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Macular Degeneration

Copyright © 1999-2020 Brenton Wight, LeanMachine, Health Researcher
Updated 3rd April 2020, Copyright © 1999-2020 Brenton Wight and BJ & HJ Wight trading as Lean Machine

Macular image
AMD (Age-related Macular Degeneration) is a type of central vision loss.
Central vision is essential for driving, reading, facial recognition, etc. The macula is an area covering only 2.1% of the retina, and 5.5mm diameter, but the most important.
AMD is the leading cause of vision impairment in the over-40s in Australia.
Normal macular grid

If we look at the black dot in the grid here, one eye at a time, we should see perfectly straight lines and the black dot in the centre.

 

 

 

 

Distorted macular grid

If we view the same grid but see any distortion in the chart, as this sample of advanced AMD vision, or if there is smudging or invisible areas, see an optometrist or ophthalmologist as soon as possible.

 

 

 

Types of AMD

Wet and Dry forms of macula
1. Dry AMD (atrophic AMND) is the most common.
2. Wet AMD affects only around 20% of sufferers, but is more serious.
Note: Often confused with Epiretinal membrane, often called a macular pucker, which can cause similar symptoms, but is quite different. This is a thin, almost transparent layer of fibrous cellular material, released from the retina and other parts of the eye into the vitreous gel that then settles to form a film over the macula, affecting vision. Epiretinal membranes can resolve on their own, and mild conditions may not need further attention. In some cases, Vitrectomy surgery may be required, involving removal and replacement of some or all of the vitreous humor (fluid or gel) from the eye, and lifting the film from the macula. Has a fairly good success rate.

Age-related is a misnomer

Doctors say the cause of AMD is unknown, but as it happens more in seniors, it is age-related, or genetic.
But the evidence now points to diet rather than age.
Dr. Chris Knobbe, Ophthalmologist and founder and president of the Cure AMD Foundation, believes that the skyrocketing rates of AMD worldwide are actually caused by the increased consumption of processed food, and has nothing to do with age or genetics.
Before 1925, there were about 50 reports of macular degeneration world-wide, even though Ophthalmologists had instuments to view the macula from the 1860’s.
Macular degeneration became only slightly more common in the 1940’s.
In 1975, over 4 million Americans had macular degeneration.
In 2019 there are over 180 million people with Macular Degeneration, and it is predicted that by 2040 this number will grow to over 280 million.
Research is now clearly pointing to processed foods as the culprit, mainly margarine, canola oil and other factory-produced franken-foods, already proven to cause cancer, cardiovascular disease, blood pressure, obesity, diabetes, stroke, and now AMD as well.

Preventing AMD

As there is no “cure” for AMD, prevention is our best option. Dietary changes can help prevent AMD, and at the same time, prevent cardiovascular, cancer, stroke, blood pressure, diabetes, obesity, Alzheimer’s and more.
Apart from the diet, we need to get more quality sleep, by eliminating blue light (computer screens) and sleeping in total darkness.

AMD Symptoms

AMD has no symptoms in the early stages.
Later symptoms include:

  • Distortion, but sometimes blur or missing image in central vision
  • Reduced definition of colours, or dim colour vision
  • Central vision blocked by dark shapes
  • Difficulty with close work, e.g. reading
  • Central vision loss

Macular degeneration does not cause any pain.
See an optometrist or ophthalmologist as soon as possible if you notice any symptoms, or have any distortion on the chart.
Depending on the type of AMD, there are treatments, diet and lifestyle changes that can slow or stop vision loss, and may even improve vision.

High risk groups:

  • Those over 60
  • Family history of AMD
  • Smoking = 3 x risk
  • Obesity
  • Those working with computer, phone or TV screens
  • Caucasians have a higher risk than other races
  • Those with high blood pressure
  • Diet containing trans fats
  • Cardiovascular disease
  • Females have higher risk

Smoking damages the retina, and increases risk of AMD an average of 3 fold. The retina requires a lot of oxygen, which is depleted in smokers.

Cause of AMD

Doctors still cannot pin-point a cause, but there are many things to help prevent or treat the condition.

Official AMD Treatment

Dry AMD Official medical treatments available for dry AMD appear to be very limited.
For now, positive changes to diet and lifestyle slows disease progression.
Note: Dry AMD can progress to wet AMD, so any sudden changes in vision should be immediately reported.
More info at: www.mdfoundation.com.au/content/dry-macular-degeneration-1
Wet AMD
The protein VEGF (Vascular Endothelial Growth Factor) is mainly responsible for leaking and growth of new blood vessels that result in rapid and severe vision loss, which if left untreated, becomes permanent.
Anti-VEGF drugs can be injected into the eye to slow or stop the AMD process.
Monthly injections are used for three months, then continued on an indefinite basis at an interval determined by the ophthalmologist in consultation with the patient. Injection treatment advice:
Injection treatment is not long, and normally carried out in the ophthalmologist’s rooms, but sometime in a day surgery facility.
Anaesthetics are given pre-injection, to reduce discomfort. If there is no apparent change in vision, appointments should still be kept to ensure there really is no change.
The Amsler grid should be used daily for each eye, any sudden vision changes should be reported urgently. Treatment may still require continuation, even if vision has stabilised or improved.
Read more: www.mdfoundation.com.au/content/wet-macular-degeneration

Stem Cell Technology

Scientists in Sweden innovated a method of treating blindness using embryonic stem cells to produce retinal cells. The team at Karolinska Institutet and St Erik Eye Hospital reported in March 2020, their approach of using CRISPR/Cas9 gene editing to amend retinal cell production so the generated cells can hide from the body’s immune system, protecting them from becoming rejected. Read more:
www.news-medical.net/news/20200330/Developments-in-treating-blindness-using-retinal-cell-production.aspx

Drugs for AMD

Lucentis® (Lampalizumab) is a drug that binds to Complement Factor D, a protein which is encoded by the CFD gene in humans.
It is a treatment for dry AMD, but appears to work best in patients with complement-risk genes. Genetic testing may be appropriate if this treatment is considered.

Eylea® (Aflibercept) is an anti-VEGF drug developed for wet AMD.
Avastin® (Bevacizumab) is an anti-VEGF drug, originally developed as a cancer drug. Not registered by the TRGA (Therapeutic Goods Administration) for use in the eye, so this use is “off-label”. Typically used for Australians not eligible for the approved drugs Lucentis or Eylea via POBS (Pharmaceutical Benefits Scheme).

Laser Treatments

PDT (Photodynamic Therapy) combines Visudyne, a light-activated drug, with cool laser light, directed on the relevant retinal area to seal and halt or slow progression of abnormal retinal blood vessels. The patient MUST avoid sunlight for 24 to 48 hours after drug infusion.
Patients having PDT usually continue to lose vision in the first six months of treatment, but then usually stabilises, halting severe vision loss, where anti-VEGF drugs start working faster.
PDT is now rarely used for normal AMD, but sometimes used with an anti-VEGF drug for patients with the polypoidal choroidal vasculopathy type of AMD, as this condition does not settle completely using anti-VEGF drugs alone.

Laser photocoagulation uses a concentrated beam of high-energy thermal light, directed to the retina to destroy and seal leaky blood vessels. The laser also destroys the retina adjacent to the blood vessel, so is used mainly to treat a small percentage of wet AMD patients who have new vessels not in the central vision.
Laser photocoagulation has a 50% recurrence rate, so close follow up and monitoring is essential.

Natural treatment for AMD

Food is vital, but only natural food, nothing processed. Processed foods are anything found in a supermarket on a box, bag, can etc.
Natural foods are only found in the greengrocery section, preferably in the organic area.
We should all aim for all foods in this area, with at least one meal daily as raw food, because we must have enzymes for optimum health and immunity.
Enzymes in raw food are destroyed by heating to over 50 degrees C (122 degrees F) which is about the temperature of hot water at the kitchen sink in most homes.
When cooking food, steaming is best. If we heat food over 120 degrees C (148 defrees F) by baking in the oven or frying etc, then AGEs (Advanced Glycation End-products) are formed from proteins or fats, which, just like the AGE acronym, cause premature ageing, and a much higher risk for AMD as well as glaucoma, cataracts and other eye disease, as well as blood pressure, strokes, heart attacks, brain disease, diabetes and other “modern” disease that did not exist 100 years ago.
Best foods are green leafy vegetables, broccoli, brussels sprouts, cabbage, lettuce, capsicum, cucumber, lemons, bananas, apples, spinach and berries of all kinds.
Eggs are great, with Nature’s perfect packaging, but should be boiled for 10 minutes to destroy any pathogens, and not fried or any other high-temperature methods.
Limited full-fat dairy is fine unless there are allergies, but low-fat dairy should be avoided, as the nutrition is in the fat, not in the water.
Fish has Omega-3 fatty acids that benefit the eyes as well as the heart and brain. Again, steaming is the best way to cook fish.
Coconut Oil was used in an animal study to show significant reduction in caspase-3 activity (a protease enzyme causing inflammation and apoptosis).
Coconut oil helped protect the integrity of healthy cells in retinas through an anti-apoptotic mechanism, supporting a direct link between caspase-3 and progression of light-induced retinal degeneration.
Coconut oil is one of the healthiest oils we can consume, also boosting brain function in a single dose, increasing HDL (“good” cholesterol), reducing body-mass index (BMI) and waist circumference. Coconut oil reduces wound-healing time when applied topically.

Supplements for AMD prevention

The AREDS (Age-Related Eye Disease Study) found benefits of high dose supplements that helped prevent or treat AMD, and recommended that those diagnosed with AMD or at high risk should use these supplements as a guide.
The original AREDS study of zinc and antioxidants slowed progression of AMD by 20% to 25% for those in the intermediate or late stage of AMD, and delayed vision loss. The follow-up AREDS2 study included lutein/zeaxanthin.
The AREDS2 formula (daily dose):

  • Zinc (as zinc oxide) 80mg
  • Vitamin C 500mg
  • Vitamin E 400IU
  • Copper (as cupric oxide) 2mg
  • Lutein 10mg
  • Zeaxanthin 2mg

However, LeanMachine regards most of these ingredients as sub-standard or even harmful, even though they helped those in the study.
One example of a product NOT to buy:
Bausch & Lomb, PreserVision, AREDS 2 Formula claims to conform to AREDS2 formula, but LeanMachine does not endorse this product.
Their Vitamin E is a synthetic dl-alpha-tocopherol (natural versions have a “d” prefix, d-alpha-tocopherol, where a “dl” prefix means an artificial product), and does not contain tocotrienols or the beta, gamma and delta versions of each, which make up the 8 components of Vitamin E.
Also it contains titanium dioxide (brain and nerve damage and a Group 2B carcinogen)
Titanium dioxide image
Also contains food dyes red #40 and blue #1 (can be contaminated with cancer-causing agents).
Contains Cupric oxide, but negligible copper is absorbed from this form.
Zinc oxide is dangerous and can damage DNA.

While healthy foods will help delay AMD, as well as reducing risk of diabetes, cardiovascular disease, Alzheimers, obesity, other eye disease and more, there is often not enough healthy content available to give the AMD patient enough of the correct nutrition, due to intensive farming practices, combined with toxic chemical additives in the soil.
Lean Machine recommends a combination of a healthy diet, supplements and sun exposure for optimum nutrition.
Oxidative stress is a major factor in progression of AMD, so antioxidants are important.
Various vitamins and minerals have been proven to reduce AMD symptoms, but eye doctors seldom pass on this information.
Supplements do not make up for a bad diet. Supplements often only supply a single important extract, but whole, natural foods contain fibre, enzymes and many other important compounds, so LeanMachine recommends a combination of both.
The following are the main supplements LeanMachine recommends for AMD patients:

  • OptiZinc is much better absorbed and much safer than zinc oxide. Also includes copper, but not enough, see chelated copper below
  • Vitamin C
     – Pure pharmaceutical grade ascorbic acid powder is economical and effective. 1/4 teaspoon daily is 1250mg, more than enough for AMD, and added benefit for preventing or slowing progression of cataracts
  • Vitamin E
     contains the extra 4 tocotrienols missing from cheap vitamins. Also good for the heart
  • Chelated Copper is much better absorbed, and much safer than Cupric Oxide. Note: Metallic copper is bad for the body. Copper cookware should not be used, and a Reverse Osmosis system should be used for all drinking and cooking to help eliminate fluoride, metallic copper, lead, arsenic, aluminium and other toxins
  • Lutein with Zeaxanthin. Lutein is extremely important as an antioxidant for eye health. This product includes OptiLut which increases lutein bio-availability, and also includes zeaxanthin

LeanMachine also recommends the following as added protection for AMD:

In addition, mitochondria health is essential. Foods improving mitochondria are:
1. Proteins such as fish, nuts, seeds, beans, lentils, eggs that support Glutathione and other amino acids which protect the mitochondria.
2. Antioxidants – colourful vegetables, fresh fruit, herbs, spices, berries. Best spices are cloves and turmeric.
Supplements for Glutathione include:

Inform the doctor of any other medical conditions and any other medications, vitamins or mineral supplements.

Other Eye Disease

Many other conditions affect sight, and I will discuss these later in separate articles. Of course, it is quite possible to have more than one condition, so early diagnosis is essential so we are more likely to be dealing with the first condition without confusing treatment with two or more conditions.
Here are a few of the most common:

  • Epiretinal membrane is often confused with Macular Degeneration, but is a film over the Macula
  • Diabetic Retinopathy affects blood vessels in the retina, and is the most common cause of vision loss among diabetics.
  • glaucoma affects peripheral vision.
  • Cataracts where the lens gradually becomes opaque
  • CMV Retinitis an infection of the retina, often affecting those with poor immunity or with AIDS
  • Diabetic Macular Oedema caused by fluid accumulation in the macula causing severe blurred vision
  • Retinal Detachment the retina separates from the nerve tissue and blood supply underneath it
  • Uveitis is inflammation of one or more of the uvea, the nerve tissue, and/or blood supply underneath. Common with Sarcoidosis

Eye Checkups

Everyone should get an annual eye check.
Most people are first checked by an optometrist, and when a problem is found they are normally referred to an ophthalmologist.
First, after a quick eye chart test, with and without glasses, amblyopia (“lazy eye”) is tested by covering one eye and looking for movement in the other eye, also ocular motility testing to determine how well the eyes follow a moving object, and stereopsis or depth perception.
Then a refraction test checks the degree of hyperopia (farsightedness), myopia (nearsightedness), astigmatism and presbyopia to determine a prescription of any eye-glasses required.
Eye drops are used to enlarge the pupils and allow better scrutiny of the inner eye.
Warning:These drops can last 4 to 6 hours, and when the patient ventures out into bright light, the pupils cannot respond quickly by reducing the pupil size, so glare and blurred vision can make driving or other activities dangerous, but everyone has a different reaction, and sun glasses are a must.
The doctor uses a “slit lamp” and checks the eyelids, cornea, conjunctiva, iris, and lens. Conditions are checked for retinal detachment, dry eye, blocked tear ducts, drainage problems, cataracts, macular degeneration, corneal ulcers, diabetic retinopathy and other eye disease.
The retina is examined and usually retina photographs are taken for reference in future tests to check for any change.
Typical Retina Photograph

Colour blindness is normally checked using the Ishihara Color Vision Test booklet, each page containing a circular pattern comprising many dots of various colors, brightness and sizes, making up a single digit number. The full test contains 38 fifferent pages, but a basic test will only involve 14 or 24 different pages. A colour-blind person will see no number, or a different number in this test. Any problems in colour blindness may indicate a health problem such as glaucoma, MS (multiple sclerosis), diabetic retinopathy, macular edema and other disorders, as well as color vision issues caused by long-term use of some prescription medications.
For colour-blind people, specially tinted glasses can improve the distinguishment and vividness of various colours as a vision aid.
The retina has cone photoreceptors, and the red and green cones are often most affected, causing “red-green colour blindness”.

