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Hawthorn Berries Can Benefit Your Heart, Liver and Skin

The Truth About COVID-19 | A New Book by Dr.Joseph Mercola

Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2021/03/08/hawthorn-berry-health-benefits.aspx

Analysis by Dr. Joseph Mercola    Fact Checked     March 08, 2021

hawthorn berry health benefits

STORY AT-A-GLANCE

  • Hawthorn berries have been used as far back as 659 AD to support heart health. Research demonstrates the extract has anti-atherosclerotic effects and antioxidation, anti-inflammatory and endothelial protective properties
  • The berries have traditionally been used for digestive issues. In animal studies, they have reduced the effects of nonalcoholic fatty liver disease (NAFLD) and improved liver function
  • The antiaging and photoprotective properties may be associated with the high polyphenol content. Hawthorn extract has demonstrated improvement in skin characteristics such as density, roughness and elasticity
  • The plant is native to North America, growing wild and as a cultivated ornamental plant. Although most of the plant is edible, the seeds produce deadly hydrogen cyanide in your intestines

The rich flavonoid content found in hawthorn berries (genus Crataegus) has helped reverse the effects of cardiovascular disease, improve skin and support digestion and liver metabolism.1

Nearly 6 in every 10 adults living in the U.S. have at least one chronic disease and 4 of every 10 have two or more, which are the leading causes of death and disability.2 You can make a difference in your overall health and reduce your risk of many chronic diseases through lifestyle choices. In some cases, you’ll choose to stop something, and in others, you’ll choose to start.

According to the American Heart Association,3 nearly 50% of all adults living in the U.S. are affected by cardiovascular disease. This umbrella term includes several conditions, including heart disease, atherosclerosis, stroke, heart failure, high blood pressure and cardiac arrhythmias.4

Cardiovascular diseases affect the heart and supportive tissues that deliver blood, oxygen and nutrients throughout your body. According to the Centers for Disease Control and Prevention,5 heart disease is the leading cause of death in the U.S. and stroke is No. 5. Atherosclerosis is a significant factor associated with cardiovascular disease.

Yet, there are choices you can make that have an impact on your health, even after chronic diseases have developed. Consuming hawthorn berries or their extract may be one of those choices.

Hawthorn Berries Are Good for Your Heart

The medicinal use of hawthorn berries dates back to 659 AD in China.6 By the early 1800s, doctors in the U.S. were using it to treat heart conditions, including high blood pressure, heart failure and atherosclerosis.7

Modern research studies have found hawthorn berry extract demonstrates anti-atherosclerotic effects that may be related to signaling pathways affecting inflammation and apoptosis.8 Scientists have discovered four principal pathways in which hawthorn berries influence the cardiovascular system.9 These include antioxidation, anti-inflammatory, endothelial protection and lipid-lowering properties.

A review of the literature found the flavones in hawthorn demonstrated the ability to mitigate endothelial impairment following a coronary bypass graft operation. Hawthorn extract has also demonstrated the ability to maintain normal endothelial function in the lab and in vivo.

The extract helps reduce lipid retention and vascular plaque formation. This starts a process that ultimately reduces the production of inflammatory cytokines and reactive oxygen species (ROS). In turn, this helps maintain normal function and protect the vascular system from infiltration of circulating macrophages and monocytes, thus continuing to reduce inflammation.

Several human trials have demonstrated that participants taking hawthorn extract could increase their working capacity and reduce the symptoms of congestive heart failure.10 In one study11 of 952 patients with documented heart failure, researchers found those who received hawthorn as an add-on therapy for two years demonstrated significantly fewer symptoms of congestive heart failure — fatigue, dyspnea and palpitations.

Vascular protection also includes the ability to support calcium signaling activity in the heart and blood vessels.12 Several animal studies have shown that hawthorn acts as a vasodilator,13 including acting to raise levels of nitric oxide.14,15

In one 16-week study16 of individuals with Type 2 diabetes and high blood pressure, participants took 1,200 milligrams (mg) of hawthorn extract each day or a placebo. Those taking the extract demonstrated greater improvements in blood pressure over the placebo group. The researchers reported no interactions with the drugs the patients were already taking and there were only minor health complaints in both groups.

