, but why?
We can get Hepatitis B from a dirty needle when using street drugs, or having casual, unprotected sex with multiple partners of unknown health.
How many babies, just hours old, fit this criteria?
Any why give a baby, with an underdeveloped immune system, a toxic injection?
This is outrageous and criminal, and parents must refuse, before the birth, as this often happens without the knowledge or the consent of the parents, or the baby!

Lies from the CDC (Centers for Disease Control and Prevention)

The CDC in the USA is supposed to protect us from disease, or so you may think. Australia generally uses the guidelines from the USA, so we should get the same protection?
Nothing could be further from the truth, with profit greed by the big drug companies overtaking the truth.
For decades, studies have shown that there is a correlation between Autism and vaccinations, but the big drug companies and Governments have always denied any relationship. Advice from Governments has always been that vaccinations do not cause autism.
However, in May 2016, after over a hundred FOIA (Freedom of Information Act) requests, the CDC was forced to release the proof they have known for years: That a vaccine preservative CAUSES AUTISM!
The preservative is Thimerosal, which was banned for use in children in 1999, but still used in more than 60 vaccines, and proven to cause autism.
Scientists have been attempting to alert the public, but their statements have been dismissed, or even made appear foolish by the corrupt pharmaceutical industry.
Every vaccination has an adjuvant, which has dual properties: Fist as a preservative, second to cause inflammation.
Inflammation is deemed necessary, because the fever forces the body to view this injected foreign material as an invader, and build immune system antibodies to the invaders.
While this can work in the majority of cases, it often fails in cases where:

  • The patient has a compromised immune system
  • The patient has an abnormal allergy response
  • The patient has been taking panadol (paracetamol, or in the USA, acetaminophen)

Vaccine Adjuvants

why are aluminium salts effective as adjuvants and why do we use them? The latter is easily answered. They are extremely cheap, essentially they cost nothing relative to other vaccine constituents, and there are absolutely no regulations as to the use of aluminium salts, either as adjuvants or otherwise. Adjuvants, including aluminium-based, are effective because of their toxicity at the vaccine injection site. One of the most effective adjuvants is Freund’s Complete Adjuvant (a preparation of dried and inactivated mycobacteria) but this adjuvant is too toxic to be used in human vaccinations. Aluminium salts are the most widely used adjuvants because their toxicity at the injection site is deemed acceptable in the light of the advantage gained from vaccination against the particular antigen. The toxicity induced by aluminium adjuvants at injection sites is almost certainly due to the free aluminium cation, Al3+, which is released from the injected aluminium salt. The cell death which is a consequence of the toxicity results in an inflammatory response and this is the origin of the swollen red tissue at the injection site almost immediately following vaccination. The toxicity of an aluminium adjuvant depends upon the aluminium salt with aluminium hydroxyphosphate (known commercially as AdjuPhos™) being more toxic at the injection site than aluminium oxyhydroxide (known commercially as AlHydrogel™). The aluminium adjuvant used in the Gardasil HPV vaccine is a sulphated version of aluminium hydroxyphosphate and is likely, based upon what we know about aluminium chemistry, to be even more toxic. Unfortunately, Merck, the manufacturers of this adjuvant have not made it available for any independent analyses, never mind safety testing. The visual evidence of the toxicity of aluminium adjuvants at the injection site is limited by their intramuscular administration (the adjuvant is hidden away in the muscle tissue) while their actual injection site toxicity is experienced by many as significant muscular pain, and associated events, in the receiving limb which can last for hours and even days. However, the role of the injection site toxicity is to attract a variety of immune-responsive cells and these cells proceed to load up their cell cytoplasm with particles of aluminium adjuvant as well as antigen, the latter may or may not be associated with the adjuvant material. Thereafter, dogma dictates that the delivery of antigen to lymph nodes initiates antigen-specific adaptive immunity. We have recently learned that the migratory cells which populate the injection site following vaccination are capable of loading up their cell cytoplasm with particles of aluminium adjuvant without these particles having any immediate effect upon cell viability . These immune-responsive cells are subsequently found in lymph nodes but they are also capable of transporting their cargo of aluminium throughout the body including gaining access to the brain. These aluminium-loaded migratory cells remain viable in the shorter term because the particulate aluminium salt in their cytoplasm is enclosed in membrane-bound vesicles. However, these vesicles undergo a progressive acidification which in turn dissolves the enclosed aluminium salt to release biologically reactive Al3+ which will eventually cause the membrane-bound vesicle to rupture and consequently release large amounts of biologically available aluminium into the cell cytoplasm. The inevitable consequence of this is cell death and where this cell death occurs will simply depend upon the trajectory of the cells upon leaving the vaccine injection site. Theoretically at least this is a mechanism whereby a significant, indeed acute, amount of aluminium could be released into areas distant from the injection site such as brain tissue. It is undeniable that a small proportion of individuals receiving vaccines which include aluminium adjuvants experience what have been called severe adverse events and such ‘events’ include brain encephalopathies. These severe adverse events are almost certainly caused by aluminium adjuvants and recent research showing how immune-responsive cells load up their cytoplasm with particulates of aluminium now offers mechanistic insight into how aluminium adjuvants are not only always toxic at the vaccine injection site but how they can occasionally be toxic at distant sites in the body too. Why some individuals are more susceptible to toxicity due to aluminium adjuvants is the subject of ongoing research.

Dangers of Paracetamol

Doctors still mistakenly advise parents to give their child paracetamol (Paracetamol, Panadol) before any vaccination, which is a BIG MISTAKE.
Paracetamol reduces the fever, in turn reducing the body’s natural immune response to the vaccination, reducing the effectiveness of the production of antibodies.
Even worse, a natural enzyme in the body in combination with Paracetamol, destroys Glutathione, the body’s MASTER ANTIOXIDANT.
Destruction of Glutathione compromises our immune system makes us much more susceptible to almost any disease.
When Glutathione levels drop to around 30% of normal, liver cell death starts, and other conditions start also because of low Glutathione.
Poisoning can occur with an accidental or deliberate overdose, or even continued use at the recommended dose.
Paracetamol poisoning requires urgent hospital treatment. Symptoms often do not appear before 24 hours after ingestion, and NAC (N-Acetyl-Cysteine) is administered. NAC is available as a supplement, but do not try to treat any poisoning at home!

Cuba

In Cuba, where there is over 99% vaccination rate for children, more than most of the USA, there is an Autism rate of around 1 in 12,000 to 1 in 60,000. The data reporting in Cuba may influence the numbers, but when we compare the USA rate of 1 in 45, then clearly there is a problem in the USA. A few decades ago, Autism was almost unknown in the USA and Australia.
What is the difference? Why are USA children over a thousand times more likely to get Autism than Cuban children? Part of the answer is:
In Cuba, Paracetamol (acetaminophen) is prescription-only, where in Australia and the USA anyone can buy it almost anywhere with no prescription.
Apart from apparently causing Autism, Paracetamol also causes liver damage. Because this dangerous drug is marketed as “Safe and Effective” there is a public perception that a small overdose would not be harmful, but in fact a single pill causes harm by depleting Glutathione, and it is true to say that most of the people on the liver transplant waiting list are there because of a paracetamol overdose!
The second part of the answer:
In Cuba, there is a high vaccination rate, but the difference is that Cuba makes it’s own vaccines, there are no large drug companies seeking dollar profit only, so the quality of vaccines is higher, and the vaccine schedule is much less aggressive, with Cuban children under 5 receiving some 11 vaccinations, compared with 40 in the USA.
So with so many vaccinations in the USA, the children must be healthier, we would think?
Not so. In fact, the USA has the highest death rate of children under five, than all other developed countries in the world!

Dangers of Adjuvants

Adjuvants are added to vaccines to supposedly make them more effective.
Adjuvants are mixed with an antigen from a virus or bacteria to deliberately create a greater inflammatory immune response, theoretically providing a higher response of protective antibodies.

Thimerosal Adjuvant

Thimerosal is a vaccine adjuvant that contains mercury, which is a human carcinogen and:

  • Causes Autism and many other conditions affecting the brain
  • Causes Cancer
  • Is a mutagen (interferes with DNA)
  • Is a teratogen (causes birth defects)
  • Reduces immunity
  • Causes Alzheimer’s Disease and other brain issues

Thimerosal metabolises into toxic, dangerous methylmercury, then converted to inorganic mercury which is even more harmful and very hard for the body to excrete.
For those with a compromised immune system already, this destroys much of an already weakened immune system, leading to many diseases.

Aluminium Adjuvant

Most, if not all inactivated vaccines use aluminium (aluminum in the USA) as an adjuvant.
The problem with aluminium is that it is toxic to the human body, believed to cause Alzheimer’s and many other brain diseases. When aluminium is swallowed, less than 1.5% is absorbed by the body. But if injected into muscle tissue, as happens in a normal vaccination, then 100% is absorbed into the body. Add to this the very high number of vaccinations we are told our children need, plus extra aluminium from food and drink containers, cooking utensils, foil food wraps, etc, this becomes way too much.

How are vaccines made?

Depends on the type of vaccine.

The Standard Flu Shot

The standard process uses 500,000 fertilized chicken eggs every day for about eight months, so hundreds of millions of fertilised eggs are used every year, “mini incubators” for cultured viruses. When the chick embryos are eleven days old, the egg white (the amniotic fluid) is injected with a drop of solution containing the virus. After a few days, the viral suspension is then centrifuged, which removes much, but not all, chicken tissue and blood. Whatever remaining egg protein and blood is included in the final vaccine. This is why those with an allergy to eggs are advised not to receive a flu shot.
Given the very large numbers of eggs required, do you think they would select only the most expensive pasture-raised free range eggs? I think not. They would buy the cheapest eggs possible – factory farmed cage eggs, where the chickens are invariably sick, never see the light of day, are loaded up with cheap antibiotics to keep them alive long enough for them to produce the eggs, and would undoubtedly be full of unknown viruses. Salmonella is rampant among factory-farmed eggs, and the different strains of Salmonella cause illnesses such as typhoid fever, paratyphoid fever, and food poisoning.
The antibiotics destroy some bacteria, but this tends to help proliferate the antibiotic-resistant bacteria, and the chickens are then even more susceptible to viruses, because antibiotics destroy beneficial gut bacteria which provide immunity in chickens as well as humans.

Cell Line Technologies

This is another vaccine manufacturing method, using cells and tissues for growing vaccine viruses, used since the 1950’s.
In June 2014, the all-clear was given to use cells from the kidney of a Cocker Spaniel dog which died in 1958 to make the Flu and other vaccines.
Cells from animals used in vaccines includes:

  • Calf lymph for Smallpox vaccines
  • Mouse brain cells for Japanese Encephalitis vaccines
  • MRC-5 and WI-38 cells from aborted human fetal tissue were developed in the 1960’s and still used for Rubella, Chickenpox, Hepatitis A and Shingles vaccines
  • African green monkey cells (AGMK cells) for polio vaccines – see below

Still want to get a flu shot?

African green monkey cells (AGMK cells) for polio vaccines caused the HIV/AIDS virus

More Lies from the CDC (Centers for Disease Control)

New science which almost certainly proves that the HIV/AIDS virus was NOT caused by Africans eating infected monkeys, but from a Polio vaccine made from African green monkey cells injected into more than one million Africans, giving them HIV/AIDS directly, which has then spread to the rest of the world via blood transfusions, anal sex, dirty needles and other methods similar to vaccinations.
These monkeys were already infected with the SIR virus which transmuted into the HIV/AIDS virus in humans.
Of course, the medical profession denied this, and published many documents claiming why this was impossible, but modern science has blown major holes in this “evidence” as an obvious cover-up.
As the drug industry changes from egg-incubation methods to animal cell incubation, how do we know the effects on humans and how the virus will transmutate and spread?
Obviously, no one knows. No one cares. All the drug companies are concerned about is making money, not healing people. If people get sick from their vaccines, the drug companies get paid to make yet more vaccines. Even in cases where they can protect people from a certain disease, who knows what other diseases they are infecting people with?