Foods to avoid

  • Baked foods. Gluten from wheat products damages the gut, even if we are not diagnosed as a Celiac.
    All baked goods are not natural, contain very little nutritional value, and have been subjected to high temperatures causing AGEs
  • Processed meats, as almost all cold meats contain sulfite or nitrite preservatives (chemical numbers in the 200 series) which are known to cause cancer and Alzheiner’s
  • Soft drinks, as almost all contain 211 or other 200 series chemical preservatives that cause cancer, as well as sugar and/or artificial sweeteners that also cause cancer
  • Fruit juices, as many have added sugar and/or preservatives, etc. Better to eat a piece of fruit, as the fibre aids gut bacteria and digestion, and the chewing slows down consumption. Immunity starts in the mouth, with saliva starting the breakdown of food. This benefit disappears when gulping down juice
  • Anything fried and almost everything else at the take-away counter. If we need take-away food, try a fresh apple and keep the doctor and the ophthalmologist away
  • Low-fat anything. Fat-reduced foods have been processed, and usually fats have been replaced with sugar, one of the worst culprits for inflammation and disease of all types
  • Any foods with added or “fortified” iodine, folic acid, iron, vitamin D, etc as invariably these are cheap supplements and are quite often causing damage to the body by blocking uptake of the real nutrients in food
  • Bad fats – Margarine – do not be fooled by unscrupulous advertising from margarine manufacturers who claim that margarine reduces cholesterol. Maybe it does at first, but cholesterol is not our enemy, only OXIDISED Very Low LDL is bad, and that is the main ingredient in margarine. Alternative: Coconut oil, butter, cold olive oil.
  • Canola oil – heat processing in production oxidises this fat. Cooking with canola oil oxidises the fat even more. NEVER use canola oil for anything.
    Alternative: Coconut oil
  • Sunflower Oil – similar problem to canola oil. Flaxseed or coconut oil is a much healthier alternative.

 

Bad drugs

  • Paracetamol, panadol, acetaminophen, tylenol – different names for the same drug marketed as “safe and effective” but it destroys L-Glutathione, the body’s own master antioxidant, and damages the liver. Around 90% of patients on the liver transplant waiting list are there because of paracetamol overdose. Alternatives for pain:
    (a) MSM – primarily for joint pain but helps reduce the sensation of any pain.
    (b) Bacopa – primarily for slight blood thinning and higher brain function, but also helps with pain
  • Statins – cholesterol lowering drugs that increase risk of diabetes, clobber our Vitamin D, cause muscle pain, liver and kidney disease, reduced immunity, and on average may slightly reduce risk of a heart attack but increase death risk from all other causes, so most people taking statins will not live one day longer, and have a poor quality of life
  • Aspirin increases risk of Wet AMD by causing leakage of blood vessels under the macula, causing scar tissue.
    Do not take aspirin for cardiovascular disease or pain, as the risks for internal bleeding and/or Wet AMD outweigh any advantages. Read more in my Blood Thinner article

Cooking Methods

The best cooking method is NONE. Heating food over around 50 degrees Celcius (about the temperature of hot water at the kitchen sink) destroys most or all of the beneficial enzymes, so salads, fruit or other cold foods should be consumed at least once daily. An organic apple a day keeps the doctor and the ophthalmologist away…
The second best cooking method is STEAMING, which means a maximum of 100 degrees Centigrade (212 degrees F). Other cooking methods heat food well over the safety limit of 120 degrees Centigrade. Over 120 degrees C, AGEs (Advanced Glycation End-products) form, which change the chemical structure of the food, causing damage to the mitochondria and many body systems.
Microwaving also damages the chemical structure of food, and studies show negative blood test results in humans after consuming microwaved food.
LeanMachine Health Supplements

Disclaimer

LeanMachine is not a doctor, and everyone should consult with their own health professional before taking any product to ensure there is no conflict with existing prescription medication.
LeanMachine has been studying nutrition and health since 2011 and has completed many relevant studies including:

  • Open2Study, Australia – Food, Nutrition and Your Health
  • RMIT University, Australia – Foundations of Psychology
  • Swinburne University of Technology, Australia – Chemistry – Building Blocks of the World
  • University of Washington, USA – Energy, Diet and Weight
  • Johns Hopkins Bloomberg School of Public Health, USA – Health Issues for Aging Populations
  • Johns Hopkins Bloomberg School of Public Health, USA – International Nutrition
  • Johns Hopkins Bloomberg School of Public Health, USA – Methods in Biostatistics I & II
  • Johns Hopkins Bloomberg School of Public Health, USA – Principles of Human Nutrition
  • TUFTS University, USA – Nutrition and Medicine
  • TUFTS University, USA – Lipids/Cardiovascular Disease 1 & II
  • Technical Learning College, USA – Western Herbology, Identification, Formulas
  • Bath University, England – Inside Cancer
  • WebMD Education – The Link Between Stroke and Atrial Fibrillation
  • WebMD Education – High Potassium: Causes and Reasons to Treat
  • Leiden University Medical Center, Netherlands – Anatomy of the Abdomen and Pelvis
  • MIT (Massachusetts Institute of Technology) – A Clinical Approach to the Human Brain
  • LeanMachine has now examined thousands of studies, journals and reports related to health and nutrition and this research is ongoing

Disclaimer: Any information here is for educational purposes, and the needs of each individual varies, so everyone should consult with their own health professional before taking any product to ensure that there is no conflict with existing prescription medication.
LeanMachine has been researching nutrition and health since 2010, and has now examined thousands of studies, journals and reports related to health and nutrition and this research is ongoing.
Copyright © 1999-2020 Brenton Wight and BJ & HJ Wight trading as Lean Machine abn 55293601285

Can glutathione help combat fatty liver disease?

Reproduced from original article:
www.naturalhealth365.com/glutathione-liver-disease-3311.html

glutathione-detox(NaturalHealth365) Glutathione – a powerful antioxidant that’s found within every cell of the body – is made up of amino acids. This antioxidant contributes to a variety of important bodily functions, including vitamin regeneration, breaking down free radicals, immune system support, helping the liver to handle fats, making DNA, and even the creation of sperm cells.  But, unlike many other antioxidants, the body is actually able to make this substance in your liver.

Researchers have previously found links between certain diseases and low glutathione levels.  Since the antioxidant plays an important role in the antioxidant and detoxification systems of cells, scientists hypothesized that glutathione supplementation would help combat fatty liver disease.  And in a fairly recent study, researchers investigated oral supplementation in individuals with nonalcoholic fatty liver disease (NAFLD) with positive results.

The proper amount of glutathione proves to be beneficial for people with fatty liver disease

The study involved 34 patients with nonalcoholic fatty liver disease, all of whom had been diagnosed via ultrasonography. First, patients underwent lifestyle interventions, such as diet and exercise changes for a period of three months.

Then, patients were treated with 300 mg per day of glutathione. Clinical parameters like liver fat, liver fibrosis, and alanine aminotransferase (ALT – a blood test that checks for liver damage) levels were all checked both before and after treatment with glutathione.

Among the patients who finished this protocol, a significant decrease in ALT levels were seen after treatment with glutathione.  Patients also so decreases in ferritin, triglyceride, and non-esterified fatty acid levels.

Overall, the study demonstrated that oral supplementation of glutathione does offer some significant potential therapeutic effects for patients with fatty liver disease, although study authors note that larger-scale clinical trials should be done for verification.

Do NOT ignore the health dangers linked to toxic indoor air.  These chemicals – the ‘off-gassing’ of paints, mattresses, carpets and other home/office building materials – increase your risk of headaches, dementia, heart disease and cancer.

Get the BEST indoor air purification system – at the LOWEST price, exclusively for NaturalHealth365 readers.  I, personally use this system in my home AND office.  Click HERE to order now – before the sale ends.

Powerful antioxidant offers additional health benefits

Beyond this new study showing the benefits of glutathione for individuals with liver disease, the powerful antioxidant offers a number of additional health benefits as well.

Benefits include:

  • Counteracting free radicals: As an antioxidant, it helps fight free radicals, protecting your body from their damaging and aging effects.
  • Improves insulin sensitivity: One study showed that individuals who have insulin resistance often have low glutathione levels.
  • Combating cancer: Some research shows glutathione may help prevent cancer progression as well.
  • Alleviate symptoms of Parkinson’s: Research shows that maintaining healthy levels of glutathione may help alleviate or at least reduce symptoms associated with Parkinson’s disease.
  • Boosting the immune system: By protecting cell mitochondria and reducing inflammation, glutathione helps boost the immune system.

Although glutathione offers a number of proven health benefits, as you grow older, levels of glutathione decrease.  Injury, stress, and illness can all affect glutathione stores, as well.

Therefore, eating an organic diet, reducing or eliminating smoking and alcohol consumption, and avoiding exposure to environmental toxins can help prevent glutathione depletion.  Naturally, adding a glutathione supplement to your diet in the amount of 200 – 500 mg per day may also prove helpful, although you should always talk to your integrative physician before making any changes to your diet or supplement routine.

Sources for this article include:

NIH.gov
NaturalHealth365.com
MedicalNewsToday.com

Siim Land Interviews Dr. Mercola About ‘EMF*D’


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2020/02/29/5g-health-hazards.aspx

Analysis by Dr. Joseph Mercola     

STORY AT-A-GLANCE

  • Electromagnetic fields (EMFs) cause massive mitochondrial dysfunction, thus raising the risk for, and worsening, chronic and degenerative diseases
  • A perfect storm of DNA and cellular protein and membrane destruction is created when you aren’t burning fat for fuel (which creates excess superoxide) and then get exposed to EMFs
  • By creating doubt and controversy, the wireless industry effectively prevents the public from knowing the truth and demanding safer products. Another wireless industry strategy that prevents the problem from becoming public knowledge is the capturing of our federal regulatory agencies
  • Elon Musk’s Starlink project, which is slated to deploy up to 42,000 satellites into orbit around the earth, will blanket the entire planet with 5G internet frequencies. You won’t be able to escape it
  • Based on the studies already done on previous generations of wireless, we know it’s harmful, and 5G is only going to make matters worse, as it will dramatically increase our exposures

I was recently interviewed by Siim Land about my new book, “EMF*D,” described by Siim as “the most comprehensive guide … to everything you need to know about EMF.”

In it, I explain what electromagnetic fields (EMFs) are, the different types of EMFs you’re exposed to, the harms associated with exposure, the concerns surrounding 5G and, ultimately, how to protect yourself and limit your exposure.

As I explain in the interview, the thing that catalyzed me to write “EMF*D” was my deep appreciation of the impact of mitochondrial function in health and disease. Once I realized how EMFs impact mitochondrial function — because it’s very clear that EMF causes massive mitochondrial dysfunction — the danger our wireless society poses became very clear to me.

Just recently, I read a study1 stressing the importance of mitochondrial numbers for improving senescent cells — cells that are, in a manner of speaking, “senile” and have stopped reproducing properly. Instead, senescent cells produce inflammation, contributing to old age and, ultimately, death.

The fewer mitochondria you have, and the more dysfunctional they are, the faster you’ll age and the more prone you’ll be to chronic degenerative disease. By inducing mitochondrial dysfunction, our wireless world may well be driving us all into an early grave.

Cellphone Industry Hides Truth by Manufacturing Doubt

Considering the research data now available, you’d think everyone would understand and accept the fact that EMF is a serious health danger, yet many are still completely in the dark. With “EMF*D,” I hope to help more people understand this biological threat.

In 2011, the World Health Organization’s International Agency for Research on Cancer (IARC) classified radiofrequency EMFs as “possibly carcinogenic to humans.”2 Then, in 2018, the U.S. National Toxicology Program published two lifetime exposure studies conclusively showing cellphone exposure causes cancer.

The NTP’s findings were also duplicated by the Italian Ramazzini Institute just a couple of months later. In the wake of these studies, Fiorella Belpoggi, principal investigator and director of the Ramazzini Institute, urged the IARC to upgrade RF-EMF to “probably carcinogenic” or higher.3

Now, just like smoking cigarettes, EMF exposure takes decades before its effects become evident (and even then, the health problem might not be directly linkable to EMF exposure), and this is a significant part of the problem as it allows the telecom industry to — just like the tobacco industry before it — whitewash concerns, manipulate research and prevent proper safety studies from being done.

There’s no doubt cellphone manufacturers are aware that EMFs from cellphones contribute to health problems, though. The evidence has been published for decades, and new research is constantly being added.

However, by downplaying positive findings and saying that findings of harm are inconclusive — in other words, by creating doubt and controversy — they effectively prevent the public from knowing the truth and demanding safer products.

Wireless Industry Is Even Worse Than the Tobacco Industry

Another wireless industry strategy that prevents the problem from becoming public knowledge is the capturing of our federal regulatory agencies, which the tobacco industry wasn’t even capable of.

The U.S. Environmental Protection Agency, the Surgeon General and the Centers for Disease Control and Prevention all warned people about smoking, yet the tobacco industry continued successfully selling cigarettes for another 20 or 30 years. The wireless industry, on the other hand, has captured the federal regulatory agencies, which prevents those warnings from being issued in the first place.

For example, the chief lobbyist for the wireless industry, Tom Wheeler, was appointed by President Obama to be the head of the Federal Communications Commission, which is a most egregious example of the fox guarding the hen house. Not surprisingly, then, in December 2019 the FCC announced they’re going to fund rural 5G deployment to the tune of $9 billion!4

As detailed in my February 1, 2020, article, “The War Against 5G Heats Up,” the telecom industry has engaged in a vast and illegal fraud where, for decades, basic telephone rate payers — wire line customers — have funded the deployment of wireless in general, and now 5G in particular, through their phone bills.