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Liver Metabolism Benefits From Hawthorn Berries

Hawthorn berries also have traditionally been used to treat digestive issues, including constipation. The berries contain fiber that acts as a prebiotic to feed your healthy gut bacteria. In one animal study, those treated with hawthorn extract reduced the transit time of food in the digestive tract.17

In another animal study using rats with stomach ulcers, the extract showed protective effects on the stomach lining similar to those of an anti-ulcer medication.18 Hawthorn extract has also demonstrated the ability to lessen fat accumulation within the liver in animals fed a high-fat diet.

Fat accumulation in the liver that occurs without alcohol use is called nonalcoholic fatty liver disease (NAFLD).19 A more severe form is called nonalcoholic steatohepatitis (NASH), which triggers swelling and permanent damage to the organ.

Liver diseases are emerging as a global health concern, and NAFLD and alcoholic liver disease are the two most common.20 Although there is a wide variation found from country to country, the pooled prevalence globally is 25.24% of the population.

The highest prevalence has been found in the Middle East and South American countries, and the lowest prevalence is found in Africa. In the U.S. and North America, the prevalence is between 21% and 24.7%. In one animal study,21 researchers found that hawthorn leaf flavonoids, the most bioactive extracts found in hawthorn leaves, had a positive influence over diet-induced hepatic steatosis.

They also discovered the supplementation lowered the animals’ body weight and liver weight, and improved serum parameters and liver function. It appeared this was the result of increasing circulating adiponectin levels, which is a hormone involved in the regulation of glucose and fatty acid breakdown.

In addition, it activated AMPK. This led the researchers to conclude that hawthorn leaf extract helps ameliorate “hepatic steatosis by enhancing the adiponectin/AMPK pathway in the liver of HFD [high fat diet] induced NAFLD rats.”22

Antiaging Benefits Include Protection Against Wrinkles

Polyphenols have long been studied for the contribution they make helping to protect your skin from ultraviolet light and modulating skin characteristics. While hawthorn berry is rich in flavonoids, it is highest in proanthocyanidins, oligomeric proanthocyanidin (OPCs) or procyanidolic oligomers (PCOs).23 An analysis of hawthorn extract using high-performance liquid chromatography showed it was also high in epicatechins.24

The combination of chlorogenic acid, proanthocyanidins B2 and epicatechins accounted for 51.4% of the total amount of polyphenols in the fruit. These compounds are strong antioxidants. Like other areas of your body, the connective tissue in your skin is subject to the damaging effects of chronic inflammation and reactive oxygen species.25

Studies have demonstrated the powerful effects that epicatechins and proanthocyanidins have on photoprotection and the structure and function of your skin. One study26 evaluated the effect hawthorn extract has on skin aging triggered by UVB light that increases matrix metalloproteinase (MMP) production and the degradation of collagen.

This combination of damage from UVB light leads to the formation of wrinkles. Using an animal model, the researchers found treatments reversed epidermal thickening and damage caused by UVB light, which “suppressed MMP expression and stimulated the production of type I procollagen.”27 This suggested to the researchers that hawthorn extract may help “prevent UVB radiation-induced skin photoaging.”28

Another review of the literature29 found PCO and quercetin are specific bioflavonoids that are beneficial to connective tissue as they are associated with increased local circulation and promote the development of a strong collagen matrix.

Catechins are also strong antioxidants that have demonstrated anti-inflammatory and antimicrobial properties. In one study30 using green tea polyphenols, researchers engaged 60 women in a 12-week, double-blind, placebo-controlled study. The intervention group drank a beverage with 1,402 mg of total catechins per day.

Their skin structure, function and photoprotection were measured throughout the study. After exposure to a solar simulator, researchers found that those drinking the polyphenol beverage had better oxygen delivery and blood flow to the skin. The structural characteristics of the skin that were positively affected in the experimental group included density, elasticity, roughness and scaling.

What Is Hawthorn Berry?

The hawthorn plant is native to Northern temperate zones and commonly found in North America. It grows wild and is also cultivated as a garden ornamental.31 It’s commonly called a thornapple in reference to the apple-like fruit and thorns that protect the plant. They are sometimes planted as a thorny hedged barrier against livestock.

The plant is a member of the rose family. In the early spring, the plant has white or pink flowers that are followed by small apple-like fruit, which can range in color from red to black. Although the fruit can vary in flavor and texture, depending on the hawthorn plant, they are edible and, as I already mentioned, often used as herbal medicine.