Truth about Polio

India introduced an Injectable Polio Vaccine (IPV) in the routine immunisation programme for all children under 5 years old, claiming it “will be an important step in the Polio Endgame Strategy”, This appeared to work: India has not reported a single case of polio caused by the wild polio virus (WPV) since January 2012.
FAKE NEWS – There has been around 50,000 cases of flaccid paralysis, which is exactly like polio!
It is now called “Vaccine Derived Polio Virus (VDPV)” in medical literature.
Yes, the polio vaccine causes polio, but to protect the drug manufacturers and the politicians, they call this condition “Acute Flaccid Paralysis” or AFP.
Symptoms of AFP include fever, sudden muscle weakness in one or more limbs, just like polio. Many things cause AFP, but one cause is the polio vaccine!
AFP is less common in Western countries, because of two things; better sanitation and cleaner drinking water.
According to the American journal Pediatrics, there is an undeniable link between the increase in incidence of NPAFP (non-polio AFP) and the number of Oral Polio Vaccine (OPV) doses delivered in any region. OPV contains an attenuated (weakened) vaccine-virus. The weak form of the polio virus is used to activate an immune response in the body, which then protects the child when challenged by WPV. But when a child is immunised with OPV, the weakened vaccine-virus replicates in the intestine. During this time, the vaccine-virus is also excreted. In areas of inadequate sanitation, this excreted vaccine-virus can quickly spread in the community and infect children with low immunity. This excreted vaccine undergoes genetic changes as it circulates in the community and causes VDPV.
The government states that VDPV is still comparatively rare, as it has to circulate for a long time in the community of under-immunised or poor-immune children before it can infect and cause paralysis in someone.
The government’s only strategy is the addition of Inactivated polio vaccine (IPV)
A 2005 study in the Indian Journal of Medical Research on NPAFP found that a fifth of cases of NPAFP were reported from Uttar Pradesh. Researchers found that 35.2% of children with AFP had paralysis and 8.5 per cent died, about double the rate of paralysis and death if the child had the original Polio!
The government is still basking in the glory of one of its rare public health achievements for eradicating polio, while cases of flaccid paralysis have seen a huge resurgence.
Nearly 50,000 children fall prey to polio-like flaccid paralysis every year, with over 15,000 paralysed and over 4,000 die!

Reported side effects from vaccinations

Most side effects go unreported.
If a patient sees a doctor for an illness after a vaccination, the patient usually does not make the connection, and if they do, the doctor often refuses to admit there may be a connection. Even though laws in the USA prevent doctors from being sued because of injury or death from a vaccination, they are naturally always reluctant to admit that their action caused the injury or death.
If we view studies on reported side effects, then it is likely that unreported side effects may range from double to hundreds of times the reported side effects, especially mild side-effects like a fever, rash, feeling unwell, etc which the doctor will say is “probably just a virus” or “a coincidence”.
Guillian-Barre Syndrome is a devastating condition, shown to be caused by 5 in every million vaccinations. Perhaps only a small number, but devastating if we are one of those 5.
Article here: www.greenmedinfo.com/article/risk-guillain-barr-syndrome-after-2010-2011-influenza-vaccination

The Flu vaccine causes six times more respiratory infections

We are told by Government health “experts” that: “The flu vaccine protects the very young and the very old, the groups most likely to suffer serious respiratory complications from the flu.”
And they say: “It is important everyone else get the flu vaccine to further protect these vulnerable segments of the population.”
But these statements are FALSE.
If the flu vaccine really works, then a non-vaccinated person should not be able to infect any vaccinated person, young or old.
Of course, the vaccine does NOT work.
Governments force everyone working in haspitals, schools, child care, prisons, welfare, etc to have the flu shot, but the results speak for themselves. They still get the flu just like the rest of the population, but they get it WORSE than the unvaccinated group, who get the flu, recover, and have then a natural immunity to help prevent future attacks when the flu virus develops into a different strain, and reduce severity of future attacks.
Evidence proves the flu vaccine is a failure, ESPECIALLY in the very old, and the 2014-2015 annual flu vaccine in the USA does not cover half of the flu viruses in circulation. Even in years when the CDC (Centers for Disease Control and Prevention) does get it better, vaccination does not protect the elderly against serious flu complications. The typical success rate for seniors is claimed to be 30% (which I call a 70% failure rate), even if we can believe them. Children now do not get the flu shot because of an alarming number of cases of severe health issues after the shot.
Governments also claim that if anyone still gets the flu after being vaccinated, then their symptoms will be milder, and they will recover around one day earlier. Of course, they omit to tell us that if we have a glass of lemon juice and water every day and forget the flu shot, we are less likely to get the flu at all, and if we do, the symptoms will be milder, and we will recover at least a day earlier, and our risk of cancer and Alzheimer’s disease will be substantially reduced! And if we add vitamin C, vitamin D3, vitamin A, probiotics, and stick to a healthy diet and avoid antibiotics, we will probably NOT get the flu at all!
LeanMachine changed his lifestyle completely at age 63, and 8 years later at age 71, has not had a cold, flu, any other illness, not even a headache!
There are very few studies on preventing disease without vaccinations, as there is no money in it for the big drug companies, but LeanMachine has embodied all he has learned in 8 years of research in a one-person study, proving to himself, if no one else, that vaccinations are not necessary.

The Flu vaccine causes miscarriages

Recent studies have shown that women who have the flu shot in at least two consecutive years, have increased risk of spontaneious abortions (Miscarriages) compare to women who do not get the shot.
This means that thousands of would-be babies have never been born alive and well, a disaster for the parents involved.
The drug companies put their spin on this situation, but no matter how they manipulate the data, the results come out the same.
This study was carried out by the CDC, who are pawns to the drug industry, so an independent study would have come out even worse.

Are non-vaccinated Children Healthier?

The flu shot effect on children:

The U.S. government still refuses to carry out a single study comparing vaccinated to non-vaccinated children, because “it would be unethical to deprive any child of the vaccine.”
However, nothing can be ethical without scientific validation. It’s a good thing we have all those full-time, non-physician bioethicists guiding the government and the academic medical research complex. Maybe they should all go back to Bioethics 101.
Fortunately, in 2012, scientists in Hong Kong did conduct a scientific test of vaccination on children.
It’s probably one of the few, if not the only, true scientific study on the effectiveness of flu vaccines in children conducted in recent years, and it revealed the absurdity of vaccination “science.”
The study was a double-blind, placebo-controlled trial, the same kind designed to study drugs before they are approved.
Of course, mainstream medical researchers insist upon using this methodology to assess natural therapies too, even when it is completely inadequate and inappropriate. But in this case, the design is perfect for demonstrating the effectiveness of a vaccine, or lack thereof, as it turned out.
Researchers divided the children into two groups.
The first group received the trivalent flu vaccine (meaning the vaccine contained three strains of influenza circulating that season).
The second group received a salt solution, a genuinely inactive treatment, as the placebo.
(Curiously, most vaccine trials use active placebos, or substances already found in the vaccines, which makes the results meaningless, but this fact is almost never revealed.)
Then, they followed the children for about nine months.
At the end of the trial period, the researchers said they found no “statistically significant” difference in the risk of influenza infection between the two groups. In other words, they found NO BENEFIT from the vaccine.
But when you look at the actual numbers, it is a different story.
In fact, 116 children in the vaccinated group caught the flu. But only 88 children in the placebo group got it. In other words, nearly 25 percent more children who received the flu vaccine got the flu compared to children who didn’t get the vaccine. I would hardly call that difference “statistically insignificant.”
And another interesting point…
The vaccinated children had evidence in their blood of antibodies against the flu, as you would expect when you inject a vaccine. The study authors suggested that the presence of these antibodies provided benefits to the children. But if the children still had the same or greater risk of actually getting the flu, then what difference did it make?
Clearly, the vaccine did NOT protect the children from getting sick in other ways either. In fact, the vaccinated group ended up getting almost six times more respiratory infections. To be more specific, the vaccinated group experienced 230 cases of rhinovirus (common cold) and the non-vaccinated placebo group experienced only 59 cases. That’s 75 percent fewer cases!
Furthermore, there were 160 cases of Coxsackie/Echovirus (Enterovirus, causing bronchiolitis, bronchitis and exacerbations of asthma) in the vaccinated group, but ZERO cases in the non-vaccinated placebo group.
Among other respiratory viruses, there were 97 in the vaccinated and only 88 in the placebo.
Of course, the common cold is not a life-threatening illness. Coxsackie and Echovirus usually just cause minor respiratory symptoms, although they both can also cause hepatitis, heart disorders, meningitis, and paralysis.
But these infections certainly aren’t enjoyable for children or their parents, amd often lead to parents administering dangerous medications, like acetaminophen (also called Panadol, Paracetamol, Tylenol, etc), to alleviate their child’s symptoms. So why increase a child’s chances of coming down with one of these “harmless” viruses? And if viruses are harmless, then why vaccinate in the first place?
The study authors concluded in their report that the trivalent influenza vaccine “could increase influenza immunity” even though their results showed it INCREASED actual flu cases, and clearly reduced the children’s immunity against non-influenza respiratory viruses. They blamed this “unusual” finding of increased risk on some “unknown” biological mechanism.
“Unknown”? It is NOT unknown. In fact, vaccines interfere with normal immune system responses, so interfere with the ability to fight other infections. We have known about this phenomenon in virology for more than half a century.
On the contrary, this study gives us many “known” conclusions!
First, influenza vaccines provide NO BENEFIT.
Second, they carry a huge risk of other respiratory illnesses.
Third, they likely harm the normal immune response.
But the facts are up against the alphabet soup of CDC, FDA and NIH, as well as WHO, all heavily influenced by the big drug companies.
Henri Pasteur, a true pioneer of effective vaccination, would be rolling over in his grave at the current state of affairs. Or, perhaps shouting, “Sacre bleu.”

Too many vaccinations?

Children in the USA are expected to get 48 doses of 14 vaccines by the time they’re just 6 years old. By age 18, federal public health officials say they should have gotten a total of 69 doses of 16 vaccines from day of birth to age 18. This “prescription” is supposed to keep children healthy and free of disease, but, incredible as it may sound, no scientific study has ever proven this to be the case.
The cost to immunize a child in 1985 when Dr Mercola started practice was about US$80. In 2016, largely because in the increase in the number of vaccines, plus general cost increases, that cost has risen to US$2,200. This is an ENORMOUS increase, and you can begin to imagine the amount of revenue that is being generated from forcing mandatory vaccinations on the entire population.
It seems painfully obvious that in order to justify the expense and the risk of side effects inherent in the U.S. vaccination schedule, it would have to be proven that this series of shots is actually effective, safe and better than receiving no shots at all. The only way to do this would be to compare the health of vaccinated children with that of non-vaccinated children, and see which group fares better.
But such a common-sense study comparing the health of vaccinated vs. non-vaccinated children has never been done in the United States for any vaccination!
That is, until now…

Vaccinated vs. non-vaccinated: Survey Reveals Who’s Healthier

In December 2010, a survey was initiated by www.vaccineinjury.info to compare the health of vaccinated children with non-vaccinated children. To date over 7,850 surveys have been submitted, and the study is ongoing, so if you have a non-vaccinated child (or are non-vaccinated yourself) and would like to submit his or her health data, you can do so here.
Though this is obviously not a double-blind controlled study, and depends on the individuals submitting the data to give accurate information, it is still incredibly revealing.
So far, the results show:

Health Condition Prevalence in Vaccinated Children Prevalence in non-vaccinated Children
Allergies 40% report at least one allergy Less than 10%
Asthma 6% 2.5%
Hayfever 10.7% of German children 2.5%
Neurodermatitis (an autoimmune disorder) 13% of German children 7%
ADHD 8% of German children, and another nearly 6% with borderline cases 1-2%
Middle ear infections 11% of German children Less than 0.5%
Sinusitis Over 32% of German children Less than 1%
Autism Approximately 1 in 100 Only 4 cases out of 7,800+ surveys (one child tested very high for metals, and another’s mother tested very high for mercury)

In the chart below, from www.vaccineinjury.info, we can see a direct comparison of health data from the KiGGs study (The German Health Interview and Examination Survey for Children and Adolescents) versus the data from non-vaccinated children taking part in VaccineInjury.info’s survey:
Vaccine Injury Survey

Vaccine Autism Connection

Although nearly every major vaccine “expert” will vehemently deny the connection between autism and vaccines, there is no question in my mind at all that it exists. They quote seriously flawed and biased research to support their position, and because it is published in scientific journals (which are in large part funded by the drug companies), most health care professionals and the public believe it.
However, objective analysis, like the one featured here, show what nearly every other study shows:
That the incidence of autism has increased to 1 in 100 in those that were vaccinated.
No one disagrees with this. What is fascinating is that the incidence in the non-vaccinated group was about one in 2,000 which is still more than in the past, but TWENTY times lower risk than in the vaccinated group.
Fortunately it appears that we do have a risk factor and a test that you can use that will help you understand if your child is at risk for autism.
After all, 99 kids in 100 did NOT get autism. So wouldn’t it be great to identify the risk factor BEFORE you vaccinate your child and correct it? Remember, we are all about SAFE vaccine policies and radically lowering their risk. It is up to parents to review the evidence and make the choice, but if you decide to vaccinate I could not more strongly recommend listening to the interview Dr Mercola did with Dr. McBride, and follow her screening and treatment recommendations.