This illegal redirection of funds amounts to about $1 trillion over the past 15 years, and without this money, 5G would not have been possible in the first place. Were the wireless industry forced to pay its fair share of infrastructure costs, 5G simply wouldn’t be economically feasible as a consumer product.

What’s so Great About 5G?

What exactly is 5G and why do some people want it? In short, it’s all about improving speed. Compared to 4G, 5G is 100 times faster. On a side note, you can determine what your bandwidth is by pulling up fast.com on your cellphone’s browser. If you’re on 4G, your bandwidth is probably not going to exceed 10 megabytes per second (mb/s). If you’re on 5G, it’s going to be between 500 and 800 mb/s.

So, the primary benefit of 5G is noticeably faster speed. The vast majority of people simply don’t need this kind of bandwidth, but it has great applications for commercial uses such as self-driving cars.

The problem is, 5G may end up making the earth uninhabitable for many who are already struggling with electrosensitivity, and the countless others for whom 5G may prove to be the thing that tips them over the edge into electrohypersensitivity syndrome.

Elon Musk’s Starlink project, which is slated to deploy up to 42,000 satellites into low earth orbit, will blanket the entire planet with 5G internet. You won’t be able to escape it, no matter how far into the wilderness you go.

5G Is a Prescription for Biological Disaster

Then there are the long-term dangers of 5G, which we still do not have a complete picture of. There has not been a single safety study done on 5G. Studies using 2G, 3G and 4G, however, including the NTP and Ramazzini studies, clearly show there’s cause for concern.

5G is more complex, as it uses a variety of frequencies, which makes it a potentially greater threat. The frequency of 4G is typically around 2 to 5 gigahertz (GHz), while 5G will be around 20 to 30 GHz, initially.

Eventually, it may go as high as 80 GHz, which will cause problems for people trying to remediate exposures because there are currently no inexpensive meters that can measure frequencies that high.

Based on the studies already done on previous generations of wireless, we know it’s harmful, and 5G is only going to make matters worse, as it will dramatically increase our exposures. 5G requires what essentially amounts to a mini cellphone tower outside every fifth or sixth house on every block.

We also have studies showing the impact of millimeter waves, which is what 5G is using, on insects, animals and plants, and those hazards are well-documented. So, it doesn’t just pose a problem for human health, but for the ecosystem as a whole.

Martin Pall, Ph.D., wrote an excellent paper explaining how EMFs affect your voltage gated calcium channels (VGCCs) — channels in the outer plasma membrane of your cells. Each VGCC has a voltage sensor, a structure that detects electrical changes across the plasma membrane and opens the channel. EMFs work through the voltage sensor to activate the channel and radically increase intracellular calcium levels into dangerous ranges.

Similar channels are found in most biological life, including animals, insects, plants and trees. So, flooding the planet with these frequencies will undoubtedly have serious biological consequences across the ecosystem. As such, it’s an existential threat to humanity.

One biological consequence is arrhythmia (irregular heartbeat). Other potential consequences include autism and Alzheimer’s. Heart and neurological problems top the list because your heart and brain have the greatest density of VGCCs. Men’s testes also have a very high density of VGCCs and, indeed, we have evidence showing EMFs increase men’s risk of infertility.

Everything points to these frequencies being a prescription for biological disaster, and between skyrocketing autism, Alzheimer’s and infertility rates, how can a society be sustained? It can’t. It will be extinguished.

We Don’t Need Wireless 5G

In reality, we can still get the bandwidth of 5G without 5G wireless. The alternative would be to deploy fiber optic cable. It’s faster, safer and less expensive.

Unfortunately, the money originally set aside to implement nationwide fiber optics was rerouted and illegally used to build the wireless infrastructure instead. This is why a group called The Irregulators5 are now suing the FCC to put a stop to the illegal subsidy to the wireless industry.

Wireline customers paid for an upgrade to fast and safe fiber optic wiring across the nation, but now we’re getting harmful 5G wireless instead. As explained in “The War Against 5G Heats Up” (hyperlinked above), this lawsuit has the potential to alter the telecommunications industry from the ground up, and may be the “weapon” we need to halt to the 5G rollout in the U.S.

The Importance of EMF Avoidance to Protect Your NAD+ Level

Along with practical remediation strategies, “EMF*D” also covers things you can do to protect yourself on a biochemical level. A perfect storm of DNA and cellular protein and membrane destruction is created when you aren’t burning fat for fuel (which creates excess superoxide) and then get exposed to EMFs.

This causes a radical increase in nitric oxide release that nearly instantaneously combines with superoxide to create enormous levels of peroxynitrate, which triggers a cascade of destructive events to your cellular and mitochondrial DNA, membranes and proteins.

Although all biologic damage is of concern, it is the DNA strand breaks that are most concerning as they will lead to a radical increase in inflammation and virtually all degenerative diseases.

The good news is your body has the ability to repair this damaged DNA with a family of enzymes called poly ADP ribose polymerase or PARP It is a very effective repair system and works wonderfully to repair the damage as long as it has enough fuel in the form of NAD+.

The bad news is many of us are running low on this fuel. When excess peroxynitrate activates PARP to repair the DNA damage, it consumes NAD+, and if you run out, you can’t repair the damage. This appears to be a central cause for most of the diseases we now see in the modern world.

Optimizing your NAD+ levels may be the single most important strategy for improving your mitochondrial health. The first step is to reduce NAD+ consumption by the correct diet (low in processed foods and net carbohydrates and higher in healthy fats), along with EMF avoidance, as recent research shows NAD+ levels dramatically drop when exposed to EMFs.

Time restricted eating is also very helpful, as is exercise, both of which are powerful, inexpensive and safe ways to boost your NAD+ level.

Helpful Strategies to Limit EMF Damage

In “EMF*D” I also cover the Nrf2 pathway and the importance of minerals such as magnesium to limit the biological damage caused by EMFs. As explained in this interview, upregulating your Nrf2 pathway activates genes that have powerful antioxidant effects, thus helping protect against EMF damage, while magnesium — which is a natural calcium channel blocker — helps reduce the effects of EMF on your VGCCs.

On a side note, molecular hydrogen tablets are an excellent source of ionic elemental magnesium. Each tablet provides about 80 milligrams of ionic elemental magnesium.

Addressing EMF Pollution — A 21st Century Health Imperative

There’s no doubt in my mind that EMF exposure is an important lifestyle component that needs to be addressed if you’re concerned about your health, which is why I spent three years writing “EMF*D.”

My aim was to create a comprehensive and informative guide, detailing not only the risks, but also what you can do to mitigate unavoidable exposures. To get you started, see the tips listed in my previous article, “Top 19 Tips to Reduce Your EMF Exposure.”

If you know or suspect you might already be developing a sensitivity to EMFs (full-blown hypersensitivity can often strike seemingly overnight), mitigating your exposures will be particularly paramount. Many sufferers become obsessed with finding solutions, as the effects can be severely crippling. My book can be a valuable resource in your quest for relief.

The EMF Experts website6 also lists EMF groups worldwide, to which you can turn with questions, concerns and support, and EMFsafehome.com7 lists a number of publications where you can learn more about the dangers of EMFs.

Should you need help remediating your home, consider hiring a trained building biologist to get it done right. A listing can be found on the International Institute for Building-Biology & Ecology’s website.8

Brian Hoyer, a leading EMF expert9 and a primary consultant for “EMF*D” also has a company called Shielded Healing that can provide a thorough analysis of the EMF exposure in your home, and help you devise a remediation plan. You can listen to our excellent three-hour interview for more information, featured in “Your EMF Questions Answered Part 1” and “Your EMF Questions Answered Part 2.”

Vitamin C Works for Sepsis. Will It Work for Coronavirus?


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2020/02/24/iv-vitamin-c.aspx
Analysis by Dr. Joseph Mercola

February 24, 2020
iv vitamin c

STORY AT-A-GLANCE

  • Sepsis is responsible for 1 in 5 deaths worldwide each year, killing 11 million out of 56 million people in 2017 alone. Sepsis is also one of the leading causes for influenza deaths
  • An IV protocol has been shown to dramatically improve chances of survival in septic patients. Giving adult patients 200 mg of thiamine every 12 hours, 1,500 mg of ascorbic acid every six hours, and 50 mg of hydrocortisone every six hours for two days reduced mortality from 40% to 8.5%
  • Recent research has demonstrated the vitamin C-hydrocortisone-thiamine protocol lowers mortality in pediatric patients as well, from 28% to 9% in the first 30 days
  • In 2009, IV vitamin C was shown to be a potentially lifesaving treatment against severe swine flu. Even before that, many studies had demonstrated the usefulness of vitamin C against infections of various kinds
  • A randomized double-blind study published in 1994 found elderly patients given 200 milligrams of vitamin C per day while hospitalized for acute respiratory infection fared significantly better than those receiving a placebo

According to the most comprehensive global analysis1,2,3 done to date, sepsis is responsible for 1 in 5 deaths worldwide each year, killing 11 million out of 56 million people in 2017 alone. The researchers call the finding “alarming,” as their updated figures are double that of previous estimates.

Sepsis is a life-threatening condition triggered by a systemic infection that causes your body to overreact and launch an excessive and highly damaging immune response.

Unless promptly diagnosed and treated, it can rapidly progress to multiple-organ failure and death, so it’s crucial to be on the lookout for its signs and symptoms4,5,6 whenever you’re ill or in the hospital.

This includes cases of suspected influenza, as sepsis can mimic many of the signs and symptoms of flu. In fact, as discussed in “The Alarming Reason Some People Die From the Flu,” sepsis is one of the leading causes for influenza deaths.7

Vitamin C Protocol Lowers Sepsis Mortality

The good news is, a protocol of intravenous (IV) vitamin C with hydrocortisone and thiamine (vitamin B1) has been shown to dramatically improve chances of survival.8

This sepsis treatment protocol was developed Dr. Paul Marik, a critical care doctor at Sentara Norfolk General Hospital in East Virginia. His retrospective before-after clinical study9,10 showed giving patients 200 mg of thiamine every 12 hours, 1,500 mg of ascorbic acid every six hours, and 50 mg of hydrocortisone every six hours for two days reduced mortality from 40% to 8.5%.

Importantly, the treatment has no side effects and is inexpensive, readily available and simple to administer, so there’s virtually no risk involved. More recent research,11,12 published online January 9, 2020, found Marik’s sepsis protocol lowered mortality in pediatric patients as well.

The study was performed at Ann & Robert H. Lurie Children’s Hospital of Chicago, and as noted by Science Daily,13 the preliminary data from this study “supports the promising outcomes seen in adults.” Between January 2014 and February 2019, 557 pediatric patients with septic shock met the criteria for inclusion in the study.

Forty-three received Mariks’s vitamin C-B1-hydrocortisone protocol, 181 received hydrocortisone-only therapy, and 333 received neither of these treatments. The 43 patients receiving the vitamin C treatment were matched based on clinical status with 43 untreated controls and 43 hydrocortisone-only patients.

At the 30-day mark, controls and the hydrocortisone-only groups had a mortality rate of 28% while the treatment group had a mortality rate of just 9%. At 90 days, 35% of the controls and 33% of those receiving hydrocortisone-only had died, compared to just 14% of the treatment group.14

As noted by the authors, “Our results suggest that HAT [hydrocortisone, ascorbic acid and thiamine] therapy, when administered early in the clinical course, reduces mortality in children with septic shock.”

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Vitamin C Put to the Test Against Coronavirus

In 2009, IV vitamin C was shown to be a potentially lifesaving treatment against severe swine flu. Even before that, many studies had demonstrated the usefulness of vitamin C against infections of various kinds.

For example, a randomized double-blind study15 published in 1994 found elderly patients given 200 milligrams of vitamin C per day while hospitalized for acute respiratory infection fared significantly better than those receiving a placebo.

According to the authors, “This was particularly the case for those commencing the trial most severely ill, many of whom had very low plasma and white cell vitamin C concentrations on admission.”

Now, vitamin C will be put to the test against coronavirus as well. The study,16 “Vitamin C Infusion for the Treatment of Severe 2019-nCoV Infected Pneumonia” was posted to ClinicalTrials.gov February 11, 2020, and has not yet started recruiting patients. According to the study description:17

“At the end of 2019, patients with unexplained pneumonia appeared in Wuhan, China … Subsequently, the World Health Organization officially named the new coronavirus that caused the pneumonia epidemic in Wuhan as 2019 new coronavirus (2019-nCoV), and the pneumonia was named severe acute respiratory infection (SARI).

Up to February 4, 2020, over 20,000 cases have been diagnosed in China, 406 of which have died, and 154 cases have been discovered in other countries around the world. Most of the deaths were elderly patients or patients with severe underlying diseases …

Statistics of the 41 patients with SARI published in JAMA initially showed that 13 patients were transferred into the ICU, of which 11 (85%) had ARDS and 3 (23%) had shock. Of these, 10 (77%) required mechanical ventilation support, and 2 (15%) required ECMO support. Of the above 13 patients, 5 (38%) eventually died and 7 (38%) were transferred out of the ICU.

Viral pneumonia is a dangerous condition with a poor clinical prognosis … Vitamin C, also known as ascorbic acid, has antioxidant properties. When sepsis happens, the cytokine surge caused by sepsis is activated, and neutrophils in the lungs accumulate in the lungs, destroying alveolar capillaries. Early clinical studies have shown that vitamin C can effectively prevent this process.

In addition, vitamin C can help to eliminate alveolar fluid by preventing the activation and accumulation of neutrophils, and reducing alveolar epithelial water channel damage. At the same time, vitamin C can prevent the formation of neutrophil extracellular traps, which is a biological event of vascular injury caused by neutrophil activation.”

The researchers intend to treat patients with 24 grams of IV vitamin C per day for seven days at a speed of 7 milliliters per hour. The placebo group will receive an IV of normal saline.

The primary outcome measure will be the number of days without ventilation support during 28 days of hospitalization. Secondary outcome measures will include mortality, ICU length of stay, the rate of CPR required, vasopressor use, respiratory function, sepsis-related organ failure and more.

Time will tell what the outcome will be, but chances are it will be favorable. Back in 2003 during the SARS pandemic, a Finnish researcher called for an investigation into the use of vitamin C, stating:18

“Recently, a new coronavirus was identified as the cause of the severe acute respiratory syndrome (SARS). In the absence of a specific treatment for SARS, the possibility that vitamin C may show nonspecific effects on several viral respiratory tract infections should be considered.