Depending on the species, the plants can grow as a shorter rounded bush or a tree, reaching up to 25 feet tall. You’ll find hawthorn trees at nurseries as either seedlings or grafted trees.32 The plants enjoy full or partial sun and are susceptible to a number of diseases.33

If you decide to plant one in your garden, look for a variety that is disease-resistant. If you’re not using it as a barrier, avoid planting a tree with thorns as the thorns can grow up to 3 inches long. Although the trees don’t need much pruning, it’s wise to remove the suckers that come from the base of the trunk as they increase the size and density of the plant as it ages.

At one time, the hawthorn tree was known as the “bread and cheese tree” since the flowers, berries and leaves are safe to eat and it was a lifesaver during times of famine.34 The berries are also sometimes used to make wine, jam or syrup.

Easy Steps to Add Hawthorn to Your Diet

Hawthorn berries are likely going to be difficult to find at your local grocery store. However, you may find them sold at farmers markets, online or at specialty health food stores. There are several different ways you can incorporate them into your diet. The raw berries have a slightly sweet, yet tart taste and make a great snack.35

However, while the berries are not poisonous, the seeds are. The seeds contain amygdalin, which converts to deadly hydrogen cyanide in your small intestines.36 An adult may tolerate one or two seeds, but even this small amount in a child may be lethal.

You can also find hawthorn tea made with leaves or berries, or you can dry them and make your own tea at home.37 Hawthorn supplements are also available. According to a paper in the Journal of the American College of Cardiology38 from the Foundation Task Force on Clinical Expert Consensus Documents, the minimum effective dose of hawthorn extract for cardiac performance is 300 mg per day.

The authors found that the maximum benefit in most of the trials they reviewed was found after six to eight weeks of taking the supplement. Improved exercise tolerance in individuals with congestive heart failure was demonstrated in several studies they reviewed. The preparation was also found to be “well-tolerated and safe.”39

 

– Sources and References

This Is the Primary Benefit of Niacin (B3)


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2020/11/16/niacin-benefits.aspx
Analysis by Dr. Joseph Mercola      Fact Checked      November 16, 2020

niacin benefits

STORY AT-A-GLANCE

  • Niacin plays an important role in photoprotection from the effect of UV radiation on DNA damage and oxidative stress and helps guard against the rising prevalence of skin cancer
  • Some research has also found long-term benefits from taking niacin that lower your risk of all-cause mortality
  • B vitamins help support your immune system. B3 is a precursor to NAD and may help prevent some of the worst COVID-19 outcomes from cytokine and bradykinin storms
  • Seek to get your B3 from food; high dose supplements may trigger a niacin flush in which your skin will get red and tingle. Although it is irritating, it is harmless

Niacin, also called vitamin B3, is a water-soluble vitamin that is found naturally in foods, is added to processed foods and can be bought as a supplement. Niacin plays a vital role in over 400 enzymes, and one study suggests that a diet rich in niacin could protect your skin against ultraviolet (UV) radiation.1

A severe niacin deficiency called pellagra is ultimately a lethal disease. While it was common in the early 20th century, pellagra is uncommon in industrialized populations where most processed foods are fortified with niacin. Currently, pellagra is limited to people living in poverty whose diets are low in niacin and protein.2

The disease is marked by the four D’s: diarrhea, dermatitis, dementia and death. Symptoms of the condition include a brown discoloration on skin exposed to sunlight, a bright red tongue and vomiting, constipation and/or diarrhea. Neurological symptoms include headache, fatigue, loss of memory and depression.

Without treatment, the disease progresses until a person exhibits paranoid and suicidal behaviors with visual and auditory hallucinations and dies. Although this deficiency is rare in industrialized nations, insufficiency contributes to several disease entities and researchers have found:3

“Benefits of niacin supplementation have been observed in experimental models of cancer, cardiovascular disease, skin health, mental health, and oxidant lung injury.”

Niacin Protects Your Skin From UV Radiation

There are three main forms of niacin, which are dietary precursors to nicotinamide adenine dinucleotide (NAD). These are nicotinamide riboside, nicotinic acid and nicotinamide.4 Researchers in Italy studied skin cells from nonmelanoma skin cancers and treated them with different doses of nicotinamide for 48, 24 and 18 hours, after which they were exposed to UV light.