Make Sure You Believe in Artificial Immunity Before You Vaccinate

It is quite clear from the data above that vaccinated children are not healthier than their non-vaccinated peers, despite what the public health agencies would like you to believe. What is not clear is why vaccinated children appear to be sicker, and although this survey does not establish cause and effect, it does suggest that the vaccinations themselves are involved.
There are numerous mechanisms by which a vaccine could potentially damage your health:
Contaminationadjuvants, and preservatives like mercury, to name just a few. But an often-overlooked component is the very way in which they are intended to build your immunity, which is artificially. The presumed intent of a vaccination is to help you build immunity to potentially harmful organisms that cause illness and disease. However, your body’s immune system is already designed to do this in response to organisms that invade your body naturally.
Most disease-causing organisms enter your body through the mucous membranes of your nose, mouth, pulmonary system or your digestive tract, NOT through an injection.
These mucous membranes have their own immune system, called the IgA immune system. It is a different system from the one activated when a vaccine is injected into the body. Our IgA immune system is our first line of defence, by fighting off invading organisms at the entry points, reducing or even eliminating the need for activation of the body’s immune system.
However, when a virus is injected into your body in a vaccine, and especially when combined with an immune adjuvant, our IgA immune system is bypassed and our body’s immune system kicks into high gear in response to the vaccination. Adjuvants can trigger unwanted immune responses, as they can cause your immune system to over-react to the introduction of the organism you’re being vaccinated against.
According to Barbara Loe Fisher, president and co-founder of the National Vaccine Information Center:
“Vaccines are supposed to fool your body’s immune system into producing antibodies to resist viral and bacterial infection in the same way that actually having the disease usually produces immunity to future infection.
But vaccines atypically introduce into the human body lab-altered live viruses and killed bacteria along with chemicals, metals, drugs and other additives such as formaldehyde, aluminum, mercury, monosodium glutamate, sodium phosphate, phenoxyethanol, gelatin, sulfites, yeast protein, antibiotics as well as unknown amounts of RNA and DNA from animal and human cell tissue cultures.
Whereas natural recovery from many infectious diseases usually stimulates lifetime immunity, vaccines only provide temporary protection and most vaccines require “booster” doses to extend vaccine-induced artificial immunity.
The fact that man-made vaccines cannot replicate the body’s natural experience with the disease is one of the key points of contention between those who insist that mankind cannot live without mass use of multiple vaccines and those who believe that mankind’s biological integrity will be severely compromised by their continued use.”

Why did Australia, Europe, and the U.S. Ban the Flu Vaccine for Children Under 5?

In 2010, Australia temporarily suspended its seasonal flu program for children under the age of five after detecting an abnormal number of side effects within 12 hours of vaccination, compared to previous years.
The vaccine in question was Fluvax, manufactured by CSL Limited. Side effects included high fevers and seizures.
One infant also lapsed into a coma.
After a three-month investigation, the Australian Department of Health resumed seasonal flu vaccinations for young children, stating that “the higher than usual occurrence of fever and febrile convulsions appears to be confined to the vaccine Fluvax” and advised parents to continue vaccinating their children with another brand. The link to this study has now disappeared…
Now, however, it’s being reported that an 18-month investigation by CSL found the reactions appear to have occurred due to the combination of swine flu and seasonal flu strains in the vaccine, a mix that had never before been concocted.
CSL reported:
“Our scientific studies indicate that the interaction between the particular virus strains used in the 2010 … vaccine contributed to the reactions, but we are still working to understand the how and why.”
The Fluvax vaccine has now been banned for children under 5 in Australia, Europe and the United States due to the increased rate of convulsions in children who received the vaccine. Meanwhile, the swine flu vaccine even on its own has been linked to unusual side effects as well. In fact, new data from Sweden, released at the end of June, show the vaccine raises the risk of narcolepsy by nearly 660 percent!
It is very clear that vaccines do not cause problems for everyone who receives them, but when they do, it can be an unmitigated disaster. The reaction may be acute, such as fever or swelling, or it may be chronic and show up much later, such as narcolepsy or an increased propensity for allergies and autoimmune diseases. Long-term health outcomes post-vaccination are typically not studied, so surveys like the one noted above are now offering the first real look at the potential long-term health risks of vaccination.
Remember that when you or your child is injured by a vaccine, the risks are 100 percent, and you will be left to deal with the consequences.

FluMist Worthless Against Influenza

The Washington Post wrote about why the FluMist vaccine suddenly stopped working.
This spray form of the flu vaccine was preferred over the injected form for children between 2 and 8 years old. FluMIst is a “live attenuated vaccine”, meaning it contains a live but weakened version of the flu virus.
However, a CDC advisory panel found that the nasal spray “was so ineffective that it should not be used by anyone during the 2016 to 2017 season.”
Data from the 2015 Winter showed FluMist to be only 3% effective in 2 to 17 year old children. Nearly all who received FluMist risked their health for nearly zero benefit!
MedImmune are the makers of FluMist, and have not determined why their product fails.
The Washington Post reported:
“In any given flu season, vaccine effectiveness varies. One factor is how well the vaccines match the virus that is actually prevalent. Other factors include the age and general health of the recipient. In the overall population, the CDC says studies show vaccines can reduce the risk of flu by about 50 to 60 percent when the vaccines are well matched. Now, researchers are trying to find a common factor behind FluMist’s recent incidents of poor performance.”
Researchers will attempt discover if the flu vaccine loses effectiveness when given to a child who has been previously vaccinated against influenza several times.

I consider that the vaccine makers do not know as much about their products as they say, but despite this, they insist that vaccines are beneficial and worth almost any risk to the population to protect society at large.

So – before you decide to get a flu shot, or any vaccination, for yourself or your child, remember that some vaccines can cause serious health problems, and when it comes to pandemic vaccines like the H1N1 swine flu vaccine, these risks may be magnified due to them being fast-tracked.
Further, in many cases there are far safer ways to protect your children and yourself against disease, and you just might wind up being inherently healthier for it in the future.

HPV – Gardasil – The Killer Vaccine

In Waukesha, Wisconsin, a 12 year old girl (Meredith Prohaska) suddenly died, only hours after receiving the HPV Gardasil vaccine.
This was an enormous shock to the girl’s family, and local media was asking the questions: How could this happen?
Dr. Geoffrey Swain of the local health department was interviewed to give the standard CDC reply, which is similar to almost every other vaccine, stating that severe reactions like this resulting in death are “very rare,” and about “1 out of a million”.
Assuming that there is some data to back up the claim of only “1 out of a million,” how many doses of the HPV vaccine are administered every year? According to statistics (July 2014) published by the U.S. Department of Health and Human Services, over 9 million per year. So the government admits that at least 9 girls per year are killed by the HPV vaccine. How many parents know this prior to taking a doctor’s advice to administer this vaccine that is supposedly a protection against cervical cancer caused by the HPV (human papillomavirus), a sexually transmitted disease?
Since the HPV vaccinations began, LeanMachine believes that almost 200 girls have died (up to around 2017), and thousands more physically maimed for life, with many of those perhaps wishing that they were the ones who have died, their injuries so severe they can never have a normal life, never bear children, never get out of a wheel chair.
After the news announcement that Meredith Prohaska had died from receiving the HPV vaccine, at least one other parent contacted a local news station to report that her 17-year-old daughter also had a serious adverse reaction to the HPV vaccine, requiring urgent care at a local hospital. The local news affiliate asked the question: “So what are the odds another local girl had a similar reaction after getting the shot?”
Here is the report:
The local news media, possibly covering the HPV vaccine for the first time, were all quick to interview and provide links to the official CDC view of the vaccine.
But here are some other facts regarding the vaccine that they failed to disclose, probably because they did not take the time to look outside of the standard government response to events like this, or their station managers did not allow them to give any other news outside of what the CDC claims.

1. There are many more reported side effects than just death from the HPV vaccine. Human papilloma virus vaccine has caused primary ovarian failure. Another problem of the autoimmune/inflammatory syndrome induced by adjuvants.
Australian pediatrician, Dr. Deirdre Little, was the first to sound the alarm over the HPV vaccine causing premature menopause when she observed it in one of her 16 year old patients in 2012. Two sisters from Wisconsin say a cervical cancer vaccine shut down their ovaries and almost certainly left them never able to get pregnant.

The Cochrane Nordic Center reported that the EMA (European Medicines Agency) ignored data showing the severe adverse events associated with the HPV vaccine. Functional disorders were shown to be caused by the vaccine or the adjuvants used in the vaccine.
The EMA’s internal 256-page report contradicts the final 40-page official report. Chochrane said “We find that the EMA’s comments are unprofessional, misleading, inappropriate and pejorative, and that the EMA’s approach involves cherry-picking, which is unscientific.”
The Uppsala centre compared reported adverse events following HPV vaccination with all other vaccines given to women, and found that the HPV vaccine has a FAR greater risk of severe side effects than ANY other vaccine!
And the EMA still claims no conclusions could be drawn from the following official data:

  • POTS reported 82 times for HPV vaccines vs only 1 time for other vaccines
  • CRPS reported 69 times for HPV vaccines vs only 16 times for other vaccines
  • Autonomic nervous system imbalance reported 77 times for HPV vaccines vs 16 times for other vaccines
  • Fibromyalgia reported 62 times for HPV vaccines versus 39 times for other vaccines

Disorders Linked to HPV Vaccine:

  • CFS (Chronic fatigue syndrome)
  • POTS (Postural orthostatic tachycardia syndrome)
  • CRPS (Chronic regional pain syndrome)
  • Premature menopause
  • Infertility
  • Narcolepsy and/or Cataplexy
  • Autoimmune Disorders
  • Guillain–Barré syndrome (GBS)
  • Fibromyalgia
  • Autonomic nervous system issues
  • Stroke
  • Venous thromboembolism (VTE)
  • Appendicitis
  • Seizures
  • Syncope (fainting)
  • Allergic reactions

2. Countries Outside the U.S. Are Halting HPV Vaccines: Lawsuits due to Damages are Mounting.

  • Gardasil Vaccine: Spain Joins Growing List of Countries to File Criminal Complaints
  • Supreme Court in India to Rule on Merck Fraud Regarding HPV Vaccine Deaths
  • Merck’s Former Doctor Predicts that Gardasil will Become the Greatest Medical Scandal of All Time.
  • Japan Halts HPV Vaccine and Begins Full-Scale Probe over Safety Issues.
  • Ten more young women file criminal complaints due to injuries from Gardasil Vaccine in France.
  • Israel Health Ministry considers canceling HPV vaccination due to side effects.

3. We Cannot Sue the Manufacturer of Vaccines in the U.S. because they have total legal immunity!

Most of the U.S. public is unaware that a U.S. citizen, by law, cannot sue a pharmaceutical company for damages resulting from vaccines. Congress gave them total legal immunity in 1986, and that law was upheld by the U.S. Supreme Court in 2011. There is a special “vaccine court” called the National Vaccine Injury Compensation Program that is funded through a tax on vaccines. If you are injured or killed by a vaccine, you must hire an attorney and fight tax-funded government attorneys to seek damages, as you cannot sue the drug manufacturers. It can take 10 years or longer to win your case and be compensated. The U.S. Department of Health and Human Services usually publishes a report every couple of months on settlements on their website.
So from 1986, the vaccine manufacturers saw an enormous money-pit, where they started inventing new vaccines for every disease imaginable, and why not? They did not have to advertise to get sales, they just had their puppets and shareholders at the CDC and Government mandate the vaccinations as compulsory.
They could not get sued, so it did not matter if the vaccine did not work, or if it killed or maimed people. They got away scot-free to continue doing it to this day.