There are numerous reports indicating that vitamin C may affect the immune system, for example the function of phagocytes, transformation of T lymphocytes and production of interferon. In particular, vitamin C increased the resistance of chick embryo tracheal organ cultures to infection caused by an avian coronavirus.19

He goes on to cite research showing vitamin C also protects broiler chicks against avian coronavirus, cuts the duration and severity of common cold in humans and significantly lowers susceptibility to pneumonia. Unfortunately, it doesn’t appear as though vitamin C was ever studied in relation to SARS, but it’s encouraging that China is now investigating its use against 2019-nCoV.

Health Benefits of Vitamin C Are Vastly Underappreciated

Vitamin C has two major functions that help explain its potent health benefits. First, it acts as a powerful antioxidant. It also acts as a cofactor for enzymatic processes. One of the most famous forerunners of high dose vitamin C treatment for colds and other disease was Linus Carl Pauling (1901-1994), a biochemist who won the Nobel Prize in chemistry in 1954.

Despite that, many felt he was too far out of his field of expertise with his research into nutrition, and his advocacy for vitamin C was largely ignored or mocked by mainstream medicine and nutritional science — with medical bloggers leading the pack as self-appointed judges of Pauling’s findings.20

Others, however, have picked up on what Pauling was trying to point out, and are now trying to awaken the world to just how important vitamin C is for good health and vitality.21 As explained by the Linus Pauling Institute:22

“Vitamin C is the primary water-soluble, non-enzymatic antioxidant in plasma and tissues. Even in small amounts vitamin C can protect indispensable molecules in the body, such as proteins, lipids (fats), carbohydrates, and nucleic acids (DNA and RNA), from damage by free radicals and reactive oxygen species (ROS) that are generated during normal metabolism, by active immune cells, and through exposure to toxins and pollutants …”

According to Dr. Ronald Hunninghake, an internationally recognized expert on vitamin C who has personally supervised tens of thousands of IV vitamin C administrations, vitamin C is “definitely a very underutilized modality in infectious disease,” considering “it’s really a premiere treatment” for infections.

In my interview with him, Hunninghake suggested one of the reasons why conventional medicine has been so slow to recognize the importance of vitamin C has to do with the fact that they’ve been looking at it as a mere vitamin, when in fact it’s a potent oxidizing agent that can help eliminate pathogens when given in high doses.

There are also financial factors. In short, it’s too inexpensive. Conventional medicine, as a general rule, is notoriously uninterested in solutions that cannot produce significant profits.

However, considering sepsis is now the most expensive condition treated in the U.S., costing $23.6 billion annually,23,24 the need for an affordable solution is becoming critical. This is particularly true for lower income nations, where an estimated 85% of sepsis-related deaths occur.25 Global pandemics like the coronavirus also call for lower-cost treatments that actually work.

Recognize the Symptoms of Sepsis

When it comes to sepsis, which can result from just about any infection, time is of the essence. It’s really important to familiarize yourself with its signs and symptoms, and to take immediate action if you suspect sepsis.

While the signs can be subtle at first, sepsis typically produces the following signs and symptoms:26,27,28 Many of these symptoms may be confused with a bad cold or flu. However, they tend to develop quicker than you would normally expect.

A high fever with chills and shivering Rapid heartbeat (tachycardia)
Rapid breathing (tachypnea) Unusual level of sweating (diaphoresis)
Dizziness Confusion or disorientation
Slurred speech Diarrhea, nausea or vomiting
Difficulty breathing, shortness of breath Severe muscle pain
Low urine output Cold and clammy skin and/or skin rash

The Sepsis Alliance recommends using the acronym TIME to remember some of the more common symptoms:29

  • T — Temperature higher or lower than normal?
  • I — Have you now or recently had any signs of an infection?
  • M — Are there any changes in mental status, such as confusion or excessive sleepiness?
  • E — Are you experiencing any extreme pain or illness; do you have a “feeling you may die?”

Another acronym you could use to memorize the signs and symptoms is SEPSIS, described in the video above:

  • S — Shivering (fever, cold)
  • E — Extreme pain
  • P — Pale, clammy skin
  • S — Shortness of breath
  • I — “I feel like I might die”
  • S — Sleepy (confused)

Educational Resources for Your Doctor

Marik’s sepsis protocol can be a lifesaver, so you’d be wise to discuss it with your doctor any time you’re hospitalized. Remember, sepsis is often the result of a secondary infection contracted while in the hospital, so it’s prudent to be prepared.

This way, should you develop sepsis while you’re admitted, your medical team already knows your wishes and can act swiftly. According to Marik, the best results are obtained when the concoction is administered within the first six hours of presentation of symptoms.30 The longer you delay treatment, the less likely it will be successful.

If your doctor refuses to consider it offhand, convince him or her to review the studies cited here.31,32,33,34,35,36,37,38,39 While there are certain situations in which the hospital may still deny this treatment, if you are an adult who is sick, you will usually have the right to insist on it. I will actually be interviewing Marik shortly and hope to work with him on developing a process to make it easier for patients to implement this strategy in their local hospital.

In most cases, you’d probably just need to sign an “Against Medical Advice — Acknowledgment and Waiver” form (samples of which can be found in the references40), which states you’ve elected to not follow the standard of care recommended by your doctor.

Contraindication for IV Vitamin C Treatment

The only contraindication to high-dose vitamin C treatments such as Marik’s sepsis protocol is if you are glucose-6-phosphate dehydrogenase (G6PD) deficient, which is a genetic disorder.41 G6PD is required for your body to produce NADPH, which is a cousin of NAD+ and necessary to transfer reductive potential to keep your antioxidants, like glutathione and vitamin C, functional.

Because your red blood cells do not contain any mitochondria, the only way it can provide reduced glutathione is through NADPH, and since G6PD eliminates this, it causes red blood cells to rupture due to inability to compensate for oxidative stress.

Fortunately, G6PD deficiency is relatively uncommon, and can be tested for. People of Mediterranean and African decent are at greater risk of being G6PD deficient. Worldwide, G6PD deficiency is thought to affect 400 million individuals, and in the U.S., an estimated 1 in 10 African-American males has it. 42

– Sources and References

Boosting Mitochondrial Biogenesis With Ginger

© 18th January 2020 GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here www.greenmedinfo.com/greenmed/newsletter
Reproduced from original article:
www.greenmedinfo.com/blog/boosting-mitochondrial-biogenesis-ginger

Posted on: January 18th 2020 at 4:00 pm
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

The Importance of Melatonin for Optimal Health


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2020/02/06/melatonin-for-sleep.aspx

Analysis by Dr. Joseph Mercola Fact Checked image
February 06, 2020
melatonin for sleep

STORY AT-A-GLANCE

  • Your circadian rhythm is largely dictated by your pineal gland, located near the center of your brain, which produces melatonin, a hormone that is crucial for the regulation of your sleep cycle
  • Melatonin is also an important energy hormone and a potent antioxidant that appears to play an important role in cancer prevention. It also benefits your brain, cardiovascular and gastrointestinal health, and has been shown to boost immune function
  • Melatonin helps protect your mitochondria, which generate energy inside your cells. Melatonin appears to be the most powerful antioxidant in this regard, as it has the ability to enter into your mitochondria. It also recharges glutathione
  • Melatonin works synergistically with vitamin D to optimize mitochondrial function. It also enhances vitamin D signaling
  • Multiple sclerosis, cancer, neuropsychiatric disorders and high blood pressure are all examples of diseases that appear strongly linked to and affected by your vitamin D and melatonin status

Sleeping well is an essential strategy to optimize your health, and at the heart of it is your circadian rhythm. This is also known as your body clock. It’s a natural, biological timer present in every one of your cells that helps your body recognize sleepiness and wakefulness over a period of 24 hours.

Your circadian rhythm is largely dictated by your pineal gland, located near the center of your brain, which produces melatonin, a hormone that is crucial for the regulation of your sleep cycle.

If you have had enough exposure to bright light in the daytime, your pineal gland typically starts secreting melatonin around 9 p.m.1 As the amount of melatonin in your brain increases, sleepiness sets in as your body begins to prepare for sleep.

If you stay awake past dark, artificial light — especially that emitted by electronic devices — will inhibit your body’s melatonin production, so, ideally, you would stop using electronics at least an hour or two before bedtime to help increase melatonin production and maintain a steady circadian rhythm.

Melatonin Does More Than Control Sleep

While melatonin works as a natural sleep regulator, its biological effects don’t end there.2 It’s also a potent antioxidant3 that plays an important role in cancer prevention.4 It’s also thought to be important for brain, cardiovascular and gastrointestinal health,5 and has been shown to boost your immune function in a variety of ways.

In one study,6 researchers suggested melatonin may even improve the treatment of bacterial diseases such as tuberculosis. In another, melatonin was identified as a potential tool against inflammation and autoimmune diseases, including Type 1 diabetes.7

Melatonin is also an important energy hormone. As noted in the Stanford University course paper “Melatonin and Energy Levels:”8

“… decreasing the melatonin in the blood stream, consistent with the body’s natural response to suppress the secretion in the presence of light, causes the body to function at a higher energy level … An increase in the melatonin levels leads to a subsequent decrease in energy levels.

As such, understanding how to control and optimize the secretion and suppression of the melatonin for optimal hours of the day could help improve the treatment of sleep disorders and positively impact the energy levels of individuals.”

In short, if your sleep efficiency is impaired, meaning you’re not sleeping as deeply as you should, for as long as is ideal, then your energy level is going to be adversely affected.

Conversely, spending most of your daytime hours in poorly lit rooms, especially if you’re also exposed to excessive light after sunset, can impair your melatonin production, causing you to not sleep well.

Melatonin Protects Your Mitochondria

Importantly, the antioxidant activity of melatonin also helps protect your mitochondria, the tiny organelles inside your cells that generate most of the ATP or energy currency of your body. As noted in a 2007 paper in the Frontiers of Bioscience:9

“Melatonin is an ancient molecule present in unicellular organisms at the very early moment of life … The best-known actions of melatonin, currently supported by experimental and clinical data, include antioxidant and anti-inflammatory abilities, some of them involving genomic regulation of a series of enzymes.

Besides, melatonin displays anticonvulsant and antiexcitotoxic properties. Most of the beneficial consequences resulting from melatonin administration may depend on its effects on mitochondrial physiology.”

In fact, melatonin appears to be the most powerful antioxidant in this regard, as it has the ability to actually enter into your mitochondria.10 This is an ability that not all antioxidants have. According to this Frontiers of Bioscience paper,11 melatonin helps “prevent mitochondrial impairment, energy failure and apoptosis in oxidatively-damaged mitochondria.”

One of the things that makes melatonin so powerful is that it doesn’t just act as an antioxidant in and of itself; it also interacts with your body’s innate antioxidant system where it recharges glutathione.12 However, this brings us back to the importance of sleep.

Since melatonin is only released in response to darkness, and is easily and significantly inhibited by light (such as regular room lighting and electronic screens, after dark), your mitochondrial health will suffer if you do not take steps to optimize your sleep.

Aside from worsening your sleep quality and decreasing your sleep quantity, low melatonin production also increases oxidative stress, speeds up the aging process and raises your risk of degenerative diseases and chronic fatigue, thanks to its influence over your mitochondria.

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Melatonin Works Synergistically With Vitamin D

In my February 2, 2020, article “The Importance of Vitamin D for Optimal Sleep,” which features my interview with neurologist and sleep coach Dr. Stasha Gominak, I review the hidden influence vitamin D has on your sleep.

A paper13 that will be published in the May 2020 issue of The Journal of Steroid Biochemistry and Molecular Biology — which I was able to review early, parts of which I’m sharing with you here — sheds further light on this connection. Not only does melatonin enhance vitamin D signaling, the two molecules act synergistically to optimize your mitochondrial function.

As noted in this paper,14 “The biosynthetic pathways of vitamin D and melatonin are inversely related relative to sun exposure,” meaning both are dependent on properly timed exposure to the sun.

A hypothesis presented by the researchers is that vitamin D and melatonin “play an essential role as modulators of mitochondrial function and adaptation to circadian and seasonal variations.”

Additionally, “both molecules are involved in the homeostatic functioning of the mitochondria,” the authors point out, stressing that the mitochondria are, in fact, “the final common target for melatonin and vitamin D.” Furthermore:

“A deficiency of these molecules has been associated with the pathogenesis of cardiovascular diseases, including arterial hypertension, neurodegenerative diseases, sleep disorders, kidney diseases, cancer, psychiatric disorders, bone diseases, metabolic syndrome, and diabetes, among others.

During aging, the intake and cutaneous synthesis of vitamin D, as well as the endogenous synthesis of melatonin are remarkably depleted, therefore, producing a state characterized by an increase of oxidative stress, inflammation, and mitochondrial dysfunction …

Mitochondrial dysfunction has been related to the etiologies of many complex diseases where overactivation of the renin-angiotensin-aldosterone system (RAAS), vitamin D deficiency and the reduction of melatonin synthesis converge.

In this sense, experimental and clinical evidence indicates that inflammation, oxidative stress, as in mitochondrial dysfunction, are consistent with low levels of melatonin and vitamin D, and also represent risk factors connected with development and maintenance of prevalent acute and chronic pathologies.”

Melatonin-Vitamin D Combo Produces Strong Synergistic Effects

According to the 2020 paper in The Journal of Steroid Biochemistry and Molecular Biology,15 multiple sclerosis, cancer, neuropsychiatric disorders and high blood pressure are all examples of diseases that appear strongly linked to and affected by your vitamin D and melatonin status.

Interestingly, a 2012 study16 pointed out melatonin is “an overlooked factor in schizophrenia and in the inhibition of antipsychotic side effects.” Vitamin D deficiency has also been linked to a higher risk of schizophrenia,17,18 especially when levels are low during development.19

When combined in treatment, melatonin and vitamin D produce strong synergistic effects against cancer. Two separate studies20,21 have demonstrated the combination induces apoptosis and inhibits growth and division of breast cancer cells. In one of them, the combination resulted in “an almost complete cell growth arrest at 144 hours.”22

These effects were attributed (at least in part) to enhanced release of transforming growth factor beta 1 (TGF-β1), a type of cytokine that controls cell growth, proliferation, differentiation and apoptosis. Melatonin in combination with vitamin D has also been shown to protect against apoptotic ischemia-reperfusion injury in the kidney.23

Simple Ways to Optimize Your Melatonin and Vitamin D

The evidence suggests optimizing your melatonin production by making sure you sleep well at night may be a hidden key to maintaining mitochondrial health, which in turn is paramount for longevity and the prevention of virtually all chronic health problems.

However, while there are likely many benefits to supplementing with vitamin D and melatonin, it makes no sense to do so unless you are seeking to optimize your body’s own production.

The good news is it’s relatively simple and inexpensive to increase your melatonin and vitamin D levels. To optimize your vitamin D, I recommend getting sensible sun exposure on large portions of your body on a regular basis, ideally daily.