The lab studies showed the cells that were pretreated with nicotinamide were protected from oxidative stress, including damage to DNA from ultraviolet rays. In addition, the data showed niacin reduced local inflammation and the production of reactive oxygen species. Laura Camillo participated in the study and commented in a press release:5

“Our study indicates that increasing the consumption of vitamin B3, which is readily available in the daily diet, will protect the skin from some of the effects of UV exposure, potentially reducing the incidence of non-melanoma skin cancers. However, the protective effect of vitamin B3 is short-acting, so it should be consumed no later than 24 to 48 hours before sun exposure.”

The current lab study supported data from past studies demonstrating similar results. In an animal model, nicotinamide helps prevent photocarcinogenesis and protected the skin against UVA and UVB light.6 Researchers also tested nicotinamide supplements twice-daily in a human trial with people who had actinic keratosis, a precursor to skin cancer.

The nicotinamide supplements reduced the actinic keratosis by 35% relative to the placebo used in the study when it was measured at two and four months. The results were presented at the 41st European Society for Dermatological Research Annual Meeting 2011.

In a paper published in American Health & Drug Benefits, the author reported on one study investigating the use of oral nicotinamide in people who were at high risk for skin cancer.7 The data showed the supplement reduced the rate of new diagnosis of basal cell and squamous cell carcinoma after one year by 23% when the results were compared against a placebo.

Niacin also lowered the risk the participant would develop actinic keratosis. It was estimated the use of this inexpensive supplement could reduce health care costs by approximately $4.8 million each year. The investigators stressed the results were in individuals who had been diagnosed with skin cancer in the past and may not apply to other populations.

In addition, the researchers believe vitamin B3 could be used as a preventive strategy and not treatment. The lead investigator from the University of Sydney also warned the prevention did not take the place of routine care and skin examinations, commenting:8

“This form of prevention is safe and inexpensive, costing around $10 per month, and it is widely available. It is ready to go straight to the clinic for high-risk patients with a track record of skin cancer. This is a new opportunity for skin cancer prevention.”

Prevalence of Skin Cancer Is Rising

Approximately 20% of people living in the U.S. will have skin cancer by age 70.9 Experts estimate nearly 9,500 people receive a diagnosis of skin cancer every day in the U.S.10 There are four main types of skin cancer, including basal cell carcinoma, squamous cell carcinoma, Merkel cell carcinoma and melanoma.

Of the nonmelanoma types of skin cancer, nearly 80% are basal cell, which develop more often on the head and neck. These types of cancer grow slowly and rarely spread. Nearly 20% are squamous cell carcinomas that can be found in areas of the skin that had been burned, exposed to X-rays or damaged by chemicals. Merkel cell is a rare and highly aggressive form of cancer.

Experts estimate over 100,000 adults in the U.S. are diagnosed with invasive melanoma each year and it is the fifth most common cancer that can develop in any age person.11 From 1982 until 2011, the rate of melanoma in the U.S. doubled.12 Since then, the number of people diagnosed has continued to rise.13

Long-Term Heart Benefits of Niacin

Nicotinic acid has been used for more than 40 years to help control dyslipidemia.14 Supplementation with nicotinic acid from 1,000 milligrams (mg) to 2,000 mg have been used daily to increase HDL and lower LDL cholesterol in carefully monitored studies. However, doses this high can produce side effects.

Some clinical trials have demonstrated patients on niacin therapy have a lower number of cardiovascular events and deaths. Other trials were not as positive. After a review of the literature, the U.S. Food and Drug Administration concluded:15

“… scientific evidence no longer supports the conclusion that a drug-induced reduction in triglyceride levels and/or increase in HDL-cholesterol levels in statin-treated patients results in a reduction in the risk of cardiovascular events.”

As I’ve written before, it is the relationship between HDL, LDL and triglycerides that is a greater predictor of heart health and not the absolute numbers of each. This means the FDA statement supports lowering LDL cholesterol with dangerous statin medications but suggests altering HDL and triglyceride levels with an inexpensive and safe supplement would have no effect on heart health.

In one study published in the Journal of the American College of Cardiology, researchers evaluated data from 1966 to 1975, looking at the effectiveness and safety of five drugs in a population of 8,341 men.16

Two medications were discontinued early in the study because of adverse events. The niacin treatment showed modest benefit in reducing the number of heart attacks, but did not reduce all-cause mortality. However, researchers followed up with the group 15 years later, nearly nine years after the participants stopped using the interventions.

They found all-cause mortality was similar to the placebo group in all drugs except niacin. Nine years after the participants stopped taking niacin, it continued to have a positive effect on their health, lowering all-cause mortality by 11% over the placebo group.