4. The U.S. Government Earns Royalties from the sale of the Gardasil HPV Vaccine.
Dr. Eric Suba tried to use the Freedom of Information Act to find out how much money the National Institute of Health (NIH) earned from the sale of Gardasil, but they refused to report the amount of revenue the government earns from this vaccine (although not denying they do earn royalties).

5. Conflict of Interest.
Julie Gerberding was in charge of the CDC (Center for Disease Control) from 2002 to 2009, which includes the years the FDA approved Gardasil as a vaccine. Soon after she took over the CDC, she reportedly completely overhauled the agency’s organizational structure. Many of the CDC’s senior scientists and leaders either left or announced plans to leave. Some have claimed that almost all of the replacements Julie Gerberding appointed had ties to the vaccine industry. Gerberding resigned from the CDC on January 20, 2009, and is now the president of Merck’s Vaccine division, a 5 billion dollar a year operation, and the supplier of the largest number of vaccines the CDC recommends.

6. Black women who are vaccinated with Gardasil are vaccinated against the wrong strains.
Scientists at the Duke University School of Medicine discovered that African American women carry HPV strains not found in the Gardasil vaccine. Moshella Roberts, a 20-year-old African American woman died needlessly from the HPV vaccine.

Although some local news affiliates report deaths and injuries from the Gardasil vaccine, they do not research or present all of the facts, they simply copy what the CDC says. Many fear to raise the issue of the “Gardasil controversy” because it may jeopardize their journalistic careers, and can be forced to apologise for even suggesting the HPV vaccine is not totally safe.

So – conduct your own research before making any decisions on any vaccine, especially the HPV (Gardasil) vaccine!

Vaccine Reaction Symptoms

Symptoms may include any or many of the following, but often viewed by doctors as unrelated to the vaccine:

  • Pronounced swelling, redness, heat or hardness at the injection site
  • Body rash or hives
  • Shock
  • Collapse
  • High pitched screaming or persistent crying for hours
  • Extreme sleepiness or long periods of unresponsiveness
  • Twitching or jerking of the body, arm, leg or head
  • Crossing of eyes
  • Weakness or paralysis of any part of the body
  • Loss of ability to roll over, sit up or stand up
  • Loss of eye contact or awareness, or social withdrawal
  • Head banging or onset of repetitive movements (flapping, rubbing, rocking, spinning)
  • High fever (over 39.5 degrees C or 103 degrees F)
  • Vision or hearing loss
  • Restlessness, hyperactivity or inability to concentrate
  • Sleep disturbances that change wake/sleep pattern
  • Joint pain or muscle weakness
  • Disabling fatigue
  • Loss of memory
  • Chronic ear infections
  • Respiratory infections
  • Violent or persistent diarrhea or chronic constipation
  • Breathing problems (asthma)
  • Excessive bleeding (thrombocytopenia) or anemia

There can be many other symptoms that may indicate that you or your child has suffered a vaccine reaction.
Not all symptoms following vaccination are caused by the vaccine received, but it cannot be automatically concluded that symptoms are NOT related to the vaccine. Unfortunately, adverse reactions to vaccines are under-reported, often because mild symptoms can be vague, and many doctors would rather blame a virus rather than admit their action caused the problem. Some say only 10% are reported, while others say less than 1% are reported. It is very important that the doctor records all health problems occuring after vaccination in the patient’s permanent medical record, also to report any symptoms to the TGA in Australia, or VAERS in the USA. Any re-vaccination MUST be postponed until the issue developed after vaccination has been investigated and found absolutely unrelated to the vaccination.
Continued vaccination after serious health problems may lead to injury or death.

How to Reduce Risk of Disease Without a Vaccine

The best defense against any disease is a strong immune system, but vaccines can compromise immunity rather than build immunity.
Building the immune system naturally is essential for resistance to disease.
Research proves that vitamin D is essential for optimal health, but Australia’s 30-year “Slip, Slop, Slap” campaign to keep everyone out of the sun has been the biggest disaster of all time, causing countless deaths from cancer and other diseases, all because of sub-optimal Vitamin D.
For more info, read my article vitamin D
Our immune system determines whether we get sick or not when we are exposed to any infectious disease. The main keys to immunity are:

  • Healthy food
  • Stress free living
  • Good sleep
  • Regular exercise
  • Sunlight and Vitamin D

For more information, the National Vaccine Information Center (NVIC) is a great resource, with objective and unbiased information.
Everyone has the right to the ability to make intelligent, informed decisions about which vaccines you may want for ourselves and our families.

The LeanMachine Experience

LeanMachine always had several bouts of cold and flu every year until the age of 63. Then came a complete change of lifestyle: Sugar, processed foods, dairy, fluoride and other toxins were removed from the diet. Supplements of minerals and vitamins (especially Vitamin D3) were added to the diet. Since then, 8 years down the track at age 71: Zero colds, flu, not even a headache, allergies disappeared, more energy, obese build now lean.
No vaccinations of any kind. Same goes for Mrs LeanMachine, no colds or flu and no vaccinations, yet we have both been heavily exposed to all diseases at shopping centres, meetings, etc where everyone around us is coughing, spluttering, sneezing.

LeanMachine online shop

Disclaimer

LeanMachine is not a doctor, and everyone should consult with their own health professional before taking any product to ensure there is no conflict with existing prescription medication.
LeanMachine has been studying nutrition and health since 2011 and has completed many relevant studies including:
Open2Study, Australia – Food, Nutrition and Your Health
RMIT University, Australia – Foundations of Psychology
Swinburne University of Technology, Australia – Chemistry – Building Blocks of the World
University of Washington, USA – Energy, Diet and Weight
Johns Hopkins Bloomberg School of Public Health, USA – Health Issues for Aging Populations
Johns Hopkins Bloomberg School of Public Health, USA – International Nutrition
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics I
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics II
Johns Hopkins Bloomberg School of Public Health, USA – Principles of Human Nutrition
TUFTS University, USA – Nutrition and Medicine
TUFTS University, USA – Lipids/Cardiovascular Disease I and Lipids/Cardiovascular Disease II
Technical Learning College, USA – Western Herbology, Identification, Formulas
Bath University, England – Inside Cancer
WebMD Education – The Link Between Stroke and Atrial Fibrillation
WebMD Education – High Potassium: Causes and Reasons to Treat
Leiden University Medical Center, Netherlands – Anatomy of the Abdomen and Pelvis
MIT (Massachusetts Institute of Technology) – A Clinical Approach to the Human Brain
LeanMachine has now examined thousands of studies, journals and reports related to health and nutrition and this research is ongoing.

Posted 13th August 2018, updated 3rd November 2019, Copyright © 1999-2019 Brenton Wight and BJ & HJ Wight trading as Lean Machine abn 55293601285

Echinacea Benefits

Written by Brenton Wight – LeanMachine, 11th November 2019
© 2019 – This article is copyrighted by Brenton Wight and BJ & HJ Wight trading as Lean Machine

What is Echinacea?

Echinacea is a flowering plant in the daisy family, also known as purple coneflower.
There are nine species, however only three are normally used as supplements:

  • Echinacea purpurea
  • Echinacea angustifolia
  • Echinacea pallida

Most commonly used as an over-the-counter remedy to build immunity for colds, allergies and flu, but also  used for inflammation, pain, migraines and blood glucose.

Native to North America but cultivated almost anywhere.
Upper parts and roots are typically used in tablets, tinctures, extracts and teas.
Beneficial Compounds in Echinacea include:

  • Caffeic acid
  • Alkamides
  • Phenolic acid
  • Rosmarinic acid
  • Polyacetylenes

Suggested health benefits include:

  • Antioxidants, including flavonoids, cichoric acid and rosmarinic acid
  • Alkamides that enhance antioxidant activity
  • Immunity to infections and viruses. In studies, Echinacea lowered risk of colds by 50% and  duration by one and a half days
  • Helps blood glucose control by suppression of carbohydrate-digesting enzymes, also increased insulin sensitivity, and helps stop glucose levels plummeting in hypoglycemia
  • Shown to help lower blood pressure, probably by helping to control blood glucose
  • Reduced anxiety due to action of alkamides, rosmarinic acid and caffeic acid
  • Anti-inflammatory, via compounds that reduce inflammatory markers
  • Reduced pain, especially in those who received no benefit from standard pain relief drugs
  • Reduced swelling
  • Improved skin hydration and reduced wrinkles with Echinacea cream
  • Acne (caused by Propionibacterium) suppressed with Echinacea cream
  • Eczema symptoms reduced by Echinacea cream
  • Shown to suppress cancer cell growth and trigger cancer cell death (Apoptosis), a benefit of  the chicoric acid component
  • Shown to increase apoptosis in pancreas and colon cancer cells

Issues with cream products: Echinacea extract is difficult to incorporate into commercial skin care products due to short shelf life.

Side Effects

Echinacea has been shown safe and tolerated well for short-term use, but long-term studies have not been carried out. Rare side effects (mainly in those with allergies to daisies, chrysanthemums, marigolds, ragweed) include:

  • Stomach pain, nausea
  • Shortness of breath
  • Rashes, hives, itchy skin
  • Swelling

Those trying Echinacea for the first time should start with a tiny dose to test for any reaction.

Who should NOT consume Echinacea

Because Echinacea stimulates the immune system, those with any autoimmune disorder, or those taking immunosuppressive drugs (such as those for transplant rejection) should avoid taking Echinacea.

Dosage

No official dosage exists, partly because studies have varied in quantity and quality of the product used, and products sometimes do not contain the amount and/or strength specified, so it is wise to purchase products from trusted brands such as those recommended by LeanMachine in this article.

Studies in the immunity properties of Echinacea suggest the following doses:

Summary

Echinacea has a long and successful history of use in many countries, with rare allergy side-effects, and may help with immunity, allergies, anxiety, skin, cancer, blood pressure, pain, swelling and more.

There are many studies on Echinacea, but results are mixed, with some showing benefits and others showing none. Most studies were mouse studies, test tube studies, petri dish studies, etc and all were of short duration. However, LeanMachine suggests that the antioxidant benefits alone are worthwhile, and long-term studies are expected to show better health outcomes for seniors because their cardiovascular system should be in better shape, and their cancer risk should be lower.

Children

Generally safe for children over age 2 to take Echinacea supplements and drink Echinacea teas, and studies show benefits to children taking Echinacea.

Pregnancy

Study:
www.webmd.com/baby/news/20001128/study-shows-echinacea-safe-during-pregnancy
This study shows Echinachea is safe, but because the study involved only about 200 women, safety cannot be guaranteed absolutely.

Drug Interactions

Risk of drug interactions is relatively low, but some medications are affected by Echinacea.
Some interactions can be a life-or-death situation, so always inform the doctor if taking any herbal products, supplements, vitamins, minerals etc.

6 Bodily Tissues That can be Regenerated Through Nutrition

© 20th September 2019 GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here www.greenmedinfo.com/greenmed/newsletter
Reproduced from original article:
www.greenmedinfo.com/blog/6-bodily-tissues-can-be-regenerated-through-nutrition

6 Bodily Tissues That Can Be Regenerated Through Nutrition

It may come as a surprise to some, especially those with conventional medical training, but the default state of the body is one of ceaseless regeneration. Without the flame-like process of continual cell turnover within the body – life and death ceaselessly intertwined – the miracle of the human body would not exist

In times of illness, however, regenerative processes are overcome by degenerative ones. This is where medicine may perform its most noble feat, nudging the body back into balance with foods, herbs, nutrients, healing energies, i.e. healing intention. Today, however, drug-based medicine invariably uses chemicals that have not one iota of regenerative potential; to the contrary, they almost always interfere with bodily self-renewal in order to suppress the symptoms against which they are applied.