For further guidance, see “The Risks and Benefits of Sun Exposure.” If for whatever reason you cannot get sufficient amounts of sun exposure, consider taking a vitamin D3 supplement (along with a little extra vitamin K2 to maintain a healthy ratio between these two nutrients).

I personally have not taken any oral vitamin D for well over 10 years and my levels are typically over 70 ng/mL, even in the winter, but I have started taking sublingual melatonin as I am now older than 65, and believe there are benefits for such, even though I sleep in pitch dark and get bright sun exposure around 85% of the time during the day.

Optimizing your melatonin production starts with getting plenty of bright sunlight during the day, as this helps “set” your circadian clock. Then, as the evening wears on and the sun sets, you’ll want to avoid bright lighting.

Blue light from electronic screens and LED light bulbs is particularly problematic and inhibits melatonin the most. If you need lighting, opt for incandescent light bulbs, candles or salt lamps. The blue light from electronic screens can be counteracted by installing blue-blocking software such as Iris,24 or wearing blue-blocking glasses.

Additionally, an interesting paper25 in Nature Structural & Molecular Biology, published in 2017, highlights the usefulness of time-restricted eating to improve your sleep cycle. As noted in this paper:

“The robustness of the circadian clock deteriorates with aging. Two new studies show that aging reprograms the circadian transcriptome in a cell-type-dependent manner and that such rewiring can be reversed by caloric restriction …

Surprisingly, the expression of core clock genes and clock-controlled genes remained unchanged with aging, despite the drastic circadian reprogramming. Thus, the core clock machinery remains largely intact in old age, giving hope for the prospect of reversing aging-associated circadian reprogramming to potentially improve physiological functions.

Indeed, CR-induced robust reprogramming of the circadian transcriptome partially overlaps with the circadian transcriptome in young mice. Thus, the profound physiological impact of CR may be, in part, mediated by the reprogramming of the circadian clock …

Given that aging-associated accumulation of DNA damage in stem cells originates from exposure to mitochondrial stress and that the mitochondrial protective programs are repressed in aged adult stem cells, it is tempting to speculate that reactivating the mitochondrial protective programs may provide a means to reduce the accumulation of cellular damage and reverse aging-associated circadian reprogramming.”

– Sources and References

More Health Benefits of Quercetin Revealed


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2020/01/27/quercetin-benefits.aspx
Analysis by Dr. Joseph Mercola     Fact Checked image

January 27, 2020
quercetin benefits

STORY AT-A-GLANCE

  • Quercetin has been shown to combat inflammation and acts as a natural antihistamine. Several studies have highlighted quercetin’s ability to prevent and treat both the common cold and influenza
  • Another, less known benefit and use for quercetin includes the prevention and/or treatment of high blood pressure, cardiovascular disease, metabolic syndrome, certain cancers, gout, arthritis and mood disorders
  • A review of quercetin’s effect on metabolic syndrome found it significantly reduced fasting plasma glucose when taken for at least eight weeks at a dosage of 500 milligrams per day or more
  • Other recent research found quercetin has a beneficial impact on nonalcoholic fatty liver disease by ameliorating inflammation, oxidative stress and lipid metabolism
  • Quercetin also has the ability to trigger tumor regression by interacting with your DNA and activating the mitochondrial pathway of apoptosis (the programmed cell death of damaged cells)

Quercetin1 is an antioxidant flavonol found naturally in foods such as apples, plums, red grapes, green tea, elder flower and onions, just to name a few.2 According to a 2019 Market Watch report,3 the quercetin market is growing rapidly as its health benefits are becoming more widely known.

Quercetin has been shown to combat inflammation and acts as a natural antihistamine. In fact, its antiviral capacity appears to be the primary focus of many studies looking at quercetin’s benefits, and a number of studies have highlighted quercetin’s ability to prevent and treat both the common cold and influenza.4,5,6,7

But there are also other, less known benefits and uses for this supplement, including the prevention and/or treatment of:8

High blood pressure9 Cardiovascular disease10
Metabolic syndrome11 Certain kinds of cancer12
Nonalcoholic fatty liver disease (NAFLD)13 Gout14
Arthritis15 Mood disorders16
Longevity, thanks to its senolytic benefits (clearing out damaged and worn-out cells)17,18

Additionally, quercetin is also helpful for aluminum-induced neurodegenerative changes, such as those seen in Alzheimer’s, Parkinson’s and amyotrophic lateral sclerosis (ALS). As noted in a 2016 study:19

“Administration of quercetin (10 mg/kg body wt/day) reduced aluminum (10 mg/kg body wt/day)-induced oxidative stress (decreased ROS production, increased mitochondrial superoxide dismutase (MnSOD) activity).

In addition, quercetin also prevents aluminum-induced translocation of cyt-c, and up-regulates Bcl-2, down-regulates Bax, p53, caspase-3 activation and reduces DNA fragmentation …

Further electron microscopic studies revealed that quercetin attenuates aluminum-induced mitochondrial swelling, loss of cristae and chromatin condensation. These results indicate that treatment with quercetin may represent a therapeutic strategy to attenuate the neuronal death against aluminum-induced neurodegeneration.”

Quercetin Improves Metabolic Syndrome Traits

Among the most recent papers on this powerful antioxidant is a review20 published in the March 2019 issue of Phytotherapy Research, which looked at nine randomized controlled trials investigating quercetin’s effect on metabolic syndrome.

Metabolic syndrome refers to a cluster of conditions (including high blood pressure, high blood sugar, high triglyceride levels and fat accumulation around the waist) that raise your risk for Type 2 diabetes, heart disease and stroke.

While pooled findings found no effect on fasting plasma glucose, insulin resistance or hemoglobin A1c levels, further subgroup analyses revealed quercetin supplementation “significantly reduced” fasting plasma glucose in studies lasting at least eight weeks and in which dosages of at least 500 milligrams (mg) per day were used.

In studies that included people over the age of 45, “significant” reductions in insulin were also found when using a dosage of 500 mg per day or more. An earlier study,21 published in 2011, looked at quercetin’s effects on certain traits of metabolic syndrome.

This study focused specifically atherosclerosis and inflammation in men with the APOE genotype 3/3, 3/4 and 4/4, and found quercetin significantly decreased waist circumference, postprandial systolic blood pressure, postprandial triacylglycerol, and increased HDL-cholesterol compared to placebo. Here, participants were given 150 mg of quercetin per day for eight weeks.

Research22 on obese rats published in 2008 also found that quercetin supplementation at doses of 2 mg per kilo or 10 mg/kg of body weight for 10 weeks improved systolic blood pressure, triglyceride, total cholesterol and free fatty acid levels. The 10 mg/kg dose also improved the animals’ inflammation status. As noted by the authors:

“In conclusion, both doses of quercetin improved dyslipidemia, hypertension, and hyperinsulinemia in obese Zucker rats, but only the high dose produced antiinflammatory effects in VAT together with a reduction in body weight gain.”

One of the first studies23 to demonstrate quercetin’s beneficial effects on blood pressure was published in 2007. As reported by the authors:

“Epidemiological studies report that quercetin … is associated with reduced risk of coronary heart disease and stroke … Men and women with prehypertension and stage 1 hypertension were enrolled in a randomized, double-blind, placebo-controlled, crossover study to test the efficacy of 730 mg quercetin/d for 28 d[ays] vs. placebo.

Blood pressure at enrollment was … 148 +/- 2/96 +/- 1 in stage 1 hypertensive subjects … Reductions in systolic (-7 +/- 2 mm Hg), diastolic (-5 +/- 2 mm Hg), and mean arterial pressures (-5 +/- 2 mm Hg) were observed in stage 1 hypertensive patients after quercetin treatment … These data are the first to our knowledge to show that quercetin supplementation reduces blood pressure in hypertensive subjects.”

Similarly, a January 2020 systematic review24 of 17 studies concluded quercetin “significantly decreased” blood pressure in human subjects. Those who took it for eight weeks or more also had “significantly” improved high-density lipoprotein cholesterol and triglycerides.

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Quercetin Improves Diabetes-Induced NAFLD

Other recent research25 published in the August 2019 issue of Phytotherapy Research concluded quercetin has a beneficial impact on NAFLD “by ameliorating inflammation, oxidative stress and lipid metabolism.”

Diabetes can play a role in NAFLD as well, showing just how influential insulin resistance is in the development of chronic diseases of all kinds. As explained in the abstract:

“Multiphase pathological processes involve in Type 2 diabetes (T2DM)‐induced nonalcoholic fatty liver disease (NAFLD). However, the therapies are quite limited. In the present study, the hepatoprotective effects and underlying mechanisms of quercetin in T2DM‐induced NAFLD were investigated …

The results revealed that quercetin alleviated serum transaminase levels and markedly reduced T2DM‐induced histological alterations of livers. Additionally, quercetin restored superoxide dismutase, catalase, and glutathione content in livers.

Not only that, quercetin markedly attenuated T2DM‐induced production of interleukin 1 beta, interleukin 6, and TNF‐α. Accompanied by the restoration of the increased serum total bile acid and the decreased liver total bile acid, quercetin could reduce lipid accumulation in the liver … These findings suggested that quercetin might be a potentially effective drug for the treatment of T2DM‐induced NAFLD.”

Quercetin Helps Modulate Gene Expression

According to research26 published in 2016, quercetin even has the ability to trigger tumor regression by interacting with your DNA and activating the mitochondrial pathway of apoptosis (the programmed cell death of damaged cells).

Quercetin was found to induce cytotoxicity in leukemic cells, and the effect was dose-dependent. Limited cytotoxic effects were also found in breast cancer cells. Overall, quercetin increased the life span in cancer-ridden mice fivefold compared to untreated controls.

The authors attributed these effects to quercetin’s direct interaction with DNA and its activation of the mitochondrial pathway of apoptosis, and suggested quercetin’s potential use as a cancer therapy adjunct deserves further exploration.

More recent research27 in the journal Molecules also highlights quercetin’s epigenetic influence and ability to:

  • Interact with cell-signaling pathways
  • Modulate gene expression
  • Influence the activity of transcription factors
  • Modulate microRNAs

MicroRNAs used to be considered “junk” DNA. Far from being useless, research has now revealed that “junk” DNA is actually microRNA and plays a crucial role in regulating genes that make the proteins that build your body.

The microRNA function as “on/off” switches for the genes. Depending on the microRNA input, a single gene can code for any of more than 200 protein products. Quercetin’s ability to module microRNA may also help explain its cytotoxic effects, and why it appears to improve cancer survival (at least in mice).

Quercetin Is a Powerful Antiviral

As mentioned, one of the most well-studied attributes of quercetin is its antiviral capacity, which have been attributed to three main mechanisms of action:

  1. Inhibiting the virus’ ability to infect cells
  2. Inhibiting replication of already infected cells
  3. Reducing infected cells’ resistance to treatment with antiviral medication

For example, research28 funded by the U.S. Department of Defense, published in 2007, found it lowers your risk of viral illness and boosts mental performance following extreme physical stress, which might otherwise undermine your immune function and render you more susceptible to infections.

Here, cyclists who received a daily dose of 1,000 mg of quercetin in combination with vitamin C (which enhances plasma quercetin levels29,30) and niacin (to improve absorption) for five weeks were significantly less likely to contract a viral illness after bicycling three hours a day for three consecutive days, compared to untreated controls. While 45% of the placebo group got sick, only 5% of the treatment group did.

In another study31 funded by the U.S. Defense Advanced Research Projects Agency (DARPA), published in 2008, animals treated with quercetin were challenged with a highly pathogenic H1N1 influenza virus. Again, the treatment group had significantly lower morbidity and mortality than the placebo group. A number of other studies have also confirmed quercetin’s effectiveness against a variety of viruses, including the following:

A 1985 study found quercetin inhibits infectivity and replication of herpes simplex virus type 1, polio-virus type 1, parainfluenza virus type 3 and respiratory syncytial virus.32
A 2010 animal study found that quercetin inhibits both influenza A and B viruses. Two other important discoveries were made. Firstly, the viruses were unable to develop resistance to quercetin, and secondly, when used concomitant with antiviral drugs (amantadine or oseltamivir), the effect was significantly amplified — and it prevented drug-resistance from developing.33
A 2004 animal study investigating quercetin’s effect on influenza used a strain of the H3N2 virus. According to the authors:34

“During influenza virus infection, there is ‘oxidative stress.’ Because quercetin restored the concentrations of many antioxidants, it is proposed that it may be useful as a drug in protecting the lung from the deleterious effects of oxygen derived free radicals released during influenza virus infection.”

Another 2016 study found quercetin offered protection against influenza A virus H1N1 by modulating protein expression. More specifically, the regulation of heat shock proteins, fibronectin 1 and prohibitin was instrumental in reducing viral replication.35
A third study published in 2016 found quercetin inhibited a wide spectrum of influenza strains, including H1N1, H3N2 and H5N1. According to the authors, “This study indicates that quercetin showing inhibitory activity in the early stage of influenza infection provides a future therapeutic option to develop effective, safe and affordable natural products for the treatment and prophylaxis of [influenza A viruses] infections.”36
In 2014, researchers noted that quercetin appears to be “a promising treatment for the common cold,” caused by the rhinovirus, adding that “Quercetin has been shown to reduce viral internalization and replication in vitro, and viral load, lung inflammation and airways hyper-responsiveness in vivo.”37

By attenuating oxidative damage, it also lowers your risk of secondary bacterial infections, which is actually the primary cause of influenza-related deaths. Importantly, quercetin increases mitochondrial biogenesis in skeletal muscle, which suggests part of its antiviral effects are due to enhanced mitochondrial antiviral signaling.

A 2016 animal study38 found quercetin inhibited mouse dengue virus and hepatitis virus. Other studies have confirmed quercetin’s power to inhibit both hepatitis B39 and C40 infection.
Most recently, a March 2020 study41 in the Microbial Pathogenesis journal found quercetin “provides comprehensive protection against Streptococcus pneumoniae infection,” both in vitro and in vivo, primarily by neutralizing pneumolysin (PLY),42 one of the toxins released from pneumococci that encourages S. pneumoniae infection to blossom in the first place. As reported by the authors in Microbial Pathogenesis:

“The results indicated that quercetin significantly reduced PLY-induced hemolytic activity and cytotoxicity via repressing the formation of oligomers.

In addition, treatment with quercetin can reduce PLY-mediated cell injury, improve the survival rate of mice infected with a lethal dose of S. pneumoniae, alleviate the pathological damage of lung tissue and inhibit the release of cytokines (IL-1β and TNF-α) in bronchoalveolar lavage fluid.

Considering the importance of these events in antimicrobial resistant S. pneumoniae pathogenesis, our results indicated that quercetin may be a novel potential drug candidate for the treatment of clinical pneumococcal infections.”