B Vitamins May Lower Risk of Worst COVID Outcomes

In the past, I have reviewed how nutrients such as vitamins C and D play a role in the treatment of COVID-19. A recently published paper has also highlighted the potential value of B vitamins.17 The paper was an international collaborative effort among researchers from the University of Oxford, United Arab Emirates University and the University of Melbourne Australia.18

Although there are no studies evaluating the efficacy of B vitamins on patients with COVID-19, the scientists advocate for research into the group of vitamins, stressing their importance to the immune system and immune competence. The paper does not suggest that B vitamins could prevent or treat COVID-19 alone.

However, as scientists have discovered many times, a single vitamin or nutritional supplement does not work alone, but in concert with others. COVID-19 has been dangerous for those with underlying medical conditions or older adults as it triggers an overactivation of your immune system and a cytokine or bradykinin storm.

Niacin and nicotinamide are important to your immune health as they are precursors to NAD+. This is a crucial signaling molecule that naturally declines with age. According to David Sinclair with Harvard Medical School, higher levels of NLRP3 inflammasomes are culprits in cytokines storms and are influenced by NAD+ levels.19

Niacin is a building block of NAD and NADP. This component is vital when combating inflammation, such as what happens during a viral infection like COVID-19. The scientists advocating for research into B vitamins explain:20

“NAD+ is released during the early stages of inflammation and has immunomodulatory properties, known to decrease the pro-inflammatory cytokines, IL-1β, IL-6 and TNF-α.

Recent evidence indicates that targeting IL-6 could help control the inflammatory storm in patients with COVID-19. Moreover, niacin reduces neutrophil infiltration and exhibits an anti-inflammatory effect in patients with ventilator-induced lung injury …

In addition, nicotinamide reduces viral replication (vaccinia virus, human immunodeficiency virus, enteroviruses, hepatitis B virus) and strengthens the body’s defense mechanisms. Taking into account the lung protective and immune strengthening roles of niacin, it could be used as an adjunct treatment for COVID-19 patients.”

Be Aware of a Niacin Flush

Niacin can be found in a wide variety of foods, including animal-based foods such as poultry, beef and fish, and nuts and grains.21 Many processed foods such as breads, cereals and infant formulas are fortified with niacin.

One of the highest sources of B3 is grass fed beef liver, and even a half a cup of chopped onions has 0.1 mg of niacin per serving. Other rich sources include brown rice, beef, pork and sockeye salmon.

If you are considering using a niacin supplement, be aware that one of the common side effects is a niacin flush. This most often happens when the vitamin is taken in large doses and usually only when using nicotinic acid. Niacinamide does not commonly produce the flushing side effect, but also does not have the same effect on cholesterol levels.22

A niacin flush doesn’t happen when you eat foods high in niacin. The condition is marked by symptoms of a burning or tingling sensation in the chest, neck and face.23 Your skin can feel warm to the touch and take on a flushed, red appearance. For some, as little as a 50 mg supplement can trigger the reaction.

Although it is irritating, and sometimes alarming, it is nonetheless harmless. Some find using a time release supplement, taking it with meals or drinking plenty of fluid can reduce the flushing effect. Taking smaller doses spread throughout the day may also reduce the potential of a reaction.

The Effects of Biotin on Your Hair, Nails and Thyroid


Reproduced from original article:
https://articles.mercola.com/sites/articles/archive/2020/07/20/biotin-benefits.aspx

Analysis by Dr. Joseph Mercola    Fact Checked
July 20, 2020

biotin benefits

STORY AT-A-GLANCE

  • Dermatologists frequently prescribe biotin for people with hair loss, despite a paucity of research proving it helps
  • Biotin insufficiency is more rare than other nutritional deficiencies but it does happen, leading to hair loss, depression, loss of appetite and numbness and tingling
  • Biotin is important in metabolism, having demonstrated the ability to improve glycemic control and strengthen nails
  • Supplementation can alter blood tests, including for thyroid, vitamin D and troponin, a marker of cardiac health

Your body uses vitamins for normal cell functioning; Essential vitamins must be consumed because they cannot be manufactured by the cells. Vitamins are grouped into two categories: fat soluble and water soluble.1 The fat soluble types get stored in fatty tissue and absorbed when eaten with dietary fat.