Despite the outright heretical nature of things which stimulate healing and regeneration vis-à-vis the conventional medical system which frowns upon, or is incredulous towards, spontaneous remission in favor of symptom suppression and disease management, over the course of the past few years of trolling MEDLINE we have collected a series of remarkable studies on the topic…

nerve cell regeneration

Nerve Regeneration – There are actually a broad range of natural compounds with proven nerve-regenerative effects. A 2010 study published in the journal Rejuvenation Research, for instance, found a combination of blueberry, green tea and carnosine have neuritogenic (i.e. promoting neuronal regeneration) and stem-cell regenerative effects in an animal model of neurodegenerative disease.[1] Other researched neuritogenic substances include:

  1. Curcumin
  2. Lion’s Mane Mushroom
  3. Apigenin (compound in vegetables like celery)
  4. Blueberry
  5. Ginseng
  6. Huperzine
  7. Natto
  8. Red Sage
  9. Resveratrol
  10. Royal Jelly
  11. Theanine
  12. Ashwaganda
  13. Coffee (trigonelline)

There is another class of nerve-healing substances, known as remyelinating compounds, which stimulate the repair of the protective sheath around the axon of the neurons known as myelin, and which is often damaged in neurological injury and/or dysfunction, especially autoimmune and vaccine-induced demyelination disorders. It should also be noted that even music and falling in love have been studied for possibly stimulating neurogenesis, regeneration and/or repair of neurons, indicating that regenerative medicine does not necessary require the ingestion of anything; rather, a wide range of therapeutic actions may be employed to improve health and well-being, as well.

[View the first-hand biomedical citations on these neuritogenic substance visit our Neuritogenic Research page on the topic]

Liver Regeneration – Glycyrrhizin, a compound found within licorice, and which we recently featured as a powerful anti-SARS virus agent, has also been found to stimulate the regeneration of liver mass and function in the animal model of hepatectomy. Other liver regenerative substances include:

  1. Carvacrol (a volatile compound in oregano)
  2. Curcumin
  3. Korean Ginseng
  4. Rooibos
  5. Vitamin E

[view the first-hand biomedical citations on the Liver Regeneration research page]

Beta-Cell Regeneration – Unfortunately, the medical community has yet to harness the diabetes-reversing potential of natural compounds. Whereas expensive stem cell therapies, islet cell transplants, and an array of synthetic drugs in the developmental pipeline are the focus of billions of dollars of research, annually, our kitchen cupboards and backyards may already contain the long sought-after cure for type 1 diabetes. The following compounds have been demonstrated experimentally to regenerate the insulin-producing beta cells, which are destroyed in insulin dependent diabetes, and which once restored, may (at least in theory) restore the health of the patient to the point where they no longer require insulin replacement.

  1. Gymenna Sylvestre (“the sugar destroyer”)
  2. Nigella Sativa (“black cumin”)
  3. Vitamin D
  4. Curcumin (from the spice Turmeric)
  5. Arginine
  6. Avocado
  7. Berberine (found in bitter herbs such as Goldenseal and Barberry)
  8. Bitter Melon
  9. Chard (yes, the green leafy vegetables)
  10. Corn Silk
  11. Stevia
  12. Sulforaphane (especially concentrated in broccoli sprouts)

[view the first-hand biomedical citations on the Beta Cell Regeneration research page]

Hormone Regeneration – there are secretagogues, which increase the endocrine glands’ ability to secrete more hormone, and there are substances that truly regenerate hormones which have degraded (by emitting electrons) into potentially carcinogenic “transient hormone” metabolites. One of these substances is vitamin C. A powerful electron donor, this vitamin has the ability to contribute electrons to resurrect the form and function of estradiol (estrogen; E2), progesterone, testosterone, for instance. [2] In tandem with foods that are able to support the function of glands, such as the ovaries, vitamin C may represent an excellent complement or alternative to hormone replacement therapy.

Cardiac Cell Regeneration – Not too long ago, it was believed that cardiac tissue was uniquely incapable of being regenerated. A new, but rapidly growing body of experimental research now indicates that this is simply not true, and there is a class of heart-tissue regenerating compounds known as neocardiogenic substances. Neocardiogenic substances are able to stimulate the formation of cardiac progenitor cells which can differentiate into healthy heart tissue, and they include the following:

  1. Resveratrol
  2. Siberian Ginseng (Eleuthero)
  3. Red Wine Extract
  4. Geum Japonicum
  5. N-acetyl-cysteine

Another remarkable example of cardiac cell regeneration is through what is known as fetomaternal trafficking of stem cells through the placenta. In a recent article we discussed the amazing process known as “fetal microchimerism” by which the fetus contributes stem cells to the mother which are capable of regenerating her damaged heart cells, and possibly a wide range of other cell types.

Cartilage/Joint/Spine Regeneration – Curcumin and resveratrol have been shown to improve recovery from spinal cord injury. Over a dozen other natural compounds hold promise in this area, which can be viewed on our Spinal Cord Injury page. As far as degenerative joint disease, i.e. osteoarthritis, there are a broad range of potentially regenerative substances, with 50 listed on our osteoarthritis research page.

Ultimately, regenerative medicine threatens to undermine the very economic infrastructure that props up the modern, drug-based and quite candidly degenerative medical system. Symptom suppression is profitable because it guarantees both the perpetuation of the original underlying disease, and the generation of an ever-expanding array of additional, treatment-induced symptoms.

This is the non-sustainable, infinite growth model which shares features characteristic of the process of cancer itself – a model, which by its very nature, is doomed to fail and eventually collapse. Cultivating diets, lifestyles and attitudes conducive to bodily regeneration can interrupt this pathological circuit, and help us to attain the bodily freedom that is a precondition for the liberation of the human soul and spirit, as well.

Additional related articles: 


Additional References

[1] NT-020, a natural therapeutic approach to optimize spatial memory performance and increase neural progenitor cell proliferation and decrease inflammation in the aged rat. Rejuvenation Res. 2010 Jun 29. Epub 2010 Jun 29. PMID: 20586644

[2] Photo-induced regeneration of hormones by electron transfer processes: Potential biological and medical consequences. Radiat Phys Chem Oxf Engl 1993. Updated 2011 Aug ;80(8):890-894. PMID: 21814301

Article originally published 2012

Article updated: 10-01-29

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

Autism Spectrum Disorder

Written by Brenton Wight – LeanMachine, Health Researcher

Copyright © 1999-2020 Brenton Wight

Updated 4th April 2020

General History and Prevalence of Autism

Doctors say they do not know what causes autism, and there is no cure, and have no idea why autism rates are sky-rocketing.
30 years ago, autistic children in the USA were just 1 in every 100,000.
In 2008 the rate was 1 in 88, and in 2013 the rate was 1 in 50 and getting worse.
Autism increased 5-fold in the 1990’s in both the UK and the USA, and increased by 78% between 2002 and 2008 in the USA while leveling off to some extent in the UK since 2004.
These figures come from CDC (Centers for Disease Control and Prevention) statistics, and are for the USA population.
Boys are around 5 times more likely than girls to suffer with autism, for “reasons unknown” according to doctors, but obviously the difference in testosterone/estrogen balance must be the main suspect.
If we add in the cases of ADD, ADHD, hyperactivity and other “brain impairment” conditions, the chances of having a child with some form of mental disability is 1 in 10!
If this increases at the same rate, by 2030 one in two babies born will get autism or some related mental condition!
I have to admit that decades ago, many of these children were simply diagnosed as “naughty” and were never diagnosed as autistic unless the cases were extreme.
However, many cases today are still not diagnosed, and lack of diagnosis can not account for the enormous rise in cases.
Of course, some children diagnosed as autistic are successful people with exceptional abilities that we “normal” individuals do not posses.
Others may be so badly behaved that it is difficult to live in today’s society, unable to communicate, dress themselves or function positively in modern society.
Asperger Syndrome was at first thought to be a mild form of autism, but has now been shown to be a different condition, even though there are similarities. In Asperger’s, speech and intelligence are fairly normal, while other symptoms are close to those in Autism.
SCD – Social Communication Disorder is yet another separately diagnosed condition, where  pragmatic communication is an issue (difficulties using verbal and non-verbal communication appropriately in social situations).

Diagnosis

There is no simple medical test that can give an official diagnosis of Autism.
Autism is diagnosed by the doctor looking at specific behavioral patterns.
Parents are often the first to notice something is wrong when they notice these signs:

  • Failing to make eye contact
  • Not responding to his/her name
  • Playing with toys in unusual, repetitive ways
  • No smiles or joyful expressions by 6 months of age
  • No back-and-forth sharing of sounds, smiles, facial expressions by 9 months
  • No babbling sounds by 12 months
  • No back-and-forth gestures such as pointing, showing, reaching or waving by 12 months
  • No words by 16 months
  • No meaningful, two-word phrases (not including imitating or repeating) by 24 months
  • Loss of speech, babbling or social skills at any age

New technologies such as neuroimaging are starting to shed some light on the cause of these disorders.
Brains of autistic people process information in a different way, but many “normal” people are also different.

  • Visual thinkers excel at visualizing objects, but are poor at algebra
  • Pattern thinkers excel at music and maths, but may be poor at reading
  • Those with excellent verbal language skills may be poor at drawing pictures
  • Auditory thinkers have fragmented visual perception

SPECT imaging has the ability to identify toxin damage in the brain, and can be important in the diagnosis of various neurological disorders. This imaging technique indicates that many cases of depression or anxiety may be symptoms of brain dysfunction, often the result of exposure to toxins. Other factors include diets lacking nutrition and lack of exercise.

What causes Autism?

There are many possible factors that increase the risk of autism.
Gut flora is paramount for the immune system. The gastrointestinal system, often referred to as our “second brain,” contains 100 million neurons.
This is more than the spinal cord or the peripheral nervous system. The gut, brain and immune system relation is complex but each part depends on the other.
As research shows most autism patients are low in vitamin D3, have damaged gut flora, and have a compromised immune system, it follows that lack of immunity may increase the risk substantially.

Vaccinations are a factor in the development of autism.
Many cases are diagnosed after a vaccination, but there is no explanation of why some children are affected and some are not.
The riskiest vaccinations appear to be those with additives such as thimerosal (mercury), aluminium, and others, proven to be toxic to mitochondria (the powerhouse in every body cell we need for energy).
See more under the heading Vaccinations.

The Panadol, Paracetamol, Tylenol, Acetaminophin, NyQuil, Percoset, Vicodin Connection

Acetaminophen, known as Panadol or Paracetamol in Australia, and Tylenol in the USA, has been marketed for decades as “safe and effective” for pain and fever.
Nothing could be further from the truth. In Australia, Panadol advertising has been changed to “Effective” and the “Safe” word has been omitted. However, decades of “Safe and Effective” have left the “Safe” imprint on the minds of many.
Other medications such as NyQuil, Percocet, and Vicodin all contain Acetominophen.
In 1978 a study was published linking aspirin to Reyes syndrome, although studies since then have found no link. Since 1978, Acetaminophen (Panadol, Paracetamol) has usually been given with vaccinations to prevent fever and pain. 1978 is also when autism cases started a serious trend upward.
A Californian study shows that autism rates elevated alarmingly when Acetaminophen was given to children instead of aspirin. Doctor William Shaw, Director of Great Plains Laboratories, looked at Cuban autism rates, finding that only 1 case in 50,000 had autism, compared to USA rates of 1 in 50, or 1000 times the rate in Cuba.
The vaccination rate for Cuba is 99% of all children, even more than the USA.
However, there are two important differences:

  1. In Cuba, Acetaminophen is a prescription-only medication, and is never given with vaccinations. Cuban doctors rightly believe that fever is a normal side effect of vaccinations, proving that the immune system is correctly responding to the vaccination. They only give medication if fever is very high or lasts too long. An elevated temperature is the way the body helps identify, destroy and eliminate foreign substances from the body, so why prevent this from happening?
  2. In Cuba, vaccinations are manufactured within Cuba itself, and one must question the ingredients used in the USA and other countries.