Quercetin Combats Inflammation and Boosts Immunity

Aside from its antiviral activity, quercetin is also known for boosting immunity and combating inflammation. As noted in a 2016 study43 in the journal Nutrients, mechanisms of action include (but is not limited to) the inhibition of:44

Lipopolysaccharide (LPS)-induced tumor necrosis factor α (TNF-α) production in macrophages. TNF-α is a cytokine involved in systemic inflammation, secreted by activated macrophages, a type of immune cell that digests foreign substances, microbes and other harmful or damaged components

LPS-induced mRNA levels of TNF-α and interleukin (IL)-1α in glial cells, which results in “diminished apoptotic neuronal cell death”

The production of inflammation-producing enzymes

Calcium influx into the cell, which in turn inhibits:

Pro-inflammatory cytokine release

Histamine and serotonin release from intestinal mast cells release45

According to this paper, quercetin also stabilizes mast cells, has cytoprotective activity in the gastrointestinal tract, and “a direct regulatory effect on basic functional properties of immune cells,” which allows it to inhibit “a huge panoply of molecular targets in the micromolar concentration range, either by down-regulating or suppressing many inflammatory pathways and functions.”46

Quercetin May Be a Useful Supplement for Many

Considering its wide-ranging benefits, quercetin may be a useful supplement for many, either acutely or more long-term. It’s one of the supplements I recommend keeping in your medicine chest for times when you feel you’re “coming down” with something, be it the common cold or influenza.

If you’re prone to colds and flu, you could consider taking it for a couple of months before cold and flu season hits to boost your immune system. More long-term, it appears useful for those with metabolic syndrome, although it would be foolish to rely on any given supplement without also addressing more fundamental strategies such as diet and exercise.

As explained in my 2015 interview with Dr. Robert Lustig, sugar has been shown to be a causative factor in insulin resistance, which is a hallmark of metabolic syndrome and a risk factor for virtually all chronic disease.

If you have one or more of the conditions that make up metabolic syndrome, you’d be wise to limit your total sugar consumption to 15 grams per day. If you’re healthy, and want to stay that way, your daily sugar limit would be around 25 grams. You can learn more about this and related treatment strategies in “Vitamin D Can Significantly Lower Your Risk of Metabolic Syndrome.”

– Sources and References

Glaucoma

Written by Brenton Wight, Health Researcher, LeanMachine
Copyright © 1999-2020 Brenton Wight, LeanMachine
Updated 8th February 2020

Over 60 million people in the world have glaucoma, but only 30 million know they have it as there are no warning signs.
High intra-ocular pressure causes destruction of retinal ganglion cells, leading to vision loss.
Cataracts are the leading cause of blindness and Glaucoma is second.
There is no cure for glaucoma. Treatments focus on reducing intra-ocular pressure, but this does not always prevent further degradation.
High risk groups:

  • Those over 60
  • Those with a family history
  • Diabetics
  • Those who are severely nearsighted
  • Those with light colored eyes. Grey or blue eyes have the highest risk, brown the least
  • Those with increased IOP (intra-ocular pressure)
  • Those with compromised blood flow to the optic nerve
  • Those living with air pollution

What is Glaucoma?

In wide angle glaucoma, the most common form, changes in the trabecular meshwork prevent the aqueous liquid from draining correctly, resulting in an increase in the pressure (inta-ocular pressure) inside the eye.
image trabecular meshwork
The trabecular meshwork is an area around the base of the cornea, responsible for draining the aqueous humor (the liquid in the eye).
The increase in pressure causes destruction of retinal ganglion cells that form part of the optic nerve, resulting in peripheral vision loss, i.e. less vision in the extreme left, right, high and low fields, while the central vision remains relatively intact until the progression of vision loss in the extremities slowly creeps toward the centre of vision.
As glaucoma is more common as we age, and AMD (Age-related Macular Degeneration) is also more common as we age, and affects the central vision, we must look after the health of our eyes to retain as much vision as possible.
In my upcoming article on Macular eye disease, I will discuss the fact that Age-related Macular Degeneration has NOTHING to do with age, but many other factors such as taking aspirin, which increases the effect of blood leakage in the macular area of the retina, compounding the degeneration.
We must look at both conditions, as if we lose central as well as extremities vision, hope for retaining any eyesight is poor.

Cause of Glacoma

Doctors cannot explain why some people get glaucoma and others do not, even if their intra-ocular pressure is raised.
Mitochrondrial dysfunction appears to be the main cause, according to recent studies on glaucoma-prone mice, where glaucoma progression was halted by high doses of Niacin (Vitamin B3), or in particular, by NAD+ which is a derivative of B3. NAD (Nicotinamide adenine dinucleotide) exists in the body in two forms, the oxidized form NAD+ and reduced form NADH. As we age, we produce less and less NAD, which explains increasing risk for glaucoma as well as many other age-related conditions. Seniors have only half the mitochondria of young people.
The mouse studies used a very high dose of Vitamin B3, equivalent to a human taking 40 grams. A typical high-dose Niacin is low in cost and good insurance, improving cardiovascular health as well.
Even better is NADH which is more expensive, but many times more effective.
Also, mitochondrial function can be improved with PQQ, (Pyrroloquinoline Quinine).
A recent study on air pollution:
“The more polluted the air, the higher the risk is that those who live in that area will develop glaucoma”, claims a new study from the UK, published in the journal Investigative Ophthalmology and Visual Science. Researchers found that when the amount of fine particulate matter (FPM, particles 2.5 microns or less in diameter, also called PM 2.5) was higher, the rate of self-reported glaucoma was increased by at least 6%, in contrast to the areas with the least air pollution.

If we ask our Optometrist if there is any food or supplement that can help ward off glaucoma, they will usually say “There is nothing you can do. Take your eye drops, and prepare for surgery.”
Yet, their own web site contains the study info:www.optometry.org.au/blog-news/2017/3/6/vitamin-could-stop-glaucoma/
Could it be that they do not want to lose patients? Why not advise everyone that a daily dose of Vitamin B3 has no side effects and may just stop us from going blind!

See studies below on NADH.

This is not surprising to LeanMachine. I have been advising people for years that most age and lifestyle diseases are caused by mitochondrial dysfunction. Cancer research has all been about genetics, but it is the mitochondria that produces a chemical that produces apoptosis, the programmed cell death of an unhealthy cell. Without healthy mitochondria, we are at a higher risk for cancer, as we need the mitochondria to destroy sick cells before the cancer gets a foothold.
Mitochondria are the energy-producing organelles inside the cytoplasm of every living cell, producing ATP (Adenosine Triphosphate) which we need for everything we do.
As babies, each cell in our body has over 2,000 mitochondria, inherited only from our mother. Some cells requiring more energy have more mitochondria, like heart muscle cells, having around 5,000 mitochondria. At senior age, we only have a few hundred. Exercise increases mitochondria, there is a good reason to get off the couch.

Types of Glaucoma

  • Open Angle (chronic) Glaucoma – the most common type where aqueous fluid drains too slowly from aging of the drainage channel, causing pressure to build inside the eye. Younger people can also get this type. People do not notice vision changes at first because the sharpness of central vision is retained until late stages
  • Normal Tension Glaucoma – also called Low Tension or Normal Pressure Glaucoma. Not related to high pressure, but where the optic nerve is damaged even at normal pressure, or reduced blood supply to the optic nerve. Symptoms include migraine headaches, cold hands and feet, low blood pressure or other blood vessel problems. Those of Japanese descent have a higher risk
  • Acute Angle Closure Glaucoma – where the eye drainage becomes blocked, resulting in a sudden rise in pressure requiring emergency medical care. Symptoms can include blurred vision, severe headaches, eye pain, nausea, vomiting, rainbow-like halos seen around bright lights. Sometimes there are no symptoms. Higher risk for those of Asian or Native American descent
  • Angle Recession Glaucoma – Caused by trauma (injury) to the eye, which allows debris in the eye to gradually block drainage channels, raising the pressure. If treated early, vision can be saved
  • Primary Congenital Glaucoma – 1 in 10,000 babies are born with this hereditary condition. Family history with both parents increases likelihood, but often there is no family history on either side. If the first and second child have it, later children have very high risk. Boys have double the risk as girls. Sometimes affects one eye, but most often affects both. Untreated, this is a major cause of blindness in children. When treated before age 3, eyesight is normally saved. Symptoms include:
    1. Baby closes eyelids as if trying to protect the eye
    2. Baby seems overly sensitive to light
    3. Baby tears up more than normal
    It is imperative to check these warning signs in all infants
  • Secondary Glaucoma – Result of another eye condition such as inflammation, trauma, tumour, uveitis

Other Eye Disease

Many other conditions affect sight, and I will discuss these later in separate articles. Of course, it is quite possible to have more than one condition, so early diagnosis is essential so we are more likely to be dealing with the first condition without confusing treatment with two or more conditions.
Here are a few of the most common:

  • Diabetic Retinopathy affects blood vessels in the retina, and is the most common cause of vision loss among diabetics.
  • Macular Degeneration affects blood vessels in the visual centre (Macula) of the eye. There are wet and dry types.
  • Cataracts where the lens gradually becomes opaque
  • CMV Retinitis an infection of the retina, often affecting thise with poor immunity or with AIDS
  • Diabetic Macular Oedema caused by fluid accumulation in the macula causing severe blurred vision
  • Retinal Detachment the retina separates from the nerve tissue and blood supply underneath it
  • Uveitis is inflammation of one or more of the uvea, the nerve tissue, and/or blood supply underneath. Common with Sarcoidosis

Diagnosis

Typical Eye ChartEveryone should get an annual eye check. In some people, an astute eye doctor can see by the shape of the eye if a person is at high risk, even before they have high pressure or symptoms.
Most people are first checked by an optometrist, and when a problem is found they are normally referred to an ophthalmologist.
The Standard Eye Test: First, after a quick eye chart test, with and without glasses, amblyopia (“lazy eye”) is tested by covering one eye and looking for movement in the other eye, also ocular motility testing to determine how well the eyes follow a moving object, and stereopsis or depth perception.
Then a refraction test checks the degree of hyperopia (farsightedness), myopia (nearsightedness), astigmatism and presbyopia to determine a prescription of any eye-glasses required.
Eye drops are then used to enlarge the pupils and allow better scrutiny of the inner eye.
Warning: These drops can last 4 to 6 hours, and when the patient ventures out into bright light, the pupils cannot respond immediately by reducing the pupil size, so glare and blurred vision can make driving or other activities dangerous, but everyone has a different reaction, and sun glasses are a must.
The doctor uses a “slit lamp” and checks the eyelids, cornea, conjunctiva, iris, and lens. Conditions are checked for retinal detachment, dry eye, blocked tear ducts, drainage problems, cataracts, macular degeneration, corneal ulcers, diabetic retinopathy and other eye disease.
The retina is examined and usually retina photographs are taken for reference in future tests to check for any change.
Typical Retina Photograph
The glaucoma tests:
Eye stain drops are used to check drainage.
Eye pressure is tested using either:
1. NCT (non-contact tonometry) or “puff-of-air” test which measures pressure.
2. Yellow numbing drops are usually used which glow when exposed to blue light. An applanation tonometer then touches the eye surface to measure the intra-ocular pressure.
These procedures are painless, the only feeling may be the machine tickling the eyelashes. Results can vary between these methods and different calibration of instruments, so it is advised to go to the same practice every time, and ask which type of equipmemt is being used, and note the results. A statement such as “Your pressures are fine” is not enough. We need actual numbers so we can compare results over time, and take dietary and other steps to halt any rising pressures before having to resort to surgical treatment.
visual field test is used to determine the field of vision. The patient sits in front of a dished screen with one eye covered, and the other eye focused on a black dot in the centre. The patient then clicks a button when a light spot is repeatedly presented in different areas of peripheral vision.
Typical Field Test
The results are plotted on a graph for each eye which shows areas of lost vision such as the black areas in this plotted image of advanced glaucoma:
Typical Advanced Glaucoma Eye Plot
See actual improvement capable in Glaucoma patients near the bottom of this article.

Colour blindness is normally checked using the Ishihara Color Vision Test booklet, each page containing a circular pattern comprising many dots of various colors, brightness and sizes, making up a single digit number. The full test contains 38 fifferent pages, but a basic test will only involve 14 or 24 different pages. A colour-blind person will see no number, or a different number in this test. Any problems in colour blindness may indicate a health problem such as glaucoma, MS (multiple sclerosis), diabetic retinopathy, macular edema and other disorders, as well as color vision issues caused by long-term use of some prescription medications.
For colour-blind people, specially tinted glasses can improve the distinguishment and vividness of various colours as a vision aid.
The retina has cone photoreceptors, and the red and green cones are often most affected, causing “red-green colour blindness”.

Treatment

Medication helps by either reducing the production and inflow of aqueous fluid into the eye, or by increasing the outflow pathways to allow aqueous fluid to drain more effectively.
Sometimes oral medication is used, but is generally limited in effectiveness, and any improvement is lost in a short time.
Eye drops are usually the first line of treatment in newly diagnosed glaucoma.
Hint: When instilling eye drops, tilt the head backward. Use a finger placed just below the lower lid, pulling down to form a pocket. Look up and squeeze one drop into the pocket in your lower lid. Do not blink. Press on the inside corner of your closed eyes using the index finger and thumb for 2 or 3 minutes to prevent drops from draining into the throat. Wipe excess from the eye. Do not touch the tip of the bottle onto the eye or face. If hands shake, approach the eye from the side, resting the hand on the face to steady the bottle.
Commonly prescribed eye drops for glaucoma:
1. Prostaglandin analogs such as Xalatan® (latanoprost), Lumigan® (bimatoprost), Travatan Z® (Travoprost), and Zioptan™ (tafluprost) and Vyzulta™ (latanoprostene bunod) are typically used. They are used for increasing the outflow of eye fluid.
Side effects include stinging, burning, feeling as if something is in the eye, dry eyes, watering eyes, temporary unstable vision, dizziness, droopy eyelids, sunken eyes, change in the colour of the iris, eyelid, or white of the eye, vision changes, conjunctivitis (pinkeye), sensitivity to light and lengthening and curling of the eyelashes.
Often prescribed as Azarga (combination of brinzolamide and timolol) but can cause corneal erosion long-term as well as other side effects as above.

2. Beta-blockers such as Timolol (Timoptic XE, Istalol) and Betoptic S work by decreasing aqueous fluid production in the eye. Beta-blockers were once the first-line treatment of glaucoma, but just like Beta-blockers prescribed for blood pressure, have nasty side effects but are still sometimes prescribed in combination with prostaglandins.
Side effects include slowing of heart rate, heart problems, lung problems such as emphysema, diabetes, depression, stinging or discomfort of the eye, watery, dry, itchy or red eyes, blurred vision, feeling as if something is in the eye, crusting of eyelashes, headache, trouble sleeping or dizziness.