Water soluble vitamins are not stored by your body. Instead, excessive amounts are excreted through the urine. This means that essential water-soluble vitamins must be consumed on a regular basis to prevent any shortages. Vitamin B7, colloquially called biotin, is a water-soluble vitamin your body uses for energy metabolism.

Vitamins have different jobs within the body, including supporting your immune system, neurological system and energy metabolism. Biotin is a cofactor for an enzyme that is crucial in the metabolism of glucose, fatty acids and amino acids. It is also used in the production of hormones and cholesterol.2

Cholesterol is a fat-like substance that’s required in the right amounts for good health. Your body uses about 1,000 mg of cholesterol every day to synthesize hormones and vitamin D and to make cell membranes and the myelin sheath, which surrounds nerve cells.3 Without adequate biotin, your body can’t make enough cholesterol.

What’s Behind Your Hair Loss?

Despite a lack of research to support the idea that biotin may help address hair loss or improve skin and nail health, dermatologists have been prescribing it for years.4 Studies published in 20165 and 20176 included results having to do with the use of biotin to help thinning hair.

Although it was helpful when prescribed to those with a biotin deficiency, it didn’t appear to be useful in others. In the study published in 2016, researchers assessed patients from the Center for Dermatology and Hair Diseases who arrived with complaints of hair loss. They found that 38% of the women also had a biotin deficiency.

The most common type of hair loss in women and men is androgenetic alopecia.7 Men lose it at the front and vertex of the head, with thinning along the sides over the ear. Women start with diffuse thinning at the vertex.

By age 50, 50% of men will experience what is commonly called male pattern baldness. Interestingly, malnutrition, iron deficiency anemia and thyroid disease are also linked to hair loss. Other reasons for loss can include telogen effluvium, when the hair is lost in moderate amounts after a major body stress. Side effects from some drugs, medical illness and a fungal infection of the scalp can also cause hair loss.8

Yet, dermatologist Dr. Wilma Bergfeld from Cleveland Health Clinic finds that one of the most common causes is poor nutrition, more specifically the lack of essential vitamins. She says dermatologists start their detective work with a thorough physical exam and medical history, including family records and information on each patient’s diet, exercise and medications. She commented:9

“If your hair is falling out at the roots, often something is going wrong in your body or in your life situation. We find biotin to be very helpful for hair disorders. It also makes nails thicker, and oral biotin is exceedingly safe, even in large doses. Biotin improves hair growth and helps with inflammation. The hair follicle, the skin and the nails all benefit.”

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Common Signs of Insufficiency

Insufficiency of this B vitamin is more rare than other nutritional deficiencies, but it can still occur. Since the body does not store it, your nutrient intake must be consistent. Some of the common signs of insufficiency include hair loss, brittle nails and a red, scaly rash around the eyes, nose, mouth and genitals. Other symptoms may include:10

  • Depression
  • Loss of appetite or nausea
  • Tingling in the extremities
  • Numbness
  • Hallucinations

Several of the symptoms of biotin insufficiency are neurological in nature. Researchers also suggest that biotin supplementation may be helpful in the treatment of multiple sclerosis (MS). It’s crucial in the development of the myelin sheath, which gets damaged or destroyed in MS. In one study, scientists concluded, “These preliminary data suggest that high doses of biotin might have an impact on disability and progression in progressive MS.”11

Dr. Bruce Cree is a neurologist from the University of California San Francisco. He has a special interest in the disease and commented on a study of a pharmaceutical grade biotin treatment for MS:12

“Taken together, these studies are very promising and provide hope for a condition that has thus far been largely intractable using treatments targeting neuro-inflammation. That the extension study from the SPI trial showed an apparent durability of effect suggests that high dose biotin may have disease modifying properties in addition to its proposed role in enhancing energy metabolism.

Furthermore, the positive impact of high dose biotin points to a new line of inquiry in understanding the pathophysiology of progressive MS.”

Deficiency can happen with prolonged parenteral feedings that are not supplemented with vitamin B7. Individuals who eat raw egg whites for long periods of time can also experience deficiency, since the egg whites contain a type of protein called avidin, which binds with biotin,13 thus preventing the body from absorbing the nutrient.14

Biotin Brings the Good Stuff

Biotin plays a role in metabolic function and the metabolism of carbohydrates and amino acids. The breakdown of these nutrients helps create energy. In one study of 447 people with poorly controlled Type 2 diabetes, researchers added chromium picolinate with biotin for 90 days.15

When compared to the control group who received a placebo, the intervention group showed a reduction in their hemoglobin A1c by 0.54%. Fasting glucose levels were also lower, suggesting the combination may be a successful adjuvant to medication prescribed for glycemic control.