This difference in autism rates by a factor of 1000 to one, allowed Dr Shaw to conclude that it was not necessarily the vaccinations, but the Acetaminophen (Paracetamol), or a combination of both, causing autism in the USA and other countries like Australia that use the same products. When Dr. Shaw investigated further, he found that as Acetaminophen breaks down, several toxic metabolites are produced. The enzyme called Cytochrome p450 2E1 breaks down Acetaminophen into a very toxic metabolite called NAPQI, which attacks glutathione, the body’s predominant natural way of preventing almost every disease.
Glutathione is central to the immune system, and after the vaccination, the immune system is meant to build antibodies, but without Glutathione the immune system is severely compromised.
No wonder so many autistic children have a poor immune system, and more allergies and intestinal problems.

Further evidence comes from many children who were given Acetominophen about 5 days before the jab, and started autistic regression even before the vaccination.
Acetaminophen reduces pain by engaging cannabinoid receptors in the brain, the same receptors affected by marijuana use, producing the analgesic effect. However, this analgesic effect comes from the breakdown of Acetaminophen, and some children eliminate Acetaminophen better or worse compared to others, leading to an unintentional overdose in many children, which not only clobbers the immune system, but also impairs brain development. The particular parts of the brain affected are the neural networks which process social and emotional information and the networks that modulate inhibition. Sometimes speech is also affected. All of these brain problems relate to the typical symptoms of autistic children.

The Dosage Difference

Infants are often given Tylenol liquid in doses high enough for toxic reactions and liver damage when doses are repeated over a few days.
Liver damage from Acetaminophen is so common that about 9 out of every 10 patients on the liver transplant waiting list are there because of an overdose of Paracetamol / Panadol / Acetaminophen.
In the USA, the standard dose is 325mg per tablet with 10 tablets maximum in 24 hours (3250 mg daily), and the extra-strong versions are 500mg and up to 6 tablets (3000mg daily).
But in Australia, our regular Paracetamol / Panadol is 500mg and 8 tablets (4000mg daily) is fine, and the extra-strength versions such as Panadol Osteo is 665mg and 6 tablets (3990mg daily), many of our fine “doctors” say that 8 of these a day is OK (total dose 5320mg per day).
The USA and UK reduced dosages in 2011, but in 2013 the Australian TGA (Therapeutic Goods Administration) made a statement:
“The TGA has considered these changes and recommends that there should be no change to recommended paracetamol dosing regimens in Australia.”

It is easy to see why liver damage is so prevalent in Australia.
Yes, there are warnings on the packet about liver damage, but there is no “black box” warning where the warning is very clear: Black text on a white background with a black rectangle surrounding the warning. Typical warnings are in a thin font with low-contrast lettering, making it difficult or impossible to read for many people with poor vision.
If a person is suffering from severe pain, will they take notice of a daily limit warning? I think rarely, as they will usually assume there is a margin of safety, but with Acetaminophen / Paracetamol there is NO margin, especially in Australia where even the recommended dose for Paracetamol damages the liver and affects the brain and immunity, especially those of children.
Will the drug companies spend millions of dollars on a study to see if one of their biggest money-makers causes thousands of young and old lives to be ruined? I am not holding my breath.

Other Toxins

Microbial toxins, such as mould (from the environment or food) may also play a part.
GE (genetically engineered) food, chemicals, additives, antibiotics, sugar, inadequate nutrition and food processing methods all contribute to destruction of gut flora which is essential for immunity, brain function and development of a growing child.
Vitamin D3 deficiency has a proven link with autism. Mothers who have low vitamin D3 during pregnancy have a higher risk of having an autistic child (as well as a greater risk for Type 1 Diabetes in the child).
Vitamin D3 receptors are present in brain tissue early in the fetal development, and once activated with vitamin D3, allows normal nerve and brain development.
Vitamin D3 is also essential for the detoxification of mercury, so low vitamin D3 combined with a shot of extra mercury from a vaccination may just trigger autism.
Electromagnetic radiation from microwave ovens, cell phones, cell towers, Wi-Fi, satellites, ham radio, commercial two-way radio, emergency services radio and other sources are believed to trap mercury and other heavy metals inside nerve cells, causing toxic damage, especially when there is not enough vitamin D3.

GAPS (Gut and Psychology Syndrome)

Children learn by using sight, sound, taste, smell, touch, etc to collect environmental information which is then processed in the brain.
In children with GAPS (a term coined by Dr. Campbell-McBride), gut toxicity clogs the brain with toxicity, preventing normal processing of sensory information.
Children born with damaged gut flora have a higher risk of vaccine damage.
This may indicate why some children develop autism after receiving one or more childhood vaccinations while others do not.
Other children at risk from vaccinations are siblings of children with autism, severe hyperactivity, obsessive compulsive disorder, mental conditions, and type 1 diabetes.
The MMR vaccine does not contain thimerosal or aluminum but the measles virus in the vaccine may contribute to chronic bowel inflammation, causing harm to the brain.
Apart from autism, GAPS may cause a range of symptoms that can be diagnosed as autism, ADHD, ADD, dyslexia, dyspraxia, OCD (obsessive-compulsive disorder) or many other conditions.
GAPS can also cause digestive issues, asthma, allergies, skin problems, candida (yeast infections), autoimmune disorders, psychological or physiological issues.
Gut flora acquired during vaginal birth is dependent on the mother’s gut flora, so any pregnant woman should maintain gut health before, during and after pregnancy. Children born by Ceasarian have much poorer gut bateria than those born viganally. Sometimes Ceasarians cannot be avoided, but some women have a Ceasarian simply because they want the baby’s birthday to coincide with Grandma’s!
GAPS can be diagnosed within the first weeks of a baby’s life by analysing the stool for gut flora, then a urine test for metabolites to indicate the state of the immune system.
Dr. Campbell-McBride has a book explaining GAPS and the tests available.
Gut and Psychology Syndrome. Dr. Campbell’s website: www.GAPS.me, and blog: www.doctor-natasha.com.
There is an excellent article on the GAPS diet with some great recipes at Jen Reviews

Insecticides

In areas where annual aerial spraying of pyrethroids (larvicide that kills mosquitoes) is carried out, children have a 25 percent higher risk of autism or developmental problem, compared to children living in areas without aerial spraying.
Pregnant women exposed to pyrethroids in the third trimester are more likely to give birth to autistic children. Animal studies show damage to neurological, immune, and reproductive systems. Some pyrethroids disrupt the endocrine system by mimicking estrogen, possibly increasing risk of estrogen-sensitive cancers like breast, ovarian and prostate cancers.
Apart from aerial spraying, thousands of domestic insecticides like roach sprays, flea bombs, and dog flea or tick collars and medicated shampoos contain pyrethrins. Bifenthrin, permethrin and cypermethrin, are all pyrethroids.

Preventing Autism

Paracetamol – Never give children Paracetamol, Panadol, Acetaminophen, Tylenol, etc, especially for fever-related conditions, especially vaccine reactions.
A mild fever is the body’s way of dealing with an infection (or vaccination). One exception: If the fever is too high (over 39.4° to 40°C, or 103° to 104°F), there is a risk for seizures in young children. Most healthy children and adults can tolerate temperatures up to this level without problems.
The best way to lower a high fever to a safe level below 39.4°C (103°F) is to sit the child in a bath of cool water (not cold) and sponge the water over the body. Do drugs required, no side effects, and more effective than any drug.

Vaccinations

Research every vaccination properly, and do not be intimidated by threats of no job, no school, no child care, etc if your child remains un-vaccinated.
It is not only every parent’s right, but also their responsibility to ensure the best health outcomes for their child.
Vaccinations are technically illegal in Australia, a signatory to the Nuremberg Code, which states:

  1. Required is the voluntary, well-informed, understanding consent of the human subject in a full legal capacity. LM: Children cannot comply, as only adults have legal capacity
  2. The experiment should aim at positive results for society that cannot be procured in some other way. LM: Building immunity with vitamins and minerals means no need for vaccinations
  3. It should be based on previous knowledge (e.g., an expectation derived from animal experiments) that justifies the experiment. LM: Vaccinations have limited or no studies to prove effectiveness
  4. The experiment should be set up in a way that avoids unnecessary physical and mental suffering and injuries. LM: Vaccinations contain Mercury, Aluminium, Polysorbate 80 and other chemicals proven to damage humans
  5. It should not be conducted when there is any reason to believe that it implies a risk of death or disabling injury. LM: All vaccinations increase risk of death or injury
  6. The risks of the experiment should be in proportion to (that is, not exceed) the expected humanitarian benefits. LM: Independent Studies show that vaccinations increase risk of Alzeimer’s Disease, Allergies, Diabetes etc which can show up decades after the vaccination
  7. Preparations and facilities must be provided that adequately protect the subjects against the experiment’s risks. LM: No long-term studies exist
  8. The staff who conduct or take part in the experiment must be fully trained and scientifically qualified. LM: Generally Nurses, Lab assistants, Chemists or trainees conduct experiments and vaccinations, seldom doctors
  9. The human subjects must be free to immediately quit the experiment at any point when they feel physically or mentally unable to go on. LM: Vaccine laws are eroding the right to refuse
  10. Likewise, the medical staff must stop the experiment at any point when they observe that continuation would be dangerous. LM: The law is increasingly limiting the right to stop

Of course, ALL vaccinations are in violation of this code.
There has been no vaccination produced in decades where a double-blind, placebo-controlled study has been carried out scientifically to prove the benefit and seek possible side-effects.
Governments who legislate the refusal of a vaccination to mean no job, no unemployment benefit, no school, no child care, are in direct violation of the Nuremberg code.
Read more in my Vaccinations article.
LeanMachine does not claim that every vaccination is bad, however we should avoid multiple vaccinations at any one time, and we should ask for a data sheet listing all ingredients and possible side-effects.
If ingredients include any mercury or aluminium, we should ask for a vaccine without those ingredients.
Vaccines exist with less harmful ingredients and may cost more, but compared to a child’s death or life-long affliction – what price do we place on that?
Ask for large, double-blind, independent studies, not carried out by any drug company, proving that the product has never resulted in sickness or death. They will not be able to give you one.
Ask for a written guarantee that your child will not suffer any serious illness or death after the vaccination, and will compensate you if this happens. No one will ever sign this.
Whistleblowers in the CDC (Centre for Disease Control) admitted that the CDC knew for decades that vaccinations were causing autism, but did nothing. Most of the victims were African-American boys, and over 100,000 ended up with Autism which could have been prevented. Doctors cannot explain why African American boys were affected the most, but LeanMachine proposes that due to the darker skin colour, they have reduced Vitamin D3 levels, a well-known factor in reduced immunity and Autism risk.

Aluminium in Vaccines

Health professionals and parents alike have rallied against the addition of aluminum as an adjuvant (delivery mechanism) in vaccines for many years. The so-called “safe amount” of aluminum exposure for adult humans is 25 mcg, and just 10 mcg for infants.
In the USA, children on the recommended vaccine schedule, receive close to 5,000 mcg of Aluminium before age 2, which is nearly 500 times the safe level of aluminum for an infant.
University of British Columbia researchers published findings in 2013 showing a direct correlation between autism and pediatric vaccines containing an aluminium adjuvant. Many infants receiving vaccines have severe autoimmune and inflammatory reactions, including Autism.

The Hepatitis B Vaccine

The HepB (hepatitis B) vaccine alone, injected into babies only one day old with a still-underdeveloped immune system, gives babies about 250 mcg of aluminium, the beginning of a horrendous vaccine schedule that infants receive in the first few years of life.
This is supposed to prevent Hep B infections due to illicit drug use or sexual behavior with multiple partners. Who in their right mind would allow this in a newborn a few hours old with a still-underdeveloped immune system? The only time this may be considered is if the mother is a drug addict, and may pass a Hep-B infection to the baby. Otherwise, I know of no reason to vaccinate a one-day old baby for a disease they may only acquire from being sexually active or use illegal drugs. LeanMachine recommends that this is prevented, and your instructions must be made clear in writing before the birth, as it often happens without the mother’s knowledge or consent.
For other vaccinations, LeanMachine recommends zero vaccinations until the child is at least 4 years old. This dramatically reduces the risk of Autism to near zero. If a child reaches the age of four without signs of Autism, they are extremely unlikely to get it later.