3. Alpha adrenergic agonists such as brimonidine tartrate (Alphagan®P), Iopidine®, Apraclonidine) work by decreasing production of aqueous fluid and increase drainage. Alphagan P includes a purite preservative, breaking down into natural components of tears, so may be better tolerated in those allergic to preservatives in other eye drops.
Side effects include fast or pounding heartbeats, persistent headache, eye pain, puffiness or swelling, extreme sensitivity to light, vision changes, itching, redness, burning, stinging, feeling like something is in the eye, blurred vision, redness of the eye or eyelid, nausea, upset stomach, dizziness, muscle pain, dry nose or mouth, drowsiness, insomnia or unusual or unpleasant taste in the mouth.

4. Carbonic anhydrase inhibitors (CAI’s) such as dorzolamide (Trusopt®) and brinzolamide (Azopt®) eye drops, as well as pills acetazolamide (Diamox) and methazolamide (Neptazane®). They reduce eye pressure by lowering production of aqueous fluid.
Side effects include shortness of breath, trouble breathing, unusual tiredness or weakness, blood in urine, difficult urination, depression, lower back pain, pain or burning while urinating, sudden decrease in amount of urine, bloody or black, tarry stools, clumsiness or unsteadiness, convulsions (seizures), darkening of urine, fever, hives, skin itching, skin rash, skin sores, pale stools, tinnitus (ringing or buzzing in the ears), sore throat, trembling, unusual bruising or bleeding, yellow eyes or skin.

5. Rho-Kinase (ROCK) inhibitors such as netarsudil (Rhopressa®) increase drainage of intra-ocular fluid. Originally studied for anti-erectile dysfunction, anti-hypertension, and tumor metastasis inhibition, using the same pathway as statins (with potentially similar side effects). Recently approved by the FDA as a glaucoma drug, available in USA since April 2018.
Side effects include conjunctival hyperemia, cornea verticillata and small conjunctival hemorrhages. More side effects will probably be known as it becomes more widely used.

Various combinations of all of the above are available under many different brand names. All have side effects, but there must be a balance between saving sight and dealing with sometimes serious side effects.

Various forms of laser surgery and/or surgery to create a “bleb” or artificial drainage system are used to replace the trabecular meshwork, reducing intra-ocular pressure.
Doctors say that even with surgical intervention, there is no permanent cure, and surgical procedures at best only slow down the progression of the disease.

One way to prevent or delay glaucoma is to reduce blood pressure naturally by consuming a healthy diet and reducing any extra body fat.
Low blood pressure sometimes (but not always) relates to lower intra-ocular pressure.
The same things that cause high blood pressure – trans fats (margarine, canola oil etc), sugar and high GI carbohydrates, will often also cause high eye pressure.
Do NOT be taken in by statin drugs – designed to lower cholesterol. Cholesterol is NOT the evil it is made out to be, in fact we would die without it. Treating 100 people with statins may prevent one heart attack in one person. Changing to a healthy diet will prevent almost all of the 100 from heart attacks.

Glaucoma NO list

Bad fats
1. Margarine – do not be fooled by unscrupulous advertising from margarine manufacturers who claim that margarine reduces cholesterol. Maybe it does, but cholesterol is not our enemy, only OXIDISED Very Low LDL is bad, and that is the dangerous ingredient in margarine. Alternative: Coconut oil, butter, cold olive oil.
2. Canola oil – heat processed in the manufacture oxidises this fat. Cooking with canola oil oxidises the fat even more. NEVER use canola oil for anything.
Alternative: Coconut oil.
3. Sunflower Oil. Flaxseed oil is a much healthier alternative.
4. Hydrogenated oils of any kind. Common in many low-fat baked goods and other processed foods.

Bad drugs
1. Paracetamol, panadol, acetaminophen, tylenol – different names for the same drug marketed as “safe and effective” but it destroys L-Glutathione, the body’s own master antioxidant. Alternatives for pain:
(a) MSM – primarily for joint pain but helps reduce the sensation of any pain.
(b) Bacopa – primarily for slight blood thinning and higher brain function, but also helps with pain.
2. Statins – cholesterol lowering drugs that increase risk of diabetes, clobber our Vitamin D, cause muscle pain and kidney disease, and on average will slightly reduce risk of a heart attack but increase death risk from all other causes, so most people taking statins will not live one day longer, and have a poor quality of life.

Glaucoma Diet

Diet will not cure Glaucoma, but will reduce risk, slow degradation and delay surgery.
Natural methods aim to reduce IOP, increase blood flow to the eye, and lower oxidative stress, just like traditional drug methods.
We can lower glaucoma risk by eating more fresh vegetables and fruits containing Vitamin A, Vitamin C and Lutein, foods high in carotenoid antioxidants such as green leafy vegetables and other green or yellow vegetables. Cooked kale and cooked spinach are best, also egg yolks.
A study showed that women who ate 3 or more daily servings of fruits and fruit juices reduced glaucoma risk by 79% compared to those who consumed less than 1 serving per day.
Those people with high intake of vitamin C levels reduced risk by 70%, while high vitamin A reduced risk by 63%, and alpha-carotene by 54%.
However, not every vegetable or fruit works as well. These foods are proven to cut glaucoma risk:

  • Kale, Cabbage, Broccoli, Collard Greens
    The NIH study showed that 3 or more daily servings of general vegetables had little effect on glaucoma risk, but one serving of kale or collard greens per week reduced glaucoma risk by 57%, and a Harvard study suggested that the benefit is in the high nitrate levels, a precursor for nitric oxide which promotes health of blood vessels. This study (Nurses’ Health Study of 63,893 women, 1984-2012 and Health Professionals Follow-up Study 41,094 men, 1986-2012) found that high dietary leafy greens (= more nitrates) meant 20% to 30% reduction of glaucoma risk. For glaucoma linked to poor blood flow, nitrates reduced risk by 40% to 50%
  • Oranges and Peaches
    The NIH study found that women who consumed more than two servings per week of fresh oranges reduced their risk by 82% while peaches cut their risk by 70%. Whole fresh fruit was best. Juice only gave less benefit, even if they drank it every day. LeanMachine concludes this is due to heat and sugar processing of juice. Fresh peaches were protective, while canned peaches were not. LeanMachine concludes this is due to sugary syrups and heated processing for canned fruit
  • Wild-Caught Salmon
    A British study of glaucoma patients and their healthy siblings, glaucoma patients had lower levels of EPA (eicosapentaenoic) and DHA (docosahexaenoic) fatty acids and total omega-3 long-chain polyunsaturated fatty acids, suggesting that EPA and DHA could improve microcirculation, ocular blood flow and optic neuropathy, which are all associated with glaucoma. Other good sources of EPA and DHA include fatty cold-water fish, e.g. sardines, mackerel, herring and tuna
  • Healthy Fats
    Healthy fats are essential to change the body’s carbohydrate-fueled system into a fat-fueled system where ketones are the primary fuel.
    Best fats are coconut oil, avocados, walnuts, fish oil, krill oil, macadamia oil, butter. Cold-pressed virgin olive oil is healthy when cold (i.e. on a salad) but oxidises when heated
  • Green Tea, Cocoa, Red Wine
    Another study found that flavonoids improved vision and slowed progression of visual field loss in patients with glaucoma and high eye pressure. Read more about flavonoids in my Flavonoids article. Flavonoids are neuroprotective and antioxidant polyphenol compounds found in plants, highest in green tea, red wine and cocoa. LeanMachine says that Cocao (less processing) should be more beneficial than Cocoa
  • Black Currants
    A 24-month trial showed that black currant anthocyanins slowed the visual field deterioration, probably because the black currants improve blood flow in the eye
  • Goji Berries
    An animal study of the goji plant Lycium barbarum L. found it prevented the loss of retinal ganglion cells and neurodegeneration. Benefits found were independent of eye pressure. Animals fed a goji extract nearly totally escaped from pressure-induced loss of retinal ganglion cells. LeanMachine suggests that other high antioxidant foods such as blueberries may also have beneficial effects
  • Eggplant
    In a study of male volunteers, they ate 10 grams of eggplant (Solanum melongena L.) and showed a 25% reduction of intra-ocular pressure, suggesting that eggplant would be beneficial to glaucoma patients

Cooking Methods

Heating food over around 50 degrees Celcius (about the temperature of hot water at the kitchen sink) destroys most of the beneficial enzymes, so salads, fruit or other cold foods should be consumed at at least one meal every day. An organic apple a day definitely keeps the eye doctor away…
When cooking, the safest way is steaming (100 degrees Centigrade). Other cooking methods heat food well over the safety limit of 120 degrees Centigrade. Over 120 degrees, AGEs form (Advanced Glycation End-products) which damage the mitochondria and many other body systems.

Supplements for Glaucoma

While healthy foods will help delay glaucoma, as well as reducing risk of diabetes, cardiovascular disease, Alzheimers, obesity and more, there is often not enough healthy content available due to intensive farming practices, combined with chemical additives in the soil, to give the glaucoma patient enough of the correct nutrition.
Lean Machine recommends a combination of a healthy diet, supplements and sun exposure for optimum nutrition.
Oxidative stress is a major factor in progression of glaucoma, so antioxidants are important.
Various vitamins and minerals have been proven to reduce glaucoma symptoms, but eye doctors seldom pass on this information.
Supplements do not make up for a bad diet. Supplements often only supply a single important extract, but whole, natural foods contain fibre, enzymes and many other important compounds, so LeanMachine recommends a combination of both.
The following are the main supplements LeanMachine recommends for glaucoma patients:

In addition, foods improving mitochondria are:
1. Proteins such as fish, nuts, seeds, beans, lentils, eggs that support glutathione and other amino acids which protect the mitochondria.
2. Antioxidants – colourful vegetables, fresh fruit, herbs, spices. Best spices are cloves and turmeric.

Supplements for Glutathione include:

Glaucoma can get better

Mrs LeanMachine was diagnosed with an aggressive form of Glaucoma at age 48, which is much younger than most, and blindness often follows in 5 to 10 years. However, due to a reasonably healthy lifestyle, degradation was slow, but consistent.
Right Eye scan. Black areas represent loss of vision, grey represent partial loss.

Right eye scan, January 2014
Right Scan January 2014, age 68 Right Scan January 2020, age 74

Her Opthalmologist has never seen improvement, especially this much improvement in any Glaucoma patient.
The main change in the last few years has been an array of Vitamins, Minerals and Nutrients, and a healthy diet, free from all hydrogenated oils and bad fats (e.g. Margarine, Canola Oil).
Another victory for LeanMachine! In addition, Mrs LeanMachine is now free from diabetes, blood pressure, never gets a cold or flu, has no prescription medication, no eye drops, no vaccinations. In fact, the biggest improvement was seen since she stopped taking the prescribed eye drops (because of side effects).

NADH Studies
Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging (2013) – http://jmp.sh/s1CKUez – this article (more technical/scientific) was the catalyst for the NAD+ research momentum which presently exists

NAD – Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice (2016) http://jmp.sh/6GZMwPq – the infographic on the cover page pretty much sums up the effects in humans too

NAD – Short-term administration of Nicotinamide Mononucleotide preserves cardiac mitochondrial homeostasis and prevents heart failure (2017) http://jmp.sh/yHKH355

NAD – Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice (2016) http://jmp.sh/B4OET23

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice (2016) http://jmp.sh/IlxzSUx

NAD – Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle (2016) http://jmp.sh/XjlgLOV

NAD – Nicotinamide mononucleotide improves energy activity and survival rate in an in vitro model of Parkinson’s disease (2014) http://jmp.sh/gnAHrz3

NAD – Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice (2011) http://jmp.sh/UlRkYGD

NAD+ in aging, metabolism, and neurodegeneration (2015) http://jmp.sh/pkSKzz3

NAD – Exogenous NAD+ administration significantly protects against myocardial ischemia-reperfusion injury in rat model (2016) http://jmp.sh/ufBDDWA

NAD – Prevention of Traumatic Brain Injury-Induced Neuron Death by Intranasal Delivery of Nicotinamide Adenine Dinucleotide (2012) http://jmp.sh/iGqzbgo

NAD+ controls neural stem cell fate in the aging brain (2014) http://jmp.sh/tlIvnhg

NAD+ Deficiency in Age-Related Mitochondrial Dysfunction (2014) http://jmp.sh/DGwKD45

NAD – The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity (2012) http://jmp.sh/vTHsM1r

NAD – Nicotinamide mononucleotide inhibits post-ischemic NAD+ degradation and dramatically ameliorates brain damage following global cerebral ischemia (2016) http://jmp.sh/iqJczKC

NAD – Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer’s disease-relevant murine model (2015) http://jmp.sh/8oIdCfo

NAD – Nicotinamide Mononucleotide, an Intermediate of NAD+ Synthesis, Protects the Heart from Ischemia and Reperfusion (2014) http://jmp.sh/WwBFWdR

NAD – Restoration of Mitochondrial NAD+ Levels Delays Stem Cell Senescence and Facilitates Reprogramming of Aged Somatic Cells (2016) http://jmp.sh/L3dXEm1

NAD – Nicotinamide Mononucleotide, an NAD+ Precursor, Rescues Age-Associated Susceptibility to Acute Kidney Injury [was ‘AKI’] in a Sirtuin 1–Dependent Manner (2017) http://jmp.sh/cWda60C

NAD – NAD replenishment with nicotinamide mononucleotide protects blood–brain barrier integrity and attenuates delayed tissue plasminogen activator-induced haemorrhagic transformation after cerebral ischaemia (2017) http://jmp.sh/mkmiXxP

NAD – Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease [2017] http://jmp.sh/GhDCkte

LeanMachine Health Supplements

Disclaimer

LeanMachine is not a doctor, and everyone should consult with their own health professional before taking any product to ensure there is no conflict with existing prescription medication.
LeanMachine has been researching nutrition and health since 2010 and has completed many relevant studies.

Updated 29th January 2020, Copyright © 1999-2020 Brenton Wight and BJ & HJ Wight trading as Lean Machine abn 55293601285

Iron Overload Destroys Mitochondria and Sabotages Health


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2020/01/15/iron-overload-destroys-mitochondria.aspx

Analysis by Dr. Joseph Mercola Fact Checked image
January 15, 2020
iron overload destroys mitochondria

STORY AT-A-GLANCE

  • Iron is essential for life as it transfers oxygen to your tissues. Hemoglobin, the protein in your red blood cells, contains iron at its core, which reversibly binds to oxygen and supplies your tissues with it
  • Without proper oxygenation, your cells quickly start dying. However, excess iron can also cause severe problems by encouraging oxidation and tissue damage
  • Common health problems associated with elevated iron levels include cirrhosis, cancer, hepatitis C, gouty arthritis, arrhythmia, cardiovascular disease, Type 2 diabetes, Alzheimer’s and more
  • Recent research shows excessive iron damages mitochondrial function and impairs your heart function by inducing the death of muscle cells in your heart
  • Your iron level can be easily determined with a serum ferritin test. I believe this is one of the most important tests that everyone should have done on a regular basis as part of a preventive, proactive health screen

Iron is necessary for life as it essential to transfer oxygen into your tissues. Hemoglobin, the protein in your red blood cells that contains iron at its core, reversibly binds to oxygen and supplies your tissues with it. Without proper oxygenation, your cells quickly start dying.