In a second, more recent study, researchers found that the synergistic effect with chromium picolinate is well-tolerated.16 Biotin has also been tested in people with Type 1 diabetes. Scientists believe it may have the potential to slow hepatic steatosis and control diabetic neuropathy and nephropathy.17

As you might expect, since a biotin deficiency can lead to brittle nails, adding extra biotin to the diet may help strengthen them. In an animal study, researchers looked at in vitro lab results involving animal claws and hooves. They used biotin as treatment for nail disorders and found “Several observations in animals and cells lines led to the hypothesis that biotin could be used to treat human nails.”18

Although supplementation with biotin rapidly clears skin rashes associated with the vitamin deficiency, there is no scientific evidence that it can improve everyone’s skin health.19 There is evidence that both deficiency and overload can adversely affect a growing baby. Women who are pregnant should consult their OB/GYN.

Supplements May Alter Thyroid Tests

The Food and Nutrition Board has not established the upper limits for biotin supplementation.20 In 1998, scholars from the National Academy of Sciences gathered information from clinical observations and studies in which biotin deficiency was induced.21 Factors they identified that affect an individual’s body requirement include the ingestion of raw egg whites, genetic defects, anticonvulsants and pregnancy.

They found no adverse effects associated with a high intake of biotin in humans or animals. People taking up to 200 milligrams by mouth each day did not have any signs of toxicity. However, based on results from an animal study, they did find that taking doses of biotin during pregnancy can inhibit placental growth and increase the risk of miscarriage.

The doses used in the study were higher than those that are frequently recommended and they were not found to be useful in determining an upper intake level for humans. The Harvard TH Chan School of Public Health reports that an upper limit for biotin has still not been established as there aren’t negative effects noted with high intakes.22

However, even taking a low dose can interfere with diagnostic blood tests commonly used to measure hormones, such as your thyroid hormone. It can also alter results of vitamin D tests.23 This can be crucial in optimizing your vitamin D level before the fall flu season and the expected second wave of COVID-19.

Taking biotin before a thyroid test has resulted in false diagnoses of Graves’ disease and severe hypothyroidism. A single 10 mg dose taken 24 hours before a thyroid function test can taint the results. The FDA published a warning in 2017 that biotin could interfere with lab tests.24

They received a report of an individual who died following a troponin test, which had been done for markers of cardiac health. The individual had been taking high levels of biotin and the test revealed a false negative, resulting in no treatment following a heart attack.

Biotin can also interact with medications, and some medications can lower biotin levels. For instance, anticonvulsant treatments can significantly lower biotin, which may happen by increasing catabolism of biotin and inhibiting absorption.25

Start With Biotin-Rich Foods

The best way to get your biotin is through whole food, especially if you are concerned about a supplement altering your test results. However, if you steer clear of taking excessive amounts and stop taking supplements at least 24 hours before a blood test, biotin supplements can be safe. It’s important to let your physician know you are taking supplements if you must have an emergency blood test.

There are two forms of biotin found in food. The first is free biotin, found in plants. The second is protein-bound in protein-based animal foods. The free version is more readily absorbed, but your body can use both forms. Foods high in free biotin include:26,27

  • Almonds
  • Sunflower seeds
  • Spinach and broccoli
  • Carrots, onions and cauliflower
  • Sweet potatoes

Protein-bound biotin is found in:

  • Organic, free-range/pastured eggs yolks
  • Organ meats such as liver and kidneys
  • Dairy products such as milk, butter and cheese (ideally organic raw milk from grass fed cows)
  • Seafood (just make sure it’s low in mercury and other contaminants, and wild-caught, not farmed)

One of the best sources of biotin is pastured egg yolk. Cooking the egg white deactivates the avidin, which means eating cooked eggs will not lead to a biotin deficiency. If you choose to take a biotin supplement for hair loss, the Cleveland Clinic dermatologists recommend a mega-B combination:

  • 3 milligrams of biotin
  • 30 milligrams of zinc
  • 200 milligrams of vitamin C
  • <1 milligram of folic acid

Bergfeld notes, “Occasionally, the mega B-vitamin combination gives some patients minor gastric trouble but switching them to biotin alone relieves it.”28