Vitamin D3

In Australia, we have a multi-million dollar advertising campaign “Slip, Slop, Slap”.
Slipping on long sleeved clothing, Slopping on sunscreen, and Slapping on a hat. Later extended to Seek shade or shelter, Slide on some sun glasses.
This advertising campaign running for three decades, has resulted in a small reduction of less harmful skin cancers, such as Basal Cell Carcinoma and Squamous Cell Carcinoma, which have only about 1% chance of becoming something more serious, but increased the potentially deadly melanoma form of skin cancer.

From the Slip Slop Slap advertising, one would expect that outdoor workers would be far more likely to get melanomas than office workers, but the reverse is true, obviously because office workers invariably receive too little sunlight, so too little Vitamin D3.
Many people get melanomas where there has never been sun damage, such as the soles of feet or under armpits, again disproving that the sun is the enemy.
In the same time, average Vitamin D3 levels for Australians has dropped significantly due to lack of exposure to sunlight.
School children are forced to wear hats, all playgrounds are covered, parents smother them in sunscreen at the beach or sporting events, and now our children have the lowest Vitamin D3 levels since time began.
No wonder “modern” conditions like autism, Asperger’s, ADD, ADHD, Cancers, Diabetes 1 and 2, Alzheimer’s, Heart attacks, Strokes, Obesity etc have all become epidemic diseases, where a hundred years ago they almost never existed.
Mothers should get 1000 IU daily of Vitamin D3 (not D2), and 2000 IU daily if pregnant, and 5000 IU daily for anyone over 45 unless they get significant sunlight 2 or 3 times a week, on a day with a clear blue sky.
Sunlight on a cloudy day or through a glass window is damaging, as only the harmful UVA radiation hits the skin, blocking all UVB, preventing Vitamin D3 formation.
After birth, children should also take a D3 supplement as soon as they stop drinking milk of any sort.
Note that cow’s milk does contain vitamin D3, but it is poorly absorbed in the human gut after the age of two.
Baby formula is often fortified with vitamin D, but usually an artificial D2, not D3, which does not do the same job, and blocks the real D3 from sun and food from getting in.
I would suggest that in addition to supplementation of vitamin D3, an extra dose of 1000 IU daily for 2 weeks before any vaccination may be advisable.
Increased supplementation is also advisable in winter months, especially in cooler latitudes, as healthy UVB radiation is unavailable when the sun is at low altitudes or on cloudy days.
Note also that vitamin D3 from sunlight has several stages:
7-dehydrocholesterol is made in the liver from cholesterol and migrates to the skin to be altered by UVB to become pre-vitamin D, then carried back to the liver to be mediated by 25-hydroxylase to become 25-hydroxyvitamin D, then mediated again in the kidneys by 1-alpha-hydroxylase to finally become calcitriol, or the active form of vitamin D3, known as 1,25 dihydroxyvitaminD3.
Important: If we shower every day, we “wash off” most the 7-dehydrocholesterol, preventing any pre-vitamin D from forming in the first place.
In addition, as we age, we lose the ability to synthesise Vitamin D3 from sunlight, and those on statin medications such as Lipitor, Zocor, Simvastatin etc (half the aged population) cannot make 7-dehydrocholesterol in the liver, so no Vitamin D3 results.
Also as we age, we generate less stomach acid, losing the ability to take in B12, folate, vitamin K2 and other nutrients that Vitamin D3 requires to do it’s job.
Those who dress fully covered for cultural reasons or those with dark skin always need more Vitamin D3.
Annual blood tests for Vitamin D3 are advisable. For adults, toxic levels for Vitamin D3 are not seen unless we take in some 40,000 IU daily for some months.
Supplement values vary, and the RDA (recommended Daily Allowance) of 60 IU was alarmingly too low, and changed to 400 IU, originally determined as the minimum amount to prevent rickets, but research on immunity was not carried out.
Conservative studies determine that infants less than one year old need 400 IU daily, 1 year to adolescents need 400-600 IU daily, adults need 400-600 IU daily, and adults aged over 70 years need 400-800 IU daily.
I recommend everyone past adolescents take 1000 IU daily, over 35 take 2000 IU, over 50 take 5000 IU, over 70 take 8000 IU daily.
Small doses are fine for strong bones, but for a strong immune system to ward off all disease, high doses are a must.
LeanMachine has taken 5000 IU daily for 10 years, and gets plenty of sun where possible, and has zero colds, flu or any other illness, not even a headache in 10 years, and allergies disappeared! Recently LeanMachine has been taking 10,000IU of Vitamin D3 three days a week, as this is less expensive, and being fat-soluble, is stored in the body for much longer than the water-soluble vitamins.
More info on Vitamin D3 and sunlight here.

Treating Autism

We must understand how autistic children process information, to better design education and activities to improve outcomes.
Children with autism invariably have low vitamin D, and this was thought to be because they spent more time indoors, which obviously could be part of the problem.
However, studies show time after time that vitamin D is essential for balance, coordination and muscle control, which are all old-age symptoms, but often appearing in afflicted children.
All items below may help:

    • Avoid the following:

      • Avoid antibiotics
      • Avoid genetically modified food, invariably contaminated with weedkiller (Glyphosate or Roundup)
      • Avoid foods high in sugar, especially fructose
      • Avoid grains containing gluten – cereals, bread, cakes, cookies, pretzels, anything made from wheat flour
      • Avoid pasta, white potatoes and other high-carbohydrate, high GI foods
      • Avoid pasteurised milk, whey, cream, yoghurt, ice cream and any additive containing casein.
      • Avoid mouldy environments and throw out any mouldy food
      • Avoid tap water or treat water with Reverse Osmosis to reduce fluoride, chlorine and heavy metals
      • Avoid pesticides, herbicides, mercury, aluminium and fluoride
      • Avoid heavy metals, aluminium, preservatives, MSG, artificial colouring, flavourings, in food, soap, shampoo, anything going into or on the body
      • Reduce exposure to electromagnetic radiation from wi-fi, mobile phones, electrical wiring, etc
      • Reduce emotional stress (difficult to do) as a violent reaction to violent behaviour trains the child to repeat that behaviour

Vitamin D3 and Cholesterol During Pregnancy

Vitamin D3 and cholesterol during pregnancy can help protect children from autism.
Cholesterol is a building block for the brain, and vitamin D3 is essential for development of the brain and the Central Nervous System.
If mothers have low vitamin D3, they cannot pass enough vitamin D3 through the placenta for correct foetal development.
Autistic and Asperger’s children have been found to have low cholesterol levels as well as low vitamin D3 levels.
Pregnant women need vitamin D3 levels above 50 ng/ml or 125 mmol/L for development of the brain and central nervous system in the foetus, which can help prevent autism.

Summary

Prevention is always better than treatment for any condition.
There is no magic bullet to cure autism, but science has been too busy looking for such a cure, science has ignored the main preventions:
Gut Health, vitamin D3, toxic environments.
These recommendations are all good for children and adults alike to maintain physical and mental health right through to very old age.

Diet for Autism

See this article and others at www.greenmadinfo.com
Children with autistic spectrum disorders require special dietary management due to their lower plasma concentration of magnesium

LeanMachine Supplements

Disclaimer

LeanMachine is not a doctor, and everyone should consult with their own health professional before taking any product to ensure there is no conflict with existing prescription medication.
LeanMachine has been studying nutrition and health since 2011 and has completed many relevant studies including:
Open2Study, Australia – Food, Nutrition and Your Health
RMIT University, Australia – Foundations of Psychology
Swinburne University of Technology, Australia – Chemistry – Building Blocks of the World
University of Washington, USA – Energy, Diet and Weight
Johns Hopkins Bloomberg School of Public Health, USA – Health Issues for Aging Populations
Johns Hopkins Bloomberg School of Public Health, USA – International Nutrition
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics I
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics II
Johns Hopkins Bloomberg School of Public Health, USA – Principles of Human Nutrition
TUFTS University, USA – Nutrition and Medicine
TUFTS University, USA – Lipids/Cardiovascular Disease I and Lipids/Cardiovascular Disease II
Technical Learning College, USA – Western Herbology, Identification, Formulas
Bath University, England – Inside Cancer
WebMD Education – The Link Between Stroke and Atrial Fibrillation
WebMD Education – High Potassium: Causes and Reasons to Treat
Leiden University Medical Center, Netherlands – Anatomy of the Abdomen and Pelvis
MIT (Massachusetts Institute of Technology) – A Clinical Approach to the Human Brain

LeanMachine has now examined thousands of studies, journals and reports related to health and nutrition and this research is ongoing.

UCopyright © 1999-2019 Brenton Wight and BJ & HJ Wight trading as Lean Machine abn 55293601285

Why we need B12, B6, Active Folate and TMG

Written by Brenton Wight – LeanMachine, Health Researcher
Updated 2nd December 2019, Copyright © 1999-2019 Brenton Wight and BJ & HJ Wight trading as Lean Machine abn 55293601285

Vitamin B12

Vitamin B12, or Cobalamin, is part of the B group of vitamins, but is different in three respects:

  • The B12 molecule is the largest and most complex vitamin known.
  • B12, like the rest of the B-group vitamins, is water-soluble, but B12 is the ONLY water-soluble vitamin which can be stored in the liver for months, or even years
  • B12 is generally formed in the high-acid stomach, but those with low acid levels cannot form B12.

Benefits of B12

  • Protects brain cells, improves nerve growth and conduction, increasing speed of messages to and from the brain
  • Protects the myelin sheath surrounding nerve cells.
  • Protects against Alzheimer’s and other brain-degenerative diseases
  • Mental clarity, concentration, memory, nervous system
  • Circulation
  • Aids in turning food carbohydrates into glucose for energy
  • Fat metabolism, digestion
  • Helps produce DNA and RNA, the genetic material in our cells
  • Increases iron utilisation to build red blood cells, preventing anemia
  • With B9 (folate), helps the manufacture of S-adenosylmethionine to reduce depression and boost the immune system
  • With B9 (folate) and B6, B-12 inhibits homocysteine production, an amino acid linked to heart disease.
  • Adrenal hormone function
  • Energy – physical, emotional, mental

B12 is only found in animal products, apart from mushrooms, which are the only vegetable (actually a fungus) containing B12, but the B12 exists only in the skin of the mushroom which is often peeled off and discarded, and in any case, this is a poor food source of B12.
This is why vegetarians, and especially vegans should take additional B12 supplements.
The elderly are also at risk for B12 deficiency, because as we age, the level of stomach acid tends to drop, and once it drops below a certain point, this ends the conversion process that generates the B12 that can be absorbed.
Many diets recommend that we limit protein from animal products, but this is very wrong. LeanMachine has been a vegetarian for over 40 years, but regularly eats eggs and fish for B12 intake. Even so, B12 levels were low the first time they were checked at around age 64. Since then, daily B12 supplements have built B12 levels to around five times the normal amount. We cannot overdose on B12, unlike Folate and other vitamins.
Unfortunately many doctors never test for B12, and if we are deficient in B12, doctors typically misdiagnose this deficiency, resulting in prescribing drugs that do not help the condition, but may even create side effects that only make us feel worse!
Some PPI (Proton Pump Inhibitor) medications such as Nexium, prescribed for reflux, heartburn and other digestive issues, deliberately lower stomach acid, and there are many off-the-shelf antacids which do the same, and all result in knocking out our Vitamin B12. Note also that microwaving food also knocks out all B12.

Symptoms of B12 deficiency

  • Anaemia
  • Macrocytosis (larger than normal red blood cells)
  • Hypersegmented neutrophils (Nuetrophil blood cells with more lobes than normal)
  • Fatigue, lack of energy
  • Weak legs
  • Forgetfulness, mental fogginess
  • Mood swings, lack of motivation
  • Depression, paranoia, delusions
  • Yellow colour
  • Feelings of apathy
  • Loss of appetite
  • Hair loss
  • Rapid heart rate (Tachycardia)
  • Shallow breathing, short of breath
  • Unintended weight loss
  • Bleeding or bruising more than normal
  • Persistent constipation or diarrhea
  • Dizziness
  • Incontinence
  • Loss of taste and smell
  • Sore tongue or mouth
  • Bones which easily break, even if a DEXA scan says they are dense
  • Tingling in fingers or toes
  • Strange nerve sensations
  • Muscle Tenderness

Untreated, a severe B12 deficiency may lead to permanent nerve damage.
Not everyone with low B12 will have all symptoms, but having a few of these suggests testing for B12 and Folate.