Iron is also a key component of various proteins and enzymes, and is involved in energy production, immune function, metabolism and endocrine function. For these reasons, low iron (anemia) can cause significant health problems.

However, what many don’t realize is that excess iron is actually more common than too little, and iron overload can be even more problematic, as detailed in “Why Managing Your Iron Level Is Crucial to Your Health,” which features my interview with Gerry Koenig, former chairman of the Iron Disorders Institute and the Hemochromatosis Foundation.

Because your body has a limited capacity to excrete iron, it can easily build up in organs like your liver, heart and pancreas. This is dangerous because iron is a potent oxidizer that can damage your tissues and contribute to a variety of health problems, including but not limited to:

Cirrhosis1 Cancer, including bowel,2 liver3 and lung cancer4 — Elevated ferritin is associated with a 2.9 times higher risk of death from cancer5 and blood donors have been shown to have a lower likelihood of developing certain cancers than nondonors6,7
Hepatitis C8 — As noted in a 2007 paper,9 even “mild or moderate increase of iron stores appears to have significant clinical relevance” in this and other conditions Gouty arthritis10
Cardiac arrhythmia11 Cardiovascular disease12
Type 2 diabetes13 and metabolic syndrome — Elevated ferritin has been linked to dysfunctional glucose metabolism,14 raising the risk of diabetes fivefold in men and fourfold in women, a magnitude of correlation similar to that of obesity.15

High ferritin also doubles your risk of metabolic syndrome,16 a condition associated with an increased risk of high blood pressure, liver disease and heart disease

Alzheimer’s disease17

Iron Overload Impairs Mitochondrial Function

Iron causes significant harm primarily by catalyzing a reaction within the inner mitochondrial membrane. When iron reacts with hydrogen peroxide, hydroxyl free radicals are formed.

These are among the most damaging free radicals known, causing severe mitochondrial dysfunction, which in turn is at the heart of most chronic degenerative diseases. The hydroxyl free radicals are an oxidative stress that will also damage your cell membranes, stem cells, protein and DNA.

In addition to all this damage, recent research18 shows excessive iron also promotes apoptosis and ferroptosis in cardiomyocytes. Apoptosis is the programmed cell death of diseased and worn-out cells, and as the name implies, ferroptosis refers to cell death that is dependent on and regulated by iron specifically.19

Cardiomyocytes are muscle cells in your heart that generate and control the rhythmic contractions in your heart, thus allowing it to maintain a healthy rhythm.20 In short, this tells us that excess iron has the ability to impair your heart function by inducing mitochondrial abnormalities and the death of muscle cells in your heart.

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How Iron Overload Affects Your Risk of Alzheimer’s Disease

Aside from raising your risk of heart-related problems, iron overload is also of particular concern in Alzheimer’s disease,21,22,23 the prevalence of which has dramatically risen in recent decades.

According to research24,25 published in 2018, buildup of iron — which increases oxidative stress and has a type of “rusting effect” in your brain — is common in most Alzheimer’s patients. As noted by the authors:26

“In the presence of the pathological hallmarks of [Alzheimer’s disease], iron is accumulated within and around the amyloid-beta plaques and neurofibrillary tangles, mostly as ferrihydrite inside ferritin, hemosiderin and magnetite.

The co-localization of iron with amyloid-beta has been proposed to constitute a major source of toxicity. Indeed, in vitro, amyloid-beta has been shown to convert ferric iron to ferrous iron, which can act as a catalyst for the Fenton reaction to generate toxic free radicals, which in turn result in oxidative stress.”

Other research 27 suggests elevated cerebrospinal fluid iron levels are strongly correlated with the presence of the Alzheimer’s risk allele APOE-e4, and that elevated levels of iron in your brain may actually be the mechanism that makes APOE-e4 a major genetic risk factor for the disease.

A primary focus of conventional treatment so far has been to clear amyloid proteins, but while that approach seems logical, such attempts have met with limited success.

Researchers now suggest clearing out excess iron may be a more effective way to reduce damage and slow or prevent the Alzheimer’s disease process. You can learn more about this in “How Excess Iron Raises Your Risk for Alzheimer’s.”

Iron Dysregulation Is Surprisingly Common

It’s easy to get too much iron as it’s commonly added to most multivitamins. Many processed foods are also fortified with iron. Two servings of fortified breakfast cereal may provide as much as 44 milligrams (mg) of iron in some cases,28 bringing you dangerously close to the upper tolerance limit of 45 mg for adults, and well over the recommended daily allowance, which is a mere 8 mg for men and 18 mg for premenopausal women (i.e., women who still get their monthly period).29

Unfortunately, many doctors don’t understand or appreciate the importance of checking for iron overload. One of the greatest risk factors for iron overload is having a condition called hemochromatosis30 — one of the most prevalent genetic diseases in the U.S. — which impairs your body’s iron regulation, causing you to absorb higher than normal amounts.

The C282Y gene mutation is thought to be responsible for the majority of hemochromatosis cases. It takes two inherited copies of the mutation (one from your mother and one from your father) to cause the disease (and even then, only some people will actually get sick).

More than 30% of Americans are thought to have two copies of this defective gene31 and, according to one study,32 an estimated 40% to 70% of those with two defective C282Y genes will develop clinical evidence of iron overload.

If you have just one copy, you won’t become ill but you will still absorb slightly more iron than the rest of the population,33,34 thus placing you at increased risk for overload and the complications associated with it.

Common Factors That Increase Your Risk of Iron Overload

Virtually all adult men and postmenopausal women are also at risk for iron overload since they do not lose blood on a regular basis. Blood loss is the primary way to lower excess iron, as the body has no active excretion mechanisms. Other potential contributors to high iron levels include:

  • Cooking in iron pots or pans — Cooking acidic foods in these types of pots or pans will elevate iron absorption.
  • Eating processed food products like cereals and white breads fortified with iron — The iron used in these products is inorganic iron, not much different from rust, and it is far more dangerous than the iron in meat.
  • Drinking well water that is high in iron — The key here is to make sure you have some type of iron precipitator and/or a reverse osmosis water filter.
  • Taking multiple vitamins and mineral supplements, as both of these frequently have iron in them.
  • Regularly consuming alcohol, as this will increase the absorption of iron in your diet.

How to Check for and Address Iron Overload

Checking your iron levels is easy and can be done with a simple blood test called a serum ferritin test. I believe this is one of the most important tests that everyone should have done on a regular basis as part of a preventive, proactive health screen. The test measures the carrier molecule of iron, a protein found inside cells called ferritin, which stores the iron. If your ferritin levels are low, it means your iron levels are also low.

The healthy range of serum ferritin lies between 20 and 80 nanograms per milliliter (ng/ml). Below 20 ng/ml is a strong indicator that you are iron deficient, and above 80 ng/ml suggests you have an iron surplus. An ideal range is between 40 and 60 ng/ml.

Please note that many health sites will tell you that “normal” can be much higher than that, but as I discuss with Koenig in the earlier referenced article, levels over 300 ng/ml are particularly toxic and will eventually cause serious damage.

If you have hemochromatosis, or if a serum ferritin blood test reveals elevated iron levels, donating your blood two or three times a year is the safest, most effective and inexpensive remedy. If you have severe overload you may need to do more regular phlebotomies.

If, for some reason, a blood donor center is unable to accept your blood for donation, you can obtain a prescription for therapeutic phlebotomy. At the same time, you’ll also want to avoid consuming excess iron in the form of supplements, in your drinking water (well water), from iron cookware or fortified processed foods.

You can also limit iron absorption by not eating iron-rich foods in combination with vitamin C-rich foods or beverages, as the vitamin C boosts iron absorption. If needed, you could also take a curcumin supplement. Curcumin acts as a potent chelator of iron and can be a useful supplement if your iron is elevated.

GGT Test Is Also Advisable to Rule Out Iron Toxicity

Aside from a serum ferritin test, a gamma-glutamyl transpeptidase (GGT) test can also be used as a screening marker for excess free iron and is a great indicator of your risk for sudden cardiac death, insulin resistance, cardiometabolic disease35 and chronic kidney disease36 as well.

In recent years, scientists have discovered GGT is highly interactive with iron. Low GGT tends to be protective against higher ferritin, so if your GGT is low, you’re largely protected even if your ferritin is a bit higher than ideal.

When both your serum ferritin and GGT are high, you are at significantly increased risk of chronic health problems and early death,37,38 because then you have a combination of free iron (which is highly toxic), and the iron storage to keep that toxicity going.39 That said, even if your ferritin is low, having elevated GGT levels is cause for concern and needs to be addressed.

For this reason, getting a GGT test in addition to a serum ferritin test is advisable to rule out iron toxicity. The ideal level of GGT is below 16 units per liter (U/L) for men and below 9 U/L for women. Above 25 U/L for men and 18 U/L for women, your risk of chronic disease increases significantly.

To lower your GGT level you’ll need to implement strategies that boost glutathione, a potent antioxidant produced in your body, as GGT is inversely related to glutathione. As your GGT level rises, your glutathione goes down. This is in fact part of the equation explaining how elevated GGT harms your health. By elevating your glutathione level, you will lower your GGT.

The amino acid cysteine, found in whey protein, poultry and eggs, plays an important role in your body’s production of glutathione. Red meat, which does not contain cysteine, will tend to raise GGT, as will alcohol, so both should be avoided.40

Certain medications can also raise your GGT. If this is the case, please confer with your doctor to determine whether you might be able to stop the medication or switch to something else. General detoxification is another important component if your GGT is high, as your liver’s job is to remove toxins from your body. The fact that your GGT is elevated means your liver is under stress.

Annual Ferritin Test Is an Important Health Screen

For adults, I strongly recommend getting an annual serum ferritin test to confirm you’re neither too high nor too low. When it comes to iron overload, I believe it can be every bit as dangerous to your health as vitamin D deficiency, and checking your iron status is far more important than your cholesterol.

While a full iron panel that checks serum iron, iron-binding capacity and ferritin can be helpful, you really only need the serum ferritin test, plus the GGT test. Your doctor can write you a prescription for these tests, or you can order them from HealtheIron.com.

Again, if your ferritin is high, the easiest way to lower it is to donate blood two or three times a year. U.S. legislation allows all blood banks to perform therapeutic phlebotomy for hemochromatosis or iron overload. All you need is a doctor’s order.

Also, unless you have a lab-documented iron deficiency, avoid iron-containing multivitamins, iron supplements and mineral supplements that contain iron if your levels are already high.

– Sources and References

Boost energy by renewing your stem cells and regenerating the mitochondria with a natural compound

Reproduced from original article:
www.naturalhealth365.com/nad-stem-cells-energy-3263.html

nad-boost-energy(NaturalHealth365) There’s significant interest surrounding the uses of stem cell infusion therapies, which are offered both in the United States and around the world. Some studies show that infusions of exosomes – which healthy stem cells secrete naturally – may offer some benefits. These exosomes have certain regenerative properties that can work to restore functional cells required for organ viability and tissue maintenance.

However, while many individuals continue to look at the benefits of exosome treatments – which may be out of reach for many people – they often fail to consider some of the approaches you may already be following that can help rejuvenate your existing pools of stem cells. Increasing levels of sirtuins, activating AMPK, and restoring your levels of NAD+ all offer some excellent ways to self-renew the stem cells you already have to help prevent disease and extend lifespan.

Studies uncover the key to boosting your cellular energy

First of all, what is NAD+?  It’s a compound that’s in every cell and it’s essential for the production of cell energy. But recent research shows it does far more.

Many different proteins in your cells require this natural compound to work properly, including sirtuins – cellular guardians that work to protect cells from DNA damage that can result in age-related health issues.  Evidence also shows that sirtuins help replace damaged and old mitochondria with new, healthy mitochondria – the powerhouse of each cell – resulting in enhanced mitochondrial function.

By increasing NAD+ levels, it’s possible to promote AMPK activity, an enzyme that helps boost metabolism and protect against diabetes and obesity.  It also modulates p53, which is a tumor suppressor gene that helps protect against cancer by repairing damaged DNA, and inhibits NF-kB, a type of protein tied to chronic inflammation.

Do NOT ignore the health dangers linked to toxic indoor air.  These chemicals – the ‘off-gassing’ of paints, mattresses, carpets and other home/office building materials – increase your risk of headaches, dementia, heart disease and cancer.

Get the BEST indoor air purification system – at the LOWEST price, exclusively for NaturalHealth365 readers.  I, personally use this system in my home AND office.  Click HERE to order now – before the sale ends.

How do you boost those levels of NAD+?  Studies show that taking a nicotinamide riboside supplement is an easy way to increase levels of this natural compound, since it’s converted to NAD+ within the body. Studies show that taking 300 mg of nicotinamide riboside daily is associated with a 51% increase in NAD+ cellular levels.

Boosting NAD+ levels offer multiple significant health benefits

Increase your NAD+ levels by taking nicotinamide riboside offers a number of significant and well-documented health benefits, including:

  • Increased longevity: Multiple studies show that boosting NAD+ levels helps prolong life
  • Improved brain health: Researchers have found that nicotinamide riboside supplementation helps reverse cognitive deficits and improves memory and may be useful for treating Alzheimer’s disease.
  • Boost in physical performance: In studies done on older man, in just two hours after taking nicotinamide riboside, NAD+ levels increased and they enjoyed improve physical performance and reduced problems with fatigue.
  • Improved cardiovascular health: Research supports the ability of nicotinamide riboside to help protect organs within the cardiovascular system and reduces the risk of heart disease.
  • Lower risk of metabolic disorders and obesity: Increasing NAD+ helps boost the production of sirtuins – which improves metabolism and can help guard against metabolic syndrome, diabetes, and weight gain.
  • Improved sleep: NAD+ has the potential to rebalance circadian rhythms, helping to improve sleep.

Nicotinamide riboside can be taken orally and is highly bioavailable in this form. Regular supplementation with this supplement can boost your NAD+ levels, reducing your risk of age-related health problems and offering many health benefits.

Of course, as we always suggest – especially if you’re feeling very low in energy, talk to your integrative healthcare provider before making any significant changes to your lifestyle.  It’s always good to have help when working on improving your health.

Sources for this article include:

LifeExtension.com
NIH.gov
Springer.com
NIH.gov