Who is at Risk?

  • Those aged over 50
  • Vegans, vegetarians
  • Those taking antacids
  • Those on PPI (Proton Pump Inhibotor) medications, e.g. Nexium
  • Diabetics taking Metformin (Diabex)
  • Those having surgery where part of the stomach is removed
  • Those with Ceoliac Disease
  • Those with bacterial overgrowth, stomach and intestines
  • Alcoholics
  • Those taking some anti-seizure medications
  • Those drinking too much water

Research suggests that in the over-50 age group, more than 20% of the population are low in B12, and a fifth of those are seriously deficient.

Recommended Daily Allowance for B12

Official recommended dietary amounts (RDAs) are:

  • Infants 0-6 months, 0.4 mcg
  • Infants 7-12 months, 0.5 mcg
  • Children 1-3 years, 0.9 mcg
  • Children 4-8 years, 1.2 mcg
  • Children 9-13 years, 1.8 mcg
  • Adults: 2.4 mcg daily for ages 14 years and older
  • Pregnant Females: 2.6 mcg daily
  • Breastfeeding Females: 2.8 mcg daily
  • Adults over 50 years old: 20 mcg daily

However, LeanMachine has the opinion that these amounts are way too low. If anyone has any symptoms of deficiency, testing and subsequent supplementation may be required, but beware of cheap supplements containing cyanocobalamin (an artificial chemical made from cyanide) and only use methylcobalamin which is the active form of Vitamin B12. Even though the cyanide in cheap B12 is fairly harmless, and easily excreted into urine, the methyl version can be used directly by the body without conversion, and contributes to the important methylation process, which occurs over a billion times per second in the body.
LeanMachine recommends Active B12 1500mcg 60 vcaps

Testing Vitamin B12

It is important to test Folate at the same time as B12, because a deficiency in one can mask a deficiency in the other.
Blood Test for B12 deficiency:
For a long time, the reference range in Australia has been 135 to 650 pmol/L (pica moles per litre) but this is way too low.
In the 1980’s, Japan lifted their low end of the range to 500, and for those people with the defective MTHFR gene (up to 40% of the population), even this can be too low.
LeanMachine recommends 750 to 1500 as a more desirable range. LeanMachine uses B12 supplements, and tests at the top end of this range.
However, a high B12 reading does not always mean a satisfactory level.
When B12 is low, two enzyme substrates will increase: tHcy (total homocysteine) and MMA (methylmalonic acid). If deficiency symptoms do not go away, these should also be tested.

Treating Low Vitamin B12

Memory loss is a significant symptom, and if diet and/or supplementation is improved within one to two years, full memory can often be restored, but after two years, permanent memory damage may have occurred.
Ideally, we should look at the diet first, and if this does not improve B12, then B12 supplements are essential. If deficiency symptoms are severe, immediate supplementation or a B12 injection is advised.
Because B12 can be stored in the body, B12 injections are only required every 3 months to maintain healthy levels.
Here are some food sources of vitamin B12, arranged from highest to lowest:

Type of Food mcg of B12/serving % of RDA
Shellfish (Clams) 85g/3oz 84 1400
Liver, beef 85g/3oz 70.0 1178
Shellfish (Oysters) 85g/3oz 84 408
Crab, raw, 85g/3oz 9.8 163
Trout, rainbow, wild, cooked, 85g/3oz 5.4 90
Salmon, sockeye, cooked, 85g/3oz 4.9 80
Red Meat (Beef) 85g/3oz 5.1 85
Yogurt, plain, 1 cup 1.4 25
Haddock, cooked, 85g/3oz 1.2 20
Egg (chicken), one extra-large 0.5 20

Chicken is missing from the table above, because one egg has as much B12 as nearly half a chicken. Another case for the egg coming before the chicken!

Who should NOT take Vitamin B12
In those with Leber’s Disease (Leber Hereditary Optic Neuropathy, or LHON, a rare eye disease affecting less than 1 in 50,000) B12 can seriously damage the optic nerve, so B12 should never be taken.

Homocysteine – an inflammatory marker

Homocysteine levels in the blood are a marker of inflammation and cardiovascular disease, and low levels of Vitamin B12 and Folate can raise Homocysteine levels.
High homocysteine levels usually lead to cognitive decline in advancing years, cardiovascular disease, Alzheimer’s disease and many other ageing-related diseases.
Homocysteine is produced in the body as a result of demethylation of methionine utilisation of fats and proteins.
In Australia, doctors seldom order a Homocysteine blood test unless we ask for it. This test can also check for a rare inherited disorder called homocystinurina. The risk for homocystinurina is low, but it is best to rule it out.
If there is a family history of high homocysteine, children should be tested from birth.
The main purpose of the Homocysteine test is to determine if you have increased risk for heart attack or stroke, and a deficiency in B12 and Folate, and all should be tested at the same time.

What is Homocysteine?

Homocysteine is an amino acid, one of the building blocks of proteins. We can not get homocysteine from the diet.
Homocysteine can only be made from methionine, another amino acid that is found in meat, fish, and dairy products, and this reaction can only happen with enough Vitamin B6 (pyridoxine), Vitamin B12 and folate.
Foods containing methionine are transformed into homocysteine in the blood, and then Vitamin B6 helps convert homocysteine to cysteine. Vitamin B12 related enzymes can also recycle homocysteine back into methionine.
Cysteine is a very important protein, involved in how proteins in cells are folded, maintain their shape, and link to each other, and cysteine is a source of sulfide, taking part in metabolism of iron, zinc, copper and other important minerals. Cysteine also acts as an anti-oxidant. If homocysteine cannot be converted into cysteine or returned to the methionine form, levels of homocysteine in the body increase. Elevated homocysteine levels have been associated with heart attack, stroke, blood clot formation, and perhaps the development of Alzheimer’s disease.

Homocysteine Test

Laboratories generally say that normal homocysteine serum levels are between 4 and 15 micromoles per litre, with anything above 15 considered high.
However, the OPTIMAL level of homocysteine is less than 10 or 12 in good labs, but many doctors will ignore readings unless they are flagged on the report (above 15).

CRP  (c-Reactive Protein)

C-Reactive Protein is another important marker for inflammation and risk for strokes, and should be tested if homocysteine results are inconclusive.
Healthy people should ask for the High-Sensitivity test, hs-CRP.
Those in poor health should ask for the regular CRP test, which is not as sensitive, but has a much wider range of values.

Folate, Folic Acid, Folinic Acid, Active Folate

These all sound similar, but most forms have to be converted in the body to the active form that the body can use: MTHF or (6S)-5-MethylTetraHydroFolate, commonly calles Active Folate.
Up to 40% of the population have a MTHFR gene polymorphism. The MTHFR gene helps make  methylenetetrahydrofolate reductase, an enzyme involved in processing amino acids, the building blocks of proteins.
Unfortunately, consumption of Folic Acid can aggravate this MTHFR gene polymorphism, making the problem worse, blocking the real folate, increasing cancer risk and causing other health problems.

Treating High Homocysteine

Because homocysteine is missing CH3 (the methyl group), the best way to lower homocysteine is to add a methyl donor, which will aid the breakdown of homocysteine into methionine.
The following are all methyl donors:

Studies

In a 2-year study of people aged over 70 with elevated Homocysteine levels over 11.3 micromoles/litre, patients were given either a placebo or Folic Acid 800mcg, Vitamin B12 500mcg, and Vitamin B6 20mg daily.
Most of those on the placebo showed distinct cognitive decline. Those on the supplements showed no decline or much more moderate decline.

  • A 2-year study of people aged 60 to 74 with symptoms of depression using smaller doses and only Folic Acid 400mcg and Vitamin B12 100mcg taken twice daily, showed small but significant improvements in short-term and long-term memory
  • An 8-year study of several hundred people in their seventies showed that those having the lowest levels of B12 in their blood (under 257 pmol/l), 40% of the group, had the highest rates of cognitive decline. Formerly, the official danger point for B12 was set at 148 pmol/l (picomoles per litre), but this study confirms that this level is too low, and that most people aged 50 or over should either consume foods fortified with B12 or take supplements
  • A 2-year study showed that B12 and Folic Acid supplements significantly reduced the risk of Alzheimer’s Disease
  • A study found that although bone density remained the same in the B12 and Folate group as well as the placebo group, the number of bone fractures was 80% less in the supplement group.
    It appears that high homocysteine levels interfere with the way collagen works to strengthen bone

Food Sources of B Vitamins

All B-group vitamins come primarily in meat and eggs, the only exception being mushrooms as the only “vegetable” with B-group vitamins).
ALL vegetarians and especially vegans should supplement with Active B12 and Active Folate.
Almost all seniors need B12 because of reduced stomach acid as we age, and anyone taking statin drugs (e.g. Simvastatin, Lipitor, etc for Cholesterol) or heartburn medication (Nexium) (or off-the-shelf remedies) MUST supplement with B12 because stomach acid will not be strong enough for the body to produce any B12 at all.

As we age, we also lose our ability to absorb B12, B6 and Folate from foods, so most people over 50 should supplement.
Many younger people are also deficient in B-group vitamins due to diet, health, lifestyle, genetic makeup or illness, so annual blood tests are recommended for everyone.

Around 20% of the population suffer from Folate deficiency, but too much Folate (over 1000mcg or 1mg daily) can be toxic to the liver.
However, we cannot overdose on B6 or B12. No side-effects have ever been observed at extremely high doses.

TMG – TriMethylGlycine

The TMG molecule consists of three methyl groups (CH3) and one glycine group (C2H5NO2).

The advantage of TMG is that it can donate all three methyl groups, leaving pure glycine.

Glycine is very important for body functions, including:

  • Build lean muscle mass
  • Preventing sarcopenia (muscle loss, muscle wasting)
  • Producing human growth hormone
  • Improving memory and mental performance
  • Reducing risk of strokes and seizures
  • Protecting skin from aging and cell mutations
  • Increasing collagen in joints, reducing joint pain
  • Improving flexibility and range of motion
  • Lowering blood glucose, reducing risk of type 2 diabetes
  • Improving sleep quality
  • Reducing inflammation and free radical damage
  • Increasing glutathione production
  • Reducing risk for some cancers
  • Building gastrointestinal tract lining
  • Producing bile salts and digestive enzymes
  • Reducing allergic and autoimmune reactions
  • Increasing energy levels, fighting fatigue
  • Increasing red blood cell production
  • Reducing stress,  anxiety
  • Controlling symptoms: seizures, schizophrenia, mental disorders

The following are my recommended supplements:

LeanMachine Supplements

Disclaimer

LeanMachine is not a doctor, and everyone should consult with their own health professional before taking any product to ensure there is no conflict with existing prescription medication.
LeanMachine has been studying nutrition and health since 2011 and has completed many relevant studies including:
Open2Study, Australia – Food, Nutrition and Your Health
RMIT University, Australia – Foundations of Psychology
Swinburne University of Technology, Australia – Chemistry – Building Blocks of the World
University of Washington, USA – Energy, Diet and Weight
Johns Hopkins Bloomberg School of Public Health, USA – Health Issues for Aging Populations
Johns Hopkins Bloomberg School of Public Health, USA – International Nutrition
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics I
Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics II
Johns Hopkins Bloomberg School of Public Health, USA – Principles of Human Nutrition
TUFTS University, USA – Nutrition and Medicine
TUFTS University, USA – Lipids/Cardiovascular Disease I and Lipids/Cardiovascular Disease II
Technical Learning College, USA – Western Herbology, Identification, Formulas
Bath University, England – Inside Cancer
WebMD Education – The Link Between Stroke and Atrial Fibrillation
WebMD Education – High Potassium: Causes and Reasons to Treat
Leiden University Medical Center, Netherlands – Anatomy of the Abdomen and Pelvis
MIT (Massachusetts Institute of Technology) – A Clinical Approach to the Human Brain

LeanMachine has now examined thousands of studies, journals and reports related to health and nutrition and this research is ongoing.

Updated 2nd December 2019, Copyright © 1999-2019 Brenton Wight and BJ & HJ Wight trading as Lean Machine abn 55293601285